@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu23110: (2016-07-06 )
MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAENDLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSITVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSLLAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTKIPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTILVTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVLLMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVDDIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKIIRKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVHSVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHNGSITVHSRIDKGTTFSFYIPTKR
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.-......160.......170.......180.......190....-...200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320......--.330.-.......340--.-----........350.......360.......370.......380.......390....-..-.400.......410.......420.......430.......440.......450.......-----460----...--.....470...----.....480.......490.......500--.---.......--510.......520.......530.......540.......550.......560.......570.......580.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
F
W
K
S
V
V
G
K
L
W
F
T
I
L
S
L
V
L
I
V
L
F
I
L
T
V
L
L
L
E
F
I
E
NYH
V
E
E
A
E
N
D
L
T
Q
L
A
N
K
V
A
V
I
L
ENHE
D
Q
A
L
A
R
S
I
T
W
E
L
ADNL
T
S
I
A
I
I
QDEKNHWYSPNDKNR
L
S
S
I
T
V
E
Q
I
QH
D
K
D
L
N
K
A
L
K
D
H
K
K
V
S
K
RTGLSDTDTDNE
R
L
I
V
GVPYEKDGKK
G
M
-
V
F
L
S
Q
S
L
L
AVKDTTKH
T
T
R
Y
I
F
L
A
A
G
I
A
I
V
L
T
T
F
F
A
F
F
L
SSRV-
T
Y
P
L
R
K
M
R
E
G
A
Q
D
L
AKGKFDTKI
P
I
L
T
Q
D
E
I
G
E
L
A
T
A
F
N
Q
MGR
Q
L
N
F
H
I
NAL
N
Q
E
K
E
Q
L
S
N
I
L
S
S
MAD
G
V
I
T
I
NID
G
T
I
L
V
TNP
P
A
E
R
F
L
Q
A
W
Y
Y
EQNMNIKEGDNLP
P
E
A
K
E
L
F
Q
N
A
V
S
T
E
K
E
Q
M
I
E
M
T
LQ--GR
S
-
W
-
V
L
L
MS
P
L
Y
----
A
-----
E
S
H
V
R
G
A
V
A
V
L
R
D
M
T
E
E
R
R
L
D
K
L
R
E
D
F
I
A
N
V
S
H
E
L
R
T
P
I
S
M
L
Q
G
Y
S
E
A
I
V
D
D
IAS-
S
E
-
E
D
R
K
E
I
A
Q
I
I
Y
DESL
R
M
G
R
L
V
N
D
L
L
D
L
A
R
MESGHTG
L
H
Y
E
KI
N
V
N
E
F
L
E
K
I
I
R
K
FSGVAKE-----K
N
-----
I
A
L--DHDISL-
T
E
E
E
----FMF
D
E
D
K
M
E
Q
V
F
T
N
L
I
D
N
A
L
R
HTSAG
G
---
S
---
V
S
I
S
V
H
S--VKD
G
L
K
I
D
I
KDSGSGIPE
E
D
L
P
F
I
F
E
R
F
Y
K
A
D
KARTRGRAGTG
L
G
L
A
I
V
K
N
I
V
E
AHNG
S
I
T
V
H
S
RIDKG
T
T
F
S
F
YIPTKR
21
PsiBlast_CBE
68.98
97%
-107
- C5 -
4ZR7
4
RESE_BACSU
D:
[2-125]
-------------------------------------
N
A
E
E
A
E
N
D
L
T
Q
L
A
N
K
V
A
V
I
L
E
N
H
E
D
Q
A
L
A
R
S
I
T
W
E
L
A
D
N
L
T
S
I
A
I
I
Q
D
E
K
N
H
W
Y
S
P
N
-----
S
S
I
T
V
E
Q
I
Q
H
D
K
D
L
N
K
A
L
K
D
H
K
K
V
S
K
R
T
G
L
S
D
T
D
T
D
N
E
R
L
I
V
G
V
P
Y
E
K
D
G
K
K
G
M
-
V
F
L
S
Q
S
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
68.86
30%
25
- C3 -
4I5S
-
?
