@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu18220: (2016-06-29 )
MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIEFNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIAAINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKEFIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGLETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70........80......-..90.......---.100.......110.......120.......130.......140.......150.......160.......170.......180.....----.-.190.......200.......210--........220.......230.....-------..240.......250.......260
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGD
S
I
L
F
T
VKNE
H
M
A
L
I
T
LNRPQAA
N
A
L
S
A
E
M
L
R
N
L
Q
M
I
I
Q
E
I
EFNSN
I
R
C
V
I
L
TGTGEKAFCAGA
D
L
K
E
R
I
KL
K
E
D
Q
V
L
E
S
V
S
L
I
Q
-
R
T
A
A
L
L
D
ALP
Q
---
P
V
I
A
AINGSALGGG
L
E
L
A
L
A
CD
L
R
I
AT
E
A
AVLGLPETG
L
A
I
IPGAG
G
T
Q
R
L
P
R
L
IGRGK
A
K
E
F
I
YTGRRV
T
A
H
E
A
K
EIG
L
V
EHVTAPCD----L-MP
K
A
E
E
L
A
A
A
ISANG
P
I
A
V
R
Q
A
K
---
F
A
INKGLE
T
D
L
ATG
L
A
I
E
Q
K
A
Y
EQTI-------P
T
K
D
R
R
E
G
L
Q
A
F
Q
E
K
R
R
A
V
YKGI
111
HHSearch
89.10
62%
-94
- C2 -
3KQF
1
?
A:
[10-264]
----
I
S
V
D
Y
A
T
P
H
V
V
K
I
S
L
N
R
E
R
Q
A
N
S
L
S
L
A
L
L
E
E
L
Q
N
I
L
T
Q
I
N
E
E
A
N
T
R
V
V
I
L
T
G
A
G
E
K
A
F
C
A
G
A
D
L
K
E
R
A
G
M
N
E
E
Q
V
R
H
A
V
S
M
I
R
-
T
T
M
E
M
V
E
Q
L
P
Q
---
P
V
I
A
A
I
N
G
I
A
L
G
G
G
T
E
L
S
L
A
C
D
F
R
I
A
A
E
S
A
S
L
G
L
T
E
T
T
L
A
I
I
P
G
A
G
G
T
Q
R
L
P
R
L
I
G
V
G
R
A
K
E
L
I
Y
T
G
R
R
I
S
A
Q
E
A
K
E
Y
G
L
V
E
F
V
V
P
V
H
L
----
L
-
E
E
K
A
I
E
I
A
E
K
I
A
S
N
G
P
I
A
V
R
L
A
K
---
E
A
I
S
N
G
I
Q
V
D
L
H
T
G
L
Q
M
E
K
Q
A
Y
E
G
V
I
-------
H
T
K
D
R
L
E
G
L
Q
A
F
K
E
K
R
T
P
M
Y
K
G
-
1
PsiBlast_PDB
87.78
63%
-90
- C2 -
3KQF
1
?
A:
[18-264]
------------
H
V
V
K
I
S
L
N
R
E
R
Q
A
N
S
L
S
L
A
L
L
E
E
L
Q
N
I
L
T
Q
I
N
E
E
A
N
T
R
V
V
I
L
T
G
A
G
E
K
A
F
C
A
G
A
D
L
K
E
R
A
G
M
N
E
E
Q
V
R
H
A
V
S
M
I
R
-
T
T
M
E
M
V
E
Q
L
P
Q
---
P
V
I
A
A
I
N
G
I
A
L
G
G
G
T
E
L
S
L
A
C
D
F
R
I
A
A
E
S
A
S
L
G
L
T
E
T
T
L
A
I
I
P
G
A
G
G
T
Q
R
L
P
R
L
I
G
V
G
R
A
K
E
L
I
Y
T
G
R
R
I
S
A
Q
E
A
K
E
Y
G
L
V
E
F
V
V
P
V
H
L
----
L
-
E
E
K
A
I
E
I
A
E
K
I
A
S
N
G
P
I
A
V
R
L
A
K
---
E
A
I
S
N
G
I
Q
V
D
L
H
T
G
L
Q
M
E
K
Q
A
Y
E
G
V
I
-------
H
T
K
D
R
L
E
G
L
Q
A
F
K
E
K
R
T
P
M
Y
K
G
-
4
PsiBlast_PDB
85.14
48%
-86
- C2 -
2ZQR
-
AUHM_HUMAN
A:
[85-338]
---------
E
N
R
G
I
V
V
L
G
I
N
R
A
Y
G
K
N
S
L
S
K
N
L
I
K
M
L
S
K
A
V
D
A
L
K
S
D
K
