@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu23570: (2016-07-06 )
MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKIHEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGAGTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLLEKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRIKQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDAYTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAELINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLKGIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTEEELDIILNPYEMTKPGIAGKELLEK
Atome Classification :
(32 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150...-...-.160-.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260........270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420......----.430.......440.......450.......460.......470...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLNG
Q
K
E
YR
V
E
K
DFLG
E
K
Q
I
E
A
D
V
Y
Y
G
I
Q
T
LRASENFPITGY
K
I
H
E
E
M
I
N
A
L
A
I
V
K
K
A
A
A
L
ANM
D
V
K
R
L
Y
E
G
I
G
Q
A
I
V
Q
A
A
D
E
I
LEGKWHD
Q
F
I
VDPIQGGAGTSMNM
N
A
N
E
V
IGN
R
A
L
E
I
MGHKKG
D
Y
I
H
LSPN
T
H
V
N
MSQSTNDVFP
T
A
I
H
I
S
-
T
L
K
-
L
L
E
K
-
L
L
K
T
M
E
D
M
H
S
V
F
K
Q
K
A
Q
E
F
D
S
V
I
K
M
G
R
T
H
L
QDAVPIRLG
Q
E
F
E
A
Y
S
R
V
L
E
R
D
I
K
R
I
K
Q
S
R
Q
H
L
Y
E
VNMG
A
T
AVGTGLNA
D
P
E
Y
I
K
Q
V
V
K
H
L
ADISGLP-LVGA
D
H
LVDATQNT
D
A
Y
T
E
V
S
A
S
L
K
V
C
M
M
N
M
S
K
I
A
N
D
L
R
LMASGPRAG
L
A
E
ISLPARQPGSSIMPGKV
N
P
V
M
A
E
L
I
N
Q
I
A
F
Q
V
IGNDN
T
I
C
L
ASEA
G
Q
L
E
L
N
VM
E
P
V
L
V
F
N
L
L
Q
S
I
S
I
M
N
N
G
F
R
S
F
T
D
N
C
L
KGIEA
N
E
K
R
M
K
Q
Y
V
E
KSA
G
V
I
T
AVNPHL
G
Y
E
A
A
A
R
I
A
----
R
E
A
IMT
G
Q
S
V
R
D
L
C
L
QHDVL
T
E
E
E
L
D
I
I
L
N
P
Y
EMTKPGIA
G
K
E
L
LEK
28
PsiBlast_CBE
99.60
72%
-93
- C3 -
3R6Q
1
?
H:
[6-466]
--------
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
-
V
L
S
-
L
L
N
Q
-
L
I
E
T
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
-
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
V
F
K
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
----
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
I
A
G
------
30
PsiBlast_CBE
98.90
72%
-94
- C3 -
3R6Q
2
?
D:
[6-466]
--------
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
-
V
L
S
-
L
L
N
Q
-
L
I
E
T
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
-
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
V
F
K
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
----
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
I
A
G
------
23
PsiBlast_CBE
98.79
72%
-91
- C3 -
3R6V
1
?
F:
[6-465]
--------
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
-
V
L
S
-
L
L
N
Q
-
L
I
E
T
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
-
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
V
F
K
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
----
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
I
A
-------
2
PsiBlast_PDB
98.62
72%
-94
- C3 -
3R6Q
1
?
A:
[6-466]
--------
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
-
V
L
S
-
L
L
N
Q
-
L
I
E
T
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
-
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
V
F
K
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
----
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
I
A
G
------
27
PsiBlast_CBE
98.47
72%
-88
- C3 -
3R6V
1
?
B:
[6-466]
--------
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
-
V
L
S
-
L
L
N
Q
-
L
I
E
T
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
-
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
V
F
K
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
----
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
I
A
G
------
68
HHSearch
97.96
72%
-94
- C3 -
3R6Q
1
?
A:
[5-466]
-------
V
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
-
V
L
S
-
L
L
N
Q
-
L
I
E
T
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
-
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
V
F
K
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
----
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
I
A
G
------
25
PsiBlast_CBE
97.94
72%
-92
- C3 -
3R6V
2
?
D:
[6-463]
--------
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
-
V
L
S
-
L
L
N
Q
-
L
I
E
T
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
-
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
V
F
K
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
----
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
---------
26
PsiBlast_CBE
97.72
72%
-93
- C3 -
3R6V
1
?
C:
[6-466]
--------
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
-
V
L
S
-
L
L
N
Q
-
L
I
E
T
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
-
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
V
F
K
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
----
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
I
A
G
------
29
PsiBlast_CBE
97.70
72%
-91
- C3 -
3R6Q
1
?
