@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu19740: (2016-07-01 )
MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCNIGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSEAIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERYPAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPPPGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAPIAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGAVLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRGLIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD
Atome Classification :
(29 SA)
.........10........20........30........40........50........60......-..-70-......-..80........90........100.......110.......120.......130.......140.......150..--.....160.......170...-...-..180.......190.......200.......210.......220.......230.......240.......250...-.-...260.......270.-......280.......290---..---..---....300.......310.......320......-.330........340.......350.......360.......370.-------.....-----------------.380.......390.......400.......410.......420.......430.......440..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSS
Y
L
IKPELSSAYP
V
V
S
YAKG
S
Y
V
YDQTGKKYLDGSS
G
A
V
T
C
NIGH
G
V
R
D
V
T
E
K
L
K
E
Q
L
D
Q
V
S
F
A
Y
-
R
S
-QF-TS
E
P
A
E
-
Q
L
A
A
L
L
A
Q
ELPGDV
N
W
S
F
F
VNSG
S
E
A
I
E
T
A
M
K
I
A
I
Q
Y
W
Q
E
K
K
Q
T
Q
K
S
I
F
L
S
R
WSSYH
G
I
T
L
G
A
L
S
L
S
G
F
Y
E
R
R
Y
R
F
T
--
H
L
I
E
RYPAISA
P
H
I
Y
RL-NHE-
T
E
E
-
D
F
V
Q
T
A
A
D
E
L
D
T
M
I
K
R
I
G
S
Q
F
I
A
G
F
V
AE
P
I
IGAAGAAITPP
P
G
Y
Y
E
R
L
S
E
V
C
R
TH
D
V
L
F
I
A
D
E
V
M
T
G
LGRTG
R
M
L
A
TE-H-WDTVP
D
I
A
V
L
G
KGLGA
G
-
Y
A
P
I
A
A
A
V
V
S
D
S
I
I
E
T
I
K
----QG---S
G
---
V
I
MSGHTYSAHPY
S
A
K
A
A
L
E
V
L
R
Y
V
L
KH
G
L
IKQ-SE-KK
G
A
V
L
K
K
K
L
D
E
A
A
S
QSG
I
I
G
EVRG
K
G
L
L
L
G
I
E
F
VADQKTKKV-------F
P
P
E
Q
-----------------
A
I
T
Q
L
I
V
S
E
A
KKR
G
L
I
V
YPSKAGIDSGEG
D
A
V
I
I
APPFTISD
G
E
M
E
E
L
I
S
I
F
S
E
T
V
A
A
V
E
K
N
LKKD
10
PsiBlast_PDB
80.91
29%
-59
- C1 -
3I5T
2
?
A:
[35-454]
-----------
S
A
Q
P
V
L
T
H
A
E
G
I
Y
V
H
T
E
D
G
R
R
L
I
D
G
P
A
G
M
W
C
A
Q
V
G
Y
G
R
R
E
I
V
D
A
M
A
H
Q
A
M
V
L
P
Y
A
S
-
P
W
-
Y
M
-
A
T
S
P
A
A
-
R
L
A
E
K
I
A
T
L
T
P
G
D
L
N
R
I
F
F
T
T
G
G
S
T
A
V
D
S
A
L
R
F
S
E
F
Y
N
N
V
L
G
R
P
Q
K
K
R
I
I
V
R
Y
D
G
Y
H
G
S
T
A
L
T
A
A
C
T
G
R
T
G
N
W
P
N
F
D
--
I
A
Q
D
R
I
S
F
L
S
S
P
N
P
R
H
A
-
G
N
R
-
S
Q
E
-
A
F
L
D
D
L
V
Q
E
F
E
D
R
I
E
S
L
G
P
D
T
I
A
A
F
L
A
E
P
I
L
-
A
S
G
G
V
I
I
P
P
A
G
Y
H
A
R
F
K
A
I
C
E
K
H
D
I
L
Y
I
S
D
E
V
V
T
G
F
G
R
C
G
E
W
F
A
S
E
-
K
V
F
G
V
V
P
D
I
I
T
F
A
K
G
V
T
S
G
-
Y
V
P
L
G
G
L
A
I
S
E
A
V
L
A
R
I
S
GENA
K
G
---
S
----
W
F
T
N
G
Y
T
Y
S
N
Q
P
V
A
C
A
A
A
L
A
N
I
E
L
M
E
R
E
G
I
V
D
Q
-
A
R
-
E
M
A
D
Y
F
A
A
A
L
A
S
L
R
D
L
P
G
-
V
A
E
T
R
S
V
G
L
V
G
C
V
Q
C
L
L
D
-----
G
-------
T
A
E
D
K
-----------------
A
F
T
L
K
I
D
E
R
C
F
E
L
G
L
I
V
R
P
L
--------
G
D
L
C
V
I
S
P
P
L
I
I
S
R
A
Q
I
D
E
M
V
A
I
M
R
Q
A
I
T
E
V
-------
70
HHSearch
80.70
29%
-52
- C1 -
3I5T
2
?
