@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22740: (2016-07-05 )
MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDVIERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLEMIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAHRILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADEKIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPALKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARSSLAAIAKYIGKRKF
Atome Classification :
(39 SA)
.........10........20........30........40........50....-.-...-60........70........80--...-..-.--..90.--.....--...100.......110-...--.....120.......130.......140.......150--....-.-----.-..---------160-..-------.......170---......-----...180--.......190.......200.......210...-....220.......230-.........240.......250.......260.......270.-...------.--.--.----280------.---.--....-..--.290..----.......300.......310.......320.......330.......340......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
N
I
I
R
L
L
A
E
SLPRISDGNENT
D
V
W
V
ND
M
K
F
K
M
A
Y
S
F
LND
D
I
D
V
I
E
R
E
L
E
Q
T
V
RS-D-YP
L
-
L
S
E
A
G
L
H
L
L
Q
AGGKR
I
R
P
V
F
V
L
--
L
S
G-MF-G--DYD-I--N
K
I
K
Y
--
V
A
V
T
L
E
M
I
H
M
A
S
L
V
H
--DDV--I
D
D
A
E
LRRGK
P
T
I
K
A
KWD
N
R
I
A
M
Y
TG
D
Y
M
LAG
S
L
E
M
M
---
T
RIN-E-----
P
-
K
A
---------
H
---
R
I
-------
L
S
Q
T
I
V
E
V
-----
C
L
G
E
I
E
-----
Q
I
K
D
K
Y--N
M
E
Q
N
L
R
T
Y
L
R
R
I
K
RK
T
A
L
L
I
A
V
S
C
QLGAIASG-
A
D
E
K
I
H
K
A
L
Y
W
F
G
Y
Y
---VG
M
S
Y
Q
I
I
D
D
I
L
DFTS
T
E
E
E
LGKPVGGDLLQGNV
T
L
P
V
L
Y
A
LK-NP
A
------
L
--
K
--
N
----
Q
--------
L
---
K
--LINS-ET--
T
Q
--
E
Q
----
L
E
P
I
I
E
E
I
K
K
T
D
A
I
E
A
S
M
A
V
S
E
M
Y
L
Q
K
A
F
Q
K
L
N
TLPRGR
A
R
S
S
L
A
A
I
A
K
Y
IGKRKF
22
PsiBlast_CBE
95.37
41%
-98
- C1 -
3AQB
3
HEXB_MICLU
D:
[8-325]
-----------------------------------
A
F
L
N
P
Y
I
I
E
V
E
K
R
L
Y
E
C
I
Q
S
-
D
-
S
E
T
-
I
N
K
A
A
H
H
I
L
S
S
G
G
K
R
V
R
P
M
F
V
L
--
L
S
G
-
F
L
-
N
--
D
T
Q
-
K
--
D
D
L
I
R
--
T
A
V
S
L
E
L
V
H
M
A
S
L
V
H
--
D
D
Y
--
I
D
N
S
D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
H
F
L
L
A
R
A
L
Q
N
I
---
A
T
I
N
-
N
-----
S
-
K
F
---------
H
---
Q
I
-------
F
S
K
T
I
L
E
V
-----
C
F
G
E
F
D
-----
Q
M
A
D
R
F
--
N
Y
P
V
S
F
T
A
Y
L
R
R
I
N
R
K
T
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
Q
-
L
D
E
Q
S
T
Y
H
I
K
Q
F
G
H
C
---
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
T
Y
P
L
M
A
A
I
A
-
N
--------
L
--
K
--
E
----
Q
DDDKLEAV
V
---
K
--
H
L
T
S
-
T
S
--
D
D
--
E
V
----
Y
Q
Y
I
V
S
Q
V
K
Q
Y
-
G
I
E
P
A
E
L
L
S
R
K
Y
G
D
K
A
K
Y
H
L
S
Q
L
Q
D
S
N
I
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
V
Y
21
PsiBlast_CBE
94.24
41%
-100
- C1 -
3AQC
5
HEXB_MICLU
D:
[8-325]
-----------------------------------
A
F
L
N
P
Y
I
I
E
V
E
K
R
L
Y
E
C
I
Q
S
-
D
-
S
E
T
-
I
N
K
A
A
H
H
I
L
S
S
G
G
K
R
V
R
P
M
F
V
L
--
L
S
G
-
F
L
-
N
--
D
T
Q
-
K
--
D
D
L
I
R
--
T
A
V
S
L
E
L
V
H
M
A
S
L
V
H
--
D
D
Y
--
I
D
N
S
D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
H
F
L
L
A
R
A
L
Q
N
I
---
A
T
I
N
-
N
-----
S
-
K
F
---------
H
---
Q
I
-------
F
S
K
T
I
L
E
V
-----
C
F
G
E
F
D
-----
Q
M
A
D
R
F
--
N
Y
P
V
S
F
T
A
Y
L
R
R
I
N
R
K
T
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
Q
-
L
D
E
Q
S
T
Y
H
I
K
Q
F
G
H
C
---
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
T
Y
P
L
M
A
A
I
A
-
N
--------
L
--
K
--
E
----
Q
DDDKLEAV
V
---
K
--
H
L
T
S
-
T
S
--
D
D
--
E
V
----
Y
Q
Y
I
V
S
Q
V
K
Q
Y
-
G
I
E
P
A
E
L
L
S
R
K
Y
G
D
K
A
K
Y
H
L
S
Q
L
Q
D
S
N
I
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
V
Y
1
PsiBlast_PDB
93.89
41%
-93
* C1 *
3AQB
3
HEXB_MICLU
B:
[8-325]
-----------------------------------
A
F
L
N
P
Y
I
I
E
V
E
K
R
L
Y
E
C
I
Q
S
-
D
-
S
E
T
-
I
N
K
A
A
H
H
I
L
S
S
G
G
K
R
V
R
P
M
F
V
L
--
L
S
G
-
F
L
-
N
--
D
T
Q
-
K
--
D
D
L
I
R
--
T
A
V
S
L
E
L
V
H
M
A
S
L
V
H
--
D
D
Y
--
I
D
N
S
D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
H
F
L
L
A
R
A
L
Q
N
I
---
A
T
I
N
-
N
-----
S
-
K
F
---------
H
---
Q
I
-------
F
S
K
T
I
L
E
V
-----
C
F
G
E
F
D
-----
Q
M