E:
[6-466]
--------
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
-
V
L
S
-
L
L
N
Q
-
L
I
E
T
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
-
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
V
F
K
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
----
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
I
A
G
------
22
PsiBlast_CBE
97.28
72%
-91
- C3 -
3R6V
1
?
G:
[6-466]
--------
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
-
V
L
S
-
L
L
N
Q
-
L
I
E
T
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
-
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
V
F
K
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
----
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
I
A
G
------
3
PsiBlast_PDB
96.77
72%
-94
- C3 -
3R6V
2
?
A:
[6-462]
--------
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
-
V
L
S
-
L
L
N
Q
-
L
I
E
T
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
-
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
V
F
K
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
----
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
----------
21
PsiBlast_CBE
96.61
72%
-91
- C3 -
3R6V
1
?
H:
[6-463]
--------
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
-
V
L
S
-
L
L
N
Q
-
L
I
E
T
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
-
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
V
F
K
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
----
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
---------
1
PsiBlast_PDB
95.99
72%
-88
- C3 -
1J3U
-
?
A:
[6-466]
--------
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
-
V
L
S
-
L
L
N
Q
-
L
I
E
T
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
-
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
V
F
K
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
----
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
I
A
G
------
24
PsiBlast_CBE
95.75
72%
-89
- C3 -
3R6V
2
?
E:
[6-463]
--------
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
-
V
L
S
-
L
L
N
Q
-
L
I
E
T
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
-
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
V
F
K
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
----
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
---------
34
PsiBlast_CBE
85.03
73%
-75
- C3 -
3R6Y
1
?
B:
[5-394]
-------
V
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
-
V
L
S
-
L
L
N
Q
-
L
I
E
T
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
-
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
V
F
K
S
F
T
E
N
C
L
K
G
I
K
A
N
----------------------------------------------------------------------------------
32
PsiBlast_CBE
83.07
73%
-79
- C3 -
3R6Y
1
?
F:
[5-394]
-------
V
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
-
V
L
S
-
L
L
N
Q
-
L
I
E
T
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
-
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
V
F
K
S
F
T
E
N
C
L
K
G
I
K
A
N
----------------------------------------------------------------------------------
31
PsiBlast_CBE
82.95
73%
-81
- C3 -
3R6Y
1
?
G:
[5-395]
-------
V
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
-
V
L
S
-
L
L
N
Q
-
L
I
E
T
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
-
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
-------
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
V
F
K
S
F
T
E
N
C
L
K
G
I
K
A
N
E
---------------------------------------------------------------------------------
33
PsiBlast_CBE
82.44
73%
-78
- C3 -
3R6Y
1
?
C:
[5-394]
-------
V
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
-
V
L
S
-
L
L
N
Q
-
L
I
E
T
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
-
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
-------
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
V
F
K
S
F
T
E
N
C
L
K
G
I
K
A
N
----------------------------------------------------------------------------------
4
PsiBlast_PDB
82.29
73%
-78
- C3 -
3R6Y
-
?
A:
[5-394]
-------
V
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
-
V
L
S
-
L
L
N
Q
-
L
I
E
T
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
-
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
V
F
K
S
F
T
E
N
C
L
K
G
I
K
A
N
----------------------------------------------------------------------------------
10
PsiBlast_PDB
73.76
41%
-16
- C3 -
3TV2
2
?
A:
[1-455]
--------
R
M
E
R
D
T
F
G
E
I
A
V
P
A
A
R
L
W
G
A
Q
T
Q
R
S
L
Q
N
F
K
I
S
T
E
K
Q
S
P
E
L
I
H
A
L
A
L
I
K
R
A
A
A
A
V
N
L
E
L
G
V
L
A
Q
D
K
A
N
A
I
V
A
A
A
D
E
I
I
A
G
R
H
A
D
E
F
P
L
A
V
W
Q
T
G
S
G
T
Q
T
N
M
N
L
N
E
V
I
A
N
R
A
S
E
L
L
G
G
E
R
G
E
S
R
A
V
H
P
N
D
D
V
N
R
G
Q
S
S
N
D
V
F
P
T
A
M
H
I
A
-
A
A
R
A
I
V
D
H
-
L
L
P
A
L
R
T
L
R
A
T
L
D
A
K
A
A
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
F
S
G
Y
V
A
Q
L
D
Q
G
I
R
H
V
E
A
A
L
P
H
L
Y
E
L
A
Q
G
G
T
A
V
G
T
G
L
N
A
H
P
K
F
A
A
G
V
A
A
E
I
G
R
L
T
G
L
P
-
F
V
S
A
P
N
K
F
E
V
M
A
A
A
D
A
L
V
F
A
H
G
A
L
K
T
V
A
A
S
L
M
K
I
A
N
D
I
R
W
L
A
S
G
P
R
C
G
L
G
E
L
S
I
P
E
N
E
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
S
E
A
V
T
M
L
C
C
Q
V
F
G
N
D
V
A
V
N
F
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
I
A
H
N
V
L
Q
S
V
R
L
L
A
D
G
A
Q
G
F
N
D
H
C
A
V
G
I
E
P
N
R
A
R
I
D
A
L
L
N
E
S
L
M
L
V
T
A
L