A:
[36-457]
------------
A
Q
P
V
L
T
H
A
E
G
I
Y
V
H
T
E
D
G
R
R
L
I
D
G
P
A
G
M
W
C
A
Q
V
G
Y
G
R
R
E
I
V
D
A
M
A
H
Q
A
M
V
L
P
Y
A
S
-
P
W
-
Y
M
-
A
T
S
P
A
A
-
R
L
A
E
K
I
A
T
L
T
P
G
D
L
N
R
I
F
F
T
T
G
G
S
T
A
V
D
S
A
L
R
F
S
E
F
Y
N
N
V
L
G
R
P
Q
K
K
R
I
I
V
R
Y
D
G
Y
H
G
S
T
A
L
T
A
A
C
T
G
R
T
G
N
W
P
N
F
D
--
I
A
Q
D
R
I
S
F
L
S
S
P
N
P
R
H
A
-
G
N
R
-
S
Q
E
-
A
F
L
D
D
L
V
Q
E
F
E
D
R
I
E
S
L
G
P
D
T
I
A
A
F
L
A
E
P
I
L
A
S
-
G
G
V
I
I
P
P
A
G
Y
H
A
R
F
K
A
I
C
E
K
H
D
I
L
Y
I
S
D
E
V
V
T
G
F
G
R
C
G
E
W
F
A
S
E
K
V
-
F
G
V
V
P
D
I
I
T
F
A
K
G
V
T
S
G
Y
V
-
P
L
G
G
L
A
I
S
E
A
V
L
A
R
I
S
----
G
E
NAK
G
S
---
W
F
T
N
G
Y
T
Y
S
N
Q
P
V
A
C
A
A
A
L
A
N
I
E
L
M
E
R
E
G
I
V
D
Q
-
A
R
-
E
M
A
D
Y
F
A
A
A
L
A
S
L
R
D
-
L
P
G
V
A
E
T
R
S
V
G
L
V
G
C
V
Q
C
L
L
D
-----
G
-------
T
A
E
D
K
-----------------
A
F
T
L
K
I
D
E
R
C
F
E
L
G
L
I
V
R
--
P
L
G
------
D
L
C
V
I
S
P
P
L
I
I
S
R
A
Q
I
D
E
M
V
A
I
M
R
Q
A
I
T
E
V
S
A
A
----
32
PsiBlast_CBE
78.98
31%
-19
- C1 -
4A6T
2
?
C:
[35-454]
---------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
-
Y
-
N
T
-
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
H
E
Q
G
D
--
L
P
I
P
G
M
A
H
I
E
Q
P
W
W
Y
K
H
-
G
K
D
M
T
P
D
-
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
-
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
-
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
-
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
----
A
G
----
G
---
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
-
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
-------
F
P
D
F
G
-----------------
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
K
--
27
PsiBlast_CBE
78.87
31%
-19
- C1 -
4AH3
2
?
C:
[35-454]
---------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
-
Y
-
N
T
-
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
H
E
Q
G
D
--
L
P
I
P
G
M
A
H
I
E
Q
P
W
W
Y
K
H
-
G
K
D
M
T
P
D
-
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
-
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
-
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
-
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
----
A
G
----
G
---
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
-
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
-------
F
P
D
F
G
-----------------
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
K
--
31
PsiBlast_CBE
78.43
31%
-19
- C1 -
4A6T
2
?
D:
[35-454]
---------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
-
Y
-
N
T
-
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
H
E
Q
G
D
--
L
P
I
P
G
M
A
H
I
E
Q
P
W
W
Y
K
H
-
G
K
D
M
T
P
D
-
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
-
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
-
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
-
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
----
A
G
----
G
---
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
-
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
-------
F
P
D
F
G
-----------------
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
K
--
29
PsiBlast_CBE
78.35
31%
-19
- C1 -
4A72
2
?
