@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu20960: (2016-07-02 )
MENIALESSFLEYDINEPIKIYTGHFTIEVADDFFEILGEVKIAFLPKARLIFEGAISGNLSKLFEFEKAMKSNNMMINVPGFMKSEVLISGITDGSKGNKVSGILKRSILTSAETKVNRMEFTVVNFVNDLGRRIVHGRFKFSGRTKLKYKDWEIILDKRYDYSNKKIFDRLKNSGGYLITHVGYLKRVDDKLFDTKEVEPLISGLYWLLSFSAGRHVAIPTLEGYHNEEVIWSKYQVPLIDGWTNNITWFPKQKSPSLEHLFPKVIEKQEDPFWNKVLWEVLSWYSQAHSSSIVENKVVSVQVALETLAWVYLIVDRKSNISKSKYKYMNAAEKFREILSRFSIDLSIPKLFIDIKDNYDDGPHLFTVFRNKIVHPTRELDFDNPIDKLHVLYLGVWYLELLTLGILGYEGSYVNRLKVPIIEGVYEFVPWKTRDN
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10....-....-20--.........30.......---.---40.-....----...50.-.......-60-........70........80........90.......-..100.......--------------110.......120-------.......-130...--...-----.140-....----...150.-----..-------------..--..160.......170.......180..-.------....190..--.------------------...---.200.......210.......220...-......----230....-...-..240.-----------......250...--.....-260......-------.270.--......--------280-----.........------------------290------...-.....-300.......-----310----....-.....320...----------------...--.330.......340.......350.......360.......370.......380.......390...--...---------------.400..-....--.410.-.......420.-------.-.--...-----.430......--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MENIALES
S
F
L
E
YDI-NE
P
I
-
K
---
I
Y
T
G
H
F
T
I
E
V
A
D
D
F
F
E
I
L
---G---E
V
K
-
I
A
F
L----PK
A
R
L
I
-
F
EGAISG-
N
L
-
S
K
L
F
E
F
E
K
A
MKSN
N
M
M
I
NVPGFMKS
E
V
L
I
-
S
GITDGS-KG
N
K
V
S
G
I
L
K
R
S
--------------
I
LTSAETKV
N
R
M
E
-------
F
T
V
V
N
F
V
-
N
D
L
G
R
R
--
I
VH-----
G
R
F
K
-FSGR----
T
K
L
K
YK
D
-----
W
E
-------------
I
I
--
L
D
KRYDYS
N
K
K
I
F
D
R
L
KNSG
G
Y
L
I
T
H
V
-
G
------
Y
L
K
R
V
D
D
KL--F------------------
D
T
K
---
E
V
E
P
L
I
S
G
L
Y
W
L
L
SFSAG
R
H
V
A
--IPT-LEGYHN----E--
E
V
I
W-SKY-Q
V
P
L
ID-----------GWTNN
I
T
-WFPK--QKSP
S
-
L
E
H
L
F
P
K
V
I
-------
E
KQED--P
F
W
N
K
V
--------
L
-------
W
E
V
L
S
W
Y
S
Q
------------------AH-------S
S
S
-IVEN
K
-
V
V
S
V
Q
V
A
L
E
T
-----
