@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22170: (2016-07-04 )
MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALAICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKSTLASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTGLHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAPGFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEAGLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTWSVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA
Atome Classification :
(20 SA)
.........10........20....----.-.-.---.----30---...------......40-------------....-------------....50........60.....---------...---------70........80........90....-....-100-...-.....110.......120.......130-........140.......150......-.-160.......170.......180.......190.......200.......210.......220.-......230.......240.......---250...---....260.......270.......280.......290..-----.--.---.---..300.......310.---------------------.---------------.---------------------.----...320.......-330--.--........340..--....---.350--........360.......370.......380...----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
K
Y
T
L
I
ATAPM
G
I
E
A
V
V
A
K
E
V
R
DL----G-
Y
-
E
---
C
----K----VDN------
G
K
V
I
FEGD-------------
A
L
A
I
-------------
C
RA
N
L
W
L
RTA
D
R
I
K
V
Q
V
A
SF
K
---------
A
K
T
---------
F
D
E
L
F
E
K
T
KAI
N
W
R
SFIPENGKFPVI-
G
K
S
V
-
K
-
S
-
T
L
A-SVP
D
C
Q
R
I
V
K
K
A
I
V
E
K
L
KLQSGKAND
W
--
I
E
ETGA
E
Y
K
V
E
I
S
L
LKD
Q
A
L
I
T
LDSSG-T-GLHKRGYRVDQGGA
P
I
K
E
T
L
A
A
A
L
V
Q
LTNWTPDRPFVDPFCGS
G
T
I
A
I
E
A
A
LIGQNIAPGFN
R
D
-
F
V
S
E
D
W
E
W
I
G
K
D
L
W
N
K
A
R
L
E
V
E
EKAN---YDQ
P
L
T
---
I
F
A
SD
I
D
H
R
M
V
Q
I
A
K
EN
A
E
EAG
L
G
D
L
I
Q
F
K
Q
M
Q
V
K
DFTT-----N--L---
E
---
F
G
V
I
VGNP
P
Y
G
E
RLG
E
---------------------
K
---------------
K
---------------------
A
----
V
E
Q
M
Y
K
E
M
G
Q
AFE-P----L--D
T
W
S
V
Y
M
L
TSNE
N
--
F
E
E
A
---YGR---KA
T
K
K
R
K
L
F
N
G
F
IK
T
D
Y
Y
Q
Y
W
S
KVRPQRKKTENA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
92.52
63%
-99
- C2 -
3K0B
2
?
A:
[13-384]
-
K
S
F
Q
L
V
A
T
A
A
S
G
L
E
A
I
V
G
K
E
V
A
R
L
----
G
-
Y
-
D
---
P
----
K
----
V
E
N
------
G
K
V
Y
F
E
G
D
-------------
L
S
A
I
-------------
A
R
A
N
L
W
L
R
V
A
D
R
V
K
I
V
V
G
V
F
K
---------
A
T
T
---------
F
D
E
L
F
E
K
T
K
A
L
P
W
E
D
Y
L
P
L
D
A
Q
F
P
V
A
-
G
K
S
V
-
K
-
S
-
T
L
Y
-
S
V
P
D
C
Q
A
I
V
K
K
A
I
V
N
R
V
S
E
K
Y
R
R
S
G
R
---
L
M
E
T
G
A
L
F
K
L
E
V
S
I
L
K
D
E
V
T
L
T
I
D
T
S
G
-
A
-
G
L
H
K
R
G
Y
R
L
A
Q
G
S
A
P
I
K
E
T
M
A
A
A
L
V
L
L
T
S
W
H
P
D
R
P
F
Y
D
P
V
C
G
S
G
T
I
P
I
E
A
A
L
I
G
Q
N
I
A
P
G
F
N
R
E
-
F
V
S
E
T
W
D
W
M
P
K
Q
V
W
A
D
A
R
Q
E
A
E
D
L
A
N
---
Y
D
Q
P
L
N
---
I
I
G
G
D
I
D
A
R
L
I
E
I
A
K
Q
N
A
V
E
A
G
L
G
D
L
I
T
F
R
Q
L
Q
V
A
D
F
Q
T
-----
E
--
D
---
E
---
Y
G
V
V
V
A
N
P
P
Y
G
E
R
L
E
D
---------------------
E
---------------
E
---------------------
A
----
V
R
Q
L
Y
R
E
M
G
I
V
Y
K
-
R
----
M
--
P
T
W
S
V
Y
V
L
T
S
Y
E
L
--
F
E
E
V
---
Y
G
K
---
K
A
T
K
K
R
K
L
Y
----
R
T
D
L
Y
Q
Y
W
G
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
85.64
63%
-16
- C2 -
3K0B
2
?
