@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22670: (2016-07-05 )
MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILAHRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGAKIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHVAGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSSRDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNIFENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEEEIYA
Atome Classification :
(66 SA)
.........10........20........30........40........50........60-....--.....70--..-.......80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280--........290.......300-------..------.....310.......320.......330......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNR
F
L
Q
L
C
VDGKTLTAG
E
A
E
T
L
M
N
M
M
M
A
AEM
T
P
S
EM
G
G
I
L
S
I
L
A
HRGE
T
P
E
E
L
A
G
F
V
K
A
M
--
R
A
H
A
--
L
TVDGL---
P
D
-
I
V
D
TCGTGGDG
I
S
T
F
N
I
S
T
A
S
A
I
V
A
SAAG
A
K
I
A
KHGNRSVSSKSG
S
A
D
V
L
E
E
L
E
V
S
IQT
T
P
E
K
V
K
S
SIETNN
M
G
F
L
F
A
P
L
Y
H
S
S
M
K
H
V
AG
T
R
K
EL
G
F
R
T
V
F
N
L
L
GPLS
N
P
L
Q
A
K
R
Q
V
I
G
V
Y
S
V
E
K
A
G
L
M
A
S
A
L
E
TFQP
K
H
V
M
F
VSSRDGLDELSITAP
T
D
V
I
ELKDGERR
E
Y
TVSPEDFGFTNG
R
L
E
D
L
Q
VQSP
K
E
S
A
Y
L
I
Q
N
I
F
ENKS---SS
S
A
L
S
I
T
A
FNAG
A
A
I
Y
TAG
I
-------
T
A------SLKEG
T
E
L
A
L
E
T
ITSG
G
A
A
A
Q
L
E
R
L
K
Q
K
E
E
E
IYA
90
HHSearch
93.14
36%
-104
- C7 -
1O17
-
TRPD_SULSO
A:
[3-334]
I
N
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
--
R
E
L
A
--
I
K
I
D
V
----
P
N
-
A
I
D
T
A
G
----
G
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
-
L
V
N
P
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
F
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
----
D
E
H
V
A
E
F
I
K
I
N
T
A
V
A
L
F
A
L
D
R
-------
V
G
------
D
F
R
E
G
Y
E
Y
A
D
H
L
I
E
--
K
S
L
D
K
L
N
E
I
I
S
M
N
G
D
V
T
-
30
PsiBlast_CBE
89.48
38%
-98
- C7 -
1ZXY
3
TRPD_SULSO
B:
[3-312]
I
N
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
--
R
E
L
A
--
I
K
I
D
-
V
---
P
N
-
A
I
D
T
A
G
T
G
G
D
G
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
L
V
N
P
-
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
F
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
D
---
E
H
V
A
-
E
F
I
K
I
N
T
A
V
A
L
F
A
L
D
R
-------
V
G
------
D
F
R
E
G
Y
E
Y
A
-------------------------
6
PsiBlast_PDB
89.28
38%
-110
- C7 -
1O17
-
TRPD_SULSO
A:
[3-312]
I
N
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
--
R
E
L
A
--
I
K
I
D
-
V
---
P
N
-
A
I
D
T
A
G
----
G
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
L
V
N
P
-
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
F
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
D
---
E
H
V
A
-
E
F
I
K
I
N
T
A
V
A
L
F
A
L
D
R
-------
V
G
------
D
F
R
E
G
Y
E
Y
A
-------------------------
22
PsiBlast_CBE
89.27
38%
-103
- C7 -
2GVQ
2
TRPD_SULSO
D:
[3-312]
I
N
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
--
R
E
L
A
--
I
K
I
D
-
V
---
P
N
-
A
I
D
T
A
G
T
G
G
D
G
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
L
V
N
P
-
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
F
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
D
---
