@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu17420: (2016-06-28 )
MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAKHGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPGTGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILFIDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSRFPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGRFVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA
Atome Classification :
(20 SA)
.........10........20........30........40........50..-...-...60........70........80........90........100.......110.......120.......130.......140.......150--..---.---.---....160.......------170..---......180.....-----..--190-......---...200..--.....210....--.--..220.......-..230.......240...----------------------....250.......----260.......270.-......280......--.290..---------.....300-..---......310.......320----------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ML
E
R
A
V
T
YKNN
G
Q
I
N
I
I
LNGQ
K
Q
VLTNA
E
A
E
A
E
Y
Q
A
A
L
Q
KNEAK
H
G
I
L
K
E
I
E
K
-
E
M
S
-
A
L
V
G
M
E
E
M
K
R
N
I
K
E
I
Y
A
W
I
F
V
N
Q
K
R
A
E
Q
G
L
K
V
G
K
Q
A
L
H
M
MFKGNPGT
G
K
T
T
V
A
R
L
I
G
K
L
F
F
E
M
N
VLSKG
H
L
I
E
A
E
R
A
D
L
V
G
E
Y
IG
H
T
A
Q
K
T
R
D
L
I
---
K
K
---S---L---G
G
I
L
F
IDE
A
Y
S
L
AR------G-GEK---DF
G
K
E
A
I
D
T
L
V
K
H
M
-----ED--K---QH
E
F
I
L
---
I
LAGYSRE--
M
D
H
F
LSLNPGLQ--S--RF
P
--
I
S
I
DFPD-
Y
S
V
T
Q
L
M
E
I
A
K
R
M
I
D
E
R
E
----------------------
Y
Q
LSQEA
E
W
K
L
K
D
Y
----
L
M
T
VKSTTSPIKFS-N
G
R
F
V
R
N
V
I
E
K
S
I
R
A
--
Q
A
M
R
L
L
---------MG
D
Q
Y
L
K
--
S
D
---
L
M
T
IKSQD
L
S
I
KEEASGSA----------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
96.80
41%
-144
- C3 -
3ZUH
2
CBBX_RHOSH
A:
[2-260]
-------------------------
T
S
I
D
L
R
A
E
Y
E
G
S
G
A
K
E
-----
V
L
E
E
L
D
R
-
E
----
L
I
G
L
K
P
V
K
D
R
I
R
E
T
A
A
L
L
L
V
E
R
A
R
Q
K
L
G
L
---
T
P
T
L
H
M
S
F
T
G
N
P
G
T
G
K
T
T
V
A
L
K
M
A
G
L
L
H
R
L
G
Y
V
R
K
G
H
L
V
S
V
T
R
D
D
L
V
G
Q
Y
I
G
H
T
A
P
K
T
K
E
V
L
---
K
R
---
A
---
M
---
G
G
V
L
F
I
D
E
A
Y
Y
L
Y
R
------
P
D
N
E
R
---
D
Y
G
Q
E
A
I
E
I
L
L
Q
V
M
-----
E
N
--
N
---
R
D
D
L
V
V
---
I
L
A
G
Y
A
D
R
--
M
E
N
F
F
Q
S
N
P
G
F
R
--
S
--
R
I
A
--
H
H
I
E
F
P
D
-
Y
S
D
E
E
L
F
E
I
A
G
H
M
L
D
D
Q
N
----------------------
Y
Q
M
T
P
E
A
E
T
A
L
R
A
Y
----
I
G
L
R
R
N
Q
P
---
H
F
A
-
N
A
R
S
I
R
N
A
L
D
R
A
R
L
R
--
Q
A
N
R