A
D
R
F
--
N
Y
P
V
S
F
T
A
Y
L
R
R
I
N
R
K
T
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
Q
-
L
D
E
Q
S
T
Y
H
I
K
Q
F
G
H
C
---
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
T
Y
P
L
M
A
A
I
A
-
N
--------
L
--
K
--
E
----
Q
DDD
K
L
E
A
V
V
---
K
--
H
L
T
S
-
T
S
--
D
D
--
E
V
----
Y
Q
Y
I
V
S
Q
V
K
Q
Y
-
G
I
E
P
A
E
L
L
S
R
K
Y
G
D
K
A
K
Y
H
L
S
Q
L
Q
D
S
N
I
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
V
Y
2
PsiBlast_PDB
93.43
41%
-94
- C1 -
3AQC
5
HEXB_MICLU
B:
[8-325]
-----------------------------------
A
F
L
N
P
Y
I
I
E
V
E
K
R
L
Y
E
C
I
Q
S
-
D
-
S
E
T
-
I
N
K
A
A
H
H
I
L
S
S
G
G
K
R
V
R
P
M
F
V
L
--
L
S
G
-
F
L
-
N
--
D
T
Q
-
K
--
D
D
L
I
R
--
T
A
V
S
L
E
L
V
H
M
A
S
L
V
H
--
D
D
Y
--
I
D
N
S
D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
H
F
L
L
A
R
A
L
Q
N
I
---
A
T
I
N
-
N
-----
S
-
K
F
---------
H
---
Q
I
-------
F
S
K
T
I
L
E
V
-----
C
F
G
E
F
D
-----
Q
M
A
D
R
F
--
N
Y
P
V
S
F
T
A
Y
L
R
R
I
N
R
K
T
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
Q
-
L
D
E
Q
S
T
Y
H
I
K
Q
F
G
H
C
---
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
T
Y
P
L
M
A
A
I
A
-
N
--------
L
--
K
--
E
----
Q
DDD
K
L
E
A
V
V
---
K
--
H
L
T
S
-
T
S
--
D
D
--
E
V
----
Y
Q
Y
I
V
S
Q
V
K
Q
Y
-
G
I
E
P
A
E
L
L
S
R
K
Y
G
D
K
A
K
Y
H
L
S
Q
L
Q
D
S
N
I
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
V
Y
89
Fugue
88.87
41%
-74
- C1 -
3AQB
3
HEXB_MICLU
B:
[5-325]
--------------------------------
S
Y
K
A
F
L
N
P
Y
I
I
E
V
E
K
R
L
Y
E
C
I
Q
S
-
D
-
S
E
T
-
I
N
K
A
A
H
H
I
L
S
S
G
G
K
R
V
R
P
M
F
V
L
--
L
S
G
-
F
L
-
N
--
D
T
Q
-
K
--
D
D
L
I
R
--
T
A
V
S
L
E
L
V
H
M
A
S
L
V
H
--
D
D
Y
--
I
D
N
S
D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
H
F
L
L
A
R
A
L
Q
N
I
---
A
T
I
N
-
N
-----
S
-
K
F
---------
H
---
Q
I
-------
F
S
K
T
I
L
E
V
-----
C
F
G
E
F
D
-----
Q
M
A
D
R
F
--
N
Y
P
V
S
F
T
A
Y
L
R
R
I
N
R
K
T
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
Q
-
L
D
E
Q
S
T
Y
H
I
K
Q
F
G
H
C
---
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
T
Y
P
L
M
A
A
I
A
-
N
L
K
E
Q
DDD
K
L
--
E
--
A
----
V
--------
V
---
K
--
H
L
T
S
--
T
--
S
D
--
D
E
----
V
Y
Q
Y
I
V
S
Q
V
K
Q
Y
G
I
E
P
A
E
L
L
S
R
K
Y
G
D
K
A
K
Y
H
L
S
Q
L
Q
D
S
N
I
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
V
Y
65
HHSearch
86.56
41%
-60
- C1 -
3AQB
3
HEXB_MICLU
B:
[5-324]
--------------------------------
S
Y
K
A
F
L
N
P
Y
I
I
E
V
E
K
R
L
Y
E
C
I
Q
S
-
D
-
S
E
T
-
I
N
K
A
A
H
H
I
L
S
S
G
G
K
R
V
R
P
M
F
V
L
--
L
S
G
-
F
L
N
D
--
T
Q
--
K
--
D
D
L
I
R
--
T
A
V
S
L
E
L
V
H
M
A
S
L
V
H
--
D
D
Y
--
I
D
N
S
D
M
R
R
G
N
T
S
V
H
I
A
F
D
K
D
T
A
I
R
T
G
H
F
L
L
A
R
A
L
Q
N
I
---
A
T
I
N
-
N
-----
S
-
K
F
---------
H
---
Q
I
-------
F
S
K
T
I
L
E
V
-----
C
F
G
E
F
D
-----
Q
M
A
D
R
F
--
N
Y
P
V
S
F
T
A
Y
L
R
R
I
N
R
K
T
A
I
L
I
E
A
S
C
H
L
G
A
L
S
S
Q
-
L
D
E
Q
S
T
Y
H
I
K
Q
F
G
H
C
---
I
G
M
S
Y
Q
I
I
D
D
I
L
D
Y
T
S
D
E
A
T
L
G
K
P
V
G
S
D
I
R
N
G
H
I
T
Y
P
L
M
A
A
I
A
N
L
K
E
------
Q
DD
D
--
K
----
L
E
-------
A
---
V
--
V
K
H
L
T
S
T
S-
D
D
--
E
V
----
Y
Q
Y
I
V
S
Q
V
K
Q
Y
G
-
I
E
P
A
E
L
L
S
R
K
Y
G
D
K
A
K
Y
H
L
S
Q
L
Q
D
S
N
I
K
D
Y
L
E
E
I
H
E
K
M
L
K
R
V
-
4
PsiBlast_PDB
83.04
32%
-113
- C1 -
3WJO
2
?
A:
[36-333]
------------------------------------------------
L
E
Q
-
L
N
S
-
D
-
V
Q
L
-
I
N
Q
L
G
Y
Y
I
V
S
G
G
G
K
R
I
R
P
M
I
A
V
--
L
A
A
-
R
A
-
V
--
G
Y
E
-
G
--
N
A
H
V
T
--
I
A
A
L
I
E
F
I
H
T
A
T
L
L
H
--
D
D
V
--
V
D
E
S
D
M
R
R
G
K
A
T
A
N
A
A
F
G
N
A
A
S
V
L
V
G
D
F
I
Y
T
R
A
F
Q
M
M
---
T
S
L
G
-
S
-----
L
-
K
V
---------
L
---
E
V
-------
M
S
E
A
V
N
V
I
-----
A
E
G
E
V
L
-----
Q
L
M
N
-----------
N
Y
M
R
V
I
Y
S
K
T
A
R
L
F
E
A
A
A
Q
C
S
G
I
L
A
G
-
C
T
P
E
E
E
K
G
L
Q
D
Y
G
R
Y
---
L
G
T
A
F
Q
L
I
D
D
L
L
D
Y
N
A
--------
V
G
D
D
L
N
E
G
K
P
T
L
P
L
L
H
A
M
H
-
H
-
G
------
T
--
P
--
E
----
Q
--------
A
---
Q
--
M
I
R
T
-
A
I
--
E
Q
--
G
N
GRHL
L
E
P
V
L
E
A
M
N
A
C
G
S
L
E
W
T
R
Q
R
A
E
E
E
A
D
K
A
I
A
A
L
Q
V
L
P
D
T
P
W
R
E
A
L
I
G
L
A
H
I
A
V
----
91
Fugue
82.17
27%
-129
- C1 -
3OYR
1
?