E
H
V
A
-
E
F
I
K
I
N
T
A
V
A
L
F
A
L
D
R
-------
V
G
------
D
F
R
E
G
Y
E
Y
A
-------------------------
27
PsiBlast_CBE
89.17
38%
-98
- C7 -
1ZYK
5
TRPD_SULSO
B:
[3-312]
I
N
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
--
R
E
L
A
--
I
K
I
D
-
V
---
P
N
-
A
I
D
T
A
G
T
G
G
D
G
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
L
V
N
P
-
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
F
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
D
---
E
H
V
A
-
E
F
I
K
I
N
T
A
V
A
L
F
A
L
D
R
-------
V
G
------
D
F
R
E
G
Y
E
Y
A
-------------------------
37
PsiBlast_CBE
89.14
37%
-103
- C7 -
3GBR
7
TRPD_SULSO
B:
[3-312]
I
N
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
--
R
E
L
A
--
I
K
I
D
-
V
---
P
N
-
A
I
D
T
A
G
T
G
G
G
G
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
L
V
N
P
-
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
S
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
D
---
E
H
V
A
-
E
F
I
K
I
N
T
A
V
A
L
F
A
L
D
R
-------
V
G
------
D
F
R
E
G
Y
E
Y
A
-------------------------
26
PsiBlast_CBE
89.12
38%
-98
- C7 -
1ZYK
5
TRPD_SULSO
C:
[3-312]
I
N
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
--
R
E
L
A
--
I
K
I
D
-
V
---
P
N
-
A
I
D
T
A
G
T
G
G
D
G
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
L
V
N
P
-
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
F
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
D
---
E
H
V
A
-
E
F
I
K
I
N
T
A
V
A
L
F
A
L
D
R
-------
V
G
------
D
F
R
E
G
Y
E
Y
A
-------------------------
23
PsiBlast_CBE
89.09
38%
-107
- C7 -
2GVQ
2
TRPD_SULSO
C:
[3-312]
I
N
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
--
R
E
L
A
--
I
K
I
D
-
V
---
P
N
-
A
I
D
T
A
G
----
G
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
L
V
N
P
-
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
F
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
D
---
E
H
V
A
-
E
F
I
K
I
N
T
A
V
A
L
F
A
L
D
R
-------
V
G
------
D
F
R
E
G
Y
E
Y
A
-------------------------
8
PsiBlast_PDB
88.96
38%
-97
- C7 -
1ZXY
3
TRPD_SULSO
A:
[3-312]
I
N
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
--
R
E
L
A
--
I
K
I
D
-
V
---
P
N
-
A
I
D
T
A
G
T
G
G
D
G
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
L
V
N
P
-
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
F
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
D
---
E
H
V
A
-
E
F
I
K
I
N
T
A
V
A
L
F
A
L
D
R
-------
V
G
------
D
F
R
E
G
Y
E
Y
A
-------------------------
10
PsiBlast_PDB
88.60
38%
-104
- C7 -
2GVQ
1
TRPD_SULSO
A:
[3-312]
I
N
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
--
R
E
L
A
--
I
K
I
D
-
V
---
P
N
-
A
I
D
T
A
G
T
G
---
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
L
V
N
P
-
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
F
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
D
---
E
H
V
A
-
E
F
I
K
I
N
T
A
V
A
L
F
A
L
D
R
-------
V
G
------
D
F
R
E
G
Y
E
Y
A
-------------------------
25
PsiBlast_CBE
88.43
38%
-95
- C7 -
1ZYK
5
TRPD_SULSO
D:
[3-312]
I
N
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
--
R
E
L
A
--
I
K
I
D
-
V
---
P
N
-
A
I
D
T
A
G
T
G
G
D
G
