@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu18000: (2016-06-28 )
MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSKLPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVPAVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERNAERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGTDSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLALKVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYLRLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLIPLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSCTNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELGFNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLASPPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRKEYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVGKFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANIRIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAAKGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDETVRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS
Atome Classification :
(20 SA)
.........10........20........30.-.......40........50........60........70........80...-.....90........100.......110.......120.......130.......140.......150.......160......-.170.......180.......190.......200.......210-...-....220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.....--..360..-......370.......380.......390.......400.......410.......420.......430.......440.......450.......460........470.......480.......490.......500.......510.......520...--.-...530.......540.......550..--...-..560.......570.......580.......590.......600.......610.......620.......630.......640-.......650.......660.......670.......680.......690.......700.......710.......720.......730..-.....740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.-......860.......870.......880.......890.......900.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAN
E
Q
K
T
A
A
K
D
V
F
Q
A
R
K
TFTTNG
K
T
Y
H
Y
Y
S
L
K
-ALEDSGIG
K
V
SKL
P
Y
S
I
K
V
L
L
E
S
V
L
R
QVDG
F
V
I
K
K
E
H
V
E
N
L
A
K
WGTAELKDI-DVPFKP
S
R
V
I
L
Q
DFTG
V
P
A
V
V
D
L
A
S
L
R
K
A
M
A
AVGGDPDKINPEI
P
V
D
L
V
IDH
S
V
Q
VDKAGTED
A
L
A
V
N
M
D
L
E
FER
N
A
E
R
Y
K
F
L
S
-
W
A
K
K
A
FNNYQAVPPATG
I
V
H
QV
N
L
E
F
L
A
S
V
V
H
A
I
EEDG
E
L
V
TYP-DTL-VGTDSH
T
T
M
I
N
G
I
G
V
L
GWGVGGIEAEAGMLGQPSYFP
V
P
E
V
I
G
A
K
L
V
GKLPNGT
T
A
T
D
L
A
L
K
V
T
Q
V
L
R
EKG
V
V
G
K
F
V
E
F
FGPGIAELPLA
D
R
A
T
I
A
NMAPEYGATCGFFPV
D
E
E
A
L
N
Y
L
RLTGRDP
E
H
I
D
V
V
E
A
Y
C
RSN
G
L
F
--YTPD-AE-DPQF
T
D
V
V
E
I
D
L
S
Q
I
EANLSGPKRPQDLI
P
L
S
A
M
Q
E
T
F
K
K
Q
LVSPAGNQGFGLNAEEEN
K
E
I
K
F
K
L
LNGE
E
T
V
M
KTG
A
I
A
I
A
A
I
TSCTNTSN
P
Y
V
L
I
G
-
A
G
L
V
A
K
K
A
V
E
LGLKVP
N
Y
V
K
TSLAPG
S
K
V
V
T
G
Y
LVNS
G
L
L
P
Y
M
K
E
LGF
N
L
VGYGCTTCIGNSGP--L-
S
P
E
I
E
E
A
V
AKN
D
L
L
I
T
S
VLSGNRNFE
G
R
--
I
H
P
-
L
VKGNYLAS
P
P
L
V
V
A
Y
A
L
A
G
T
V
N
I
N
L
KTDPIGVGKDG
Q
N
V
Y
FNDIWP
S
M
D
E
I
N
A
L
V
K
QTV
T
P
E
L
F
R
K
E
Y
E
T
VFDDNKRWNEIE
T
T
-
D
E
A
L
Y
K
WDNDSTYIQNPP
F
F
E
EMSVEPGKVEPLKG
L
R
V
V
GKFGDSVTTDHISPAGAIGKDTPAG
K
Y
L
Q
EKGVSPRD
F
N
S
YGSRRGN
H
E
V
M
M
R
-
G
T
F
A
N
I
R
I
K
NQIAPGTEGG
F
T
T
YWPTG
E
V
T
S
I
Y
D
A
C
M
K
YKEDKT
G
L
V
V
L
AGKDYGMGSSRDWAAKGT
N
L
L
G
I
R
T
V
I
A
E
S
F
E
R
I
H
RS
N
L
V
F
M
G
VL
P
L
Q
FKQGENADTLGLTG
K
E
V
I
E
VDV-DETVRPR
D
L
V
T
V
R
A
INEDGN
V
T
T
F
E
A
V
V
RFDS
E
V
E
I
D
Y
Y
RHG
G
I
L
Q
M
V
L
R
E
K
MKQS
21
PsiBlast_CBE
85.97
53%
-23
- C3 -
2B3Y
4
ACOC_HUMAN
B:
[20-888]
---------------------------
F
F
N
L
N
-
K
L
E
D
S
R
Y
G
R
---
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
V
K
K
Q
D
I
E
N
I
L
H
W
N
V
T
Q
H
K
N
I
-
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
-
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
--
F
D
Q
D
G
--
Y
Y
Y
P
-
D
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
F
RD
F
N
D
P
-
S
Q
-
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
Q
G
F
K
G
F
Q
V
A
P
E
H
H
N
D
H
K
T
F
-
I
Y
D
N
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
-
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
P
--
L
-
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
--
V
H
P
-
N
T
R
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
A
L
A
T
P
-
