@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22600: (2016-07-05 )
MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPGADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILAGRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVSPVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQKLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEIKPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAAELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLGIASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS
Atome Classification :
(28 SA)
....-.....10........20........30........40........50........60.--.-......70........80........90........100.......110.......120.......130.......140.......150-.-...-....160.......170.......180.......190.......200.......-----210---.........220.......230.......240.......250.......260.......270..---.....280.......290..-.-....300.......310.......320.......330.......340.......350.......360.......370----..-------...-----.-...380.......390....-...400........410.......420......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKRD-K
V
Q
TLH
G
E
I
H
IPGDKSISH
R
S
V
M
F
G
ALAA
G
T
T
T
V
K
NFLP
G
A
D
C
L
S
T
I
D
C
F
R
K
MG
V
H
I
E--Q-SSS
D
V
V
I
HGKGIDALKE
P
E
S
L
L
DVGNSG
T
T
I
R
L
M
L
G
I
LAGRP
F
Y
S
AVAG
D
E
S
I
A
K
R
P
M
K
R
V
T
E
P
L
K
K
MGAKIDGRAGGEFT
P
L
SVSG-A-S-LKG-
I
D
YVS
P
V
A
S
A
Q
I
K
S
A
V
L
LAGLQAEG
T
T
TVTEPHKS
R
D
H
T
E
R
M
L
S
A
FGVKLSEDQ-----
T
-----
S
V
S
IAGG
Q
K
L
T
A
A
D
I
F
VPGDI
S
S
A
A
F
F
L
AAGAMVPN
S
R
I
V
L
K
NVGLNPT
R
T
G
I
I
D
V
L
Q
NMG
A
K
L
---
E
I
KPSADSGAEPY
G
D
L
I
I
ET-S-
S
L
K
A
V
EIG
G
D
I
I
P
R
L
I
D
EI
P
I
I
A
L
L
ATQAEG
T
T
V
IKDA
A
E
L
K
VKETN
R
I
D
T
V
V
S
E
L
R
K
LGAEIEPTAD
G
M
K
V
YGK------QT-------LKG-----G-AAVSSHGDH
R
I
G
M
M
L
G
I
A
S
C
-ITEE-P
I
E
I
EHT
D
A
I
H
VS
Y
P
T
F
F
E
H
L
N
K
LSKKS
23
PsiBlast_CBE
95.73
68%
-112
- C7 -
3RMT
8
AROA1_BACHD
B:
[15-434]
---------
L
K
G
T
I
K
V
P
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
E
--
Q
-
A
E
E
R
V
T
V
K
G
K
G
W
D
G
L
R
E
P
S
D
I
L
D
V
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
P
L
S
I
R
G
-
G
-
Q
-
L
K
G
-
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
N
I
E
K
D
G
-----
L
-----
T
V
S
I
E
G
G
Q
M
L
T
G
Q
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
L
E
V
L
K
Q
M
G
A
T
L
---
A
M
E
N
E
R
V
Q
G
G
E
P
V
A
D
L
T
I
E
T
-
S
-
V
L
Q
G
V
E
I
G
G
D
I
I
P
R
L
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
A
E
E
-----
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
P
------
T
P
-------
L
K
G
-----
G
-
V
T
V
S
S
H
G
D
H
R
I
G
M
A
M
A
I
A
A
L
-
L
A
E
K
-
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
F
D
H
L
D
R
L
K
S
E
A
1
PsiBlast_PDB
95.06
68%
-112
- C7 -
3RMT
9
AROA1_BACHD
A:
[15-434]
---------
L
K
G
T
I
K
V
P
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
E
--
Q
-
A
E
E
R
V
T
V
K
G
K
G
W
D
G
L
R
E
P
S
D
I
L
D
V
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
P
L
S
I
R
G
-
G
-
Q
-
L
K
G
-
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
N
I
E
K
D
G
-----
L
-----
T
V
S
I
E
G
G
Q
M
L
T
G
Q
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
L
E
V
L
K
Q
M
G
A
T
L
---
A
M
E
N
E
R
V
Q
G
G
E
P
V
A
D
L
T
I
E
T
-
S
-
V
L
Q
G
V
E
I
G
G
D
I
I
P
R
L
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
-----
V
K
E
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
P
------
T
P
-------
L
K
G
-----
G
-
V
T
V
S
S
H
G
D
H
R
I
G
M
A
M
A
I
A
A
L
-
L
A
E
K
-
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
F
D
H
L
D
R
L
K
S
E
A
21
PsiBlast_CBE
94.63
68%
-107
- C7 -
3RMT
3
AROA1_BACHD
D:
[15-434]
---------
L
K
G
T
I
K
V
P
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
E
--
Q
-
A
E
E
R
V
T
V
K
G
K
G
W
D
G
L
R
E
P
S
D
I
L
D
V
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
P
L
S
I
R
G
-
G
-
Q
-
L
K
G
-
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
N
I
E
K
D
G
-----
L
-----
T
V
S
I
E
G
G
Q
M
L
T
G
Q
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
L
E
V
L
K
Q
M
G
A
T
L
---
A
M
E
N
E
R
V
Q
G
G
E
