@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22870: (2016-07-05 )
MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVDISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPSERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGDRSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSKIENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASCTGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHHWLTERGVNTSSYSVR
Atome Classification :
(21 SA)
.........10....---....20........30........40........50........60.....-...70........80........90........100.......110.......120.......130---....----.....140.......150.......160..-.....170.......180.......190.......200.......210.......220.......230-----.........240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
R
A
E
R
K
R
Q
H
I
N
H
A
L
---SIGQKRETGLD
D
I
T
F
V
H
VSLP
D
L
A
L
E
QVDISTKIGELSSSS
P
I
F
I
N
A
MTGG-G
G
K
L
T
Y
E
I
N
K
S
L
A
R
A
A
S
QAGI
P
L
AVGS
Q
M
S
ALK
D
P
S
E
R
L
S
Y
E
I
V
RKENPN
G
L
I
F
A
NLGSE
A
T
A
A
-----
Q
A
K
E
----
A
V
E
M
IGA
N
A
L
Q
I
H
L
N
V
I
Q
E
I
VMPEGD
R
S
F
S
-
G
A
L
K
R
I
E
Q
I
C
S
RVSV
P
V
I
V
K
E
VGFGMSKASAGKLYEAGA
A
A
V
D
IGGYGGT
N
F
S
K
I
E
N
L
R
R
Q
R
Q
I
S
F
-------
F
NSWGI
S
T
A
A
S
L
A
E
I
R
S
EFPAS
T
M
IASGG
L
Q
D
A
L
D
V
A
K
A
I
ALGASC
T
G
M
A
G
H
F
L
K
A
L
TDSGEE
G
L
L
E
E
I
Q
L
I
L
E
E
L
K
L
I
M
T
V
L
G
A
R
T
I
A
D
LQKA
P
L
V
I
KGETH
H
W
L
T
ERGVNTSSYSVR
99
Fugue
92.34
99%
-117
- C3 -
1P0K
1
IDI2_BACSU
B:
[22-349]
------------------------
E
T
G
L
D
D
I
T
F
V
H
V
S
L
P
D
L
A
L
E
Q
V
D
I
S
T
K
I
G
E
L
S
S
S
S
P
I
F
I
N
A
M
T
G
G
-
G
G
K
L
T
Y
E
I
N
K
S
L
A
R
A
A
S
Q
A
G
I
P
L
A
V
G
S
Q
M
S
A
L
K
D
P
S
E
R
L
S
Y
E
I
V
R
K
E
N
P
N
G
L
I
F
A
N
L
G
S
E
A
T
A
A
-----
Q
A
K
E
----
A
V
E
M
I
G
A
N
A
L
Q
I
H
L
N
V
I
Q
E
I
V
M
R
S
----
F
S
-
G
A
L
K
R
I
E
Q
I
C
S
R
V
S
V
P
V
I
V
K
E
V
G
F
G
M
S
K
A
S
A
G
K
L
Y
E
A
G
A
A
A
V
D
I
G
G
---------------
R
Q
I
S
F
-------
F
N
S
W
G
I
S
T
A
A
S
L
A
E
I
R
S
E
F
P
A
S
T
M
I
A
S
G
G
L
Q
D
A
L
D
V
A
K
A
I
A
L
G
A
S
C
T
G
M
A
G
H
F
L
K
A
L
T
D
S
G
E
E
G
L
L
E
E
I
Q
L
I
L
E
E
L
K
L
I
M
T
V
L
G
A
R
T
I
A
D
L
Q
K
A
P
L
V
I
K
G
E
T
H
H
W
L
T
E
R
G
V
N
T
S
S
Y
S
V
R
22
PsiBlast_CBE
92.22
100%
-118
- C3 -
1P0K
1
IDI2_BACSU
B:
[22-349]
------------------------
E
T
G
L
D
D
I
T
F
V
H
V
S
L
P
D
L
A
L
E
Q
V
D
I
S
T
K
I
G
E
L
S
S
S
S
P
I
F
I
N
A
M
T
G
G
-
G
G
K
L
T
Y
E
I
N
K
S
L
A
R
A
A
S
Q
A
G
I
P
L
A
V
G
S
Q
M
S
A
L
K
D
P
S
E
R
L
S
Y
E
I
V
R
K
E
N
P
N
G
L
I
F
A
N
L
G
S
E
A
T
A
A
-----
Q
A
K
E
----
A
V
E
M
I
G
A
N
A
L
Q
I
H
L
N
V
I
Q
E
I
V
M
----
R
S
F
S
-
G
A
L
K
R
I
E
Q
I
C
S
R
V
S
V
P
V
I
V
K
E
V
G
F
G
M
S
K
A
S
A
G
K
L
Y
E
A
G
A
A
A
V
D
I
G
G
---------------
R
Q
I
S
F
-------
F
N
S
W
G
I
S
T
