@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu17630: (2016-06-28 )
MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQLDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPNVFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNAILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIREDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIMYYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTALLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSGISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEELEEHFRSRHDHNTPEQSVIEV
Atome Classification :
(20 SA)
.........10..-......----20.-.......30........----40-------------.------.------...--------------..-----.50.--.....-------..60........70........80........90...--.---...------------------.------------------100-.........-110.......120.......130.......140.......150.......160..---.----....---..170--........180.......190.......200...-...-..210-.......220.......230.......240..-....-.-250.......260.-------...---...270.......280.......290.......300.......310.......320.......330.......340.......350------........360-......-.370.......380.......390.......400.......410-----.------......------.420.......430.......440.......450......-.460.......470
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDM
N
E
HRN
R
R
L
K
L
-
I
M
I
SAT----FG
G
-
L
L
F
GYDTGVINGALPFM----AR-------------P------D------QLD--------------LT-----PV
T
E
--
G
L
V
T
S
-------
I
L
L
L
G
A
A
F
G
A
L
L
C
G
R
L
A
D
R
YGR
R
K
M
I
L
N
L
S
F
L
F
F
L
A
S
--
L
---GTA------------------L------------------A---
P
N
V
F
I
M
A
V
F
-
R
F
L
L
G
LAVG
G
A
S
A
M
V
P
A
F
L
A
E
MA
P
H
E
K
RG
R
M
VTQN
E
L
M
I
V
G
G
Q
F
L
A
Y
V
F
N
A
--
I
L
---
G
----
V
T
MA---NT
G
H
---
V
W
R
Y
M
L
V
I
C
A
V
P
A
I
M
L
F
A
S
M
LKVPESPRWL-ISK-GK
N
-
S
E
A
L
R
-
V
L
K
Q
I
R
E
D
K
R
A
E
A
E
C
R
E
I
Q
E
A
V
E
KDTA
L
E
K
AS-LKDF-
S
-
T
P
W
L
R
R
L
L
W
I
G
I
G
V
-------
A
I
V
---
N
Q
ITG
V
N
S
I
M
Y
Y
G
T
Q
I
L
K
ESGFG
T
K
A
A
L
I
A
N
IG
N
G
L
I
S
V
I
A
V
I
F
G
I
W
L
V
GKVRRR
P
I
L
L
I
GLA
G
T
T
T
A
L
L
L
I
A
I
F
S
I
V
LDGS
M
A
L
-------
P
Y
V
V
L
S
L
T
V
L
F
-
L
A
F
M
Q
G-
C
V
G
P
V
T
W
L
V
I
A
E
I
F
P
Q
R
L
R
G
LGS
G
I
S
V
F
F
L
W
I
L
N
F
V
I
G
F
A
F
P
I
------
L
------
L
S
S
VG
L
------
S
F
T
F
F
I
F
V
A
L
G
V
L
A
I
G
F
V
Y
K
FMPETKGR
T
L
E
E
L
E
E
H
F
R
SR-HDHNTP
E
Q
SVIEV
45
Fugue
77.59
32%
-124
- C1 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
-----
Y
N
S
S
Y
I
F
S
-
I
T
L
V
A
T
----
L
G
G
-
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
----
N
T
-------------
V
FVAPQN
L
------
S
E
S
--------------
A
A
-----
N
S
L
L
--
G
F
C
V
A
-------
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
--
V
---
G
S
A
WPELGFTSINPDNTVPVY
L
------------------
A
---
G
Y
V
P
E
F
V
I
Y
-
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
--
F
I
---
A
----
R
S
G
D
---
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
-
M
S
R
-
G
K
Q
-
E
Q
A
E
G
-
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
R
L
-
L
M
F
-------
G
V
G
V
I
V
I
G
V
M
L
-------
S
I
F
---
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
-----------
G
I
V
A
L
L
S
M
L
F
Y
-
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
N
S
W
L
------
V
A
H
F
H
N
------
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
----------------
2
PsiBlast_PDB
75.64
32%
-99
- C1 -
4GBY
5
XYLE_ECOLI
A:
[5-475]
------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
----
L
G
G
-
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
-------------
P
------
Q
------
N
L
S
--------------
E
S
-----
A
A
N
S
L
L
G
F
C
V
A
-------
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
--
V
---
G
S
A
WPELGFTSINPDNTVPVY
L
------------------
A
---
G
Y
V
P
E
F
V
I
Y
-
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
--
F
I
---