L
------
A
W
V
Y
-
L
I
V
DRKSNIS
K
----------------
S
K
Y
--
K
Y
M
N
A
A
E
K
F
R
E
I
L
S
RFSIDLSI
P
K
L
F
I
D
I
KDNYDDG
P
H
L
F
T
V
F
R
N
KIVHPTRELDFDNP
I
D
K
L
H
V
L
Y
--
L
G
V
---------------
W
Y
L
E
L
L
-
T
L
G
I--LG-YE-GSY
V
N
R
LK
V
P
I
-------
I
-
E
--
G
V
Y
-----
E
FVPWKTRDN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
67.48
21%
9
- C3 -
4F92
1
U520_HUMAN
B:
[2-1724]
LAPRQVLDLEDLVFTQGSHFMANKRCQLPDGSFRRQRKGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIILDEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVREEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQLAGRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSMCPLRQFRKLPEEVVKKIEKKNFPFERLYDLNHNEIGELIRMPKMGKTIHKYVHLFPKLELSVHLQPITRSTLKVELTITPDFQWDEKVHGSSEAFWILVEDVDSEVILHHEYFLLKAKYAQDEHLITFFVPVFEPLPPQYFIRVVSDRWLSCETQLPVSFRHLILPEKYPPPTELLDLQPLPVSALRNSAFESLYQDKFPFFNPIQTQVFNTVYNSDDNVFVGAPTGSGKTICAEFAILRMLLQSSEGRCVYITPMEALAEQVYMDWYEKFQDRLNKKVVLLTGETSTDLKLLGKGNIIISTPEKWDILSRRWKQRKNVQNINLFVVDEVHLIGGENGPV
L
E
V
I
C
S
R
M
R
Y
I
S
S
Q
I
-
E
R
P
I
-
R
---
I
V
A
L
S
S
S
L
S
N
A
K
D
V
A
H
W
L
---
G
CSA
T
S
T
-
F
N
F
H
----
P
N
V
R
P
V
P
L
E
L
H
I
Q
G
F
N
I
-
S
H
T
Q
T
R
L
L
S
M
--------------
A
K
P
V
Y
-
H
A
I
T
K
H
S
-
P
K
K
P
V
I
V
F
V
P
S
-----------------------
R
K
Q
T
R
-------
L
T
A
I
D
I
L
-
T
T
C
A
A
D
--
I
Q
R
-----
Q
R
F
----------
L
H
C
T
E
K
D
-----
L
I
-------------
P
Y
--
L
E
K
---
L
S
D
S
T
L
K
E
T
L
L
N
G
V
G
Y
L
H
E
G
L
S
P
------
M
E
R
R
L
V
E
Q
L
--
F
------------------
S
S
G
---
A
I
Q
V
V
V
A
S
R
S
L
C
W
G
M
N
V
A
A
H
L
V
--
I
I
M
-
D
T
Q
Y
Y
N
GKIH
A
--
Y
V
D
Y
-
P
I
Y
-
D
V
L
Q
M
V
-----------
G
H
A
N
R
-----
P
L
--
Q
D
D
----
E
G
R
C
V
I
M
C
-------
Q
G
S
K
K
--
D
F
F
K
K
F
--------
L
-------
Y
E
P
L
P
V
E
S
H
------------------
L
D
HCMHDHF
N
A
E
-
I
V
T
K
T
-
I
E
N
K
Q
D
A
V
D
Y
-----
L
------
T
W
T
F
-
L
Y
R
R
M
T
Q
N
P
N
Y
YNL-------------
Q
G
I
--
S
H
R
H
L
S
D
H
L
S
E
L
V
E
Q
T
L
S
D
L
E
Q
S
K
C
-
I
S
I
E
D
E
M
D
V
A
P
L
-------------------
N
L
G
M
I
A
A
Y
Y
Y
--
I
N
Y
---------------
T
T
I
E
L
F
-
S