A:
[20-343]
--------------------------
K
S
G
S
V
D
R
L
V
R
L
A
E
A
D
M
A
G
V
N
R
L
I
T
D
R
M
Q
S
-
D
-
V
A
I
-
I
P
A
L
A
E
H
L
I
A
A
G
G
K
R
L
R
P
L
M
T
V
--
A
A
A
-
R
L
-
A
--
G
A
D
-
N
--
D
H
F
Q
K
--
L
A
A
A
V
E
F
I
H
T
A
T
L
L
H
--
D
D
V
--
V
V
A
A
---------
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
L
M
---
V
E
T
N
-
S
-----
M
-
K
A
---------
L
---
E
I
-------
L
A
R
A
S
R
V
I
-----
A
E
G
E
V
L
-----
Q
L
M
R
S
H
--
D
L
N
L
S
Q
A
V
Y
L
E
I
I
Q
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
-
V
D
V
A
K
S
E
A
L
R
D
Y
G
L
N
---
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
A
-------------------
T
L
P
L
L
L
A
I
A
-
R
S
G
------
P
--
R
--
E
----
A
--------
E
---
F
--
W
E
R
A
-
I
G
--
T
E
--
A
D
----
F
R
R
A
R
E
L
I
I
G
S
G
A
L
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
M
F
P
A
N
D
W
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
23
PsiBlast_CBE
81.26
32%
-119
- C1 -
3WJN
1
?
B:
[36-335]
------------------------------------------------
L
E
Q
-
L
N
S
-
D
-
V
Q
L
-
I
N
Q
L
G
Y
Y
I
V
S
G
G
G
K
R
I
R
P
M
I
A
V
--
L
A
A
-
R
A
-
V
--
G
Y
E
-
G
--
N
A
H
V
T
--
I
A
A
L
I
E
F
I
H
T
A
T
L
L
H
--
D
D
V
--
V
D
E
S
------------
F
G
N
A
A
S
V
L
V
G
D
F
I
Y
T
R
A
F
Q
M
M
---
T
S
L
G
-
S
-----
L
-
K
V
---------
L
---
E
V
-------
M
S
E
A
V
N
V
I
-----
A
E
G
E
V
L
-----
Q
L
M
N
V
N
--
D
P
D
I
T
E
E
N
Y
M
R
V
I
Y
S
K
T
A
R
L
F
E
A
A
A
Q
C
S
G
I
L
A
G
-
C
T
P
E
E
E
K
G
L
Q
D
Y
G
R
Y
---
L
G
T
A
F
Q
L
I
D
D
L
L
D
Y
N
-------
K
N
V
G
D
D
L
N
E
G
K
P
T
L
P
L
L
H
A
M
H
-
H
-
G
------
T
--
P
--
E
----
Q
--------
A
---
Q
--
M
I
R
T
-
A
I
--
E
Q
--
G
N
GRHL
L
E
P
V
L
E
A
M
N
A
C
G
S
L
E
W
T
R
Q
R
A
E
E
E
A
D
K
A
I
A
A
L
Q
V
L
P
D
T
P
W
R
E
A
L
I
G
L
A
H
I
A
V
Q
R
--
10
PsiBlast_PDB
78.60
29%
-110
- C1 -
3OYR
1
?
A:
[34-343]
----------------------------------------
D
M
A
G
V
N
R
L
I
T
D
R
M
Q
S
-
D
-
V
A
I
-
I
P
A
L
A
E
H
L
I
A
A
G
G
K
R
L
R
P
L
M
T
V
--
A
A
A
-
R
L
-
A
--
G
A
D
-
N
--
D
H
F
Q
K
--
L
A
A
A
V
E
F
I
H
T
A
T
L
L
H
--
D
D
V
--
V
---------
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
L
M
---
V
E
T
N
-
S
-----
M
-
K
A
---------
L
---
E
I
-------
L
A
R
A
S
R
V
I
-----
A
E
G
E
V
L
-----
Q
L
M
R
S
H
--
D
L
N
L
S
Q
A
V
Y
L
E
I
I
Q
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
-
V
D
V
A
K
S
E
A
L
R
D
Y
G
L
N
---
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
-------------------
A
T
L
P
L
L
L
A
I
A
-
R
S
G
------
P
--
R
--
E
A
E
F
W
E
--------
R
---
A
--
I
G
-------
T
E
--
A
D
----
F
R
R
A
R
E
L
I
I
G
S
G
A
L
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
M
F
P
A
N
D
W
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
8
PsiBlast_PDB
75.07
27%
-95
- C1 -
4JYX
4
?
A:
[22-337]
---------------------------
S
M
D
L
D
H
I
L
S
L
A
E
P
D
M
L
A
V
N
Q
L
I
Q
K
Q
V
N
S
-
D
-
V
S
L
-
I
N
Q
L
G
F
Y
I
V
N
S
G
G
K
R
L
R
P
L
L
T
V
--
L
A
A
-
R
A
-
L
--
N
I
Q
-
T
--
E
Q
H
H
T
--
L
A
A
I
I
E
F
I
H
T
A
T
L
L
H
--
D
D
V
--
V
D
E
S
T
M
R
R
G
R
E
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
M
M
---
V
T
L
D
-
S
-----
M
-
R
V
---------
M
---
Q
I
-------
L
S
D
A
T
N
V
I
-----
A
E
G
E
V
L
-----
Q
L
M
N
C
N
--
D
P
D
T
T
E
E
S
Y
M
E
V
I
Y
S
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
-
Q
S
E
A
I
E
N
A
M
Q
D
Y
G
K
Y
---
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
S
-------
N
M
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
-
H
G
N
------
E
--
Q
--
Q
----
T
--------
A
I
I
R
E
--
A
I
E
T
-
G
N
--
G
M
--
D
N
----
L
T
P
I
L
E
T
M
E
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
V
Y
K
E
A
L
I
G
L
A
--------
63
HHSearch
74.92
30%
-65
- C1 -
4LOB
4
?