K
V
R
T
I
I
I
R
S
E
V
P
G
I
F
C
A
G
A
D
L
K
E
R
A
K
M
S
S
S
E
V
G
P
F
V
S
K
I
R
-
A
V
I
N
D
I
A
N
L
P
V
---
P
T
I
A
A
I
D
G
L
A
L
G
G
G
L
E
L
A
L
A
C
D
I
R
V
A
A
S
S
A
K
M
G
L
V
E
T
K
L
A
I
I
P
G
G
G
G
T
Q
R
L
P
R
A
I
G
M
S
L
A
K
E
L
I
F
S
A
R
V
L
D
G
K
E
A
K
A
V
G
L
I
S
H
V
L
E
Q
N
Q
EGD
A
A
-
Y
R
K
A
L
D
L
A
R
E
F
L
P
Q
G
P
V
A
M
R
V
A
K
---
L
A
I
N
Q
G
M
E
V
D
L
V
T
G
L
A
I
E
E
A
C
Y
A
Q
T
I
-------
P
T
K
D
R
L
E
G
L
L
A
F
K
E
K
R
P
P
R
Y
K
G
-
3
PsiBlast_PDB
84.72
48%
-86
- C2 -
2ZQQ
-
AUHM_HUMAN
A:
[85-338]
---------
E
N
R
G
I
V
V
L
G
I
N
R
A
Y
G
K
N
S
L
S
K
N
L
I
K
M
L
S
K
A
V
D
A
L
K
S
D
K
K
V
R
T
I
I
I
R
S
E
V
P
G
I
F
C
A
G
A
D
L
K
E
R
A
K
M
S
S
S
E
V
G
P
F
V
S
K
I
R
-
A
V
I
N
D
I
A
N
L
P
V
---
P
T
I
A
A
I
D
G
L
A
L
G
G
G
L
E
L
A
L
A
C
D
I
R
V
A
A
S
S
A
K
M
G
L
V
E
T
K
L
A
I
I
P
G
G
G
G
T
Q
R
L
P
R
A
I
G
M
S
L
A
K
E
L
I
F
S
A
R
V
L
D
G
K
E
A
K
A
V
G
L
I
S
H
V
L
E
Q
N
Q
EGD
A
A
-
Y
R
K
A
L
D
L
A
R
E
F
L
P
Q
G
P
V
A
M
R
V
A
K
---
L
A
I
N
Q
G
M
E
V
D
L
V
T
G
L
A
I
E
E
A
C
Y
A
Q
T
I
-------
P
T
K
D
R
L
E
G
L
L
A
F
K
E
K
R
P
P
R
Y
K
G
-
2
PsiBlast_PDB
83.73
48%
-83
- C2 -
1HZD
-
AUHM_HUMAN
A:
[85-338]
---------
E
N
R
G
I
V
V
L
G
I
N
R
A
Y
G
K
N
S
L
S
K
N
L
I
K
M
L
S
K
A
V
D
A
L
K
S
D
K
K
V
R
T
I
I
I
R
S
E
V
P
G
I
F
C
A
G
A
D
L
K
E
R
A
K
M
S
S
S
E
V
G
P
F
V
S
K
I
R
-
A
V
I
N
D
I
A
N
L
P
V
---
P
T
I
A
A
I
D
G
L
A
L
G
G
G
L
E
L
A
L
A
C
D
I
R
V
A
A
S
S
A
K
M
G
L
V
E
T
K
L
A
I
I
P
G
G
G
G
T
Q
R
L
P
R
A
I
G
M
S
L
A
K
E
L
I
F
S
A
R
V
L
D
G
K
E
A
K
A
V
G
L
I
S
H
V
L
E
Q
N
Q
EGD
A
A
-
Y
R
K
A
L
D
L
A
R
E
F
L
P
Q
G
P
V
A
M
R
V
A
K
---
L
A
I
N
Q
G
M
E
V
D
L
V
T
G
L
A
I
E
E
A
C
Y
A
Q
T
I
-------
P
T
K
D
R
L
E
G
L
L
A
F
K
E
K
R
P
P
R
Y
K
G
-
103
HHSearch
78.84
30%
-119
- C2 -
3HIN
-
?
A:
[16-266]
--
S
T
L
V
V
D
-
T
V
G
P
V
L
T
I
G
L
N
R
P
K
K
R
N
A
L
N
D
G
L
M
A
A
L
K
D
C
L
T
D
I
P
--
D
Q
I
R
A
V
V
I
H
G
I
G
-
D
H
F
S
A
G
L
D
L
S
E
L
R
E
R
D
A
T
E
G
L
V
H
S
Q
T
W
H
-
R
V
F
D
K
I
Q
Y
C
R
V
---
P
V
I
A
A
L
K
G
A
V
I
G
G
G
L
E
L
A
C
A
A
H
I
R
V
A
E
A
S
A
Y
Y
A
L
P
E
G
S
R
G
I
F
V
G
G
G
G
S
V
R
L
P
R
L
I
G
V
A
R
M
A
D
M
M
L
T
G
R
V
Y
S
A
A
E
G
V
V
H
G
F
S
Q
Y
L
I
E
N
G
S
----
A
-
Y
D
K
A
L
E
L
G
N
R
V
A
Q
N
A
P
L
T
N
F
A
V
L
---
Q
A
L
P
M
I
A
E
A
N
P
Q
T
G
L
L
M
E
S
L
M
A
T
V
A
Q
-------
S
D
Q
E
A
K
T
R
I
R
A
F
L
D
H
K
T
A
K
V
---
51
PsiBlast_CBE
77.14
41%
-108
- C2 -
2HW5
3
ECHM_HUMAN
C:
[39-284]
---------
K
N
N
T
V
G
L
I
Q
L
N
R
P
K
A
L
N
A
L
C
D
G
L
I
D
E
L
N
Q
A
L
K
I
F
E
E
D
P
A