M
S
---
L
N
-
A
K
-
T
K
V
R
G
L
I
E
I
I
S
-------
N
-
A
--
A
E
Y
-----
E
N
I
P
I
R
H
H
E
D
NLLRQLAQKVPHKLNNPKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWSKDSYLKQLPHFTSEHIKRCTDKGVESVFDIMEMEDEERNALLQLTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLFPQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATGAHNYTLYFMSDAYMGCDQEYKFSVD
24
Fugue
58.10
18%
25
- C6 -
4X4W
12
TRNT1_HUMAN
A:
[1-409]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
F
T
M
K
L
Q
S
P
E
F
Q
S
L
F
-
T
E
G
L
-
K
---
S
L
T
E
L
F
V
K
E
--
N
H
E
L
R
I
A
---
G
---
G
A
V
-
R
D
L
L
N
G
V
K
P
Q
D
I
D
F
-
A
T
T
A
T
P
T
-
Q
M
-
K
E
M
F
Q
S
A
-----------------
G
I
R
M
I
-
N
G
T
I
T
A
R
-
L
H
E
E
N
F
E
I
T
T
L
R
--------------
I
D
V
T
--
T
D
G
A
E
V
E
-------
F
T
T
-
D
W
Q
-
K
D
A
E
R
R
DL
T
I
N
-----
S
M
F
L
G
F
D
G
T
----
L
F
D
Y
F
N
G
-----
Y
E
-------------
D
L
--
K
N
K
K
V
R
F
V
G
H
-
A
K
Q
R
I
Q
E
D
Y
L
R
I
L
R
Y
F
-
R
------
F
Y
G
R
I
V
D
K
P
GD
H
------------------
D
P
E
---
T
L
E
A
I
A
E
N
A
K
G
L
A
G
I
S
G
E
R
I
W
V
E
L
K
K
I
-
L
V
G
N
H
V
----
N
--
H
L
I
H
-
L
I
Y
-
D
L
------------------
D
V
A
P
-
Y
I
G
L
--
P
A
N
A
S
-
L
E
E
-
F
D
K
V
S
-------
K
N
V
D
G
--
F
---------------------------------------------------------------
S
P
K
-
P
V
T
L
L
A
S
L
F
K
-----
V
------
Q
D
D
V
-
T
K
L
D
L
R
L
K
I
A
K
----------------
E
E
K
--
N
L
G
L
F
I
V
K
N
R
K
D
L
I
K
A
T
D
S
S
D
P
L
K
P
Y
Q
D
F
I
I
D
S
D
A
T
T
R
V
C
E
L
L
K
Y
Q
-----
G
E
H
C
L
L
K
E
M
Q
Q
W
S
I
P
P
--
F
P
V
---------------
S
G
H
D
I
R
-
K
V
G
I
SS
G
K
-
E
I
-
G
A
L
L
Q
Q
L
R
E
Q
W
-------
K
-
K
--
S
G
Y
QME
K
D
E
L
L
S
Y
I
K
K
T
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
57.42
15%
6
- C2 -
4J1Q
1
A:
[20-445]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H
M
E
R
L
M
L
E
P
V
W
E
K
Q
---
N
E
E
L
-
S
----
Y
T
E
H
I
I
V
L
F
E
T
E
--
R
S
V
---
T
---
D
S
I
-
A
S
H
M
----
K
D
A
R
V
I
-
T
L
N
E
A
V
G
-
H
I
-
A
E
R
Y
Q
C
Y
M
Q
N
I
F
E
L
L
Q
S
K
V
R
K
L
S
A
G
R
I
I
I
-
Q
A
I
V
P
L
E
-
K
E
K
Q
L
F
A
G
V
S
-
G
--------------
L
F
K
T
A
E
I
E
F
S
K
L
T