D:
[35-454]
---------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
-
Y
-
N
T
-
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
H
E
Q
G
D
--
L
P
I
P
G
M
A
H
I
E
Q
P
W
W
Y
K
H
-
G
K
D
M
T
P
D
-
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
-
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
-
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
-
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
----
A
G
----
G
---
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
-
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
-------
F
P
D
F
G
-----------------
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
K
--
6
PsiBlast_PDB
78.25
31%
-18
- C1 -
4AH3
2
?
A:
[35-454]
---------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
-
Y
-
N
T
-
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
H
E
Q
G
D
--
L
P
I
P
G
M
A
H
I
E
Q
P
W
W
Y
K
H
-
G
K
D
M
T
P
D
-
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
-
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
-
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
-
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
----
A
G
----
G
---
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
-
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
-------
F
P
D
F
G
-----------------
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
K
--
8
PsiBlast_PDB
78.17
31%
-19
- C1 -
4BA5
1
?
A:
[35-454]
---------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
-
Y
-
N
T
-
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
H
E
Q
G
D
--
L
P
I
P
G
M
A
H
I
E
Q
P
W
W
Y
K
H
-
G
K
D
M
T
P
D
-
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
-
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
-
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
-
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
----
A
G
----
G
---
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
-
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
-------
F
P
D
F
G
-----------------
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
K
--
33
PsiBlast_CBE
78.02
31%
-18
- C1 -
4A6T
2
?
B:
[35-454]
---------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
-
Y
-
N
T
-
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
H
E
Q
G
D
--
L
P
I
P
G
M
A
H
I
E
Q
P
W
W
Y
K
H
-
G
K
D
M
T
P
D
-
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
-
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
-
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
-
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
----
A
G
----
G
---
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
-
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
-------
F
P
D
F
G
-----------------
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
K
--
3
PsiBlast_PDB
77.56
31%
-21
- C1 -
4A6R
2
?
A:
[35-454]
---------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
-
Y
-
N
T
-
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
H
---
D
--
L
P
I
P
G
M
A
H
I
E
Q
P
W
W
Y
K
H
-
G
K
D
M
T
P
D
-
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
-
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
-
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
-
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
----
A
G
----
G
---
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
-
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
-------
F
P
D
F
G
-----------------
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
K
--
7
PsiBlast_PDB
77.48
31%
-22
- C1 -
4BA4
-
?
A:
[35-454]
---------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
-
Y
-
N
T
-
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
H
E
Q
G
D
--
L
P
I
P
G
M
A
H
I
E
Q
P
W
W
Y
K
H
-
G
K
D
M
T
P
D
-
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
-
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
-
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
-
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
----
A
G
----
G
---
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
-
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
-------
F
P
D
F
G
-----------------
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
K
--
24
PsiBlast_CBE
77.43
31%
-17
- C1 -
4BA5
2
?
B:
[35-454]
---------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
-
Y
-
N
T
-
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
H
E
Q
G
D
--
L
P
I
P
G
M
A
H
I
E
Q
P
W
W
Y
K
H
-
G
K
D
M
T
P
D
-
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
-
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
-
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
-
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
----
A
G
----
G
---
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
-
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
-------
F
P
D
F
G
-----------------
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
K
--
4
PsiBlast_PDB
77.24
31%
-17
- C1 -
4A6T
2
?
A:
[35-454]
---------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
-
Y
-
N
T
-
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
H
E
Q
G
D
--
L
P
I
P
G
M
A
H
I
E
Q
P
W
W
Y
K
H
-
G
K
D
M
T
P
D
-
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
-
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
-
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
-
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
----
A
G
----
G
---
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
-
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
-------
F
P
D
F
G
-----------------
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
K
--
28
PsiBlast_CBE
77.03
31%
-20
- C1 -
4AH3
2
?
B:
[35-454]
---------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
-
Y
-
N
T
-
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
H
E
Q
G
D
--
L
P
I
P
G
M
A
H
I
E
Q
P
W
W
Y
K
H
-
G
K
D
M
T
P
D
-
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
-
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
-
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
-
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
----
A
G
----
G
---
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
-
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
-------
F
P
D
F
G
-----------------
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
K
--
25
PsiBlast_CBE
76.98
31%
-22
- C1 -
4BA4
1
?