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
-
G
T
F
A
N
I
R
L
L
N
R
F
L
-
N
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
I
-
P
E
N
L
K
P
Q
M
K
V
Q
V
K
L
--
D
T
G
K
--
T
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
K
M
A
K
--
1
PsiBlast_PDB
85.92
53%
-22
- C3 -
2B3X
3
ACOC_HUMAN
A:
[20-888]
---------------------------
F
F
N
L
N
-
K
L
E
D
S
R
Y
G
R
---
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
V
K
K
Q
D
I
E
N
I
L
H
W
N
V
T
Q
H
K
N
I
-
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
-
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
--
F
D
Q
D
G
--
Y
Y
Y
P
-
D
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
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A
V
M
L
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Q
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G
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V
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K
F
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F
F
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G
V
A
Q
L
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A
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P
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V
M
L
G
-
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
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G
S
G
V
V
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Y
Y
L
Q
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Q
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G
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C
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T
C
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N
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G
P
--
L
-
P
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P
V
V
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A
I
T
Q
G
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L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
--
V
H
P
-
N
T
R
A
N
Y
L
A
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P
P
L
V
I
A
Y
A
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A
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I
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K
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N
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S
W
N
A
L
A
T
P
-
S
D
K
L
F
F
W
N
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P
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F
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N
L
T
L
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R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
I
-
P
E
N
L
K
P
Q
M
K
V
Q
V
K
L
--
D
T
G
K
--
T
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
K
M
A
K
--
2
PsiBlast_PDB
85.67
53%
-23
- C3 -
2B3Y
4
ACOC_HUMAN
A:
[20-888]
---------------------------
F
F
N
L
N
-
K
L
E
D
S
R
Y
G
R
---
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
V
K
K
Q
D
I
E
N
I
L
H
W
N
V
T
Q
H
K
N
I
-
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
-
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
--
F
D
Q
D
G
--
Y
Y
Y
P
-
D
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
F
RD
F
N
D
P
-
S
Q
-
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
Q
G
F
K
G
F
Q
V
A
P
E
H
H
N
D
H
K
T
F
-
I
Y
D
N
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
-
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
P
--
L
-
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
--
V
H
P
-
N
T
R
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
A
L
A
T
P
-
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
-
G
T
F
A
N
I
R
L
L
N
R
F
L
-
N
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
I
-
P
E
N
L
K
P
Q
M
K
V
Q
V
K
L
--
D
T
G
K
--
T
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
K
M
A
K
--
26
HHSearch
85.23
53%
-21
- C3 -
2B3Y
4
ACOC_HUMAN
A:
[7-887]
--------------
L
A
E
P
L
D
P
V
Q
P
G
K
K
F
F
N
L
N
-
K
L
E
D
---
S
R
Y
G
R
L
P
F
S
I
R
V
L
L
E
A
A
I
R
N
C
D
E
F
L
V
K
K
Q
D
I
E
N
I
L
H
W
N
V
T
Q
H
K
N
I
-
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
V
C