-------
A
Q
V
I
E
I
E
-
K
P
E
E
M
I
--
D
L
H
-----
L
K
L
K
-
D
D
S
R
R
PFD
K
Q
I
R
Y
E
A
G----
Y
R
-------------
F
V
--
K
G
W
R
E
M
V
D
T
L
H
M
--
P
W
R
D
E
G
V
Y
L
I
T
---
G
------
G
A
G
S
L
G
-
L
L
--
F
------------------
A
K
E
---
I
A
N
R
T
G
R
S
T
I
V
L
T
G
R
S
V
L
S
E
D
K
--
E
N
E
-
L
E
A
L
R
S
----
I
G
A
E
V
V
Y
-
R
E
A
-
D
V
S
-----------------------------
D
Q
H
A
-
V
R
H
L
L
E
E
I
K
-------
E
R
Y
G
T
----
L
N
G
I
--------
I
HG
A
G
S
S
K
D
R
F
I
I
H
K
T
N
------------------
E
E
-------
F
Q
E
-
V
L
Q
P
K
-
V
S
G
L
L
H
V
D
E
C
S
KDFP
L
------
D
F
F
I
-
F
F
S
S
V
S
G
C
L
G
N
----------------
A
G
Q
--
A
D
Y
A
A
A
N
S
F
M
D
A
F
A
E
Y
R
R
S
L
A
A
S
K
-----------
K
R
F
G
S
T
I
S
F
N
W
P
L
W
E
E
G
G
M
Q
V
G
A
E
D
E
K
R
M
L
K
T
--
T
G
M
---------------
V
P
M
P
T
D
-
S
G
L
K
--
A
F
-
Y
Q
-
G
I
V
S
D
K
P
Q
V
F
V
-------
M
-
E
--
G
-------
Q
L
Q
K
M
K
Q
K
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
54.32
11%
-31
* C6 *
1VD5
4
UGL_BACGL
A:
[1-377]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
W
Q
Q
A
-
I
G
D
A
-
L
---
G
I
T
A
R
N
L
K
K
F
G
D
R
F
P
H
V
S
---
D
---
G
S
N
-
K
Y
V
L
----
N
D
N
T
D
W
-
T
D
G
F
W
S
G
-
I
L
-
W
L
C
Y
E
Y
T
G
D
E
Q
Y
R
E
G
A
V
R
T
V
A
S
F
R
E
R
L
D
R
F
E
N
L
D
H
H
D
-
I
G
F
L
Y
S
L
S
A
K
A
Q
--------------
W
I
V
E
K
D
E
S
A
R
K
L
A
-------
L
D
A
A
D
V
L
-
M
R
R
W
R
A
--
D
A
------
G
I
I
Q
-
A
W
G
P
----
K
G
D
P
E
N
G
-----
G
R
-------------
I
I
--
I
D
C
L
L
N
L
P
L
L
L
W
A
G
E
Q
T
G
D
P
E
Y
R
R
V
A
E
-
A
------
H
A
L
K
S
R
R
F
L
--
V
------------------
R
G
D
---
D
S
----
S
Y
H
T
F
Y
F
D
P
E
N
G
N
A
I
R
--
G
G
T
-
H
Q
G
N
-
T
----
D
--
G
S
T
W
-
T
R
G
-
Q
A
W
G
I
Y
-----------
G
F
A
L
N
S
R
-
Y
L
G
N
--
A
D
L
L
E
-
T
A
K
R
M
A
R
H
F
-------
L
A
R
V
P
--
E
-----------------------
D
G
V
V
Y
W
D
------------------
F
E
-------
V
P
Q
-
E
P
S
S
Y
-
R
D
S
S
A
S
A
I
T
A
-----
C
------
G
L
L
E
-
I
A
S
Q
L
D
E
S
D
P
E
----------------
R
Q
R
--
F
I
D
A
A
K
T
T
V
T
A
L
R
D
G
Y
A
E
R
---------------
D
D
G
E
A
E
G
F
I
R
R
G
S
Y
H
V
R
G
G
I
S
P
D
D
Y
-----
T
I
W
--
G
D
Y
