@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu21500: (2016-07-03 )
MIDYSQFPRKNILCVDMKSFYASVSAVTMGLNPLTCYLAVVGNTDRQGSVVLAASPALKKDFGIKTGSRLFEIPEDPRIHIVNPQMKLFIRVSTEITKLFYRFVPEKCVHTYSIDESFLDAGKEDPEEMAKAIQSSMWREFGLMCTVGIGDNMLLSKLALDLESKKTKSGIARWRYEDVPNKLWKVRPLSKMWGIGGRMERNLNRMGISTIGQLAKFPLELLEKKFGIMGNQLYYHAHGIDLSEIGAPLMQGQISFGKSQILLRDYTRSEEIKAVLLEICEEVARRARTHNKVGRTISLGIGYSKDELGGGFHRSKTIDLPTSITMDIYRCCLMLFNKFYSGKTVRSVSVTLSNIEDDVNQQLSLFEVDNEKRRKLGFVMDGIRSKYGSKAILRAVSYTPAGTALQRAGLTGGHKS
Atome Classification :
(20 SA)
-----------------------------------------------------------.........10........20........30..-------.--.....40....--....50........60........70.....-..-..80..-------.-...-..90........100.......110.......120.------.---------------------------------------.----------------------------------------------------..-------------------------..130.......140.......150.......160.......170.-......180.....-..190.......200........210.......220......-.230.......240.......-250.......260...--....270.......280.......290--.--...----.....300......-.310-........--320---....---....330.....---..340.-----........350.......360.......370.......380.......390.......400.......410....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------MI
D
Y
SQFPRK
N
I
L
C
V
D
M
K
S
F
Y
A
S
V
S
A
V
T
MGL
N
P
-------
L
--
T
C
Y
L
A
VVGNTD--RQG
S
V
V
L
AASPA
L
K
K
DFGIKTG
S
R
L-FEIPE-D
P
-
R
I
H
I
VN-------P-
Q
M
K
-
L
F
I
R
V
S
T
E
I
T
K
L
F
Y
R
FV
P
E
K
C
V
H
T
YSI
D
E
S
F
L
DAGK------E---------------------------------------
D
----------------------------------------------------
P
E
-------------------------
E
M
A
K
A
I
Q
S
S
M
W
R
EFG
L
M
C
T
VGIGD
N
M
L
L
S
K
L
A
L
D
L
ESKKTKSG
I
A
R-WRYEDVPNK
L
W
KVR-
P
L
S
K
M
WGIG
G
R
M
E
R
-
N
L
N
RM
G
I
S
T
I
G
Q
L
A
K
F
P
L
E
L
L
E
K
K
F
GI-MGN
Q
L
Y
Y
H
AHGI
D
L
S
E
IGA
P
L
-
M
QGQISFGK
S
Q
I
L
L
RD--YT
R
S
E
E
I
K
A
V
L
L
E
I
C
E
E
V
A
R
R
A
R
T
H----N--KVG----
R
T
I
S
LGIGY
S
K
D
EL-GGG--FHRSKTID--LP----T
S
I
T
---
M
D
I
Y
R
C
C
L
M
L
F
N
---
K
FY--S-----G
K
T
V
R
S
V
S
V
T
L
S
N
I
E
D
D
V
N
QQ
L
S
L
F
EVD
N
E
K
R
R
K
L
G
F
V
M
D
G
I
R
S
KYG
S
K
A
I
L
R
A
VSYTPA
G
T
A
L
Q
RAGLTGGHKS
12
PsiBlast_PDB
78.97
26%
0
- C- -
4F4W
-
DPO4_SULAC (first)
A:
[3--164]
----------------------------------------------------------------------
V
I
F
V
D
F
D
Y
F
F
A
Q
V
E
E
V
---
L
N
P
QYKG
K
P
L
V
--
V
C
V
Y
S
--
G
R
T
K
--
T
S
G
A
V
A
T
A
N
Y
E
A
R
K
--
L
G
V
K
A
G
M
P
I
-
I
K
A
M
Q
-
I
A
-
P
S
A
I
Y
V
-------
P
-
M
R
K
P
I
Y
E
A
F
S
N
R
I
M
N
L
L
N
K
H
A
D
K
--
I
E
V
A
S
I
D
E
A
Y
L
D
V
T
N
KVEGN
F
E
---------------------------------------
N
----------------------------------------------------
G
I
-------------------------
E
L
A
R
K
I
K
Q
E
I
L
E
K
E
K
I
T
V
T
V
G
V
A
P
N
K
I
L
A
K
I
I
A
D
-
K
S
K
P
N
G
L
G
V
I
R
P
T
E
V
Q
D
F
L
N
E
L
-----
D
I
D
E
I
P
G
I
G
S
V
L
A
R
-
R
L
N
E
L
G
I
Q
K
L
R
D
I
L
S
K
N
Y
N
E
L
E
K
---
I
-
T
G
K
A
K
A
L
Y
L
L
K
L
A
Q