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
L
V
N
P
-
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
F
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
D
---
E
H
V
A
-
E
F
I
K
I
N
T
A
V
A
L
F
A
L
D
R
-------
V
G
------
D
F
R
E
G
Y
E
Y
A
-------------------------
29
PsiBlast_CBE
88.42
38%
-97
- C7 -
1ZXY
3
TRPD_SULSO
C:
[3-312]
I
N
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
--
R
E
L
A
--
I
K
I
D
-
V
---
P
N
-
A
I
D
T
A
G
T
G
G
D
G
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
L
V
N
P
-
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
F
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
D
---
E
H
V
A
-
E
F
I
K
I
N
T
A
V
A
L
F
A
L
D
R
-------
V
G
------
D
F
R
E
G
Y
E
Y
A
-------------------------
28
PsiBlast_CBE
88.20
38%
-98
- C7 -
1ZXY
3
TRPD_SULSO
D:
[3-312]
I
N
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
--
R
E
L
A
--
I
K
I
D
-
V
---
P
N
-
A
I
D
T
A
G
T
G
G
D
G
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
L
V
N
P
-
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
F
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
D
---
E
H
V
A
-
E
F
I
K
I
N
T
A
V
A
L
F
A
L
D
R
-------
V
G
------
D
F
R
E
G
Y
E
Y
A
-------------------------
33
PsiBlast_CBE
88.16
38%
-104
- C7 -
1GXB
1
TRPD_SULSO
B:
[3-312]
I
N
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
--
R
E
L
A
--
I
K
I
D
-
V
---
P
N
-
A
I
D
T
A
G
---
D
G
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
L
V
N
P
-
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
F
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
D
---
E
H
V
A
-
E
F
I
K
I
N
T
A
V
A
L
F
A
L
D
R
-------
V
G
------
D
F
R
E
G
Y
E
Y
A
-------------------------
24
PsiBlast_CBE
87.70
38%
-106
- C7 -
2GVQ
2
TRPD_SULSO
B:
[3-312]
I
N
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
--
R
E
L
A
--
I
K
I
D
-
V
---
P
N
-
A
I
D
T
A
G
T
G
---
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
L
V
N
P
-
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
F
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
D
---
E
H
V
A
-
E
F
I
K
I
N
T
A
V
A
L
F
A
L
D
R
-------
V
G
------
D
F
R
E
G
Y
E
Y
A
-------------------------
7
PsiBlast_PDB
87.52
38%
-106
- C7 -
1GXB
2
TRPD_SULSO
A:
[3-312]
I
N
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
--
R
E
L
A
--
I
K
I
D
-
V
---
P
N
-
A
I
D
T
A
G
----
G
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
L
V
N
P
-
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
F
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
D
---
E
H
V
A
-
E
F
I
K
I
N
T
A
V
A
L
F
A
L
D
R
-------
V
G
------
D
F
R
E
G
Y
E
Y
A
-------------------------
9
PsiBlast_PDB
87.34
38%
-100
- C7 -
1ZYK
5
TRPD_SULSO
A:
[3-312]
I
N
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
--
R
E
L
A
--
I
K
I
D
-
V
---
P
N
-
A
I
D
T
A
G
T
G
G
D
G
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
L
V
N
P
-
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
F
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
D
---
E
H
V
A
-
E
F
I
K
I
N
T
A
V
A
L
F
A
L
D
R
-------
V
G
------
D
F
R
E
G
Y
E
Y
A
-------------------------
31
PsiBlast_CBE
