@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu17440: (2016-06-28 )
MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSYRKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFGVLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVAAAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEELEPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYSLQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREKMIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYVAYVQGGLTYSHVKNAICSAVDSLMQKQLI
Atome Classification :
(20 SA)
.........10........20........30........40...------.....50........60.....---.---..70--.........----80----..-......90.-.---......100.......110---.....-..120........130.......140.......150----------.----------........160.--.-.--....170.......180.......190.......200.......210.....---..220----.-----........230.....-..240.......-250......-..260.--......270.......280-.--------.--...-..290.......300....---...310.......320.......330-.......------340.......350.......360.......370.......380.......390.......400.......410.......420
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MFDTL
T
H
G
E
L
L
K
K
T
A
M
E
V
E
A
D
I
A
G
I
H
K
Q
I
E
E
I
S
E
R
N
E
W
R
V
L
Q
S
Y
------
R
KHKVSDTHFTPSTGYGY
D
D
I
G
---
R
---
D
T
L
---
E
S
I
Y
A
D
V
FG----GE----AG-LVR
P
Q
IISG-T---
H
A
I
S
I
A
L
F
G
VLRPGD
E
L
L
Y
---
I
TGK
P
-
Y
D
T
-
L
E
E
I
V
GVRGGENAGSL
K
D
F
Q
I
GY
N
A
V
DLTK------------D----------GKI
D
Y
D
A
V
AAAI--N-P--K
T
K
V
I
G
I
QRSKGYANR
P
S
F
L
I
S
E
I
K
E
M
I
R
F
V
K
E
INE
N
L
I
V
F
V
D
N
C
Y
G
E
F
V
E
E---L
E
P
------
C
-----HV
G
A
D
L
M
A
G
S
L
IKNPG-GGLAKTG
G
Y
L
V
G-
K
-
A
K
W
I
E
A
C
-SYRMTS--PGI
G
R
E
AG
A
S
L
Y
S
L
Q
E
M
Y
Q
-
G
--------
F
--FL
A
-
P
H
V
V
S
Q
S
LK
G
A
V
F
T
A
R
F
L
E
---
K
LGFTSNPKWD
A
K
R
T
D
L
I
Q
SVEFS
D
R
-
E
K
M
I
A
F
C
------
Q
A
I
Q
FASPINAHVTPYPAYMPGYED
D
V
I
M
AAG
T
F
I
QG
A
S
I
E
L
SADGPIRP
P
Y
V
A
Y
VQGG
L
T
Y
S
H
V
K
N
A
I
C
S
A
V
D
S
L
M
Q
K
QLI
1
PsiBlast_PDB
91.50
73%
-99
- C1 -
3HT4
-
?
A:
[2-416]
-
F
D
R
L
K
N
G
E
K
I
A
P
I
V
K
E
V
E
S
Q
I
T
E
V
H
K
R
A
D
E
V
I
E
S
N
Q
F
R
V
L
E
S
F
------
G
K
H
K
I
S
D
S
H
F
I
P
T
T
G
Y
G
Y
D
D
I
G
---
R
---
D
T
L
---
E
K
V
Y
A
D
V
F
G
----
A
E
----
A
G
-
L
V
R
P
Q
I
I
S
G
-
T
---
H
A
I
S
T
A
L
F
G
I
L
R
P
G
D
E
L
L
Y
---
I
T
G
K
P
-
Y
D
T
-
L
E
E
I
V
G
V
R
G
-
K
G
V
G
S
F
K
E
Y
N
I
G
Y
N
A
V
P
L
T
E
------------
G
----------
G
L
V
D
F
E
A
V
A
A
A
I
--
H
-
S
--
N
T
K
M
I
G
I
Q
R
S
K
G
Y
A
T
R
P
S
F
T
I
S
Q
I
K
E
M
I
A
F
V
K
E
I
K
P
D
V
V
V
F
V
D
N
C
Y
G
E
F
I
E
E
---
Q
E
P
------
C
-----
H
V
G
A
D
L
M
A
G
S
L
I
K
N
P
G
-
G
G
I
V
K
T
G
G
Y
I
V
G
-
K
-
E
Q
Y
V
E
A
C
-
A
Y
R
L
T
S
--
P
G
I
G
A
E
A
G
A
S
L
Y
S
L
Q
E
M
Y
Q
-
G
--------
F
--
F
L
A
-
P
H
V
A
G
Q
A
L
K
G
A
I
F
T
A
A
F
L
E
---
K
L
G
M
N
T
S
P
A
W
N
A
P
R
T
D
L
I
Q
S
V
Q
F
D
D
K
-
D
R
M
I
A
F
C
------
Q
A
I
Q
Y
A
S
P
I
N
S
H
F
T
P
Y
A
N
Y
M
P
G
Y
E
D
D
V
I
M
A
A
G
T
F
I
Q
G
A
S
I
E
L
S
A
D
G
P
I
R
P
P
Y
V
A
Y
V
Q
G
G
L
T
Y
S
H
V
K
I
A
I
C
S
A
I
D
E
L
I
E
----
46
HHSearch
89.31
67%
-91
- C1 -
3JZL
3
?