A:
[12-384]
M
K
S
F
Q
L
V
A
T
A
A
S
G
L
E
A
I
V
G
K
E
V
A
R
L
----
G
-
Y
-
D
---
P
----
K
----
V
E
N
------
G
K
V
Y
F
E
G
D
-------------
L
S
A
I
-------------
A
R
A
N
L
W
L
R
V
A
D
R
V
K
I
V
V
G
V
F
K
---------
A
T
T
---------
F
D
E
L
F
E
K
T
K
A
L
P
W
E
D
Y
L
P
L
D
A
Q
F
P
V
A
-
G
K
S
V
-
K
-
S
-
T
L
Y
S
V
P
-
D
C
Q
A
I
V
K
K
A
I
V
N
R
V
S
E
K
Y
R
R
S
G
-
R
--
L
M
E
T
G
A
L
F
K
L
E
V
S
I
L
K
D
E
V
T
L
T
I
D
T
S
G
-
A
-
G
L
H
K
R
G
Y
R
L
A
Q
G
S
A
P
I
K
E
T
M
A
A
A
L
V
L
L
T
S
W
H
P
D
R
P
F
Y
D
P
V
C
G
S
G
T
I
P
I
E
A
A
L
I
G
Q
N
I
A
P
G
F
N
R
E
-
F
V
S
E
T
W
D
W
M
P
K
Q
V
W
A
D
A
R
Q
E
A
E
D
L
A
N
---
Y
D
Q
P
L
N
---
I
I
G
G
D
I
D
A
R
L
I
E
I
A
K
Q
N
A
V
E
A
G
L
G
D
L
I
T
F
R
Q
L
Q
V
A
D
F
Q
T
-----
E
--
D
---
E
---
Y
G
V
V
V
A
N
P
P
Y
G
E
R
L
E
D
---------------------
E
---------------
E
---------------------
A
----
V
R
Q
L
Y
R
E
M
G
I
V
Y
K
-
R
----
M
--
P
T
W
S
V
Y
V
L
T
S
Y
E
L
--
F
E
E
V
---
Y
G
K
---
K
A
T
K
K
R
K
L
Y
----
R
T
D
L
Y
Q
Y
W
G
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.71
52%
-4
- C2 -
3LDG
1
?
A:
[3-377]
-
K
T
F
N
L
V
A
T
A
A
A
G
I
E
A
V
V
G
K
E
L
R
N
L
----
G
-
L
-
D
---
C
----
Q
----
V
E
N
------
G
R
V
L
F
K
G
N
-------------
I
E
T
I
-------------
A
K
S
N
L
W
L
R
S
A
D
R
I
K
I
V
V
G
E
F
P
---------
A
R
T
---------
F
E
E
L
F
Q
G
V
Y
A
L
D
W
E
N
Y
L
P
L
G
C
Q
F
P
V
A
K
A
K
S
V
-
K
-
S
-
K
L
H
-
N
E
P
S
I
Q
G
I
T
K
K
A
I
V
K
K
L
Q
H
Y
F
H
R
P
D
S
V
P-
L
P
E
N
G
P
E
F
K
I
E
I
S
L
L
K
D
Q
A
R
V
M
I
D
T
T
G
-
P
-
S
L
F
K
R
G
Y
R
T
E
---
A
P
I
K
E
N
M
A
A
A
I
I
L
L
S
N
W
F
P
D
K
P
F
V
D
P
T
C
G
S
G
T
F
C
I
E
A
A
M
I
G
M
N
I
A
P
G
F
N
R
D
-
F
A
F
E
E
W
P
W
V
D
E
A
L
V
T
R
V
R
N
E
A
D
E
Q
A
D
---
Y
D
I
Q
L
D
---
I
S
G
F
D
F
D
G
R
M
V
E
I
A
R
K
N
A
R
E
V
G
L
E
D
V
V
K
L
K
Q
M
R
L
Q
D
F
K
T
-----
N
--
K
---
I
---
N
G
V
L
I
S
N
P
P
Y
G
E
R
L
L
D
---------------------
D
---------------
K
---------------------
A
----
V
D
I
L
Y
N
E
M
G
E
T
F
A
-
P
----
L
--
K
T
W
S
Q
F
I
L
T
N
D
T
D
--
F
E
Q
K
---
F
G
R
---
K
A
D
K
K
R
K
L
Y
N
G
S
L
K
V
D
L
Y
Q
F
Y
G
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
78.85
53%
7
* C2 *
3LDG
1
?
