@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu23620: (2016-07-06 )
MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINYLDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVKKSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYVKKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQNGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENIQAANARRLTEEEIKALQSHTKQDIYKAHRS
Atome Classification :
(20 SA)
.........10........20-...---..-------...30.---.......40........50--..-------......60.....----.----..70.......-.80..--..--.---...90........100.......110.......120....-----------------....130.......140.......150.---....---..160----.------.......170-........180--........190.......200.......210.--.-.....----220..---.---.---...230..----......240--.-----..--......250.......260.......270.......280.......290.......300....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRKRKLGTSDL
D
I
S
E
VG
L
G
C
M
-SLG---TE-------K
N
K
A
L
S
---
I
L
D
E
A
I
E
LGINYLD
T
A
D
L
Y--DR-------GRN
E
E
I
V
G
D
A
I
QN----R----RH
D
I
I
L
A
TKAG-NRWDD--GS--E---G
W
Y
WD
P
S
K
A
Y
I
K
E
A
V
K
K
S
L
T
R
L
K
T
D
Y
I
D
L
Y
Q
LHG-GTIE
D
-----------------
N
I
D
E
T
I
E
A
F
E
E
L
K
Q
EG
V
I
R
Y
YGISSI
R
P
---
N
V
I
K
---
E
Y
V
K
-----K------
S
N
I
V
S
I
M
M
Q
--
F
S
L
FDR
R
P
E
-
E
--
W
L
P
L
L
E
EH
Q
I
S
V
V
ARGPVAKGLLTEK
P
L
D
Q
A
S
--
E
-
S
M
K
QN----G
Y
L
S
Y
---
S
---
F
---
E
E
L
T
-
N
A
R
----
K
A
M
E
E
VA----P-----D
L
--
S
M
T
E
K
S
L
Q
Y
L
LAQ
P
A
V
A
S
V
IT
G
A
S
K
I
E
Q
L
R
E
N
I
Q
AA
N
A
RRL
T
E
E
E
I
K
A
L
Q
S
H
T
K
Q
D
I
Y
K
A
HRS
2
PsiBlast_PDB
96.42
63%
-109
- C3 -
1YNQ
12
?
A:
[21-316]
M
K
K
R
Q
L
G
T
S
D
L
H
V
S
E
L
G
F
G
C
M
-
S
L
G
---
T
D
-------
E
T
K
A
R
R
---
I
M
D
E
V
L
E
L
G
I
N
Y
L
D
T
A
D
L
Y
--
N
Q
-------
G
L
N
E
Q
F
V
G
K
A
L
K
G
----
R
----
R
Q
D
I
I
L
A
T
K
V
------------------
W
W
W
D
P
S
K
A
Y
I
K
E
A
V
K
D
S
L
R
R
L
Q
T
D
Y
I
D
L
Y
Q
L
H
G
-
G
T
I
D
D
-----------------
P
I
D
E
T
I
E
A
F
E
E
L
K
Q
E
G
V
I
R
Y
Y
G
I
S
S
I
R
P
---
N
V
I
K
---
E
Y
L
K
-----
R
------
S
N
I
V
S
I
M
M
Q
--
Y
S
I
L
D
R
R
P
E
-
E
--
W
F
P
L
I
Q
E
H
G
V
S
V
V
V
R
G
P
V
A
R
G
L
L
S
R
R
P
L
P
E
G
---------
E
----
G
Y
L
N
Y
---
R
---
Y
---
D
E
L
K
-
L
L
R
-------
E
S
L
P
----
T
-----
D
R
--
P
L
H
E
L
A
L
Q
Y
C
L
A
H
D
V
V
A
T
V
A
A
G
A
S
S
I
D
Q
V
K
A
N
V
Q
A
V
E
A
T
P
L
T
A
E
E
R
Q
H
I
Q
K
L
A
K
A
A
V
Y
E
Q
H
R
-
21
PsiBlast_CBE
96.27
63%
-96
- C3 -
1YNQ
10
?