A:
[5-408]
----------
I
Q
A
I
R
K
K
V
E
T
Q
I
D
D
L
Q
N
K
T
D
E
I
A
E
F
N
Q
A
K
V
L
D
A
F
------
Q
E
N
K
V
S
D
F
H
F
H
P
S
T
G
Y
G
Y
D
D
E
G
---
R
---
D
T
L
---
E
R
V
Y
A
T
V
F
K
----
T
E
----
A
A
-
L
V
R
P
Q
I
I
S
G
-
T
---
H
A
I
S
T
V
L
F
G
I
L
R
P
D
D
E
L
L
Y
---
I
T
G
Q
P
-
Y
D
T
-
L
E
E
I
V
G
I
R
K
Q
-
G
Q
G
S
L
K
D
F
H
I
G
Y
S
S
V
P
L
L
E
------------
N
----------
G
D
V
D
F
P
R
I
A
K
K
M
--
T
-
P
--
K
T
K
M
I
G
I
Q
R
S
R
G
Y
A
D
R
P
S
F
T
I
E
K
I
K
E
M
I
V
F
V
K
N
I
N
P
E
V
I
V
F
V
D
N
C
Y
G
E
F
V
E
Y
---
Q
E
P
------
P
-----
E
V
G
A
D
I
I
A
G
S
L
I
K
N
P
G
-
G
G
L
A
K
T
G
G
Y
I
A
G
-
K
-
E
A
L
V
D
L
C
-
G
Y
R
L
T
T
--
P
G
I
G
R
E
A
G
A
S
L
Y
S
L
L
E
M
Y
Q
-
G
--------
F
--
F
L
A
-
P
H
V
T
A
Q
A
I
K
G
A
R
F
T
A
A
M
L
A
---
E
F
G
V
E
A
D
P
V
W
D
A
P
R
T
D
L
I
Q
S
V
S
F
H
N
K
-
E
K
M
V
A
F
A
------
Q
A
I
Q
A
A
S
P
V
N
A
H
V
L
P
I
G
A
Y
M
P
G
Y
E
D
D
V
I
M
A
A
G
T
F
I
Q
G
A
S
L
E
L
T
A
D
G
P
I
R
E
P
Y
Q
L
Y
V
Q
G
G
L
T
Y
E
H
I
K
I
A
V
T
R
A
I
Q
K
I
------
2
PsiBlast_PDB
87.98
67%
-89
- C1 -
3FD0
24
?
A:
[11-409]
----------------
K
V
E
Q
Q
I
T
S
L
Q
N
E
T
D
E
I
A
E
F
N
Q
A
K
V
L
D
A
F
------
Q
E
N
K
V
S
D
F
H
F
N
P
S
T
G
Y
G
Y
D
D
E
G
---
R
---
D
T
L
---
E
R
V
Y
A
S
V
F
K
----
T
E
----
A
A
-
L
V
R
P
Q
I
I
S
G
-
T
---
H
A
I
S
T
V
L
F
G
I
L
R
P
G
D
E
L
L
Y
---
I
T
G
E
P
-
Y
D
T
-
L
E
E
I
V
G
I
R
S
-
E
G
Q
G
S
L
K
D
F
Q
I
G
Y
D
A
V
P
L
L
P
------------
N
----------
G
E
I
D
Y
P
A
V
S
K
K
I
--
S
-
A
--
N
T
K
M
I
G
I
Q
R
S
R
G
Y
A
D
R
P
S
F
T
I
E
K
I
K
E
M
V
T
F
V
K
N
I
N
P
N
I
I
V
F
V
D
N
C
Y
G
E
F
V
E
R
---
I
E
P
------
T
-----
E
V
G
A
D
I
I
A
G
S
L
I
K
N
P
G
-
G
G
L
A
K
T
G
G
Y
I
A
G
-
R
-
N
T
L
V
D
L
C
-
G
Y
R
L
T
T
--
P
G
I
G
R
E
A
G
A
S
L
Y
S
L
L
E
M
Y
Q
-
G
--------
F
--
F
L
A
-
P
H
V
T
A
Q
A
I
K
G
A
R
F
T
A
A
M
L
A
---
E
F
G
V
E
A
D
P
L
W
D
A
K
R
T
D
L
I
Q
S
V
S
F
H
S
K
-
D
K
M
I
A
F
A
------
Q
A
I
Q
A
A
S
P
V
N
A
H
V
L
P
I
G
A
Y
M
P
G
Y
E
D
D
V
I
M
A
A
G
T
F
I
Q
G
A
S
L
E
L
T
A
D
G
P
I
R
E
P
Y
Q
L
Y
V
Q
G
G
L
T
Y
E
H
V
K
I
A
V
T
R
A
I
E
N
S
L
-----
3
PsiBlast_PDB
87.95
65%
-91
- C1 -
3JZL
3
?