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
76.27
19%
-15
- C1 -
4ECQ
7
POLH_HUMAN
A:
[6-434]
----------------------------------------------------------------
T
G
Q
D
R
V
V
A
L
V
D
M
D
C
F
F
V
Q
V
E
Q
R
Q
N
-
P
H
L
-------
R
--
N
K
P
C
A
V
V
Q
Y
K
S
--
W
K
G
G
G
I
I
A
V
S
Y
E
A
R
A
-
F
G
V
T
R
S
M
W
A
-
D
D
A
K
K
-
L
C
P
D
L
L
L
A
Q
V
R
ESRGK
A
-
N
L
T
-
K
Y
R
E
A
S
V
E
V
M
E
I
M
S
R
F
A
---
V
I
E
R
A
S
I
D
E
A
Y
V
D
L
T
S
A
V
----
Q
E
R
L
Q
K
L
QG-------------------------------
Q
P
I
S
ADLLPSTYIEGLPQGPTVQ
K
E
G
M
R
K
Q
G
L
F
Q
W
L
D
S
LQIDNLTS
P
D
L
Q
L
T
V
G
A
-------------------------
V
I
V
E
E
M
R
A
A
I
E
R
E
T
G
F
Q
C
S
A
G
I
S
H
N
K
V
L
A
K
L
A
C
G
L
N
K
P
---
N
R
Q
T
L
-
V
S
H
G
S
V
P
Q
L
F
S
Q
-
M
-
P
I
R
K
I
R
S
L
G
G
K
L
G
A
S
V
I
E
I
L
G
I
E
Y
M
G
E
L
T
Q
F
T
E
S
Q
L
Q
S
H
F
G
E
K
N
G
S
W
L
Y
A
M
C
R
G
I
E
H
D
P
V
K
P
R
---
Q
L
P
K
T
I
G
C
S
K
N
F
P
G
K
TA
L
A
T
R
E
Q
V
Q
W
W
L
L
Q
L
A
Q
E
L
E
E
R
L
T
K
D
R
N
D
N
D
--
R
V
A
----
T
Q
L
V
V
S
I
R
V
Q
G
D
K
R
-
L
S
S
--
L
R
R
C
C
A
L
T
RY
D
A
----
H
K
M
S
---
H
D
A
F
T
V
I
K
N
C
N
T
SGI
Q
T
E
--
W
-----
S
P
P
L
T
M
L
F
L
C
A
T
K
F
S
A
-----------------------------------------------------------
52
Fugue
70.28
21%
15
- C1 -
2W7O
5
POLK_HUMAN
A:
[15-501]
KEK
I
N
K
I
I
M
E
A
T
KGS
R
F
Y
G
N
E
L
K
K
E
K
Q
V
N
Q
R
I
E
N
M
M
Q
Q
K
A
Q
IT
S
Q
Q
L
R
K
A
Q
L
Q
V
D
R
F
A
M
E
L
E
Q
S
R
N
L
S
N
T
I
V
H
I
D
M
D
A
F
Y
A
A
V
E
M
R
D
N
--
P
E
-------
L
--
K
D
K
P
I
A
V
G
S
M
------
S
M
L
S
T
S
N
Y
H
A
R
R
-
F
G
V
R
A
A
M
P
G
-
F
I
A
K
R
L
C
P
-
Q
L
I
I
V
P
-------
P
-
N
F
D
-
K
Y
R
A
V
S
K
E
V
K
E
I
L
A
D
Y
D
P
N
--
F
M
A
M
S
L
D
E
A
Y
L
N
I
T
K
------
H
---------------------------------------
L
----------------------------------------------------
E
E
R
Q
NWPEDKRRYFIKQN
S
V
V
F
G
TS
A
Q
E
V
V
K
E
I
R
F
R
I
E
Q
K
T
T
L
T
A
S
A
G
I
A
P
N
T
M
L
A
K
V
C
S
D
K
N
K
P
N
G
Q
Y
Q
I
L
P
---
N
R
Q
A
V
M
D
F
I
K
D
L
-
P
I
R
K
V
S
G
I
G
K
V
T
E
K
-
M
L
K
A
L
G
I
I
T
C
T
E
L
Y
Q
Q
R
A
L
L
S
L
L
F
S
E
T
-
S
W
H
Y
F
L
H
I
S
L
G
L
G
S
T
H
L
T
R
D
G
-
E
R
K
S
M
S
V
E
R
T
F
S
E
I
N
K
-----
A
E
E
Q
Y
S
L
C
Q
E
L
C
S
E
L
A
Q
D
L
Q
K
E
----
R
--
L
K
G
----
R
T
V
T
I
K
L
K
N
V
N
----
F
E
V
--
K
T
R
A
S
T
V
S
--
S
V
----
V
S
T
A
---
E
E
I
F
A
I
A
K
E
L
L
K
---
T
E
I
--
D
ADFPH
P
L
R
L
R
L
M
G
V
R
I
S
S
F
P
N
E
----------------------------------------------------------
51
Fugue
70.23
21%
23
- C1 -
2OH2
4
POLK_HUMAN
A:
[15-499]
KE
K
I
N
K
I
I
M
E
A
T
KGS
R
F
Y
G
N
E
L
K
K
E
K
Q
V
N
Q
R
I
E
N
M
M
Q
Q
K
A
Q
IT
S
Q
Q
L
R
K
A
Q
L
Q
V
D
R
F
A
M
E
L
E
Q
S
R
N
L
S
N
T
I
V
H
I
D
M
D
A
F
Y
A
A
V
E
M
R
D
N
--
P
E
-------
L
--
K
D
K
P
I
A
V
G
S
M
------
S
M
L
S
T
S
N
Y
H
A
R
R
-
F
G
V
R
A
A
M
P
G
-
F
I
A
K
R
L
C
P
-
Q
L
I
I
V
P
-------
P
-
N
F
D
-
K
Y
R
A
V
S
K
E
V
K
E
I
L
A
D
Y
D
P
N
--
F
M
A
M
S
L
D
E
A
Y
L
N
I
T
K
------
H
---------------------------------------
L
----------------------------------------------------
E
E
R
Q
N
WPEDKR
R
Y
F
I
KN
S
V
V
F
G
TS
A
Q
-
E