B:
[21-316]
M
K
K
R
Q
L
G
T
S
D
L
H
V
S
E
L
G
F
G
C
M
-
S
L
G
---
T
D
-------
E
T
K
A
R
R
---
I
M
D
E
V
L
E
L
G
I
N
Y
L
D
T
A
D
L
Y
--
N
Q
-------
G
L
N
E
Q
F
V
G
K
A
L
K
G
----
R
----
R
Q
D
I
I
L
A
T
K
V
G
-
N
R
F
E
Q
--
G
K
--
E
---
G
W
W
W
D
P
S
K
A
Y
I
K
E
A
V
K
D
S
L
R
R
L
Q
T
D
Y
I
D
L
Y
Q
L
H
G
-
G
T
I
D
D
-----------------
P
I
D
E
T
I
E
A
F
E
E
L
K
Q
E
G
V
I
R
Y
Y
G
I
S
S
I
R
P
---
N
V
I
K
---
E
Y
L
K
-----
R
------
S
N
I
V
S
I
M
M
Q
--
Y
S
I
L
D
R
R
P
E
-
E
--
W
F
P
L
I
Q
E
H
G
V
S
V
V
V
R
G
P
V
A
R
G
L
L
S
R
R
P
L
P
E
G
---------
E
----
G
Y
L
N
Y
---
R
---
Y
---
D
E
L
K
-
L
L
R
-------
E
S
L
P
----
T
-----
D
R
--
P
L
H
E
L
A
L
Q
Y
C
L
A
H
D
V
V
A
T
V
A
A
G
A
S
S
I
D
Q
V
K
A
N
V
Q
A
V
E
A
T
P
L
T
A
E
E
R
Q
H
I
Q
K
L
A
K
A
A
V
Y
E
Q
H
R
-
22
PsiBlast_CBE
95.47
63%
-95
- C3 -
1YNP
6
?
B:
[21-316]
M
K
K
R
Q
L
G
T
S
D
L
H
V
S
E
L
G
F
G
C
M
-
S
L
G
---
T
D
-------
E
T
K
A
R
R
---
I
M
D
E
V
L
E
L
G
I
N
Y
L
D
T
A
D
L
Y
--
N
Q
-------
G
L
N
E
Q
F
V
G
K
A
L
K
G
----
R
----
R
Q
D
I
I
L
A
T
K
V
G
-
N
R
F
E
Q
--
G
K
--
E
---
G
W
W
W
D
P
S
K
A
Y
I
K
E
A
V
K
D
S
L
R
R
L
Q
T
D
Y
I
D
L
Y
Q
L
H
G
-
G
T
I
D
D
-----------------
P
I
D
E
T
I
E
A
F
E
E
L
K
Q
E
G
V
I
R
Y
Y
G
I
S
S
I
R
P
---
N
V
I
K
---
E
Y
L
K
-----
R
------
S
N
I
V
S
I
M
M
Q
--
Y
S
I
L
D
R
R
P
E
-
E
--
W
F
P
L
I
Q
E
H
G
V
S
V
V
V
R
G
P
V
A
R
G
L
L
S
R
R
P
L
P
E
G
---------
E
----
G
Y
L
N
Y
---
R
---
Y
---
D
E
L
K
-
L
L
R
-------
E
S
L
P
----
T
-----
D
R
--
P
L
H
E
L
A
L
Q
Y
C
L
A
H
D
V
V
A
T
V
A
A
G
A
S
S
I
D
Q
V
K
A
N
V
Q
A
V
E
A
T
P
L
T
A
E
E
R
Q
H
I
Q
K
L
A
K
A
A
V
Y
E
Q
H
R
-
1
PsiBlast_PDB
94.25
63%
-116
- C3 -
1YNP
13
?