N
P
H
I
G
Y
D
K
A
A
Q
I
A
----
K
K
A
H
K
E
G
T
T
L
K
A
A
A
L
A
L
G
Y
V
T
D
A
Q
F
D
E
W
V
R
P
E
H
M
-------------
16
PsiBlast_PDB
73.52
42%
-13
- C3 -
1FUQ
2
FUMC_ECOLI
A:
[5-459]
--------
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
E
K
M
P
T
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
G
V
R
G
M
E
R
K
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
-
A
L
L
-
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
E
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
----
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
G
Y
L
S
E
A
E
F
D
S
W
V
R
P
E
Q
M
-------------
13
PsiBlast_PDB
73.25
42%
-15
- C3 -
1FUO
2
FUMC_ECOLI
A:
[5-459]
--------
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
E
K
M
P
T
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
G
V
R
G
M
E
R
K
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
-
A
L
L
-
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
E
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
----
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
G
Y
L
S
E
A
E
F
D
S
W
V
R
P
E
Q
M
-------------
12
PsiBlast_PDB
72.27
42%
-12
- C3 -
2FUS
1
FUMC_ECOLI
A:
[5-459]
--------
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
E
K
M
P
T
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
G
V
R
G
M
E
R
K
V
N
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
-
A
L
L
-
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
E
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
----
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
G
Y
L
S
E
A
E
F
D
S
W
V
R
P
E
Q
M
-------------
15
PsiBlast_PDB
71.91
42%
-12
- C3 -
1FUP
2
FUMC_ECOLI
A:
[5-459]
--------
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
E
K
M
P
T
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
G
V
R
G
M
E
R
K
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
-
A
L
L
-
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
E
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
----
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
G
Y
L
S
E
A
E
F
D
S
W
V
R
P
E
Q
M
-------------
11
PsiBlast_PDB
71.83
42%
-13
- C3 -
1KQ7
2
FUMC_ECOLI
A:
[5-459]
--------
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
E
K
M
P
T
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
G
V
R
G
M
E
R
K
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
-
A
L
L
-
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
Q
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
----
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
G
Y
L
S
E
A
E
F
D
S
W
V
R
P
E
Q
M
-------------
47
PsiBlast_CBE
71.58
42%
-15
- C3 -
1FUP
2
FUMC_ECOLI
B:
[5-459]
--------
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
E
K
M
P
T
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
G
V
R
G
M
E
R
K
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
-
A
L
L
-
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
E
P
----
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
----
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
G
Y
L
S
E
A
E
F
D
S
W
V
R
P
E
Q
M
-------------
46
PsiBlast_CBE
70.82
42%
-12
- C3 -
1FUQ
2
FUMC_ECOLI
B:
[5-459]
--------
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
E
K
M
P
T
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
G
V
R
G
M
E
R
K
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
-
A
L
L
-
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
E
P
----
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
----
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
G
Y
L
S
E
A
E
F
D
S
W
V
R
P
E
Q
M
-------------
45
PsiBlast_CBE
70.52
42%
-17
- C3 -
1FUO
2
FUMC_ECOLI
B:
[5-459]
--------
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
E
K
M
P
T
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
G
V
R
G
M
E
R
K
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
-
A
L
L
-
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
E
P
----
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
----
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
G
Y
L
S
E
A
E
F
D
S
W
V
R
P
E
Q
M
-------------
44
PsiBlast_CBE
70.25
42%
-15
- C3 -
2FUS
1
FUMC_ECOLI
B:
[5-459]
--------
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
E
K
M
P
T
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
G
V
R
G
M
E
R
K
V
N
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
-
A
L
L
-
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
E
P
----
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
----
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
G
Y
L
S
E
A
E
F
D
S
W
V
R
P
E
Q
M
-------------
43
PsiBlast_CBE
70.19
42%
-15
- C3 -
1KQ7
1
FUMC_ECOLI
B:
[5-459]
--------
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
E
K
M
P
T
S
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
G
V
R
G
M
E
R
K
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
-
A
L
L
-
A
L
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
-
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
Q
P
----
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
G
M
E
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
----
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
G
Y
L
S
E
A
E
F
D
S
W
V
R
P
E
Q
M
-------------
63
PsiBlast_CBE
65.85
43%
11
- C3 -
3RRP
3
?