V
V
K
E
I
R
F
R
I
E
Q
K
T
T
L
T
A
S
A
G
I
A
P
N
T
M
L
A
K
V
C
S
D
K
N
-
K
P
N
G
Q
Y
Q
I
L
-
P
N
R
Q
A
V
M
D
F
I
-
K
D
L
-
P
I
R
K
V
S
G
I
G
K
V
T
E
K
-
M
L
K
A
L
G
I
I
T
C
T
E
L
Y
Q
Q
R
A
L
L
S
L
L
F
S
E
T
-
S
W
H
Y
F
L
H
I
S
L
G
L
G
S
T
H
L
T
R
D
G
-
E
R
K
S
M
S
V
E
R
T
F
S
E
I
N
K
-----
A
E
E
Q
Y
S
L
C
Q
E
L
C
S
E
L
A
Q
D
L
Q
K
E
----
R
--
L
K
G
----
R
T
V
T
I
K
L
K
N
V
N
----
F
E
V
--
K
T
R
A
S
T
V
S
--
S
V
----
V
S
T
A
---
E
E
I
F
A
I
A
K
E
L
L
K
---
T
E
I
--
D
-----
A
D
F
-------------------------------------------------------
P
H
P
L
R
L
R
L
M
G
V
R
I
S
S
F
P
24
HHSearch
69.76
21%
-0
- C1 -
4Q45
5
DPO4_ECOLI
F:
[2-342]
-------------------------------------------------------------------
S
R
K
I
I
H
V
D
M
D
C
F
F
A
A
V
E
M
R
D
N
-
P
A
L
-------
R
--
D
I
P
I
A
I
G
G
S
R
---
E
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
-
F
G
V
R
S
A
M
P
T
-
G
M
A
L
A
-
L
C
P
H
L
T
L
L
P
-------
G
-
R
F
D
-
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
--
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
SVHCH-
G
---------------------------------------
S
----------------------------------------------------
A
T
-------------------------
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
---
N
G
Q
F
V
-
I
T
P
A
E
V
P
A
F
L
Q
T
-
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
---
R
L
R
K
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
L
A
K
V
----
K
PD
L
L
I
----
A
R
Q
G
V
K
L
K
F
D
D
F
----
Q
Q
--
T
--
T
Q
E
H
V
--
W
P
----
R
L
N
K
---
A
D
L
I
A
T
A
R
K
T
W
D
---
E
R
R
--
G
-----
G
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-----------------------------------------------------------
17
PsiBlast_PDB
67.23
24%
0
- C- -
3QZ8
-
A:
[3--107]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
SLKG
K
P
V
V
--
V
C
V
F
S
--
G
R
F
E
--
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
--
F
G
V
K
A
G
I
P
I
-
V
E
A
K
K
-
I
L
-
P
N
A
V
Y
L
-------
P
-
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
--
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
------
K
VRD
Y
R
----------------------------------
E
----------------------------------------------------
A
Y
-------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
---
P
N
G
I
K
V
-
I
D
D
E
E
V
-
K
R
L
I
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
---
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
67.23
24%
0
- C- -
3QZ7
-
A:
[3--107]
----------------------------------------------------------------------
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
---
L
N
P
SLKG
K
P
V
V
--
V
C
V
F
S
--
G
R
F
E
--
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
--
F
G
V
K
A
G
I
P
I
-
V
E
A
K
K
-
I
L
-
P
N
A
V
Y
L
-------
P
-
M
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
--
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
------
K
VRD
Y
R
----------------------------------
E
----------------------------------------------------
A
Y