A:
[3-377]
-
K
T
F
N
L
V
A
T
A
A
A
G
I
E
A
V
V
G
K
E
L
R
N
L
----
G
-
L
-
D
---
C
----
Q
----
V
E
N
------
G
R
V
L
F
K
G
N
-------------
I
E
T
I
-------------
A
K
S
N
L
W
L
R
S
A
D
R
I
K
I
V
V
G
E
F
P
---------
A
R
T
---------
F
E
E
L
F
Q
G
V
Y
A
L
D
W
E
N
Y
L
P
L
G
C
Q
F
P
V
A
-
K
A
K
S
V
K
-
S
-
K
L
H
N
E
P
-
S
I
Q
G
I
T
K
K
A
I
V
K
K
L
Q
H
Y
F
H
R
P
D
-
S
VP
L
P
E
N
G
P
E
F
K
I
E
I
S
L
L
K
D
Q
A
R
V
M
I
D
T
T
G
-
P
-
S
L
F
K
R
G
Y
R
T
E
---
A
P
I
K
E
N
M
A
A
A
I
I
L
L
S
N
W
F
P
D
K
P
F
V
D
P
T
C
G
S
G
T
F
C
I
E
A
A
M
I
G
M
N
I
A
P
G
F
N
R
D
-
F
A
F
E
E
W
P
W
V
D
E
A
L
V
T
R
V
R
N
E
A
D
E
Q
A
D
---
Y
D
I
Q
L
D
---
I
S
G
F
D
F
D
G
R
M
V
E
I
A
R
K
N
A
R
E
V
G
L
E
D
V
V
K
L
K
Q
M
R
L
Q
D
F
K
T
-----
N
--
K
---
I
---
N
G
V
L
I
S
N
P
P
Y
G
E
R
L
L
D
---------------------
D
---------------
K
---------------------
A
----
V
D
I
L
Y
N
E
M
G
E
T
F
A
-
P
----
L
--
K
T
W
S
Q
F
I
L
T
N
D
T
D
--
F
E
Q
K
---
F
G
R
---
K
A
D
K
K
R
K
L
Y
N
G
S
L
K
V
D
L
Y
Q
F
Y
G
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
73.73
46%
37
- C2 -
3LDU
12
?
A:
[5-383]
-
K
N
Y
T
L
I
S
P
C
F
F
G
M
E
K
M
L
A
R
E
I
T
N
L
----
G
-
Y
-
E
---
I
I---
K
----
T
E
D
------
G
R
I
T
Y
K
T
D
-------------
E
F
G
I
-------------
A
K
S
N
M
W
L
R
C
A
E
R
V
H
L
K
I
A
E
F
E
---------
A
K
S
---------
F
D
E
L
F
E
N
T
K
R
I
N
W
S
R
Y
I
P
Y
G
A
Q
F
P
I
S
K
A
S
S
I
-
K
-
S
-
K
L
Y
-
S
T
P
D
V
Q
A
I
V
K
K
A
I
V
E
S
L
K
-
K
S
Y
L
E
D
G
L
--
L
K
E
D
K
E
K
Y
P
I
F
V
F
I
H
K
D
K
V
T
I
S
I
D
T
T
G
-
D
-
A
L
H
K
R
G
Y
R
E
K
--
K
A
P
I
R
E
T
L
A
A
G
L
I
Y
L
T
P
W
K
A
G
R
V
L
V
D
P
M
C
G
S
G
T
I
L
I
E
A
A
M
I
G
I
N
M
A
P
G
L
N
R
E
-
F
I
S
E
K
W
R
T
L
D
K
K
I
W
W
D
V
R
K
D
A
F
N
K
I
D
---
N
E
S
K
F
K
---
I
Y
G
Y
D
I
D
E
E
S
I
D
I
A
R
E
N
A
E
I
A
G
V
D
E
Y
I
E
F
N
V
G
D
A
T
Q
F
K
S
-----
E
--
D
---
E
---
F
G
F
I
I
T
N
P
P
Y
G
E
R
L
E
D
---------------------
K
---------------
D
---------------------
S
----
V
K
Q
L
Y
K
E
L
G
Y
A
F
R
-
K
----
L
--
K
N
W
S
Y
Y
L
I
T
S
Y
E
D
--
F
E
Y
E
---
F
G
Q
---
K
A
D
K
K
R
K
L
Y
N
G
M
L
K
T
N
F
F
Q
Y
P
G
P
K
P
P
R
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
73.49
47%
30
- C2 -
3LDU
12
?
