@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22450: (2016-07-04 )
MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIATDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFISSLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLRAVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQTRLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLPGKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAYQNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLKTCGQH
Atome Classification :
(31 SA)
-------------.........10.......----.20........30.......---.40........50........----60---.----..----...------.-------.---.70..-.----.....80........90........100--........110.......120..---------......130.......140.......150.......160.......---170--........180..--.....190.......200.......210.....--..220..-.....230......-.-240--------------.-------------.----------------------------......250....------...260.---------------.....-.270.......280.......-290----..-------.-----------..---...300.......310--.---.......320....-.....330......-------.340..-..-----...350.......360.......370.......380.......390.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------MEK
V
F
I
K
A
L
P
V
L
R
I
L
I
EA----GH
Q
A
Y
F
VG
G
A
V
R
D
S
Y
M
K
R
TI---GDVDIATDAA
P
D
Q
V
E
R
L
F
Q
R
T
----
V
----D----VG----KEH------
G
-------
T
---
I
I
V
L
W-E----DE
T
Y
E
V
T
T
F
RTESDYVDFRRP
S
E
V
Q
F
I
---
S
S
L
E
E
D
L
K
RRD
L
T
I
N
A
M
A
MT-AD---------G
K
V
L
DYFGGK
K
D
I
D
Q
K
V
I
R
TVGKP
E
D
R
F
Q
E
D
A
L
R
M
L
R
A
V
R
F
M
S
QLG---FT---LSP
E
T
E
E
A
I
A
K
E
K
--
S
L
L
S
H
V
SVE
R
K
T
I
E
F
E
K
L
L
Q
G
R
A
S
R
Q
A
L
Q
T
L
I
Q
--
T
R
L
Y
E
E
L
-
P
G
F
Y
H
K
R
E
NLISTS-E-F-P--------------
F
-------------
F
----------------------------SLT
S
R
E
E
L
W
A
A
L
L
------
I
NL
G
I
V
L---------------KDA
P
L
-
F
L
K
A
WKL
P
G
K
V
I
K
E
A
I
H
I
A
D
T
-FG-----Q
S
-------
L
-----------
D
A
---
M
T
M
Y
R
A
G
K
K
A
L
L
S
A
A
---
K
---
I
S
Q
L
R
QNE--KL
D
E
-
K
K
L
K
D
I
Q
Y
A
Y
QNLP-------IKSLKD-LD-----IT
G
K
D
L
L
A
L
RNRPAGK
W
V
S
E
E
L
Q
W
I
E
Q
A
V
V
TGKLSN
Q
K
K
H
I
E
E
W
L
K
T
CGQH
21
PsiBlast_CBE
94.46
44%
-72
- C4 -
1MIY
3
CCA_GEOSE
B:
[1-393]
-------------
M
K
P
P
F
Q
E
A
L
G
I
I
Q
Q
L
K
Q
H
----
G
Y
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
I
---
G
D
V
D
I
A
T
S
A
L
P
E
D
V
M
A
I
F
P
K
T
----
I
----
D
----
V
G
----
S
K
H
------
G
-------
T
---
V
V
V
V
H
-
K
----
G
K
A
Y
E
V
T
T
F
K
T
D
G
---------
S
V
T
F
V
---
R
S
L
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
M
D
-
E
Y
---------
G
T
I
I
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
T
V
G
E
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
G
---
F
A
---
L
A
P
D
T
E
Q
A
I
V
Q
N
A
--
P
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
G
P
F
A
A
R
A
L
P
L
L
A
E
--
T
G
L
N
A
Y
L
-
P
G
L
A
G
K
E
K
Q
L
R
L
A
A
-
A
-
Y
-
R
--------------
W
-------------
P
----------------------------
W
L
A
A
R
E