86.83
38%
-98
- C7 -
1GXB
2
TRPD_SULSO
D:
[3-312]
I
N
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
--
R
E
L
A
--
I
K
I
D
-
V
---
P
N
-
A
I
D
T
A
G
T
G
G
D
G
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
L
V
N
P
-
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
F
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
D
---
E
H
V
A
-
E
F
I
K
I
N
T
A
V
A
L
F
A
L
D
R
-------
V
G
------
D
F
R
E
G
Y
E
Y
A
-------------------------
32
PsiBlast_CBE
86.59
38%
-105
- C7 -
1GXB
2
TRPD_SULSO
C:
[3-312]
I
N
E
I
L
K
K
L
I
N
K
S
D
L
E
I
N
E
A
E
E
L
A
K
A
I
I
R
G
E
V
P
E
I
L
V
S
A
I
L
V
A
L
R
M
K
G
E
S
K
N
E
I
V
G
F
A
R
A
M
--
R
E
L
A
--
I
K
I
D
-
V
---
P
N
-
A
I
D
T
A
G
----
G
L
G
T
V
N
V
S
T
A
S
A
I
L
L
S
L
V
N
P
-
V
A
K
H
G
N
R
A
V
S
G
K
S
G
S
A
D
V
L
E
A
L
G
Y
N
I
I
V
P
P
E
R
A
K
E
L
V
N
K
T
N
F
V
F
L
F
A
Q
Y
Y
H
P
A
M
K
N
V
A
N
V
R
K
T
L
G
I
R
T
I
F
N
I
L
G
P
L
T
N
P
A
N
A
K
Y
Q
L
M
G
V
F
S
K
D
H
L
D
L
L
S
K
S
A
Y
E
L
D
F
N
K
I
I
L
V
Y
G
E
P
G
I
D
E
V
S
P
I
G
N
T
F
M
K
I
V
S
K
R
G
I
E
E
V
K
L
N
V
T
D
F
G
I
S
P
I
P
I
E
K
L
I
V
N
S
A
E
D
S
A
I
K
I
V
R
A
F
L
G
K
D
---
E
H
V
A
-
E
F
I
K
I
N
T
A
V
A
L
F
A
L
D
R
-------
V
G
------
D
F
R
E
G
Y
E
Y
A
-------------------------
85
HHSearch
84.42
40%
-19
- C7 -
4HKM
3
TRPD_XANCP
A:
[6-343]
P
Q
Q
A
L
Q
R
T
I
E
H
R
E
I
F
H
D
E
M
V
D
L
M
R
Q
I
M
R
G
E
V
S
D
A
M
V
S
A
I
L
T
G
L
R
V
K
K
E
T
I
G
E
I
A
G
A
A
T
V
M
--
R
E
F
S
--
R
R
V
E
V
T
DR-
R
H
-
M
V
D
I
V
G
T
------
T
F
N
I
S
T
C
A
M
F
V
A
A
A
G
G
A
K
V
A
K
H
G
---------
S
A
D
A
L
E
A
L
G
A
V
I
E
L
Q
P
E
Q
V
A
A
S
L
A
Q
T
G
I
G
F
M
Y
A
P
V
H
H
P
A
M
K
V
V
A
P
V
R
R
E
M
G
V
R
T
I
F
N
I
L
G
P
L
T
N
P
A
G
S
P
N
I
L
M
G
V
F
H
P
D
L
V
G
I
Q
A
R
V
L
Q
E
L
G
A
E
R
A
L
V
V
W
G
R
D
G
M
D
E
L
S
L
G
A
G
T
L
V
G
E
L
R
D
G
Q
V
H
E
Y
E
V
H
P
E
D
F
G
I
A
M
S
A
---------
A
E
S
R
A
M
L
L
Q
V
L
D
N
V
----
P
G
P
A
L
D
I
V
A
L
N
A
G
A
A
L
Y
V
A
G
V
-------
A
D
------
S
I
A
D
G
I
V
R
A
R
Q
V
L
A
D
G
S
A
R
A
C
L
D
A
Y
V
A
F
T
Q
Q
A
T
-
89
HHSearch
83.84
42%
-24
- C7 -
2ELC
4
TRPD_THET8
A:
[2-328]
--
D
A
V
K
K
A
I
L
G
E
V
L
E
E
E
E
A
Y
E
V
M
R
A
L
M
A
G
E
V
S
P
V
R
A
A
G
L
L
V
A
L
S
L
R
G
E
R
P
H
E
I
A
A
M
A
R
A
M
--
R
E
A
A
--
R
P
L
R
V
H
R--
R
P
-
L
L
D
I
V
G
T
G
G
D
G
K
G
L
M
N
L
S
T
L
A
A
L
V
A
A
A
G
G
V
A
V
A
K
H
G
N
R
A
A
S
S
R
A
G
S
A
D
L
L
E
A
L
G
V
D
L
E
A
P
P
E
R
V
G
E
A
I
E
E
L
G
F
G
F
L
F
A
R
V
F
H
P
A
M
R
H
V
A
P
V
R
A
E
L
G
V
R
T
V
F
N
L
L
G
P
L
T
N
P
A
G
A
D
A
Y
V
L
G
V
F
S
P
E
W
L
A
P
M
A
E
A
L
E
R
L
G
A
-
R
G
L
V
V
H
G
-
E
G
A
D
E
L
V
L
-
G
E
N
R
V
V
E
V
G
K
G
---
A
Y
A
L
T
P
E
E
V
G
L
K
R
A
P
L
E
A
L
K
G
G
G
P
E
E
N
A
A
L
A
R
R
L
L
K
G
E
E
---
K
G
P
L
A
D
A
V
A
L
A
A
G
A
G
F
Y
A
A
G
K
-------
T
P
------
S
L
K
E
G
V
A
L
A
R
E
V
L
A
S
G
E
A
Y
L
L
L
E
R
Y
V
A
F
L
R
----
84
HHSearch
81.49
39%
-1
- C7 -
4YI7
1
TRPD_ACIAD
A:
[19-360]
I
Q
Q
A
L
N
H
I
T
K
N
I
H
L
T
Q
A
Q
M
E
D
V
M
R
S
I
M
Q
G
E
A
T
E
A
Q
I
G
A
L
M
M
G
L
R
M
K
G
E
S
I
D
E
I
T
A
A
A
R
V
M
--
R
E
L
A
--
I
K
I
D
V
S
DI-
Q
Y
-
L
V
D
I
V
G
T
G
G
D
--
N
L
F
N
V
S
T
A
S
S
F
V
I
A
A
A
G
A
T
I
A
K
H
G
N
R
-------
S
S
D
L
L
E
Q
A
G
I
N
L
D
L
D
M
Q
Q
T
E
R
C
I
R
E
M
G
V
G
F
L
F
A
------
M
K
Y
A
V
G
P
