@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22610: (2016-07-05 )
MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAVAALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGSTKQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAVEQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFAAGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRYFKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIETREDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD
Atome Classification :
(20 SA)
.........10........20........30-.--........40........50........60-.......--.70........80.......-.90........100.......110...-..-..120.......130.......140.......150.......160.......170.......180.......190.......200....-...210.-......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNQ
M
K
D
T
I
L
L
A
G
L
G
LIGG
S
I
A
L
A
I
KKNHPG--
K
--
R
I
I
G
I
DISDEQ
A
V
A
A
L
K
L
G
VIDDR
A
D
S
F
I
S
-
G
V
K
E
A
A
T
--
V
I
I
AT
P
V
E
Q
T
L
V
M
L
E
E
L
A
HS-GIE
H
E
L
L
I
TDVGS
T
K
Q
K
V
V
D
Y
A
D
Q
VLP-SR-
Y
Q
FVGGHPMAGSHK
S
G
V
A
A
A
K
E
F
L
F
EN
A
F
Y
I
LTPGQKT
D
K
Q
A
V
E
Q
L
K
N
L
L
KGTN
A
H
F
V
EMSPEEHD
G
V
T
S
V
I
S
H
F
P
H
I
V
A
A
S
L
V
H
QTHH-SE
N
L
Y
P
L
-
V
K
R
F
AAG
G
F
R
D
I
T
R
I
ASSS
P
A
M
W
R
D
I
L
LH
N
K
D
K
I
L
D
R
F
D
E
W
I
R
E
I
D
K
I
R
T
Y
V
E
Q
E
D
A
E
N
L
F
R
Y
F
K
T
A
K
D
Y
RDGLPLRQKGAIP
A
F
Y
D
L
Y
V
DVPDHP
G
V
I
S
E
I
T
A
I
L
A
A
E
R
I
S
I
T
N
I
R
I
I
ETREDIN
G
I
L
R
I
S
FQSD
D
D
R
K
R
A
E
Q
C
I
E
A
R
A
E
Y
E
TFYAD
2
PsiBlast_PDB
80.34
41%
-83
- C3 -
3B1F
1
?
A:
[8-286]
------
T
I
Y
I
A
G
L
G
L
I
G
A
S
L
A
L
G
I
K
R
D
H
P
H
--
Y
--
K
I
V
G
Y
N
R
S
D
R
S
R
D
I
A
L
E
R
G
I
V
D
E
A
T
A
D
F
K
V
-
F
A
A
L
A
D
V
--
I
I
L
A
V
P
I
K
K
T
I
D
F
I
K
I
L
A
D
L
-
D
L
K
E
D
V
I
I
T
D
A
G
S
T
K
Y
E
I
V
R
A
A
E
Y
Y
L
K
-
D
K
P
V
Q
F
V
G
S
H
P
M
A
----
S
G
A
V
A
A
N
V
N
L
F
E
N
A
Y
Y
I
F
S
P
S
C
L
T
K
P
N
T
I
P
A
L
Q
D
L
L
S
G
L
H
A
R
Y
V
E
I
D
A
A
E
H
D
C
V
T
S
Q
I
S
H
F
P
H
I
I
A
S
S
L
M
K
Q
A
G
D
-
F
S
E
S
H
E
M
-
T
K
H
F
A
A
G
G
F
R
D
M
T
R
I
A
E
S
E
P
G
M
W
T
S
I
L
L
T
N
Q
E
A
V
L
D
R
I
E
N
F
K
Q
R
L
D
E
V
S
N
L
I
K
A
R
D
E
N
A
I
W
A
F
F
N
Q
S
R
Q
I
R
---------------------------------------------------------------------------------------
1
PsiBlast_PDB
79.28
41%
-68
- C3 -
3DZB
-
?