B:
[35-454]
---------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
-
Y
-
N
T
-
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
H
E
Q
G
D
--
L
P
I
P
G
M
A
H
I
E
Q
P
W
W
Y
K
H
-
G
K
D
M
T
P
D
-
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
-
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
-
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
-
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
----
A
G
----
G
---
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
-
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
-------
F
P
D
F
G
-----------------
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
K
--
26
PsiBlast_CBE
76.67
31%
-18
- C1 -
4AH3
2
?
D:
[35-454]
---------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
-
Y
-
N
T
-
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
H
E
Q
G
D
--
L
P
I
P
G
M
A
H
I
E
Q
P
W
W
Y
K
H
-
G
K
D
M
T
P
D
-
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
-
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
-
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
-
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
----
A
G
----
G
---
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
-
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
-------
F
P
D
F
G
-----------------
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
K
--
34
PsiBlast_CBE
76.41
31%
-22
- C1 -
4A6R
2
?
B:
[35-454]
---------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
-
Y
-
N
T
-
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
H
------
L
P
I
P
G
M
A
H
I
E
Q
P
W
W
Y
K
H
-
G
K
D
M
T
P
D
-
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
-
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
-
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
-
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
----
A
G
----
G
---
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
-
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
-------
F
P
D
F
G
-----------------
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
K
--
30
PsiBlast_CBE
76.02
31%
-19
- C1 -
4A72
2
?
C:
[35-454]
---------------
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
-
Y
-
N
T
-
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
H
E
Q
-
D
--
L
P
I
P
G
M
A
H
I
E
Q
P
W
W
Y
K
H
-
G
K
D
M
T
P
D
-
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
G
G
V
-
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
-
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
-
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
----
A
G
----
G
---
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
-
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
-------
F
P
D
F
G
-----------------
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
A
C
--------
G
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
K
--
77
HHSearch
75.80
30%
-23
- C1 -
4A6R
2
?
A:
[34-453]
--------------
R
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
Y
N
-
T
F
F
K
T
-
T
H
P
A
V
V
-
E
L
S
S
L
L
A
E
V
T
P
A
G
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
H
---
D
--
L
P
I
P
G
M
A
H
I
E
Q
P
W
W
Y
K
H
-
G
K
D
M
T
P
D
-
E
F
G
V
V
A
A
R
W
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
Q
G
A
-
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
-
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
-
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
----
A
G
----
G
---
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
-
V
K
D
D
I
G
P
Y
M
Q
K
R
W
R
E
T
F
S
R
F
E
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
L
-------
F
P
D
F
G
-----------------
E
I
G
T
L
C
R
D
I
F
F
R
N
N
L
I
M
R
--
A
C
G
------
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
---
9
PsiBlast_PDB
75.65
34%
-30
- C1 -
3N5M
6
?
A:
[25-442]
------
R
P
F
S
P
N
S
T
T
V
G
A
K
A
E
G
C
W
V
E
D
I
Q
G
K
R
Y
L
D
G
M
S
G
L
W
C
V
N
S
G
Y
G
R
K
E
L
A
E
A
A
Y
K
Q
L
Q
T
L
S
Y
F
P
-
M
S
-
Q
--
S
H
E
P
A
I
-
K
L
A
E
K
L
N
E
W
L
G
G
E
Y
-
V
I
F
F
S
N
S
G
S
E
A
N
E
T
A
F
K
I
A
R
Q
Y
Y
A
Q
K
G
E
P
H
R
Y
K
F
M
S
R
Y
R
G
Y
H
G
N
T
M
A
T
M
A
A
T
G
Q
A
Q
R
R
Y
Q
Y
E
--
P
F
A
S
G
F
L
H
V
T
P
P
D
C
Y
R
M
P
G
I
E
-
R
E
N
-
I
Y
D
V
E
C
V
K
E
V
D
R
V
M
T
W
E
L
S
E
T
I
A
A
F
I
M
E
P
I
I
-
T
G
G
G
I
L
M
A
P
Q
D
Y
M
K
A
V
H
E
T
C
Q
K
H
G
A
L
L
I
S
D
E
V
I
C
G
F
G
R
T
G
K
A
F
G
F
M
-
N
-
Y
D
V
K
P
D
I
I
T
M
A
K
G
I
T
S
A
-
Y
L
P
L
S
A
T
A
V
K
R
E
I
Y
E
A
F
K
-----
G
---
K
G
EYE
F
F
R
H
I
N
T
F
G
G
N
P
A
A
C
A
L
A
L
K
N
L
E
I
I
E
N
E
N
L
I
E
R
-
S
A
-
Q
M
G
S
L
L
L
E
Q
L
K
E
E
I
G
E
H
P
L
V
G
D
I
R
G
K
G
L
L
V
G
I
E
L
V
N
D
K
E
T
K
E
---------
P
I
D
N
-----------------
D
K
I
A
S
V
V
N
A
C
K
E
K
G
L
I
I
-
G
R
N
G
M
T
T
A
G
Y
N
N
I
L
T
L
A
P
P
L
V
I
S
S
E
E
I
A
F
V
I
-----------------
83
HHSearch
68.14
31%
-18
- C1 -
4PPM
3
?