-------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
---
P
N
G
I
K
V
-
I
D
D
E
E
V
-
K
R
L
I
R
E
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
---
G
M
-
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
67.18
21%
5
- C1 -
3OSN
6
POLI_HUMAN
A:
[25-414]
-----------------------------------------------------------------
A
S
S
R
V
I
V
H
V
D
L
D
C
F
Y
A
Q
V
E
M
I
S
N
-
P
E
L
-------
K
--
D
K
P
L
G
V
Q
Q
-------
K
Y
L
V
V
T
C
N
Y
E
A
R
K
-
L
G
V
K
K
L
M
N
V
-
R
D
A
K
E
-
K
C
P
Q
L
V
L
V
N
-------
G
E
D
L
T
-
R
Y
R
E
M
S
Y
K
V
T
E
L
L
E
E
F
S
P
--
V
V
E
R
L
G
F
D
E
N
F
V
D
L
T
E
------
M
V
E
K
R
L
Q
Q
LQSDELSA
V
T
V
S
G
HVYNN
Q
S
I
N
LLD
V
L
H
I
R
L
L
V
----------------------------------------------------
G
S
-------------------------
Q
I
A
A
E
M
R
E
A
M
Y
N
Q
L
G
L
T
G
C
A
G
V
A
S
N
K
L
L
A
K
L
V
S
G
V
F
K
P
---
N
Q
Q
T
V
-
L
L
P
E
S
C
Q
H
L
I
H
S
-
L
N
H
I
K
E
I
P
G
I
G
Y
K
T
A
K
-
C
L
E
A
L
G
I
N
S
V
R
D
L
Q
T
F
S
P
K
I
L
E
K
E
L
G
I
S
V
A
Q
R
I
Q
K
L
S
F
G
E
D
N
S
P
V
I
L
S
---
G
P
P
Q
S
F
S
E
E
D
S
F
K
K
---
C
S
S
E
V
E
A
K
N
K
I
E
E
L
L
A
S
L
L
N
R
V
C
Q
D
----
G
--
R
K
P
----
H
T
V
R
L
I
I
R
R
Y
S
S
E
K
H
Y
G
R
--
E
S
R
Q
C
P
I
P
--
S
H
VIQK---
Y
D
V
M
T
P
M
V
D
I
L
M
K
L
F
R
---
N
M
V
--
N
VKM--
P
F
H
L
T
L
L
S
V
C
F
C
N
L
K
------------------------------------------------------------
6
PsiBlast_PDB
66.06
25%
0
- C1 -
4IRD
5
DPO4_ECOLI
F:
[3-274]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
---
A
V
E
M
R
D
N
P
-------
A
LR
D
I
P
I
A
I
G
G
S
R
E
--
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
--
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
-
C
P
-
H
L
T
L
L
P
-------
G
-
R
F
D
-
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
--
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
------
S
VHCHG----------------------------------
S
----------------------------------------------------
A
T
-------------------------
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
----
P
A
E
V
P
A
F
L
-
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
-
L
R
K
--
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
66.01
25%
-5
- C1 -
4Q44
6
DPO4_ECOLI
A:
[3-274]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
---
A
V
E
M
R
D
N
P
-------
A
LR
D
I
P
I
A
I
G
G
S
R
E
--
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
--
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
-
C
P
-
H
L
T
L
L
P
-------
G
-
R
F
D
-
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
--
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
------
S
VHCHG----------------------------------
S
----------------------------------------------------
A
T
-------------------------
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
----
P
A
E
V
P
A
F
L
-
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
-
L
R
K
--
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
65.54
25%
-3
- C1 -
4Q43
7
DPO4_ECOLI
A:
[3-274]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
