@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22370: (2016-07-04 )
MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNTPQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHALYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAITEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSIAQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQYGAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQSCGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKHS
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70........80........90.........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280..--..--.--..290-.......300.......310.......320.......330.......340....-...350.......360.--...--...370.......380.......390.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
L
A
K
R
V
SALTPS
T
T
L
A
I
T
A
K
A
K
E
L
K
AAGH
D
V
I
GLGAGEPDFN
T
P
Q
H
I
I
D
A
A
V
R
S
MNEGH
T
K
YTPSG
G
L
A
E
L
K
N
S
I
A
E
K
F
K
RDQNIEYKP-
S
Q
I
I
V
CTGA
K
H
A
L
Y
T
L
F
Q
V
I
LDEED
E
V
I
IPTPYWVSY
P
E
Q
V
KLAGG
K
P
V
Y
V
EGLEENHFKI
S
P
E
Q
L
K
N
A
I
TEKT
K
A
I
V
I
NSPSNPT
G
V
M
Y
T
E
E
E
L
S
A
L
G
E
V
C
L
EH
D
I
L
I
V
S
D
E
I
Y
E
K
L
TYGGKK
H
V
S
I
A
Q
L
S
D
R
LKE
Q
T
V
I
I
NGVSKSHSMT
G
W
R
I
GYAAG
S
E
D
I
I
K
A
M
T
N
L
ASHSTSNP
T
S
I
A
QY
G
A
I
AAYNG--P
S
--
E
--
P
L
E
E
M
-
R
E
A
F
E
H
R
L
N
T
I
Y
A
K
L
I
EIPG
F
S
C
VKPEG
A
F
Y
LFP
N
A
K
E
A
A
Q
SCG
F
K
D
V
D
E
F
V
K
A
-
L
L
EEE
K
V
A
I
VPGSGFGS--PE
N
--
V
R
L
S
YA
T
S
L
D
L
L
E
E
A
I
E
R
I
K
R
F
V
E
KHS
47
HHSearch
98.31
45%
-93
- C1 -
1J32
2
?
A:
[1-387]
M
K
L
A
A
R
V
E
S
V
S
P
S
M
T
L
I
I
D
A
K
A
K
A
M
K
A
E
G
I
D
V
C
S
F
S
A
G
E
P
D
F
N
T
P
K
H
I
V
E
A
A
K
A
A
L
E
Q
G
K
T
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
L
C
Y
G
A
-
D
N
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
E
G
T
P
V
I
L
P
T
T
V
E
T
Q
F
K
V
S
P
E
Q
I
R
Q
A
I
T
P
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
D
D
A
Q
H
L
S
I
G
A
A
S
P
E
A
Y
E
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
G
P
V
P
L
V
K
A
A
T
K
I
Q
G
H
S
T
S
N
V
C
T
F
A
Q
Y
G
A
I
A
A
Y
E
N
--
S
Q
--
D
--
C
V
Q
E
M
-
L
A
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
L
E
C
P
K
P
D
G
A
F
Y
M
F
P
S
I
A
K
T
G
-----
R
S
S
L
D
F
C
S
E
-
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
G
A
--
D
D
C
--
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
H
G
I
-
1
PsiBlast_PDB
97.38
45%
-95
- C1 -
1J32
2
?
A:
[1-384]
M
K
L
A
A
R
V
E
S
V
S
P
S
M
T
L
I
I
D
A
K
A
K
A
M
K
A
E
G
I
D
V
C
S
F
S
A
G
E
P
D
F
N
T
P
K
H
I
V
E
A
A
K
A
A
L
E
Q
G
K
T
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
L
C
Y
G
A
-
D
N
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
E
G
T
P
V
I
L
P
T
T
V
E
T
Q
F
K
V
S
P
E
Q
I
R
Q
A
I
T
P
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
D
D
A
Q
H
L
S
I
G
A
A
S
P
E
A
Y
E
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
G
P
V
P
L
V
K
A
A
T
K
I
Q
G
H
S
T
S
N
V
C
T
F
A
Q
Y
G
A
I
A
A
Y
E
N
--
S
Q
--
D
--
C
V
Q
E
M
-
L
A
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
L
E
C
P
K
P
D
G
A
F
Y
M
F
P
S
I
A
K
T
G
R
S
S
-----
L
D
F
C
S
E
-
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
G
A
--
D
D
C
--
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
----
21
PsiBlast_CBE
95.35
45%
-96
- C1 -
1J32
2
?