A:
[11-409]
----------------
K
V
E
T
Q
I
D
D
L
Q
N
K
T
D
E
I
A
E
F
N
Q
A
K
V
L
D
A
F
------
Q
E
N
K
V
S
D
F
H
F
H
P
S
T
G
Y
G
Y
D
D
E
G
---
R
---
D
T
L
---
E
R
V
Y
A
T
V
F
K
----
T
E
----
A
A
-
L
V
R
P
Q
I
I
S
G
-
T
---
H
A
I
S
T
V
L
F
G
I
L
R
P
D
D
E
L
L
Y
---
I
T
G
Q
P
-
Y
D
T
-
L
E
E
I
V
G
I
R
K
-
Q
G
Q
G
S
L
K
D
F
H
I
G
Y
S
S
V
P
L
L
E
------------
N
----------
G
D
V
D
F
P
R
I
A
K
K
M
--
T
-
P
--
K
T
K
M
I
G
I
Q
R
S
R
G
Y
A
D
R
P
S
F
T
I
E
K
I
K
E
M
I
V
F
V
K
N
I
N
P
E
V
I
V
F
V
D
N
C
Y
G
E
F
V
E
Y
---
Q
E
P
------
P
-----
E
V
G
A
D
I
I
A
G
S
L
I
K
N
P
G
-
G
G
L
A
K
T
G
G
Y
I
A
G
-
K
-
E
A
L
V
D
L
C
-
G
Y
R
L
T
T
--
P
G
I
G
R
E
A
G
A
S
L
Y
S
L
L
E
M
Y
Q
-
G
--------
F
--
F
L
A
-
P
H
V
T
A
Q
A
I
K
G
A
R
F
T
A
A
M
L
A
---
E
F
G
V
E
A
D
P
V
W
D
A
P
R
T
D
L
I
Q
S
V
S
F
H
N
K
-
E
K
M
V
A
F
A
------
Q
A
I
Q
A
A
S
P
V
N
A
H
V
L
P
I
G
A
Y
M
P
G
Y
E
D
D
V
I
M
A
A
G
T
F
I
Q
G
A
S
L
E
L
T
A
D
G
P
I
R
E
P
Y
Q
L
Y
V
Q
G
G
L
T
Y
E
H
I
K
I
A
V
T
R
A
I
Q
K
I
V
-----
45
HHSearch
84.77
49%
-103
- C1 -
3HVY
7
?
A:
[17-426]
-------
N
E
R
V
L
E
L
Y
E
R
A
L
N
D
V
E
K
E
F
K
Y
Y
D
E
I
R
E
Y
N
Q
L
K
V
L
K
A
F
------
Q
E
E
R
I
S
E
S
H
F
T
N
S
S
G
Y
G
Y
N
D
I
G
---
R
---
D
S
L
---
D
R
V
Y
A
N
I
F
N
----
T
E
----
S
A
-
F
V
R
P
H
F
V
N
G
-
T
---
H
A
I
G
A
A
L
F
G
N
L
R
P
N
D
T
M
M
S
---
I
-
C
G
M
P
Y
D
T
-
L
H
D
I
I
G
M
D
D
S
K
K
V
G
S
L
R
E
Y
G
V
K
Y
K
M
V
D
L
K
D
-----------------------
G
K
V
D
I
N
T
V
K
E
E
L
--
K
-
K
D
D
S
I
K
L
I
H
I
Q
R
S
T
G
Y
G
W
R
K
S
L
R
I
A
E
I
A
E
I
I
K
S
I
R
E
V
N
E
N
V
I
V
F
V
D
N
C
Y
G
E
F
V
E
E
---
K
E
P
------
T
-----
D
V
G
A
D
I
I
A
G
S
L
I
K
N
I
G
-
G
G
I
A
T
T
G
G
Y
I
A
G
-
K
-
E
E
Y
V
T
Q
A
-
T
F
R
V
T
V
--
P
G
I
G
G
E
C
G
S
T
F
G
V
M
R
S
L
Y
E
-
G
--------
L
--
F
M
A
-
P
H
V
T
I
E
A
V
K
G
A
V
F
C
A
R
I
M
E
---
L
A
G
F
D
V
L
P
K
Y
N
D
K
R
T
D
I
I
Q
A
I
K
F
N
D
E
-
K
K
L
I
D
F
I
------
K
G
I
Q
T
A
S
P
V
D
S
F
V
Q
C
----------
K
V
I
M
A
A
G
T
F
V
Q
G
A
S
I
E
L
S
A
D
A
P
I
R
E
P
Y
I
G
Y
L
Q
G
G
L
T
F
D
H
A
K
L
G
V
L
I
A
L
S
K
L
I
-----
48
HHSearch
83.07
50%
-99
- C1 -
3I16
10
?