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
96.43
41%
-144
- C3 -
3ZUH
2
CBBX_RHOSH
D:
[2-260]
-------------------------
T
S
I
D
L
R
A
E
Y
E
G
S
G
A
K
E
-----
V
L
E
E
L
D
R
-
E
----
L
I
G
L
K
P
V
K
D
R
I
R
E
T
A
A
L
L
L
V
E
R
A
R
Q
K
L
G
L
---
T
P
T
L
H
M
S
F
T
G
N
P
G
T
G
K
T
T
V
A
L
K
M
A
G
L
L
H
R
L
G
Y
V
R
K
G
H
L
V
S
V
T
R
D
D
L
V
G
Q
Y
I
G
H
T
A
P
K
T
K
E
V
L
---
K
R
---
A
---
M
---
G
G
V
L
F
I
D
E
A
Y
Y
L
Y
R
------
P
D
N
E
R
---
D
Y
G
Q
E
A
I
E
I
L
L
Q
V
M
-----
E
N
--
N
---
R
D
D
L
V
V
---
I
L
A
G
Y
A
D
R
--
M
E
N
F
F
Q
S
N
P
G
F
R
--
S
--
R
I
A
--
H
H
I
E
F
P
D
-
Y
S
D
E
E
L
F
E
I
A
G
H
M
L
D
D
Q
N
----------------------
Y
Q
M
T
P
E
A
E
T
A
L
R
A
Y
----
I
G
L
R
R
N
Q
P
---
H
F
A
-
N
A
R
S
I
R
N
A
L
D
R
A
R
L
R
--
Q
A
N
R
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
96.31
41%
-142
- C3 -
3SYL
3
CBBX_RHOSH
B:
[9-267]
-------------------------
T
S
I
D
L
R
A
E
Y
E
G
S
G
A
K
E
-----
V
L
E
E
L
D
R
-
E
----
L
I
G
L
K
P
V
K
D
R
I
R
E
T
A
A
L
L
L
V
E
R
A
R
Q
K
L
G
L
---
T
P
T
L
H
M
S
F
T
G
N
P
G
T
G
K
T
T
V
A
L
K
M
A
G
L
L
H
R
L
G
Y
V
R
K
G
H
L
V
S
V
T
R
D
D
L
V
G
Q
Y
I
G
H
T
A
P
K
T
K
E
V
L
---
K
R
---
A
---
M
---
G
G
V
L
F
I
D
E
A
Y
Y
L
Y
R
P-----
D
-
N
E
R
---
D
Y
G
Q
E
A
I
E
I
L
L
Q
V
M
-----
E
N
--
N
---
R
D
D
L
V
V
---
I
L
A
G
Y
A
D
R
--
M
E
N
F
F
Q
S
N
P
G
F
R
--
S
--
R
I
A
--
H
H
I
E
F
P
D
-
Y
S
D
E
E
L
F
E
I
A
G
H
M
L
D
D
Q
N
----------------------
Y
Q
M
T
P
E
A
E
T
A
L
R
A
Y
----
I
G
L
R
R
N
Q
P
---
H
F
A
-
N
A
R
S
I
R
N
A
L
D
R
A
R
L
R
--
Q
A
N
R
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
96.30
41%
-144
- C3 -
3ZUH
2
CBBX_RHOSH
E:
[2-260]
-------------------------
T
S
I
D
L
R
A
E
Y
E
G
S
G
A
K
E
-----
V
L
E
E
L
D
R
-
E
----
L
I
G
L
K
P
V
K
D
R
I
R
E
T
A
A
L
L
L
V
E
R
A
R
Q
K
L
G
L
---
T
P
T
L
H
M
S
F
T
G
N
P
G
T
G
K
T
T
V
A
L
K
M
A
G
L
L
H
R
L
G
Y
V
R
K
G
H
L
V
S
V
T
R
D
D
L
V
G
Q
Y
I
G
H
T
A
P
K
T
K
E
V
L
---
K
R
---
A
---
M
---
G
G
V
L
F
I
D
E
A
Y
Y
L
Y
R
------
P
D
N
E
R
---
D
Y
G
Q
E
A
I
E
I
L
L
Q
V
M
-----
E
N
--
N
---
R
D
D
L
V
V
---
I
L
A
G
Y
A
D
R
--
M
E
N
F
F
Q
S
N
P
G
F
R
--
S
--
R
I
A
--
H
H
I
E
F
P
D
-
Y
S
D
E
E
L
F
E
I
A
G
H
M
L
D
D
Q
N
----------------------
Y
Q
M
T
P
E
A
E
T
A
L
R
A
Y
----
I
G
L
R
R
N
Q
P
---
H
F
A
-
N
A
R
S
I
R
N
A
L
D
R
A
R
L
R
--
Q
A
N
R
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.16
41%
0
- C- -
3SYL
3
CBBX_RHOSH
A:
[9-270]
-------------------------