E
R
W
A
L
L
C
------
H
A
L
G
V
-----------------
Q
E
S
R
P
-
F
L
R
A
W
K
L
P
N
K
V
V
D
E
A
G
A
I
L
T
A
-
L
A
DIPRP
E
A
-------
W
-----------
T
N
---
E
Q
L
F
S
A
G
L
E
R
A
L
S
V
E
---
T
---
V
R
A
A
F
T
G
A
--
P
P
G
P
-
W
H
E
K
-
L
R
R
R
F
A
S
L
P
-------
I
K
T
K
G
E
-
L
A
-----
V
N
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
I
Y
A
W
L
------
1
PsiBlast_PDB
94.28
44%
-74
- C4 -
1MIY
3
CCA_GEOSE
A:
[1-393]
-------------
M
K
P
P
F
Q
E
A
L
G
I
I
Q
Q
L
K
Q
H
----
G
Y
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
I
---
G
D
V
D
I
A
T
S
A
L
P
E
D
V
M
A
I
F
P
K
T
----
I
----
D
----
V
G
----
S
K
H
------
G
-------
T
---
V
V
V
V
H
-
K
----
G
K
A
Y
E
V
T
T
F
K
T
D
G
---------
S
V
T
F
V
---
R
S
L
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
M
D
-
E
Y
---------
G
T
I
I
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
T
V
G
E
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
G
---
F
A
---
L
A
P
D
T
E
Q
A
I
V
Q
N
A
--
P
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
G
P
F
A
A
R
A
L
P
L
L
A
E
--
T
G
L
N
A
Y
L
-
P
G
L
A
G
K
E
K
Q
L
R
L
A
A
-
A
-
Y
-
R
--------------
W
-------------
P
----------------------------
W
L
A
A
R
E
E
R
W
A
L
L
C
------
H
A
L
G
V
-----------------
Q
E
S
R
P
-
F
L
R
A
W
K
L
P
N
K
V
V
D
E
A
G
A
I
L
T
A
-
L
A
D
I
PRP
E
A
-------
W
-----------
T
N
---
E
Q
L
F
S
A
G
L
E
R
A
L
S
V
E
---
T
---
V
R
A
A
F
T
G
A
--
P
P
G
P
-
W
H
E
K
-
L
R
R
R
F
A
S
L
P
-------
I
K
T
K
G
E
-
L
A
-----
V
N
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
I
Y
A
W
L
------
2
PsiBlast_PDB
93.49
44%
-78
- C4 -
1MIV
1
CCA_GEOSE
A:
[5-393]
-----------------
F
Q
E
A
L
G
I
I
Q
Q
L
K
Q
H
----
G
Y
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
I
---
G
D
V
D
I
A
T
S
A
L
P
E
D
V
M
A
I
F
P
K
T
----
I
----
D
----
V
G
----
S
K
H
------
G
-------
T
---
V
V
V
V
H
-
K
----
G
K
A
Y
E
V
T
T
F
K
T
D
G
---------
S
V
T
F
V
---
R
S
L
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
M
D
-
E
Y
---------
G
T
I
I
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
T
V
G
E
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
G
---
F
A
---
L
A
P
D
T
E
Q
A
I
V
Q
N
A
--
P
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
G
P
F
A
A
R
A
L
P
L
L
A
E
--
T
G
L
N
A
Y
L
-
P
G
L
A
G
K
E
K
Q
L
R
L
A
A
-
A
-
Y
-
R
--------------
W
-------------
P
----------------------------
W
L
A
A
R
E
E
R
W
A
L
L
C
------
H
A
L
G
V
-----------------
Q
E
S
R
P
-
F
L
R
A
W
K
L
P
N
K
V
V
D
E
A
G
A
I
L
T
A
-
L
A
D
I
PRP
E
A
-------
W
-----------
T
N
---
E
Q
L
F
S
A
G
L
E
R
A
L
S
V
E
---
T
---
V
R
A
A
F
T
G
A
--
P
P
G
P
-
W
H
E
K
-
L
R
R
R
F
A
S
L
P
-------
I
K
T
K
G
E
-
L
A
-----
V
N
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
I
Y
A
W
L
------
3
PsiBlast_PDB
93.46
44%
-74
- C4 -
1MIW
2
CCA_GEOSE
A:
[5-393]
-----------------
F
Q
E
A
L
G
I
I
Q
Q
L
K
Q
H
----
G
Y
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
I
---
G
D
V
D
I
A
T
S
A
L
P