B:
[1-384]
M
K
L
A
A
R
V
E
S
V
S
P
S
M
T
L
I
I
D
A
K
A
K
A
M
K
A
E
G
I
D
V
C
S
F
S
A
G
E
P
D
F
N
T
P
K
H
I
V
E
A
A
K
A
A
L
E
Q
G
K
T
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
L
C
Y
G
A
-
D
N
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
E
G
T
P
V
I
L
P
T
T
V
E
T
Q
F
K
V
S
P
E
Q
I
R
Q
A
I
T
P
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
D
D
A
Q
H
L
S
I
G
A
A
S
P
E
A
Y
E
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
G
P
V
P
L
V
K
A
A
T
K
I
Q
G
H
S
T
S
N
V
C
T
F
A
Q
Y
G
A
I
A
A
Y
E
N
--
S
Q
--
D
--
C
V
Q
E
M
-
L
A
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
L
E
C
P
K
P
D
G
A
F
Y
M
F
P
S
I
A
K
T
G
R
S
S
-----
L
D
F
C
S
E
-
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
G
A
--
D
D
C
--
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
----
45
PsiBlast_CBE
86.78
41%
-104
- C1 -
1O4S
4
AAT_THEMA
B:
[14-386]
--
V
S
R
R
I
S
E
I
P
I
S
K
T
M
E
L
D
A
K
A
K
A
L
I
K
K
G
E
D
V
I
N
L
T
A
G
E
P
D
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
G
E
V
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
K
D
I
S
P
-
D
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
G
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
G
G
T
V
N
V
V
E
T
F
M
S
K
N
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
-
T
D
E
F
T
S
I
L
D
V
S
E
G
F
-
D
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
S
S
E
K
V
A
T
A
V
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
A
Q
Y
A
A
L
K
A
L
E
V
--
D
N
-------
S
Y
M
-
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
-
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
F
K
V
R
--------
G
D
D
V
K
F
C
E
R
-
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
L
K
--
P
G
F
--
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
----
13
PsiBlast_PDB
86.43
41%
-101
- C1 -
1O4S
8
AAT_THEMA
A:
[14-386]
--
V
S
R
R
I
S
E
I
P
I
S
K
T
M
E
L
D
A
K
A
K
A
L
I
K
K
G
E
D
V
I
N
L
T
A
G
E
P
D
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
G
E
V
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
K
D
I
S
P
-
D
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
G
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
G
G
T
V
N
V
V
E
T
F
M
S
K
N
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
-
T
D
E
F
T
S
I
L
D
V
S
E
G
F
-
D
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
S
S
E
K
V
A
T
A
V
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
A
Q
Y
A
A
L
K
A
L
E
V
--
D
N
-------
S
Y
M
-
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
-
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
F
K
V
R
--------
G
D
D
V
K
F
C
E
R
-
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
L
K
--
P
G
F
--
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
----
49
HHSearch
86.10
43%
-99
- C1 -
1O4S
8
AAT_THEMA
A:
[15-388]
---
S
R
R
I
S
E
I
P
I
S
K
T
M
E
L
D
A
K
A
K
A
L
I
K
K
G
E
D
V
I
N
L
T
A
G
E
P
D
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
G
E
V
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
K
D
I
S
P
-
D
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
G
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
G
G
T
V
N
V
V
E
T
F
M
S
K
N
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
T
D
E
F
-
T
S
I
L
D
V
S
E
-
G
F
D
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
S
S
E
K
V
A
T
A
V
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
A
Q
Y
A
A
L
K
A
L
E
V
---------
D
N
S
Y
M
-
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
-
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
F
K
V
R
G
D
--------
D
V
K
F
C
E
R
-
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
L
K
--
P
G
F
--
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
N
S
--
52
HHSearch
85.42
46%
-53
- C1 -
1B5P
3
AAT_THET8
A:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
H
F
S
P
G
-
R
V
A
P
---
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
--
Q
E
A
S
R
A
-
F
V
E
M
A
-
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
-----
P
D
E
V
R
A
A
E
R
-
L
L
-
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
36
PsiBlast_CBE
84.77
44%
-61
- C1 -
1GC3
4
AAT_THET8
E:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
D
A
V
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
H
F
S
P
G
R
V
A
---
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
QE
A
S
--
R
--
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
-------
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
8
PsiBlast_PDB
84.53
44%
-59
- C1 -
1GC4
4
AAT_THET8
A:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
D
A
V
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
H
F
S
P
G
R
V
A
---
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
E
A
S
--
R
--
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
-------
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
7
PsiBlast_PDB
84.38
44%
-63
- C1 -
1GC3
4
AAT_THET8
A:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
D
A
V
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
H
F
S
P
G
R
V
A
---
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
E
A
S
--
R
--
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
-------
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
31
PsiBlast_CBE
84.37
44%
-60
- C1 -
1GC4
4
AAT_THET8
C:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
D
A
V
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
H
F
S
P
G
R
V
A
---
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
QE
A
S
--
R
--
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
-------
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
32
PsiBlast_CBE
84.19
44%
-59
- C1 -
1GC4
4
AAT_THET8
B:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
D
A
V
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
H
F
S
P
G
R
V
A
---
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
QE
A
S
--
R
--
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
-------
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
34
PsiBlast_CBE
83.49
44%
-61
- C1 -
1GC3
4
AAT_THET8
G:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
D
A
V
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
H
F
S
P
G
R
V
A
---
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
QE
A
S
--
R
--
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
-------
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
35
PsiBlast_CBE
83.26
44%
-60
- C1 -
1GC3
4
AAT_THET8
F:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
D
A
V
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
H
F
S
P
G
R
V
A
---
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
QE
A