P
V
A
D
L
T
I
E
T
-
S
-
V
L
Q
G
V
E
I
G
G
D
I
I
P
R
L
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
A
E
E
-----
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
P
------
T
P
-------
L
K
G
-----
G
-
V
T
V
S
S
H
G
D
H
R
I
G
M
A
M
A
I
A
A
L
-
L
A
E
K
-
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
F
D
H
L
D
R
L
K
S
E
A
22
PsiBlast_CBE
94.59
68%
-105
- C7 -
3RMT
6
AROA1_BACHD
C:
[15-434]
---------
L
K
G
T
I
K
V
P
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
E
--
Q
-
A
E
E
R
V
T
V
K
G
K
G
W
D
G
L
R
E
P
S
D
I
L
D
V
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
P
L
S
I
R
G
-
G
-
Q
-
L
K
G
-
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
N
I
E
K
D
G
-----
L
-----
T
V
S
I
E
G
G
Q
M
L
T
G
Q
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
L
E
V
L
K
Q
M
G
A
T
L
---
A
M
E
N
E
R
V
Q
G
G
E
P
V
A
D
L
T
I
E
T
-
S
-
V
L
Q
G
V
E
I
G
G
D
I
I
P
R
L
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
A
E
E
L
K
V
K
E
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
P
------
T
P
-------
L
K
G
-----
G
-
V
T
V
S
S
H
G
D
H
R
I
G
M
A
M
A
I
A
A
L
-
L
A
E
K
-
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
F
D
H
L
D
R
L
K
S
E
A
42
HHSearch
93.09
67%
-93
- C7 -
3RMT
9
AROA1_BACHD
A:
[8-433]
-
V
I
P
-
H
A
K
G
L
K
G
T
I
K
V
P
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
E
--
Q
-
A
E
E
R
V
T
V
K
G
K
G
W
D
G
L
R
E
P
S
D
I
L
D
V
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
P
L
S
I
R
G
-
G
-
Q
-
L
K
G
-
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
N
I
E
K
D
G
-----
L
-----
T
V
S
I
E
G
G
Q
M
L
T
G
Q
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
L
E
V
L
K
Q
M
G
A
T
L
---
A
M
E
N
E
R
V
Q
G
G
E
P
V
A
D
L
T
I
E
T
-
S
-
V
L
Q
G
V
E
I
G
G
D
I
I
P
R
L
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
-----
V
K
E
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
P
------
T
P
-------
L
-
K
-----
G
G
V
T
V
S
S
H
G
D
H
R
I
G
M
A
M
A
I
A
A
L
-
L
A
E
K
-
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
F
D
H
L
D
R
L
K
S
E
-
3
PsiBlast_PDB
83.40
52%
-38
- C7 -
1RF5
-
AROA_STRPN
A:
[4-424]
--
K
T
-
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
-
T
K
N
-
L
R
P
-
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
V
A
K
S
A
T
-----
L
I
V
E
S
-
S
-
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
A
-------
L
H
------
G
-
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
----
25
PsiBlast_CBE
81.47
52%
-32
- C7 -
1RF6
2
AROA_STRPN
C:
[4-424]
--
K
T
-
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
-
T
K
N
-
L
R
P
-
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
EIT
E
I
D
P
V
A
K
S
A
T
-----
L
I
V
E
S
-
S
-
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
A
-------
L
H
------
G
-
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
----
24
PsiBlast_CBE
81.11
52%
-29
- C7 -
1RF6
2
AROA_STRPN
D:
[4-424]
--
K
T
-
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
-
T
K
N
-
L
R
P
-
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
EIT
E
I
D
P
V
A
K
S
A
T
-----
L
I
V
E
S
-
S
-
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
A
-------
L
H
------
G
-
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
----
26
PsiBlast_CBE
80.92
52%
-31
- C7 -
1RF6
2
AROA_STRPN
B:
[4-424]
--
K
T
-
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
-
T
K
N
-
L
R
P
-
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
EIT
E
I
D
P
V
A
K
S
A
T
-----
L
I
V
E
S
-
S
-
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
A
-------
L
H
------
G
-
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
----
4
PsiBlast_PDB
80.78
52%
-32
- C7 -
1RF6
2
AROA_STRPN
A:
[4-424]
--
K
T
-
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
-
T
K
N
-
L
R
P
-
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
T
E
I
D
P
V
A
K
S
A
T
-----
L
I
V
E
S
-
S
-
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
A
-------
L
H
------
G
-
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
----
28
PsiBlast_CBE
80.76
52%
-31
- C7 -
1RF4
1
AROA_STRPN