E
D
V
M
A
I
F
P
K
T
----
I
----
D
----
V
G
----
S
K
H
------
G
-------
T
---
V
V
V
V
H
-
K
----
G
K
A
Y
E
V
T
T
F
K
T
D
G
---------
S
V
T
F
V
---
R
S
L
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
M
D
-
E
Y
---------
G
T
I
I
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
T
V
G
E
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
G
---
F
A
---
L
A
P
D
T
E
Q
A
I
V
Q
N
A
--
P
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
G
P
F
A
A
R
A
L
P
L
L
A
E
--
T
G
L
N
A
Y
L
-
P
G
L
A
G
K
E
K
Q
L
R
L
A
A
-
A
-
Y
-
R
--------------
W
-------------
P
----------------------------
W
L
A
A
R
E
E
R
W
A
L
L
C
------
H
A
L
G
V
-----------------
Q
E
S
R
P
-
F
L
R
A
W
K
L
P
N
K
V
V
D
E
A
G
A
I
L
T
A
-
L
A
D
I
PRP
E
A
-------
W
-----------
T
N
---
E
Q
L
F
S
A
G
L
E
R
A
L
S
V
E
---
T
---
V
R
A
A
F
T
G
A
--
P
P
G
P
-
W
H
E
K
-
L
R
R
R
F
A
S
L
P
-------
I
K
T
K
G
E
-
L
A
-----
V
N
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
I
Y
A
W
L
------
30
HHSearch
91.73
43%
-71
- C4 -
1MIW
2
CCA_GEOSE
A:
[1-398]
-------------
M
K
P
P
F
Q
E
A
L
G
I
I
Q
Q
L
K
Q
H
----
G
Y
D
A
Y
F
V
G
G
A
V
R
D
L
L
L
G
R
P
I
---
G
D
V
D
I
A
T
S
A
L
P
E
D
V
M
A
I
F
P
K
T
----
I
----
D
----
V
G
----
S
K
H
------
G
-------
T
---
V
V
V
V
H
-
K
----
G
K
A
Y
E
V
T
T
F
K
T
D
G
---------
S
V
T
F
V
---
R
S
L
E
E
D
L
K
R
R
D
F
T
M
N
A
I
A
M
D
-
E
Y
---------
G
T
I
I
D
P
F
G
G
R
E
A
I
R
R
R
I
I
R
T
V
G
E
A
E
K
R
F
R
E
D
A
L
R
M
M
R
A
V
R
F
V
S
E
L
G
---
F
A
---
L
A
P
D
T
E
Q
A
I
V
Q
N
A
--
P
L
L
A
H
I
S
V
E
R
M
T
M
E
M
E
K
L
L
G
G
P
F
A
A
R
A
L
P
L
L
A
E
--
T
G
L
N
A
-
Y
-
L
P
G
L
A
G
K
E
K
Q
L
R
L
A
A
A
-
Y
-
R
W-------------
P
-------------
W
----------------------------
L
A
A
R
E
E
-
R
W
A
L
L
C
H
-----
A
L
G
V
Q
------------------
E
S
R
P
-
F
L
R
A
W
K
L
P
N
K
V
V
D
E
A
G
A
I
L
T
A
L
A
D
-----
I
P
RPEA---
W
-----------
T
N
---
E
Q
L
F
S
A
G
L
E
R
A
L
S
V
E
---
T
---
V
R
A
A
F
T
G
A
---
P
P
G
-
P
W
H
E
K
L
R
R
R
F
A
S
L
P
-------
I
K
T
K
G
E
-
L
A
-----
V
N
G
K
D
V
I
E
W
V
G
K
P
A
G
P
W
V
K
E
A
L
D
A
I
W
R
A
V
V
N
G
E
V
E
N
E
K
E
R
I
Y
A
W
L
M
E
R
N
R
-
35
HHSearch
68.35
31%
-61
- C4 -
3AQL
2
?
A:
[15-349]
--------------
K
D
I
S
E
N
A
L
K
V
M
Y
R
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
C
----
R
----
L
----
V
G
----
R
R
F
------
R
-------
L
---
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G
-------------
N
I
F
---
G
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
S
-
V
A
D--------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
---
M
R
---
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
--
Y
H
L
F
Q
P
L
-
F
P
T
I
T
R
Y
F
T
E
N
G
D
S
-
P
M
E
R
I
I
E
Q
V
L
K
N
T
D
T
R
I
H
N
D
-------------
M
----------------------------
R
V
N
P
A
F
-
L
F
A
A
M
F
W
Y
P
L
L
E
T
A
Q
K
I
A
Q
E
S
GLT
Y
H
D
A
F
A
L
A
M
N
D
V
L
D
E
-
A
C
R
S
L
A
I
P
K
R
L
T
T
L
T
R
D
I
W
Q
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
65.50
29%
37
- C4 -
3AQL
2
?