A:
[5-381]
-
K
N
Y
T
L
I
S
P
C
F
F
G
M
E
K
M
L
A
R
E
I
T
N
L
----
G
-
Y
-
E
I--
I
----
K
----
T
E
D
------
G
R
I
T
Y
K
T
D
-------------
E
F
G
I
-------------
A
K
S
N
M
W
L
R
C
A
E
R
V
H
L
K
I
A
E
F
E
---------
A
K
S
---------
F
D
E
L
F
E
N
T
K
R
I
N
W
S
R
Y
I
P
Y
G
A
Q
F
P
I
S
-
K
A
S
S
I
K
-
S
-
K
L
Y
S
T
P
-
D
V
Q
A
I
V
K
K
A
I
V
E
S
L
K
K
S
Y
L
E
D
G
-
L
--
L
K
E
D
K
E
K
Y
P
I
F
V
F
I
H
K
D
K
V
T
I
S
I
D
T
T
G
-
D
-
A
L
H
K
R
G
Y
R
E
K
--
K
A
P
I
R
E
T
L
A
A
G
L
I
Y
L
T
P
W
K
A
G
R
V
L
V
D
P
M
C
G
S
G
T
I
L
I
E
A
A
M
I
G
I
N
M
A
P
G
L
N
R
E
-
F
I
S
E
K
W
R
T
L
D
K
K
I
W
W
D
V
R
K
D
A
F
N
K
I
D
---
N
E
S
K
F
K
---
I
Y
G
Y
D
I
D
E
E
S
I
D
I
A
R
E
N
A
E
I
A
G
V
D
E
Y
I
E
F
N
V
G
D
A
T
Q
F
K
S
-----
E
--
D
---
E
---
F
G
F
I
I
T
N
P
P
Y
G
E
R
L
E
D
---------------------
K
---------------
D
---------------------
S
----
V
K
Q
L
Y
K
E
L
G
Y
A
F
R
-
K
----
L
--
K
N
W
S
Y
Y
L
I
T
S
Y
E
D
--
F
E
Y
E
---
F
G
Q
---
K
A
D
K
K
R
K
L
Y
N
G
M
L
K
T
N
F
F
Q
Y
P
G
P
K
P
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
65.99
32%
-25
- C2 -
3V97
3
RLMKL_ECOLI
A:
[28-402]
---------------------------------
E
---
C
----
Q
----
V
V
Q
------
G
G
V
H
F
K
G
D
-------------
T
R
L
V
-------------
Y
Q
S
L
M
W
S
R
L
A
S
R
I
M
L
P
L
G
E
C
K
---------
V
Y
S
---------
D
L
D
L
Y
L
G
V
Q
A
I
N
W
T
E
M
F
N
P
G
A
T
F
A
V
H
-
F
S
G
L
-
N
-
D
-
T
I
R
-
N
S
Q
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
R
K
N
L
P
R
P
N
---
V
D
R
D
A
P
D
I
R
V
N
V
W
L
H
K
E
T
A
S
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
R
A
G
I
A
P
I
K
E
T
L
A
A
A
I
V
M
R
S
G
W
Q
P
G
T
P
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
G
R
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
Y
S
S
H
---
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
I
G
E
L
I
T
F
E
V
K
D
V
A
Q
L
T
N
-----
P
--
L
PKG
P
---
Y
G
T
V
L
S
N
P
P
Y
G
E
---
S
---------------------
E
---------------
P
---------------------
A
----
L
I
A
L
H
S
L
L
G
R
I
M
K
N
Q
----
F
--
G
G
W
N
L
S
L
F
S
A
S
P
D
--
L
L
S
C
---
L
Q
L
---
R
A
D
K
Q
Y
K
A
K
N
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
65.76
31%
23
- C2 -
3V97
6
RLMKL_ECOLI
A:
[1-703]
-
A
M
N
S
L
F
A
S
T
A
R
G
L
E
E
L
L
K
T
E
L
E
N
L
----
G
A
V
-
E
---
C
----
Q
----
V
V
Q
------
G
G
V
H
F
K
G
D
-------------
T
R
L
V
-------------
Y
Q
S
L
M
W
S
R
L
A
S
R
I
M
L
P
L
G
E
C
K
---------
V
Y
S
---------
D
L
D
L
Y
L
G
V
Q
A
I
N
W
T
E
M
F
N
P
G
A
T
F
A
V
H
-
F
S
G
L
-
N
-
D
-
T
I
R
-
N
S
Q
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
-
R
K
N
L
P
R
P
N
--
V
D
R
D
A
P
D
I
R
V
N
V
W
L
H
K
E
T
A
S
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
R
A
G
I
A
P
I
K
E
T
L
A
A
A
I
V
M
R
S
G
W
Q
P
G
T
P
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
G
R
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
---
K
G
L
A
E
Y
S
S
H
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
I
G
E
L
I
T
F
E
V
K
D
V
A
Q
L
T