A:
[8-468]
----
E
Q
Q
Y
R
I
E
H
D
T
M
G
E
V
R
V
P
A
E
A
L
W
R
A
Q
T
Q
R
A
V
E
N
F
P
I
S
G
R
G
L
E
R
T
Q
I
R
A
L
G
L
L
K
G
A
C
A
Q
V
N
K
D
L
G
L
L
A
A
E
K
A
D
A
I
I
A
A
A
Q
E
I
A
D
G
K
H
D
D
Q
F
P
I
D
V
F
Q
T
G
S
G
T
S
S
N
M
N
A
N
E
V
I
A
S
I
A
A
Q
A
T
-----
P
P
V
V
V
H
P
N
D
D
V
N
M
S
Q
S
S
N
D
T
F
P
T
A
T
H
L
A
A
T
E
A
-
A
V
R
D
-
L
I
P
A
L
E
Y
L
Q
Q
A
L
A
T
K
A
K
A
W
K
T
V
V
K
S
G
R
T
H
L
M
D
A
V
P
V
T
L
G
Q
E
F
G
G
Y
A
R
Q
I
E
A
G
I
E
R
V
K
A
T
L
P
R
L
G
E
L
P
I
G
G
T
A
V
G
T
G
L
N
A
P
D
G
F
G
A
K
V
V
E
V
L
K
Q
S
T
G
L
S
E
L
K
T
A
S
D
S
F
E
A
Q
A
A
R
D
G
L
V
E
G
S
G
A
L
K
T
I
A
A
S
L
T
K
I
A
N
D
I
R
W
M
G
S
G
P
L
T
G
L
G
E
I
Q
L
P
D
L
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
L
P
E
A
V
T
Q
V
A
A
Q
V
I
G
N
D
A
A
I
T
V
G
G
L
S
G
A
F
E
L
N
V
Y
I
P
V
M
A
R
N
L
L
E
S
F
T
L
L
A
N
V
S
R
L
F
V
D
K
C
V
D
G
L
V
A
N
E
D
H
L
R
T
L
A
E
S
S
P
S
I
V
T
P
L
N
S
A
I
G
Y
E
E
A
A
A
V
A
K
E
A
L
K
E
R
K
T
I
R
Q
T
V
I
D
R
G
L
I
G
D
K
L
S
I
E
E
L
D
K
R
L
D
V
L
A
M
A
K
-----------
62
PsiBlast_CBE
64.99
43%
14
- C3 -
3RRP
4
?
B:
[10-468]
------
Q
Y
R
I
E
H
D
T
M
G
E
V
R
V
P
A
E
A
L
W
R
A
Q
T
Q
R
A
V
E
N
F
P
I
S
G
R
G
L
E
R
T
Q
I
R
A
L
G
L
L
K
G
A
C
A
Q
V
N
K
D
L
G
L
L
A
A
E
K
A
D
A
I
I
A
A
A
Q
E
I
A
D
G
K
H
D
D
Q
F
P
I
D
V
F
Q
T
G
S
G
T
S
S
N
M
N
A
N
E
V
I
A
S
I
A
A
Q
A
T
-----
P
P
V
V
V
H
P
N
D
D
V
N
M
S
Q
S
S
N
D
T
F
P
T
A
T
H
L
A
A
T
E
A
-
A
V
R
D
-
L
I
P
A
L
E
Y
L
Q
Q
A
L
A
T
K
A
K
A
W
K
T
V
V
K
S
G
R
T
H
L
M
D
A
V
P
V
T
L
G
Q
E
F
G
G
Y
A
R
Q
I
E
A
G
I
E
R
V
K
A
T
L
P
R
L
G
E
L
P
I
G
G
T
A
V
G
T
G
L
N
A
P
D
G
F
G
A
K
V
V
E
V
L
K
Q
S
T
G
L
S
E
L
K
T
A
S
D
S
F
E
A
Q
A
A
R
D
G
L
V
E
G
S
G
A
L
K
T
I
A
A
S
L
T
K
I
A
N
D
I
R
W
M
G
S
G
P
L
T
G
L
G
E
I
Q
L
P
D
L
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
L
P
E
A
V
T
Q
V
A
A
Q
V
I
G
N
D
A
A
I
T
V
G
G
L
S
G
A
F
E
L
N
V
Y
I
P
V
M
A
R
N
L
L
E
S
F
T
L
L
A
N
V
S
R
L
F
V
D
K
C
V
D
G
L
V
A
N
E
D
H
L
R
T
L
A
E
S
S
P
S
I
V
T
P
L
N
S
A
I
G
Y
E
E
A
A
A
V
A
K
E
A
L
K
E
R
K
T
I
R
Q
T
V
I
D
R
G
L
I
G
D
K
L
S
I
E
E
L
D
K
R
L
D
V
L
A
M
A
K
-----------