A:
[30-346]
--------------------------------
D
I
L
A
P
V
A
T
D
F
A
A
M
D
H
L
I
N
E
G
I
S
S
-
K
-
V
G
L
-
V
M
S
V
S
K
H
V
V
E
A
G
G
K
R
M
R
P
I
M
C
L
--
L
A
A
-
R
A
C
D
--
L
D
N
-
M
--
Q
N
A
Q
R
--
L
A
A
I
I
E
M
L
H
T
A
T
L
V
H
--
D
D
V
--
V
D
--------------
W
N
N
Q
T
A
V
L
V
G
D
F
L
I
A
R
A
F
D
L
L
---
V
D
L
N
-
N
-----
M
-
T
L
---------
L
---
K
D
-------
F
S
T
G
T
C
E
I
-----
A
E
G
E
V
L
-----
Q
L
Q
S
Q
H
--
Q
P
D
T
T
E
E
T
Y
L
K
I
I
H
G
K
T
S
R
L
F
E
L
A
T
E
G
A
A
I
L
A
G
-
Q
E
-
A
Y
R
E
P
L
R
L
F
A
G
H
---
F
G
N
A
F
Q
I
I
D
D
I
L
D
Y
T
S
D
A
E
T
L
G
K
N
I
G
D
D
L
M
E
G
K
P
T
L
P
L
I
S
A
L
A
H
S
T
G
------
E
--
E
H
A
I
----
I
R
-------
R
---
S
--
I
A
T
---
G
--
G
V
--
D
Q
----
L
P
K
V
I
E
I
V
Q
K
S
G
A
L
D
Y
C
Q
R
R
A
Q
E
E
T
E
A
A
L
Q
A
L
S
I
L
P
D
T
P
Y
R
Q
A
L
I
N
L
T
R
L
A
L
H
R
I
-
3
PsiBlast_PDB
72.79
32%
-65
- C1 -
4LOB
3
?
A:
[38-335]
----------------------------------------
D
F
A
A
M
D
H
L
I
N
E
G
I
S
S
-
K
-
V
G
L
-
V
M
S
V
S
K
H
V
V
E
A
G
G
K
R
M
R
P
I
M
C
L
--
L
A
A
-
R
A
-
C
--
D
L
D
N
M
--
Q
N
A
Q
R
--
L
A
A
I
I
E
M
L
H
T
A
T
L
V
H
--
D
D
V
--
V
D
--------------
W
N
N
Q
T
A
V
L
V
G
D
F
L
I
A
R
A
F
D
L
L
---
V
D
L
N
-
N
-----
M
-
T
L
---------
L
---
K
D
-------
F
S
T
G
T
C
E
I
-----
A
E
G
E
V
L
-----
Q
L
Q
S
Q
H
--
Q
P
D
T
T
E
E
T
Y
L
K
I
I
H
G
K
T
S
R
L
F
E
L
A
T
E
G
A
A
I
L
A
G
--
Q
E
A
Y
R
E
P
L
R
L
F
A
G
H
---
F
G
N
A
F
Q
I
I
D
D
I
L
D
Y
T
S
D
A
E
T
L
G
K
N
I
G
D
D
L
M
E
G
K
P
T
L
P
L
I
S
A
L
A
-
H
S
T
------
G
--
E
--
E
----
H
--------
A
---
I
--
I
R
R
S
-
I
A
--
T
G
GV
D
Q
----
L
P
K
V
I
E
I
V
Q
K
S
G
A
L
D
Y
C
Q
R
R
A
Q
E
E
T
E
A
A
L
Q
A
L
S
I
L
P
D
T
P
Y
R
Q
A
L
------------
67
HHSearch
72.10
28%
-54
- C1 -
3PKO
2
?
A:
[14-333]
------------------------------
L
W
R
Q
F
P
Q
V
E
P
Q
L
T
A
L
Q
D
Y
L
L
R
T
V
Q
L
-
D
-
N
Q
P
-
I
H
H
K
I
L
A
L
L
K
S
G
G
K
L
L
R
P
G
Y
F
Y
--
L
F
S
-
T
F
G
N
--
A
A
T
-
P
--
A
Q
L
Q
A
--
G
A
A
A
I
E
I
L
H
V
G
T
L
I
H
--
D
D
V
--
I
D
D
S
P
T
R
R
G
V
R
T
I
Q
M
T
Y
G
Q
R
N
A
I
Y
A
G
D
F
M
F
T
V
Y
F
D
Q
V
---
L
K
S
T
T
D
-----
R
-
S
L
---------
I
---
Q
N
-------
H
I
D
A
M
H
R
I
-----
L
Q
G
E
L
H
-----
Q
M
D
L
N
Y
--
R
E
D
I
T
L
D
A
Y
L
N
E
I
A
G
K
T
A
E
L
F
A
L
S
C
Y
Q
G
A
Q
L
A
G
-
A
P
Q
S
V
I
D
R
T
R
D
I
G
I
A
---
I
G
C
A
Y
Q
M
L
D
D
I
L
D
Y
A
G
D
P
K
R
T
Q
K
P
V
L
E
D
L
R
S
G
V
Y
S
L
P
L
L
L
S
L
S
H
A
P
R
------
D
--
F
--
H
-------------
K
---
L
--
L
K
K
K
Q
A
M
--
T
L
--
E
D
----
I
K
H
V
Q
A
L
V
A
Q
Y
D
G
V
G
A
A
K
Q
L
A
Q
D
Y
T
D
R
A
L
T
L
I
Q
Q
L
P
V
G
S
A
Q
Q
S
L
E
Q
L
T
R
L
L
L
R
R
D
-
9
PsiBlast_PDB
71.85
27%
-94
- C1 -
4JXY
2
?
