@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu23280: (2016-07-06 )
MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLKYGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDPNPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKIATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVILDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVLKILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSMKDVPLLQFTDITQIGRDIKLTAKPTKE
Atome Classification :
(22 SA)
.........10........20........30........40........50.......---.60---........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200....-...210--.........220......-.230.......240.......---250.......260.......270.......280-.......290.......300.......310........320.......330.......340.......350.......360
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
E
Y
Y
M
K
L
A
L
D
L
A
KQGEGQTESN
P
L
V
G
A
V
V
V
KD
G
Q
I
V
G
MGA
H
L
KYGEAH
A
E
V
H
A
I
H
MA---GAH---AEG
A
D
I
Y
V
T
LE
P
C
SHYGKTP
P
C
A
E
L
I
I
NSG
I
K
R
V
F
V
A
MRDPNPLVAGR
G
I
S
M
M
K
EAG
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
RTGL
P
Y
V
T
L
K
A
AASLD
G
K
I
ATSTGDSKW
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
TVKADNP
S
L
T
C
R-LPNV----
T
K
Q
P
V
R
V
I
L
D
T
V
LSIP
E
D
-
A
K
V
I
C
D
QIAP
T
W
I
F
TTARA
D
E
---
E
K
K
K
R
L
S
A
FG
V
N
I
F
T
L
ETERIQ
I
P
D
V
L
K
I
L
A
EE-G
I
M
S
V
Y
VEGGSAV
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
-
Y
F
A
P
K
LIGGTHAPSLISGEGFQSMKDVPLLQFT
D
I
T
QIGR
D
I
K
LTAKPTKE
4
PsiBlast_PDB
95.09
100%
-107
- C3 -
4G3M
2
RIBD_BACSU
A:
[13-372]
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
---
G
A
H
---
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
---
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
-
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
K
-
29
PsiBlast_CBE
94.53
100%
-106
- C3 -
2D5N
2
RIBD_BACSU
B:
[13-371]
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
---
G
A
H
---
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
---
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
-
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
--
22
PsiBlast_CBE
94.06
100%
-106
- C3 -
4G3M
3
RIBD_BACSU
C:
[13-371]
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
---
G
A
H
---
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
---
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
-
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
--
61
HHSearch
93.85
100%
-102
- C3 -
2B3Z
1
RIBD_BACSU
A:
[13-371]
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
---
G
A
H
---
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
---
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
-
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
--
51
Fugue
93.85
100%
-102
- C3 -
2B3Z
1
RIBD_BACSU
A:
[13-371]
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
---
G
A
H
---
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
---
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
-
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
--
1
PsiBlast_PDB
93.85
100%
-102
- C3 -
2B3Z
1
RIBD_BACSU
A:
[13-371]
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
---
G
A
H
---
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
---
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
-
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
--
32
PsiBlast_CBE
93.80
100%
-106
- C3 -
2B3Z
1
RIBD_BACSU
B:
[13-371]
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
---
G
A
H
---
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
---
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
-
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
--
25
PsiBlast_CBE
93.69
100%
-104
- C3 -
3EX8
2
RIBD_BACSU
C:
[13-371]
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
---
G
A
H
---
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
---
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
-
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
--
31
PsiBlast_CBE
93.61
100%
-106
- C3 -
2B3Z
1
RIBD_BACSU
C:
[13-371]
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
---
G
A
H
---
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
---
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
