@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu18300: (2016-06-29 )
MKKGADTMNTIKKIKNIYPLSHMQEGMLFHSFLRKEEGAYVEQSLFTIKGSLSYDWFQRSIQAIIDRHDIFRTVFLPHVPHLSGPRQVVMTEREFHLNSEDISHLPTNDQNEYIERFKEKDKQKGFDLQKDMLMRISLFKTAKDEHVCIWSHHHILMDGWCLGIVMQEFMQIYQSIHAGKPLSLDPVRPYSTYISWLTNRDKEKAAAYWDTYLKNYSAPSPLPRVSDKETKESYHREDLIFSLNKPLTDKLKETAKQHGVTLATLIQAVWGVMLQQYNRTDDVVFGAVVSGRPSEIPGVEQMIGLFINTIPIRIKTHQDETFHELLIRCQKEMLEAEPFTCQPLFDIQANTALKQELIDHIIVFENYPLQQKIADSADQTDSPLQIDQVQVSEQSGYNFNLVVAPGEELVIKFSYNAFVYDAAWISCIKRQFTQALSTAAQHPHMPIADFSFLDATEKEQIVTQFNNTKTEYPKNHTIIDLFREQAEKTPDHTALVYGNMSISYKELDKRSNALARELIQKGFRKNETAGILAAHSPEFMISVLAVLKAGGAYLPLDAELPPERVSFMLEETQAKMLIVQKGLEQNAAFSGTCIISDAQGLMEENDIPINISSSPDDLAYIMYTSGSTGRPKGVMITNRNVVSLVRNSNYTSASGDDRFIMTGSISFDAVTFEMFGALLNGASLHIIDKSTMLTPDRFGAYLLENDITVLFLTTALFNQLAQVRADMFRGLHTLYVGGEALSPALMNAVRHACPDLALHNIYGPTENTTFSTFFEMKRDYAGPIPIGKPISNSTAYILDTKGRLLPIGVPGELCVGGDGVAKGYLNRVDLTNAVFSPHPFLPGERIYRTGDLARWLPDGNLEYISRIDRQMKIRGKRIEPAEIEARLLEMEGVQEAAVTLREKDGEAQLYTHYVGDHKKTDTDFRADLARVLPDYMIPQHWVRVERMPLTGNGKIDRSALPIPENKPAKRQNIILPRNLVEEELANIWKQVLGVNTISIDDDFFAIGGHSLRALQVIHTLKHQQNIDIPIDFLFEHPTIAQLAEKLYSKQLTAANEQHVIKLNQHGAQNLFCFPPISGFGIYFKDLALLLNEKAAVYGFHFIEQDTRIEQYVNCMTDIQPEGPYVLLGYSAGGNLAFEVAQAMERKGLEVSDFIIVDAYLKEQPLPIDTGNDESAAYLPEAVREKVMKKKRNYQEYWAQLLNEGHIKASIHFIEAGIHPETSGHTGLTKWEGACGNYSEYTGFGAHKDMLEGTYAEKNADIILDILEKITSNQVILHKR
Atome Classification :
(30 SA)
.........10........20........30........40........50...-.....60........70........80........90......-..100......-.110.......120.......-130---.......140.......150.......160.......170.......180.......190---........200-.----........210...----....220.......230.......240.......-250.....-..260.......270.......280.......290.......300.......310.......320.......330-...--------------......340.......350...-----....360.......370....-------...380.......390........400.--...--.---..410.......420.......430.......440.......450.......460.......---470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580...---...---.---590-.----.------------.......-----600.......-610.------..----....620.......630.......640.-.-..-..-.--650.....-..660.......670.......680.......690.......700.......710....----....720..-...-----..-..----730.......740-.....--.-.--750.....-..760.......------770..-----.-...-----.--780-.-...--....790........800....-.-...810-.........820.......830.......840-...--.....850.......860.......870.......880.......890....---...900.------.---.-.....910....--.--...--.920--.---......930.......940.......950.......960........970.......980.......990.......1000......1010......1020-......1030......1040......1050......1060....-...1070......1080......1090......1100....----------.---....1110-.........1120......1130......1140......1150......1160.....----------.---1170---.----.----.-------.....1180---.......---------------1190.-....-----.1200......1210.....---.1220......1230-.-.-....1240......1250......1260......1270......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKKG
A
D
T
M
N
T
I
K
K
I
K
NIY
P
L
S
H
M
Q
E
G
M
L
F
H
S
F
L
R
KEEGAY
V
E
Q
S
L
F
T
I
KGSL
S
Y
-
D
W
F
Q
R
S
I
Q
A
I
I
D
R
H
D
I
F
R
T
V
F
LPHVPHLSGP
R
Q
V
V
M
T
E
R
E
FHL-
N
S
E
D
I
SHLPTN-D
Q
N
E
Y
I
E
R
F
K
E
K
D
K
QKGF
D
L
Q
-
K
D
M
---
L
M
R
I
S
L
FKTAKDE
H
V
C
I
W
SH
H
H
I
L
MDG
W
C
L
G
I
V
M
Q
E
F
M
Q
I
Y
Q
S
IHAGKPLSLDPVR
P
Y
S
----
T
Y
I
S
W
L
TNR---
D
----
K
E
K
A
A
A
Y
W
D
T
Y
L
KN----YSAPSPLPRVS
D
K
E
T
K
E
S
Y
H
R
E
D
L
I
F
SLNK
P
L
T
D
-
K
L
K
E
T
A
K
Q-HG
V
T
L
A
T
L
I
Q
A
V
W
G
V
M
L
Q
QYNRTD
D
V
V
F
G
A
VVSGRPSEIP
G
V
E
Q
M
I
G
L
F
INT
I
P
I
R
I
K
THQD
E
T
F
H
E
L
L
I
R
C
Q
---
K
E
M
--------------LEAEPFTCQ
P
L
F
DIQA
N
T
A
L
K
Q
-----
E
L
I
D
H
I
I
V
FENY
P
L
Q
Q
K
I
ADS-------ADQTDSP
L
Q
I
D
Q
V
Q
-
V
SEQSG
Y
N
F
N
L
V
V--APG--E---
E
L
V
I
K
F
SYN
A
F
V
Y
D
A
A
W
I
S
C
I
K
R
Q
F
T
Q
A
L
S
T
A
AQHPHMPIADFSFLDA
T
E
K
E
Q
I
V
T
Q
FNNTK---TEYPKN
H
T
I
I
D
L
F
R
E
Q
A
EKTPD
H
T
A
L
V
Y
GN
M
S
I
S
Y
K
E
L
D
K
R
S
N
A
L
A
R
E
L
I
Q
K
GFRKNETA
G
I
LAAHS
P
E
F
M
I
S
V
L
A
V
L
KAGG
A
Y
LPLDAEL
P
P
E
R
V
S
F
M
L
E
E
TQ
A
K
M
L
I
V
Q
KGLEQ---NAA---F---S---
G
----
T
------------
C
I
ISD
A
Q
-----
G
LMEENDI
P
I
-NISS------SP----D
D
L
A
Y
I
M
YTSGSTGRP
K
G
V
M
I
TNR
N
V
V
S
-
L
-VR-NS-N--YTSASGD
D
-
R
F
I
M
TGSISF
D
A
V
T
F
E
M
F
G
A
L
LNG
A
S
L
H
I
IDKSTML
T
P
D
R
F
G
A
Y
L
L
END
I
T
V
L
-
F
L
T
T
A
----
L
F
N
Q
L
--
A
Q
-
V
R
A
-----
D
M
-
F
R
----
G
L
H
T
L
Y
VG
G
E
AL
S
-
P
A
L
M
N
--
A
-
V
--
R
H
ACP
D
L
A
-
L
H
NIYGPTENT
T
------
F
S
T
F
F
-----
E
-
M
K
R
-----D--YA--G-PIP--IGKPIS-NS
T
A
Y
I
LDTK-G
R
L
L
-
P
-IGVP---G
E
L
C
VGG
D
G
V
A
K
G
Y
LNRVDLTNAVFSPHPFL--PGE--
R
I
Y
RTG
D
L
A
RWLPDG
N
L
E
Y
I
S
R
I
D
R
Q
M
KIRGKRI
E
P
A
E
I
E
A
R
L
L
E
M
E
G
V
Q
E
A
---
A
V
T
L
-RE------K---D-GE
A
Q
L
Y
--
T
H
YV--G--DHK--KT
D
T
--
D
---
F
R
A
D
L
A
R
V
L
P
D
YMI
P
Q
H
W
V
R
V
E
RMPLTGNGKIDRSALP-IPENKPAKRQ
N
I
IL
P
R
N
L
V
E
E
E
L
A
N
I
W
K
Q
V
LG
V
N
T
I
S
IDD
D
F
F
AIGGH
S
L
R
A
L
Q
V
I
H
T
L
K
HQ-QNIDI
P
I
D
F
LFEHP
T
I
A
Q
L
A
E
K
L
Y
S
K
QLTAANE
Q
H
V
I
K
L-NQHG-AQN
L
F
C
FPPIS
G
F
G
I
Y
F
K
D
L
A
L
L
L
NEK
A
A
V
Y
G
F
H
---FIEQ----------
D
---
T
R
I
E
Q
----
Y
V
N
C
M
TDIQPEG
P
Y
V
L
L
G
YSAGG
N
L
A
F
E
V
A
Q
A
M
E
RKGLEVS
D
F
I
I
V
D
A
Y
LKEQPLPID----------T---GN-----D----
E
----
S
-------
A
A
Y
L
P
E
A
-
V
---
R
E
K
V
M
K
K
---------------KR
N
Y
Q
-
E
Y
W
A
-----
Q
L
L
NEGH
I
K
A
S
I
H
F
I
EAGIH---PETSGHTGLTKWEGA-C-G-N
Y
S
E
YTGFGA
H
K
D
M
L
EGTYAEK
N
A
D
I
I
L
D
I
L
E
K
ITSN
Q
V
I
L
HKR
1
PsiBlast_PDB
64.29
39%
-38
- C1 -
2VSQ
2
SRFAC_BACSU
A:
[8-1271]
------------
Q
V
Q
D
M
Y
Y
L
S
P
M
Q
E
G
M
L
F
H
A
I
L
N
P
G
Q
S
F
Y
L
E
Q
I
T
M
K
V
K
G
S
L
N
I
-
K
C
L
E
E
S
M
N
V
I
M
D
R
Y
D
V
F
R
T
V
F
I
H
E
--
K
V
K
R
P
V
Q
V
V
L
K
K
R
Q
F
H
I
-
E
E
I
D
L
T
H
L
T
G
S
-
E
Q
T
A
K
I
N
E
Y
K
E
Q
D
K
I
R
G
F
D
L
T
-
R
D
I
---
P
M
R
A
A
I
F
K
K
A
E
E
S
F
E
W
V
W
S
Y
H
H
I
I
L
D
G
W
C
F
G
I
V
V
Q
D
L
F
K
V
Y
N
A
L
R
E
Q
K
P
Y
S
L
P
P
V
K
P
Y
K
----
D
Y
I
K
W
L
E
K
Q
---
D
----
K
Q
A
S
L
R
Y
W
R
E
Y
L
E
G
----
F
E
G
Q
T
T
F
A
E
-
Q
R
K
K
Q
K
D
G
Y
E
P
K
E
L
L
F
S
P
S
E
A
E
T
K
-
A
F
T
E
L
A
K
S
-
Q
H
T
T
L
S
T
A
L
Q
A
V
W
S
V
L
I
S
R
Y
Q
Q
S
G
D
L