P
A
D
L
V
I
D
H
S
I
Q
V
D
F
N
R
R
A
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
E
F
L
K
-
W
G
S
Q
A
F
H
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
F
D
Q
----
D
G
Y
Y
Y
P
-
D
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
D
E
V
S
I
T
Y
L
V
Q
T
G
R
D
E
E
K
L
K
Y
I
K
K
Y
L
Q
A
V
G
M
F
--
R
D
F
N
D
P
S
Q
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
Q
G
F
K
G
F
Q
V
A
P
E
H
H
N
D
H
K
T
F
I
Y
-
D
N
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
-
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
M
P
Y
I
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
S
G
P
--
L
-
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
--
V
H
P
-
N
T
R
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
V
N
A
K
G
Q
Q
V
F
L
K
D
I
W
P
T
R
D
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
K
E
V
Y
Q
K
I
E
T
V
N
E
S
W
N
A
L
A
T
P
-
S
D
K
L
F
F
W
N
S
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
V
M
A
R
-
G
T
F
A
N
I
R
L
L
N
R
F
L
N
-
K
Q
A
P
Q
T
I
H
L
P
S
G
E
I
L
D
V
F
D
A
A
E
R
Y
Q
Q
A
G
L
P
L
I
V
L
A
G
K
E
Y
G
A
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
A
L
G
L
T
G
Q
E
R
Y
T
I
I
I
P
E
N
-
L
K
P
Q
M
K
V
Q
V
K
L
-
D
T
G
---
K
T
F
Q
A
V
M
R
F
D
T
D
V
E
L
T
Y
F
L
N
G
G
I
L
N
Y
M
I
R
K
M
A
---
3
PsiBlast_PDB
80.36
53%
-32
- C3 -
3SNP
-
ACOC_RABIT
A:
[21-889]
---------------------------
F
F
N
L
N
-
K
L
D
Y
S
R
Y
G
R
---
L
P
F
S
I
R
V
L
L
E
A
A
V
R
N
C
D
K
F
L
V
K
K
E
D
I
E
N
I
L
N
W
N
V
T
Q
H
M
N
I
-
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
S
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
I
C
P
V
D
L
V
I
D
H
S
------------------
E
F
E
R
N
R
E
R
F
E
F
L
K
-
W
G
S
K
A
F
R
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
--
F
D
Q
D
G
--
Y
Y
Y
P
-
D
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
V
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
T
F
F
P
V
D
E
V
S
I
K
Y
L
V
Q
T
G
R
D
E
S
K
V
K
Q
I
R
K
Y
L
Q
A
V
G
M
F
RD
Y
S
D
P
-
S
Q
-
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
Q
G
F
K
G
F
Q
V
A
P
D
H
H
N
D
H
K
T
F
-
I
Y
N
D
S
E
F
T
L
S
H
G
S
V
V
I
A
A
I
T
S
S
T
N
T
S
N
P
S
V
M
L
G
-
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
K
P
Y
V
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
R
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
------------
P
--
L
-
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
--
V
H
P
-
N
T
R
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
T
N
A
K
G
Q
Q
V
F
L
R
D
I
W
P
T
R
E
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
T
E
V
Y
Q
K
I
E
T
V
N
A
S
W
---------
K
L
Y
L
W
N
P
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
I
M
A
R
-
G
T
F
A
N
I
R
L
L
N
R
F
L
-
N
K
Q
A
P
Q
T
I
H
L
P
S
G
E
T
L
D
V
F
D
A
A
E
R
Y
Q
Q
E
G
H
P
L
I
V
L
A
G
K
E
Y
G
S
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
S
L
G
L
T
G
R
E
R
Y
T
I
I
I
-
P
E
N
L
T
P
R
M
H
V
Q
V
K
L
--
D
T
G
K
--
T
F
Q
A
V
I
R
F
D
T
D
V
E
L
T
Y
F
H
N
G
G
I
L
N
Y
M
I
R
K
M
A
K
--
4
PsiBlast_PDB
80.01
53%
-30
- C3 -
3SN2
-
ACOC_RABIT
A:
[21-889]
---------------------------
F
F
N
L
N
-
K
L
D
Y
S
R
Y
G
R
---
L
P
F
S
I
R
V
L
L
E
A
A
V
R
N
C
D
K
F
L
V
K
K
E
D
I
E
N
I
L
N
W
N
V
T
Q
H
M
N
I
-
E
V
P
F
K
P
A
R
V
I
L
Q
D
F
T
G
V
P
S
V
V
D
F
A
A
M
R
D
A
V
K
K
L
G
G
D
P
E
K
I
N
P
I
C
P
V
D
L
V
I
D
---------------------
F
E
R
N
R
E
R
F
E
F
L
K
-
W
G
S
K
A
F
R
N
M
R
I
I
P
P
G
S
G
I
I
H
Q
V
N
L
E
Y
L
A
R
V
V
--
F
D
Q
D
G
--
Y
Y
Y
P
-
D
S
L
-
V
G
T
D
S
H
T
T
M
I
D
G
L
G
V
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
T
K
H
L
R
Q
V
G
V
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
T
F
F
P
V
D
E
V
S
I
K
Y
L
V
Q
T
G
R
D
E
S
K
V
K
Q
I
R
K
Y
L
Q
A
V
G
M
F
RD
Y
S
D
P
-
S
Q
-
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
V
P
C
C
S
G
P
K
R
P
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
A
K
Q
G
F
K
G
F
Q
V
A
P
D
H
H
N
D
H
K
T
F
-
I
Y
N
D
S
E
F
T
L
S
H
G
S
V
V
I
A
A
I
T
S
S
T
N
T
S
N
P
S
V
M
L
G
-
A
G
L
L
A
K
K
A
V
D
A
G
L
N
V
K
P
Y
V
K
T
S
L
S
P
G
S
G
V
V
T
Y
Y
L
R
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
------------
P
--
L
-
P
E
P
V
V
E
A
I
T
Q
G
D
L
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
--