R
R
E
L
G
I
R
S
I
F
N
L
L
G
P
L
T
N
P
A
G
V
K
R
F
V
I
G
V
F
S
D
E
L
C
R
P
I
A
E
V
M
K
Q
L
G
A
E
H
V
M
V
V
H
S
K
D
G
L
D
E
I
S
L
A
S
Q
T
Y
I
A
E
L
K
N
G
E
V
T
E
W
V
L
N
P
E
D
V
N
I
P
S
Q
T
L
S
G
L
I
V
E
D
S
N
A
S
L
K
L
I
K
D
A
L
G
R
K
K
S
D
I
G
E
K
A
A
N
M
I
A
L
N
A
G
A
G
I
Y
V
S
G
L
-------
A
T
------
S
Y
K
Q
G
V
A
L
A
H
D
I
I
Y
G
G
Q
A
L
E
K
M
S
I
L
S
E
F
T
K
A
L
K
-
39
PsiBlast_CBE
81.36
33%
-30
- C7 -
4N93
5
TRPD_MYCTU
B:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
LS
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
AEWLP-
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
42
PsiBlast_CBE
80.93
33%
-30
- C7 -
3UU1
5
TRPD_MYCTU
C:
[28-369]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
LS
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
---
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
---------EWLP--
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
14
PsiBlast_PDB
80.73
33%
-29
- C7 -
4N5V
7
TRPD_MYCTU
A:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
AE
W
L
P
-
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
66
PsiBlast_CBE
80.71
33%
-27
- C7 -
4OWM
5
TRPD_MYCTU
B:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
--
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAE
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
58
PsiBlast_CBE
80.59
33%
-29
- C7 -
4OWV
3
TRPD_MYCTU
B:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
--
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAE
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
41
PsiBlast_CBE
80.51
33%
-33
- C7 -
4N5V
6
TRPD_MYCTU
B:
[29-372]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
LS
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
AEWLP-
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
L
A
51
PsiBlast_CBE
80.16
33%
-24
- C7 -
3QSA
4
TRPD_MYCTU
B:
[28-369]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
LS
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAEWLP
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
61
PsiBlast_CBE
80.05
33%
-32
- C7 -
4OWS
2
TRPD_MYCTU
A:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
---
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
---
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAE
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
63
PsiBlast_CBE
80.02
33%
-25
- C7 -
4OWO
7
TRPD_MYCTU
B:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAE
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
16
PsiBlast_PDB
80.02
33%
-29
- C7 -
4N93
6
TRPD_MYCTU
A:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
AE
W
L
P
-
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
73
PsiBlast_CBE
80.00
32%
-29
- C7 -
4X5D
2
TRPD_MYCTU
B:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
--
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
A
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAE
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
65
PsiBlast_CBE
79.90
33%
-26
- C7 -
4OWN
9
TRPD_MYCTU
B:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
-
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAE
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
60
PsiBlast_CBE
79.90
33%
-24
- C7 -
4OWU
7
TRPD_MYCTU
A:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAE
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
18
PsiBlast_PDB
79.86
33%
-24
- C7 -
3QQS
4
TRPD_MYCTU
A:
[28-369]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAE
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
67
PsiBlast_CBE
79.82
33%
-24
- C7 -
4OWM
5
TRPD_MYCTU
A:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAE
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
40
PsiBlast_CBE
79.77
33%
-33
- C7 -
4N8Q
1
TRPD_MYCTU
B:
[29-372]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
----
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAE
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
L
A
62
PsiBlast_CBE
79.68
33%
-26
- C7 -
4OWQ
6
TRPD_MYCTU
A:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAE
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
59
PsiBlast_CBE
79.50
33%
-25
- C7 -
4OWU
6
TRPD_MYCTU
B:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
LS
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAEWLP
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
48
PsiBlast_CBE
79.34
33%
-30
- C7 -
3R88
3
TRPD_MYCTU
A:
[28-369]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
-AE
W
L
P
-
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
82
PsiBlast_CBE
79.29
32%
-29
- C7 -
4X59
9
TRPD_MYCTU
B:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
A
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAEW
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
68
PsiBlast_CBE
79.25
33%
-28
- C7 -
4M0R
4
TRPD_MYCTO
A:
[30-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
---
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAE
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
---
87
HHSearch
79.22
33%
-27
- C7 -
4GIU
9
TRPD_MYCTU
A:
[27-369]
W
P
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
--
L
S
H
A
--
H
P
L
P
A
D
TVP
D
D
-
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
----
R
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
LSSRAEW
L
P
------
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
---
47
PsiBlast_CBE
79.15
33%
-31
- C7 -
3R88
4
TRPD_MYCTU
B:
[28-369]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
LS
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
-AEWLP-
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
74
PsiBlast_CBE
79.11
32%
-27
- C7 -
4X5D
3
TRPD_MYCTU
A:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
--
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
A
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAE
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
57
PsiBlast_CBE
79.11
33%
-22
- C7 -
3QQS
4
TRPD_MYCTU
B:
[28-369]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAE
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
83
PsiBlast_CBE
79.10
32%
-28
- C7 -
4X59
3
TRPD_MYCTU
A:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
---
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
A
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAEW
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
49
PsiBlast_CBE
79.06
33%
-25
- C7 -
3R6C
5
TRPD_MYCTU
B:
[28-369]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
LS
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAEWLP
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
50
PsiBlast_CBE
78.92
33%
-23
- C7 -
3R6C
5
TRPD_MYCTU
A:
[28-369]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAEW
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
64
PsiBlast_CBE
78.61
33%
-24
- C7 -
4OWO
7
TRPD_MYCTU
A:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAE
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
70
PsiBlast_CBE
78.57
33%
-24
- C7 -
4GKM
8
TRPD_MYCTU
A:
[30-371]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAEW
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
80
PsiBlast_CBE
78.46
32%
-23
- C7 -
4X5B
3
TRPD_MYCTU
B:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
LS
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
L
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAEWLP
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
72
PsiBlast_CBE
78.46
33%
-23
- C7 -
4GIU
9
TRPD_MYCTU
A:
[29-369]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAEW
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
---
56
PsiBlast_CBE
78.44
33%
-27
- C7 -
3QQS
5
TRPD_MYCTU
C:
[28-367]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
-
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
R
A
E
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
----
15
PsiBlast_PDB
78.44
33%
-24
- C7 -
4N8Q
1
TRPD_MYCTU
A:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
-
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAE
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
20
PsiBlast_PDB
78.43
33%
-26
- C7 -
3QSA
4
TRPD_MYCTU
A:
[28-369]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAE
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
77
PsiBlast_CBE
78.35
32%
-27
- C7 -
4X58
7
TRPD_MYCTU
A:
[37-378]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
A
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAE
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
69
PsiBlast_CBE
78.30
33%
-24
- C7 -
4GKM
10
TRPD_MYCTU
B:
[30-371]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
LS
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAEWLP
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
79
PsiBlast_CBE
77.68
32%
-24
- C7 -
4X5C
3
TRPD_MYCTU
A:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
L
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAE
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
78
PsiBlast_CBE
77.65
32%
-27
- C7 -
4X5C
3
TRPD_MYCTU
B:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
--
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
L
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAE
W
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
34
PsiBlast_CBE
77.64
43%
6
- C7 -
2ELC
2
TRPD_THET8
D:
[21-322]
---------------------
V
M
R
A
L
M
A
G
E
V
S
P
V
R
A
A
G
L
L
V
A
L
S
L
R
G
E
R
P
H
E
I
A
A
M
A
R
A
M
--
R
E
A
A
RP
L
R
V
H
R
R
---