A:
[17-426]
--------
D
R
V
L
K
L
Y
E
T
A
M
N
D
I
Q
N
Q
F
K
I
L
D
D
I
R
E
F
N
Q
L
K
V
L
N
A
F
------
Q
E
E
R
I
S
E
A
H
F
T
N
S
S
G
Y
G
Y
G
D
I
G
---
R
---
D
S
L
---
D
A
V
Y
A
R
V
F
N
----
T
E
----
S
A
-
L
V
R
P
H
F
V
N
G
-
T
---
H
A
L
G
A
A
L
F
G
N
L
R
P
G
N
T
M
L
S
---
V
C
G
E
P
-
Y
D
T
-
L
H
D
V
I
G
I
T
E
N
S
N
M
G
S
L
K
E
F
G
I
N
Y
K
Q
V
D
L
K
E
------------
D
----------
G
K
P
N
L
E
E
I
E
K
V
L
--
K
-
E
D
E
S
I
T
L
V
H
I
Q
R
S
T
G
Y
G
W
R
R
A
L
L
I
E
D
I
K
S
I
V
D
C
V
K
N
I
R
K
D
I
I
C
F
V
D
N
C
Y
G
E
F
M
D
T
---
K
E
P
------
T
-----
D
V
G
A
D
L
I
A
G
S
L
I
K
N
I
G
-
G
G
I
A
P
T
G
G
Y
L
A
G
-
T
-
K
D
C
I
E
K
T
-
S
Y
R
L
T
V
--
P
G
I
G
G
E
C
G
S
T
F
G
V
V
R
S
M
Y
Q
-
G
--------
L
--
F
L
A
-
P
H
I
S
M
E
A
L
K
G
A
I
L
C
S
R
I
M
E
---
L
A
G
F
E
V
M
P
K
Y
D
E
K
R
S
D
I
I
Q
S
I
K
F
N
D
K
-
D
K
L
I
E
F
C
------
K
G
I
Q
T
G
S
P
I
D
S
F
V
S
C
E
P
W
D
M
---
T
D
Q
V
I
M
A
A
G
A
F
I
Q
G
S
S
I
E
L
S
A
D
A
P
I
R
E
P
Y
I
A
Y
L
Q
G
G
L
T
F
D
H
A
K
I
G
I
L
I
A
L
S
R
I
V
-----
4
PsiBlast_PDB
82.55
49%
-96
- C1 -
3HVY
5
?
D:
[22-426]
--------
E
L
Y
E
R
A
L
N
D
V
E
K
E
F
----
K
Y
Y
D
E
I
R
E
Y
N
Q
L
K
V
L
K
A
F
------
Q
E
E
R
I
S
E
S
H
F
T
N
S
S
G
Y
G
Y
N
D
I
G
---
R
---
D
S
L
---
D
R
V
Y
A
N
I
F
N
----
T
E
----
S
A
-
F
V
R
P
H
F
V
N
G
-
T
---
H
A
I
G
A
A
L
F
G
N
L
R
P
N
D
T
M
M
S
---
I
C
G
M
P
-
Y
D
T
-
L
H
D
I
I
G
M
D
D
S
K
K
V
G
S
L
R
E
Y
G
V
K
Y
K
M
V
D
L
-
K
------------
D
----------
G
K
V
D
I
N
T
V
K
E
E
L
KK
D
-
D
--
S
I
K
L
I
H
I
Q
R
S
T
G
Y
G
W
R
K
S
L
R
I
A
E
I
A
E
I
I
K
S
I
R
E
V
N
E
N
V
I
V
F
V
D
N
C
Y
G
E
F
V
E
E
---
K
E
P
------
T
-----
D
V
G
A
D
I
I
A
G
S
L
I
K
N
I
G
-
G
G
I
A
T
T
G
G
Y
I
A
G
-
K
-
E
E
Y
V
T
Q
A
-
T
F
R
V
T
V
--
P
G
I
G
G
E
C
G
S
T
F
G
V
M
R
S
L
Y
E
-
G
--------
L
--
F
M
A
-
P
H
V
T
I
E
A
V
K
G
A
V
F
C
A
R
I
M
E
---
L
A
G
F
D
V
L
P
K
Y
N
D
K
R
T
D
I
I
Q
A
I
K
F
N
D
E
-
K
K
L
I
D
F
I
------
K
G
I
Q
T
A
S
P
V
D
S
F
V
Q
C
----
E
A
W
Y
E
D
K
V
I
M
A
A
G
T
F
V
Q
G
A
S
I
E
L
S
A
D
A
P
I
R
E
P
Y
I
G
Y
L
Q
G
G
L
T
F
D
H
A
K
L
G
V
L
I
A
L
S
K
L
I
-----
47
HHSearch
56.77
76%
2
- C1 -
3HT4
-
?