A
F
G
T
V
V
S
G
R
P
A
E
I
K
G
V
E
H
M
V
G
L
F
I
N
V
V
P
R
R
V
K
L
S
E
G
I
T
F
N
G
L
L
K
R
L
Q
---
E
Q
S
--------------
L
Q
S
E
P
H
Q
Y
V
P
L
Y
D
I
Q
S
Q
-
A
D
Q
P
-----
K
L
I
D
H
I
I
V
F
E
N
Y
P
L
Q
D
--
A
K
N
-------
E
E
S
S
E
N
G
F
D
M
V
D
V
H
-
V
F
E
K
S
N
Y
D
L
N
L
M
A
--
S
P
G
--
D
---
E
M
L
I
K
L
A
Y
N
E
N
V
F
D
E
A
F
I
L
R
L
K
S
Q
L
L
T
A
I
Q
Q
L
I
Q
N
P
D
Q
P
V
S
T
I
N
L
V
D
D
R
E
R
E
F
L
L
T
G
L
N
P
P
A
---
Q
A
H
-
E
T
K
P
L
T
Y
W
F
K
E
A
V
N
A
N
P
D
A
P
A
L
T
Y
S
G
Q
T
L
S
Y
R
E
L
D
E
E
A
N
R
I
A
R
R
L
Q
K
H
G
A
G
K
G
S
V
V
A
L
Y
T
K
R
S
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
D
P
K
L
P
E
D
R
I
S
Y
M
L
A
D
S
A
A
A
C
L
L
T
H
Q
E
M
K
E
---
Q
A
A
ELP
Y
---
T
---
G
----
T
------------
T
L
F
I
D
D
Q
-----
T
R
F
E
E
Q
A
S
D
P
-
A
T
A
I
------
D
P
----
N
D
P
A
Y
I
M
Y
T
S
G
T
T
G
K
P
K
G
N
I
T
T
H
A
N
I
Q
G
-
L
-
V
K
-
H
V
-
D
--
Y
M
A
F
S
D
Q
D
-
T
F
L
S
V
S
N
Y
A
F
D
A
F
T
F
D
F
Y
A
S
M
L
N
A
A
R
L
I
I
A
D
E
H
T
L
L
D
T
E
R
L
T
D
L
I
L
Q
E
N
V
N
V
M
-
F
A
T
T
A
----
L
F
N
L
L
--
T
D
-
A
G
E
-----
D
W
-
M
K
----
G
L
R
C
I
L
F
G
G
E
R
A
S
V
P
H
V
R
K
--
A
-
L
--
R
I
M
G
P
G
-
K
-
L
I
N
C
Y
G
P
T
E
G
T
V
------
F
A
T
A
H
-----
V
-
V
H
D
LP---
D
--
S
I
--
S
-
S
L
P
--
I
G
K
P
I
S
-
N
A
S
V
Y
I
L
N
E
Q
-
S
Q
L
Q
-
P
-
F
G
A
V
---
G
E
L
C
I
S
G
M
G
V
S
K
G
Y
V
N
R
A
D
L
T
K
E
K
F
I
E
N
P
F
K
--
P
G
E
--
T
L
Y
R
T
G
D
L
A
R
W
L
P
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
A
---
V
V
V
A
D
R
H
------
E
---
S
-
G
D
A
S
I
N
--
A
Y
L
V
--
N
--
R
T
Q
--
L
S
A
E
--
D
---
V
K
A
H
L
K
K
Q
L
P
A
Y
M
V
P
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
-
K
P
D
Q
D
Q
L
A
E
E
-
W
I
G
P
R
N
E
M
E
E
T
I
A
Q
I
W
S
E
V
L
G
R
K
Q
I
G
I
H
D
D
F
F
A
L
G
G
H
A
L
K
A
M
T
A
A
S
R
I
K
K
E
-
L
G
I
D
L
P
V
K
L
L
F
E
A
P
T
I
A
G
I
S
A
--
Y
L
K
N
G
G
S
D
G
L
Q
D
V
T
I
M
-
N
Q
D
Q
-
E
Q
I
I
F
A
F
P
P
V
L
G
Y
G
L
M
Y
Q
N
L
S
S
R
L
-
P
S
Y
K
L
C
A
F
D
---
F
I
E
E
----------
E
---
D
R
L
D
R
----
Y
A
D
L
I
Q
K
L
Q
P
E
G
P
L
T
L
F
G
Y
S
A
G
C
S
L
A
F
E
A
A
K
K
L
E
E
Q
G
R
I
V
Q
R
I
I
M
V
D
S
Y
K
K
Q
G
V
S
---T
V
E
S
D
V
E
A
L
M
N
---
V
N
-----
R
----------------------
E
A
-
V
---
K
H
G
L
K
Q
K
---------------
T
H
A
F
Y
-
S
Y
Y
V
-----
N
-----
Q
V
K
A
D
I
D
L
L
T
S
G
A
D
F
D
I
P
E
-----
W
L
A
S
W
E
E
A
T
T
-
G
-
V
Y
R
M
K
R
G
F
G
T
H
A
E
M
L
Q
G
E
T
L
D
R
N
A
E
I
L
L
E
F
L
N
T
Q
T
---------
54
HHSearch
63.29
40%
-38
- C1 -
2VSQ
2
SRFAC_BACSU
A:
[6-1272]
----------
K
D
Q
V
Q
D
M
Y
Y
L
S
P
M
Q
E
G
M
L
F
H
A
I
L
N
P
G
Q
S
F
Y
L
E
Q
I
T
M
K
V
K
G
S
L
N
I
-
K
C
L
E
E
S
M
N
V
I
M
D
R
Y
D
V
F
R
T
V
F
I
H
--
E
K
V
K
R
P
V
Q
V
V
L
K
K
R
Q
F
H
I
-
E
E
I
D
L
T
H
L
T
G
S
-
E
Q
T
A
K
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N
E
Y
K
E
Q
D
K
I
R
G
F
D
L
T
-
R
D
I
---
P
M
R
A
A
I
F
K
K
A
E
E
S
F
E
W
V
W
S
Y
H
H
I
I
L
D
G
W
C
F
G
I
V
V
Q
D
L
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K
V
Y
N
A
L
R
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Q
K
P
Y
S
L
P
P
V
K
P
Y
K
----
D
Y
I
K
W
L
E
K
Q
---
D
----
K
Q
A
S
L
R
Y
W
R
E
Y
L
E
G
----
F
E
G
Q
T
T
F
A
E
Q
R
K
K
Q
-
K
D
G
Y
E
P
K
E
L
L
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S
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A
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K
-
A
F
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L
A
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-
Q
H
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T
L
S
T
A
L
Q
A
V
W
S
V
L
I
S
R
Y
Q
Q
S
G
D
L
A
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G
T
V
V
S
G
R
P
A
E
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K
G
V
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H
M
V
G
L
F
I
N
V
V
P
R
R
V
K
L
S
E
G
I
T
F
N
G
L
L
K
R
L
Q
---
E
Q
S
--------------
L
Q
S
E
P
H
Q
Y
V
P
L
Y
D
I
Q
S
Q
A
D
Q
P
------
K
L
I
D
H
I
I
V
F
E
N
Y
P
L
Q
D
A
K
N
E
---------
E
S
S
E
N
G
F
D
M
V
D
V
H
-
V
F
E
K
S
N
Y
D
L
N
L
M
A
--
S
P
G
--
D
---
E
M
L
I
K
L
A
Y
N
E
N
V
F
D
E
A
F
I
L
R
L
K
S
Q
L
L
T
A
I
Q
Q
L
I
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N
P
D
Q
P
V
S
T
I
N
L
V
D
D
R
E
R
E
F
L
L
T
G
L
N
P
P
A
---
Q
-
A
H
E
T
K
P
L
T
Y
W
F
K
E
A
V
N
A
N
P
D
A
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R
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L
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L
A
D
S
A
A
A
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L
L
T
H
Q
E
M
K
E
---
Q
A
A
---
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LPY
T
---
G
----
T
------------
T
L
F
I
D
D
Q
-----
T
R
F
E
E
Q
A
S
D
P
-
A
T
A
I
------
D
P
----
N
D
P
A
Y
I
M
Y
T
S
G
T
T
G
K
P
K
G
N
I
T
T
H
A
N
I
Q
G
-
L
-
V
K
-
H
V
-
D
---
Y
M
A
F
S
D
Q
D
T
F
L
S
V
S
N
Y
A
F
D
A
F
T
F
D
F
Y
A
S
M
L
N
A
A
R
L
I
I
A
D
E
H
T
L
L
D
T
E
R
L
T
D
L
I
L
Q
E
N
V
N
V
M
-
F
A
T
T
A
----
L
F
N
L
L
--
T
D
-
A
G
E
-----
D
W
-
M
K
----
G
L
R
C
I
L
F
G
G
E
R
A
S
-
V
P
H
V
R
--
K
-
A
--
L
R
I
M
G
P
G
K
-
L
I
N
C
Y
G
P
T
E
G
T
V
------
F
A
T
A
H
-----
V
-
V
H
D
LP---
D
--
S
I
--
S
-
S
L
P
--
I
G
K
P
I
S
-
N
A
S
V
Y
I
L
N
E
Q
-
S
Q
L
Q
-
P
-
F
G
A
V
---
G
E
L
C
I
S
G
M
G
V
S
K
G
Y
V
N
R
A
D
L
T
K
E
K
F
I
E
N
P
F
K
--
P
G
E
--
T
L
Y
R
T
G
D
L
A
R
W
L
P
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
A
---
V
V
V
A
-
D
R
------
H
---
E
S
G
D
A
S
I
N
--
A
Y
L
V
--
N
--
R
T
Q
--
L
S
A
E
--
D
---
V
K
A
H
L
K
K
Q
L
P
A
Y
M
V
P
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
-
K
P
D
Q
D
Q
L
-
A
E
E
W
I
G
P
R
N
E
M
E
E
T
I
A
Q
I
W
S
E
V
L
G
R
K
Q
I
G
I
H
D
D
F
F
A
L
G
G
H
A
L
K
A
M
T
A
A
S
R
I
K
K
E
-
L
G
I
D
L
P
V
K
L
L
F
E
A
P
T
I
A
G
I
S
A
Y
L
K
N
G
G
S
D
G
L
Q
--
D
V
T
I
M
-
N
Q
D
Q
-
E
Q
I
I
F
A
F
P
P
V
L
G
Y
G
L
M
Y
Q
N
L
S
S
R
L
P
-
S
Y
K
L
C
A
F
D
---
F
I
E
E
----------
E
---
D
R
L
D
R
----
Y
A
D
L
I
Q
K
L
Q
P
E
G
P
L
T
L
F
G
Y
S
A
G
C
S
L
A
F
E
A
A
K
K
L
E
E
Q
G
R
I
V
Q
R
I
I
M
V
D
S
Y
K
K
Q
G
V
S
--------------T
V
E
S
D
-----
V
----
E
----
A
-------
L
M
N
V
N
R
---EAV
K
H
G
L
K
Q
K
---------------
T
H
A
F
Y
-
S
Y
Y
V
-----
N
-----
Q
V
K
A
D
I
D
L
L
T
S
G
A
D
---
F
D
I
--
P
E
W
L
A
S
W
E
E
A
-
T
-
T
G
V
Y
R
M
K
R
G
F
G
T
H
A
E
M
L
Q
G
E
T
L
D
R
N
A
E
I
L
L
E
F
L
N
T
Q
T
V
--------