A
R
SGD
A
S
W
L
---
N
T
D
G
----
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
-
M
S
R
-
G
K
Q
-
E
Q
A
E
G
-
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
---------------
R
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
---
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
-----
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
-------
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
------
M
------
D
K
N
S
W
L
V
A
H
FHN
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
--------------------
4
PsiBlast_PDB
75.51
32%
-100
- C1 -
4GC0
5
XYLE_ECOLI
A:
[5-475]
------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
----
L
G
G
-
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
-------------
P
------
Q
------
N
L
S
--------------
E
S
-----
A
A
N
S
L
L
G
F
C
V
A
-------
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
--
V
---
G
S
A
WPELGFTSINPDNTVPVY
L
------------------
A
---
G
Y
V
P
E
F
V
I
Y
-
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
--
F
I
---
A
R
S
GD
A
S
W
L
---
N
T
D
G
----
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
-
M
S
R
-
G
K
Q
-
E
Q
A
E
G
-
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
---------------
R
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
---
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
-----
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
-------
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
------
M
------
D
K
N
S
W
L
V
A
H
FHN
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
--------------------
3
PsiBlast_PDB
75.47
32%
-98
- C1 -
4GBZ
5
XYLE_ECOLI
A:
[5-475]
------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
----
L
G
G
-
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
-------------
P
------
Q
------
N
L
S
--------------
E
S
-----
A
A
N
S
L
L
G
F
C
V
A
-------
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
--
V
---
G
S
A
W
PELGFTSINPDNTVPVY
L
------------------
A
---
G
Y
V
P
E
F
V
I
Y
-
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
--
F
I
---
A
R
S
GD
A
S
W
L
---
N
T
D
G
----
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
-
M
S
R
-
G
K
Q
-
E
Q
A
E
G
-
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
---------------
R
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
---
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
-----
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
-------
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
------
M
------
D
K
N
S
W
L
V
A
H
FHN
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
--------------------
22
PsiBlast_CBE
74.77
31%
-113
- C1 -
4JA3
2
XYLE_ECOLI
B:
[7-471]
-------
S
S
Y
I
F
S
-
I
T
L
V
A
T
----
L
G
G
-
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
-------------
P
------
Q
------
N
L
S
--------------
E
S
-----
A
A
N
S
L
L
G
F
C
V
A
-------
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
--
V
---
G
S
A
WPELGF
T
S
I
N
P
D
N
T
V
P
VY
L
------------------
A
---
G
Y
V
P
E
F
V
I
Y
-
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
--
F
I
---
A
R
S
GD
A
S
W
L
---
N
T
D
G
----
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
-
M
S
R
-
G
K
Q
-
E
Q
A
E
G
-
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
R
--------------------------
G
V
I
V
I
G
V
M
L
S
I
F
---
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
------
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
-----
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
-------
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
---
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
------
M
------
D
K
N
S
--HN----
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
------------------------
1
PsiBlast_PDB
74.49
36%
-153
- C1 -
4LDS
-
?