A:
[4-298]
-----
K
T
I
Y
I
A
G
L
G
L
I
G
G
S
L
A
L
G
I
K
R
D
H
P
D
--
Y
--
E
I
L
G
Y
N
R
S
D
Y
S
R
N
I
A
L
E
R
G
I
V
D
R
A
T
G
D
F
K
E
-
F
A
P
L
A
D
V
--
I
I
L
A
V
P
I
K
Q
T
M
A
Y
L
K
E
L
A
D
L
-
D
L
K
D
N
V
I
I
T
D
A
G
S
T
K
R
E
I
V
E
A
A
E
R
Y
L
T
-
G
K
N
V
Q
F
V
G
S
H
P
M
A
G
S
------
A
A
D
V
T
L
F
E
N
A
Y
Y
I
F
T
P
T
S
L
T
K
E
T
T
I
P
E
L
K
D
I
L
S
G
L
K
S
R
Y
V
E
I
D
A
A
E
H
D
R
V
T
S
Q
I
S
H
F
P
H
L
L
A
S
G
L
M
E
Q
A
A
D
-
Y
A
Q
A
H
E
M
-
T
N
H
F
A
A
G
G
F
R
D
M
T
R
I
A
E
S
E
P
G
M
W
A
S
I
L
M
T
N
G
P
A
V
L
D
R
I
E
D
F
K
K
R
L
D
H
V
A
D
L
I
K
A
E
D
E
S
A
I
W
E
F
F
D
N
G
R
K
K
R
K
E
M
E
I
H
K
K
G
G
V
E
S
A
F
------------------------------------------------------------------------
46
HHSearch
77.16
41%
-6
- C3 -
3B1F
1
?
A:
[2-289]
A
A
M
E
E
K
T
I
Y
I
A
G
L
G
L
I
G
A
S
L
A
L
G
I
K
R
D
--
H
PH
Y
--
K
I
V
G
Y
N
R
S
D
R
S
R
D
I
A
L
E
R
G
I
V
D
E
A
T
A
D
F
K
V
-
F
A
A
L
A
D
V
--
I
I
L
A
V
P
I
K
K
T
I
D
F
I
K
I
L
A
D
L
D
L
-
K
E
D
V
I
I
T
D
A
G
S
T
K
Y
E
I
V
R
A
A
E
Y
Y
L
K
D
K
P
-
V
Q
F
V
G
S
H
P
M
A
----
S
G
A
V
A
A
N
V
N
L
F
E
N
A
Y
Y
I
F
S
P
S
C
L
T
K
P
N
T
I
P
A
L
Q
D
L
L
S
G
L
H
A
R
Y
V
E
I
D
A
A
E
H
D
C
V
T
S
Q
I
S
H
F
P
H
I
I
A
S
S
L
M
K
Q
A
G
D
-
F
S
E
S
H
E
M
-
T
K
H
F
A
A
G
G
F
R
D
M
T
R
I
A
E
S
E
P
G
M
W
T
S
I
L
L
T
N
Q
E
A
V
L
D
R
I
E
N
F
K
Q
R
L
D
E
V
S
N
L
I
K
A
R
D
E
N
A
I
W
A
F
F
N
Q
S
R
Q
I
R
K
N
M
------------------------------------------------------------------------------------
6
PsiBlast_PDB
76.35
34%
-105
- C3 -
4WJI
6
?
A:
[2-283]
--
Q
Q
F
Q
T
I
A
L
I
G
I
G
L
I
G
S
S
I
A
R
D
I
R
E
K
Q
L
A
--
G
--
T
I
V
V
T
T
R
S
E
A
T
L
K
R
A
G
E
L
G
L
G
D
R
Y
T
L
S
A
A
E
-
A
V
E
G
A
D
L
--
V
V
V
S
V
P
V
G
A
S
G
A
V
A
A
E
I
A
-
A
-
H
L
K
P
G
A
I
V
T
D
V
G
S
T
K
G
S
V
I
A
Q
M
A
P
H
L
P
-
K
D
-
V
H
F
V
P
G
H
P
I
A
G
T
E
H
S
G
P
D
A
G
F
A
G
L
F
R
G
R
W
C
I
L
T
P
P
A
G
T
D
E
E
A
V
A
R
L
R
L
F
W
E
T
L
G
S
M
V
D
E
M
D
P
K
H
H
D
K
V
L
A
I
V
S
H
L
P
H
I
I
A
Y
N
I
V
G
T
A
D
D
-
L
E
T
V
T
E
S
E
V
I
K
Y
S
A
S
G
F
R
D
F
T
R
L
A
A
S
D
P
T
M
W
R
D
V
C
L
H
N
K
D
A
I
L
E
M
L
A
R
F
S
E
D
L
A
S
L
Q
R
A
I
R
W
G
D
G
D
K
L
F
D
L
F
T
R
T
R
A
I
R
---------------------------------------------------------------------------------------
27
PsiBlast_CBE
70.29
35%
14
- C3 -
3GGG
2
?