A:
[1-411]
QVTVIPREQHAIS
R
K
D
I
S
E
N
A
L
K
V
M
Y
R
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
C
----
R
----
L
----
V
G
----
R
R
F
------
R
-------
L
---
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G
N
I
F
----------------
G
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
S
V
A
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
---
M
R
---
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
--
Y
H
L
F
Q
P
L
-
F
P
T
I
T
R
Y
F
T
E
N
G
D
S
-
P
-
M
-
E
--------------
R
-------------
I
----------------------------
I
E
Q
V
L
K
N
T
D
T
R
I
H
------
N
D
M
R
V
-------------------
N
P
A
-
F
L
F
A
A
M
F
W
Y
P
L
L
E
T
A
Q
K
I
A
Q
E
-
S
G
-----
L
T
-------------------
Y
H
---
D
A
F
A
L
A
M
N
D
V
L
D
E
A
C
---
R
---
S
L
A
I
P
K
R
L
--
T
T
L
T
-
R
D
I
W
Q
L
Q
L
R
M
S
R
R
Q
-------
G
K
R
A
W
K
-
L
L
E
HPK
F
R
A
A
Y
D
L
L
A
L
R
A
E
V
E
R
N
A
E
L
Q
R
L
V
K
W
W
G
E
F
Q
V
S
A
P
P
D
Q
K
G
M
L
----------
6
PsiBlast_PDB
64.03
38%
-49
- C4 -
3AQN
2
?
A:
[20-248]
-------------------
N
A
L
K
V
M
Y
R
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
C
----
R
----
L
----
V
G
----
R
R
F
------
R
-------
L
---
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G
----------------NIF
G
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
S
V
A
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
---
M
R
---
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
--
Y
H
L
F
Q
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
63.98
38%
-40
- C4 -
3AQL
2
?
B:
[20-248]
-------------------
N
A
L
K
V
M
Y
R
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
C
----
R
----
L
----
V
G
----
R
R
F
------
R
-------
L
---
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G
----------------NIF
G
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
S
V
A
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
---
M
R
---
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
--
Y
H
L
F
Q
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
63.85
23%
18
- C4 -
3H38
-
?
A:
[14-424]
---------------
R
V
D
P
K
I
L
N
L
F
R
L
L
G
K
F
G
D
E
V
N
M
P
V
Y
V
V
G
G
F
V
R
D
L
L
L
G
I
K
N
---
L
D
I
D
I
V
V
E
G
N
A
L
E
F
A
E
Y
A
K
R
F
----
L
P
G
K
L
V
----
K
H
----
D
K
F
------
M
-------
T
---
A
S
L
F
L
K
G
----
G
L
R
I
D
I
A
T
A
R
L
E
Y
Y
E
S
P
A
K
L
P
D
-
V
E
-
M
---
S
T
I
K
K
D
L
Y
R
R
D
F
T
I
N
A
M
A
I
K
-
L
N
PKDF-----
G
L
L
I
D
F
F
G
G
Y
R
D
L
K
E
G
V
I
R
V
L
H
T
--
L
S
F
V
D
D
P
T
R
I
L
R
A
I
R
F
E
Q
R
F
D
---
F
R
---
I
E
E
T
T
E
R
L
L
K
Q
A
V
E
E
G
Y
L
E
R
T
T
G
P
R
L
R
Q
E
L
E
K
I
L
E
E
K
N
P
L
K
S
I
R
R
M
A
Q
--
F
D
V
I
K
H
L
-
F
P
K
T
Y
Y
T
P
S
M
D
E
K
M
-
E
-
N
-
L
F
-------------
R
N
I
P
W
V
E
-------
E
----------------------------
N
F
G
E
V
D
-
R
F
Y
A
V
L
H
-----
V
F
L
E
F
Y
D
D
--------------
E
S
W
K
E
-
V
R
D
R
Y
S
L
R
R
N
L
I
N
E
I
R
H
V
E
K
S
A
P
------
A
L
L
E
M
L
S
E
R
V
-----------
P
A
---
S
F
V
Y
P
L
V
K
G
V
S
N
E
T
I
---
C
H
F
-
L
A
Y
L
S
G
---------
E
K
E
G
L
F
K
S
Y
---
L
L
-------
K
I
K
N
T
K
L
E
K
-----
I
N
G
E
Y
L
I
R
-
K
G
I
T
S
G
K
I
I
G
E
V
L
E
K
I
L
M
K
K
L
D
G
D
T
R
D
E
E
E
I
L
-
E
E
V
L
A
S
L
--
5
PsiBlast_PDB
63.75
38%
-46
- C4 -
3AQL
2
?