P
--
L
L
D
I
V
G
T
G
G
D
G
K
G
L
M
N
L
S
T
L
A
A
L
V
A
A
A
G
G
V
A
V
A
K
H
G
N
R
A
A
S
S
R
A
G
S
A
D
L
L
E
A
L
G
V
D
L
E
A
P
P
E
R
V
G
E
A
I
E
E
L
G
F
G
F
L
F
A
R
V
F
H
P
A
M
R
H
V
A
P
V
R
A
E
L
G
V
R
T
V
F
N
L
L
G
P
L
T
N
P
A
G
A
D
A
Y
V
L
G
V
F
S
P
E
W
L
A
P
M
A
E
A
L
E
R
L
G
A
R
G
--
L
V
V
H
G
E
G
A
D
E
L
-
V
L
G
E
N
R
V
V
E
V
G
K
G
---
A
Y
A
L
T
P
E
E
V
G
L
K
R
A
P
L
E
A
L
K
G
G
G
P
E
E
N
A
A
L
A
R
R
L
L
K
G
E
E
---
K
G
P
L
A
D
A
V
A
L
A
A
G
A
G
F
Y
A
A
G
K
-------
T
P
------
S
L
K
E
G
V
A
L
A
R
E
V
L
A
S
G
E
A
Y
L
L
L
E
R
----------
81
PsiBlast_CBE
77.20
32%
-21
- C7 -
4X5B
1
TRPD_MYCTU
A:
[29-370]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
L
S
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
L
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAEW
L
P
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
I
--
12
PsiBlast_PDB
75.87
43%
9
- C7 -
2ELC
4
TRPD_THET8
A:
[21-322]
---------------------
V
M
R
A
L
M
A
G
E
V
S
P
V
R
A
A
G
L
L
V
A
L
S
L
R
G
E
R
P
H
E
I
A
A
M
A
R
A
M
--
R
E
A
A
R
P
L
R
V
H
R
R
---
P
--
L
L
D
I
V
G
T
G
G
D
G
K
G
L
M
N
L
S
T
L
A
A
L
V
A
A
A
G
G
V
A
V
A
K
H
G
N
R
A
A
S
S
R
A
G
S
A
D
L
L
E
A
L
G
V
D
L
E
A
P
P
E
R
V
G
E
A
I
E
E
L
G
F
G
F
L
F
A
R
V
F
H
P
A
M
R
H
V
A
P
V
R
A
E
L
G
V
R
T
V
F
N
L
L
G
P
L
T
N
P
A
G
A
D
A
Y
V
L
G
V
F
S
P
E
W
L
A
P
M
A
E
A
L
E
R
L
G
A
R
G
--
L
V
V
H
G
E
G
A
D
E
L
-
V
L
G
E
N
R
V
V
E
V
G
K
G
---
A
Y
A
L
T
P
E
E
V
G
L
K
R
A
P
L
E
A
L
K
G
G
G
P
E
E
N
A
A
L
A
R
R
L
L
K
G
E
E
---
K
G
P
L
A
D
A
V
A
L
A
A
G
A
G
F
Y
A
A
G
K
-------
T
P
------
S
L
K
E
G
V
A
L
A
R
E
V
L
A
S
G
E
A
Y
L
L
L
E
R
----------
35
PsiBlast_CBE
74.94
43%
5
- C7 -
2ELC
3
TRPD_THET8
C:
[21-322]
---------------------
V
M
R
A
L
M
A
G
E
V
S
P
V
R
A
A
G
L
L
V
A
L
S
L
R
G
E
R
P
H
E
I
A
A
M
A
R
A
M
--
R
E
A
A
RP
L
R
V
H
R
R
---
P
--
L
L
D
I
V
G
T
G
G
D
G
K
G
L
M
N
L
S
T
L
A
A
L
V
A
A
A
G
G
V
A
V
A
K
H
G
N
R
A
A
S
S
R
A
G
S
A
D
L
L
E
A
L
G
V
D
L
E
A
P
P
E
R
V
G
E
A
I
E
E
L
G
F
G
F
L
F
A
R
V
F
H
P
A
M
R
H
V
A
P
V
R
A
E
L
G
V
R
T
V
F
N
L
L
G
P
L
T
N
P
A
G
A
D
A
Y
V
L
G
V
F
S
P
E
W
L
A
P
M
A
E
A
L
E
R
L
G
A
R
G
--
L
V
V
H
G
E
G
A
D
E
L
-
V
L
G
E
N
R
V
V
E
V
G
K
G
---
A
Y
A
L
T
P
E
E
V
G
L
K
R
A
P
L
E
A
L
K
G
G
G
P
E
E
N
A
A
L
A
R
R
L
L
K
G
E
E
---
K
G
P
L
A
D
A
V
A
L
A
A
G
A
G
F
Y
A
A
G
K
-------
T
P
------
S
L
K
E
G
V
A
L
A
R
E
V
L
A
S
G
E
A
Y
L
L
L
E
R
----------
71
PsiBlast_CBE
69.12
33%
-23
- C7 -
4GIU
8
TRPD_MYCTU
B:
[29-369]
--
Q
I
L
G
R
L
T
D
N
R
D
L
A
R
G
Q
A
A
W
A
M
D
Q
I
M
T
G
N
A
R
P
A
Q
I
A
A
F
A
V
A
M
T
M
K
A
P
T
A
D
E
V
G
E
L
A
G
V
M
LS
H
A
H
P
--
L
P
A
D
T
V
---
P
D
D
A
V
D
V
V
G
T
G
G
D
G
V
N
T
V
N
L
S
T
M
A
A
I
V
V
A
A
A
G
V
P
V
V
K
H
G
N
R
A
A
S
S
L
S
G
G
A
D
T
L
E
A
L
G
V
R
I
D
L
G
P
D
L
V
A
R
S
L
A
E
V
G
I
G
F
C
F
A
P
R
F
H
P
S
Y
R
H
A
A
A
V
R
R
E
I
G
V
P
T
V
F
N
L
L
G
P
L
T
N
P
A
R
P
R
A
G
L
I
G
C
A
F
A
D
L
A
E
V
M
A
G
V
F
A
A
R
R
-
S
S
V
L
V
V
H
G
D
D
G
L
D
E
L
T
T
T
T
T
S
T
I
W
R
V
A
A
G
S
V
D
K
L
T
F
D
P
A
G
F
G
F
A
R
A
Q
L
D
Q
L
A
G
G
D
A
Q
A
N
A
A
A
V
R
A
V
L
G
G
A
R
---
G
P
V
R
D
A
V
V
L
N
A
A
G
A
I
V
A
H
A
G
L
-------
S
S
RAEWLP
A
W
E
E
G
L
R
R
A
S
A
A
I
D
T
G
A
A
E
Q
L
L
A
R
W
V
R
F
G
R
Q
---