A:
[37-432]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
A
L
E
C
N
-
I
L
D
I
L
D
D
D
S
Y
T
-
Y
N
D
L
I
-
T
K
T
P
E
I
V
L
T
R
R
D
EY
D
E
F
I
T
L
R
I
R
F
A
L
N
R
----
R
E----
S
G
F
I
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
R
E
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
A
L
T
--
E
-
S
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
-----
S
H
L
D
V
E
L
T
N
F
T
A
F
M
N
Y
I
L
D
R
F
D
Q
I
Q
S
Q
-----
Q
S
T-----
E
I
--
I
R
D
Y
P
D
-
K
S
V
W
----
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
G
---
K
---
V
T
I
T
M
Q
T
--
T
D
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
---
2
PsiBlast_PDB
67.90
31%
59
- C3 -
4I5S
-
?
A:
[37-432]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
-
E
Q
A
L
E
C
N
I
L
D
I
L
D
D
D
S
Y
T
Y
--
N
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
--
E
Y
D
-
E
-
F
I
T
L
R
I
R
F
----
A
L
NRRE
S
G
F
I
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
R
E
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
-
D
D
G
A
L
-
T
E
-
S
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
-----
S
H
L
D
V
E
L
T
N
F
T
A
F
M
N
Y
I
L
D
R
F
D
Q
I
Q
S
Q
-----
Q
S
-----
T
------
E
I
I
R
-
D
Y
P
D
K
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
G
---
K
---
V
T
I
T
M
Q
T
--
T
D
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
---
45
Fugue
67.74
30%
8
- C3 -
4I5S
-
?
A:
[37-432]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
--
T
R
E
Q
A
L
E
C
N
I
L
D
I
L
D
D
D
S
Y
T
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
E
--
Y
D
E
-
F
-
I
T
L
R
I
R
F
A
L
NRR
E
-----
S
G
F
I
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
R
E
R
R
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
-
A
L
-
T
E
-
S
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
S
H
-----
L
D
V
E
L
T
N
F
T
A
F
M
N
Y
I
L
D
R
F
D
Q
I
Q
S
Q
-----
Q
S
-----
T
E
I
--
I
R
D
Y
P
D
-
K
S
V
W
----
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
G
---
K
---
V
T
I
T
M
Q
T
--
T
D
T
Q
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
---
4
PsiBlast_PDB
65.08
36%
20
- C3 -
4U7O
1
?
A:
[25-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
D
N
D
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
-
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
DDNPA
K
Y
-----
Y
T
I
--
K
R
E
F
T
K
-
R
D
L
W
----
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
---
V
---
V
T
C
R
L
L
E
--
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
---
60
HHSearch
64.64
37%
28
- C3 -
4U7O
1
?
A:
[25-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
D
N
D
R
K
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
-
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
-----
D
D
NPA
K
Y
Y
T
I
--
K
R
E
F
T
K
-
R
D
L
W
----
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
---
V
---
V
T
C
R
L
L
E
--
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
-
1
PsiBlast_PDB
64.62
97%
-82
- C5 -
4ZR7
5
RESE_BACSU
A:
[5-126]
----------------------------------------
E
A
E
N
D
L
T
Q
L
A
N
K
V
A
V
I
L
E
N
H
E
D
Q
A
L
A
R
S
I
T
W
E
L
A
D
N
L
T
S
I
A
I
I
Q
D
E
K
N
H
W
Y
S
P
N
----
L
S
S
I
T
V
E
Q
I
Q
H
D
K
D
L
N
K
A
L
K
D
H
K
K
V
S
K
R
T
G
L
S
D
T
D
T
D
N
E
R
L
I
V
G
V
P
Y
E
K
D
G
K
K
G
M
-
V
F
L
S
Q
S
L
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
62.62
96%
-75
* C5 *
4ZR7
5
RESE_BACSU
A:
[5-126]
----------------------------------------
E
A
E
N
D
L
T
Q
L
A
N
K
V
A
V
I
L
E
N
H
E
D
Q
A
L
A
R
S
I
T
W
E
L
A
D
N
L
T
S
I
A
I
I
Q
D
E
K
N
H
W
Y
S
P
N
----
L
S
S
I
T
V
E
Q
I
Q
H
D
K
D
L
N
K
A
L
K
D
H
K
K
V
S
K
R
T
G
L
S
D
T
D
T
D
N
E
R
L
I
V
G
V
P
Y
E
K
-
D
G
K
K
G
M
V
F
L
S
Q
S
L
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
62.10
28%
-107
- C3 -
4BIX
3
CPXA_ECOLI
A:
[71-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
L
E
R
M
M
T
S
Q
Q
R
L
-------
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
-
E
L
E
R
-----
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
-
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
-----
M
G
-----
K
S
L
--
T
V
N
F
P
P
-
G
P
W
P
----
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
---
V
G
F
A
V
D
----
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
--------