A
A
S
L
A
E
I
R
S
E
F
P
A
S
T
M
I
A
S
G
G
L
Q
D
A
L
D
V
A
K
A
I
A
L
G
A
S
C
T
G
M
A
G
H
F
L
K
A
L
T
D
S
G
E
E
G
L
L
E
E
I
Q
L
I
L
E
E
L
K
L
I
M
T
V
L
G
A
R
T
I
A
D
L
Q
K
A
P
L
V
I
K
G
E
T
H
H
W
L
T
E
R
G
V
N
T
S
S
Y
S
V
R
21
PsiBlast_CBE
91.79
100%
-123
- C3 -
1P0N
2
IDI2_BACSU
B:
[22-349]
------------------------
E
T
G
L
D
D
I
T
F
V
H
V
S
L
P
D
L
A
L
E
Q
V
D
I
S
T
K
I
G
E
L
S
S
S
S
P
I
F
I
N
A
M
T
G
G
-
G
G
K
L
T
Y
E
I
N
K
S
L
A
R
A
A
S
Q
A
G
I
P
L
A
V
G
S
Q
M
S
A
L
K
D
P
S
E
R
L
S
Y
E
I
V
R
K
E
N
P
N
G
L
I
F
A
N
L
G
S
E
A
T
A
A
-----
Q
A
K
E
----
A
V
E
M
I
G
A
N
A
L
Q
I
H
L
N
V
I
Q
E
I
V
M
------
F
S
-
G
A
L
K
R
I
E
Q
I
C
S
R
V
S
V
P
V
I
V
K
E
V
G
F
G
M
S
K
A
S
A
G
K
L
Y
E
A
G
A
A
A
V
D
I
G
G
---------------
R
Q
I
S
F
-------
F
N
S
W
G
I
S
T
A
A
S
L
A
E
I
R
S
E
F
P
A
S
T
M
I
A
S
G
G
L
Q
D
A
L
D
V
A
K
A
I
A
L
G
A
S
C
T
G
M
A
G
H
F
L
K
A
L
T
D
S
G
E
E
G
L
L
E
E
I
Q
L
I
L
E
E
L
K
L
I
M
T
V
L
G
A
R
T
I
A
D
L
Q
K
A
P
L
V
I
K
G
E
T
H
H
W
L
T
E
R
G
V
N
T
S
S
Y
S
V
R
108
HHSearch
90.99
100%
-117
- C3 -
1P0K
1
IDI2_BACSU
A:
[21-349]
-----------------------
R
E
T
G
L
D
D
I
T
F
V
H
V
S
L
P
D
L
A
L
E
Q
V
D
I
S
T
K
I
G
E
L
S
S
S
S
P
I
F
I
N
A
M
T
G
G
-
G
G
K
L
T
Y
E
I
N
K
S
L
A
R
A
A
S
Q
A
G
I
P
L
A
V
G
S
Q
M
S
A
L
K
D
P
S
E
R
L
S
Y
E
I
V
R
K
E
N
P
N
G
L
I
F
A
N
L
G
S
E
A
T
A
A
-----
Q
A
K
E
----
A
V
E
M
I
G
A
N
A
L
Q
I
H
L
N
V
I
Q
E
I
--------
F
S
-
G
A
L
K
R
I
E
Q
I
C
S
R
V
S
V
P
V
I
V
K
E
V
G
F
G
M
S
K
A
S
A
G
K
L
Y
E
A
G
A
A
A
V
D
I
G
G
---------------
R
Q
I
S
F
-------
F
N
S
W
G
I
S
T
A
A
S
L
A
E
I
R
S
E
F
P
A
S
T
M
I
A
S
G
G
L
Q
D
A
L
D
V
A
K
A
I
A
L
G
A
S
C
T
G
M
A
G
H
F
L
K
A
L
T
D
S
G
E
E
G
L
L
E
E
I
Q
L
I
L
E
E
L
K
L
I
M
T
V
L
G
A
R
T
I
A
D
L
Q
K
A
P
L
V
I
K
G
E
T
H
H
W
L
T
E
R
G
V
N
T
S
S
Y
S
V
R
1
PsiBlast_PDB
90.58
100%
-117
- C3 -
1P0K
1
IDI2_BACSU
A:
[21-349]
-----------------------
R
E
T
G
L
D
D
I
T
F
V
H
V
S
L
P
D
L
A
L
E
Q
V
D
I
S
T
K
I
G
E
L
S
S
S
S
P
I
F
I
N
A
M
T
G
G
-
G
G
K
L
T
Y
E
I
N
K
S
L
A
R
A
A
S
Q
A
G
I
P
L
A
V
G
S
Q
M
S
A
L
K
D
P
S
E
R
L
S
Y
E
I
V
R
K
E
N
P
N
G
L
I
F
A
N
L
G
S
E
A
T
A
A
-----
Q
A
K
E
----
A
V
E
M
I
G
A
N
A
L
Q
I
H
L
N
V
I
Q
E
I
--------
F
S
-
G
A
L
K
R
I
E
Q
I
C
S
R
V
S
V
P
V
I
V
K
E
V
G
F
G
M
S
K
A
S
A
G
K
L
Y
E
A
G
A
A
A
V
D
I
G
G
---------------
R
Q
I
S
F
-------
F
N
S
W
G
I
S
T
A
A
S
L
A
E
I
R
S
E
F
P
A
S
T
M
I
A
S
G
G
L
Q
D
A
L
D
V
A
K
A
I
A
L
G
A
S
C
T
G
M
A
G
H
F
L
K
A
L
T
D
S
G
E
E
G
L
L
E
E
I
Q
L
I
L
E
E
L
K
L
I
M
T
V
L
G
A
R
T
I
A
D
L
Q
K
A
P
L
V
I
K
G
E
T
H
H
W
L
T
E
R
G
V
N
T
S
S
Y
S
V
R
2
PsiBlast_PDB
88.87
100%
-112
- C3 -
1P0N
1
IDI2_BACSU
A:
[22-349]
------------------------
E
T
G
L
D
D
I
T
F
V
H
V
S
L
P
D
L
A
L
E
Q
V
D
I
S
T
K
I
G
E
L
S
S
S
S
P
I
F
I
N
A
M
T
G
G
