@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu18230: (2016-06-29 )
MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSYIEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFMSASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVIRLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALANMVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSAAKWIEEKMGKPLPSRNLQVFKSS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPYP
K
K
V
T
I
K
EVGPRDGLQNE
P
V
W
I
ATED
K
I
T
W
I
N
Q
L
S
RTGL
S
Y
I
E
I
TSFVHP
K
W
I
P
A
L
R
D
A
I
D
V
A
KGIDREKG
V
T
Y
A
A
LVPNQR
G
L
E
N
A
L
EGGINE
A
C
V
F
M
SASETHNRKNINKS
T
S
E
S
L
H
I
L
K
Q
VNND
A
Q
K
AN
L
T
T
R
A
Y
L
S
T
V
FGCPYEKDV
P
I
E
Q
V
I
R
L
S
E
A
L
F
E
FG
I
S
ELSLGDTIGAA
N
P
A
Q
V
E
T
V
L
E
A
L
L
A
RFPA
N
Q
I
A
L
H
F
HDTR
G
T
A
L
A
N
M
V
T
A
L
QM
G
I
T
V
FDGSAGGLGGCPYAPGSSGN
A
A
T
E
D
I
V
Y
M
L
E
Q
MDIKTN
V
K
L
E
K
L
L
S
A
A
K
W
I
E
E
K
MGKPLPSR
N
L
Q
V
FKSS
42
HHSearch
91.41
100%
-82
- C1 -
1YDO
1
HMGCL_BACSU
A:
[1-298]
M
P
Y
P
K
K
V
T
I
K
E
V
G
P
R
D
G
L
Q
N
E
P
V
W
I
A
T
E
D
K
I
T
W
I
N
Q
L
S
R
T
G
L
S
Y
I
E
I
T
S
F
V
H
P
K
W
I
P
A
L
R
D
A
I
D
V
A
K
G
I
D
R
E
K
G
V
T
Y
A
A
L
V
P
N
Q
R
G
L
E
N
A
L
E
G
G
I
N
E
A
C
V
F
M
S
A
S
E
T
H
N
R
K
N
I
N
K
S
T
S
E
S
L
H
I
L
K
Q
V
N
N
D
A
Q
K
A
N
L
T
T
R
A
Y
L
S
T
V
F
G
C
P
Y
E
K
D
V
P
I
E
Q
V
I
R
L
S
E
A
L
F
E
F
G
I
S
E
L
S
L
G
D
T
I
G
A
A
N
P
A
Q
V
E
T
V
L
E
A
L
L
A
R
F
P
A
N
Q
I
A
L
H
F
H
D
T
R
G
T
A
L
A
N
M
V
T
A
L
Q
M
G
I
T
V
F
D
G
S
A
G
G
L
G
G
C
P
Y
A
P
G
S
S
G
N
A
A
T
E
D
I
V
Y
M
L
E
Q
M
D
I
K
T
N
V
K
L
E
K
L
L
S
A
A
K
W
I
E
E
K
M
G
K
P
L
P
S
R
N
L
Q
V
F
K
S
-
1
PsiBlast_PDB
90.59
97%
-82
- C1 -
1YDO
1
HMGCL_BACSU
A:
[2-298]
-
P
Y
P
K
K
V
T
I
K
E
V
G
P
R
D
G
L
Q
N
E
P
V
W
I
A
T
E
D
K
I
T
W
I
N
Q
L
S
R
T
G
L
S
Y
I
E
I
T
S
F
V
H
P
K
W
I
P
A
L
R
D
A
I
D
V
A
K
G
I
D
R
E
K
G
V
T
Y
A
A
L
V
P
N
Q
R
G
L
E
N
A
L
E
G
G
I
N
E
A
C
V
F
M
S
A
S
E
T
H
N
R
K
N
I
N
K
S
T
S
E
S
L
H
I
L
K
Q
V
N
N
D
A
Q
K
A
N
L
T
T
R
A
Y
L
S
T
V
F
G
C
P
Y
E
K
D
V
P
I
E
Q
V
I
R
L
S
E
A
L
F
E
F
G
I
S
E
L
S
L
G
D
T
I
G
A
A
N
P
A
Q
V
E
T
V
L
E
A
L
L
A
R
F
P
A
N
Q
I
A
L
H
F
H
D
T
R
G
T
A
L
A
N
M
V
T
A
L
Q
M
G
I
T
V
F
D
G
S
A
G
G
L
G
G
C
P
Y
A
P
G
S
S
G
N
A
A
T
E
D
I
V
Y
M
L
E
Q
M
D
I
K
T
N
V
K
L
E
K
L
L
S
A
A
K
W
I
E
E
K
M
G
K
P
L
P
S
R
N
L
Q
V
F
K
S
-
27
PsiBlast_CBE
79.39
46%
-95
- C1 -
2CW6
1
HMGCL_HUMAN
E:
[3-293]
---
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
-----
5
PsiBlast_PDB
77.53
46%
-94
- C1 -
3MP5
-
HMGCL_HUMAN
A:
[3-293]
---
P
K
R
V
K
I
V
E
V
G
P
M
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
-----
43
HHSearch
77.35
46%
-95
- C1 -
2CW6
2
HMGCL_HUMAN
A:
[1-293]
-
T
L
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
-----
2
PsiBlast_PDB
77.19
46%
-94
- C1 -
2CW6
2
HMGCL_HUMAN
A:
[3-293]
---
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
-----
32
PsiBlast_CBE
76.82
46%
-89
- C1 -
3MP5
2
HMGCL_HUMAN
B:
[3-293]
---
P
K
R
V
K
I
V
E
V
G
P
M
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
-----
30
PsiBlast_CBE
76.78
46%
-95
- C1 -
2CW6
1
HMGCL_HUMAN
B:
[3-293]
---
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
-----
4
PsiBlast_PDB
76.58
46%
-96
- C1 -
3MP4
-
HMGCL_HUMAN
A:
[30-320]
---
P
K
R
V
K
I
V
E
V
G
P
M
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