T
S
I
D
L
R
A
E
Y
E
G
S
G
A
K
E
-----
V
L
E
E
L
D
R
-
E
----
L
I
G
L
K
P
V
K
D
R
I
R
E
T
A
A
L
L
L
V
E
R
A
R
Q
K
L
G
L
A
H
E
T
P
T
L
H
M
S
F
T
G
N
P
G
T
G
K
T
T
V
A
L
K
M
A
G
L
L
H
R
L
G
Y
V
R
K
G
H
L
V
S
V
T
R
D
D
L
V
G
Q
Y
I
G
H
T
A
P
K
T
K
E
V
L
---
K
R
---
A
---
M
---
G
G
V
L
F
I
D
E
A
Y
Y
L
Y
R
P-----
D
-------
D
Y
G
Q
E
A
I
E
I
L
L
Q
V
M
-----
E
N
--
N
---
R
D
D
L
V
V
---
I
L
A
G
Y
A
D
R
--
M
E
N
F
F
Q
S
N
P
G
F
R
--
S
--
R
I
A
--
H
H
I
E
F
P
D
-
Y
S
D
E
E
L
F
E
I
A
G
H
M
L
D
D
Q
N
----------------------
Y
Q
M
T
P
E
A
E
T
A
L
R
A
Y
----
I
G
L
R
R
N
Q
P
---
H
F
A
-
N
A
R
S
I
R
N
A
L
D
R
A
R
L
R
--
Q
A
N
R
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
95.93
41%
-144
- C3 -
3ZUH
2
CBBX_RHOSH
B:
[2-260]
-------------------------
T
S
I
D
L
R
A
E
Y
E
G
S
G
A
K
E
-----
V
L
E
E
L
D
R
-
E
----
L
I
G
L
K
P
V
K
D
R
I
R
E
T
A
A
L
L
L
V
E
R
A
R
Q
K
L
G
L
---
T
P
T
L
H
M
S
F
T
G
N
P
G
T
G
K
T
T
V
A
L
K
M
A
G
L
L
H
R
L
G
Y
V
R
K
G
H
L
V
S
V
T
R
D
D
L
V
G
Q
Y
I
G
H
T
A
P
K
T
K
E
V
L
---
K
R
---
A
---
M
---
G
G
V
L
F
I
D
E
A
Y
Y
L
Y
R
------
P
D
N
E
R
---
D
Y
G
Q
E
A
I
E
I
L
L
Q
V
M
-----
E
N
--
N
---
R
D
D
L
V
V
---
I
L
A
G
Y
A
D
R
--
M
E
N
F
F
Q
S
N
P
G
F
R
--
S
--
R
I
A
--
H
H
I
E
F
P
D
-
Y
S
D
E
E
L
F
E
I
A
G
H
M
L
D
D
Q
N
----------------------
Y
Q
M
T
P
E
A
E
T
A
L
R
A
Y
----
I
G
L
R
R
N
Q
P
---
H
F
A
-
N
A
R
S
I
R
N
A
L
D
R
A
R
L
R
--
Q
A
N
R
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
95.92
41%
-144
- C3 -
3ZUH
2
CBBX_RHOSH
F:
[2-260]
-------------------------
T
S
I
D
L
R
A
E
Y
E
G
S
G
A
K
E
-----
V
L
E
E
L
D
R
-
E
----
L
I
G
L
K
P
V
K
D
R
I
R
E
T
A
A
L
L
L
V
E
R
A
R
Q
K
L
G
L
---
T
P
T
L
H
M
S
F
T
G
N
P
G
T
G
K
T
T
V
A
L
K
M
A
G
L
L
H
R
L
G
Y
V
R
K
G
H
L
V
S
V
T
R
D
D
L
V
G
Q
Y
I
G
H
T
A
P
K
T
K
E
V
L
---
K
R
---
A
---
M
---
G
G
V
L
F
I
D
E
A
Y
Y
L
Y
R
------
P
D
N
E
R
---
D
Y
G
Q
E
A
I
E
I
L
L
Q
V
M
-----
E
N
--
N
---
R
D
D
L
V
V
---
I
L
A
G
Y
A
D
R
--
M
E
N
F
F
Q
S
N
P
G
F
R
--
S
--
R
I
A
--
H
H
I
E
F
P
D
-
Y
S
D
E
E
L
F
E
I
A
G
H
M
L
D
D
Q
N
----------------------
Y
Q
M
T
P
E
A
E
T
A
L
R
A
Y
----
I
G
L
R
R
N
Q
P
---
H
F
A
-
N
A
R
S
I
R
N
A
L
D
R
A
R
L
R
--
Q
A
N
R
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
95.91
41%
-144
- C3 -
3ZUH
2
CBBX_RHOSH
C:
[2-260]
-------------------------
T
S
I
D
L
R
A
E
Y
E
G
S
G
A
K
E
-----
V
L
E
E
L
D
R
-
E
----
L
I
G
L
K
P
V
K
D
R
I
R
E
T
A
A
L
L
L
V
E