S
--
R
--
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
-------
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
38
PsiBlast_CBE
83.15
44%
-60
- C1 -
1GC3
4
AAT_THET8
C:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
D
A
V
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
H
F
S
P
G
R
V
A
---
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
QE
A
S
--
R
--
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
-------
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
3
PsiBlast_PDB
83.12
45%
-54
- C1 -
1B5O
3
AAT_THET8
A:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
H
F
S
P
G
R
V
A
---
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
E
A
S
--
R
--
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
-------
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
23
PsiBlast_CBE
82.84
45%
-55
- C1 -
1BKG
3
AAT_THET8
C:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
-
E
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
H
F
S
P
G
R
V
A
---
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
QE
A
S
--
R
--
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
-------
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
2
PsiBlast_PDB
82.59
45%
-56
- C1 -
1BKG
4
AAT_THET8
A:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
-
E
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
H
F
S
P
G
R
V
A
---
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
E
A
S
--
R
--
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
-------
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
6
PsiBlast_PDB
82.55
45%
-55
- C1 -
1B5P
3
AAT_THET8
A:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
H
F
S
P
G
R
V
A
---
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
E
A
S
--
R
--
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
-------
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
37
PsiBlast_CBE
82.48
44%
-59
- C1 -
1GC3
4
AAT_THET8
D:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
D
A
V
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
H
F
S
P
G
R
V
A
---
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
QE
A
S
--
R
--
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
-------
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
26
PsiBlast_CBE
81.89
45%
-53
- C1 -
1GCK
4
AAT_THET8
B:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
H
F
S
P
G
R
V
A
---
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
QE
A
S
--
R
--
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
-------
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
5
PsiBlast_PDB
81.59
45%
-56
- C1 -
1GCK
4
AAT_THET8
A:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
H
F
S
P
G
R
V
A
---
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
E
A
S
--
R
--
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
-------
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
27
PsiBlast_CBE
81.20
45%
-54
- C1 -
1B5P
3
AAT_THET8
B:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
H
F
S
P
G
R
V
A
---
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
QE
A
S
--
R
--
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
-------
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
25
PsiBlast_CBE
80.92
45%
-54
- C1 -
1B5O
3
AAT_THET8
B:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
H
F
S
P
G
R
V
A
---
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
QE
A
S
--
R
--
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
-------
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----
12
PsiBlast_PDB
79.65
39%
-20
- C1 -
1GD9
2
?
A:
[2-386]
-
A
L
S
D
R
L
E
L
V
S
A
S
E
I
----
R
K
L
F
D
I
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
I
A
S
L
-
D
G
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
D
--
E
R
S
W
K
--
A
V
E
E
M
-
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
G
L
T
S
-----
K
K
F
S
E
L
-
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
--
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
-
43
PsiBlast_CBE
79.01
39%
-21
- C1 -
1GDE
4
?
B:
[2-386]
-
A
L
S
D
R
L
E
L
V
S
A
S
E
I
----
R
K
L
F
D
I
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
I
A
S
L
-
D
G
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
D
--
E
R
SW
K
--
A
V
E
E
M
-
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
G
L
T
S
-----
K
K
F
S
E
L
-
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
--
A
G
E
GY
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
-
48
HHSearch
78.62
41%
-20
- C1 -
1GD9
2
?
A:
[2-386]
-
A
L
S
D
R
L
E
L
V
S
A
S
E
I
R
K
L
F
D
----
I
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
I
A
S
L
D
G
-
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
D
--
E
R
--
S
W
K
A
V
E
E
M
-
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
G
-----
L
T
S
K
K
F
S
E
L
-
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
AG
E
G
Y
--
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
-
44
PsiBlast_CBE
78.41
39%
-19
- C1 -
1GD9
2
?
B:
[2-386]
-
A
L
S
D
R
L
E
L
V
S
A
S
E
I
----
R
K
L
F
D
I
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
I
A
S
L
-
D
G
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
D
--
E
R
SW
K
--
A
V
E
E
M
-
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
G
L
T
S
-----
K
K
F
S
E
L
-
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
--
A
G
E
GY
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
-
11
PsiBlast_PDB
78.15
39%
-21
- C1 -
1GDE
4
?
A:
[2-386]
-
A
L
S
D
R
L
E
L
V
S
A
S
E
I
----
R
K
L
F
D
I
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
G
G
K
P
V
E
V
P
T
Y
E
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
R
H
Y
S
I
A
S
L
-
D
G
M
F
E
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
D
--
E
R
S
W
K
--
A
V
E
E
M
-
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
G
L
T
S
-----
K
K
F
S
E
L
-
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
--
A
G
E
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
-
29
PsiBlast_CBE
75.49
44%
-55
- C1 -
5BJ4
3
AAT_THET8
B:
[4-382]
--
L
S
R
R
V
Q
A
M
K
P
----------------
G
V
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
-
E
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
G
G
V
V
V
E
V
E
T
L
P
E
E
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
-
E
H
F
S
P
G
R
V
A
---
P
E
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
QE
A
S
--
R
--
A
F
V
E
M
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
-------
D
E
V
R
A
A
E
R
L
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
--
F
G
H
--
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
----