V
G
A
I
V
L
T
G
-
G
D
K
A
F
A
A
G
A
D
I
K
E
M
Q
N
L
S
F
Q
D
C
Y
S
S
K
F
L
---
K
H
W
D
H
L
T
Q
V
K
K
---
P
V
I
A
A
V
N
G
Y
A
F
G
G
G
C
E
L
A
M
M
C
D
I
I
Y
A
G
E
K
A
Q
F
A
Q
P
E
I
L
I
G
T
I
P
G
A
G
G
T
Q
R
L
T
R
A
V
G
K
S
L
A
M
E
M
V
L
T
G
D
R
I
S
A
Q
D
A
K
Q
A
G
L
V
S
K
I
C
P
V
E
T
----
L
-
V
E
E
A
I
Q
C
A
E
K
I
A
S
N
S
K
I
V
V
A
M
A
K
---
E
S
V
N
A
A
F
E
M
T
L
T
E
G
S
K
L
E
K
K
L
F
Y
S
T
F
-------
A
T
D
D
R
K
E
G
M
T
A
F
V
E
K
R
K
A
N
F
K
--
50
PsiBlast_CBE
76.82
41%
-106
- C2 -
2HW5
2
ECHM_HUMAN
D:
[39-284]
---------
K
N
N
T
V
G
L
I
Q
L
N
R
P
K
A
L
N
A
L
C
D
G
L
I
D
E
L
N
Q
A
L
K
I
F
E
E
D
P
A
V
G
A
I
V
L
T
G
-
G
D
K
A
F
A
A
G
A
D
I
K
E
M
Q
N
L
S
F
Q
D
C
Y
S
S
K
F
L
---
K
H
W
D
H
L
T
Q
V
K
K
---
P
V
I
A
A
V
N
G
Y
A
F
G
G
G
C
E
L
A
M
M
C
D
I
I
Y
A
G
E
K
A
Q
F
A
Q
P
E
I
L
I
G
T
I
P
G
A
G
G
T
Q
R
L
T
R
A
V
G
K
S
L
A
M
E
M
V
L
T
G
D
R
I
S
A
Q
D
A
K
Q
A
G
L
V
S
K
I
C
P
V
E
T
----
L
-
V
E
E
A
I
Q
C
A
E
K
I
A
S
N
S
K
I
V
V
A
M
A
K
---
E
S
V
N
A
A
F
E
M
T
L
T
E
G
S
K
L
E
K
K
L
F
Y
S
T
F
-------
A
T
D
D
R
K
E
G
M
T
A
F
V
E
K
R
K
A
N
F
K
--
15
PsiBlast_PDB
76.60
40%
-106
- C2 -
3H81
5
ECHA8_MYCTU
A:
[31-271]
---------
R
D
Q
R
V
G
I
I
T
L
N
R
P
Q
A
L
N
A
L
N
S
Q
V
M
N
E
V
T
S
A
A
T
E
L
D
D
D
P
D
I
G
A
I
I
I
T
G
S
A
-
K
A
F
A
A
G
A
D
I
K
E
M
A
D
L
T
F
A
D
A
F
T
A
D
F
F
A
---
T
W
G
K
L
A
A
V
R
T
---
P
T
I
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
V
L
I
A
A
D
T
A
K
F
G
Q
P
E
I
K
L
G
V
L
P
G
M
G
G
S
Q
R
L
T
R
A
I
G
K
A
K
A
M
D
L
I
L
T
G
R
T
M
D
A
A
E
A
E
R
S
G
L
V
S
R
V
V
P
A
D
D
----
L
-
L
T
E
A
R
A
T
A
T
T
I
S
Q
M
S
A
S
A
A
R
M
A
K
---
E
A
V
N
R
A
F
E
S
S
L
S
E
G
L
L
Y
E
R
R
L
F
H
S
A
F
-------
A
T
E
D
Q
S
E
G
M
A
A
F
I
E
K
R
-------
64
PsiBlast_CBE
76.04
40%
-113
- C2 -
3H81
4
ECHA8_MYCTU
B:
[31-271]
---------
R
D
Q
R
V
G
I
I
T
L
N
R
P
Q
A
L
N
A
L
N
S
Q
V
M
N
E
V
T
S
A
A
T
E
L
D
D
D
P
D
I
G
A
I
I
I
T
G
S
A
-
K
A
F
A
A
G
A
D
I
K
E
M
A
D
L
T
F
A
D
A
F
T
A
D
F
F
A
---
T
W
G
K
L
A
A
V
R
T
---
P
T
I
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
V
L
I
A
A
D
T
A
K
F
G
Q
P
E
I
K
L
G
V
L
P
G
M
G
G
S
Q
R
L
T
R
A
I
G
K
A
K
A
M
D
L
I
L
T
G
R
T
M
D
A
A
E
A
E
R
S
G
L
V
S
R
V
V
P
A
D
D
----
L
-
L
T
E
A
R
A
T
A
T
T
I
S
Q
M
S
A
S
A
A
R
M
A
K
---
E
A
V
N
R
A
F
E
S
S
L
S
E
G
L
L
Y
E
R
R
L
F
H
S
A
F
-------
A
T
E
D
Q
S
E
G
M
A
A
F
I
E
K
R
-------
57
PsiBlast_CBE
75.96
40%
-112
- C2 -
3Q0G
2
ECHA8_MYCTU
B:
[10-250]
---------
R
D
Q
R
V
G
I
I
T
L
N
R
P
Q
A
L
N
A
L
N
S
Q
V
M
N
E
V
T
S
A