---------------
Y
Y
L
E
A
L
-
L
R
L
E
--
R
G
-
V
T
-
G
Y
W
Y
E
R
G
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
50.23
16%
1
* C4 *
4N9N
-
ENLYS_BPT4 (first)
A:
[604-878]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
-
N
L
I
D
M
K
---
L
F
H
-
H
Y
C
T
K
V
W
P
T
I
T
A
A
K
VSG
P
---
E
I
W
-
R
D
Y
I
----
P
E
L
A
F
D
-
Y
P
------
F
L
M
H
A
L
L
A
F
S
A
T
H
L
S
R
T
E
----
T
G
L
---------
E
Q
Y
V
S
S
-
H
R
L
D
A
L
R
L
L
R
E
A
--------------
V
L
E
I
S
E
N
N
T
D
A
L
V
-------
A
S
A
L
I
L
I
M
D
S
L
A
N
A
--
S
V
D
-----
N
I
F
E
M
L
R
I
D
----
E
G
L
R
L
K
I
-----
Y
K
D
TEGYYTIGIGHL
L
T
--
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
------------
K
D
E
A
E
K
L
--
F
------------------
N
Q
D
---
V
D
A
A
V
R
G
I
L
R
-----
N
A
K
L
K
P
V
--
Y
D
S
-
L
D
A
V
R
R
----
A
--
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
-----------
G
F
T
N
S
L
R
M
L
Q
Q
K
--
R
W
D
E
A
-
A
V
N
L
A
K
S
R
W
-------
Y
N
Q
T
P
--
N
R
A
K
R
V
--------
I
-------
T
T
F
R
T
G
T
W
D
------------------
A
Y
-------
V
D
S
M
S
P
S
A
W
-
I
F
H
V
K
G
A
A
T
I
-----
L
------
T
A
V
W
-
P
L
S
E
R
S
K
F
H
N
I
----------------
I
S
V
--
D
L
S
D
L
G
D
V
I
N
P
D
V
G
T
I
T
E
L
V
C
F
D
E
S
I
A
D
L
Y
P
V
G
L
D
S
P
Y
L
I
T
L
A
Y
L
D
K
L
H
--
R
E
K
N
Q
G
D
F
I
L
R
V
F
T
F
P
AL
L
D
K
---------------
T
F
L
A
L
L
M
T
G
D
L
--
G
A
M
R
I
M
R
S
Y
Y
K
L
L
R
G
F
A
-------
T
-
E
VK
D
K
V
-----
W
F
L
E
G
V
T
Q
V
L
PQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
45.02
18%
16
- C3 -
4YCZ
-
?
B:
[314-1176]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
R
Y
A
A
L
A
K
D
A
Y
Q
Q
M
G
T
A
--
P
---
V
T
E
P
P
Q
V
I
L
G
T
E
D
L
L
S
R
L
---
Y
---
D
E
K
M
D
D
T
L
----
A
T
A
A
A
Q
-
L
A
A
L
W
R
E
-
H
V
-
D
E
T
-
P
F
E
K
A
N
Y
L
A
N
L
A
L
Q
I
H
H
P
-
L
P
Q
T
L
F
-
R
W
L
N
E
Y
H
M
Y
G
S
Q
V
D
D
I
L
R
H
R
PSPACHSL
F
W
Q
A
V
F
I
A
L
K
V
G
D
A
A
R
L
L
D
Q
AGWGHV
Y
A
Y
V
N
V
Q
-
R
A
V
D
E
T
--
I
A
V
L
E
SCP
T
L
F
R
-
V
R
A
R
----
G
L
L
E
H
L
R
R
F
A
E
G
W
E
-------------
I
Y
E
N
L
N
I
V
F
D
I
V
L
G
Q
Q
G
A
I
L
E
A
A
Q
D
W
L
E
A
T
V
-
G
LAN
S
E
S
Y
L
D
R
L