R
A
R
Q
K
L
G
L
---
T
P
T
L
H
M
S
F
T
G
N
P
G
T
G
K
T
T
V
A
L
K
M
A
G
L
L
H
R
L
G
Y
V
R
K
G
H
L
V
S
V
T
R
D
D
L
V
G
Q
Y
I
G
H
T
A
P
K
T
K
E
V
L
---
K
R
---
A
---
M
---
G
G
V
L
F
I
D
E
A
Y
Y
L
Y
R
------
P
D
N
E
R
---
D
Y
G
Q
E
A
I
E
I
L
L
Q
V
M
-----
E
N
--
N
---
R
D
D
L
V
V
---
I
L
A
G
Y
A
D
R
--
M
E
N
F
F
Q
S
N
P
G
F
R
--
S
--
R
I
A
--
H
H
I
E
F
P
D
-
Y
S
D
E
E
L
F
E
I
A
G
H
M
L
D
D
Q
N
----------------------
Y
Q
M
T
P
E
A
E
T
A
L
R
A
Y
----
I
G
L
R
R
N
Q
P
---
H
F
A
-
N
A
R
S
I
R
N
A
L
D
R
A
R
L
R
--
Q
A
N
R
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
95.25
39%
0
- C- -
3SYK
3
CBBX_RHOSH
A:
[9-272]
-------------------------
T
S
I
D
L
R
A
E
Y
E
G
S
G
A
K
E
-----
V
L
E
E
L
D
R
-
E
----
L
I
G
L
K
P
V
K
D
R
I
R
E
T
A
A
L
L
L
V
E
R
A
R
Q
K
L
G
L
A
H
E
T
P
T
L
H
M
S
F
T
G
N
P
G
T
G
K
T
T
V
A
L
K
M
A
G
L
L
H
R
L
G
Y
V
R
K
G
H
L
V
S
V
T
R
D
D
L
V
G
Q
Y
I
G
H
T
A
P
K
T
K
E
V
L
---
K
R
---
A
---
M
---
G
G
V
L
F
I
D
E
A
Y
Y
L
Y
R
P-----
D
-------
D
Y
G
Q
E
A
I
E
I
L
L
Q
V
M
-----
E
N
--
N
---
R
D
D
L
V
V
---
I
L
A
G
Y
A
D
R
--
M
E
N
F
F
Q
S
N
P
G
F
R
--
S
--
R
I
A
--
H
H
I
E
F
P
D
-
Y
S
D
E
E
L
F
E
I
A
G
H
M
L
D
D
Q
N
----------------------
Y
Q
M
T
P
E
A
E
T
A
L
R
A
Y
----
I
G
L
R
R
N
Q
P
---
H
F
A
-
N
A
R
S
I
R
N
A
L
D
R
A
R
L
R
--
Q
A
N
R
L
F
---------
T
A
-----------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
92.63
42%
-139
- C3 -
3SYL
3
CBBX_RHOSH
A:
[22-290]
-----------------------------------------------
A
K
E
V
L
E
-
E
L
D
R
E
L
I
G
L
K
P
V
K
D
R
I
R
E
T
A
A
L
L
L
V
E
R
A
R
Q
K
L
G
L
A
H
E
T
P
T
L
H
M
S
F
T
G
N
P
G
T
G
K
T
T
V
A
L
K
M
A
G
L
L
H
R
L
G
Y
V
R
K
G
H
L
V
S
V
T
R
D
D
L
V
G
Q
Y
I
G
H
T
A
P
K
T
K
E
V
L
---
K
R
---
A
---
M
---
G
G
V
L
F
I
D
E
A
Y
Y
L
Y
R
------
P
-
D
-----
D
Y
G
Q
E
A
I
E
I
L
L
Q
V
M
-----
E
N
--
N
---
R
D
D
L
V
V
---
I
L
A
G
Y
A
D
R
--
M
E
N
F
F
Q
S
N
P
G
F
R
--
S
--
R
I
A
--
H
H
I
E
F
P
D
-
Y
S
D
E
E
L
F
E
I
A
G
H
M
L
D
D
Q
N
----------------------
Y
Q
M
T
P
E
A
E
T
A
L
R
A
Y
----
I
G
L
R
R
---
N
Q
P
H
F
A
-
N
A
R
S
I
R
N
A
L
D
R
A
R
L
R
--
Q
A
N
R
L
F
---------
T
A
---
P
L
D
A
R
A
---
L
S
T
I
A
E
E
D
I
R
A
S
-----------------------------------------------------------------------------------------------------------------------
51
HHSearch
64.08
23%
-114
- C3 -
4WW0
1
FTSH_AQUAE
A:
[12-278]
-------------------------------------------------
K
P
K
V
-
T
F
K
-