C:
[4-424]
--
K
T
-
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
-
T
K
N
-
L
R
P
-
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
EIT
E
I
D
P
V
A
K
S
A
T
-----
L
I
V
E
S
-
S
-
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
A
-------
L
H
------
G
-
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
----
27
PsiBlast_CBE
80.72
52%
-30
- C7 -
1RF4
1
AROA_STRPN
D:
[4-424]
--
K
T
-
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
-
T
K
N
-
L
R
P
-
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
EIT
E
I
D
P
V
A
K
S
A
T
-----
L
I
V
E
S
-
S
-
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
A
-------
L
H
------
G
-
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
----
2
PsiBlast_PDB
80.14
52%
-29
- C7 -
1RF4
1
AROA_STRPN
A:
[4-424]
--
K
T
-
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
-
T
K
N
-
L
R
P
-
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
EIT
E
I
D
P
V
A
K
S
A
T
-----
L
I
V
E
S
-
S
-
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
A
-------
L
H
------
G
-
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
----
29
PsiBlast_CBE
80.02
52%
-30
- C7 -
1RF4
1
AROA_STRPN
B:
[4-424]
--
K
T
-
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
-
T
K
N
-
L
R
P
-
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
EIT
E
I
D
P
V
A
K
S
A
T
-----
L
I
V
E
S
-
S
-
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
A
-------
L
H
------
G
-
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
----
9
PsiBlast_PDB
78.44
48%
-40
- C7 -
4N3P
11
?
A:
[5-425]
--
K
T
-
N
I
R
H
L
H
G
I
I
R
V
P
G
D
S
S
I
S
V
L
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
A
S
I
V
A
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
-
T
K
N
-
L
R
P
-
I
H
Y
E
L
P
I
A
S
N
S
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
S
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
E
E
T
L
T
G
I
I
D
V
I
R
A
M
G
G
K
L
EIT
E
I
D
P
V
A
K
S
A
T
-----
L
I
V
E
S
-
S
-
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
A
-------
L
H
------
G
-
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
----
P
S
F
F
D
D
L
E
S
L
----
40
HHSearch
74.15
53%
19
- C7 -
1RF6
2
AROA_STRPN
A:
[1-426]
M
K
L
K
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
-
K
D
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
-
T
K
N
-
L
R
P
-
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
---
E
I
T
E
I
D
--
P
V
A
K
S
A
T
L
I
V
E
S
-
S
-
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
------
S
A
-------
L
-
H
-----
G
-
A
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
L
V
A
D
G
-
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
--
38
PsiBlast_CBE
73.25
46%
-3
- C7 -
3ROI
9
AROA_COXBU
B:
[12-428]
-------
Q
G
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
-
D
E
N
I
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
--
S
T
G
N
V
P
P
L
K
I
Y
G
N
P
-
R
-
L
T
G
-
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
K
D
K
-----
Q
-----
S
I
C
V
S
G
G
G
K
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
---
E
V
T
H
Y
T
E
K
-
E
E
P
T
A
D
I
T
V
R
H
-
A
-
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
-------
T
-------
L
E
G
-----
G
--
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
-
L
A
K
G
-
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
L
A
N
E
V
----
5
PsiBlast_PDB
72.51
46%
-6
- C7 -
3ROI
13
AROA_COXBU
A:
[12-428]
-------
Q
G
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
-
D
E
N
I
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
--
S
T
G
N
V
P
P
L
K
I
Y
G
N
P
-
R
-
L
T
G
-
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
--------------
S
I
C
V
S
G
G
G
K
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
---
E
V
T
H
Y
T
E
K
N
E
-
P
T
A
D
I
T
V
R
H
-
A
-
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
-------
T
-------
L
E
G
-----
G
--
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
-
L
A
K
G
-
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
L
A
N
E
V
----
11
PsiBlast_PDB
71.54
46%
5
- C7 -
5BUF
2
?