V
H
P
-
N
T
R
A
N
Y
L
A
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
R
I
D
F
E
K
E
P
L
G
T
N
A
K
G
Q
Q
V
F
L
R
D
I
W
P
T
R
E
E
I
Q
A
V
E
R
Q
Y
V
I
P
G
M
F
T
E
V
Y
Q
K
I
E
T
V
N
A
S
--------
S
D
K
L
Y
L
W
N
P
K
S
T
Y
I
K
S
P
P
F
F
E
N
L
T
L
D
L
Q
P
P
K
S
I
V
D
A
Y
V
L
L
N
L
G
D
S
V
T
T
D
H
I
S
P
A
G
N
I
A
R
N
S
P
A
A
R
Y
L
T
N
R
G
L
T
P
R
E
F
N
S
Y
G
S
R
R
G
N
D
A
I
M
A
R
-
G
T
F
A
N
I
R
L
L
N
R
F
L
-
N
K
Q
A
P
Q
T
I
H
L
P
S
G
E
T
L
D
V
F
D
A
A
E
R
Y
Q
Q
E
G
H
P
L
I
V
L
A
G
K
E
Y
G
S
G
S
S
R
D
W
A
A
K
G
P
F
L
L
G
I
K
A
V
L
A
E
S
Y
E
R
I
H
R
S
N
L
V
G
M
G
V
I
P
L
E
Y
L
P
G
E
N
A
D
S
L
G
L
T
G
R
E
R
Y
T
I
I
I
-
P
E
N
L
T
P
R
M
H
V
Q
V
K
L
--
D
T
G
K
--
T
F
Q
A
V
I
R
F
D
T
D
V
E
L
T
Y
F
H
N
G
G
I
L
N
Y
M
I
R
K
M
A
K
--
27
HHSearch
54.69
29%
6
* C3 *
1C96
3
ACON_BOVIN
A:
[13-752]
-----------------------
E
Y
I
R
Y
D
L
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
T
L
S
E
K
I
V
Y
G
H
L
D
D
P
A
N
------
Q
E
I
E
----------
R
G
K
T
Y
L
R
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
-------
G
L
-
P
K
V
A
---
V
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
-----
E
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
A
--
K
Y
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
--------------
A
Y
P
G
V
L
L
-
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
A
D
I
-
A
N
L
A
D
E
F
K
--
D
H
L
V
--
P
D
P
-----
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
E
V
G
S
V
A
E
--------------------------------
K
E
G
W
P
L
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
-
A
-
A
V
A
K
Q
A
L
A
H
G
L
K
C
--
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W
D
R
KD
I
K
K
G
E
K
N
----------
T
I
V
T
S
Y
N
R
N
F
T
G
R
--
N
D
A
N
P
E
T
H
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
T
G
-
K
D
G
K
K
F
--
K
L
E
A
P
D
A
D
E
L
P
R
A
E
F
---
D
------------
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
S
G
Q
R
V
A
V
S
P
T
S
Q
R
L
Q
L
L
E
P
F
D
K
W
-----
D
G
K
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
F
--------------
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
I
N
I
E
N
R
K
A
-----
N
S
V
R
N
A
V
T
Q
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
--
I
H
P
V
D
K
L
T
I
Q
G
L
K
D
-
F
A
P
G
K
P
L
K
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
-
T
F
N
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
---
14
PsiBlast_PDB
54.23
27%
15
- C3 -
1FGH
2
ACON_BOVIN
A:
[64-754]
-----------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
L
P
K
V
A
V
-----------
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
-
L
R
R
A
K
D
I
----
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
--------------
Y
P
-
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
K
D
----
H
--
L
V
P
D
-
S
--
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
--------
E
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----------
Q
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
-
E
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
--
F
K
L
E
A
P
D
A
D
E
------------
L
P
R
A
E
----
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
-
D
S
S
G
Q
R
V
D
V
S
P
T
S
-
Q
R
L
Q
L
L
E
P
F
D
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
--------------
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
G
L
K
-
D
--
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
-
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
K
--
13
PsiBlast_PDB
53.91
27%
14
- C3 -
1ACO
2
ACON_BOVIN
A:
[64-754]
-----------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
L
P
K
V
A
V
-----------
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
-
L
R
R
A
K
D
I
----
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
--------------
Y
P
-
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
K
D
----
H
--
L
V
P
D
-
S
--
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
--------
E
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----------
Q
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
-
E
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
--
F
K
L
E
A
P
D
A
D
E
------------
L
P
R
A
E
----
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
-
D
S
S
G
Q
R
V
D
V
S