A
T
E
L
D
D
D
P
D
I
G
A
I
I
I
T
G
S
A
-
K
A
F
A
A
G
A
D
I
K
E
M
A
D
L
T
F
A
D
A
F
T
A
D
F
F
A
---
T
W
G
K
L
A
A
V
R
T
---
P
T
I
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
V
L
I
A
A
D
T
A
K
F
G
Q
P
E
I
K
L
G
V
L
P
G
M
G
G
S
Q
R
L
T
R
A
I
G
K
A
K
A
M
D
L
I
L
T
G
R
T
M
D
A
A
E
A
E
R
S
G
L
V
S
R
V
V
P
A
D
D
----
L
-
L
T
E
A
R
A
T
A
T
T
I
S
Q
M
S
A
S
A
A
R
M
A
K
---
E
A
V
N
R
A
F
E
S
S
L
S
E
G
L
L
Y
E
R
R
L
F
H
S
A
F
-------
A
T
E
D
Q
S
E
G
M
A
A
F
I
E
K
R
-------
11
PsiBlast_PDB
75.37
41%
-104
- C2 -
2HW5
-
ECHM_HUMAN
A:
[39-284]
---------
K
N
N
T
V
G
L
I
Q
L
N
R
P
K
A
L
N
A
L
C
D
G
L
I
D
E
L
N
Q
A
L
K
I
F
E
E
D
P
A
V
G
A
I
V
L
T
G
-
G
D
K
A
F
A
A
G
A
D
I
K
E
M
Q
N
L
S
F
Q
D
C
Y
S
S
K
F
L
---
K
H
W
D
H
L
T
Q
V
K
K
---
P
V
I
A
A
V
N
G
Y
A
F
G
G
G
C
E
L
A
M
M
C
D
I
I
Y
A
G
E
K
A
Q
F
A
Q
P
E
I
L
I
G
T
I
P
G
A
G
G
T
Q
R
L
T
R
A
V
G
K
S
L
A
M
E
M
V
L
T
G
D
R
I
S
A
Q
D
A
K
Q
A
G
L
V
S
K
I
C
P
V
E
T
----
L
-
V
E
E
A
I
Q
C
A
E
K
I
A
S
N
S
K
I
V
V
A
M
A
K
---
E
S
V
N
A
A
F
E
M
T
L
T
E
G
S
K
L
E
K
K
L
F
Y
S
T
F
-------
A
T
D
D
R
K
E
G
M
T
A
F
V
E
K
R
K
A
N
F
K
--
56
PsiBlast_CBE
75.22
40%
-106
- C2 -
3Q0G
2
ECHA8_MYCTU
C:
[10-250]
---------
R
D
Q
R
V
G
I
I
T
L
N
R
P
Q
A
L
N
A
L
N
S
Q
V
M
N
E
V
T
S
A
A
T
E
L
D
D
D
P
D
I
G
A
I
I
I
T
G
S
A
-
K
A
F
A
A
G
A
D
I
K
E
M
A
D
L
T
F
A
D
A
F
T
A
D
F
F
A
---
T
W
G
K
L
A
A
V
R
T
---
P
T
I
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
V
L
I
A
A
D
T
A
K
F
G
Q
P
E
I
K
L
G
V
L
P
G
M
G
G
S
Q
R
L
T
R
A
I
G
K
A
K
A
M
D
L
I
L
T
G
R
T
M
D
A
A
E
A
E
R
S
G
L
V
S
R
V
V
P
A
D
D
----
L
-
L
T
E
A
R
A
T
A
T
T
I
S
Q
M
S
A
S
A
A
R
M
A
K
---
E
A
V
N
R
A
F
E
S
S
L
S
E
G
L
L
Y
E
R
R
L
F
H
S
A
F
-------
A
T
E
D
Q
S
E
G
M
A
A
F
I
E
K
R
-------
16
PsiBlast_PDB
75.16
40%
-104
- C- -
4FJW
-
ECHA8_MYCTU
D:
[10-250]
---------
R
D
Q
R
V
G
I
I
T
L
N
R
P
Q
A
L
N
A
L
N
S
Q
V
M
N
E
V
T
S
A
A
T
E
L
D
D
D
P
D
I
G
A
I
I
I
T
G
S
A
-
K
A
F
A
A
G
A
D
I
K
E
M
A
D
L
T
F
A
D
A
F
T
A
D
F
F
A
---
T
W
G
K
L
A
A
V
R
T
---
P
T
I
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
V
L
I
A
A
D
T
A
K
F
G
Q
P
Q
I
K
L
G
V
L
P
G
M
G
G
S
Q
R
L
T
R
A
I
G
K
A
K
A
M
D
L
I
L
T
G
R
T
M
D
A
A
E
A
E
R
S
G
L
V
S
R
V
V
P
A
D
D
----
L
-
L
T
E
A
R
A
T
A
T
T
I
S
Q
M
S
A
S
A
A
R
M
A
K
---
E
A
V
N
R
A
F
E
S
S
L
S
E
G
L
L
Y
E
R
R
L
F
H
S
A
F
-------
A
T
E
D
Q
S
E
G
M
A
A
F
I
E
K
R
-------
59
PsiBlast_CBE
74.94
40%
-104
- C2 -
3PZK
2
ECHA8_MYCTU
B:
[10-250]
---------
R
D
Q
R
V
G
I
I
T
L
N
R
P
Q
A