10
PsiBlast_PDB
51.77
27%
2
- C1 -
4ZXJ
1
ENTF_ECOLI
A:
[3-1042]
------------------
P
L
V
A
A
Q
P
G
I
W
M
A
E
K
L
S
E
L
P
S
A
W
S
V
A
H
Y
V
E
L
T
G
E
V
D
S
-
P
L
L
A
R
A
V
V
A
G
L
A
Q
A
D
T
L
R
M
R
F
T
E
D
N
G
E
V
---
W
Q
W
V
D
D
A
L
T
F
E
L
---
P
E
I
I
D
L
R
T
N
I
D
P
H
G
T
A
Q
A
L
M
Q
A
D
L
Q
Q
--
D
L
R
-
V
D
S
GKP
L
V
F
H
Q
L
I
Q
V
A
D
N
R
W
Y
W
Y
Q
R
Y
H
H
L
L
V
D
G
F
S
F
P
A
I
T
R
Q
I
A
N
I
Y
C
T
W
L
R
G
E
P
T
P
A
S
P
F
T
P
F
A
D
V
V
E
E
Y
Q
Q
Y
R
E
S
E
---
A
----
W
Q
R
D
A
A
F
W
A
E
Q
R
R
Q
----
L
P
P
P
A
S
L
S
P
A
P
L
P
G
R
S
A
S
A
D
----
I
L
R
L
K
L
E
F
T
D
G
E
F
R
Q
L
A
T
Q
L
S
G
V
Q
R
T
D
L
A
L
A
L
A
A
L
W
L
G
R
L
C
N
R
M
D
Y
A
A
G
F
I
F
M
R
R
L
G
S
--
A
A
L
T
A
T
G
P
V
L
N
V
L
P
L
G
I
H
I
A
A
Q
E
T
L
P
E
L
A
T
R
L
A
A
Q
L
K
K
M
--------------
R
R
H
Q
R
Y
D
A
E
Q
I
V
R
D
S
G
R
A
A
G
D
E
-----
P
L
F
G
P
V
L
N
I
K
V
F
D
Y
Q
L
D
I
P
D
V
-------
Q
A
Q
T
H
T
---------
L
A
T
G
P
V
N
D
L
E
L
A
L
--
F
P
D
VH
G
---
D
L
S
I
E
I
L
A
N
K
Q
R
Y
D
E
P
T
L
I
Q
H
A
E
R
L
K
M
L
I
A
Q
F
A
A
D
P
A
L
L
C
G
D
V
D
I
M
L
P
G
E
Y
A
Q
L
A
-
Q
L
N
A
T
Q
---
V
E
I
P
E
T
-
T
L
S
A
L
V
A
E
Q
A
A
K
T
P
D
A
P
A
L
A
D
A
R
Y
L
F
S
Y
R
E
M
R
E
Q
V
V
A
L
A
N
L
L
R
E
R
G
V
K
P
G
D
S
V
A
V
A
L
P
R
S
V
F
L
T
L
A
L
H
A
I
V
E
A
G
A
A
W
L
P
L
D
T
G
Y
P
D
D
R
L
K
M
M
L
E
D
A
R
P
S
L
L
I
T
T
D
--
D
Q
---
L
P
R
---
F
---
S
---
D
VPN
L
T
------------
S
L
C
Y
N
A
P
------
L
T
P
Q
G
S
A
P
L
-
Q
L
S
Q
-------
P
----
H
H
T
A
Y
I
I
F
T
S
G
S
T
G
R
P
K
G
V
M
V
G
Q
T
A
I
V
N
R
L
-
L
W
-
M
Q
-
N
--
H
Y
P
L
T
G
E
D
-
V
V
A
Q
K
T
P
C
S
F
D
V
S
V
W
E
F
F
W
P
F
I
A
G
A
K
L
V
M
A
E
P
E
A
H
R
D
P
L
A
M
Q
Q
F
F
A
E
Y
G
V
T
T
T
H
F
V
P
S
M
----
L
A
A
F
V
--
A
S
-
L
T
P
-----
Q
T
-
A
R
Q
SCA
T
L
K
Q
V
F
C
S
G
E
A
L
--
P
A
D
L
C
--
R
-
E
--
W
Q
Q
L
T
G
A
P
-
L
H
N
L
Y
G
P
T
E
A
A
V
------
D
V
S
W
Y
P
AFG
E
E
-
L
A
Q
-----
V
--
R
G
--
S
-
S
V
P
--
I
G
Y
P
V
W
-
N
T
G
L
R
I
L
D
A
M
-
M
H
P
V
-
P
-
P
G
V
A
---
G
D
L
Y
L
T
G
I
Q
L
A
Q
G
Y
L
G
R
P
D
L
T
A
S
R
F
I
A
D
P
F
A
--
P
G
E
--
R
M
Y
R
T
G
D
V
A
R
W
L
D
N
G
A
V
E
Y
L
G
R
S
D
D
Q
L
K
I
R
G
Q
R
I
E
L
G
E
I
D
R
V
M
Q
A
L
P
D
V
E
Q
A
V
T
H
A
C
V
I
-
N
Q
------
A
AAT
G
-
G
D
A
R
Q
L
--
V
G
Y
L
--
V
--
S
Q
S
--
G
L
P
L
--
D
T
S
A
L
Q
A
Q
L
R
E
T
L
P
P
H
M
V
P
V
V
L
L
Q
L
P
Q
L
P
L
S
A
N
G
K
L
D
R
K
A
L
P
-
L
P
E
L
K
A
Q
A
P
G
R
A
--
P
K
A
G
S
E
T
I
I
A
A
A
F
S
S
L
L
G
C
D
V
Q
D
A
D
A
D
F
F
A
L
G
G
H
S
L
L
A
M
K
L
A
A
Q
L
S
R
Q
-
V
A
R
Q
V
T
P
G
Q
V
M
V
A
S
T
V
A
K
L
A
T
I
I
D
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
46.78
39%
-22
- C1 -
5ES8
1
LGRA_BREPA
B:
[196-770]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
G
E
K
P
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
A
L
H
E
E
---
K
A
--------
N
---
G
----
A
------------
C
D
I
I
D
V
H
DP---
D
S
Y
S
E
N
T
N
N
L
-
P
H
V
N
------
R
P
----
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
-
F
-
C
E
W
Y
R
-
P
--
Y
F
G
V
T
P
A
D
-
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
-
Y
L
P
T
G
----
A
A
E
Q
F
--
M
Q
-
M
D
N
-----
Q
S
-
F
R
-------
V
V
I
T
G
G
D
V
L
K
-
K
I
E
R
N
--
G
-
T
--------
Y
K
-
L
Y
N
G
Y
G
P
T
E
C
T
I
------
M
V
T
M
F
-----
E
-
V
D
K
-----
P
--
Y
A
--
N
--
I
P
--
I
G
K
P
I
D
-
R
T
R
I
L
I
L
D
E
A
-
L
A
L
Q
-
P
-
I
G
V
A
---
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
-
Q
--
T
G
E
--
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
---
T
V
L
A
-
K
E
------
Q
A--
D
-
G
R
K
Y
L
V
--
G
Y
Y
V
--
A
--
P
E
E
--
I
P
H
G
--
E
---
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
Q
A
D
A
E
L
L
--
D
Y
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
N
--
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
-
K
R
L
L
T
E
Q
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
46.27
39%
-26
- C1 -
5ES8
1
LGRA_BREPA
A:
[196-770]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
G
E
K
P
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
A
L
H
E
E
---
K
A
--------
N
---
G
----
A
------------
C
D
I
I
D
V
H
DP---
D
S
Y
S
E
N
T
N
N
L
-
P
H
V
N
------
R
P
----
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
-
F
-
C
E
W
Y
R
-
P
--
Y
F
G
V
T
P
A
D
-
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
-
Y
L
P
T
G
----
A
A
E
Q
F
--
M
Q
-
M
D
N
-----
Q
S
-
F
R
-------
V
V
I
T
G
G
D
V
L
K
-
K
I
E
R
N
--
G
-
T
--------
Y
K
-
L
Y
N
G
Y
G
P
T
E
C
T
I
------
M
V
T
M
F
-----
E
-
V
D
K
-----
P
--
Y
A
--
N
--
I
P
--
I
G
K
P
I
D
-
R
T
R
I
L
I
L
D
E
A
-
L
A
L
Q
-
P
-
I
G
V
A
---
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
-
Q
--
T
G
E
--
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
---
T
V
L
A
-
K
E
------
Q
A--
D
-
G
R
K
Y
L
V
--
G
Y
Y
V
--
A
--
P
E
E
--
I
P
H
G
--
E
---
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
-----------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
N
--
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
-
K
R
L
L
T
E
Q
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
45.73
39%
-48
- C1 -
5ES8
1
LGRA_BREPA
A:
[202-768]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
A
L
H
E
E
---
K
A
N
---
G
---
A
---
C
----
D
------------
I
I
D
V
H
D
P
-----
D
S
Y
S
E
N
T
N
N
L
-
P
H
V
N
------
R
P
----
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
-
F
-
C
E
-
W
Y
-
R
--
P
Y
F
G
V
T
P
A
D
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
-
Y
L
P
T
G
----
A
A
E
Q
F
--
M
Q
-
M
--------
D
-
N
Q
----
S
F
R
V
V
I
T
G
G
D
V
L
K
-
K
I
E
-----------
R
N
G
T
Y
K
-
L
Y
N
G
Y
G
P
T
E
C
T
I
------
M
V
T
M
F
-----
E
-
V
D
K
--------
P
Y
--
A
-
N
I
P
--
I
G
K
P
I
D
-
R
T
R
I
L
I
L
D
E
A
-
L
A
L
Q
-
P
-
I
G
V
A
---
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
Q
---
T
G
E
--
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
G
Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
---
T
V
L
A
-
K
E
------
Q
---
A
D
G
R
K
Y
L
V
--
G
Y
Y
V
--
A
--
P
E
E
--
I
P
H
G
--
E
---
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
-
D
V
----------
V
A
P
T
D
E
L
E
Q
Q
L
A
Q
V
W
S
H
V
L
G
I
P
Q
M
G
I
D
D
H
F
L
E
R
G
G
D
S
I
K
V
M
Q
L
I
H
Q
L
K
N
--
I
G
L
S
L
R
Y
D
Q
L
F
T
H
P
T
I
R
Q
L
K
R
L
L
T
E
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
44.71
29%
-58
- C1 -
4DG9
1
?