A:
[20-248]
-------------------
N
A
L
K
V
M
Y
R
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
C
----
R
----
L
----
V
G
----
R
R
F
------
R
-------
L
---
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G
----------------NIF
G
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
S
V
A
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
---
M
R
---
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
--
Y
H
L
F
Q
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
63.61
26%
11
- C4 -
4X4W
11
TRNT1_HUMAN
A:
[16-409]
-----------------
T
E
G
L
K
S
L
T
E
L
F
V
K
E
----
N
H
E
L
R
I
A
G
G
A
V
R
D
L
L
N
G
V
K
P
---
Q
D
I
D
F
A
T
T
A
T
P
T
Q
M
K
E
M
F
Q
S
A
----
G
----
I
R
M
I
N---------------
G
-------
T
---
I
T
A
R
L
-
H
----
E
E
N
F
E
I
T
T
L
R
I
D
V
T
-
T
D
G
--
A
-
E
V
E
F
T
---
T
D
W
Q
K
D
A
E
R
R
D
L
T
I
N
S
M
F
L
G
-
F
D
---------
G
T
L
F
D
Y
F
N
G
Y
E
D
L
K
N
K
K
V
R
F
V
G
H
A
K
Q
R
I
Q
E
D
Y
L
R
I
L
R
Y
F
R
F
Y
G
R
I
V
DKP
G
D
---
H
D
P
E
T
L
E
A
I
A
E
N
A
--
K
G
L
A
G
I
S
G
E
R
I
W
V
E
L
K
K
I
L
V
G
N
H
V
N
H
L
I
H
L
I
Y
D
--
L
D
V
A
P
Y
I
G
L
P
A
N
A
S
L
E
E
F
D
K
V
S
K
N
-
V
-
D
--------------
G
-------------
F
----------------------------
S
P
K
P
V
T
-
L
L
A
S
L
F
K-----
V
Q
D
D
--------------------
V
T
K
-
L
D
L
R
L
K
I
A
K
E
E
K
N
L
G
L
F
I
V
K
N
R
K
------
D
L
-------
I
-----------
K
A
T
DS
S
D
P
L
K
P
Y
Q
D
F
---
I
I
---
D
---
S
---
D
A
T
T
R
V
C
E
L
L
-
K
Y
-
Q
G
E
H
C
L
L
K
E
M
Q
-------
Q
W
S
I
P
P
-
F
P
-----
V
S
G
H
D
I
R
K
-
V
G
I
S
S
G
K
E
I
G
A
L
L
Q
Q
L
R
E
Q
W
K
K
S
G
Y
Q
M
E
K
D
E
L
L
S
Y
I
K
K
T
L
--
4
PsiBlast_PDB
63.37
38%
-43
- C4 -
3AQM
1
?
A:
[20-248]
-------------------
N
A
L
K
V
M
Y
R
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
C
----
R
----
L
----
V
G
----
R
R
F
------
R
-------
L
---
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G
----------------NIF
G
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
S
V
A
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
---
M
R
---
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
L
L
N
D
I
P
P
A
R
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
--
Y
H
L
F
Q
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
63.05
38%
-39
- C4 -
3AQN
1
?
B:
[20-248]
-------------------
N
A
L
K
V
M
Y
R
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
C
----
R
----
L
----
V
G
----
R
R
F
------
R
-------
L
---
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G
----------------NIF
G
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
S
V
A
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
---
M
R
---
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
--
Y
H
L
F
Q
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
62.61
38%
-40
- C4 -
3AQM
1
?
B:
[20-248]
-------------------
N
A
L
K
V
M
Y
R
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
C
----
R
----
L
----
V
G
----
R
R
F
------
R
-------
L
---
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
G
----------------NIF
G
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
S
V
A
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
---
M
R
---
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
L
L
N
D
I
P
P
A
R
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
--
Y
H
L
F
Q
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
60.95
38%
-47
- C4 -
3AQK
-
?
A:
[36-264]
-------------------
N
A
L
K
V
M
Y
R
L
N
K
A
----
G
Y
E
A
W
L
V
G
G
G
V
R
D
L
L
L
G
K
K
P
---
K
D
F
D
V
T
T
N
A
T
P
E
Q
V
R
K
L
F
R
N
C
----
R
----
L
----
V
G
----
R
R
F
------
R
-------
L
---
A
H
V
M
F
-
G
----
P
E
I
I
E
V
A
T
F
R
-----------------NIF
G
S
I
E
E
D
A
Q
R
R
D
F
T
I
N
S
L
Y
Y
S
V
A
D
---------
F
T
V
R
D
Y
V
G
G
M
K
D
L
K
D
G
V
I
R
L
I
G
N
P
E
T
R
Y
R
E
D
P
V
R
M
L
R
A
V
R
F
A
A
K
L
G
---
M
R
---
I
S
P
E
T
A
E
P
I
P
R
L
A
--
T
L
L
N
D
I
P
P
A
H
L
F
E
E
S
L
K
L
L
Q
A
G
Y
G
Y
E
T
Y
K
L
L
C
E
--
Y
H
L
F
Q
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
59.34
21%
13
- C4 -
3WFP
1
?