---
A
V
E
M
R
D
N
P
-------
A
LR
D
I
P
I
A
I
G
G
S
R
E
--
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
--
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
-
C
P
-
H
L
T
L
L
P
-------
G
-
R
F
D
-
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
--
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
------
S
VHCHG----------------------------------
S
----------------------------------------------------
A
T
-------------------------
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
----
P
A
E
V
P
A
F
L
-
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
-
L
R
K
--
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
65.49
21%
-15
- C1 -
4F50
3
DPO4_SULAC (first)
A:
[2-342]
---------------------------------------------------------------------
I
V
I
F
V
D
F
D
Y
F
F
A
Q
V
E
E
V
L
N
-
P
Q
Y
-------
K
--
G
K
P
L
V
V
C
V
Y
S
-----
S
G
A
V
A
T
A
N
Y
E
A
R
K
-
L
G
V
K
A
G
M
P
I
-
I
K
A
M
Q
-
I
A
P
S
A
I
Y
V
P
-------
M
-
R
K
P
-
I
Y
E
A
F
S
N
R
I
M
N
L
L
N
K
H
A
D
--
K
I
E
V
A
S
I
D
E
A
Y
L
D
V
T
N
KVEGN
F
E
---------------------------------------
N
----------------------------------------------------
G
I
-------------------------
E
L
A
R
K
I
K
Q
E
I
L
E
K
E
K
I
T
V
T
V
G
V
A
P
N
K
I
L
A
K
I
I
A
D
K
S
K
P
---
N
G
L
G
V
-
I
R
P
T
E
V
Q
D
F
L
N
E
-
L
-
D
I
D
E
I
P
G
I
G
S
V
L
A
R
-
R
L
N
E
L
G
I
Q
K
L
R
D
I
L
S
K
N
Y
N
E
L
E
K
I
T
G
K
A
K
A
L
Y
L
L
K
L
A
Q
N
K
Y
S
E
P
V
E
N
K
---
S
-
K
I
P
H
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
--------
I
P
----
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
--
V
S
R
G
R
T
F
P
--
H
G
----
I
S
K
----
E
T
A
Y
S
E
S
V
K
L
L
Q
---
K
I
L
--
E
E
D---
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
------------------------------------------------------------
5
PsiBlast_PDB
65.48
25%
-5
- C1 -
4IRC
5
DPO4_ECOLI
F:
[3-274]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
---
A
V
E
M
R
D
N
P
-------
A
LR
D
I
P
I
A
I
G
G
S
R
E
--
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
--
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
-
C
P
-
H
L
T
L
L
P
-------
G
-
R
F
D
-
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
--
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
------
S
VHCHG----------------------------------
S
----------------------------------------------------
A
T
-------------------------
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
----
P
A
E
V
P
A
F
L
-
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
-
L
R
K
--
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
65.08
25%
2
- C1 -
4R8U
4
DPO4_ECOLI
A:
[2-273]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
---
A
V
E
M
R
D
N
P
-------
A
LR
D
I
P
I
A
I
G
G
S
R
E
--
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
--
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
-
C
P
-
H
L
T
L
L
P
-------
G
-
R
F
D
-
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
--