P
T
S
-
Q
R
L
Q
L
L
E
P
F
D
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
--------------
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
G
L
K
-
D
--
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
-
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
K
--
15
PsiBlast_PDB
53.74
27%
16
- C3 -
8ACN
2
ACON_BOVIN
A:
[64-754]
-----------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
L
P
K
V
A
V
-----------
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
-
L
R
R
A
K
D
I
----
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
--------------
Y
P
-
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
K
D
----
H
--
L
V
P
D
-
S
--
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
--------
E
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----------
Q
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
-
E
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
--
F
K
L
E
A
P
D
A
D
E
------------
L
P
R
A
E
----
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
-
D
S
S
G
Q
R
V
D
V
S
P
T
S
-
Q
R
L
Q
L
L
E
P
F
D
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
--------------
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
G
L
K
-
D
--
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
-
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
K
--
18
PsiBlast_PDB
53.60
27%
14
- C3 -
1NIT
2
ACON_BOVIN
A:
[64-754]
-----------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
L
P
K
V
A
V
-----------
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
-
L
R
R
A
K
D
I
----
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
--------------
Y
P
-
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
K
D
----
H
--
L
V
P
D
-
S
--
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
--------
E
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----------
Q
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
-
E
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
--
F
K
L
E
A
P
D
A
D
E
------------
L
P
R
A
E
----
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
-
D
S
S
G
Q
R
V
D
V
S
P
T
S
-
Q
R
L
Q
L
L
E
P
F
D
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
--------------
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
R
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
G
L
K
-
D
--
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
-
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
K
--
12
PsiBlast_PDB
53.51
27%
12
- C3 -
1AMJ
3
ACON_BOVIN
A:
[64-754]
-----------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
L
P
K
V
A
V
-----------
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
-
L
R
R
A
K
D
I
----
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
--------------
Y
P
-
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
K
D
----
H
--
L
V
P
D
-
S
--
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
--------
E
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----------
Q
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
-
E
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
--
F
K
L
E
A
P
D
A
D
E
------------
L
P
R
A
E
----
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
-
D
S
S
G
Q
R
V
D
V
S
P
T
S
-
Q
R
L
Q
L
L
E
P
F
D
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
--------------
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
G
L
K
-
D
--
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
-
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
K
--
11
PsiBlast_PDB
53.47
27%
16
- C3 -
1AMI
2
ACON_BOVIN
A:
[64-754]
-----------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
L
P
K
V
A
V
-----------
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
-
L
R
R
A
K
D
I
----
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
--------------
Y
P
-
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
K
D
----
H
--
L
V
P
D
-
S
--
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
--------
E
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----------
Q
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
-
E
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
--
F
K
L
E
A
P
D
A
D
E
------------