A:
[16-337]
-------------------
E
N
--
L
Y
F
Q
S
M
D
L
D
H
I
L
S
L
A
E
P
D
M
L
A
V
N
Q
L
I
Q
K
Q
V
N
S
-
D
-
V
S
L
-
I
N
Q
L
G
F
Y
I
V
N
S
G
G
K
R
L
R
P
L
L
T
V
--
L
A
A
-
R
A
-
L
--
N
I
Q
-
T
--
E
Q
H
H
T
--
L
A
A
I
I
E
F
I
H
T
A
T
L
L
H
--
D
D
V
--
V
D
---------
T
A
N
E
V
F
G
N
Q
A
S
V
L
V
G
D
F
L
Y
T
R
S
F
Q
M
M
---
V
T
L
D
-
S
-----
M
-
R
V
---------
M
---
Q
I
-------
L
S
D
A
T
N
V
I
-----
A
E
G
E
V
L
-----
Q
L
M
N
C
N
--
D
P
D
T
T
E
E
S
Y
M
E
V
I
Y
S
K
T
A
R
L
F
E
A
A
T
L
L
A
G
V
L
T
K
-
Q
S
E
A
I
E
N
A
M
Q
D
Y
G
K
Y
---
L
G
T
A
F
Q
L
V
D
D
I
M
D
Y
A
----------
G
D
D
L
A
E
G
K
P
T
L
P
L
L
Y
A
M
W
-
H
G
N
------
E
--
Q
--
Q
----
T
--------
A
I
I
R
E
--
A
I
E
T
-
G
N
--
G
M
--
D
N
----
L
T
P
I
L
E
T
M
E
Q
T
G
A
L
T
Y
T
K
Q
Q
A
L
K
A
S
Q
Q
A
I
D
A
L
S
P
I
E
E
S
V
Y
K
E
A
L
I
G
L
A
--------
62
HHSearch
70.82
28%
-73
- C1 -
3OYR
1
?
A:
[20-343]
--------------------------
K
S
G
S
V
D
R
L
V
R
L
A
E
A
D
M
A
G
V
N
R
L
I
T
D
R
M
Q
S
-
D
-
V
A
I
-
I
P
A
L
A
E
H
L
I
A
A
G
G
K
R
L
R
P
L
M
T
V
--
A
A
A
-
R
L
A
G
--
A
D
--
N
--
D
H
F
Q
K
--
L
A
A
A
V
E
F
I
H
T
A
T
L
L
H
--
D
D
V
--
V
---------
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
L
M
---
V
E
T
N
-
S
-----
M
-
K
A
---------
L
---
E
I
-------
L
A
R
A
S
R
V
I
-----
A
E
G
E
V
L
-----
Q
L
M
R
S
H
--
D
L
N
L
S
Q
A
V
Y
L
E
I
I
Q
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
-
V
D
V
A
K
S
E
A
L
R
D
Y
G
L
N
---
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
-------------------
A
T
L
P
L
L
L
A
I
A
R
S
G
P
R-----
E
--
A
E
-
F
----
W
E
-------
R
---
A
--
I
G
-------
T
E
--
A
D
----
F
R
R
A
R
E
L
I
I
G
S
G
A
L
D
A
T
L
D
L
A
A
D
Y
A
D
K
A
K
A
A
L
A
M
F
P
A
N
D
W
R
E
A
L
E
E
L
A
D
F
A
V
S
R
--
6
PsiBlast_PDB
70.52
34%
-13
- C1 -
3Q2Q
5
?
A:
[40-350]
-------------------------------------
I
N
D
A
M
V
Q
V
E
E
L
L
H
T
E
L
S
S
-
G
-
E
D
F
-
L
V
D
I
V
M
H
L
T
R
A
G
G
K
R
F
R
P
M
F
A
L
--
L
A
S
-
E
F
-
G
--
E
K
P
-
L
S
E
N
V
I
K
---
A
A
V
V
V
E
I
T
H
L
A
T
L
Y
H
--
D
D
V
--
M
D
E
A
-------
S
A
N
A
R
W
D
N
S
V
A
I
L
A
G
D
I
L
L
A
H
A
S
G
L
M
---
S
Q
L
G
T
D
-----
T
-
V
A
---------
H
------------
F
A
E
T
F
G
E
L
-----
V
T
G
Q
M
R
-----
E
T
V
G
P
R
--
D
T
D
P
-
I
E
H
Y
T
N
V
I
R
E
K
T
G
V
L
I
A
S
A
G
Y
L
G
A
M
H
A
G
-
A
A
P
E
H
I
D
A
L
K
N
F
G
A
A
---
V
G
M
I
F
Q
I
V
D
D
I
I
D
I
F
S
E
T
H
----
T
P
G
T
D
L
R
E
G
V
F
T
L
P
V
L
Y
A
L
R
E
D
T
P
------
V
--
G
--
A
----
E
--------
L
---
R
D
I
L
T
G
P
-
L
E
--
D
D
--
E
T
----
V
N
H
V
L
E
L
L
S
Q
S
G
G
R
Q
A
A
L
D
E
V
Y
R
Y
M
D
I
A
N
A
E
L
D
R
L
P
D
S
T
V
K
E
A
L
R
N
L
A
T
F
T
V
K
R
--
69
HHSearch
69.38
30%
-3
- C1 -
1WY0
2
?
A:
[2-341]
----------------------------
E
K
Y
E
E
L
F
A
R
I
K
E
K
A
K
L
I
D
E
K
I
F
E
L
I
P
E
-
K
D
P
R
V
-
L
Y
E
A
A
R
H
Y
P
L
A
G
G
K
R
V
R
P
F
V
V
L
--
T
S
T
-
E
A
V
G
--
G
D
--
P
--
L
R
A
I
Y
--
P
A
V
A
I
E
L
I
H
N
Y
S
L
V
H
--
D
D
I
--
M
D
M
D
E
T
R
R
G
K
P
T
V
H
R
I
W
G
V
N
M
A
I
L
A
G
D
L
L
F
S
K
A
F
E
A
V
---
A
R
A
E
-
I
P
P
E
K
K
A
-
R
V
---------
L
---
E
V
-------
I
V
K
A
S
N
E
L
-----
C
E
G
Q
A
R
-----
D
L
E
F
E
K
--
K
S
T
V
T
I
E
E
Y
M
E
M
I
S
G
K
T
G
A
L
F
E
A
S
A
K
V
G
G
I
I
G
T
-
D
N
E
E
Y
I
K
A
L
S
S
W
G
R
N
---
V
G
I
A
F
Q
I
W
D
D
V
L
D
L
I
A
D
E
K
K
L
G
K
P
V
G
S
D
I
R
K
G
K
K
T
L
I
V
A
H
F
F
E
N
A
D
E
------
K
D
K
Q
--
R
----
F
L
-------
K
---
I
--
F
G
K
---
D
--
I
K
--
S
D
----
V
M
E
A
I
D
L
L
K
K
Y
G
S
I
D
Y
A
A
E
I
A
K
D
M
I
K
K
A
N
E
A
L
R
I
L
P
K
S
K
A
R
M
D
L
E
L
L
A
K
F
I
V
E
R
E
-
84
HHSearch
68.71
29%
-41
- C1 -
3IPI
6
GFPS_METMA
A:
[8-283]
--------------------------------------
W
E
E
Y
R
Y
V
E
A
G
I
K
E
S
I
T
L
I
E
-
D
P
G
-
L
K
K
M
V
E
H
V
C
H
S
G
G
K
R
I
R
P
I
I
L
L
--
L
V
S
-
E
I
C
S
--
G
S
--
Y
--
S
R
S
L
N
--
A
A
L
A
V
E
M
M
H
S
A
S
L
I
H
--
D
D
L
--
L
D
Q
G
L
V
R
R
N
L
P
S
A
P
E
K
F
G
P
S
G
A
L
L
C
G
D
Y
L
I
A
K
S
I
A
F
I
---
S
P
Y
G
-------
E
-
K
V
---------
I
---
Q
D
-------
F
G
K
A
G
M
D
M
-----
A
E
G
E
V
L
-----
D
L
K
----------
E
N
D
Y
F
K
C
I
Y
K
K
T
A
S
L
F
A
I
S
A
S
I
G
A
Y
T
G
G
-
A
E
E
E
L
A
E
R
F
S
H
F
G
N
A
---
L
G
T
A
Y
Q
I
V
D
D
I
L
E
F
L
E
V
V
--
E
G
-----------
E
T
L
P
H
I
Y
M
K
S
T
S
K
E
---------------------------------------------------------------
E
A
L
K
K
S
I
D
C
V
K
L
H
V
A
A
A
K
E
T
L
E
T
F
R
E
C
P
A
R
D
K
L
F
Q
I
T
D
Y
I
T
V
D
M
-
5
PsiBlast_PDB
68.55
34%
-21
- C- -
3LMD
-
?