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
---
19
PsiBlast_PDB
61.57
28%
-90
- C3 -
4CB0
6
CPXA_ECOLI
A:
[71-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
L
E
R
M
M
T
S
Q
Q
R
L
-------
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
-
E
L
E
R
-----
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
-
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
-----
M
G
-----
K
S
L
--
T
V
N
F
P
P
-
G
P
W
P
----
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
---
V
G
F
A
V
D
----
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
---
65
HHSearch
60.55
31%
-93
- C3 -
4Q20
-
DIVL_CAUCR
A:
[538-757]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
L
K
R
D
F
V
G
N
V
S
Y
E
L
R
T
P
L
T
T
I
I
G
Y
S
E
L
L
E
R
A
D
----
S
-
E
R
G
R
N
H
V
A
A
V
R
A
A
A
T
Q
L
A
R
S
I
D
D
V
L
D
M
A
Q
I
D
A
G
E
M
A
L
E
I
E
D
I
R
V
S
D
L
L
L
N
A
Q
E
R
A
L
K
D
A
Q
L
-----
G
G
-----
V
T
L
--
A
V
E
C
E
E
-
D
V
G
L
----
I
R
G
D
G
K
R
L
A
Q
T
L
D
H
L
V
E
N
A
L
R
Q
T
P
P
G
G
---
R
---
V
T
L
S
A
R
R
--
A
L
G
E
V
R
L
D
V
S
D
T
G
R
G
V
P
F
H
V
Q
A
H
I
F
D
R
F
V
G
R
D
------
R
G
G
P
G
L
G
L
A
L
V
K
A
L
V
E
L
H
G
G
W
V
A
L
E
S
E
P
G
N
G
S
T
F
T
C
H
L
P
E
T
-
16
PsiBlast_PDB
60.03
28%
-98
- C3 -
4BIZ
3
CPXA_ECOLI
A:
[71-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
L
E
R
M
M
T
S
Q
Q
R
L
-------
L
S
D
I
S
E
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
-
E
L
E
R
-----
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
-
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
-----
M
G
-----
K
S
L
--
T
V
N
F
P
P
-
G
P
W
P
----
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
---
V
G
F
A
V
D
----
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
--
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
---
15
PsiBlast_PDB
58.73
28%
-114
- C3 -
4BIY
3
CPXA_ECOLI
A:
[71-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
L
E
R
M
M
T
S
Q
Q
R
L
-------
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
-
E
L
E
R
-----
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
-
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
-----
M
G
-----
K
S
L
--
T
V
N
F
P
P
-
G
P
W
P
----
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
---
V
G
F
A
V
D
----
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
---------
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
---
57
HHSearch
58.54
26%
-109
- C3 -
4BIX
3
CPXA_ECOLI
A:
[61-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
G
A
S
F
N
Q
V
V
T
A
L
E
R
M
M
----------------------------------------------------------------------------------------------------------------------------------
T
S
Q
Q
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
-------
G
E
S
K
E
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
-
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
-----
M
G
-----
K
S
L
--
T
V
N
F
P
P
-
G
P
W
P
----
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
--------
I
E
V
G
F
A
V
--
D
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
--------
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
-
18
PsiBlast_PDB
58.46
28%
-89
- C3 -
4BIV
2
CPXA_ECOLI
A:
[71-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
L
E
R
M
M
T
S
Q
Q
R
L
-------
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
-
E
L
E
R
-----
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
-
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
-----
M
G
-----
K
S
L
--
T
V
N
F
P
P
-
G
P
W
P
----
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
---
V
G
F
A
V
D
----
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
---
13
PsiBlast_PDB
58.13
28%
-87
- C3 -
4BIW
5
CPXA_ECOLI
A:
[71-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
L
E
R
M
M
T
S
Q
Q
R
L
-------
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
-
E
L
E
R
-----
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
-
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
-----
M
G
-----
K
S
L
--
T
V
N
F
P
P
-
G
P
W
P
----
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
---
V
G
F
A
V
D
----
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
A
R
D
R
E
S
G
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
---
3
PsiBlast_PDB
57.97
36%
9
- C3 -
4U7N
-
?