A:
[1-416]
M
F
D
R
L
K
N
G
E
K
I
A
P
I
V
K
E
V
E
S
Q
I
T
E
V
H
K
R
A
D
E
V
I
E
S
N
Q
F
R
V
L
E
S
F
------
G
K
H
K
I
S
D
S
H
F
I
P
T
T
G
Y
G
Y
D
D
I
G
---
R
---
D
T
L
---
E
K
V
Y
A
D
V
F
G
----
A
E
----
A
G
-
L
V
R
P
Q
I
I
S
G
-
T
---
H
A
I
S
T
A
L
F
G
I
L
R
P
G
D
E
L
L
Y
---
I
T
G
K
P
-
Y
D
T
-
L
E
E
I
V
G
V
R
G
K
-
G
V
G
S
F
K
E
Y
N
I
G
Y
N
A
V
P
L
T
E
------------
G
----------
G
L
V
D
F
E
A
V
A
A
A
I
--
H
-
S
--
N
T
K
M
I
G
I
Q
R
S
K
G
Y
A
T
R
P
S
F
T
I
S
Q
I
K
E
M
I
A
F
V
K
E
I
K
P
D
V
V
V
F
V
D
N
C
Y
G
E
F
I
E
E
---
Q
E
P
------
C
-----
H
V
G
A
D
L
M
A
G
S
L
I
K
N
P
G
-
G
G
I
V
K
T
G
G
Y
I
V
G
-
K
-
E
Q
Y
V
E
A
C
-
A
Y
R
L
T
S
--
P
G
I
G
A
E
A
G
A
S
L
Y
S
L
Q
E
M
Y
Q
-
G
--------
F
--
F
L
A
-
P
H
V
A
G
Q
A
L
K
G
A
I
F
T
A
A
F
L
E
---
K
L
G
M
N
T
S
P
A
W
N
A
P
R
T
D
L
I
Q
S
V
Q
F
D
D
K
-
D
R
M
I
A
F
C
------
Q
A
I
Q
Y
A
S
P
I
N
S
H
F
T
P
Y
A
N
Y
M
P
G
Y
E
D
D
V
I
M
A
A
G
T
F
I
Q
G
A
S
I
E
L
S
A
D
G
P
I
R
P
P
Y
V
A
Y
V
Q
G
G
L
T
Y
S
H
V
K
I
A
I
C
S
A
I
D
E
L
I
E
----
8
PsiBlast_PDB
49.83
28%
-129
- C1 -
3VK3
1
MEGL_PSEPU
A:
[56-232]
----------------------------------------------------------------
G
H
F
Y
S
R
I
S
---
N
---
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
----
G
E
----
A
G
-
L
A
---
L
A
S
G
-
M
---
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
NT
L
Y
G
H
T
-
F
A
F
-
L
H
H
G
I
G
-----------
E
F
G
V
K
L
R
H
V
D
M
A
---------------------------
D
L
Q
A
L
E
A
A
M
--
T
-
P
--
A
T
R
V
I
Y
F
E
S
P
A
----
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
--
H
G
A
T
V
V
V
D
N
T
Y
C
T
P
Y
L
Q
----
R
P
------
L
-----
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
-
G
H
G
D
I
T
A
G
I
V
V
G
-
S
-
Q
A
L
V
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
49.26
28%
-135
- C1 -
3VK2
1
MEGL_PSEPU
A:
[56-232]
----------------------------------------------------------------
G
H
F
Y
S
R
I
S
---
N
---
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
----
G
E
----
A
G
-
L
A
---
L
A
S
G
-
M
---
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
NT
L
Y
G
H
T
-
F
A
F
-
L
H
H
G
I
G
-----------
E
F
G
V
K
L
R
H
V
D
M
A
---------------------------
D
L
Q
A
L
E
A
A
M
--
T
-
P
--
A
T
R
V
I
Y
F
E
S
P
A
----
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
--
H
G
A
T
V
V
V
D
N
T
Y
C
T
P
Y
L
Q
----
R
P
------
L
-----
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
-
G
H
G
D
I
T
A
G
I
V
V
G
-
S
-
Q
A
L
V
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
49.14
28%
-131
- C1 -
3VK4
2
MEGL_PSEPU
A:
[56-232]
----------------------------------------------------------------
G
H
F
Y
S
R
I
S
---
N
---
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
----
G
E
----
A
G
-
L
A
---
L
A
S
G
-
M
---
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
NT
L
Y
G
H
T
-
F
A
F
-
L
H
H
G
I
G
-----------
E
F
G
V
K
L
R
H
V
D
M
A
---------------------------
D
L
Q
A
L
E
A
A
M
--
T
-
P
--
A
T
R
V
I
Y
F
E
S
P
A
----
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
--
H
G
A
T
V
V
V
D
N
T
Y
C
T
P
Y
L
Q
----
R
P
------
L
-----
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
-
G
H
G
D
I
T
A
G
I
V
V
G
-
S
-
Q
A
L
V
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
49.01
18%
-97
- C1 -
1QGN
2
?