C:
[35-308]
------
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
--
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
-
I
A
-
K
V
E
D
F
S
P
DF
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
N
I
L
G
-
K
R
---
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
T
D
K
K
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
-
M
S
T
P
E
V
D
-
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
-----------------------------------------------------------------------------------------
5
PsiBlast_PDB
69.80
35%
11
- C3 -
3GGP
3
?
A:
[35-310]
------
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
--
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
-
I
A
-
K
V
E
D
F
S
P
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
N
I
L
G
-
K
R
---
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
T
D
K
K
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
-
M
S
T
P
E
V
D
-
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
---------------------------------------------------------------------------------------
45
HHSearch
69.64
34%
22
* C3 *
4WJI
6
?
A:
[1-289]
-
A
Q
Q
F
Q
T
I
A
L
I
G
I
G
L
I
G
S
S
I
A
R
D
I
R
E
K
--
Q
--
L
AG
T
I
V
V
T
T
R
S
E
A
T
L
K
R
A
G
E
L
G
L
G
D
R
Y
T
L
S
A
A
E
-
A
V
E
G
A
D
L
--
V
V
V
S
V
P
V
G
A
S
G
A
V
A
A
E
I
A
A
H
-
L
-
K
P
G
A
I
V
T
D
V
G
S
T
K
G
S
V
I
A
Q
M
A
P
H
L
P
-
K
D
-
V
H
F
V
P
G
H
P
I
A
G
T
E
H
S
G
P
D
A
G
F
A
G
L
F
R
G
R
W
C
I
L
T
P
P
A
G
T
D
E
E
A
V
A
R
L
R
L
F
W
E
T
L
G
S
M
V
D
E
M
D
P
K
H
H
D
K
V
L
A
I
V
S
H
L
P
H
I
I
A
Y
N
I
V
G
T
A
D
D
L
E
T
V
T
E
S
E
-
V
I
K
Y
S
A
S
G
F
R
D
F
T
R
L
A
A
S
D
P
T
M
W
R
D
V
C
L
H
N
K
D
A
I
L
E
M
L
A
R
F
S
E
D
L
A
S
L
Q
R
A
I
R
W
G
D
G
D
K
L
F
D
L
F
T
R
T
R
A
I
R
R
S
I
V
Q
A
---------------------------------------------------------------------------------
22
PsiBlast_CBE
69.42
35%
15
- C3 -
3GGP
3
?
C:
[35-310]
------
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
--
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
-
I
A
-
K
V
E
D
F
S
P
DF
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
N
I
L
G
-
K
R
---
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
T
D
K
K
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
-
M
S
T
P
E
V
D
-
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
---------------------------------------------------------------------------------------
4
PsiBlast_PDB
69.24
35%
10
- C3 -
3GGO
2
?
A:
[35-310]
------
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
--
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
-
I
A
-
K
V
E
D
F
S
P
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
N
I
L
G
-
K
R
---
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
T
D
K
K
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
-
M
S
T
P
E
V
D
-
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
---------------------------------------------------------------------------------------
23
PsiBlast_CBE
69.20
35%
9
- C3 -
3GGP
3
?