-
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
--
21
PsiBlast_CBE
93.42
100%
-102
- C3 -
4G3M
3
RIBD_BACSU
D:
[13-371]
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
---
G
A
H
---
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
---
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
-
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
--
27
PsiBlast_CBE
93.34
100%
-108
- C3 -
2D5N
1
RIBD_BACSU
D:
[13-371]
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
---
G
A
H
---
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
---
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
-
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
--
3
PsiBlast_PDB
93.34
100%
-100
- C3 -
3EX8
1
RIBD_BACSU
A:
[13-371]
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
---
G
A
H
---
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
---
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
-
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
--
23
PsiBlast_CBE
93.20
100%
-98
- C3 -
4G3M
3
RIBD_BACSU
B:
[13-371]
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
---
G
A
H
---
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
---
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
-
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
--
2
PsiBlast_PDB
92.82
100%
-103
- C3 -
2D5N
1
RIBD_BACSU
A:
[13-371]
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
---
G
A
H
---
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
---
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
-
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
--
26
PsiBlast_CBE
92.47
100%
-103
- C3 -
3EX8
1
RIBD_BACSU
B:
[13-371]
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
---
G
A
H
---
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
---
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
-
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
--
30
PsiBlast_CBE
92.19
100%
-102
- C3 -
2B3Z
1
RIBD_BACSU
D:
[13-371]
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
---
G
A
H
---
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
---
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
-
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
--
28
PsiBlast_CBE
91.98
100%
-105
- C3 -
2D5N
1
RIBD_BACSU
C:
[13-371]
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
---
G
A
H
---
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
---
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
-
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
--
24
PsiBlast_CBE
91.97
100%
-104
- C3 -
3EX8
1
RIBD_BACSU
D:
[13-371]
M
E
E
Y
Y
M
K
L
A
L
D
L
A
K
Q
G
E
G
Q
T
E
S
N
P
L
V
G
A
V
V
V
K
D
G
Q
I
V
G
M
G
A
H
L
K
Y
G
E
A
H
A
E
V
H
A
I
H
M
A
---
G
A
H
---
A
E
G
A
D
I
Y
V
T
L
E
P
C
S
H
Y
G
K
T
P
P
C
A
E
L
I
I
N
S
G
I
K
R
V
F
V
A
M
R
D
P
N
P
L
V
A
G
R
G
I
S
M
M
K
E
A
G
I
E
V
R
E
G
I
L
A
D
Q
A
E
R
L
N
E
K
F
L
H
F
M
R
T
G
L
P
Y
V
T
L
K
A
A
A
S
L
D
G
K
I
A
T
S
T
G
D
S
K
W
I
T
S
E
A
A
R
Q
D
A
Q
Q
Y
R
K
T
H
Q
S
I
L
V
G
V
G
T
V
K
A
D
N
P
S
L
T
C
R
-
L
P
N
V
----
T
K
Q
P
V
R
V
I
L
D
T
V
L
S
I
P
E
D
-
A
K
V
I
C
D
Q
I
A
P
T
W
I
F
T
T
A
R
A
D
E
---
E
K
K
K
R
L
S
A
F
G
V
N
I
F
T
L
E
T
E
R
I
Q
I
P
D
V
L
K
I
L
A
E
E
-
G
I
M
S
V
Y
V
E
G
G
S
A
V
H
G
S
F
V
K
E
G
C
F
Q
E
I
I
F
-
Y
F
A
P
K
L
I
G
G
T
H
A
P
S
L
I
S
G
E
G
F
Q
S
M
K
D
V
P
L
L
Q
F
T
D
I
T
Q
I
G
R
D
I
K
L
T
A
K
P
T
--
5
PsiBlast_PDB
67.55
42%
-32
- C3 -
3ZPC
4
?
A:
[28-379]
-
D
Q
Y
W
M
Q
Q
A
I
E
L
A
K
R
G
L
Y
S
T
K
P
N
P
N
V
G
C
V
I
V
K
D
D
Q
L
I
G
E
G
F
H
P
K
A
G
Q
P
H
A
E
V
F
A
L
R
Q
A
---
G
E
Q
---
A
Q
G
A
T
A
Y
V
T
L
E
P
C
A
H
Y
G
R
T
P
P
C
A
E
A
L
V
K
A
Q
V
K
K
V
V
V
A
C
P
D
P
N
P
L
V
A
G
K
G
V
Q
I
L
K
N
A
G
I
E
V
E
I
G
I
C
E
D
L
A
A
K
L
N
Q
G
F
L
K
A
M
S
T
G
M
P
Y
V
R
L
K
V
A
S
S
L
D
G
R
T
A
M
A
S
G
E
S
K
W
I
T
G
S
A
A
R
Q
D
V
Q
H
W
R
A
I
S
G
A
V
I
T
G
I
D
T
V
I
A
D
D
C
Q
L
N
V
R
S
L
H
N
I
DIET
V
A
Q
P
K
R
V
I
L
D
R
R
G
R
L
P
L
T
-
A
K
I
L
E
N
---
P
E
T
V
M
V
M
G
P
Y
R
Q
---
E
----
L
A
D
L
G
V
--
I
Q
L
E
I
Q
P
L
K
T
--
L
L
Q
T
L
S
K
Q
Y
Q
I
Y
D
V
L
I
E
A
G
A
T
L
S
S
A
F
L
Q
E
G
L
I
D
E
M
I
S
-
Y
V
A
P
T
L
L
G
Q
S
-
A
R
A
M
F
N
A
D
-
F
E
Y
M
A
Q
Q
L
R
F
K
L
L
D
V
I
Q
L
D
Q
D
I
R
L
R
L
I
P
T
Q
-
6
PsiBlast_PDB
66.63
42%
-31
- C3 -
3ZPG
10
?