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
L
K
D
P
V
K
F
Q
K
L
G
G
---
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
-------
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
---
E
T
---
A
K
K
H
A
---
P
C
M
I
F
I
D
E
I
D
A
V
G
R
---------------
E
R
E
Q
T
L
N
Q
L
L
V
E
M
-----
D
G
F
D
T
---
S
D
G
I
I
V
---
I
A
A
T
N
R
P
D
-------
I
L
D
P
A
L
L
--
R
PG
R
F
D
--
R
Q
I
F
I
P
K
-
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
----------------------
L
A
-
K
D
V
D
L
E
F
V
A
--------
R
A
-------
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
--
A
A
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
63.70
29%
-138
- C3 -
2CEA
-
FTSH_THEMA
A:
[20-238]
-------------------------------------------------------------
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
---
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
---
E
A
N
V
----
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
---
H
---
A
---
P
C
I
V
F
I
D
E
I
D
A
V
G
R
----------
H
---
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
-----
D
G
F-
D
---
S
K
E
G
I
I
---
V
M
A
A
T
N
R
P
DI
L
D
P
A
L
-
L
R
P
G
-------
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
62.85
29%
-132
- C3 -
2CE7
-
FTSH_THEMA
A:
[20-238]
-------------------------------------------------------------
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
---
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
---
E
A
N
V
----
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
---
H
---
A
---
P
C
I
V
F
I
D
E
I
D
A
V
G
R
----------
H
---
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
-----
D
G
F-
D
---
S
K
E
G
I
I
---
V
M
A
A
T
N
R
P
DI
L
D
P
A
L
-
L
R
P
G
-------
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
60.82
28%
-137
- C3 -
3KDS
-
FTSH_THEMA
E:
[20-212]
-------------------------------------------------------------
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
---
I
L
L
V
G
P
P
G
T
G
A
T
L
L
A
R
A
V
A
G
---
E
A
N
V
----
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
AQA
K
A
---
H
---
A
---
P
C
I
V
F
I
D
E
I
D
A
V
G
R
----------
H
---
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
-----
D
G
F-
D
---
S
K
E
G
I
I
---
V
M
A
A
T
N
R
P
DI
L
D
P
A
L
-
L
R
P
G
-------
R
F
D
KK
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Fugue
60.72
20%
-103
- C3 -
1HQC
2
RUVB_THET8
A:
[5-318]
------------------------------------------------