N
-----
P
--
L
---
P
KGP
Y
G
T
V
L
S
N
P
P
Y
G
E
---
S
---------------------
E
---------------
P
---------------------
A
----
L
I
A
L
H
S
L
L
G
R
I
M
K
-
N
Q---
F
--
G
G
W
N
L
S
L
F
S
A
S
P
D
--
L
L
S
C
---
L
Q
L
---
R
A
D
K
Q
Y
K
A
K
N
G
--
P
L
D
C
V
Q
K
N
Y
H
V
A
E
S
M
V
A
E
D
Y
T
N
R
L
R
K
N
L
K
K
F
E
K
W
A
R
Q
E
GIECYRLYDADLPEYN
V
A
V
D
R
Y
AD
W
V
V
V
Q
E
Y
AH
K
A
R
Q
R
L
F
D
I
I
A
A
T
I
S
V
L
GIAPNK
L
V
L
K
T
REE
K
G
E
F
L
E
V
T
E
YN
A
H
L
W
V
N
LTDYLDTGLFLDH
R
I
A
R
R
M
L
G
Q
M
SKGKD
F
L
N
L
FSYTG
S
A
T
V
H
A
G
L
G
GAR
S
T
T
T
V
D
MS
R
T
Y
L
E
W
A
E
R
N
L
R
L
N
GLTGRA
H
R
L
I
Q
A
D
C
L
A
W
L
R
E
ANEQFD
L
I
F
I
D
P
P
TFSAFDVQRD
H
L
A
L
M
K
D
L
K
R
L
LRAG
G
T
I
M
F
S
N
NKRGFRMD
L
D
G
L
A
K
L
G
L
K
A
Q
E
ITQKTLSQDFARNRQIH
N
C
W
L
I
T
AA
21
PsiBlast_CBE
64.17
32%
-32
- C2 -
3V97
3
RLMKL_ECOLI
B:
[28-405]
---------------------------------
E
---
C
----
Q
----
V
V
Q
------
G
G
V
H
F
K
G
D
-------------
T
R
L
V
-------------
Y
Q
S
L
M
W
S
R
L
A
S
R
I
M
L
P
L
G
E
C
K
---------
V
Y
S
---------
D
L
D
L
Y
L
G
V
Q
A
I
N
W
T
E
M
F
N
P
G
A
T
F
A
V
H
------------
R
-
N
S
Q
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
R
---
P
R
P
N
---
V
D
R
D
A
P
D
I
R
V
N
V
W
------
S
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
---
I
A
P
I
K
E
T
L
A
A
A
I
V
M
R
S
G
W
Q
P
G
T
P
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
G
R
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
Y
S
S
H
---
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
I
G
E
L
I
T
F
E
V
K
D
V
A
Q
L
T
N
-----
P
--
L
PKG
P
---
Y
G
T
V
L
S
N
P
P
Y
-----
S
---------------------
E
---------------
P
---------------------
A
----
L
I
A
L
H
S
L
L
G
R
I
M
K
N
Q
----
F
--
G
G
W
N
L
S
L
F
S
A
S
P
D
--
L
L
S
C
---
L
Q
L
---
R
A
D
K
Q
Y
K
A
K
N
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
62.81
32%
-33
- C2 -
3V8V
2
RLMKL_ECOLI
B:
[27-405]
---------------------------------
E
---
C
----
Q
----
V
V
Q
------
G
G
V
H
F
K
G
D
-------------
T
R
L
V
-------------
Y
Q
S
L
M
W
S
R
L
A
S
R
I
M
L
P
L
G
E
C
-----------
Y
S
---------
D
L
D
L
Y
L
G
V
Q
A
I
N
W
T
E
M
F
N
P
G
A
T
F
A
V
H
------------
R
-
N
S
Q
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
R
---
P
R
P
N
---
V
D
R
D
A
P
D
I
R
V
N
V
W
-------
I
A
L
D
L
S
G
-
D
-
G
L
H
L
R
G
Y
R
D
----
A
P
I
K
E
T
L
A
A
A
I
V
M
R
S
G
W
Q
P
G
T
P
L
L
D
P
M
C
G
S
G
T
L
L
I
E
A
A
M
L
A
T
D
R
A
P
G
L
H
R
G
R
W
G
F
S
G
W
A
Q
H
D
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
Y
S
S
H
---
F
Y
G
S
D
S
D
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
G
I
G
E
L
I
T
F
E
V
K
D
V
A
Q
L
T
N
-----
P
--
L
PK
G
P
---
Y
G
T
V
L
S
N
P
P
Y
-----
S
---------------------
E
---------------
P
---------------------
A
----
L
I
A
L
H
S
L
L
G
R
I
M
K
N
Q
----
F
--
G
G
W
N
L
S
L
F
S
A
S
P
D
--
L
L
S
C
---
L
Q
L
---
R
A
D
K
Q
Y
K
A
K
N
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
55.45
23%
-0
- C2 -
3TM4
1
?