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
------
S
VHCHG----------------------------------
S
----------------------------------------------------
A
T
-------------------------
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
----
P
A
E
V
P
A
F
L
-
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
-
L
R
K
--
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
64.80
25%
3
- C1 -
4IR9
5
DPO4_ECOLI
F:
[3-274]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
---
A
V
E
M
R
D
N
P
-------
A
LR
D
I
P
I
A
I
G
G
S
R
E
--
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
--
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
-
C
P
-
H
L
T
L
L
P
-------
G
-
R
F
D
-
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
--
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
------
S
VHCHG----------------------------------
S
----------------------------------------------------
A
T
-------------------------
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
----
P
A
E
V
P
A
F
L
-
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
-
L
R
K
--
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
64.53
22%
17
* C1 *
4TQR
7
DPO4_SULSO
A:
[2-342]
---------------------------------------------------------------------
I
V
L
F
V
D
F
D
Y
F
Y
A
Q
V
E
E
V
L
N
-
P
S
L
-------
K
--
G
K
P
V
V
V
C
V
F
S
G
RF
E
D
S
G
A
V
A
T
A
N
Y
E
A
R
K
-
F
G
V
K
A
G
I
P
I
-
V
E
A
K
K
-
I
L
P
N
A
V
Y
L
P
-------
M
-
R
K
E
-
V
Y
Q
Q
V
S
S
R
I
M
N
L
L
R
E
Y
S
E
--
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
S
D
KVRD
Y
-
R
---------------------------------------
E
----------------------------------------------------
A
Y
-------------------------
N
L
G
L
E
I
K
N
K
I
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
P
---
N
G
I
K
V
-
I
D
D
E
E
V
K
R
L
I
R
E
-
L
-
D
I
A
D
V
P
G
I
G
N
I
T
A
E
-
K
L
K
K
L
G
I
N
K
L
V
D
T
L
S
I
E
F
D
K
L
K
G
M
I
G
E
A
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
----
R
V
R
K
S
I
G
R
I
V
T
M
K
R
N
--
S
R
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
Y
Y
K
L
D
K
R
----
I
----
P
----
K
A
I
H
V
V
A
V
T
E
D
L
----
D
I
--
V
S
R
G
R
T
F
P
--
H
G
----
I
S
K
----
E
T
A
Y
S
E
S
V
K
L
L
Q
---
K
I
L
E
E
D
-----
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
E
-----------------------------------------------------------
7
PsiBlast_PDB
64.36
25%
-1
- C1 -
4IRK
5
DPO4_ECOLI
B:
[3-274]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
---
A
V
E
M
R
D
N
P
-------
A
LR
D
I
P
I
A
I
G
G
S
R
E
--
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
--
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
-
C
P
-
H
L
T
L
L
P
-------
G
-
R
F
D
-
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
--
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
------
S
VHCHG----------------------------------
S
----------------------------------------------------
A
T
-------------------------
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
----
P