A:
[414-852]
-----------
R
C
D
N
V
F
R
S
A
A
G
T
Q
L
Y
D
D
A
G
E
A
F
L
D
M
V
A
G
Y
G
C
L
N
L
G
H
N
P
Q
P
V
V
N
A
L
K
N
Y
L
D
A
Q
G
P
N
F
I
Q
Y
-
I
S
-
I
P
E
Q
T
A
-
K
L
A
E
V
L
C
R
L
A
P
G
N
M
G
R
V
F
F
S
N
S
G
T
E
A
V
E
A
A
M
K
I
A
K
A
S
T
------
G
K
P
G
I
A
Y
L
R
N
S
Y
H
G
K
T
L
G
A
L
S
I
T
G
R
D
K
H
R
R
Y
F
T
--
P
L
L
D
A
M
V
E
V
P
F
-------------------
G
D
L
A
A
L
R
E
A
L
N
R
---
E
D
V
G
A
L
M
I
E
P
I
Q
G
E
-
G
G
V
H
I
P
P
A
G
Y
L
Q
A
V
Q
Q
L
C
R
E
T
G
V
L
L
M
V
D
E
V
Q
T
G
L
G
R
T
G
K
L
F
A
C
E
-
W
-
D
G
I
E
P
D
V
L
M
L
S
K
S
L
S
G
G
-
L
I
P
I
G
A
T
L
C
R
A
D
L
W
Q
K
A
Y
----
G
T
A--
D
R
---
F
L
V
H
S
S
T
Y
G
G
G
N
L
A
S
V
V
A
L
S
A
L
R
E
I
L
A
Q
D
L
V
G
H
-
A
E
-
R
M
G
A
Y
F
K
Q
A
L
S
E
I
A
A
R
Y
P
F
V
S
E
V
R
G
R
G
L
M
L
G
I
Q
F
D
Q
A
------H
T
T
W
K
F
L
P
D
P
V
Q
A
H
L
R
A
A
M
D
R
M
E
Q
A
L
G
E
M
F
C
M
K
F
V
T
K
L
C
Q
D
H
K
I
L
T
F
--
I
T
A
N
---
S
S
T
V
I
R
I
Q
P
P
L
I
I
S
K
A
E
I
D
R
F
V
G
A
F
A
T
V
C
E
E
L
S
T
F
L
---
60
PsiBlast_CBE
43.34
33%
-47
- C1 -
1MGV
7
BIOA_ECOLI
B:
[27-314]
-------------
Y
P
V
V
S
-
A
E
G
C
E
L
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
M
S
H
V
M
-
F
G
-
G
I
-
T
H
A
P
A
I
-
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
R
Q
R
-
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
S
M
H
S
L
W
KG
Y
L
P
E
N
L
F
A
-
P
A
P
Q
-
S
R
M
-
D
G
E
-
W
D
E
R
D
M
V
G
F
A
R
------
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
-
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
-
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
----
N
G
E--
A
G
---
C
F
M
H
G
P
T
F
M
G
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
43.09
33%
-65
- C1 -
1QJ3
5
BIOA_ECOLI
B:
[27-314]
-------------
Y
P
V
V
S
-
A
E
G
C
E
L
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
M
S
H
V
M
-
F
G
-
G
I
-
T
H
A
P
A
I
-
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
R
Q
R
-
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
---------
L
P
E
N
L
F
A
-
P
A
P
Q
-
S
R
M
---
E
-
W
D
E
R
D
M
V
G
F
A
R
------
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
-
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
-
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
----
N
G
----
G
---
C
F
M
H
G
P
T
F
M
G
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
42.15
32%
-49
- C1 -
1S07
4
BIOA_ECOLI
B:
[27-314]
-------------
Y
P
V
V
S
-
A
E
G
C
E
L
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
M
S
H
V
M
-
F
G
-
G
I
-
T
H
A
P
A
I
-
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
R
Q
R
-
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
S
M
H
S
L
W
KG
Y
L
P
E
N
L
F
A
-
P
A
P
Q
-
S
R
M
-
D
G
E
-
W
D
E
R
D
M
V
G
F
A
R
------
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
A
T
G
K
L
F
A
C
E
-
H
-
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
-
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
----
N
G
E--
A
G
---
C
F
M
H
G
P
T
F
M
G
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
42.12
33%
-46
- C1 -
1MLZ
4
BIOA_ECOLI
B:
[27-314]
-------------
Y
P
V
V
S
-
A
E
G
C
E
L
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
M
S
H
V
M
-
F
G
-
G
I
-
T
H
A
P
A
I
-