-----
3
PsiBlast_PDB
76.30
46%
-94
- C1 -
3MP3
2
HMGCL_HUMAN
A:
[3-293]
---
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
-----
21
PsiBlast_CBE
76.28
46%
-94
- C1 -
3MP3
1
HMGCL_HUMAN
F:
[3-293]
---
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
-----
22
PsiBlast_CBE
76.07
46%
-90
- C1 -
3MP3
1
HMGCL_HUMAN
E:
[3-293]
---
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
-----
31
PsiBlast_CBE
75.75
46%
-93
- C1 -
3MP5
1
HMGCL_HUMAN
C:
[3-293]
---
P
K
R
V
K
I
V
E
V
G
P
M
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
--------
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
-----
29
PsiBlast_CBE
75.72
46%
-93
- C1 -
2CW6
1
HMGCL_HUMAN
C:
[3-293]
---
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
-----
28
PsiBlast_CBE
75.43
46%
-96
- C1 -
2CW6
1
HMGCL_HUMAN
D:
[3-293]
---
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
-------
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
-------
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
-----
25
PsiBlast_CBE
75.22
46%
-88
- C1 -
3MP3
2
HMGCL_HUMAN
B:
[3-293]
---
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
-----
24
PsiBlast_CBE
75.06
46%
-93
- C1 -
3MP3
1
HMGCL_HUMAN
C:
[3-293]
---
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
G
C
P
Y
A
Q
G
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
-----
44
HHSearch
74.41
45%
-93
- C1 -
1YDN
1
?
A:
[2-284]
---
A
E
H
V
E
I
V
E
M
A
A
R
D
G
L
Q
N
E
K
R
F
V
P
T
A
D
K
I
A
L
I
N
R
L
S
D
C
G
Y
A
R
I
E
A
T
S
F
V
S
P
K
W
V
P
Q
L
A
D
S
R
E
V
M
A
G
I
R
R
A
D
G
V
R
Y
S
V
L
V
P
N
M
K
G
Y
E
A
A
A
A
A
H
A
D
E
I
A
V
F
I
S
A
S
E
G
F
S
K
A
N
I
N
C
T
I
A
E
S
I
E
R
L
S
P
V
I
G
A
A
I
N
D
G
L
A
I
R
G
Y
V
S
C
V
V
E
C
P
Y
D
G
P
V
T
P
Q
A
V
A
S
V
T
E
Q
L
F
S
L
G
C
H
E
V
S
L
G
D
T
I
G
R
G
T
P
D
T
V
A
A
M
L
D
A
V
L
A
I
A
P
A
H
S
L
A
G
H
Y
H
D
T
G
G
R
A
L
D
N
I
R
V
S
L
E
K
G
L
R
V
F
D
A
S
V
G
G
L
G
G
C
P
F
A
P
G
A
K
G
N
V
D
T
V
A
V
V
E
M
L
H
E
M
G
F
E
T
G
L
D
L
D
R
L
R
S
A
G
L
F
T
Q
A
L
R
Q
D
-------------
23
PsiBlast_CBE
74.22
46%
-94
- C1 -
3MP3
1
HMGCL_HUMAN
D:
[3-293]
---
P
K
R
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
S
E
A
G
L
S
V
I
E
T
T
S
F
V
S
P
K
W
V
P
Q
M
G
D
H
T
E
V
L
K
G
I
Q
K
F
P
G
I
N
Y
P
V
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
A
K
E
V
V
I
F
G
A
A
S
E
L
F
T
K
K
N
I
N
C
S
I
E
E
S
F
Q
R
F
D
A
I
L
K
A
A
Q
S
A
N
I
S
V
R
G
Y
V
S
C
A
L
G
C
P
Y
E
G
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
P
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
V
A
G
L
G
-------
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
A
L
N
R
K
T
S
S
K
V
A
Q
-----
41
HHSearch
73.90
46%
-88
- C1 -
2FTP
3
LIUE_PSEAE
A:
[3-294]
M
N
L
P
K
K
V
R
L
V
E
V
G
P
R
D
G
L
Q
N
E
K
Q
P
I
E
V
A
D
K
I
R
L
V
D
D
L
S
A
A
G
L
D
Y
I
E
V
G
S
F
V
S
P
K
W
V
P
Q
M
A
G
S
A
E
V
F
A
G
I
R
Q
R
P
G
V
T
Y
A
A
L
A
P
N
L
K
G
F
E
A
A
L
E
S
G
V
K
E
V
A
V
F
A
A
A
S
E
A
F
S
Q
R
N
I
N
C
S
I
K
D
S
L
E
R
F
V
P
V
L
E
A
A
R
Q
H
Q
V
R
V
R
G
Y
I
S
C
V
L
G
C
P
Y
D
G
D
V
D
P
R
Q
V
A
W
V
A
R
E
L
Q
Q
M
G
C
Y
E
V
S
L
G
D
T
I
G
V
G
T
A
G
A
T
R
R
L
I
E
A
V
A
S
E
V
P
R
E
R
L
A
G
H
F
H
D
T
Y
G
Q
A
L
A
N
I
Y
A
S
L
L
E
G
I
A
V
F
D
S
S
V
A
G
L
G
G
C
P
Y
A
K
G
A
T
G
N
V
A
S
E
D
V
L
Y
L
L
N
G
L
E
I
H
T
G
V
D
M
H
A
L
V
D
A
G
Q
R
I
C
A
V
L
G
K
S
N
G
S
R
A
-------