A:
[38-348]
-------------------------------------
I
N
D
A
M
V
Q
V
E
E
L
L
H
T
E
L
S
S
-
G
-
E
D
F
-
L
V
D
I
V
M
H
L
T
R
A
G
G
K
R
F
R
P
M
F
A
L
--
L
A
S
-
E
F
-
G
--
E
K
P
-
L
S
E
N
V
I
K
---
A
A
V
V
V
E
I
T
H
L
A
T
L
Y
H
--
D
D
V
--
M
D
-----------
N
A
R
W
D
N
S
V
A
I
L
A
G
D
I
L
L
A
H
A
S
G
L
M
---
S
Q
L
G
T
D
-----
T
-
V
A
---------
H
------------
F
A
E
T
F
G
E
L
-----
V
T
G
Q
M
R
-----
E
T
V
G
P
R
--
D
T
D
P
-
I
E
H
Y
T
N
V
I
R
E
K
T
G
V
L
I
A
S
A
G
Y
L
G
A
M
H
A
G
-
A
A
P
E
H
I
D
A
L
K
N
F
G
A
A
---
V
G
M
I
F
Q
I
V
D
D
I
I
D
I
F
S
--------
P
G
T
D
L
R
E
G
V
F
T
L
P
V
L
Y
A
L
R
E
D
T
P
------
V
--
G
--
A
----
E
--------
L
---
R
D
I
L
T
G
P
-
L
E
--
D
D
--
E
T
----
V
N
H
V
L
E
L
L
S
Q
S
G
G
R
Q
A
A
L
D
E
V
Y
R
Y
M
D
I
A
N
A
E
L
D
R
L
P
D
S
T
V
K
E
A
L
R
N
L
A
T
F
T
V
K
R
--
13
PsiBlast_PDB
65.61
30%
-25
- C1 -
3PKO
2
?
A:
[32-332]
------------------------------------------------
L
L
R
T
V
Q
L
-
D
-
N
Q
P
-
I
H
H
K
I
L
A
L
L
K
S
G
G
K
L
L
R
P
G
Y
F
Y
--
L
F
S
-
T
F
-
G
--
N
A
A
-
T
P
-
A
Q
L
Q
A
--
G
A
A
A
I
E
I
L
H
V
G
T
L
I
H
--
D
D
V
--
I
D
D
S
P
T
R
R
G
V
R
T
I
Q
M
T
Y
G
Q
R
N
A
I
Y
A
G
D
F
M
F
T
V
Y
F
D
Q
V
---
L
K
S
T
-
T
-----
D
-
R
S
L
I
Q
N
H
I
D
A
M
H
---
R
I
-------
L
Q
-------------
G
E
L
H
-----
Q
M
D
L
N
Y
--
R
E
D
I
T
L
D
A
Y
L
N
E
I
A
G
K
T
A
E
L
F
A
L
S
C
Y
Q
G
A
Q
L
A
G
-
A
P
Q
S
V
I
D
R
T
R
D
I
G
I
A
---
I
G
C
A
Y
Q
M
L
D
D
I
L
D
Y
A
G
D
P
K
R
T
Q
K
P
V
L
E
D
L
R
S
G
-
V
Y
S
L
P
L
L
L
S
L
-
S
H
A
------
P
--
R
--
D
----
F
--------
H
---
K
--
L
L
K
K
-
K
Q
AM
T
L
--
E
D
----
I
K
H
V
Q
A
L
V
A
Q
Y
D
G
V
G
A
A
K
Q
L
A
Q
D
Y
T
D
R
A
L
T
L
I
Q
Q
L
P
V
G
S
A
Q
Q
S
L
E
Q
L
T
R
L
L
L
R
R
--
36
PsiBlast_CBE
51.37
35%
-19
- C1 -
3Q1O
4
?
A:
[36-256]
----------------------------------------------------
L
E
S
-
F
-
H
P
Y
-
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
-
L
V
-
G
Q
K
D
Y
S
-
N
--
Q
Q
T
E
Y
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
--
D
D
L
PC
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
---
S
N
A
--
L
-----
L
-
E
S
---------
H
---
I
I
-------
V
E
L
I
K
I
L
S
-----
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
C
Y
F
E
N
T
P
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
I
K
D
E
E
L
F
K
W
L
Q
A
F
G
L
K
---
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
-------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
51.31
35%
-21
- C1 -
3Q1O
5
?
C:
[36-256]
----------------------------------------------------
L
E
S
-
F
-
H
P
Y
-
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
AV
L
C
A
-
L
V
-
G
QK
D
Y
S
-
N
--
Q
Q
T
E
Y
FK
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
--
D
D
L
PC
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
---
S
N
A
--
L
-----
L
-
E
S
---------
H
---
I
I
-------
V
E
L
I
K
I
L
S
-----
A
N
G
G
I
K
GMILG
Q
A
L
D
C
Y
FE
N
T
P
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
I
K
D
E
E
L
F
K
W
L
Q
A
F
G
L
K
---
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
-------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
51.12
35%
-21
- C1 -
3Q1O
3
?