A:
[49-445]
-------
K
Y
A
S
F
L
N
S
D
G
S
V
A
I
H
A
G
E
R
L
G
R
G
I
V
T
D
A
I
T
T
P
V
V
N
T
S
A
Y
F
F
NK
T
S
E
L
I
D
F
K
E
K
R
R
A
-
S
F
E
Y
G
R
Y
G
N
P
T
T
---
V
V
L
---
E
E
K
I
S
A
L
E
G
----
A
E
----
S
T
-
L
L
M
A
---
S
G
-
M
---
C
A
S
T
V
M
L
L
A
L
V
P
A
G
G
H
I
V
T
---
T
T
D
C
Y
-
R
K
T
-
R
I
F
I
E
T
I
--------
L
P
K
M
G
I
T
A
T
V
I
D
P
A
---------------------------
D
V
G
A
L
E
L
A
L
--
N
Q
K
--
K
V
N
L
F
F
T
E
----
S
P
T
N
P
F
L
R
C
V
D
I
E
L
V
S
K
L
C
H
E
K
--
G
A
L
V
C
I
D
G
T
F
A
T
P
L
N
----
Q
K
A
------
L
-----
A
L
G
A
D
L
V
L
H
S
A
T
K
F
L
G
-
G
H
N
D
V
L
A
G
C
I
S
G
--
P
L
K
L
V
S
E
I
-
R
N
L
H
H
I
--
L
G
----
G
A
L
N
P
N
A
A
Y
L
I
I
R
-
G
--------
M
--
K
T
L
-
H
L
R
V
Q
Q
Q
N
S
T
A
L
R
M
A
E
I
L
E
A
HP
K
V
R
H
V
Y
Y
P
G
L
Q
S
H
P
E
H
H
I
A
K
K
Q
M
T
G
F
-
G
G
A
V
S
F
E
V
DGD
L
L
T
T
A
K
F
V
D
A
L
K
--
I
P
Y
I
A
P
S
F
G
G
C
E
S
I
V
D
Q
P
A
I
M
S
Y
W
D
L
S
Q
S
D
R
A
K
Y
G
I
M
D
N
L
V
R
F
S
F
G
V
E
D
F
D
D
L
K
A
D
I
L
Q
A
L
D
S
I
------
60
HHSearch
48.81
16%
-109
- C1 -
1YIZ
2
?