A:
[28-378]
-
D
Q
Y
W
M
Q
Q
A
I
E
L
A
K
R
G
L
Y
S
T
K
P
N
P
N
V
G
C
V
I
V
K
D
D
Q
L
I
G
E
G
F
H
P
K
A
G
Q
P
H
A
E
V
F
A
L
R
Q
A
---
G
E
Q
---
A
Q
G
A
T
A
Y
V
T
L
E
P
C
A
H
Y
G
R
T
P
P
C
A
E
A
L
V
K
A
Q
V
K
K
V
V
V
A
C
P
D
P
N
P
L
V
A
G
K
G
V
Q
I
L
K
N
A
G
I
E
V
E
I
G
I
C
E
D
L
A
A
K
L
N
Q
G
F
L
K
A
M
S
T
G
M
P
Y
V
R
L
K
V
A
S
S
L
D
G
R
T
A
M
A
S
G
E
S
--
I
T
G
S
A
A
R
Q
D
V
Q
H
W
R
A
I
S
G
A
V
I
T
G
I
D
T
V
I
A
D
D
C
Q
L
N
V
R
S
L
H
N
I
DIET
V
A
Q
P
K
R
V
I
L
D
R
R
G
R
L
P
L
T
-
A
K
I
L
E
N
---
P
E
T
V
M
V
M
G
P
Y
R
Q
---
E
----
L
A
D
L
G
V
--
I
Q
L
E
I
Q
P
L
K
T
--
L
L
Q
T
L
S
K
Q
Y
Q
I
Y
D
V
L
I
E
A
G
A
T
L
S
S
A
F
L
Q
E
G
L
I
D
E
M
I
S
-
Y
V
A
P
T
L
L
G
Q
S
-
A
R
A
M
F
N
A
D
-
F
E
Y
M
A
Q
Q
L
R
F
K
L
L
D
V
I
Q
L
D
Q
D
I
R
L
R
L
I
P
T
--
64
HHSearch
61.90
39%
-8
- C3 -
2HXV
11
?
A:
[13-357]
M
Y
E
T
F
M
K
R
A
I
E
L
A
K
K
G
L
G
R
V
N
P
N
P
P
V
G
A
V
V
V
K
D
G
R
I
I
A
E
G
F
H
P
Y
F
G
G
P
H
A
E
R
M
A
I
E
S
A
---
R
K
K
GED
L
R
G
A
T
L
I
V
T
L
E
P
C
D
H
H
G
K
T
P
P
C
T
D
L
I
I
E
S
G
I
K
T
V
V
I
G
T
R
D
P
N
P
V
-
S
G
N
G
V
E
K
F
R
N
H
G
I
E
V
I
E
G
V
L
E
E
E
V
K
K
L
C
E
F
F
I
T
Y
V
T
K
K
R
P
F
V
A
L
K
Y
A
S
T
L
D
G
K
I
A
D
H
R
G
D
S
K
W
I
T
D
K
-
L
R
F
K
V
H
E
M
R
N
I
Y
S
A
V
L
V
G
A
G
T
V
L
K
D
N
P
Q
L
T
C
R
-
L
K
E
-----
G
R
N
P
V
R
V
I
L
D
R
K
G
V
L
S
G
K
V
F
R
V
F
E
E
-
N
A
R
V
I
V
F
T
E
S
E
E
A
E
---------
Y
P
P
H
V
E
K
A
L
---
S
D
C
S
V
E
S
I
L
R
N
L
Y
E
R
-
D
I
D
S
V
L
V
E
G
G
S
K
V
F
S
E
F
L
D
H
--
A
D
V
V
F
G
-
F
Y
S
T
K
I
F
G
K
-
G
L
D
--
V
F
S
G
Y
L
S
D
V
S
V
P
P
K
F
K
V
V
N
V
E
F
S
D
S
E
F
L
V
E
M
R
P
C
--
7
PsiBlast_PDB
58.89
42%
-7
- C3 -
2HXV
11
?
A:
[15-319]
--
E
T
F
M
K
R
A
I
E
L
A
K
K
G
L
G
R
V
N
P
N
P
P
V
G
A
V
V
V
K
D
G
R
I
I
A
E
G
F
H
P
Y
F
G
G
P
H
A
E
R
M
A
I
E
S
A
R
K
K
G
E
D
---
L
R
G
A
T
L
I
V
T
L
E
P
C
D
H
H
G
K
T
P
P
C
T
D
L
I
I
E
S
G
I
K
T
V
V
I
G
T
R
D
P
N
P
-
V
S
G
N
G
V
E
K
F
R
N
H
G
I
E
V
I
E
G
V
L
E
E
E
V
K
K
L
C
E
F
F
I
T
Y
V
T
K
K
R
P
F
V
A
L
K
Y
A
S
T
L
D
G
K
I
A
D
H
R
G
D
S
K
W
I
T
-
D
K
L
R
F
K
V
H
E
M
R
N
I
Y
S
A
V
L
V
G
A
G
T
V
L
K
D
N
P
Q
L
T
C
R
-
L
K
E
-----
G
R
N
P
V
R
V
I
L
D
R
K
G
V
L
S
G
K
-
V
F
R
V
F
E
E
N
A
R
V
I
V
F
T
E
S
E
E
A
E
YPP
H
V
E
K
A
L
S
D
C
S
V
E
------------
S
I
L
R
N
L
Y
E
R
-
D
I
D
S
V
L
V
E
G
G
S
K
V
F
S
E
F
L
D
H
A
---
D
V
V
F
G
F
Y
S
T
K
I
F
G
-------------------------------------------