A
R
A
F
--
H
T
AVESDFV
E
I
G
M
A
C
V
F
ED
N
I
K
---
G
V
I
G
L
L
R
G
W
S
L
P
I
A
A
A
V
A
E
I
A
S
--
L
G
K
W
L
E
V
D
G
I
----
K
--
D
S
T
L
-
V
Q
Y
-
A
Q
A
L
A
D
YEGLSSVQDRD
G
W
E
L
S
I
S
-
V
L
G
R
MP
E
R
S
E
E
M
V
R
D
L
V
E
H
L
V
Q
Q
LHVDS
N
A
T
V
D
--
R
L
W
F
L
L
N
ELGM
I
E
F
A
-------
E
D
T
T
E
T
Y
G
D
I
L
ARDSHR
Y
G
E
A
M
W
Y
Y
A
L
A
H
-------
R
P
N
-
K
V
R
E
V
M
N
L
L
T
S
Y
S
L
I
Q
-----
P
PAND
L
D
D
Y
L
Y
K
L
L
N
D
R
K
N
T
L
E
Q
C
A
S
QDMEA
A
E
L
L
G
K
M
L
S
G
Y
--
A
S
L
R
Q
F
Y
D
I
R
P
H
A
T
P
L
S
R
R
K
Q
A
A
T
A
L
I
S
V
I
A
S
S
D
D
E
D
F
L
L
A
L
L
G
E
A
L
V
F
V
S
-----
D
P
T
L
D
Q
I
D
V
L
L
--
K
A
I
E
D
L
Q
A
VGSR
V
Y
N
A
C
D
E
F
L
Q
L
V
-
L
A
S
A
--
P
G
-
G
S
-
S
L
V
A
S
Q
L
Q
R
S
L
SGTGG
E
D
I
M
R
--
R
L
R
-----
L
G
L
A
K
D
L
A
G
L
WLAEA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
42.42
15%
26
- C4 -
4PW8
1
T23O_HUMAN
A:
[26-367]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I
Y
G
N
Y
L
H
L
E
K
V
L
N
A
Q
E
L
-
Q
S
E
T
-
K
GNK
I
H
D
E
H
L
F
I
I
T
H
Q
A
Y
E
L
W
F
---
K
---
Q
I
--
L
W
E
L
----
D
S
V
R
E
I
-
F
Q
N
G
H
V
R
-
D
E
-
R
N
M
L
K
V
V
S
R
M
H
R
V
S
V
I
L
K
L
L
V
Q
-------------------------
Q
F
S
--------------
I
L
E
T
M
----------------------------------------------------
T
A
L
D
F
N
D
-----
F
R
-------------
E
Y
--
L
S
P
A
S
G
F
Q
S
--------
L
Q
F
R
L
L
E
N
K
I
-
G
------
V
L
Q
E
E
N
E
L
L
--
L
------------------
K
S
E
---
Q
E
K
T
L
L
E
L
V
E
A
W
L
E
R
T
P
G
----------
L
E
P
H
G
F
----
N
----
F
W
-
G
K
L
-
E
K
N
I
T
R
-----------
G
L
E
E
E
F
I
-
R
I
Q
A
--
K
E
E
S
E
-
E
K
E
E
Q
V
A
E
F
-------
Q
K
Q
K
E
--
V
L
L
S
----------
L
-------
F
D
-----
E
K
------------------
R
H
-------
E
H
L
-
L
S
K
G
E
-
R
R
L
S
Y
R
A
L
Q
G
-----
A
------
L
M
I
Y
-
F
Y
R
E
E
----------------------------------------
P
R
F
Q
V
P
F
Q
L
L
T
S
L
M
D
I
D
S
L
M
T
K
W
R
Y
N
H
V
C
M
V
H
R
M
L
G
S
R
Y
K
V
----------------------------------
F
V
D
L
F
-
N
L
S
T
--
Y
------------
L
I
P
-----------------------
R
H
W
I
P
K
M
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
39.76
9%
23
- C4 -
3E0S
3
?