A:
[18-604]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
---
L
D
L
Y
A
H
P
T
V
V
A
R
F
S
E
M
A
A
L
H
P
H
R
E
A
I
R
D
R
F
G
S
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
Y
L
L
E
H
Y
P
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
C
R
L
I
L
D
C
S
T
T
P
T
---
P
---------
A
---
N
----
G
------------
L
P
C
V
P
V
R
-----
H
L
P
A
A
P
A
S
V
A
-
R
P
C
F
------
A
A
----
D
Q
I
A
Y
I
N
F
S
S
G
T
T
G
R
P
K
A
I
A
C
T
H
A
G
I
T
R
-
L
-
C
L
-
G
Q
-
S
--
F
L
A
F
A
P
Q
M
-
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
I
W
G
A
L
L
N
G
G
C
C
V
L
N
D
L
G
P
-
L
D
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
-
W
L
T
A
S
----
L
F
N
T
L
--
V
D
-
L
D
P
-----
D
C
-
L
G
----
G
L
R
Q
L
L
T
G
G
D
I
L
S
-
V
P
H
V
R
--
R
-
A
--
L
L
R
H
P
R
L
H
-
L
V
N
G
Y
G
P
T
E
N
T
T
------
F
T
C
C
H
-----
V
-
V
T
D
-----
D
--
D
L
E
E
D
-
D
I
P
--
I
G
K
A
I
A
-
G
T
A
V
L
L
L
D
E
H
-
G
Q
E
I
-
A
E
P
D
R
A
---
G
E
I
V
A
F
G
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
R
A
S
F
V
E
L
P
Y
R
G-
R
L
L
--
R
A
Y
R
T
G
D
R
A
R
Y
D
E
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
C
---
A
L
L
V
-
R
E
------
R
---
N
-
G
V
K
Q
L
L
--
C
A
W
T
--
G
--
K
------
A
D
--
A
---
S
P
Q
A
L
L
R
Q
L
P
T
W
Q
R
P
H
A
C
V
R
V
E
A
L
P
L
T
A
H
G
K
L
D
R
A
A
L
L
-
R
R
L
-----------
E
L
D
P
D
Q
R
G
C
A
Q
L
W
S
E
L
L
G
C
E
---
V
G
A
D
F
F
L
C
G
G
N
S
L
L
A
L
Q
L
V
A
L
C
Q
S
A
G
A
G
A
N
L
G
L
A
D
L
Q
A
N
S
R
L
D
Q
F
S
R
L
L
R
S
H
G
L
A
P
E
R
L
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
43.98
76%
-109
* C2 *
2CBG
1
?
A:
[7-225]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
A
G
E
Q
H
V
I
Q
L
-
N
Q
Q
G
-
G
K
N
L
F
C
F
P
P
I
S
G
F
G
I
Y
F
K
D
L
A
L
Q
L
N
H
K
A
A
V
Y
G
F
H
---
F
I
E
E
----------
D
---
S
R
I
E
Q
----
Y
V
S
R
I
T
E
I
Q
P
E
G
P
Y
V
L
L
G
Y
S
A
G
G
N
L
A
F
E
V
V
Q
A
M
E
Q
K
G
L
E
V
S
D
F
I
I
V
D
A
Y
K
K
D
Q
S
I
T
A
D
------------------------------------------
L
P
E
A
-
V
---
R
E
T
V
M
Q
K
---------------
K
R
C
Y
Q
-
E
Y
W
A
-----
Q
L
I
N
E
G
R
I
K
S
N
I
H
F
I
E
A
G
I
Q
---
T
E
T
S
G
A
M
V
L
Q
K
W
Q
D
A
-
A
E
E
-
G
Y
A
E
Y
T
G
Y
G
A
H
K
D
M
L
E
G
E
F
A
E
K
N
A
N
I
I
L
N
I
L
D
K
I
----------
55
HHSearch
43.97
24%
5
- C1 -
4ZXH
3
?
A:
[4-1318]
----
N
N
L
A
R
L
E
P
E
V
L
S
R
H
A
I
S
S
E
Q
L
G
I
W
Y
I
Q
R
L
E
P
T
C
S
A
Y
N
M
V
V
A
F
D
V
K
V
N
Q
S
L
G
N
K
P
I
E
I
L
E
A
V
M
H
D
Y
P
L
L
R
V
S
M
P
A
--
N
-
D
Q
G
I
E
Q
L
I
W
D
R
V
Y
P
N
I
-
I
F
S
D
A
R
H
I
E
-----
A
S
D
L
T
Q
L
V
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Q
D
T
K
Q
P
F
D
L
T
-
Q
P
P
---
L
W
R
I
H
C
Y
E
C
G
Q
N
H
Y
V
I
A
F
V
I
H
H
A
L
M
D
F
W
S
I
G
L
L
L
R
D
V
S
K
R
F
G
L
V
A
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S
D
A
---
V
N
G
I
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F
V
----
Q
Y
A
D
K
Q
Q
S
S
VID
D
----
T
D
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S
L
I
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W
K
N
A
L
K
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----
A
P
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V
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P
L
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Y
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G
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L
L
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K
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N
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N
N
L
V
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R
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--
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L
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A
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M
D
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A
D
Q
T
L
R
Q
F
T
Q
Q
V
Q
---
E
Q
L
--------------
R
Q
S
L
K
H
Q
K
I
A
F
S
R
V
V
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A
V
S
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K
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DGSIN
P
L
A
Q
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L
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G
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A
T
L
V
G
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L
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L
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V
R
Q
Q
E
G
Q
L
D
I
T
L
E
M
G
G
E
Y
Q
--
G
---
E
L
V
G
V
L
K
Y
N
T
D
L
F
S
A
Q
S
A
E
N
M
V
Q
L
L
Q
A
V
L
S
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M
V
A
H
P
E
R
K
I
V
E
L
D
I
A
P
D
Y
K
D
G
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Q
F
E
A
L
R
G
K
A
---
T
D
-
Y
A
Q
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D
L
F
A
M
I
L
K
Q
I
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G
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N
H
A
L
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--
H
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Y
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G
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G
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G
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L
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A
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L
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N
I
I
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Q
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---
G
L
N
---
V
---
S
---
V
----
P
------------
R
L
D
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N
Q
A
-----
G
V
--
V
A
L
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V
-
R
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T
L
------
A
F
----
G
D
I
A
Y
V
M
Y
T
S
----
K
P
K
G
V
R
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G
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P
S
I
I
N
-
F
-
L
L
-
S
M
-
N
--
D
R
L
Q
V
T
T
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T
Q
L
L
A
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T
Y
A
F
D
I
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I
L
E
L
L
I
P
L
M
Y
G
G
V
V
H
V
C
P
R
E
V
S
Q
D
G
I
Q
L
V
D
Y
L
N
A
K
S
I
N
V
L
-
Q
A
T
P
A
----
T
W
K
M
L
--
L
D
-
S
E
W
------
S
-
G
N
----
A
G
L
T
A
L
C
G
G
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A
L
D
-
T
I
L
A
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--
K
-
L
--
L
G
K
V
--
G
C
-
L
W
N
V
Y
G
P
T
E
T
T
V
------
W
S
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A
A
-----
R
-
I
T
---------
D
A
--
K
-
Y
I
D
--
L
G
E
P
L
A
-
N
T
Q
L
Y
V
L
D
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Q
-
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V
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P
-
P
G
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M
---
G
E
L
W
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G
G
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G
L
A
V
D
Y
W
Q
R
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L
T
D
A
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F
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S
L
P-
N
A
G
--
R
L
Y
R
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G
D
K
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C
L
R
T
D
G
R
L
T
H
H
G
R
L
D
F
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K
I
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G
F
R
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L
G
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I
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N
V
L
K
Q
I
D
G
I
T
D
A
---
V
V
L
V
-
K
T
------
T
---
G
D
N
D
Q
K
L
V
--
A
Y
V
T
--
G
--
Q
E
---
L
D
I
A
--
G
---
L
K
K
N
L
Q
I
H
L
P
A
Y
M
V
P
S
A
F
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L
D
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M
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A
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K
K
L
D
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K
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-
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F
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--
N
D
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V
A
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C
T
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F
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L
L
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K
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N
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A
-
F
G
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A
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N
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R
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---
S
P
G
L
IEADAAEVA
I
E
---
E
M
A
T
L
----
Y
I
A
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M
Q
K
M
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Q
G
P
Y
F
L
G
G
W
C
F
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A
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A
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R
Q
L
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Q
Q
V
T
G
I
V
M
I
D
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R
A
P
I
P
E
N
V
P
E
DAD-------
D
---
A
M
L
L
S
W
F
A
R
D
L
A
A
PYG
K
K
L
T
IP
A
Q
Y
L
R
E
L
S
P
D
Q
M
---
F
D
H
V
L
K
E
A
K
A
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NVLPLDAD
P
S
D
F
R
L
Y
F
D
T
Y
L
A
N
G
I
A
L
Q
T
Y
F
P
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L
V
K
A
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D
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---
Q
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--
G
E
S
L
G
W
D
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-
V
-
K
D
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L
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M
Y
A
E
N
V
V
A
V
A
Q
T
I
D
Q
M
Y
P
------------
45
Fugue
43.15
41%
-20
- C1 -
1AMU
4
GRSA_ANEMI
A:
[17-530]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
H
E
E
E
Q
Y
L
F
A
V
N
N
T
K
---
A
E
Y
P
R
D
K
T
I
H
Q
L
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N
V
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C
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N
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L
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Y
H
E
L
N
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K
A
N
Q
L
A
R
I
F
I
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K
G
I
G
K
D
T
L
V
G
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M
M
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K
S
I
D
L
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I
L
A
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L
K
A
G
G
A
Y
V
P
I
D
I
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Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
T
Q
K
H
L
V
H
---
L
I
H
---
N
---
I
---------QFN
G
Q
V
E
I
FEED
T
I
K
I
R
----------
E
G
T
N
L
H
--
V
P
S
K
------
S
T
-----
D
L
A
Y
V
I
Y
T
S
-----
P
K
G
T
M
L
E
H
K
G
I
S
N
-
L
-
K
V
-
F
F
-
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NS
L
N
-
V
T
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D
-
R
I
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Q
F
A
S
I
S
F
D
A
S
V
W
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M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
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I
T
V
I
-
T
L
P
P
T
----
Y
V
V
H
L
----D
P
E
R
-----
I
---
L
----
S
I
Q
T
L
I
T
A
G
S
A
T
S
-
P
S
L
V
N
--
K
-
W
--
K
E
K
V
---
T
-
Y
I
N
A
Y
G
P
T
E
T
T
I
------
C
A
T
T
W
-----
V
-
A
T
K
-----
E
--
T
I
--
G
H
S
V
P
--
I
G
A
P
I
Q
-
N
T
Q
I
Y
I
V
D
E
-N
L
Q
L
K
-
S
-
V
G
E
A
---
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
V
D
N
P
F
V
--
P
G
E
--
K
L
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
---
A
V
S
V
-
H
K
------
D
---
H
-
Q
E
Q
P
Y
L
--
C
A
Y
F
--
V
S
E-
K
H
--
I
P
L
E
--
Q
---
L
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
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Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
-
E
P
D
L
T
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
42.80
39%
-35
- C1 -
5ES9
1
LGRA_BREPA
A:
[196-770]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
G
E
K
P
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
A
L
H
E
E
---
K
A
--------
N
---
G
----
A
------------
C
D
I
I
D
V
H
DP---
D
S
Y
S
E
N
T
N
N
L
-
P
H
V
N
------
R
P
----
D
D
L
V
Y
V
M
Y
T
S
----
L
A
K
G
V
M
I
E
H
H
N
L
V
N
-
F
-
C
E
W
Y
R
-
P
--
Y
F
G
V
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P
A
D
-
K
A
L
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Y
S
S
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A
A
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Y
D
L
D
A
L
N
D
Y
C
N
Q
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S
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Y
L
P
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G
----
A
A
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Q
F
--
M
Q
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M
D
N
-----
Q
S
-
F
R
-------
V
V
I
T
G
G
D
V
L
K
-
K
I
E
R
N
--
G
-
T
--------
Y
K
-
L
Y
N
G
Y
G
P
T
E
C
T
I
------
M
V
T
M
F
-----
E
-
V
D
K
-----
P
--
Y
A
--
N
--
I
P
--
I
G
K
P
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A
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Q
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G
V
A
---
G
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G
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G
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G
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L
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A
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--
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G
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--