A:
[1-370]
---
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
E
V
S
L
L
L
K
K
L
G
-
I
-
S
---
F
----
Q
----
I
E
E
KPLGIE
G
R
L
L
L
E
A
E
-------------
K
A
Y
Y
V
D
EKG
R
K
R
E
L
S
I
S
T
Y
L
N
E
N
S
R
L
L
H
R
V
I
I
E
I
A
S
E
K
FNGIEKDE
S
E
E
A
---------
L
K
R
I
K
D
F
V
S
S
L
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
R
-
S
F
R
K
-
G
-
D
-
H
N
I
-
T
S
I
D
I
A
R
T
V
G
E
A
I
F
E
R
L
S
---
R
F
G
T
P
L
--
V
N
L
D
H
P
A
V
I
F
R
A
E
L
I
K
D
V
F
F
L
G
I
D
T
T
G
D
S
-
S
L
H
K
R
P
W
R
V
Y
D
H
P
A
H
L
K
A
S
I
A
N
A
M
I
E
L
A
E
L
D
G
G
-
S
V
L
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
R
R
Y
S
G
------------------------------------------
E
---
I
I
G
I
E
K
Y
R
K
H
L
I
G
A
E
M
N
A
L
A
A
G
V
L
D
K
I
K
F
I
Q
G
D
A
T
Q
L
S
Q
-----
Y
--
V
---
D
S--
V
D
F
A
I
S
N
L
P
Y
G
S
--
M
I
---------------------
P
---------------
D
---------------------
L
----
Y
M
K
F
F
N
E
L
A
K
V
--------
L
--
E
K
R
G
V
F
I
T
T
E
K
K
A
--
I
E
E
A
---
I
A
E
N
GF
E
I
I
H
H
R
V
I
G
H
G
G
L
M
V
H
L
Y
V
V
K
L
E
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
52.67
23%
18
- C2 -
3TMA
1
?
A:
[19-353]
--
H
M
W
L
E
A
T
T
H
P
G
L
E
D
L
L
L
E
E
L
S
A
L
----
Y
-
P
G
E
GAE
V
----
D
----
A
R
K
------
G
R
V
R
I
P
R
A
-------------
W
V
---------------
G
E
E
A
L
G
L
R
L
A
H
H
L
V
L
F
R
A
R
L
L
LSR------
E
D
P
---------
L
G
A
L
E
R
A
A
L
A
L
P
W
P
E
L
E
G
-
A
G
S
F
R
V
E
-
A
R
R
E
-
G
-
E
H
P
F
T
-
S
P
-
E
V
E
R
R
V
G
E
A
L
H
R
A
Y
G
V
-------
P
--
V
D
L
K
R
P
A
V
R
V
R
V
D
V
R
G
E
E
A
F
L
G
V
Q
L
T
E
-
R
-
P
L
S
R
R
F
P
K
A
-
A
L
R
G
S
L
T
P
V
L
A
Q
A
L
L
R
L
A
D
A
R
P
G
M
R
V
L
D
P
F
T
G
S
G
T
I
A
L
E
A
A
S
T
L
G
P
-----------------------------------------
T
S
P
---
V
Y
A
G
D
L
D
E
K
R
L
G
L
A
R
E
A
A
L
A
S
G
L
S
-
W
I
R
F
L
R
A
D
A
R
H
L
P
R
-----
F
--
F
P--
E
---
V
D
R
I
L
A
N
P
P
H
G
L
-------------------------
K
---------------
E
---------------------
G
----
L
F
H
L
Y
W
D
F
L
R
G
A
L
-
A
----
L
LP
P
G
G
R
V
A
L
L
T
L
R
P
A
--
L
L
K
R
A
LP
P
G
F
---
A
L
R
H
A
R
V
V
E
Q
G
G
V
Y
P
R
V
F
V
L
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
51.24
23%
21
- C2 -
3TM4
1
?