A:
[9-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
D
A
H
-----------------------
A
S
I
H
E
N
V
R
R
L
L
---
Q
---
F
T
T
-
S
I
M
E
----
A
N
E
E
G
I
-
R
K
D
---
I
-
D
S
-
E
F
L
H
D
F
R
V
A
I
R
R
S
R
S
I
L
R
L
-----------------------
L
N
G
V
F
D
P
E
--------------
K
T
A
W
M
L
A
G
L
R
E
L
G
K
R
-----
T
N
D
L
R
D
S
-
D
V
Y
L
L
R
--
R
E
E
-----
Y
T
S
L
-
L
P
P
S
----
L
R
P
A
L
D
P
-----
F
F
-------------
S
D
--
L
E
A
D
K
R
L
H
H
R
Q
F
C
R
Y
L
T
G
-------------------------------------------------
R
---
E
Y
S
G
F
M
T
S
L
K
E
F
I
A
E
--------------------------------------------------------------
G
E
--
L
P
D
P
E
-
T
A
P
L
A
A
E
P
T
-------
G
D
V
A
A
--
K
T
I
R
K
A
--------
L
-------
K
K
V
L
V
H
G
R
S
------------------
D
A
-------
E
L
H
-
E
L
R
I
D
-
C
K
K
L
R
Y
L
L
E
F
-----
F
------
A
S
L
F
-
P
--------
P
K
----------------
A
T
A
--
Q
V
L
R
Q
M
K
T
L
Q
D
N
L
G
T
F
V
D
L
T
V
Q
M
E
F
L
Q
S
R
L
E
T
I
S
E
A
A
A
I
G
G
L
L
T
T
L
Y
R
K
R
E
K
V
R
E
H
F
H
E
I
F
S
G
F
D
S
N
--
E
T
G
---------------
E
L
F
D
E
L
-
L
T
G
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
27.56
25%
-
- C7 -
3GGZ
-
DID2_YEAST
E:
[16-27]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
D
K
L
A
Q
R
L
R
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
25.50
7%
13
- C3 -
1Z6T
1
APAF_HUMAN
A:
[1-586]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MD
A
K
A
R
N
C
L
L
Q
H
R
E
A
L
E
K
DIKT
S
Y
I
M
D
H
M
I
S
D
GFLT
I
S
E
E
E
K
V
R
N
EPT
Q
Q
Q
R
A
A
M
L
I
K
M
I
L
K
KD
N
D
S
Y
V
S
F
Y
N
A
L
L
H
E
GY
K
D
L
A
A
L
L
H
D
G
I
P
V
V
G
I
T
S
Y
V
R
T
V
L
-
C
E
G
G
-
V
---
P
Q
R
P
V
V
F
V
T
R
K
K
L
V
N
A
I
Q
---
Q
---
K
L
S
-
K
L
K
G
----
E
P
G
W
V
T
-
I
H
G
--
M
A
-
G
C
-
G
K
S
V
L
A
A
E
A
V
R
D
H
S
L
L
E
G
C
F
P
G
G
V
H
W
V
S
V
-
G
K
Q
D
K
S
G
-
L
L
M
K
L
Q
N
L
C
T
R
L
--------------
D
Q
D
E
S
F
S
Q
R
L
P
L
N
-------
I
E
E
A
K
D
R
-
L
R
I
L
M
L
--
R
K
H
-----
P
R
S
L
-
L
I
L
D
----
D
V
W
D
S
W
V
-----
L
K
A
F
DSQ
C
Q
------
I
L
--
L
T
T
R
----
D
K
S
V
T
D
S
V
M
G
P
K
Y
V
V
P
V
E
S
-
S
------
L
G
K
E
K
G
L
E
I
--
L
------------------
S
L
F
V
NM
K
K
A
D
L
P
E
Q
A
H
S
I
I
K
E
C
K
G
S
P
L
V
--
V
S
L
-
I
G
A
L
L
R
----
D
--
F
----
P
N
R
-
W
E
Y
Y
L
K
-----------
Q
L
Q
N
K
Q
F
-
K
R
I
R
--
K
S
S
S
Y
-
D
Y
E
A
L
D
E
A
M
-------
S
I
S
V
E
M
L
R
E
D
I
K
D
--------
Y
-------
Y
T
D
L
S
I
L
Q
K
------------------
D
V
-------
K
---
V
P
T
K
V
-
L
C
I
L
W
D
M
E
T
E
-----
E
------
V
E
D
I
-
L
Q
E
F
V
N
K
S
L
L
F
----------------
C
D
R
--
N
G
K
S
F
R
Y
Y
L
H
D
L
Q
V
D
F
L
T
E
K
N
C
S
Q
L
Q
D
L
H
K
K
I
I
T
Q
F
Q
R
Y
H
Q
P
H
T
L
S
P
D
Q
E
D
C
M
Y
W
Y
N
F
L
A
Y
H
M
A
S
A
---
K
M
H
---------------
K
E
L
C
A
L
-
M
F
S
L
--
D
W
-
I
K
-
A
K
T
E
L
V
G
P
A
H
L
-------
I
-
H
--
E
F
V
-----
E
Y
R
H
I
L
D
E
K
D
C
A
V
S
E
N
F
Q
E
F
L
S
L
N
GHLLGRQPFPN
I
V
Q
L
G
L
C
EPETS
E
V
Y
Q
Q
A
K
L
Q
A
K