L
N
A
L
N
S
Q
V
M
N
E
V
T
S
A
A
T
E
L
D
D
D
P
D
I
G
A
I
I
I
T
G
S
A
-
K
A
F
A
A
G
A
D
I
K
E
M
A
D
L
T
F
A
D
A
F
T
A
D
F
F
A
---
T
W
G
K
L
A
A
V
R
T
---
P
T
I
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
V
L
I
A
A
D
T
A
K
F
G
Q
P
E
I
K
L
G
V
L
P
G
M
G
G
S
Q
R
L
T
R
A
I
G
K
A
K
A
M
D
L
I
L
T
G
R
T
M
D
A
A
E
A
E
R
S
G
L
V
S
R
V
V
P
A
D
D
----
L
-
L
T
E
A
R
A
T
A
T
T
I
S
Q
M
S
A
S
A
A
R
M
A
K
---
E
A
V
N
R
A
F
E
S
S
L
S
E
G
L
L
Y
E
R
R
L
F
H
S
A
F
-------
A
T
E
D
Q
S
E
G
M
A
A
F
I
E
K
R
-------
54
PsiBlast_CBE
74.94
40%
-113
- C2 -
3Q0G
1
ECHA8_MYCTU
E:
[10-250]
---------
R
D
Q
R
V
G
I
I
T
L
N
R
P
Q
A
L
N
A
L
N
S
Q
V
M
N
E
V
T
S
A
A
T
E
L
D
D
D
P
D
I
G
A
I
I
I
T
G
S
A
-
K
A
F
A
A
G
A
D
I
K
E
M
A
D
L
T
F
A
D
A
F
T
A
D
F
F
A
---
T
W
G
K
L
A
A
V
R
T
---
P
T
I
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
V
L
I
A
A
D
T
A
K
F
G
Q
P
E
I
K
L
G
V
L
P
G
M
G
G
S
Q
R
L
T
R
A
I
G
K
A
K
A
M
D
L
I
L
T
G
R
T
M
D
A
A
E
A
E
R
S
G
L
V
S
R
V
V
P
A
D
D
----
L
-
L
T
E
A
R
A
T
A
T
T
I
S
Q
M
S
A
S
A
A
R
M
A
K
---
E
A
V
N
R
A
F
E
S
S
L
S
E
G
L
L
Y
E
R
R
L
F
H
S
A
F
-------
A
T
E
D
Q
S
E
G
M
A
A
F
I
E
K
R
-------
52
PsiBlast_CBE
74.81
41%
-108
- C2 -
2HW5
2
ECHM_HUMAN
B:
[39-284]
---------
K
N
N
T
V
G
L
I
Q
L
N
R
P
K
A
L
N
A
L
C
D
G
L
I
D
E
L
N
Q
A
L
K
I
F
E
E
D
P
A
V
G
A
I
V
L
T
G
-
G
D
K
A
F
A
A
G
A
D
I
K
E
M
Q
N
L
S
F
Q
D
C
Y
S
S
K
F
L
---
K
H
W
D
H
L
T
Q
V
K
K
---
P
V
I
A
A
V
N
G
Y
A
F
G
G
G
C
E
L
A
M
M
C
D
I
I
Y
A
G
E
K
A
Q
F
A
Q
P
E
I
L
I
G
T
I
P
G
A
G
G
T
Q
R
L
T
R
A
V
G
K
S
L
A
M
E
M
V
L
T
G
D
R
I
S
A
Q
D
A
K
Q
A
G
L
V
S
K
I
C
P
V
E
T
----
L
-
V
E
E
A
I
Q
C
A
E
K
I
A
S
N
S
K
I
V
V
A
M
A
K
---
E
S
V
N
A
A
F
E
M
T
L
T
E
G
S
K
L
E
K
K
L
F
Y
S
T
F
-------
A
T
D
D
R
K
E
G
M
T
A
F
V
E
K
R
K
A
N
F
K
--
120
HHSearch
74.77
37%
-103
- C2 -
3MOY
6
?
A:
[10-262]
---
T
I
A
T
S
R
P
V
A
G
V
G
L
I
R
L
D
R
P
D
A
L
N
A
L
N
Q
T
L
E
A
E
V
L
D
A
A
R
D
F
D
A
D
L
E
I
G
A
I
V
V
T
G
S
E
-
R
A
F
A
A
G
A
D
I
A
E
M
V
T
L
T
P
H
Q
--
A
R
E
R
N
L
L
-
S
G
W
D
S
L
T
Q
V
R
K
---
P
I
V
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
L
C
D
L
V
I
A
A
D
T
A
R
F
G
Q
P
E
I
T
L
G
I
L
P
G
L
G
G
T
Q
R
L
T
R
A
V
G
K
A
K
A
M
D
L
C
L
T
G
R
S
L
T
A
E
E
A
E
R
V
G
L
V
S
R
I
V
P
A
A
D
----
L
-
L
D
E
A
L
A
V
A
Q
R
I
A
R
M
S
R
P
A
G
R
A
V
K
---
D
A
I
N
E
A
F
E
R
P
L
S
A
G
M
R
Y
E
R
D
A
F
Y
A
M
F
-------
D
T
H
D
Q
T
E
G
M
T
A
F
L
E
K
R
T
P
E
F
T
D
-
53
PsiBlast_CBE
74.77
40%
-106
- C2 -
3Q0G
1
ECHA8_MYCTU
F:
[10-250]