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
R
Q
R
-
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
S
M
H
S
L
W
KG
Y
L
P
E
N
L
F
A
-
P
A
P
Q
-
S
R
M
-
D
G
E
-
W
D
E
R
D
M
V
G
F
A
R
------
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
-
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
-
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
----
N
G
E--
A
G
---
C
F
M
H
G
P
T
F
M
G
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
42.03
32%
-49
- C1 -
1S07
3
BIOA_ECOLI
A:
[27-314]
-------------
Y
P
V
V
S
-
A
E
G
C
E
L
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
M
S
H
V
M
-
F
G
-
G
I
-
T
H
A
P
A
I
-
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
R
Q
R
-
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
S
M
H
S
L
W
KG
Y
L
P
E
N
L
F
A
-
P
A
P
Q
-
S
R
M
-
D
G
E
-
W
D
E
R
D
M
V
G
F
A
R
------
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
A
T
G
K
L
F
A
C
E
-
H
-
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
-
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
----
N
G
E--
A
G
---
C
F
M
H
G
P
T
F
M
G
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
41.68
33%
-49
- C1 -
1QJ5
3
BIOA_ECOLI
B:
[27-314]
-------------
Y
P
V
V
S
-
A
E
G
C
E
L
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
M
S
H
V
M
-
F
G
-
G
I
-
T
H
A
P
A
I
-
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
R
Q
R
-
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
S
M
H
S
L
W
KG
Y
L
P
E
N
L
F
A
-
P
A
P
Q
-
S
R
M
-
D
G
E
-
W
D
E
R
D
M
V
G
F
A
R
------
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
-
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
-
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
----
N
G
E--
A
G
---
C
F
M
H
G
P
T
F
M
G
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
41.14
33%
-47
- C1 -
1MGV
5
BIOA_ECOLI
A:
[27-314]
-------------
Y
P
V
V
S
-
A
E
G
C
E
L
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
M
S
H
V
M
-
F
G
-
G
I
-
T
H
A
P
A
I
-
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
R
Q
R
-
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
S
M
H
S
L
W
KG
Y
L
P
E
N
L
F
A
-
P
A
P
Q
-
S
R
M
-
D
G
E
-
W
D
E
R
D
M
V
G
F
A
R
------
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
-
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
-
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
----
N
G
E--
A
G
---
C
F
M
H
G
P
T
F
M
G
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
40.39
33%
-44
- C1 -
1MLY
4
BIOA_ECOLI
B:
[27-314]
-------------
Y
P
V
V
S
-
A
E
G
C
E
L
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
M
S
H
V
M
-
F
G
-
G
I
-
T
H
A
P
A
I
-
E
L
C
R
K
L
V
A
M
T
P
Q
P
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
R
Q
R
-
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
S
M
H
S
L
W
KG
Y
L
P
E
N
L
F
A
-
P
A
P
Q
-
S
R
M
-
D
G
E
-
W
D
E
R
D
M
V
G
F
A
R
------
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
-
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
-
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
----
N
G
E--
A
G
---
C
F
M
H
G
P
T
F
M
G
N
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------