A:
[1-366]
---
M
K
F
L
L
T
T
A
Q
G
I
E
D
I
A
K
R
E
V
S
L
L
----
L
-
K
K
L
G--
I
S
F
Q
I
E
E
KPL
G
I
E
------
G
R
L
L
L
E
A
E
K
A
Y
Y
V
D
EKG
R
K
R
E
L
S
I
S
-------------
T
Y
L
N
E
N
S
R
L
L
H
R
V
I
I
E
I
A
S
E
K
---------
F
N
G
IEKDE
S
E
E
A
L
K
R
I
K
D
F
V
S
S
L
P
V
E
Q
F
V
K
V
S
E
T
F
A
V
R
-
S
F
R
K
-
G
D
H
-
N
I
T
-
S
I
-
D
I
A
R
T
V
G
E
A
I
F
E
R
L
S
R
F
--
G
T
P
-
L
--
V
N
L
D
H
P
A
V
I
F
R
A
E
L
I
K
D
V
F
F
L
G
I
D
T
T
G
-
D
S
S
L
H
K
R
P
W
R
V
Y
D
H
P
A
H
L
K
A
S
I
A
N
A
M
I
E
L
A
E
L
-
D
G
G
S
V
L
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
R
R
Y
S
------------------------------------------
G
E
---
I
I
G
I
E
K
Y
R
K
H
L
I
G
A
E
M
N
A
L
A
A
G
V
L
D
K
I
K
F
I
Q
G
D
A
T
Q
L
S
Q
-----
Y
--
V
D--
S
---
V
D
F
A
I
S
N
L
P
Y
G
------------------------------------------
S
---------------------
M
----
I
P
D
L
Y
M
K
F
F
N
E
L
A
-
K
----
V
LE
K
R
G
V
F
I
T
T
E
K
K
A
I
E
E
A
I
A
E
---
N
G
F
---
E
I
I
H
H
R
V
I
G
H
G
G
L
M
V
H
L
Y
V
V
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
41.44
21%
-64
- C2 -
1NV8
2
PRMC_THEMA
A:
[108-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
E
L
V
E
L
A
L
E
L
I
R
K
Y
G
I
K
T
V
A
D
I
G
T
G
S
G
A
I
G
V
S
V
A
K
F
S
D
-------------------------------------------
A
I
---
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
R
H
G
V
S
D
R
F
F
V
R
K
G
E
F
L
E
P
F
K
-----
E
KF
A
---
S
---
I
E
M
I
L
S
N
P
P
Y
V
K
S
S
A
H
---------------------
L
PKDVLFEPPEALFGG
E
---------------------
D
----
G
L
D
F
Y
R
E
F
F
G
R
Y
D
---------
T
S
G
K
I
V
L
M
E
I
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
41.02
13%
-95
- C2 -
2IH2
5
MTTA_THEAQ
A:
[21-168]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
T
P
P
E
V
V
D
F
M
V
S
L
A
E
A
P
R
G
G
R
V
L
E
P
A
C
A
H
G
P
F
L
R
A
F
R
E
A
H
G
T
-----------------------------------------
A
Y
R
---
F
V
G
V
E
I
D
P
K
A
L
D
L
P
P
W
----------
A
E
G
I
L
A
D
F
L
L
W
E
P
-----
G
--
E
---
A
---
F
D
L
I
L
G
N
P
P
Y
G
I
V
G
E
A
---------------------
S
---------------
K
YP
I
H
V
F
K
A
V
K
D
L
Y
K
K
A
F
STWK
G
KYN
L
Y
G
A
F
L
E
K
A
V
R
L
L
K
---------
P
G
G
V
L
V
F
V
V
P
A
T
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
40.92
24%
-73
- C2 -
3TMA
-
?