---------
R
D
Q
R
V
G
I
I
T
L
N
R
P
Q
A
L
N
A
L
N
S
Q
V
M
N
E
V
T
S
A
A
T
E
L
D
D
D
P
D
I
G
A
I
I
I
T
G
S
A
-
K
A
F
A
A
G
A
D
I
K
E
M
A
D
L
T
F
A
D
A
F
T
A
D
F
F
A
---
T
W
G
K
L
A
A
V
R
T
---
P
T
I
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
V
L
I
A
A
D
T
A
K
F
G
Q
P
E
I
K
L
G
V
L
P
G
M
G
G
S
Q
R
L
T
R
A
I
G
K
A
K
A
M
D
L
I
L
T
G
R
T
M
D
A
A
E
A
E
R
S
G
L
V
S
R
V
V
P
A
D
D
----
L
-
L
T
E
A
R
A
T
A
T
T
I
S
Q
M
S
A
S
A
A
R
M
A
K
---
E
A
V
N
R
A
F
E
S
S
L
S
E
G
L
L
Y
E
R
R
L
F
H
S
A
F
-------
A
T
E
D
Q
S
E
G
M
A
A
F
I
E
K
R
-------
58
PsiBlast_CBE
74.71
40%
-109
- C2 -
3PZK
1
ECHA8_MYCTU
C:
[10-250]
---------
R
D
Q
R
V
G
I
I
T
L
N
R
P
Q
A
L
N
A
L
N
S
Q
V
M
N
E
V
T
S
A
A
T
E
L
D
D
D
P
D
I
G
A
I
I
I
T
G
S
A
-
K
A
F
A
A
G
A
D
I
K
E
M
A
D
L
T
F
A
D
A
F
T
A
D
F
F
A
---
T
W
G
K
L
A
A
V
R
T
---
P
T
I
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
V
L
I
A
A
D
T
A
K
F
G
Q
P
E
I
K
L
G
V
L
P
G
M
G
G
S
Q
R
L
T
R
A
I
G
K
A
K
A
M
D
L
I
L
T
G
R
T
M
D
A
A
E
A
E
R
S
G
L
V
S
R
V
V
P
A
D
D
----
L
-
L
T
E
A
R
A
T
A
T
T
I
S
Q
M
S
A
S
A
A
R
M
A
K
---
E
A
V
N
R
A
F
E
S
S
L
S
E
G
L
L
Y
E
R
R
L
F
H
S
A
F
-------
A
T
E
D
Q
S
E
G
M
A
A
F
I
E
K
R
-------
63
PsiBlast_CBE
73.86
40%
-104
- C2 -
3H81
6
ECHA8_MYCTU
C:
[31-271]
---------
R
D
Q
R
V
G
I
I
T
L
N
R
P
Q
A
L
N
A
L
N
S
Q
V
M
N
E
V
T
S
A
A
T
E
L
D
D
D
P
D
I
G
A
I
I
I
T
G
S
A
-
K
A
F
A
A
G
A
D
I
K
E
M
A
D
L
T
F
A
D
A
F
T
A
D
F
F
A
---
T
W
G
K
L
A
A
V
R
T
---
P
T
I
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
M
C
D
V
L
I
A
A
D
T
A
K
F
G
Q
P
E
I
K
L
G
V
L
P
G
M
G
G
S
Q
R
L
T
R
A
I
G
K
A
K
A
M
D
L
I
L
T
G
R
T
M
D
A
A
E
A
E
R
S
G
L
V
S
R
V
V
P
A
D
D
----
L
-
L
T
E
A
R
A
T
A
T
T
I
S
Q
M
S
A
S
A
A
R
M
A
K
---
E
A
V
N
R
A
F
E
S
S
L
S
E
G
L
L
Y
E
R
R
L
F
H
S
A
F
-------
A
T
E
D
Q
S
E
G
M
A
A
F
I
E
K
R
-------
69
PsiBlast_CBE
71.94
35%
-95
- C2 -
3R0O
4
?
B:
[24-271]
------------
N
V
A
L
I
T
I
D
R
P
D
A
R
N
A
V
N
G
A
V
S
T
A
V
G
D
A
L
E
E
A
Q
R
D
P
E
V
W
A
V
V
I
T
G
A
G
D
K
S
F
C
A
G
A
D
L
K
A
-
I
S
R
G
E
N
L
Y
H
A
E
H
P
E
W
G
-
F
A
G
Y
V
H
H
F
I
D
K
---
P
T
I
A
A
V
N
G
T
A
L
G
G
G
S
E
L
A
L
A
S
D
L
V
I
A
C
E
S
A
S
F
G
L
P
E
V
K
R
G
L
I
A
G
A
G
G
V
F
R
I
V
E
Q
L
P
R
K
V
A
L
E
L
V
L
T
G
E
P
M
T
A
S
D
A
L
R
W
G
L
I
N
E
V
V
P
D
G
T
----
V
-
V
E
A
A
L
A
L
A
E
R
I
T
C
N
A
P
L
S
V
Q
A
S
K
R
V
A
Y
G
A
D
D
G
I
-------
I
G
A
E
E
P
K
W
E
R
T
I
R
E
F
T
E
L
L
K
S
E
D
A
K
E
G
P
L
A
F
A
E
K
R
Q
P
V
W
K
--
79
PsiBlast_CBE
68.80
34%
-86
- C2 -
3R9T
1
?