A:
[7-356]
------------------
S
Y
F
D
D
V
A
K
V
L
-
P
R
----
E
H
Y
C
F
I
V
G
G
W
V
R
D
R
I
L
G
E
P
V
GY
N
I
D
V
D
F
L
T
T
A
D
P
V
E
L
A
K
N
F
A
K
R
--------------
I
G
----
G
H
F
F
V
F
E
K
R
G
FLIK
R
P
T
I
---
A
S
V
V
L
-
H
L
PP
Y
R
Y
R
F
D
F
S
P
L
K
G
K
------------
D
L
E
---
K
A
L
I
E
D
L
K
E
R
D
F
T
A
N
A
I
A
V
N
-
L
D
D
V
L
SIGAKQ
T
I
V
Y
D
P
T
G
G
I
K
D
L
E
Q
G
L
L
R
P
V
S
I
--
E
N
L
K
R
D
P
V
R
V
L
R
G
F
R
I
A
I
E
K
N
---
L
Q
---
L
T
E
D
F
Y
E
F
V
K
E
D
P
--
R
I
V
L
K
S
A
V
E
R
I
T
H
E
L
F
K
I
M
K
E
K
T
A
H
K
V
I
R
E
L
Y
E
--
Y
G
V
L
E
A
I
-
I
P
E
I
G
R
L
R
E
V
K
D
-----------------------P
L
D
E
H
T
L
K
T
L
E
Y
-
L
E
Q
V
I
E
D
RAKYLS
A
E
L
L
E
N
FGKKRVLGEF
T
D
V
E
L
L
-
K
W
G
A
L
F
H
-----
D
I
G
K
P
Q
T
FVTFYE
H
D
K
V
G
A
---
Q
I
V
R
E
-
I
G
E
R
L
R
W
G
D
E
A
T
E
F
V
A
K
L
V
R
H
H
L
------
R
P
-------
F
F
L
R
E
A
F
K
K
GEL
K
R
---
R
G
M
A
N
F
W
R
E
C
G
D
I
A
P
H
L
F
L
---
L
S
I
A
D
A
M
A
--
S
------------------------------------------------------------------------------------------
55
Fugue
58.67
26%
42
- C4 -
4X4W
12
TRNT1_HUMAN
A:
[1-409]
---M
F
T
M
K
L
Q
S
P
E
F
Q
S
L
F
T
E
G
L
K
S
L
T
E
L
F
V
K
E
---
N
H
E
L
R
I
A
G
G
A
V
R
D
L
L
N
G
V
K
P
---
Q
D
I
D
F
A
T
T
A
T
P
T
Q
M
K
E
M
F
Q
S
A
---------
G
----
I
R
----
M
I
N
------
G
-------
T
---
I
T
A
R
L
-
H
----
E
E
N
F
E
I
T
T
L
R
I
D
V
T
----
T
D
G
A
E
V
E
F
T
---
T
D
W
Q
K
D
A
E
R
R
D
L
T
I
N
S
M
F
L
G
-
F
D
---------
G
T
L
F
D
Y
F
N
G
Y
E
D
L
K
N
K
K
V
R
F
V
G
H
A
K
Q
R
I
Q
E
D
Y
L
R
I
L
R
Y
F
R
F
Y
G
R
I
V
---
D
K
PGD
H
D
P
E
T
L
E
A
I
A
E
N
A
--
K
G
L
A
G
I
S
G
E
R
I
W
V
E
L
K
K
I
L
V
G
N
H
V
N
H
L
I
H
L
I
Y
D
L
D
V
A
P
Y
I
G
L
-
P
A
N
A
S
L
E
E
F
D
K
V
S
K
-
N
-
V
-
D
--------------
G
-------------
F
----------------------------
S
P
K
P
V
T
L
L
A
S
L
F
K
------
V
Q
D
D
V
T
K
---------------
L
D
L
R
L
K
I
A
K
E
E
K
N
L
G
L
F
I
V
K
N
R
K
D
L
I
K
-
A
T
-----
D
S
-------
S
-----------
D
P
---
L
--------
K
P
Y
Q
D
F
---
I
---
I
D
S
D
A
T
T
R
--
V
C
E
L
-
L
K
Y
Q
G
E
H
C
L
L
K
E
M
Q
-------
Q
W
S
I
P
P
-
F
P
-----
V
S
G
H
D
I
R
K
V
G
I
S
S
G
K
E
I
G
A
L
L
Q
Q
L
R
E
Q
W
K
K
S
G
Y
Q
M
E
K
D
E
L
L
S
Y
I
K
K
T
L
---
34
HHSearch
57.19
20%
21
* C4 *
3WFO
4
?