A
E
V
P
A
F
L
-
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
-
L
R
K
--
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
64.34
24%
21
- C1 -
4F4Y
5
DPO4_SULAC (first)
A:
[3-341]
----------------------------------------------------------------------
V
I
F
V
D
F
D
Y
F
F
A
Q
V
E
E
V
---
L
N
P
QYKG
K
P
L
V
--
V
C
V
Y
S
--
G
R
T
K
--
T
S
G
A
V
A
T
A
N
Y
E
A
R
K
--
L
G
V
K
A
G
M
P
I
-
I
K
A
M
Q
-
I
A
-
P
S
A
I
Y
V
-------
P
-
M
R
K
P
I
Y
E
A
F
S
N
R
I
M
N
L
L
N
K
H
A
D
K
--
I
E
V
A
S
I
D
E
A
Y
L
D
V
T
N
KVEGN
F
E
---------------------------------------
N
----------------------------------------------------
G
I
-------------------------
E
L
A
R
K
I
K
Q
E
I
L
E
K
E
K
I
T
V
T
V
G
V
A
P
N
K
I
L
A
K
I
I
A
D
-
K
S
K
P
N
G
L
G
V
I
R
P
T
E
V
Q
D
F
L
N
E
L
-----
D
I
D
E
I
P
G
I
G
S
V
L
A
R
-
R
L
N
E
L
G
I
Q
K
L
R
D
I
L
S
K
N
Y
N
E
L
E
K
---
I
-
T
G
K
A
K
A
L
Y
L
L
K
L
A
Q
D
E
Y
N
E
P
I
R
T
R
V
R
K
S
I
G
R
Y
L
T
L
P
Y
N
-----
T
R
D
V
K
V
I
L
P
Y
L
K
K
A
I
---
N
E
A
Y
----
N
--
K
V
N
GIPM
R
I
T
V
I
A
I
M
E
D
L
D
I
L
-
S
K
G
K
K
F
K
H
G
I
S
I
D
--
N
A
----
Y
K
V
A
---
E
D
L
L
R
E
L
L
V
R
D
K
---
R
-----------
R
N
V
R
R
I
G
V
K
L
D
N
I
-------------------------------------------------------------
2
PsiBlast_PDB
63.74
25%
4
- C1 -
4IR1
5
DPO4_ECOLI
F:
[3-274]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
---
A
V
E
M
R
D
N
P
-------
A
LR
D
I
P
I
A
I
G
G
S
R
E
--
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
--
F
G
V
R
S
A
M
P
T
G
M
A
L
K
L
-
C
P
-
H
L
T
L
L
P
-------
G
-
R
F
D
-
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
--
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
------
S
VHCHG----------------------------------
S
----------------------------------------------------
A
T
-------------------------
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
----
P
A
E
V
P
A
F
L
-
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
K
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
-
L
R
K
--
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
63.41
25%
-1
- C1 -
4Q45
5
DPO4_ECOLI
F:
[3-274]
--------------------------------------------------------------------
R
K
I
I
H
V
D
M
D
C
F
F
A
---
A
V
E
M
R
D
N
P
-------
A
LR
D
I
P
I
A
I
G
G
S
R
E
--
R
R
G
V
I
S
T
A
N
Y
P
A
R
K
--
F
G
V
R
S
A
M
P
T
G
M
A
L
A
L
-
C
P
-
H
L
T
L
L
P
-------
G
-
R
F
D
-
A
Y
K
E
A
S
N
H
I
R
E
I
F
S
R
Y
T
S
R
--
I
E
P
L
S
L
D
E
A
Y
L
D
V
T
D
------
S
VHCHG----------------------------------
S
----------------------------------------------------
A
T
-------------------------
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
P
N
G
Q
F
V
I
T
----
P
A
E
V
P
A
F
L
-
Q
T
L
-
P
L
A
K
I
P
G
V
G
K
V
S
A
A
-
K
L
E
A
M
G
L
R
T
C
G
D
V
Q
A
C
D
L
V
M
L
L
K
R
F
G
K
-
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
E
R
-
L
R
K
--
S
V
G
V
E
R
T
M
A
E
D
--
I
H
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
E
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------