A:
[72-354]
----------------------------------------------------------------
Q
Y
T
R
G
-
F
G
---
H
---
P
R
L
---
V
Q
A
L
S
K
L
Y
S
----
Q
L
V
DRT
I
N
P
M
T
E
V
L
V
T
V
G
A
Y
---
E
A
L
Y
A
T
I
Q
G
H
V
D
E
G
D
E
V
I
I
---
I
-
E
P
F
-
F
D
C
-
Y
E
P
M
-----------
V
K
A
A
G
G
I
P
R
F
I
P
L
K
P
------------
N
KTGGTISSAD
W
V
L
D
N
N
E
L
E
A
L
F
--
N
-
E
--
K
T
K
M
I
I
I
N
-
T
P
H
N
P
L
G
K
V
M
D
R
A
E
L
E
V
V
A
N
L
C
K
K
W
--
N
V
L
C
V
S
D
E
V
Y
E
H
M
V
F
E
---
P
F
E
H
I
R
---
I
CTLPG
M
W
E
R
T
I
T
I
G
S
A
G
K
T
F
S
L
T
G
--
W
K
I
G
W
A
Y
G
-
P
-
E
A
L
L
K
N
L
-
Q
M
V
H
Q
N
--
C
V
Y
T
C
A
T
-
P
I
Q
E
A
I
A
V
G
F
E
-
T
E
L
K
R
LKSP
E
--
C
Y
F
-
N
S
I
S
G
E
L
M
A
K
R
D
Y
M
A
S
F
L
A
---
E
V
G
M
N
P
T
V
----
P
Q
G
G
Y
F
M
V
A
D
W
S
S
-------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
48.17
28%
-132
- C1 -
1UKJ
1
MEGL_PSEPU
A:
[56-232]
----------------------------------------------------------------
G
H
F
Y
S
R
I
S
---
N
---
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
----
G
E
----
A
G
-
L
A
---
L
A
S
G
-
M
---
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
NT
L
Y
G
C
T
-
F
A
F
-
L
H
H
G
I
G
-----------
E
F
G
V
K
L
R
H
V
D
M
A
---------------------------
D
L
Q
A
L
E
A
A
M
--
T
-
P
--
A
T
R
V
I
Y
F
E
S
P
A
----
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
--
H
G
A
T
V
V
V
D
N
T
Y
C
T
P
Y
L
Q
----
R
P
------
L
-----
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
-
G
H
G
D
I
T
A
G
I
V
V
G
-
S
-
Q
A
L
V
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
47.42
28%
-132
- C1 -
2O7C
1
MEGL_PSEPU
A:
[56-232]
----------------------------------------------------------------
G
H
F
Y
S
R
I
S
---
N
---
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
----
G
E
----
A
G
-
L
A
---
L
A
S
G
-
M
---
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
NT
L
Y
G
C
T
-
F
A
F
-
L
H
H
G
I
G
-----------
E
F
G
V
K
L
R
H
V
D
M
A
---------------------------
D
L
Q
A
L
E
A
A
M
--
T
-
P
--
A
T
R
V
I
Y
F
E
S
P
A
----
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
--
H
G
A
T
V
V
V
D
N
T
Y
C
T
P
Y
L
Q
----
R
P
------
L
-----
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
-
G
H
G
D
I
T
A
G
I
V
V
G
-
S
-
Q
A
L
V
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
47.10
28%
-126
- C1 -
1PG8
5
MEGL_PSEPU
A:
[56-232]
----------------------------------------------------------------
G
H
F
Y
S
R
I
S
---
N
---
P
T
L
N
L
L
E
A
R
M
A
S
L
E
G
----
G
E
----
A
G
-
L
A
---
L
A
S
G
-
M
---
G
A
I
T
S
T
L
W
T
L
L
R
P
G
D
E
V
L
L
G
NT
L
Y
G
C
T
-
F
A
F
-
L
H
H
G
I
G
-----------
E
F
G
V
K
L
R
H
V
D
M
A
---------------------------
D
L
Q
A
L
E
A
A
M
--
T
-
P
--
A
T
R
V
I
Y
F
E
S
P
A
----
N
P
N
M
H
M
A
D
I
A
G
V
A
K
I
A
R
K
--
H
G
A
T
V
V
V
D
N
T
Y
C
T
P
Y
L
Q
----
R
P
------
L
-----
E
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
S
-
G
H
G
D
I
T
A
G
I
V
V
G
-
S
-
Q
A
L
V
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
46.06
16%
-107
- C1 -
3B46
-
BNA3_YEAST
A:
[87-366]
----------------------------------------------------------------
Q
Y
S
P
T
-
R
G
---
R
---
P
S
L
---
I
N
S
L
I
K
L
Y
S
PIYN
T
E
----
L
K
-
A
E
N
V
T
V
T
T
G
A
N
---
E
G
I
L
S
C
L
M
G
L
L
N
A
G
D
E
V
I
V
---
F
-
E
P
F
-
F
D
Q
-
Y
I
P
N
I
-----------
E
L
C
G
G
K
V
V
Y
V
P
I
N
P
PKELDQRNTRGE
E
----------
W
T
I
D
F
E
Q
F
E
K
A
I
--
T