Q-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
24.38
27%
-570
- C5 -
2JN9
-
YKVR_BACSU
A:
[54-68]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
----
P
E
R
D
L
A
-
F
R
G
E
M
T
N
-
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
21.17
25%
-73
* C8 *
3ZO0
-
GCAA_MOUSE (first)
A:
[114-168]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
P
P
P
E
E
E
M
T
K
K
Q
-------
V
T
L
T
C
M
V
-
T
D
F
M
P
E
--
D
I
Y
-----
V
E
W
T
-
N
N
G
K
----
T
E
L
N
Y
K
N
-----
T
E
-------------
P
V
--
L
D
S
D
G
S
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
20.37
25%
-65
- C8 -
1IGT
-
GCAA_MOUSE
B:
[351-405]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
P
P
P
E
E
E
M
T
K
K
Q
-------
V
T
L
T
C
M
V
-
T
D
F
M
P
E
--
D
I
Y
-----
V
E
W
T
-
N
N
G
K
----
T
E
L
N
Y
K
N
-----
T
E
-------------
P
V
--
L
D
S
D
G
S
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
20.23
23%
25
- C7 -
2QIZ
-
UFD2_YEAST
A:
[862-938]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
G
R
K
T
G
L
A
S
----------------
P
E
F
I
E
K
L
L
N
F
A
N
K
A
E
E
---
Q
R
K
A
D
E
E
E
D
L
E
Y
G
D
V
P
D
E
F
L
D
-
P
L
M
Y
T
I
M
K
D
P
V
I
L
P
A
S
K
M
N
I
D
R
S
T
I
K
A
H
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
19.58
23%
34
- C7 -
3M63
-
DSK2_YEAST (first)
A:
[848-924]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
G
R
K
T
G
L
A
S
----------------
P
E
F
I
E
K
L
L
N
F
A
N
K
A
E
E
---
Q
R
K
A
D
E
E
E
D
L
E
Y
G
D
V
P
D
E
F
L
D
-
P
L
M
Y
T
I
M
K
D
P
V
I
L
P
A
S
K
M
N
I
D
R
S
T
I
K
A
H
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
19.38
23%
15
- C7 -
3M62
-
UFD2_YEAST
A:
[848-924]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
G
R
K
T
G
L
A
S
----------------
P
E
F
I
E
K
L
L
N
F
A
N
K
A
E
E
---
Q
R
K
A
D
E
E
E
D
L
E
Y
G
D
V
P
D
E
F
L
D
-
P
L
M
Y
T
I
M
K
D
P
V
I
L
P
A
S
K
M
N
I
D
R
S
T
I
K
A
H
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
17.51
36%
154
* C3 *
1P5L
1
RL1_HELPY
A:
[1-19]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
--
K
V
S
K
R
-
L
E
K
L
F
S
K
I
Q
-------
N
D
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
16.56
23%
8
* C5 *
3LLT
1
?
A:
[163-240]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
P
E
N
I
L
L
D
D
P
Y
F
E
K
S
L
I
T
V
-
R
R
V
T
D
G
K
----------
K
I
Q
--------------
I
Y
R
T
K
S
T
G
I
K
L
I
D
-------
F
G
C
A
T
F
K
-
S
D
Y
H
G
S
--
I
I
N
-----
T
R
--------------
Q
Y
R
A
-----
P
E
-------------
V
I
--
L
N
L
G
W
D
V
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
15.09
19%
-120
- C7 -
3KP1
-
OAMS_CLOSD
E:
[49-64]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
R
S
-
V
L
L
R
--
M
G
-
F
S
-
S
L
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
13.98
21%
7
* C7 *
1WTY
-
?
A:
[73-91]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
W
L
E
M
L
E
L
R
N
L
T
N
H
T
Y
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------