A:
[24-449]
-------
K
A
F
K
G
K
F
T
V
P
G
D
K
S
V
S
H
R
S
I
M
F
G
A
I
A
E
G
T
T
H
V
T
G
F
L
E
G
E
D
A
L
A
T
L
Q
A
F
R
D
M
G
V
S
I
E
G
-
P
-
K
N
G
E
V
T
I
H
G
V
G
M
H
G
L
K
A
P
A
S
A
L
Y
M
G
N
S
G
T
S
M
R
L
L
S
G
M
L
S
A
Q
K
F
D
S
V
M
T
G
D
A
S
L
S
K
R
P
M
E
R
I
A
K
P
L
R
L
M
G
A
Q
I
Q
T
T
G
E
K
G
T
P
P
V
S
I
T
G
-
G
-
Q
Q
L
K
G
-
I
Q
Y
D
L
P
M
A
S
A
Q
V
K
S
G
I
L
L
A
G
L
W
A
E
G
E
T
S
V
T
E
P
E
P
T
R
D
H
T
E
R
M
L
R
A
F
G
Y
D
V
K
T
E
G
-----
N
-----
K
I
S
L
V
G
G
G
K
L
V
G
T
N
I
Q
V
P
S
D
I
S
S
A
A
F
F
M
V
G
A
A
I
T
E
G
A
D
V
V
L
E
A
V
G
I
N
P
T
R
T
G
V
I
E
I
L
K
Q
M
G
A
D
L
---
T
V
E
N
E
R
I
A
G
G
E
P
I
A
D
I
H
I
K
G
-
S
R
T
L
K
G
I
H
M
P
E
D
Q
V
P
L
A
I
D
E
F
P
A
L
F
I
A
A
A
C
A
E
G
Q
T
V
L
T
G
A
A
E
L
R
V
K
E
S
D
R
I
Q
V
M
A
D
G
L
K
I
M
G
I
D
C
T
P
T
E
D
G
I
I
I
E
G
K
GKSGDW
S
P
-------
I
F
A
-----
G
-
G
E
I
E
S
H
H
D
H
R
I
A
M
S
F
S
M
A
G
L
-
R
T
S
G
-
P
I
T
I
H
G
T
E
T
V
A
T
S
F
P
T
F
T
E
L
A
N
R
-----
44
HHSearch
71.42
46%
8
- C7 -
5BUF
2
?
A:
[20-453]
--
L
P
-
G
N
K
A
F
K
G
K
F
T
V
P
G
D
K
S
V
S
H
R
S
I
M
F
G
A
I
A
E
G
T
T
H
V
T
G
F
L
E
G
E
D
A
L
A
T
L
Q
A
F
R
D
M
G
V
S
I
E
--
G
P
K
N
G
E
V
T
I
H
G
V
G
M
H
G
L
K
A
P
A
S
A
L
Y
M
G
N
S
G
T
S
M
R
L
L
S
G
M
L
S
A
Q
K
F
D
S
V
M
T
G
D
A
S
L
S
K
R
P
M
E
R
I
A
K
P
L
R
L
M
G
A
Q
I
Q
T
T
G
E
K
G
T
P
P
V
S
I
T
G
-
G
Q
Q
-
L
K
G
-
I
Q
Y
D
L
P
M
A
S
A
Q
V
K
S
G
I
L
L
A
G
L
W
A
E
G
E
T
S
V
T
E
P
E
P
T
R
D
H
T
E
R
M
L
R
A
F
G
Y
D
V
K
T
E
G
-----
N
-----
K
I
S
L
V
G
G
G
K
L
V
G
T
N
I
Q
V
P
S
D
I
S
S
A
A
F
F
M
V
G
A
A
I
T
E
G
A
D
V
V
L
E
A
V
G
I
N
P
T
R
T
G
V
I
E
I
L
K
Q
M
G
A
D
L
---
T
V
E
N
E
R
I
A
G
G
E
P
I
A
D
I
H
I
K
G
S
R
-
T
L
K
G
I
H
M
P
E
D
Q
V
P
L
A
I
D
E
F
P
A
L
F
I
A
A
A
C
A
E
G
Q
T
V
L
T
G
A
A
E
L
R
V
K
E
S
D
R
I
Q
V
M
A
D
G
L
K
I
M
G
I
D
C
T
P
T
E
D
G
I
I
I
E
G
K
------
G
K
SGDWSPI
F
-
A
-----
G
-
G
E
I
E
S
H
H
D
H
R
I
A
M
S
F
S
M
A
G
L
-
R
T
S
G
-
P
I
T
I
H
G
T
E
T
V
A
T
S
F
P
T
F
T
E
L
A
N
R
A
G
L
T
-
8
PsiBlast_PDB
71.20
46%
1
- C7 -
4ZND
5
AROA_COXBU
A:
[12-428]
-------
Q
G
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
VI
E
-
D
E
N
I
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
--
S
T
G
N
V
P
P
L
K
I
Y
G
N
P
-
R
-
L
T
G
-
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
K
D
K
-----
Q
-----
S
I
C
V
S
G
G
G
K
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
---
E
V
T
H
Y
T
E
K
N
E
E
P
T
A
D
I
T
V
R
H
-
A
-
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
-------
T
-------
L
E
G
-----
G
--
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
-
L
A
K
G
-
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
L
A
N
E
V
----
17
PsiBlast_PDB
70.96
41%
-7
- C7 -
2GGA
2
AROA_AGRSC
A:
[14-446]
-----
K
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
-
E
G
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
D
G
D
R
L
-
P
V
T
L
R
G
-
P
-
K
-
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
ADG
V
R
-----
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
---
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
-
S
-
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
------
P
D
-------
G
K
G
LGNAS
G
-
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
L
-
V
S
E
N
-
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
-
13
PsiBlast_PDB
70.93
41%
-6
- C7 -
2GGD
2
AROA_AGRSC
A:
[14-446]
-----
K
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
-
E
G
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
G
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
D
G
D
R
L
-
P
V
T
L
R
G
-
P
-
K
-
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
ADG
V
R