L
P
R
A
E
----
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
-
D
S
S
G
Q
R
V
D
V
S
P
T
S
-
Q
R
L
Q
L
L
E
P
F
D
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
--------------
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
G
L
K
-
D
--
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
-
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
K
--
17
PsiBlast_PDB
53.10
27%
14
- C3 -
1NIS
2
ACON_BOVIN
A:
[64-754]
-----------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
L
P
K
V
A
V
-----------
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
-
L
R
R
A
K
D
I
----
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
--------------
Y
P
-
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
K
D
----
H
--
L
V
P
D
-
S
--
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
--------
E
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----------
Q
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
-
E
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
--
F
K
L
E
A
P
D
A
D
E
------------
L
P
R
A
E
----
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
-
D
S
S
G
Q
R
V
D
V
S
P
T
S
-
Q
R
L
Q
L
L
E
P
F
D
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
--------------
L
I
G
A
I
N
S
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
R
A
L
E
P
R
F
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
K
L
T
I
Q
G
L
K
-
D
--
F
A
P
G
K
P
L
T
C
I
I
K
H
P
N
G
T
Q
E
T
I
L
L
N
H
T
F
N
-
E
T
Q
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
L
Q
Q
K
--
7
PsiBlast_PDB
51.09
29%
10
- C3 -
7ACN
2
ACON_PIG
A:
[64-682]
-----------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
L
P
K
V
A
V
-----------
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
-
L
R
R
A
K
D
I
----
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
--------------
Y
P
-
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
--
K
D
H
L
V
--
P
D
P
G
-
C
----
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
--------
E
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----------
Q
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
-
E
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
--
F
K
L
E
A
P
D
A
D
E
------------
L
P
R
A
E
----
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
-
D
S
S
G
Q
R
V
D
V
S
P
T
S
-
Q
R
L
Q
L
L
E
P
F
D
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
--------------
L
I
G
A
I
N
I
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
------------------------------------------------------------------------------
9
PsiBlast_PDB
51.06
28%
8
- C3 -
1C97
3
ACON_BOVIN
A:
[63-681]
-----------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
L
P
K
V
A
V
-----------
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
-
L
R
R
A
K
D
I
----
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
--------------
Y
P
-
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
--
K
D
H
L
V
--
P
D
P
G
-
C
----
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
--------
E
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----------
Q
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
-
E
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
--
F
K
L
E
A
P
D
A
D
E
------------
L
P
R
A
E
----
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
-
D
S
S
G
Q
R
V
D
V
S
P
T
S
-
Q
R
L
Q
L
L
E
P
F
D
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
--------------
L
I
G
A
I
N
I
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
------------------------------------------------------------------------------
5
PsiBlast_PDB
51.03
29%
8
- C3 -
5ACN
3
ACON_PIG
A:
[64-682]
-----------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
L
P
K
V
A
V
-----------
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
-
L
R
R
A
K
D
I
----
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
--------------
Y
P
-
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
--
K
D
H
L
V
--
P
D
P
G
-
C
----
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
--------
E
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----------
Q
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
-
E