D:
[36-256]
----------------------------------------------------
L
E
S
-
F
-
H
P
Y
-
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
AV
L
C
A
-
L
V
-
G
QK
D
Y
S
-
N
--
Q
Q
T
E
Y
FK
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
--
D
D
L
PC
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
---
S
N
A
--
L
-----
L
-
E
S
---------
H
---
I
I
-------
V
E
L
I
K
I
L
S
-----
A
N
G
G
I
K
GMILG
Q
A
L
D
C
Y
FE
N
T
P
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
I
K
D
E
E
L
F
K
W
L
Q
A
F
G
L
K
---
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
-------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
50.75
35%
-19
- C1 -
3Q1O
3
?
B:
[36-256]
----------------------------------------------------
L
E
S
-
F
-
H
P
Y
-
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
-
L
V
-
G
Q
K
D
Y
S
-
N
--
Q
Q
T
E
Y
F
K
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
--
D
D
L
PC
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
---
S
N
A
--
L
-----
L
-
E
S
---------
H
---
I
I
-------
V
E
L
I
K
I
L
S
-----
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
C
Y
F
E
N
T
P
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
I
K
D
E
E
L
F
K
W
L
Q
A
F
G
L
K
---
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
-------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
48.76
32%
-2
- C1 -
3KRF
4
?
A:
[15-272]
--------------------------------------------
V
N
K
A
L
E
A
A
V
Q
M
-
K
-
E
P
L
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
-
E
L
-
V
--
G
G
D
-
E
--
S
T
A
M
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
--
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
T
K
G
A
-
P
-----
P
E
R
I
---------
V
---
R
V
-------
L
G
E
L
A
V
S
I
GSEG
L
V
A
G
Q
V
V
-----
D
V
C
S
E
G
--
M
A
E
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
-
G
K
E
E
E
V
A
K
L
R
K
F
A
N
C
---
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
-
K
S
----------
K
--
E
----
F
--------
A
---
D
--
R
L
N
R
-
E
---
A
Q
--
E
Q
----
L
-------------------------------------------------------
25
PsiBlast_CBE
48.44
32%
16
- C1 -
3OAC
4
?
D:
[15-272]
--------------------------------------------
V
N
K
A
L
E
A
A
V
Q
M
-
K
-
E
P
L
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
-
E
L
-
V
--
G
G
D
-
E
--
S
T
A
M
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
--
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
AAA
T
K
G
A
-
P
-----
P
E
R
I
---------
V
---
R
V
-------
L
G
E
L
A
V
S
I
GSEGL
V
A
G
Q
V
V
-----
D
V
C
S
E
G
--
M
A
E
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
-
G
K
E
E
E
V
A
K
L
R
K
F
A
N
C
---
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
-
K
S
----------
K
--
E
----
F
--------
A
---
D
--
R
L
N
R
-
E
---
A
Q
--
E
Q
----
L
-------------------------------------------------------
20
PsiBlast_PDB
48.17
32%
1
- C1 -
3KRP
3
?
A:
[15-272]
--------------------------------------------
V
N
K
A
L
E
A
A
V
Q
M
-
K
-
E
P
L
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
-
E
L
-
V
--
G
G
D
-
E
--
S
T
A
M
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
--
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
T
K
G
A
-
P
-----
P
E
R
I
---------
V
---
R
V
-------
L
G
E
L
A
V
S
I
GSEG
L
V
A
G
Q
V
V
-----
D
V
C
S
E
G
--
M
A
E
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
-
G
K
E
E
E
V
A
K
L
R
K
F
A
N
C
---
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
-
K
S
----------
K
--
E
----
F
--------
A
---
D
--
R
L
N
R
-
E
---
A
Q
--
E
Q
----
L
-------------------------------------------------------
31
PsiBlast_CBE
47.75
32%
-8
- C1 -
3KRC
1
?
D:
[15-272]
--------------------------------------------
V
N
K
A
L
E
A
A
V
Q
M
-
K
-
E
P
L
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
-
E
L
-
V
--
G
G
D
-
E
--
S
T
A
M
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
--
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
AAA
T
K
G
A
-
P
-----
P
E
R
I
---------
V
---
R
V
-------
L
G
E
L
A
V
S
I
GSEGL
V
A
G
Q
V
V
-----
D
V
C
S
E
G
--
M
A
E
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
-
G
K
E
E
E
V
A
K
L
R
K
F
A
N
C
---
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
------------------
T
T
Y
P
K
L
I
G
V
E
-
K
S
----------
K
--
E
----
F
--------
A
---
D
--
R
L
N
R
-
E
---
A
Q
--
E
Q
----
L
-------------------------------------------------------
27
PsiBlast_CBE
47.75
32%
-2
- C1 -
3OAB
4
?
A:
[15-272]
--------------------------------------------
V
N
K
A
L
E
A
A
V
Q
M
-
K
-
E
P
L
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
-
E
L
-
V
--
G
G
D
-
E
--
S
T
A
M
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
--
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
AA
T
K
G
A
-
P
-----
P
E
R
I
---------
V
---
R
V
-------
L
G
E
L
A
V
S
I
GSEG
L
V
A
G
Q
V
V
-----
D
V
C
S
E
G
--
M
A
E
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
-
G
K
E
E
E
V
A
K
L
R
K
F
A
N
C
---
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
-
K
S
----------
K
--
E
----
F
--------
A
---
D
--
R
L
N
R
-
E
---
A
Q
--
E
Q
----
L
-------------------------------------------------------
19
PsiBlast_PDB
47.39
32%
1
- C1 -
3KRO
4
?
A:
[15-272]
--------------------------------------------
V
N
K
A
L
E
A
A
V
Q
M
-
K
-
E
P
L
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
-
E
L
-
V
--
G
G
D
-
E
--
S
T
A
M
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
--
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
T
K
G
A
-
P
-----
P
E
R
I
---------
V
---
R
V
-------
L
G
E
L
A
V
S
I
GSEG
L
V
A
G
Q
V
V
-----
D
V
C
S
E
G
--
M
A
E
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
-
G
K
E
E
E
V
A
K
L
R
K
F
A
N
C
---
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
T
T
Y
P
K
L
I
G
V
E
-
K
S
----------
K
--
E
----
F
--------
A
---
D
--
R
L
N
R
-
E
---
A
Q
--
E
Q
----
L
-------------------------------------------------------
26
PsiBlast_CBE
47.11
32%
22
- C1 -
3OAB
4
?