-
G
G
K
L
T
Y
E
I
N
K
S
L
A
R
A
A
S
Q
A
G
I
P
L
A
V
G
S
Q
M
S
A
L
K
D
P
S
E
R
L
S
Y
E
I
V
R
K
E
N
P
N
G
L
I
F
A
N
L
G
S
E
A
T
A
A
-----
Q
A
K
E
----
A
V
E
M
I
G
A
N
A
L
Q
I
H
L
N
V
I
Q
E
I
--------
F
S
-
G
A
L
K
R
I
E
Q
I
C
S
R
V
S
V
P
V
I
V
K
E
V
G
F
G
M
S
K
A
S
A
G
K
L
Y
E
A
G
A
A
A
V
D
I
G
G
---------------
R
Q
I
S
F
-------
F
N
S
W
G
I
S
T
A
A
S
L
A
E
I
R
S
E
F
P
A
S
T
M
I
A
S
G
G
L
Q
D
A
L
D
V
A
K
A
I
A
L
G
A
S
C
T
G
M
A
G
H
F
L
K
A
L
T
D
S
G
E
E
G
L
L
E
E
I
Q
L
I
L
E
E
L
K
L
I
M
T
V
L
G
A
R
T
I
A
D
L
Q
K
A
P
L
V
I
K
G
E
T
H
H
W
L
T
E
R
G
V
N
T
S
S
Y
S
V
R
14
PsiBlast_PDB
73.80
35%
-97
- C3 -
4N02
4
IDI2_STRPS
A:
[26-346]
-----
R
K
D
E
H
I
L
Y
A
L
---
E
-
Q
K
S
S
Y
N
S
F
D
E
V
E
L
I
H
S
S
L
P
L
Y
N
L
D
E
I
D
L
S
T
E
F
A
G
R
K
W
D
F
P
F
Y
I
N
A
M
T
G
G
-
S
N
K
-
G
R
E
I
N
Q
K
L
A
Q
V
A
E
S
C
G
I
L
F
V
T
G
S
Y
S
A
A
L
K
N
P
T
D
D
-
S
F
S
-
V
K
S
S
H
P
N
L
L
L
G
T
N
I
G
L
D
K
P
V
E
-----
L
G
L
Q
----
T
V
E
E
M
N
P
V
L
L
Q
V
H
V
N
V
M
Q
E
L
L
M
P
E
G
E
R
K
F
R
-
S
W
Q
S
H
L
A
D
Y
S
K
Q
I
P
V
P
I
V
L
K
E
V
G
F
G
M
D
A
K
T
I
E
R
A
Y
E
F
G
V
R
T
V
D
L
S
G
R
G
G
T
S
F
A
Y
I
E
N
-
R
R
S
G
Q
R
D
Y
-------
L
N
Q
W
G
Q
S
T
M
Q
A
L
L
N
A
Q
E
W
K
D
K
V
E
L
L
V
S
G
G
V
R
N
P
L
D
M
I
K
C
L
V
F
G
A
K
A
V
G
L
S
R
T
V
L
E
L
V
E
T
Y
T
V
E
E
V
I
G
I
V
Q
G
W
K
A
D
L
R
L
I
M
C
S
L
N
C
A
T
I
A
D
L
Q
K
V
D
Y
L
L
Y
G
K
------------------
110
HHSearch
73.25
34%
-97
- C3 -
4N02
4
IDI2_STRPS
A:
[23-354]
--
T
T
N
R
K
D
E
H
I
L
Y
A
L
---
E
Q
K
-
S
S
Y
N
S
F
D
E
V
E
L
I
H
S
S
L
P
L
Y
N
L
D
E
I
D
L
S
T
E
F
A
G
R
K
W
D
F
P
F
Y
I
N
A
M
T
G
G
-
S
-
N
K
G
R
E
I
N
Q
K
L
A
Q
V
A
E
S
C
G
I
L
F
V
T
G
S
Y
S
A
A
L
K
N
P
-
T
D
D
S
F
-
S
V
K
S
S
H
P
N
L
L
L
G
T
N
I
G
L
D
K
P
V
E
-----
L
G
L
Q
----
T
V
E
E
M
N
P
V
L
L
Q
V
H
V
N
V
M
Q
E
L
L
M
P
E
G
E
R
K
F
R
-
S
W
Q
S
H
L
A
D
Y
S
K
Q
I
P
V
P
I
V
L
K
E
V
G
F
G
M
D
A
K
T
I
E
R
A
Y
E
F
G
V
R
T
V
D
L
S
G
R
G
G
T
S
F
A
Y
I
E
N
R
R
S
G
Q
R
-
D
Y
-------
L
N
Q
W
G
Q
S
T
M
Q
A
L
L
N
A
Q
E
W
K
D
K
V
E
L
L
V
S
G
G
V
R
N
P
L
D
M
I
K
C
L
V
F
G
A
K
A
V
G
L
S
R
T
V
L
E
L
V
E
T
Y
T
V
E
E
V
I
G
I
V
Q
G
W
K
A
D
L
R
L
I
M
C
S
L
N
C
A
T
I
A
D
L
Q
K
V
D
Y
L
L
Y
G
K
L
K
E
A
K
D
Q
M
----------
55
PsiBlast_CBE
69.36
37%
7
- C3 -
2ZRU
1
IDI2_SULSH
B:
[9-361]
-------
V
E
H
V
E
I
A
A
FEN
V
D
G
L
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
----
N
E
L
G
-
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
GYGLK
E
F
Q
D
----
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
R
G
N
W
KAESAKN
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
E
-
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
---
50
PsiBlast_CBE
69.23
37%
12
- C3 -
2ZRV
1
IDI2_SULSH
D:
[7-361]
-----
R
K
V
E
H
V
E
I
A
A
FEN
V
D
G
L