A:
[18-265]
------------
N
V
M
V
I
T
I
N
R
P
E
A
R
N
A
I
N
A
A
V
S
I
G
V
G
D
A
L
E
E
A
Q
H
D
P
E
V
R
A
V
V
L
T
G
A
G
D
K
S
F
C
A
G
A
D
L
K
A
-
I
A
R
R
E
N
L
Y
H
P
D
H
P
E
W
G
-
F
A
G
Y
V
R
H
F
I
D
K
---
P
T
I
A
A
V
N
G
T
A
L
G
G
G
T
E
L
A
L
A
S
D
L
V
V
A
D
E
R
A
Q
F
G
L
P
E
V
K
R
G
L
I
A
A
A
G
G
V
F
R
I
A
E
Q
L
P
R
K
V
A
M
R
L
L
L
T
G
E
P
L
S
A
A
A
A
R
D
W
G
L
I
N
E
V
V
E
A
G
S
----
V
-
L
D
A
A
L
A
L
A
S
A
I
T
V
N
A
P
L
S
V
Q
A
S
K
R
I
A
Y
G
V
D
D
G
V
V
V
G
D
E
P
G
W
D
R
T
M
R
E
M
R
A
L
L
-------
K
S
E
D
A
K
E
G
P
R
A
F
A
E
K
R
E
P
V
W
Q
--
77
PsiBlast_CBE
67.81
34%
-84
- C2 -
3R9T
1
?
C:
[18-265]
------------
N
V
M
V
I
T
I
N
R
P
E
A
R
N
A
I
N
A
A
V
S
I
G
V
G
D
A
L
E
E
A
Q
H
D
P
E
V
R
A
V
V
L
T
G
A
G
D
K
S
F
C
A
G
A
D
L
K
A
-
I
A
R
R
E
N
L
Y
H
P
D
H
P
E
W
G
-
F
A
G
Y
V
R
H
F
I
D
K
---
P
T
I
A
A
V
N
G
T
A
L
G
G
G
T
E
L
A
L
A
S
D
L
V
V
A
D
E
R
A
Q
F
G
L
P
E
V
K
R
G
L
I
A
A
A
G
G
V
F
R
I
A
E
Q
L
P
R
K
V
A
M
R
L
L
L
T
G
E
P
L
S
A
A
A
A
R
D
W
G
L
I
N
E
V
V
E
A
G
S
----
V
-
L
D
A
A
L
A
L
A
S
A
I
T
V
N
A
P
L
S
V
Q
A
S
K
RIA
Y
G
V
D
D
G
V
V
V
G
D
E
P
G
W
D
R
T
M
R
E
M
R
A
L
L
-------
K
S
E
D
A
K
E
G
P
R
--
A
E
K
R
E
P
V
W
Q
--
67
PsiBlast_CBE
66.00
39%
-45
- C2 -
4FZW
2
PAAF_ECOLI
B:
[5-257]
---
S
E
L
I
V
S
R
Q
Q
R
V
L
L
L
T
L
N
R
P
A
A
R
N
A
L
N
N
A
L
L
M
Q
L
V
N
E
L
E
A
A
A
T
D
T
S
I
S
V
C
V
I
T
G
N
A
-
R
F
F
A
A
G
A
D
L
N
E
---
M
A
E
K
D
L
A
A
T
L
N
D
T
R
P
Q
L
W
A
R
L
Q
A
F
N
K
---
P
L
I
A
A
V
N
G
Y
A
L
G
A
G
C
E
L
A
L
L
C
D
V
V
V
A
G
E
N
A
R
F
G
L
P
E
I
T
L
G
I
M
P
G
A
G
G
T
Q
R
L
I
R
S
V
G
K
S
L
A
S
K
M
V
L
S
G
E
S
I
T
A
Q
Q
A
Q
Q
A
G
L
V
S
D
V
F
-
P
S
D
----
L
T
L
E
Y
A
L
Q
L
A
S
K
M
A
R
H
S
P
L
A
L
Q
A
A
K
---
Q
A
L
R
Q
S
Q
E
V
A
L
Q
A
G
L
A
Q
E
R
Q
L
F
T
L
L
A
-------
A
T
E
D
R
H
E
G
I
S
A
F
L
Q
K
R
T
P
D
F
K
G
-
78
PsiBlast_CBE
65.78
34%
-85
- C2 -
3R9T
1
?
B:
[18-265]
------------
N
V
M
V
I
T
I
N
R
P
E
A
R
N
A
I
N
A
A
V
S
I
G
V
G
D
A
L
E
E
A
Q
H
D
P
E
V
R
A
V
V
L
T
G
A
G
D
K
S
F
C
A
G
A
D
L
K
A
-
I
A
R
R
E
N
L
Y
H
P
D
H
P
E
W
G
-
F
A
G
Y
V
R
H
F
I
D
K
---
P
T
I
A
A
V
N
G
T
A
L
G
G
G
T
E
L
A
L
A
S
D
L
V
V
A
D
E
R
A
Q
F
G
L
P
E
V
K
R
G
L
I
A
A
A
G
G
V
F
R
I
A
E
Q
L
P
R
K
V
A
M
R
L
L
L
T
G
E
P
L
S
A
A
A
A
R
D
W
G
L
I
N
E
V
V
E
A
G
S
----
V
-
L
D
A
A
L
A
L
A
S
A
I
T
V
N
A
P
L
S
V
Q
A
S
K
R
I
A
Y
G
V
D
D
G
V
V
V
G
D
E
P
G
W
D
R
T
M
R
E
M
R
A
L
L
-------
K
S
E
D
A
K
E
G
P
R
A
F
A
E
K
R
E
P
V
W
Q
--
20
PsiBlast_PDB
65.44
39%
-70
- C2 -
3MOY
5
?