A:
[153-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
R
V
D
V
R
G
E
E
A
F
L
G
V
Q
L
T
E
-
R
-
P
L
S
R
R
F
P
K
A
A
L
R
G
S
-
L
T
P
V
L
A
Q
A
L
L
R
L
A
D
A
R
P
G
M
R
V
L
D
P
F
T
G
S
G
T
I
A
L
E
A
A
S
T
L
G
P
T
S
P
--------------------------------------------
V
Y
A
G
D
L
D
E
K
R
L
G
L
A
R
E
A
A
L
A
S
G
L
-
S
W
I
R
F
L
R
A
D
A
R
H
L
P
R
-----
F
--
F
P--
E
---
V
D
R
I
L
A
N
P
P
H
G
L
-------------------------
K
---------------
E
---------------------
G
----
L
F
H
L
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
40.02
13%
-76
- C2 -
3A25
1
TYW2_PYRHO
A:
[29-301]
-------------
I
K
P
R
I
R
E
I
L
S
K
E
----------------------------------------------------------------------------------------
L
P
---------
E
E
L
---------
V
K
L
L
P
K
R
W
V
R
I
G
D
V
L
L
L
P
L
R
P
E
L
E
P
Y
-
K
H
R
I
-
A
-
E
-
V
Y
A
-
E
V
L
G
V
K
T
V
L
R
K
G
D
Y
E
--
L
L
Y
G
S
D
T
V
T
V
--
H
V
E
N
G
I
K
Y
K
L
D
V
A
K
I
M
----------------------
F
S
P
A
N
V
K
E
R
V
R
M
A
K
V
A
------
K
P
D
E
L
V
V
D
M
F
A
G
I
G
H
L
S
L
P
I
A
V
Y
G
K
-------------------------------------------
A
K
---
V
I
A
I
E
K
D
P
Y
T
F
K
F
L
V
E
N
I
H
L
N
K
V
E
D
R
M
S
A
Y
N
M
D
N
R
D
F
P
G
-----
E
--
N
---
I
---
A
D
R
I
L
M
G
Y
V
--------------------------------------------
V
---------------------
R
----
T
H
E
F
I
P
K
A
L
S
I
A
K
-
D
----
G
--
A
I
I
H
Y
H
N
T
V
P
E
K
L
--
M
P
R
E
---
P
F
E
---
T
F
K
R
I
T
K
E
Y
G
Y
D
V
E
K
L
N
E
L
K
I
K
R
Y
A
P
G
V
W
H
V
V
L
D
L
R
V
F
KS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
39.12
21%
-83
- C2 -
2B3T
1
PRMC_ECOLI
A:
[109-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
C
R
I
L
D
L
G
T
G
T
G
A
I
A
L
A
L
A
S
E
R
P
D
------------------------------------------
C
E
---
I
I
A
V
D
R
M
P
D
A
V
S
L
A
Q
R
N
A
Q
H
L
A
I
K
-
N
I
H
I
L
Q
S
D
W
F
S
A
L
A
-----
G
--
Q
---
Q
---
F
A
M
I
V
S
N
P
P
Y
I
D
E
Q
D
P
H
L
Q
Q
GDVRFEPLTALVAADSG
M
---------------
A
---------------------
D
----
I
V
H
I
I
E
Q
S
R
N
A
L
V
---------
S
G
G
F
L
L
L
E
H
G
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
38.77
30%
-184
- C2 -
3GDH
3
TGS1_HUMAN
A:
[101-155]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
---
V
I
A
I
D
I
D
P
V
K
I
A
L
A
R
N
N
A
E
V
Y
G
I
A
D
K
I
E
F
I
C
G
D
F
L
L
L
A
S
-----
F
--
L
---
K
---
A
D
V
V
F
L
S
P
P
W
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
37.78
15%
-44
- C2 -
3UFB
-
?
A:
[198-367]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
Y
T
P
R
P
V
V
R
F
M
V
E
V
M
D
P
Q
L
G
E
S
V
L
D
P
A
C
G
T
G
G
F
L
V
E
A
F
E
H
L
E
R
Q
C
K
T
---------------
V
E
-----------
D
R
E
---
V
L
Q
E
S
S
---
I
F
G
G
E
A
K
S
L
P
Y
L
L
V
Q
M
N
L
L
L
H
G
L
E
-
Y
P
R
I
D
P
E
N
S
L
R
F
P
L
REMGD
K
--
D
---
R
---
V
D
V
I
L
T
N
P
P
F
G
G
E
E
E
K
---------------------
G
---------------
I
L
G
N
F
PEDMQTAE---------
T
----
A
M
L
F
L
Q
L
I
M
R
K
L
K
-
R
PGHG
S
D-
N
G
G
R
A
A
V
V
V
P
N
G
T
--
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------