R
M
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R
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G
D
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A
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N
I
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F
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G
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L
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N
L
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Y
R
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P
G
E
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P
F
L
M
N
H
P
L
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L
T
---
T
V
L
A
-
K
E
------
Q
A--
D
-
G
R
K
Y
L
V
--
G
Y
Y
V
--
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--
P
E
E
--
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--
E
---
L
R
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W
L
G
N
D
L
P
D
Y
M
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Y
F
V
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M
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A
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A
N
G
K
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D
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R
A
L
P
D
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Q
A
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A
-------
V
A
P
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D
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L
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Q
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A
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G
I
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M
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D
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F
L
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G
G
D
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K
V
M
Q
L
I
H
Q
L
K
N
--
I
G
L
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L
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Y
D
Q
L
F
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H
P
T
I
R
Q
L
-
K
R
L
L
T
E
Q
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
42.52
41%
-12
- C1 -
1AMU
4
GRSA_ANEMI
A:
[20-530]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
E
Q
Y
L
F
A
V
N
N
T
K
---
A
E
Y
P
R
D
K
T
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
T
Q
K
H
L
V
H
L
I
H
N
I
Q
---
F
---
N
---
G
----
Q
------------
V
E
I
F
E
E
D
-----
T
I
K
I
R
E
G
T
N
L
-
H
V
P
S
------
K
S
----
T
D
L
A
Y
V
I
Y
T
S
-----
P
K
G
T
M
L
E
H
K
G
I
S
N
-
L
K
V
F
-
F
E
-
N
--
S
L
N
V
T
E
K
D
-
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
I
-
T
L
P
P
T
----
Y
V
V
H
L
--
D
P
-
E
R
---------
I
L
----
S
I
Q
T
L
I
T
A
G
S
A
T
S
-
P
S
L
V
N
--
K
-
W
--
K
E
K
V
T
Y
I
----
N
A
Y
G
P
T
E
T
T
I
------
C
A
T
T
W
-----
V
-
A
T
K
-----
E
--
T
I
--
G
H
S
V
P
--
I
G
A
P
I
Q
-
N
T
Q
I
Y
I
V
D
E
N
-
L
Q
L
K
-
S
-
V
G
E
A
---
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
V
D
N
P
F
V
--
P
G
E
--
K
L
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
---
A
V
S
V
-
H
-------
K
---
D
-
H
Q
E
Q
P
Y
L
C
A
Y
F
V
--
S
--
E
K
H
--
I
P
L
E
--
Q
---
L
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
-
E
P
D
L
T
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
41.84
41%
-12
- C1 -
1AMU
4
GRSA_ANEMI
B:
[20-530]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
E
Q
Y
L
F
A
V
N
N
T
K
---
A
E
Y
P
R
D
K
T
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
T
Q
K
H
L
V
H
LIH
N
-
Q
---
F
---
N
---
G
----
Q
------------
V
E
I
F
E
E
D
-----
T
I
K
I
R
E
G
T
N
L
-
H
V
P
S
------
K
S
----
T
D
L
A
Y
V
I
Y
T
-----
N
P
K
G
T
M
L
E
H
K
G
I
S
N
-
L
K
V
F
-
F
E
-
N
--
S
L
N
V
T
E
K
D
-
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
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N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
I
-
T
L
P
P
T
----
Y
V
V
H
L
--
D
P
-
E
R
---------
I
L
----
S
I
Q
T
L
I
T
A
G
S
A
T
S
-
P
S
L
V
N
--
K
-
W
--
K
E
K
V
T
Y
I
----
N
A
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G
P
T
E
T
T
I
------
C
A
T
T
W
-----
V
-
A
T
K
-----
E
--
T
I
--
G
H
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V
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--
I
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L
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-
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-
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G
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A
---
G
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L
C
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G
G
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G
L
A
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Y
W
K
R
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L
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K
F
V
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N
P
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--
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--
K
L
Y
K
T
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D
Q
A
R
W
L
S
D
G
N
I
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Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
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V
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L
E
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V
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L
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H
M
Y
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---
A
V
S
V
-
H
-------
K
---
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--
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L
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--
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---
L
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L
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Y
M
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L
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M
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L
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S
N
G
K
I
D
R
K
Q
L
P
-
E
P
D
L
T
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
41.59
36%
-62
- C1 -
4GR5
3
?
A:
[73-467]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
A
C
V
H
E
L
F
E
A
Q
A
A
R
A
P
D
A
V
A
L
L
H
E
A
D
E
L
T
Y
G
A
L
N
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R
A
N
R
L
A
H
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L
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G
L
G
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A
P
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T
L
V
G
V
H
L
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R
G
F
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M
V
V
A
L
L
A
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L
K
A
G
G
G
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T
M
L
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P
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F
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R
L
A
L
S
L
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D
T
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A
P
L
L
V
T
S
R
P
L
S
G
---
R
L
T
---
G
---
T
--------
T
------------
T
L
Y
V
E
D
------------
A
G
N
L
-
A
T
G
V
------
G
P
----
E
D
V
A
C
V
M
F
T
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G
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-
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L
-
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----
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A
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-
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L
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A
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----
L
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N
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-
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P
-----
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A
-
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E
----
G
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A
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N
G
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G
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A
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------
F
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-----
A
-
V
V
A
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L
--
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--
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G
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M
Y
R
T
G
D
L
A
R
R
R
A
D
G
V
L
E
Y
V
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
41.59
25%
-6
- C1 -
4ZXJ
1
ENTF_ECOLI
A:
[2-1041]
-----------------
L
P
L
V
A
A
Q
P
G
I
W
M
A
E
K
L
S
E
L
P
S
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---
P
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A
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D
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---
L
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L
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Y
C
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P
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----
D
V
V
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Y
---
R
E
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A
W
Q
R
D
A
A
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A
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----
L
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P
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L
S
P
A
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L
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L
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---------------
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---
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----
N
------------
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L
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Q
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A
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L
Q
L
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------
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P
----
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I
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S
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----
M
L
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A
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S
L
T
P
Q
T
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S
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C
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----
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A
D
L
C
R
--
E
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W
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Q
L
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G
A
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L
H
N
L
Y
G
P
T
E
A
A
V
------
D
V
S
W
Y
-----
P
-
A
F
G
E
E
L
A
Q
V
--
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--
S
-
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V
P
--
I
G
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-
N
T
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L
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V
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L
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L
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F
A
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E
--
R
M
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D
V
A
R
W
L
D
N
G
A
V
E
Y
L
G
R
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D
D
Q
L
K
I
R
G
Q
R
I
E
L
G
E
I
D
R
V
M
Q
A
L
P
D
V
E
Q
A
---
V
T
H
A
-
C
V
INQAAA
T
G--
G
-
D
A
R
Q
L
V
--
G
Y
L
V
--
S
--
Q
S
G
LP
L
D
T
S
--
A
---
L
Q
A
Q
L
R
E
T
L
P
P
H
M
V
P
V
V
L
L
Q
L
P
Q
L
P
L
S
A
N
G
K
L
D
R
K
A
L
P
-
L
P
E
L
K
A
--
Q
A
P
G
R
A
P
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A
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S
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T
I
I
A
A
A
F
S
S
L
L
G
C
D
V
Q
D
A
D
A
D
F
F
A
L
G
G
H
S
L
L
A
M
K
L
A
A
Q
L
S
R
Q
-
V
A
R
Q
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T
P
G
Q
V
M
V
A
S
T
V
A
K
L
A
T
I
I
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
41.59
39%
-30
- C1 -
5ES5
1
LGRA_BREPA
B:
[196-685]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
G
E
K
P
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
A
L
H
E
E
---
K
A
--------
N
---
G
----
A
------------
C
D
I
I
D
V
H
DP---
D
S
Y
S
E
N
T
N
N
L
-
P
H
V
N
------
R
P
----
D
D
L
V
Y
V
M
Y
T
S
G
S
T
G
L
A
K
G
V
M
I
E
H
H
N
L
V
N
-
F
-
C
E
W
Y
R
-
P
--
Y
F
G
V
T
P
A
D
-
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
-
Y
L
P
T
G
----
A
A
E
Q
F
--
M
Q
-
M
D
N
-----
Q
S
-
F
R
-------
V
V
I
T
G
G
D
V
L
K
-
K
I
E
R
N
--
G
-
T
--------
Y
K
-
L
Y
N
G
Y
G
P
T
E
C
T
I
------
M
V
T
M
F
-----
E
-
V
D
K
-----
P
--
Y
A
--
N
--
I
P
--
I
G
K
P
I
D
-
R
T
R
I
L
I
L
D
E
A
-
L
A
L
Q
-
P
-
I
G
V
A
---
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
-
Q
--
T
G
E
--
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
N
L
V
K
I
R
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Y
R
I
E
P
G
E
I
E
P
F
L
M
N
H
P
L
I
E
L
T
---
T
V
L
A
-
K
E
------
Q
A--
D
-
G
R
K
Y
L
V
--
G
Y
Y
V
--
A
--
P
E
E
--
I
P
H
G
--
E
---
L
R
E
W
L
G
N
D
L
P
D
Y
M
I
P
T
Y
F
V
H
M
K
A
F
P
L
T
A
N
G
K
V
D
R
R
A
L
P
D
V
Q
A
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
41.42
36%
-51
- C1 -
4GR5
2
?