A
L
R
P
K
-
T
L
D
-
E
Y
I
G
Q
E
R
L
K
Q
K
L
R
V
Y
L
E
A
A
K
A
R
K
E
P
L
E
----------
H
L
L
L
F
G
P
P
G
L
G
K
T
T
L
A
H
V
I
A
H
E
L
G
V
N
L
R
V
T
S
G
P
A
I
E
-
K
P
G
D
L
A
A
I
L
A
N
S
L
E
E
----------------------
G
D
I
L
F
I
D
E
I
H
R
L
S
R
------
Q
-
A
E
E
---
H
L
Y
P
A
M
E
D
F
V
M
D
I
V
IGQGP
A
A
--
R
---
T
I
R
L
E
L
P
R
F
T
L
I
G
A
T
T
R
--
P
G
---
L
I
T
A
P
L
L
--
S
--
R
F
G
--
I
V
E
H
L
E
Y
-
Y
T
P
E
E
L
A
Q
G
V
M
R
D
A
R
L
L
G
----------------------
V
R
I
T
E
E
A
A
L
E
I
G
R
R
SRGT
M
R
V
A
K
R
L
F
R
R
V
R
D
F
-
A
Q
V
A
G
E
E
V
I
T
R
E
R
A
L
--
E
A
L
A
A
L
GLDELGLE
K
R
D
R
E
I
L
E
--
V
L
---
I
L
R
F
G
G
G
P
V
G
L
A
T
L
A
T
A
L
S
ED
P
G
T
L
E
E
VH
E
P
Y
L
I
R
Q
GL
L
K
R
T
PR
G
R
V
P
T
E
L
A
Y
R
H
L
GYPPPV---------------------------------------------------------------------
65
Fugue
59.39
21%
-77
- C3 -
2CE7
1
FTSH_THEMA
A:
[5-457]
--------------------------------------------
Y
K
P
S
G
N
K
R
V
-
T
F
K
-
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
---
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
-------
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
---
A
Q
---
A
---
K
A
H
A
P
C
I
V
F
I
D
E
---
I
D
A
------
V
-
G
R
H
---
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
-----
D
G
F-
D
---
S
K
E
G
I
I
---
V
M
A
A
T
N
R
P
--
D
I
----
L
D
P
A
L
L
--
R
PG
R
F
D
--
K
K
I
V
V
D
P
-
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
EDVN
L
E
I
I
A
K
R
T
PGFV
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
----
G
R
D
K
I
T
M
K
D
F
E
E
A
I
-
D
R
V
I
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
---------
V
S
T
V
V
P
N
--
G
E
PVH
R
I
S
I
I
K
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
FGDVTSGA
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
CQLGMSEELGPLAWGKLRNYS
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
KETIE
G
D
E
L
R
R
I
L
S
17
PsiBlast_PDB
59.02
29%
-128
- C3 -
2DHR
1
FTSH_THET8
A:
[18-202]
-------------------------------------------
R
A
R
V
L
T
E
A
P
K
V
T
F
K
-
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
---
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
---
E
A
R
V
----
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
---
H
---
A
---
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
GSGV
G
-
G
G
N
---
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
-----
D
G
F-
E
---
K
D
T
A
I
V
---
V
M
A
A
T