-----
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
---
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
-
S
-
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
------
P
D
-------
G
K
G
LGNAS
G
-
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
L
-
V
S
E
N
-
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
-
14
PsiBlast_PDB
70.82
41%
-6
- C7 -
2PQD
1
AROA_AGRSC
A:
[9-441]
-----
K
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
-
E
G
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
G
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
D
G
D
R
L
-
P
V
T
L
R
G
-
P
-
K
-
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
ADG
V
R
-----
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
---
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
-
S
-
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
------
P
D
-------
G
K
G
LGNAS
G
-
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
L
-
V
S
E
N
-
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
-
19
PsiBlast_PDB
70.41
41%
-7
- C7 -
2PQC
1
AROA_AGRSC
A:
[9-441]
-----
K
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
-
E
G
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
D
G
D
R
L
-
P
V
T
L
R
G
-
P
-
K
-
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
ADG
V
R
-----
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
---
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
-
S
-
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
------
P
D
-------
G
K
G
LGNAS
G
-
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
L
-
V
S
E
N
-
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
-
18
PsiBlast_PDB
70.33
41%
-6
- C7 -
2PQB
1
AROA_AGRSC
A:
[9-441]
-----
K
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
-
E
G
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
D
G
D
R
L
-
P
V
T
L
R
G
-
P
-
K
-
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
ADG
V
R
-----
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
---
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
-
S
-
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
------
P
D
-------
G
K
G
LGNAS
G
-
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
L
-
V
S
E
N
-
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
-
16
PsiBlast_PDB
69.98
41%
-5
- C7 -
2GG6
3
AROA_AGRSC
A:
[14-446]
-----
K
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
-
E
G
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
D
G
D
R
L
-
P
V
T
L
R
G
-
P
-
K
-
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
ADG
V
R
-----
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
---
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
-
S
-
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
------
P
D
-------
G
K
G
LGNAS
G
-
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
L
-
V
S
E
N
-
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
-
41
HHSearch
69.80
42%
-4
- C7 -
2PQC
1
AROA_AGRSC
A:
[6-441]
-
T
A
R
-
K
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
-
E
G
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
-
E
D
G
D
R
L
P
V
T
L
R
G
-
P
K
T
-
P
T
P
-
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
-----
D
ADG
V
R
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
---
E
V
I
N
P
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
-
S
-
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
------
P
D
GKGLGN-
A
-
S
-----
G
-
A
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
L
-
V
S
E
N
-
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
-