C:
[72-467]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
G
A
C
V
H
E
L
F
E
A
Q
A
A
R
A
P
D
A
V
A
L
L
H
E
A
D
E
L
T
Y
G
A
L
N
E
R
A
N
R
L
A
H
R
L
V
G
L
G
V
A
P
G
T
L
V
G
V
H
L
E
R
G
F
D
M
V
V
A
L
L
A
V
L
K
A
G
G
G
Y
T
M
L
D
P
Q
F
P
V
E
R
L
A
L
S
L
E
D
T
G
A
P
L
L
V
T
S
R
P
L
S
G
---
R
L
T
---
G
---
T
---
T
----
T
------------
L
Y
V
E
D
---------------
P
A
G
N
L
A
T
GV----
G
P
----
E
D
V
A
C
V
M
F
T
S
G
S
T
G
R
P
K
G
V
M
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P
H
R
A
L
T
G
-
T
-
Y
L
-
G
Q
-
D
--
Y
A
G
F
G
P
D
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-
V
F
L
Q
C
S
P
V
S
W
D
A
F
G
L
E
L
F
G
A
L
L
F
G
A
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C
-
V
L
Q
S
G
Q
N
P
D
P
L
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I
G
E
L
V
A
R
H
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V
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M
L
-
Q
L
S
A
S
----
L
F
N
F
L
--
V
D
-
E
V
P
-----
E
A
-
F
E
----
G
V
R
Y
A
I
T
G
G
E
P
A
S
-
V
P
H
V
A
--
K
-
A
--
R
R
D
H
P
A
L
R
-
L
G
N
G
Y
G
P
A
E
S
M
G
------
F
T
T
H
H
-----
A
V
V
A
G
-----
D
--
L
S
--
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T
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--
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---
G
E
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Y
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A
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A
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L
A
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P
A
L
T
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F
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A
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P
F
A
GP
G
G
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--
R
M
Y
R
T
G
D
L
A
R
R
R
A
D
G
V
L
E
Y
V
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
41.30
37%
-34
- C1 -
4D56
5
?
A:
[30-516]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
I
H
Q
L
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
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Y
L
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T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
S
L
E
M
V
I
G
L
L
A
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L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
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R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
T
Q
T
Q
W
S
N
---
L
I
S
D--
Y
---
Q
---
G
----
Q
------------
V
I
C
L
D
S
Q
W
A
K
I
A
S
Y
S
Q
E
N
L
V
N
----
T
V
------
N
P
----
E
N
L
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
Q
S
L
V
N
-
F
-
T
K
-
L
A
I
A
--
Q
Y
Q
I
T
T
S
D
-
R
T
L
Q
F
V
S
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
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G
A
T
L
I
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M
I
S
S
I
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F
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Q
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D
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W
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S
L
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A
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W
H
L
L
V
N
E
L
--
V
K
-
S
K
I
-----
A
L
-
P
D
----
S
L
R
L
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G
E
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Q
-
P
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L
V
R
--
M
-
W
--
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K
N
V
G
N
F
P
E
L
I
N
V
Y
G
P
T
E
G
T
I
AVSLCR
L
S
Q
L
T
-----
E
-
S
Q
R
-----
N
--
R
T
----
E
I
P
--
I
G
K
S
L
G
E
N
I
S
V
Y
V
L
D
E
T
-
L
K
T
V
-
P
-
P
E
T
P
---
G
E
I
Y
I
G
G
T
A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
I
Q
D
P
F
S
--
P
S
E
--
R
L
Y
K
T
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D
L
G
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Y
L
A
D
G
N
L
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Y
L
G
R
V
D
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Q
V
K
I
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G
F
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V
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G
E
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V
L
L
Q
H
H
Q
V
A
Q
A
---
V
V
I
D
-
R
----------------
R
L
V
--
A
Y
L
V
P
H
S
--
T
E
E
--
N
L
T
V
--
T
---
L
Q
Q
F
L
K
N
K
L
P
S
Y
M
I
P
A
T
F
V
V
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
41.29
37%
-47
- C1 -
4D4H
1
?
A:
[30-436]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
I
H
Q
L
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
T
Q
T
Q
W
S
N
---
L
I
S
D--
Y
---
Q
---
G
----
Q
------------
V
I
C
L
D
S
Q
W
A
K
I
A
S
Y
S
Q
E
N
L
V
N
----
T
V
------
N
P
----
E
N
L
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
Q
S
L
V
N
-
F
-
T
K
-
L
A
I
A
--
Q
Y
Q
I
T
T
S
D
-
R
T
L
Q
F
V
S
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
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G
A
T
L
I
L
R
T
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E
M
I
S
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
V
W
-
S
L
P
T
A
Y
W
H
L
L
V
N
E
L
--
V
K
-
S
K
I
-----
A
L
-
P
D
----
S
L
R
L
V
I
I
G
G
E
R
V
Q
-
P
E
L
V
R
--
M
-
W
--
F
K
N
V
G
N
F
P
E
L
I
N
V
Y
G
P
T
E
G
T
I
AV
S
L
C
R
L
S
Q
L
T
-----
E
-
S
Q
R
-----
N
--
R
T
----
E
I
P
--
I
G
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L
G
E
N
I
S
V
Y
V
L
D
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-
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K
T
V
-
P
-
P
E
T
P
---
G
E
I
Y
I
G
G
T
A
L
A
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G
Y
L
N
R
P
E
L
T
A
Q
K
F
I
Q
D
P
F
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--
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--
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L
Y
K
T
G
D
L
G
R
Y
L
A
D
G
N
L
E
Y
L
G
R
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
41.26
27%
-7
- C1 -
4ZXH
3
?
A:
[98-1182]
------------------------------------------------------------------------------------------------------
D
A
R
H
I
E
A
S
-
D
L
T
Q
L
V
E
----
Q
D
T
K
Q
P
F
D
L
T
-
Q
P
P
---
L
W
R
I
H
C
Y
E
C
G
Q
N
H
Y
V
I
A
F
V
I
H
H
A
L
M
D
F
W
S
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L
L
L
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D
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K
R
F
G
L
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A
E
S
D
A
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N
G
I
E
F
V
Q
Y
A
----
D
K
Q
Q
S
S
V
I
D
---
D
----
T
D
E
S
L
I
F
W
K
N
A
L
K
H
APHV
H
S
I
P
L
D
Y
P
R
P
A
V
Q
Q
H
K
G
S
----
S
L
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F
R
V
S
E
S
V
S
S
-
G
L
V
N
L
A
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D
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Y
E
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L
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G
L
V
L
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G
F
Y
V
L
L
H
K
L
S
N
E
N
N
L
V
I
A
T
P
V
A
G
R
L
E
R
--
S
L
R
N
A
L
G
Q
F
V
N
T
I
A
I
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M
D
I
D
A
D
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T
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R
Q
F
T
Q
Q
V
Q
---
E
Q
L
R
Q
S
L
K
H
QKIA
F
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G
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A
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I
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-----
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L
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-------
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---
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---
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---
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----
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------------
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A
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T
L
A
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------
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------
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R
T
G
D
K
V
C
L
R
T
D
G
R
L
T
H
H
G
R
L
D
F
Q
V
K
I
R
G
F
R
I
E
L
G
E
I
E
N
V
L
K
Q
I
D
G
I
T
D
A
---
V
V
L
V
-
K
T
------
T
---
G
-
D
N
D
Q
K
L
--
V
A
Y
V
--
T
--
G
Q
E
--
L
D
I
A
--
G
---
L
K
K
N
L
Q
I
H
L
P
A
Y
M
V
P
S
A
F
I
R
L
D
E
F
P
M
T
A
N
K
K
L
D
R
K
A
F
P
-
E
P
I
F
E
--
Q
S
N
D
Y
V
A
P
R
D
P
I
E
I
E
L
C
T
T
F
E
Q
I
L
S
V
K
R
V
G
I
H
D
D
F
F
E
L
G
G
H
S
L
L
A
V
K
L
V
N
H
L
K
K
A
-
F
G
T
E
L
S
V
A
L
L
A
Q
Y
S
T
V
E
R
L
G
E
I
I
--
R
E
N
K
E
I
K
P
S
I
V
I
E
L
-
R
R
G
T
Y
E
Q
P
L
W
L
F
H
P
I
G
G
S
T
F
C
Y
M
E
L
S
R
H
L
N
P
N
R
T
L
R
A
I
Q
S
PG
L
I
E
A
----------
D
AAE
V
A
I
E
E
M
A
T
L
Y
I
A
E
M
Q
K
M
Q
P
Q
G
P
Y
F
L
G
G
W
C
F
G
G
A
I
A
Y
E
I
S
R
Q
L
R
Q
M
G
Q
Q
V
T
G
I
V
M
I
D
T
---
R
A
P
I
P
E
N
----------
V
---
P
E
-----
D
----
A
----
D
-------
D
A
M
L
------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
40.93
37%
-34
- C1 -
4D4I
4
?