B:
[35-310]
------
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
--
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
-
I
A
-
K
V
E
D
F
S
P
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
N
I
L
G
-
K
R
---
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
T
D
K
K
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
-
M
S
T
P
E
V
D
-
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
---------------------------------------------------------------------------------------
21
PsiBlast_CBE
69.13
35%
17
- C3 -
3GGP
3
?
D:
[35-310]
------
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
--
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
-
I
A
-
K
V
E
D
F
S
P
DF
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
N
I
L
G
-
K
R
---
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
T
D
K
K
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
-
M
S
T
P
E
V
D
-
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
---------------------------------------------------------------------------------------
25
PsiBlast_CBE
68.98
35%
16
- C3 -
3GGO
2
?
C:
[35-308]
------
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
--
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
-
I
A
-
K
V
E
D
F
S
P
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
N
I
L
G
-
K
R
---
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
T
D
K
K
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
-
M
S
T
P
E
V
D
-
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
-----------------------------------------------------------------------------------------
24
PsiBlast_CBE
68.93
35%
12
- C3 -
3GGO
2
?
D:
[35-310]
------
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
--
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
-
I
A
-
K
V
E
D
F
S
P
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
N
I
L
G
-
K
R
---
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
T
D
K
K
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
-
M
S
T
P
E
V
D
-
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
---------------------------------------------------------------------------------------
29
PsiBlast_CBE
68.86
35%
11
- C3 -
3GGG
2
?
A:
[35-310]
------
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
--
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
-
I
A
-
K
V
E
D
F
S
P
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
N
I
L
G
-
K
R
---
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
T
D
K
K
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
-
M
S
T
P
E
V
D
-
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
---------------------------------------------------------------------------------------
3
PsiBlast_PDB
68.69
35%
14
- C3 -
3GGG
2
?
D:
[35-310]
------
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
--
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
-
I
A
-
K
V
E
D
F
S
P
DF
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
N
I
L
G
-
K
R
---
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
T
D
K
K
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
-
M
S
T
P
E
V
D
-
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
---------------------------------------------------------------------------------------
47
HHSearch
68.40
34%
15
- C3 -
3GGO
2
?
A:
[31-313]
--
L
S
M
Q
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
--
G
--
F
K
G
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
I
A
K
V
E
D
F
S
P
D
F
--
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
I
-
L
-
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
N
I
L
---
G
-
K
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
T
D
K
K
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
-
M
S
T
P
E
V
D
-
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
E
I
------------------------------------------------------------------------------------
26
PsiBlast_CBE
67.97
35%
9
- C3 -
3GGO
2
?
B:
[35-310]
------
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
--
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
-
I
A
-
K
V
E
D
F
S
P
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
N
I
L
G
-
K
R
---
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
T
D
K
K
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
-
M
S
T
P
E
V
D
-
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
---------------------------------------------------------------------------------------
44
HHSearch
67.66
35%
24
- C3 -
2G5C
1
?
A:
[1-281]
----
M
Q
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
--
G
--
F
K
G
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
I
A
K
V
E
D
F
S
P
D
F
--
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
I
-
L
-
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
N
I
L
---
G
-
K
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
T
D
K
K
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
-
M
S
T
P
E
V
D
-
L
F
K
Y
P
G
G
G
F
K
D
F
---
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
E
I
------------------------------------------------------------------------------------
28
PsiBlast_CBE
67.29
35%
11
- C3 -
3GGG
2
?
B:
[35-310]
------
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
--
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
-
I
A
-
K
V
E
D
F
S
P
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
N
I
L
G
-
K
R
---
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
T
D
K
K
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
-
M
S
T
P
E
V
D
-
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
---------------------------------------------------------------------------------------
7
PsiBlast_PDB
67.29
34%
17
- C3 -
2G5C
1
?
A:
[3-278]
------
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
--
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
-
I
A
-
K
V
E
D
F
S
P
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
N
I
L
G
-
K
R
---
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
T
D
K
K
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
-
M
S
T
P
E
V
D
-
L
F
K
Y
P
G
G
G
F
K
D
F
---
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
---------------------------------------------------------------------------------------