A:
[22-427]
---------------------------------
D
N
G
V
I
S
G
A
L
L
F
I
----
H
K
---------------------------
D
I
P
--------------
L
N
-----
S
T
T
E
--
G
I
V
V
S
-------
S
M
L
I
G
A
I
V
G
A
G
S
S
G
P
L
A
D
K
L
G
R
R
R
L
V
M
L
I
A
I
V
F
I
I
G
A
--
L
---
I
L
A
------------------
A
------------------
S
---
T
N
L
A
L
L
I
I
G
-
R
L
I
I
G
L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
N
Q
L
M
I
T
I
G
I
L
A
A
Y
L
V
N
-------------
Y
A
F
A
---
D
I
-
E
---
G
W
R
W
M
L
G
L
A
V
V
P
S
V
I
L
L
V
G
I
Y
F
M
P
E
S
P
R
W
L
-
L
E
N
-
R
N
E
-
E
A
A
R
Q
-
V
M
K
I
T
Y
D
D
S
E
I
D
K
E
L
K
E
M
K
E
I
----
N
A
I
S
E
S
T
-
W
T
V
I
-
K
-
S
P
W
L
G
R
I
L
I
V
G
C
I
F
-------
A
I
F
---
Q
Q
F
I
G
I
N
A
V
I
F
Y
S
S
S
I
F
A
K
A
G
L
G
E
A
A
S
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
D
R
K
K
L
L
V
G
G
N
I
G
M
I
A
S
L
L
I
M
A
I
L
-
I
W
T
I
G
I
A
S
S
-------
A
W
I
I
I
V
C
L
S
L
F
-
I
V
F
F
G
I
-
S
W
G
P
V
L
W
V
M
L
P
E
L
F
P
M
R
A
R
G
A
A
T
G
I
S
A
L
V
L
N
I
G
T
L
I
V
S
L
F
F
P
I
------
L
------
S
D
A
L
S
T
------
E
W
V
F
L
I
F
A
F
I
G
V
L
A
M
I
F
V
I
K
F
L
P
E
T
R
G
---------------------------
8
PsiBlast_PDB
74.08
27%
-96
- C1 -
4ZW9
4
GTR3_HUMAN
A:
[39-490]
------------------
A
T
----
I
G
S
-
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
----
K
E
-------------
F
------
I
------
T
K
T
--------------
L
T
D
K
GNA
P
P
S
E
--
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
--
C
---
F
M
G
------------------
L
CKV---------------
A
---
K
S
V
E
M
L
I
L
G
-
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
EF
I
L
---
G
------------
S
E
E
---
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
-
K
E
E
-
E
N
A
K
Q
-
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
-
R
-
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
-------
Q
L
S
---
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
--
V
Q
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
-------
S
F
V
C
I
G
A
I
L
V
F
-
V
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
------
A
H
Y
L
G
-------
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
--------------
9
PsiBlast_PDB
72.92
27%
-95
- C1 -
4ZWB
1
GTR3_HUMAN
A:
[39-490]
------------------
A
T
----
I
G
S
-
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
----
K
E
-------------
F
------
I
------
T
K
T
--------------
L
T
D
K
GNA
P
P
S
E
--
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
--
C
---
F
M
G
------------------
L
CKV---------------
A
---
K
S
V
E
M
L
I
L
G
-
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
EF
I
L
---
G
------------
S
E
E
---
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
-
K
E
E
-
E
N
A
K
Q
-
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
-
R
-
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
-------
Q
L
S
---
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
--
V
Q
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
-------
S
F
V
C
I
G
A
I
L
V
F
-
V
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
------
A
H
Y
L
G
-------
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
--------------
10
PsiBlast_PDB
71.98
27%
-96
- C1 -
4ZWC
3
GTR3_HUMAN
A:
[39-490]
------------------
A
T
----
I
G
S
-
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
----
K
E
-------------
F
------
I
------
T
K
T
--------------
L
T
D
K
GNA
P
P
S
E
--
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
--
C
---
F
M
G
------------------
L
CKV---------------
A
---
K
S
V
E
M
L
I
L
G
-
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
EF
I
L
---
G
------------
S
E
E
---
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
-
K
E
E
-
E
N
A
K
Q
-
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
-
R
-
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
-------
Q
L
S
---
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
--
V
Q
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
-------
S
F
V
C
I
G
A
I
L
V
F
-
V
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
------
A
H
Y
L
G
-------
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
--------------
24
HHSearch
71.40
35%
-142
- C1 -
4LDS
-
?