A:
[24-448]
--------------------
F
D
D
V
A
K
V
L
-
P
R
----
E
H
Y
C
F
I
V
G
G
W
V
R
D
R
I
L
G
E
P
V
GY
N
I
D
V
D
F
L
T
T
A
D
P
V
E
L
A
K
N
F
A
K
R
----
I
G---
G
H
F
F
-
V
F
----
E
-----------------P
T
I
A
S
V
V
L
-
H
L
PP
Y
R
Y
R
F
D
F
S
P
L
K
G
K
------------
D
L
E
---
K
A
L
I
E
D
L
K
E
R
D
F
T
A
N
A
I
A
V
N
-
L
D
D
V
L
SIGA
K
Q
T
I
V
Y
D
P
T
G
G
I
K
D
L
E
Q
G
L
L
R
P
V
S
--
I
E
N
L
K
R
D
P
V
R
V
L
R
G
F
R
I
A
I
E
K
N
---
L
Q
---
L
T
E
D
F
Y
E
F
V
K
E
D
P
--
R
I
V
L
K
S
A
V
E
R
I
T
H
E
L
F
K
I
M
K
E
K
T
A
H
K
V
I
R
E
L
Y
E
--
Y
G
V
L
E
A
I
-
I
P
E
I
G
R
L
R
E
V
K
D
--------P
L
D
E
H
T
L
K
T
L
E
---
Y
-------------
L
E
Q
V
I
E
D
RAKYLS
A
E
L
L
E
N
FGKKRVLGEF
T
D
V
E
L
L
-
K
W
G
A
L
F
H
-----
D
I
G
K
P
Q
T
FVTFYE
H
D
K
V
G
A
---
Q
I
V
R
E
-
I
G
E
R
L
R
W
G
D
E
A
T
E
F
V
A
K
L
V
R
H
H
L
------
R
P
-------
F
F
L
R
E
A
F
K
K
GEL
K
R
---
R
G
M
A
N
F
W
R
E
C
G
D
I
A
P
---
H
L
F
L
L
S
I
A
D
A
M
A
--
S
G
D
E
E
E
D
I
K
A
L
M
E
T
I
A
E
L
E
S
F
N
R
NEM
K
----------------------------------------------------------------
33
HHSearch
57.14
26%
12
- C4 -
4WBY
5
?
A:
[12-396]
-------------------
I
A
R
E
V
G
Q
I
A
K
E
M
----
G
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
V
---
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
R
H
G
V
N
V
----
H
----
P
F
----
P
E
F
------
G
-------
T
---
A
H
L
K
I
-
G
----
K
L
K
L
E
F
A
T
A
R
R
E
--------------
P
---
A
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
--
V
S
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
N
L
G
L
L
K
E
A
P
R
G
R
L
I
N
E
I
K
L
A
L
R
E
D
R
F
L
E
I
L
E
L
Y
R
K
--
Y
R
V
L
E
E
I
-
I
E
G
F
Q
W
N
E
K
V
L
Q
K
L
-
Y
-
A
-
L
--------------
R
K
V
V
D
W
H
A
L
E
F
S
EE
R
----------------------------
I
D
Y
G
W
L
-
Y
L
L
I
L
I
S-----
N
L
D
Y
E
------------------
R
G
K
H
-
F
L
E
E
M
S
A
P
S
W
V
R
E
T
Y
K
F
M
K
F
K
L
G
------
S
L
K
E
E
L
K
K
A
K
-----------
E
N
---
Y
E
V
Y
R
L
L
K
P
L
H
T
S
V
L
---
L
---
L
-
L
M
L
E
-------
E
-
E
L
K
E
K
I
K
L
---
Y
L
E
-------
K
L
R
K
V
K
------------------
G
L
K
-
G
K
E
L
G
E
R
I
E
E
L
K
R
E
I
M
N
K
-------------------
13
PsiBlast_PDB
48.78
36%
2
- C4 -
4WC1
1
?