D:
[15-272]
--------------------------------------------
V
N
K
A
L
E
A
A
V
Q
M
-
K
-
E
P
L
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
-
E
L
-
V
--
G
G
D
-
E
--
S
T
A
M
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
--
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
AAA
T
K
G
A
-
P
-----
P
E
R
I
---------
V
---
R
V
-------
L
G
E
L
A
V
S
I
GSEGL
V
A
G
Q
V
V
-----
D
V
C
S
E
G
--
M
A
E
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
-
G
K
E
E
E
V
A
K
L
R
K
F
A
N
C
---
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
-
K
S
----------
K
--
E
----
F
--------
A
---
D
--
R
L
N
R
-
E
---
A
Q
--
E
Q
----
L
-------------------------------------------------------
52
PsiBlast_CBE
46.96
31%
8
- C1 -
1RQI
6
ISPA_ECOLI
A:
[44-290]
-------------------------------------------------------------------------
G
G
K
R
L
R
P
F
L
V
Y
--
A
T
G
H
M
F
-
G
---
V
S
-
T
--
N
T
L
D
A
--
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
--
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
---
S
D
A
D
-
M
-----
P
-
E
V
---------
S
D
R
D
R
I
S
M
I
S
E
L
A
S
A
S
G
I
A
G
M
-----
C
G
G
Q
A
L
-----
D
L
-
D
A
E
--
G
K
H
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
G
---
D
K
G
R
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
-
Q
-
A
------
R
--
K
--
K
----
A
--------
R
---
D
--
L
I
D
D
-----
A
R
--
Q
S
----
L
K
Q
L
A
E
Q
S
L
D
T
S
A
L
E
A
----------------------------------------
30
PsiBlast_CBE
46.88
32%
16
- C1 -
3KRF
4
?
D:
[15-272]
--------------------------------------------
V
N
K
A
L
E
A
A
V
Q
M
-
K
-
E
P
L
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
-
E
L
-
V
--
G
G
D
-
E
--
S
T
A
M
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
--
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
AAA
T
K
G
A
-
P
-----
P
E
R
I
---------
V
---
R
V
-------
L
G
E
L
A
V
S
I
GSEGL
V
A
G
Q
V
V
-----
D
V
C
S
E
G
--
M
A
E
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
-
G
K
E
E
E
V
A
K
L
R
K
F
A
N
C
---
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
-
K
S
----------
K
--
E
----
F
--------
A
---
D
--
R
L
N
R
-
E
---
A
Q
--
E
Q
----
L
-------------------------------------------------------
29
PsiBlast_CBE
46.50
32%
19
- C1 -
3KRO
4
?
D:
[15-272]
--------------------------------------------
V
N
K
A
L
E
A
A
V
Q
M
-
K
-
E
P
L
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
-
E
L
-
V
--
G
G
D
-
E
--
S
T
A
M
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
--
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
AAA
T
K
G
A
-
P
-----
P
E
R
I
---------
V
---
R
V
-------
L
G
E
L
A
V
S
I
GSEGL
V
A
G
Q
V
V
-----
D
V
C
S
E
G
--
M
A
E
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
-
G
K
E
E
E
V
A
K
L
R
K
F
A
N
C
---
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
-
K
S
----------
K
--
E
----
F
--------
A
---
D
--
R
L
N
R
-
E
---
A
Q
--
E
Q
----
L
-------------------------------------------------------
51
PsiBlast_CBE
46.40
31%
5
- C1 -
1RQI
5
ISPA_ECOLI
B:
[44-290]
-------------------------------------------------------------------------
G
G
K
R
L
R
P
F
L
V
Y
--
A
T
G
H
M
F
-
G
---
V
S
-
T
--
N
T
L
D
A
--
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
--
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
---
S
D
A
D
-
M
-----
P
-
E
V
---------
S
D
R
D
R
I
S
M
I
S
E
L
A
S
A
S
G
I
A
G
M
-----
C
G
G
Q
A
L
-----
D
L
-
D
A
E
--
G
K
H
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
G
---
D
K
G
R
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
-
Q
-
A
------
R
--
K
--
K
----
A
--------
R
---
D
--
L
I
D
D
-----
A
R
--
Q
S
----
L
K
Q
L
A
E
Q
S
L
D
T
S
A
L
E
A
----------------------------------------
53
PsiBlast_CBE
45.46
31%
9
- C1 -
1RQJ
5
ISPA_ECOLI
B:
[43-289]
-------------------------------------------------------------------------
G
G
K
R
L
R
P
F
L
V
Y
--
A
T
G
H
M
F
-
G
---
V
S
-
T
--
N
T
L
D
A
--
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
--
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
---
S
D
A
D
-
M
-----
P
-
E
V
---------
S
D
R
D
R
I
S
M
I
S
E
L
A
S
A
S
G
I
A
G
M
-----
C
G
G
Q
A
L
-----
D
L
-
D
A
E
--
G
K
H
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
G
---
D
K
G
R
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
-
Q
-
A
------
R
--
K
--
K
----
A
--------
R
---
D
--
L
I
D
D
-----
A
R
--
Q
S
----
L
K
Q
L
A
E
Q
S
L
D
T
S
A
L
E
A
----------------------------------------
54
PsiBlast_CBE
45.12
31%
12
- C1 -
1RQJ
5
ISPA_ECOLI
A:
[43-289]
-------------------------------------------------------------------------
G
G
K
R
L
R
P
F
L
V
Y
--
A
T
G
H
M
F
-
G
---
V
S
-
T
--
N
T
L
D
A
--
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
--
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
---
S
D
A
D
-
M
-----
P
-
E
V
---------
S
D
R
D
R
I
S
M
I
S
E
L
A
S
A
S
G
I
A
G
M
-----
C
G
G
Q
A
L
-----
D
L
-
D
A
E
--
G
K
H
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
V
R
L
G
A
L
S
A
G
---
D
K
G
R
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
-
Q
-
A
------
R
--
K
--
K
----
A
--------
R
---
D
--
L
I
D
D
-----
A
R
--
Q
S
----
L
K
Q
L
A
E
Q
S
L
D
T
S
A
L
E
A
----------------------------------------
28
PsiBlast_CBE
44.45
32%
16
- C1 -
3KRP
3
?
D:
[15-272]
--------------------------------------------
V
N
K
A
L
E
A
A
V
Q
M
-
K
-
E
P
L
K
I
H
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
--
A
A
C
-
E
L
-
V
--
G
G
D
-
E
--
S
T
A
M
P
--
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
--
D
D
L
PC
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
AAA
T
K
G
A
-
P
-----
P
E
R
I
---------
V
---
R
V
-------
L
G
E
L
A
V
S
I
GSEGL
V
A
G
Q
V
V
-----
D
V
C
S
E
G
--
M
A
E
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
V
V
L
G
A
I
L
G
G
-
G
K
E
E
E
V
A
K
L
R
K
F
A
N
C
---
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
-----------
T
Y
P
K
L
I
G
V
E
-
K
S
----------
K
--
E
----
F
--------
A
---
D
--
R
L
N
R
-
E
---
A
Q
--
E
Q
----
L
-------------------------------------------------------