A:
[386-608]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
-
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
DDN---
Y
-----
Y
T
I
--
K
R
E
F
T
K
-
R
D
L
W
----
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
---
V
---
V
T
C
R
L
L
E
--
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
-----------
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
---
12
PsiBlast_PDB
57.68
28%
-102
- C3 -
4BIU
-
CPXA_ECOLI
A:
[71-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
L
E
R
M
M
T
S
Q
Q
R
L
-------
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
-
E
L
E
R
-----
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
-
K
N
A
L
V
S
E
T
I
K
A
N
Q
L
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
-----
M
G
-----
K
S
L
--
T
V
N
F
P
P
-
G
P
W
P
----
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
---
V
G
F
A
V
D
----
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
----------
G
L
G
L
A
I
V
E
T
A
I
Q
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
---
24
PsiBlast_CBE
57.11
32%
67
- C3 -
3DGE
2
?
B:
[14-249]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
-
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
-----
H
N
-----
V
N
V
LF
E
S
N
V
P
C
-
P
V
E
A
----
Y
I
-
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
DKY
V
K
V
I
L
D
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
46
Fugue
57.04
27%
-121
- C3 -
1ID0
2
A:
[1-146]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
L
H
P
V
A
P
L
L
D
N
L
T
S
A
L
N
K
V
Y
Q
R
-----
K
G
-----
V
N
I
--
S
L
D
I
S
--
P
E
I
S
----
F
V
G
E
Q
N
D
F
V
E
V
M
G
N
V
L
D
N
A
C
K
Y
C
L
--
E
---
F
---
V
E
I
S
A
R
Q
--
T
D
E
H
L
Y
I
V
V
E
D
D
G
P
G
I
P
L
S
K
R
E
V
I
F
D
R
G
Q
R
V
D
T
L
R
P
----
G
Q
G
V
G
L
A
V
A
R
E
I
T
E
Q
Y
E
G
K
I
V
A
G
E
S
M
L
G
G
A
R
M
E
V
I
F
G
R
Q
H
76
HHSearch
54.03
41%
-68
- C3 -
3SL2
2
A:
[3-152]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
I
V
R
F
M
S
L
I
I
D
R
F
E
M
T
K
-
E
-----
Q
-------
E
F
--
I
R
N
L
P
D
-
R
D
L
Y
----
V
E
I
D
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
P
E
G
G
---
H
---
V
T
F
S
I
D
V
NE
E
E
E
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
Y
K
-
23
PsiBlast_CBE
53.98
32%
65
- C3 -
4JAV
6
?
B:
[14-248]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
D
R
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
-
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
-----
H
N
-----
V
N
V
L
F
E
S
N
V
P
C
-
P
V
E
A
----
Y
I
-
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
D
K
Y
V
K
V
I
L
D
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
-
22
PsiBlast_CBE
53.46
36%
28
- C3 -
4U7O
1
?
B:
[37-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
-
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
------
T
R
V
D
M
E
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
DDNPA
K
Y
-----
Y
T
I
--
K
R
E
F
T
K
-
R
D
L
W
----
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
---
V
---
V
T
C
R
L
L
E
--
T
H
N
Q
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
R
---
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
---
64
HHSearch
53.45
33%
55
- C3 -
2C2A
2
?
A:
[19-248]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
T
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
-
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
K
V
D
L
C
D
L
V
E
S
A
V
N
A
I
K
E
F
A
S
S
-----
H
N
-----
V
N
V
--
L
F
E
S
N
V
P
C
P
V
E
----
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
Y
---
V
K
V
I
L
D
E
--
K
D
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
---------
T
G
L
G
L
A
I
T
K
E
I
V
E
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
-