A:
[30-515]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
I
H
Q
L
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
T
Q
T
Q
W
S
N
---
L
I
S
D--
Y
---
Q
---
G
----
Q
------------
V
I
C
L
D
S
Q
W
A
K
I
A
S
Y
S
Q
E
N
L
V
N
----
T
V
------
N
P
----
E
N
L
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
Q
S
L
V
N
-
F
-
T
K
-
L
A
I
A
--
Q
Y
Q
I
T
T
S
D
-
R
T
L
Q
F
V
S
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
S
G
A
T
L
I
L
R
T
E
E
M
I
S
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
V
W
-
S
L
P
T
A
Y
W
H
L
L
V
N
E
L
--
V
K
-
S
K
I
-----
A
L
-
P
D
----
S
L
R
L
V
I
I
G
G
E
R
V
Q
-
P
E
L
V
R
--
M
-
W
--
F
K
N
V
G
N
F
P
E
L
I
N
V
Y
G
P
T
E
G
T
I
AV
S
L
C
R
L
S
Q
L
T
-----
E
-
S
Q
R
-----
N
--
R
T
----
E
I
P
--
I
G
K
S
L
G
E
N
I
S
V
Y
V
L
D
E
T
-
L
K
T
V
-
P
-
P
E
T
P
---
G
E
I
Y
I
G
G
T
A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
I
Q
D
P
F
S
--
P
S
E
--
R
L
Y
K
T
G
D
L
G
R
Y
L
A
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
---
V
V
I
D
-
R
----------------
R
L
V
--
A
Y
L
V
P
H
S
--
T
E
E
--
N
L
T
V
--
T
---
L
Q
Q
F
L
K
N
K
L
P
S
Y
M
I
P
A
T
F
V
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
40.57
37%
-34
- C1 -
4D57
5
?
A:
[30-516]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
I
H
Q
L
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
T
Q
T
Q
W
S
N
---
L
I
S
D--
Y
---
Q
---
G
----
Q
------------
V
I
C
L
D
S
Q
W
A
K
I
A
S
Y
S
Q
E
N
L
V
N
----
T
V
------
N
P
----
E
N
L
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
Q
S
L
V
N
-
F
-
T
K
-
L
A
I
A
--
Q
Y
Q
I
T
T
S
D
-
R
T
L
Q
F
V
S
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
S
G
A
T
L
I
L
R
T
E
E
M
I
S
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
V
W
-
S
L
P
T
A
Y
W
H
L
L
V
N
E
L
--
V
K
-
S
K
I
-----
A
L
-
P
D
----
S
L
R
L
V
I
I
G
G
E
R
V
Q
-
P
E
L
V
R
--
M
-
W
--
F
K
N
V
G
N
F
P
E
L
I
N
V
Y
G
P
T
E
G
T
I
AVSLCR
L
S
Q
L
T
-----
E
-
S
Q
R
-----
N
--
R
T
----
E
I
P
--
I
G
K
S
L
G
E
N
I
S
V
Y
V
L
D
E
T
-
L
K
T
V
-
P
-
P
E
T
P
---
G
E
I
Y
I
G
G
T
A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
I
Q
D
P
F
S
--
P
S
E
--
R
L
Y
K
T
G
D
L
G
R
Y
L
A
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
---
V
V
I
D
-
R
----------------
R
L
V
--
A
Y
L
V
P
H
S
--
T
E
E
--
N
L
T
V
--
T
---
L
Q
Q
F
L
K
N
K
L
P
S
Y
M
I
P
A
T
F
V
V
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
40.56
37%
-31
- C1 -
4D4G
4
?
A:
[30-514]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
I
H
Q
L
F
E
T
Q
V
E
R
T
P
E
A
V
A
V
L
S
E
Q
G
Q
L
T
Y
E
E
L
N
T
K
A
N
Q
L
A
H
Y
L
R
T
L
G
V
K
S
E
T
L
V
G
V
C
V
D
R
S
L
E
M
V
I
G
L
L
A
I
L
K
A
G
G
A
Y
V
P
L
D
P
T
Y
P
R
E
R
L
T
Y
M
V
Q
D
A
Q
I
S
V
L
V
T
Q
T
Q
W
S
N
---
L
I
S
D--
Y
---
Q
---
G
----
Q
------------
V
I
C
L
D
S
Q
W
A
K
I
A
S
Y
S
Q
E
N
L
V
N
----
T
V
------
N
P
----
E
N
L
A
Y
V
I
Y
T
S
G
S
T
G
K
P
K
G
V
M
I
E
H
Q
S
L
V
N
-
F
-
T
K
-
L
A
I
A
--
Q
Y
Q
I
T
T
S
D
-
R
T
L
Q
F
V
S
I
S
F
D
V
A
A
E
E
I
Y
V
T
L
C
S
G
A
T
L
I
L
R
T
E
E
M
I
S
S
I
P
S
F
V
Q
K
S
Q
D
W
Q
I
T
V
W
-
S
L
P
T
A
Y
W
H
L
L
V
N
E
L
--
V
K
-
S
K
I
-----
A
L
-
P
D
----
S
L
R
L
V
I
I
G
G
E
R
V
Q
-
P
E
L
V
R
--
M
-
W
--
F
K
N
V
G
N
F
P
E
L
I
N
V
Y
G
P
T
E
G
T
I
AVSLCR
L
S
Q
L
T
-----
E
-
S
Q
R
-----
N
--
R
T
----
E
I
P
--
I
G
K
S
L
G
E
N
I
S
V
Y
V
L
D
E
T
-
L
K
T
V
-
P
-
P
E
T
P
---
G
E
I
Y
I
G
G
T
A
L
A
R
G
Y
L
N
R
P
E
L
T
A
Q
K
F
I
Q
D
P
F
S
--
P
S
E
--
R
L
Y
K
T
G
D
L
G
R
Y
L
A
D
G
N
L
E
Y
L
G
R
V
D
H
Q
V
K
I
N
G
F
R
V
E
L
G
E
I
E
T
V
L
L
Q
H
H
Q
V
A
Q
A
---
V
V
I
D
-
R
----------------
R
L
V
--
A
Y
L
V
P
H
S
--
T
E
E
--
N
L
T
V
--
T
---
L
Q
Q
F
L
K
N
K
L
P
S
Y
M
I
P
A
T
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
40.14
31%
-21
- C1 -
4DG9
1
?
A:
[18-562]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
---
L
D
L
Y
A
H
P
T
V
V
A
R
F
S
E
M
A
A
L
H
P
H
R
E
A
I
R
D
R
F
G
S
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
Y
L
L
E
H
Y
P
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
C
R
L
I
L
------------
D
---
C
---
S
---
T
----
T
------------
P
T
P
A
N
G
L
-----
P
C
V
P
V
R
H
L
P
A
-
A
P
A
S
V
A
R
PCF
A
A
----
D
Q
I
A
Y
I
N
F
S
S
G
T
T
G
R
P
K
A
I
A
C
T
H
A
G
I
T
R
-
L
-
C
L
-
G
Q
-
S
--
F
L
A
F
A
P
Q
M
-
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
I
W
G
A
L
L
N
G
G
C
C
-
V
L
N
D
L
G
P
L
D
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
-
W
L
T
A
S
----
L
F
N
T
L
--
V
D
-
L
D
P
-----
D
C
-
L
G
----
G
L
R
Q
L
L
T
G
G
D
I
L
S
V
P
H
V
R
R
--
A
L
L
--
R
H
--
P
R
L
H
-
L
V
N
G
Y
G
P
T
E
N
T
T
------
F
T
C
C
H
-----
V
-
V
T
D
-----
D
D
L
E
E
--
D
-
D
I
P
--
I
G
K
A
I
A
-
G
T
A
V
L
L
L
D
E
H
-
G
Q
---
E
-
I
A
E
P
D
R
A
G
E
I
V
A
F
G
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
R
A
S
F
V
E
L
P
Y
R
---
G
R
L
L
R
A
Y
R
T
G
D
R
A
R
Y
D
E
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
C
---
A
L
L
V
-
R
E
------
R
---
N
-
G
V
K
Q
L
L
--
C
A
W
T
--
G
-------
K
A
D
A
--
S
---
P
Q
A
-
L
L
R
Q
L
P
T
W
Q
R
P
H
A
C
V
R
V
E
A
L
P
L
T
A
H
G
K
L
D
R
A
A
L
L
-
R
R
L
E
---------
L
D
P
D
--
Q
R
G
C
A
Q
L
W
S
E
L
L
G
C
E
V
G
A
---
D
F
F
L
C
G
G
N
S
L
L
A
L
Q
L
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
HHSearch
39.69
40%
-17
- C1 -
1AMU
4
GRSA_ANEMI
A:
[35-530]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
P
R
D
K
T
I
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
T
Q
K
H
L
V
H
---
L
I
H
---
N
---
I
QFN
G
----
Q
------------
V
E
I
F
E
E
D
-----
T
I
K
I
R
E
G
T
N
L
-
H
V
P
S
------
K
S
----
T
D
L
A
Y
V
I
Y
T
S
-----
P
K
G
T
M
L
E
H
K
G
I
S
N
-
L
-
K
V
-
F
F
-
E
--
N
S
L
N
V
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
I
-
T
L
P
P
T
----
Y
V
V
H
L
--
D
P
---------
E
R
-
I
L
----
S
I
Q
T
L
I
T
A
G
S
A
T
S
-
P
S
L
V
N
--
K
-
W
--
K
E
---
K
V
T
-
Y
I
N
A
Y
G
P
T
E
T
T
I
------
C
A
T
T
W
-----
V
-
A
T
K
E
----
T
--
I
G
--
H
-
S
V
P
--
I
G
A
P
I
Q
-
N
T
Q
I
Y
I
V
D
E
N
-
L
Q
L
K
-
S
-
V
G
E
A
---
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
V
D
N
P
F
V
--
P
G
E
--
K
L
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
---
A
V
S
V
-
H
K
------
D
---
H
Q
E
Q
P
Y
L
C
--
A
Y
F
V
--
S
--
E
K
H
--
I
P
L
E
--
Q
---
L
R
Q
F
S
S
E
E
L
P
T
Y
M
I
P
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
-
E
P
D
L
T
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
38.69
31%
-23
- C1 -
4DG8
3
?