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
--
F
K
L
E
A
P
D
A
D
E
------------
L
P
R
A
E
----
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
-
D
S
S
G
Q
R
V
D
V
S
P
T
S
-
Q
R
L
Q
L
L
E
P
F
D
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
--------------
L
I
G
A
I
N
I
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
------------------------------------------------------------------------------
6
PsiBlast_PDB
50.97
29%
9
- C3 -
6ACN
3
ACON_PIG
A:
[64-682]
-----------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
L
P
K
V
A
V
-----------
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
-
L
R
R
A
K
D
I
----
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
--------------
Y
P
-
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
--
K
D
H
L
V
--
P
D
P
G
-
C
----
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
--------
E
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----------
Q
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
-
E
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
--
F
K
L
E
A
P
D
A
D
E
------------
L
P
R
A
E
----
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
-
D
S
S
G
Q
R
V
D
V
S
P
T
S
-
Q
R
L
Q
L
L
E
P
F
D
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
--------------
L
I
G
A
I
N
I
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
------------------------------------------------------------------------------
8
PsiBlast_PDB
50.10
28%
12
- C3 -
1B0J
2
ACON_PIG
A:
[64-682]
-----------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
L
P
K
V
A
V
-----------
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
-
L
R
R
A
K
D
I
----
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
--------------
Y
P
-
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
--
K
D
H
L
V
--
P
D
P
G
-
C
----
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
--------
E
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----------
Q
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
-
E
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
--
F
K
L
E
A
P
D
A
D
E
------------
L
P
R
A
E
----
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
-
D
S
S
G
Q
R
V
D
V
S
P
T
S
-
Q
R
L
Q
L
L
E
P
F
D
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
--------------
L
I
G
A
I
N
I
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
A
S
R
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
------------------------------------------------------------------------------
16
PsiBlast_PDB
49.52
28%
10
- C3 -
1B0M
2
ACON_PIG
A:
[63-681]
-----------------------------------------------------------------------------------------
L
R
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G
L
P
K
V
A
V
-----------
P
S
T
I
H
C
D
H
L
I
E
A
Q
L
G
G
E
K
D
-
L
R
R
A
K
D
I
----
N
Q
E
V
Y
N
F
L
A
-
T
A
G
A
K
Y
G
-
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
N
Y
A
--------------
Y
P
-
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
A
G
I
L
T
V
K
G
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
-
A
D
I
A
N
L
A
D
E
F
--
K
D
H
L
V
--
P
D
P
G
-
C
----
H
Y
D
Q
V
I
E
I
N
L
S
E
L
K
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
A
--------
E
V
G
S
V
A
E
K
E
G
W
P
L
D
------------------------
I
R
V
G
L
I
G
S
C
T
N
S
S
--
Y
E
D
M
G
R
S
A
A
V
A
K
Q
A
L
A
H
G
L
K
C
K
S
--
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
----------
Q
W
D
R
K
D
I
K
K
G
E
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
ND
A
N
P
-
E
T
H
A
-
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
K
F
N
P
E
T
D
F
L
-
T
G
K
D
G
K
K
--
F
K
L
E
A
P
D
A
D
E
------------
L
P
R
A
E
----
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
-
D
S
S
G
Q
R
V
D
V
S
P
T
S
-
Q
R
L
Q
L
L
E
P
F
D
K
W
D
G
K
--
D
L
E
D
L
Q
I
L
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
P
---------
W
L
K
F
R
G
H
L
D
N
I
S
N
N
L
--------------
L
I
G
A
I
N
I
E
N
R
K
A
N
S
V
R
N
A
V
T
Q
-----
E
F
G
P
V
P
D
T
A
R
Y
Y
K
Q
H
G
I
R
W
V
V
I
G
D
E
N
Y
G
E
G
S
S
Q
E
H
S
A
L
E
P
R
H
L
G
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
N
L
K
K
Q
G
L
L
P
L
T
F
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