A:
[15-409]
-------------------------
G
G
-
L
L
Y
G
Y
D
N
G
V
I
S
G
A
L
L
F
I
----
H
---------------------
K
------
D
I
P
--------------
L
N
-----
S
T
T
E
--
G
I
V
V
S
-------
S
M
L
I
G
A
I
V
G
A
G
S
S
G
P
L
A
D
K
L
G
R
R
R
L
V
M
L
I
A
I
V
F
I
I
G
A
--
L
---
I
L
A
------------------
A
------------------
S
---
T
N
L
A
L
L
I
I
G
-
R
L
I
I
G
L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
N
Q
L
M
I
T
I
G
I
L
A
A
Y
L
V
N
Y
--
A
F
---
A
----
D
--------
I
E
---
G
W
R
W
M
L
G
L
A
V
V
P
S
V
I
L
L
V
G
I
Y
F
M
P
E
S
P
R
W
L
-
L
E
N
-
R
N
E
-
E
A
A
R
Q
-
V
M
K
I
T
Y
D
D
S
E
I
D
K
E
----
L
K
E
M
K
E
I
N
A
I
S
E
S
T
-
W
T
V
I
-
K
-
S
P
W
L
G
R
I
L
I
V
G
C
I
F
-------
A
I
F
---
Q
Q
F
I
G
I
N
A
V
I
F
Y
S
S
S
I
F
A
K
A
G
L
G
E
A
A
S
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
D
R
K
K
L
L
V
G
G
N
I
G
M
I
A
S
L
L
I
M
A
I
L
I
W
T
I
G
I
A
--
S
-------
S
A
W
I
I
I
V
C
L
S
L
-
F
I
V
F
F
G
I
S
W
G
P
V
L
W
V
M
L
P
E
L
F
P
M
R
A
R
G
A
A
T
G
I
S
A
L
V
L
N
I
G
T
L
I
V
S
L
F
F
P
I
------
L
------
S
D
A
L
S
T
------
E
W
V
F
L
I
F
A
F
---------------------------------------------
7
PsiBlast_PDB
71.12
27%
-103
- C1 -
5C65
8
GTR3_HUMAN
A:
[17-469]
------------------
A
T
----
I
G
S
-
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
----
K
E
-------------
F
------
I
------
Q
K
T
--------------
L
T
D
KGNA
P
P
S
E
--
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
--
C
---
F
M
G
------------------
L
C
KV---------------
A
---
K
S
V
E
M
L
I
L
G
-
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
EF
I
L
---
G
------------
S
E
E
---
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
-
K
E
E
-
E
N
A
K
Q
-
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
V
L
E
L
F
-
R
-
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
-------
Q
L
S
---
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
------
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
----
M
-------
S
F
V
C
I
G
A
I
L
V
F
-
V
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
------
A
H
Y
L
G
-------
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A-------------
46
Fugue
71.00
33%
-121
- C1 -
4QIQ
1
XYLE_ECOLI
A:
[7-470]
--------
S
Y
I
F
S
-
I
T
L
V
A
T
----
L
G
G
-
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
----
N
T
V
FVA---------
P
------
Q
------
N
L
S
--------------
E
S
-----
A
A
N
S
L
L
G
F
C
V
A
-------
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
--
V
---
G
S
A
WPELGFTSINPDNTVPVY
L
------------------
A
---
G
Y
V
P
E
F
V
I
Y
-
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
--
F
I
A
R
S
G
----
D
A
S
W
---
L
N
T
D
---
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
-
M
T
---------------------
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
R
L
---------------
L
M
F
G
V
G
V
I
V
I
G
V
M
L
-------
S
I
F
---
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
P
G
----------
I
V
A
L
L
S
M
L
F
Y
V
-
A
A
F
A
M
S
-
W
-
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
------
M
DKN
S
W
L
V
A
H
F
H
N
------
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
------------------------
6
PsiBlast_PDB
70.72
29%
-95
- C1 -
4PYP
1
GTR1_HUMAN
A:
[11-455]
---------
R
L
M
L
-
A
V
G
G
A
V
----
L
G
S
-
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
----
E
E
F
Y
T
Q
T
W
V
H
R
Y---
G
------
E
------
S
I
L
--------------
P
T
-----
T
L
T
T
L
W
S
L
S
V
A
-------
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
---
G
F
S
------------------
K
------------------
L
---
G
K
S
F
E
M
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
----
L
---
D
----
S
I
M
G
---
N
K
-
D
---
L
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
-
N
E
E
-
N
R
A
K
S
-
V
L
K
K
L
R
G
T
A
D
V
T
H
D
L
Q
E
M
K
E
E
S
R
Q
M
M
R
E
K
K
V
T
I
L
E
L
F
-
R
-
S
P
A
Y
R
Q
P
I
L
I
A
V
V
L
-------
Q
L
S
---
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
G
--
V
Q
Q
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
Q
R
A
G
R
R
T
L
H
L
I
G
L
A
G
M
A
G
C
A