N
R
P
DI
L
D
P
A
L
-
L
R
P
G
R
F
--
D
--
R
-
Q
--
I
A
I
D
A
P
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
58.64
16%
-116
- C3 -
1XWI
2
VPS4B_HUMAN
A:
[6-236]
-------------------------------------------------
R
P
N
V
-
K
W
S
-
D
V
A
G
L
E
G
A
K
E
A
L
K
E
A
V
I
L
P
I
K
F
P
H
L
F
T
G
K
---
R
T
P
W
R
G
I
L
L
F
G
P
P
G
T
G
K
S
Y
L
A
K
A
V
A
T
E
A
N
N
------
S
T
F
F
S
I
S
S
S
D
L
V
S
K
W
L
G
E
S
E
K
L
V
K
N
L
F
---
Q
L
A
R
E
N
---
K
---
P
S
I
I
F
I
D
E
I
D
S
L
C
G
------
S
-
R
S
E
NES
E
A
A
R
R
I
K
T
E
F
L
V
Q
M
-----
Q
G
--
V
GVD
N
D
G
I
L
V
---
L
G
A
T
N
I
P
W
-------
V
L
D
S
A
I
R
--
R
--
R
F
E
--
K
R
I
Y
I
P
L
-
P
E
P
H
A
R
A
A
M
F
K
L
H
L
G
T
T
Q
----------------------
N
S
L
T
E
A
D
F
R
E
L
G
R
K
--------------
T
D
G
Y
-
S
G
A
D
I
S
I
I
V
R
D
A
L
M
Q
--
P
V
R
K
V
Q
---------
S
------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
58.51
29%
-115
- C3 -
4EIW
1
FTSH_THET8
A:
[27-211]
-------------------------------------------
R
A
R
V
L
T
E
A
P
K
V
T
F
K
-
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
---
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
---
E
A
R
V
----
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
---
H
---
A
---
P
C
I
V
F
I
D
E
I
D
A
V
G
R
KRGSGV
G
-
G
G
N
---
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
-----
D
G
F-
E
---
K
D
T
A
I
V
---
V
M
A
A
T
N
R
P
DI
L
D
P
A
L
-
L
R
P
G
R
F
--
D
--
R
-
Q
--
I
A
I
D
A
P
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
58.39
22%
-110
- C3 -
1IXZ
5
FTSH_THET8
A:
[14-253]
------------------------------------------------------
T
F
K
-
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
L
K
N
P
S
R
F
H
E
M
G
A
---
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
-------
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
---
E
T
A
K
R
H
---
A
---
P
C
I
V
F
I
D
E
I
D
A
V
G
R
-----------N--
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
-----
D
G
--
F
EK-
D
T
A
I
V
V
---
M
A
A
T
N
R
P
D
-------
I
L
D
P
A
L
L
RP
G
--
R
F
D
--
R
Q
I
A
I
D
A
-
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
----------------------
L
-
A
E
D
V
D
L
A
L
L
A
--------
K
R
------
T
P
G
F
-
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
--
A
A
R
E
G
R
---------
R
---------------
K
I
T
M
K
D
L
E
E
A
A
----------------------------------------------------------------------------------------------------------------------