-
S
--
K
T
K
A
V
I
I
N
-
T
P
H
N
P
I
G
K
V
F
T
R
E
E
L
T
T
L
G
N
I
C
V
K
H
--
N
V
V
I
I
S
D
E
V
Y
E
H
L
Y
F
T
---
D
S
F
T
R
IAT-
L
S
P
E
--
I
G
Q
L
T
L
T
V
G
S
A
G
K
S
F
A
-
A
T
-
G
W
R
I
G
W
V
L
S
L
N
-
A
E
L
L
S
Y
A
-
A
K
A
H
T
R
--
I
C
F
A
S
P
S
P
L
Q
E
A
C
A
N
S
I
N
D
-
A
L
K
------
I
--
G
Y
F
-
E
K
M
R
Q
E
Y
I
N
K
F
K
I
F
T
S
I
F
D
---
E
L
G
L
P
Y
T
A
----
P
E
G
T
Y
F
V
L
V
D
F
S
K
-------------------------------------------------------------------------------------------------
39
Fugue
45.92
13%
-104
- C1 -
1FG7
1
HIS8_ECOLI
A:
[3-356]
---
T
V
T
I
T
D
L
A
R
E
N
V
R
N
L
T
P
Y
Q
S
A
R
R
L
G
G
N
G
D
V
W
------
L
N
A
N
------
E
Y
P
T
A
V
E
F
Q
L
T
Q
Q
T
L
N
R
Y
P
E
C
Q
---
P
---
K
A
V
---
I
E
N
Y
A
Q
Y
A
G
----
V
K
---------
P
E
Q
V
L
V
S
-
R
G
A
D
E
G
I
E
L
L
I
R
A
F
C
E
P
G
K
D
A
I
L
---
Y
C
-
P
P
-
T
Y
G
M
Y
S
V
S
A
E
T
I
G
V
E
C
R
T
-----------
V
P
T
L
D
------------
N
----------
W
Q
L
D
L
Q
G
I
S
D
K
L
----
D
--
G
V
K
V
V
Y
V
C
S
P
----
N
N
P
T
G
Q
L
I
N
P
Q
D
F
R
T
L
L
E
L
T
R
G
K
A
I
V
V
A
D
E
A
Y
I
E
F
C
P
Q
ASL
A
G
W
------
L
-----
A
E
Y
P
H
L
A
I
L
R
T
L
S
K
A
F
-
A
L
A
G
L
R
C
G
F
T
L
A
-
N
-
E
E
V
I
N
L
L
M
K
V
I
A
P
Y
--
P
L
S
T
P
V
A
D
I
A
A
Q
A
L
S
---
P
-
Q
--------
G
--
I
V
A
M
R
E
R
V
A
Q
I
I
A
E
R
E
Y
L
I
A
A
L
K
---
E
I
P
C
V
E
Q
V
F
---
D
S
E
T
N
Y
I
L
A
R
F
K
A
S
-
S
A
V
F
K
S
L
------
W
D
-------
Q
G
I
I
L
R
D
Q
N
K
Q
P
S
L
S
G
C
L
R
I
T
V
G
T
--------------------------------
R
E
E
S
Q
R
V
I
D
A
L
R
A
E
Q
V
-
67
HHSearch
45.44
15%
-90
- C1 -
1GD9
2
?
A:
[26-340]
-------------------------
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
------
K
E
Y
A
K
-
E
A
L
D
K
G
L
T
H
Y
G
P
N
-
I
G
---
L
---
L
E
L
---
R
E
A
I
A
E
K
L
K
K
QNG
I
E
----
A
D
P
K
T
E
I
M
V
L
L
G
A
N
---
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
---
P
-
T
P
A
-
F
V
S
-
Y
A
P
A
V
-----------
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
ED----------
E
----------
F
R
L
N
V
D
E
L
K
K
Y
V
--
T
-
D
--
K
T
R
A
L
I
I
N
-
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
--
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
---
D
A
R
H
Y
S
IAS
L
DG---
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
-
M
T
-
G
W
R
L
G
F
V
A
A
-
P
-
S
W
I
I
E
R
M
-
V
K
F
Q
M
Y
N
A
T
C
P
V
-
T
F
I
Q
Y
--
A
A
A
K
A
L
K
D
E
--------
R
S
W
K
A
V
-
E
E
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
---
E
M
G
L
P
T
V
----
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
G
L
T
S
K
K
F
S
------
E
L
M
L
------------------------------------------------------------------------------
18
PsiBlast_PDB
44.90
25%
-129
- C1 -
4P7Y
1
?
A:
[53-234]
---------------------------------------------------------------
S
G
Y
I
F
T
R
L
G
---
N
P
T
T
D
A
L
---
E
K
K
L
A
V
L
E
R
----
G
E
----
A
G
-
L
A
T
A
---
S
G
-
I
---
S
A
I
T
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
------------
S
-
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
G
I
N
V
S
F
V
D
A
A
K
------------
P
---------------
E
E
I
R
A
A
M
--
R
-
P
--
E
T
K
V
V
Y
I
E
T
P
---
A
N
-
P
T
L
S
L
V
D
I
E
T
V
A
G
I
A
H
Q
--
Q
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
----
Q
P
------
L
-----
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
G
D
V
I
G
G
I
I
V
G
-
K
-
Q
E
F
I
D
Q
A
-
R
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------