A:
[20-256]
-------------
V
G
L
I
R
L
D
R
P
D
A
L
N
A
L
N
Q
T
L
E
A
E
V
L
D
A
A
R
D
F
D
A
D
L
E
I
G
A
I
V
V
T
G
S
-
E
R
A
F
A
A
G
A
D
I
A
E
M
V
T
L
T
P
H
Q
A
R
E
R
N
L
L
------
S
G
W
D
S
L
T
Q
VR
K
P
I
V
A
A
V
A
G
Y
A
L
G
G
G
C
E
L
A
M
L
C
D
L
V
I
A
A
D
T
A
R
F
G
Q
P
E
I
T
L
G
I
L
P
G
L
G
G
T
Q
R
L
T
R
A
V
G
K
A
K
A
M
D
L
C
L
T
G
R
S
L
T
A
E
E
A
E
R
V
G
L
V
S
R
I
V
P
A
A
D
----
L
-
L
D
E
A
L
A
V
A
Q
R
I
A
R
M
S
R
P
A
G
R
A
V
K
---
D
A
I
N
E
A
F
E
R
P
L
S
A
G
M
R
Y
E
R
D
A
F
Y
A
M
F
-------
D
T
H
D
Q
T
E
G
M
T
A
F
L
E
K
R
-------
80
PsiBlast_CBE
64.51
34%
-92
- C2 -
3R9S
3
?
C:
[18-265]
------------
N
V
M
V
I
T
I
N
R
P
E
A
R
N
A
V
N
A
A
V
S
I
G
V
G
D
A
L
E
E
A
Q
H
D
P
E
V
R
A
V
V
L
T
G
A
G
D
K
S
F
C
A
G
A
D
L
K
A
-
I
A
R
R
E
N
L
Y
H
P
D
H
P
E
W
G
-
F
A
G
Y
V
R
H
F
I
D
K
---
P
T
I
A
A
V
N
G
T
A
L
G
G
G
T
E
L
A
L
A
S
D
L
V
V
A
D
E
R
A
Q
F
G
L
P
E
V
K
R
G
L
I
A
A
A
G
G
V
F
R
I
A
E
Q
L
P
R
K
V
A
M
R
L
L
L
T
G
E
P
L
S
A
A
A
A
R
D
W
G
L
I
N
E
V
V
E
A
G
S
----
V
-
L
D
A
A
L
A
L
A
S
A
I
T
V
N
A
P
L
S
V
Q
A
S
K
RIA
Y
G
V
D
D
G
V
V
V
G
D
E
P
G
W
D
R
T
M
R
E
M
R
A
L
L
-------
K
S
E
D
A
K
E
G
P
R
A
F
----
E
P
V
W
Q
--
18
PsiBlast_PDB
64.00
39%
-45
- C2 -
4FZW
1
PAAF_ECOLI
A:
[5-257]
---
S
E
L
I
V
S
R
Q
Q
R
V
L
L
L
T
L
N
R
P
A
A
R
N
A
L
N
N
A
L
L
M
Q
L
V
N
E
L
E
A
A
A
T
D
T
S
I
S
V
C
V
I
T
G
N
A
-
R
F
F
A
A
G
A
D
L
N
E
---
M
A
E
K
D
L
A
A
T
L
N
D
T
R
P
Q
L
W
A
R
L
Q
A
F
N
K
---
P
L
I
A
A
V
N
G
Y
A
L
G
A
G
C
E
L
A
L
L
C
D
V
V
V
A
G
E
N
A
R
F
G
L
P
E
I
T
L
G
I
M
P
G
A
G
G
T
Q
R
L
I
R
S
V
G
K
S
L
A
S
K
M
V
L
S
G
E
S
I
T
A
Q
Q
A
Q
Q
A
G
L
V
S
D
V
F
-
P
S
D
----
L
T
L
E
Y
A
L
Q
L
A
S
K
M
A
R
H
S
P
L
A
L
Q
A
A
K
---
Q
A
L
R
Q
S
Q
E
V
A
L
Q
A
G
L
A
Q
E
R
Q
L
F
T
L
L
A
-------
A
T
E
D
R
H
E
G
I
S
A
F
L
Q
K
R
T
P
D
F
K
G
-
82
PsiBlast_CBE
62.18
34%
-90
- C2 -
3R9S
2
?
A:
[18-265]
------------
N
V
M
V
I
T
I
N
R
P
E
A
R
N
A
V
N
A
A
V
S
I
G
V
G
D
A
L
E
E
A
Q
H
D
P
E
V
R
A
V
V
L
T
G
A
G
D
K
S
F
C
A
G
A
D
L
K
A
-
I
A
R
R
E
N
L
Y
H
P
D
H
P
E
W
G
-
F
A
G
Y
V
R
H
F
I
D
K
---
P
T
I
A
A
V
N
G
T
A
L
G
G
G
T
E
L
A
L
A
S
D
L
V
V
A
D
E
R
A
Q
F
G
L
P
E
V
K
R
G
L
I
A
A
A
G
G
V
F
R
I
A
E
Q
L
P
R
K
V
A
M
R
L
L
L
T
G
E
P
L
S
A
A
A
A
R
D
W
G
L
I
N
E
V
V
E
A
G
S
----
V
-
L
D
A
A
L
A
L
A
S
A
I
T
V
N
A
P
L
S
V
Q
A
S
K
R
I
A
Y
G
V
D
D
G
V
V
V
G
D
E
P
G
W
D
R
T
M
R
E
M
R
A
L
L
-------
K
S
E
D
A
K
E
G
P
R
A
F
A
E
K
R
E
P
V
W
Q
--