A:
[17-515]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
S
L
---
L
D
L
Y
A
H
P
T
V
V
A
R
F
S
E
M
A
A
L
H
P
H
R
E
A
I
R
D
R
F
G
S
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
Y
L
L
E
H
Y
P
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
C
R
L
I
L
------------
D
---
C
---
S
---
T
----
T
------------
P
T
P
A
N
G
L
-----
P
C
V
P
V
R
H
L
P
A
-
A
P
A
S
VA
R
P
C
F
A
A
----
D
Q
I
A
Y
I
N
F
S
S
G
T
T
G
R
P
K
A
I
A
C
T
H
A
G
I
T
R
-
L
-
C
L
-
G
Q
-
S
--
F
L
A
F
A
P
Q
M
-
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
I
W
G
A
L
L
N
G
G
C
C
-
V
L
N
D
L
G
P
L
D
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
-
W
L
T
A
S
----
L
F
N
T
L
--
V
D
-
L
D
P
-----
D
C
-
L
G
----
G
L
R
Q
L
L
T
G
G
D
I
L
S
V
P
H
V
R
R
--
A
L
L
--
R
H
--
P
R
L
H
-
L
V
N
G
Y
G
P
T
E
N
T
T
------
F
T
C
C
H
-----
V
-
V
T
D
-----
D
D
L
E
E
--
D
-
D
I
P
--
I
G
K
A
I
A
-
G
T
A
V
L
L
L
D
E
H
-
G
Q
---
E
-
I
A
E
P
D
R
A
G
E
I
V
A
F
G
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
R
A
S
F
V
E
L
P
Y
R
---
G
R
L
L
R
A
Y
R
T
G
D
R
A
R
Y
D
E
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
C
---
A
L
L
V
-
R
E
------
R
---
N
-
G
V
K
Q
L
L
--
C
A
W
T
--
G
-------
K
A
D
A
--
S
---
P
Q
A
-
L
L
R
Q
L
P
T
W
Q
R
P
H
A
C
V
R
V
E
A
L
P
L
T
----
L
D
R
A
A
L
L
-
R
R
L
E
E
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
37.44
40%
-50
- C1 -
5ES7
2
LGRA_BREPA
A:
[196-585]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
G
E
K
P
I
D
K
T
F
H
Q
L
F
E
Q
Q
V
E
M
T
P
D
H
V
A
V
V
D
R
G
Q
S
L
T
Y
K
Q
L
N
E
R
A
N
Q
L
A
H
H
L
R
G
K
G
V
K
P
D
D
Q
V
A
I
M
L
D
K
S
L
D
M
I
V
S
I
L
A
V
M
K
A
G
G
A
Y
V
P
I
D
P
D
Y
P
G
E
R
I
A
Y
M
L
A
D
S
S
A
A
I
L
L
T
N
A
L
H
E
E
---
K
A
--------
N
---
G
----
A
------------
C
D
I
I
D
V
H
DP---
D
S
Y
S
E
N
T
N
N
L
-
P
H
V
N
------
R
P
----
D
D
L
V
Y
V
M
Y
T
S
-----
A
K
G
V
M
I
E
H
H
N
L
V
N
-
F
-
C
E
W
Y
R
-
P
--
Y
F
G
V
T
P
A
D
-
K
A
L
V
Y
S
S
F
S
F
D
G
S
A
L
D
I
F
T
H
L
L
A
G
A
A
L
H
I
V
P
S
E
R
K
Y
D
L
D
A
L
N
D
Y
C
N
Q
E
G
I
T
I
S
-
Y
L
P
T
G
----
A
A
E
Q
F
--
M
Q
-
M
D
N
-----
Q
S
-
F
R
-------
V
V
I
T
G
G
D
V
L
K
-
K
I
E
R
N
--
G
-
T
--------
Y
K
-
L
Y
N
G
Y
G
P
T
E
C
T
I
------
M
V
T
M
F
-----
E
-
V
D
K
-----
P
--
Y
A
--
N
--
I
P
--
I
G
K
P
I
D
-
R
T
R
I
L
I
L
D
E
A
-
L
A
L
Q
-
P
-
I
G
V
A
---
G
E
L
F
I
V
G
E
G
L
G
R
G
Y
L
N
R
P
E
L
T
A
E
K
F
I
V
H
P
-
Q
--
T
G
E
--
R
M
Y
R
T
G
D
R
A
R
F
L
P
D
G
N
I
E
F
L
G
R
L
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
36.69
30%
-37
- C1 -
4DG8
3
?
A:
[25-515]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
H
P
T
V
V
A
R
F
S
E
M
A
A
L
H
P
H
R
E
A
I
R
D
R
F
G
S
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
Y
L
L
E
H
Y
P
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
C
R
L
I
L
D
C
S
T
T
P
T
---
P
A
N
---
G
-------
L
----
P
------------
C
V
P
V
R
H
-------
L
P
A
A
P
A
S
V
A
-
R
P
C
F
------
A
A
----
D
Q
I
A
Y
I
N
F
S
S
G
T
T
G
R
P
K
A
I
A
C
T
H
A
G
I
T
R
-
L
-
C
L
-
G
Q
----
S
F
L
A
F
A
P
Q
M
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
I
W
G
A
L
L
N
G
G
C
C
V
L
N
D
L
G
-
P
L
D
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
-
W
L
T
A
S
----
L
F
N
T
L
--
V
D
-
L
D
P
-----
D
C
-
L
G
----
G
L
R
Q
L
L
T
G
G
D
I
L
S
-
V
P
H
V
R
--
R
-
A
--
L
L
R
H
P
R
L
H
-
L
V
N
G
Y
G
P
T
E
N
T
T
------
F
T
C
C
H
-----
V
-
V
T
D
D
D
---
L
--
E
E
--
D
-
D
I
P
--
I
G
K
A
I
A
-
G
T
A
V
L
L
L
D
E
H
-
G
Q
E
I
A
E
-
P
D
R
A
---
G
E
I
V
A
F
G
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
R
A
S
F
V
E
L
P
Y
R
G-
R
L
L
--
R
A
Y
R
T
G
D
R
A
R
Y
D
E
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
C
---
A
L
L
V
-
R
E
------
R
---
N
-
G
V
K
Q
L
L
--
C
A
W
T
--
G
--
K
------
A
D
--
A
---
S
P
Q
A
L
L
R
Q
L
P
T
W
Q
R
P
H
A
C
V
R
V
E
A
L
P
L
T
----
L
D
R
A
A
L
L
-
R
R
L
E
E
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
36.42
34%
-30
- C1 -
3VNS
2
?
A:
[33-533]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
S
D
L
V
S
L
F
R
E
V
A
A
T
A
P
E
R
T
A
L
S
A
E
D
D
R
I
S
Y
G
R
L
D
A
W
S
D
A
V
A
R
T
L
L
A
E
G
V
R
P
G
D
R
V
A
L
R
M
S
P
G
A
E
A
I
V
A
I
L
A
I
L
K
C
G
A
A
Y
V
P
V
D
L
R
N
P
V
S
R
S
D
F
I
L
A
D
S
G
A
S
A
L
I
G
----
E
P
---
H
E
G
---
C
---
A
---
V
----
T
------------
R
V
V
R
T
A
A
-----
V
A
E
C
K
D
A
E
P
------------
A
P
GPGA
E
D
M
A
Y
V
I
Y
T
S
G
-
T
G
N
P
K
G
V
P
V
R
H
A
N
V
L
A
-
L
-
L
A
-
G
A
P
S
--
V
F
D
F
S
G
D
D
-
R
W
L
L
F
H
S
L
S
F
D
F
S
V
W
E
I
W
G
A
F
S
T
G
A
E
L
V
V
L
P
H
W
A
A
R
T
P
E
Q
Y
L
A
V
I
I
D
R
G
V
T
V
I
-
N
Q
T
P
T
----
A
F
L
A
L
T
E
A
A
-
V
R
G
-----
G
R
D
V
S
----
G
L
R
Y
V
I
F
G
G
E
K
L
T
-
A
P
M
L
R
P
W
A
-
K
--
A
F
G
L
D
R
P
R
-
L
V
N
G
Y
G
I
T
E
T
T
V
------
F
T
T
F
E
-----
E
-
I
T
E
-----
A
--
Y
L
--
A
-
Q
D
A
SI
I
G
R
A
L
P
-
S
F
G
T
R
V
V
G
D
D
-
G
R
D
V
-
A
-
P
G
E
T
---
G
E
L
W
L
S
G
A
Q
L
A
E
G
Y
L
R
R
P
E
L
T
A
E
K
F
---
P
E
V
-----V-
R
Y
Y
R
T
G
D
L
V
S
E
L
P
D
G
R
F
A
Y
E
G
R
A
D
L
Q
I
K
L
R
G
Y
R
I
E
L
S
D
I
E
T
A
V
R
R
H
D
D
V
V
D
A
---
V
V
T
V
-
R
E
F
-----
K
---
P
-
G
D
L
R
L
V
--
C
A
Y
V
--
A
--
R
E
G
--
S
A
T
T
A
R
E
---
L
R
N
H
I
K
T
L
L
P
A
Y
M
H
P
A
R
Y
L
P
L
P
G
L
P
R
T
V
N
G
K
V
D
R
A
A
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
34.68
34%
-30
- C1 -
3VNQ
1
?
A:
[33-533]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
S
D
L
V
S
L
F
R
E
V
A
A
T
A
P
E
R
T
A
L
S
A
E
D
D
R
I
S
Y
G
R
L
D
A
W
S
D
A
V
A
R
T
L
L
A
E
G
V
R
P
G
D
R
V
A
L
R
M
S
P
G
A
E
A
I
V
A
I
L
A
I
L
K
C
G
A
A
Y
V
P
V
D
L
R
N
P
V
S
R
S
D
F
I
L
A
D
S
G
A
S
A
L
I
G
----
E
P
---
H
E
G
---
C
---
A
---
V
----
T
------------
R
V
V
R
T
A
A
-----
V
A
E
C
K
D
A
E
-------------
A
P
GPGA
E
D
M
A
Y
V
I
Y
T
S
G
T
T
G
N
P
K
G
V
P
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