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
N
E
L
G
-
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
GYGLK
E
F
Q
D
----
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
R
G
N
W
KAESAKN
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
E
-
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
---
3
PsiBlast_PDB
68.57
37%
7
- C3 -
2ZRU
1
IDI2_SULSH
A:
[9-361]
-------
V
E
H
V
E
I
A
A
F
EN
V
D
G
L
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
----
N
E
L
G
-
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
GYG
L
K
E
F
Q
D
----
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
R
G
N
W
K
A
E
S
A
K
N
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
E
-
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
---
52
PsiBlast_CBE
68.49
37%
12
- C3 -
2ZRV
1
IDI2_SULSH
B:
[7-361]
-----
R
K
V
E
H
V
E
I
A
A
FEN
V
D
G
L
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
N
E
L
G
-
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
GYGLK
E
F
Q
D
----
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
R
G
N
W
KAESAKN
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
E
-
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
---
51
PsiBlast_CBE
68.38
37%
13
- C3 -
2ZRV
1
IDI2_SULSH
C:
[7-361]
-----
R
K
V
E
H
V
E
I
A
A
FEN
V
D
G
L
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
N
E
L
G
-
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
GYGLK
E
F
Q
D
----
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
R
G
N
W
KAESAKN
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
E
-
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
---
23
PsiBlast_CBE
68.34
37%
14
- C3 -
3VKJ
1
IDI2_SULSH
D:
[7-361]
-----
R
K
V
E
H
V
E
I
A
A
FEN
V
D
G
L
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
N
E
L
G
-
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
GYGLK
E
F
Q
D
----
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
R
G
N
W
KAESAKN
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
E
-
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
---
32
PsiBlast_CBE
68.26
37%
14
- C3 -
3B04
2
IDI2_SULSH
D:
[7-361]
-----
R
K
V
E
H
V
E
I
A
A
FEN
V
D
G
L
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
N
E
L
G
-
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
GYGLK
E
F
Q
D
----
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
R
G
N
W
KAESAKN
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
E
-
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
---
24
PsiBlast_CBE
68.26
37%
18
- C3 -
3VKJ
1
IDI2_SULSH
C:
[7-361]
-----
R
K
V
E
H
V
E
I
A
A
FEN
V
D
G
L
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
N
E
L
G
-
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