I
L
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
-------
S
Y
L
S
I
V
A
I
F
G
F
-
V
A
F
F
E
V
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
------
V
------
E
Q
L
C
G
-------
P
Y
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
-----------------------------
5
PsiBlast_PDB
70.54
31%
-126
- C1 -
4JA4
1
XYLE_ECOLI
A:
[9-475]
---------
Y
I
F
S
-
I
T
L
V
A
T
----
L
G
G
-
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
-------------
P
------
Q
------
N
L
S
--------------
E
S
-----
A
A
N
S
L
L
G
F
C
V
A
-------
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
--
V
---
G
S
A
W
PELGF
T
S
I
N
P
D
N
T
V
PVY
L
------------------
A
---
G
Y
V
P
E
F
V
I
Y
-
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
--
F
I
---
A
RSGD
A
S
W
L
---
N
T
D
G
----
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
-
M
-----
Q
-
E
Q
A
E
G
-
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
-----------------------
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
---
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
-----------
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
-----
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
-------
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
------
M
------
D
K
N
S
W
-N-----
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
--------------------
20
PsiBlast_CBE
70.10
31%
-123
- C1 -
4JA4
1
XYLE_ECOLI
C:
[9-475]
---------
Y
I
F
S
-
I
T
L
V
A
T
----
L
G
G
-
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
NTVF
V
A
-------------
P
------
Q
------
N
L
S
--------------
E
S
-----
A
A
N
S
LL
G
F
C
V
A
-------
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
--
V
---
G
S
A
WPELGFTSINPTVPVY--
L
------------------
A
---
G
Y
V
P
E
F
V
I
Y
-
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
--
F
I
---
A
RSGD
A
S
W
L
---
N
T
D
G
----
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
-
M
-----
Q
-
E
Q
A
E
G
-
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
-----------------------
M
F
G
V
G
V
IVIGVML
S
I
F
---
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
------------
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
-----
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
-------
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
------
M
------
D
K
N
---------
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
--------------------
21
PsiBlast_CBE
69.92
31%
-124
- C1 -
4JA4
1
XYLE_ECOLI
B:
[9-475]
---------
Y
I
F
S
-
I
T
L
V
A
T
----
L
G
G
-
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
-------------
P
------
Q
------
N
L
S
--------------
E
S
-----
A
A
N
S
L
L
G
F
C
V
A
-------
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
--
V
---
G
S
A
W
PELGF
T
S
I
N
P
DNPVY--
L
------------------
A
---
G
Y
V
P
E
F
V
I
Y
-
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
--
F
I
---
A
RSGD
A
S
W
L
---
N
T
D
G
----
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
-
M
-----
Q
-
E
Q
A
E
G
-
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
H
G
-----------------------
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
---
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
------------
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
-----
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
Q
A
-------
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
------
M
------
D
K
N
S
W
-N-----
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
--------------------
23
HHSearch
69.69
28%
-101
- C1 -
4PYP
1
GTR1_HUMAN
A:
[17-455]
----------------
G
G
A
V
----
L
G
S
-
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
----
E
E
-------------
F
Y
T
Q
T
W
V
H
------
R
Y
G
E
S
I
L
P
T
--------
T
L
-----
T
T
L
W
--
S
L
S
V
A
-------
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
--
V
---
L
M
G
------------------
F
------------------
S
KLG
K
S
F
E
M
L
I
L
G
-
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