A:
[8-187]
-----------------------------
E
M
----
G
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
V
---
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
R
----
H
----
G
----
V
N
V
H
P
F
P
E
F
------
G
-------
T
---
A
H
L
K
I
-
G
----
K
L
K
L
E
F
A
T
A
R
R
E
---------------P--
A
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
48.73
36%
10
- C4 -
1VFG
1
?
A:
[8-181]
-----------------------------
E
M
----
G
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
V
---
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
R
----
H
----
G
----
V
N
V
H
P
F
P
E
F
------
G
-------
T
---
A
H
L
K
I
-
G
----
K
L
K
L
E
F
A
T
A
R
R
E
T
-------------
V
EP-
A
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
48.22
36%
11
- C4 -
1VFG
1
?
B:
[8-204]
-----------------------------
E
M
----
G
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
V
---
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
R
----
H
----
G
----
V
N
VHPF
P
E
F
------
G
-------
T
---
A
H
L
K
I
-
G
----
K
L
K
L
E
F
A
T
A
R
R
E
T
-------------
V
EP-
A
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
48.10
36%
3
- C4 -
4WC1
1
?
B:
[8-201]
-----------------------------
E
M
----
G
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
V
---
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
R
----
H
----
G
----
V
N
VHPF
P
E
F
------
G
-------
T
---
A
H
L
K
I
-
G
----
K
L
K
L
E
F
A
T
A
R
R
E
---------------P--
A
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
47.98
36%
10
- C4 -
4WC0
1
?
B:
[8-201]
-----------------------------
E
M
----
G
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
V
---
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
R
----
H
----
G
----
V
N
VHPF
P
E
F
------
G
-------
T
---
A
H
L
K
I
-
G
----
K
L
K
L
E
F
A
T
A
R
R
E
---------------P--
A
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
47.77
36%
13
- C4 -
4WC6
1
?
A:
[8-185]
-----------------------------
E
M
----
G
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
V
---
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
R
----
H
----
G
----
V
N
V
H
P
F
P
E
F
------
G
-------
T
---
A
H
L
K
I
-
G
----
K
L
K
L
E
F
A
T
A
R
R
E
T
--------------EP-
A
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
47.74
36%
17
- C4 -
4WC5
1
?
A:
[8-185]
-----------------------------
E
M
----
G
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
V
---
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
R
----
H
----
G
----
V
N
V
H
P
F
P
E
F
------
G
-------
T
---
A
H
L
K
I
-
G
----
K
L
K
L
E
F
A
T
A
R
R
E
T
--------------EP-
A
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
47.55
36%
19
- C4 -
4WC7
1
?
A:
[8-185]
-----------------------------
E
M
----
G
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
V
---
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
R
----
H
----
G
----
V
N
V
H
P
F
P
E
F
------
G
-------
T
---
A
H
L
K
I
-
G
----
K
L
K
L
E
F
A
T
A
R
R
E
T
--------------EP-
A
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
47.47
36%
14
- C4 -
4WC4
1
?
A:
[8-185]
-----------------------------
E
M
----
G
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
V
---
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
R
----
H
----
G
----
V
N
V
H
P
F
P
E
F
------
G
-------
T
---
A
H
L
K
I
-
G
----
K
L
K
L
E
F
A
T
A
R
R
E
T
--------------EP-
A
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
46.95
36%
10
- C4 -
4WC0
1
?
A:
[8-187]
-----------------------------
E
M
----
G
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
V
---
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
R
----
H
----
G
----
V
N
V
H
P
F
P
E
F
------
G
-------
T
---
A
H
L
K
I
-
G
----
K
L
K
L
E
F
A
T
A
R
R
E
---------------P--
A
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
46.61
36%
22
- C4 -
4WC2
1
?
A:
[8-185]
-----------------------------
E
M
----
G
L
R
A
Y
I
V
G
G
V
V
R
D
I
L
L
G
K
E
V
---
W
D
V
D
F
V
V
E
G
N
A
I
E
L
A
K
E
L
A
R
R
----
H
----
G
----
V
N
V
H
P
F
P
E
F
------
G
-------
T
---
A
H
L
K
I
-
G
----
K
L
K
L
E
F
A
T
A
R
R
E
T
--------------EP-
A
S
L
K
E
D
L
I
R
R
D
F
T
I
N
A
M
A
I
S
-
V
N
LEDY-----
G
T
L
I
D
Y
F
G
G
L
R
D
L
K
D
K
V
I
R
V
L
H
P
V
S
--
F
I
E
D
P
V
R
I
L
R
A
L
R
F
A
G
R
L
N
---
F
K
---
L
S
R
S
T
E
K
L
L
K
Q
A
V
--
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------