GYGLK
E
F
Q
D
----
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
R
G
N
W
KAESAKN
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
E
-
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
---
54
PsiBlast_CBE
68.19
37%
10
- C3 -
2ZRU
1
IDI2_SULSH
C:
[9-361]
-------
V
E
H
V
E
I
A
A
FEN
V
D
G
L
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
----
N
E
L
G
-
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
GYGLK
E
F
Q
D
----
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
R
G
N
W
KAESAKN
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
E
-
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
---
53
PsiBlast_CBE
68.07
37%
7
- C3 -
2ZRU
1
IDI2_SULSH
D:
[9-361]
-------
V
E
H
V
E
I
A
A
FEN
V
D
G
L
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
----
N
E
L
G
-
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
GYGLK
E
F
Q
D
----
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
R
G
N
W
KAESAKN
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
E
-
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
---
25
PsiBlast_CBE
68.07
37%
17
- C3 -
3VKJ
1
IDI2_SULSH
B:
[7-361]
-----
R
K
V
E
H
V
E
I
A
A
FEN
V
D
G
L
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
N
E
L
G
-
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
GYGLK
E
F
Q
D
----
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
R
G
N
W
KAESAKN
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
E
-
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
---
6
PsiBlast_PDB
67.91
37%
17
- C3 -
2ZRX
3
IDI2_SULSH
A:
[7-361]
-----
R
K
V
E
H
V
E
I
A
A
FEN
V
D
G
L
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
N
E
L
G
-
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
GYG
L
K
E
F
Q
D
----
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
R
G
N
W
K
A
E
S
A
K
N
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
E
-
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
---
16
PsiBlast_PDB
61.77
34%
-13
- C3 -
1VCF
2
IDI2_THET2
A:
[23-321]
----------------------
K
T
T
T
G
L
E
G
F
R
L
R
Y
Q
A
L
A
G
L
A
L
S
E
V
D
L
T
T
P
F
L
G
K
T
L
K
A
P
F
L
I
G
A
M
T
--E
N
G
E
---
R
I
N
L
A
L
A
E
A
A
E
A
L
G
V
G
M
M
L
G
S
G
R
I
L
L
E
R
P
E
A
L
R
S
F
R
-
V
R
K
V
A
P
K
A
L
L
I
A
N
L
G
L
A
Q
L
R
R
-----
Y
G
R
D
D
L
L
R
L
V
E
M
L
E
A
D
A
L
A
F
H
V
N
P
L
Q
E
A
V
Q
-
R
G
D
T
D
F
R
-
G
L
V
E
R
L
A
E
L
L
P
-
L
P
F
P
V
M
V
K
E
V
G
H
G
L
S
R
E
A
A
L
A
L
R
D
L
P
L
A
A
V
D
V
A
G
A
G
G
T
S
W
A
R
V
E
E
W
V
-------E------
L
C
E
I
G
I
P
T
A
R
A
I
L
E
V
R
E
V
L
P
H
L
P
L
V
A
S
G
G
V
Y
T
G
T
D
G
A
K
A
L
A
L
G
A
D
L
L
A
V
A
R
P
L
L
R
P
A
L
E
-
G
A
E
R
V
A
A
W
I
G
D
Y
L
E
E
L
R
T
A
L
F
A
I
G
A
R
N
--------------------------------