L
--
D
S
---
I
------
M
----
G
N
K
D
---
L
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
-
L
I
N
R
N
E
E
-
N
R
A
K
S
-
V
L
K
K
L
R
G
T
A
D
V
T
H
D
L
Q
E
M
K
E
E
S
R
Q
M
M
R
E
K
K
V
T
-
I
L
E
L
F
R
-
S
P
A
Y
R
Q
P
I
L
I
A
V
V
L
-------
Q
L
S
---
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
G
V
Q
--
Q
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
Q
R
A
G
R
R
T
L
H
L
I
G
L
A
G
M
A
G
C
A
I
L
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
-------
S
Y
L
S
I
V
A
I
F
G
F
-
V
A
F
F
E
V
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
------
V
------
E
Q
L
C
G
P
-------
Y
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
-----------------------------
26
HHSearch
67.95
27%
-96
- C1 -
4ZW9
4
GTR3_HUMAN
A:
[37-452]
----------------
T
V
A
T
----
I
G
S
-
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
----
K
E
---------------------------
F
I
T
K
T
L
T
D
K
GNAPPS
E
V
L
L
-----
T
S
L
W
--
S
L
S
V
A
-------
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
--
C
---
F
M
G
------------------
L
CKV---------------
A
---
K
S
V
E
M
L
I
L
G
-
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
--
E
F
---
I
----
L
------
G
S
E
E
---
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
-
L
I
N
-
R
K
E
E
E
N
A
K
Q
-
I
L
Q
R
L
W
G
T
Q
D
V
S
Q
D
I
Q
E
M
K
D
E
S
A
R
M
S
Q
E
K
Q
V
T
-
V
L
E
L
-
F
R
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
-------
Q
L
S
---
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
--
G
V
Q
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
L
G
G
M
A
F
C
S
T
L
M
T
V
S
L
L
L
K
D
N
Y
N
G
M
-------
S
F
V
C
I
G
A
I
L
V
F
-
V
A
F
F
E
I
-
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
L
L
F
P
S
------
A
------
A
H
Y
L
G
A
------
Y
-----------------------------------------------------
28
HHSearch
67.90
30%
-122
- C1 -
4GC0
4
XYLE_ECOLI
A:
[13-429]
--------------
I
T
L
V
A
T
----
L
G
G
-
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
----
N
T
-------------
V
------
F
VAPQNL
S
E
S
--------------
A
A
-----
N
S
L
L
--
G
F
C
V
A
-------
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
--
V
---
G
S
A
------------------
W
PELGFTSINPDNTVPVYL
A
---
G
Y
V
P
E
F
V
I
Y
-
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
--
F
I
---
A
----
R
S
G
D
A
S
W
L
N
T
D
---
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
-
M
S
R
-
G
K
Q
-
E
Q
A
E
G
-
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
----
V
Q
E
I
K
H
S
L
D
H
G
R
K
T
-
G
G
R
L
-
L
--
M
F
G
V
G
V
I
V
I
G
V
M
L
-------
S
I
F
---
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
Y
T
--
Q
A
--
P
-------
G
I
V
A
L
L
S
M
L
F
Y
-
V
A
A
F
A
M
-
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
------
M
------------------------------------------------------------------------
11
PsiBlast_PDB
67.16
27%
-110
- C1 -
4YB9
-
GTR5_BOVIN
D:
[19-462]
-----------------
L
A
T
LIAA
F
G
S
S
F
Q
Y
G
Y
N
V
A
A
I
N
S
P
S
E
F
M
----
K
D
FYAYTYYDRVGEY
M
------
N
------
E
F
Y
--------------
L
T
------
L
L
W
--
S
V
T
V
S
-------
M
F
P
F
G
G
F
L
G
S
L
M
V
G
P
L
V
N
N
L
G
R
K
G
T
L
L
F
N
N
I
F
S
I
V
P
A
--
L
LMG
F
S
E
------------------
L
------------------
A
---
K
S
F
E
M
I
I
V
A
-
R
V
L
V
G
I
C
A
G
L
S
S
N
V
V
P
M
Y
L
G
E
L
A
P
K
N
W
R
G
A
L
G
V
V
P
Q
L
F
I
T
I
G
I
L
V
A
Q
I
F
G
----
L
---
R
----
S
L
L
A
---
N
E
-
E
---
G
W
P
I
L
L
G
L
T
G
I
P
A
V
L
Q
L
L
F
L
P
F
F
P
E
S
P
R
Y
L
-
L
I
Q
-
K
K
D
-
E
A
A
A
K
S
A
L
R
R
L
-------
A
E
I
E
E
I
L
E
E
D
R
A
E
K
A
V
G
F
I
S
V
L
K
L
F
-
K
----
M
R
S
L
R
W
Q
V
I
S
I
-------
I
V
L
MAG
Q
Q
L
S
G
V
N
A
I
Y
Y
Y
A
D
Q
I
Y
L
S
A
G
V
N
E
D
D
V
Q
Y
V
T
A
G
T
G
A
V
N
V
L
I
T
V
C
A
I
F
V
V
E
L
M
G
R
R
F
L
L
L
L
G
F
S
V
C
F
T
A
-------
C
C
V
L
T
G
A
L
A
L
QDVISWM
P
Y
V
S
I
A
C
V
I
S
Y
-
V
I
G
H
A
L
-
G
P
S
P
I
P
A
L
L
V
T
E
I
F
L
Q
S
S
R
P
A
A
Y
M
V
A
G
T
V
H
W
L
S
N
F
T
V
G
L
V
F
P
F
------
I
------
Q
V
G
L
G
-------
A
Y
S
F
V
I
F
A
V
I
C
L
L
T
T
V
Y
I
F
L
I
I
P
E
------------------------------