A:
[21-316]
M
K
K
R
Q
L
G
T
S
D
L
H
V
S
E
L
G
F
G
C
M
-
S
L
G
---
T
D
-------
E
T
K
A
R
R
---
I
M
D
E
V
L
E
L
G
I
N
Y
L
D
T
A
D
L
Y
--
N
Q
-------
G
L
N
E
Q
F
V
G
K
A
L
K
G
----
R
----
R
Q
D
I
I
L
A
T
K
V
-----------------------
S
K
A
Y
I
K
E
A
V
K
D
S
L
R
R
L
Q
T
D
Y
I
D
L
Y
Q
L
H
G
-
G
T
I
D
D
-----------------
P
I
D
E
T
I
E
A
F
E
E
L
K
Q
E
G
V
I
R
Y
Y
G
I
S
S
I
R
P
---
N
V
I
K
---
E
Y
L
K
-----
R
------
S
N
I
V
S
I
M
M
Q
--
Y
S
I
L
D
R
R
P
E
-
E
--
W
F
P
L
I
Q
E
H
G
V
S
V
V
V
R
G
P
V
A
R
G
L
L
S
R
R
P
L
P
E
G
---------
E
----
G
Y
L
N
Y
---
R
---
Y
---
D
E
L
K
-
L
L
R
-------
E
S
L
P
----
T
-----
D
R
--
P
L
H
E
L
A
L
Q
Y
C
L
A
H
D
V
V
A
T
V
A
A
G
A
S
S
I
D
Q
V
K
A
N
V
Q
A
V
E
A
T
P
L
T
A
E
E
R
Q
H
I
Q
K
L
A
K
A
A
V
Y
E
Q
H
R
-
43
HHSearch
87.38
64%
-89
- C3 -
1YNP
13
?
A:
[21-317]
M
K
K
R
Q
L
G
T
S
D
L
H
V
S
E
L
G
F
G
C
M
-
S
L
G
---
T
D
-------
E
T
K
A
R
R
---
I
M
D
E
V
L
E
L
G
I
N
Y
L
D
T
A
D
L
Y
--
N
Q
-------
G
L
N
E
Q
F
V
G
K
A
L
K
G
----
R
----
R
Q
D
I
I
L
A
T
K
V
-----------------------
S
K
A
Y
I
K
E
A
V
K
D
S
L
R
R
L
Q
T
D
Y
I
D
L
Y
Q
L
H
G
-
G
T
I
D
D
-----------------
P
I
D
E
T
I
E
A
F
E
E
L
K
Q
E
G
V
I
R
Y
Y
G
I
S
S
I
R
P
---
N
V
I
K
---
E
Y
L
K
-----
R
------
S
N
I
V
S
I
M
M
Q
--
Y
S
I
L
D
R
R
P
E
-
E
--
W
F
P
L
I
Q
E
H
G
V
S
V
V
V
R
G
P
V
A
R
G
L
L
S
R
R
P
L
P
E
G
E
-----------------------------
G
Y
L
N
-
Y
R
Y
----
D
E
L
K
L
L
R
E
S
LP
T
-----
D
R
--
P
L
H
E
L
A
L
Q
Y
C
L
A
H
D
V
V
A
T
V
A
A
G
A
S
S
I
D
Q
V
K
A
N
V
Q
A
V
E
A
T
P
L
T
A
E
E
R
Q
H
I
Q
K
L
A
K
A
A
V
Y
E
Q
H
R
E
52
HHSearch
59.09
29%
32
- C3 -
3N6Q
1
GPR_ECOLI
A:
[13-336]
M
Q
Y
R
Y
C
G
K
S
G
L
R
L
P
A
L
S
L
G
L
W
-
H
N
F
---
G
H
VNA----
L
E
S
Q
R
A
---
I
L
R
K
A
F
D
L
G
I
T
H
F
D
L
A
N
N
Y
--
G
P
PP-----
G
S
A
E
E
N
F
G
R
L
L
R
E
DFAA
Y
----
R
D
E
L
I
I
S
T
K
A
G
-
Y
D
M
W
P
------
G
---
P
Y
G
S
G
G
S
R
K
Y
L
L
A
S
L
D
Q
S
L
K
R
M
G
L
E
Y
V
D
I
F
Y
S
H
R
-
V
D
E
N
T
-----------------
P
M
E
E
T
A
S
A
L
A
H
A
V
Q
S
G
K
A
L
Y
V
G
I
S
S
Y
S
P
---
E
R
T
Q
---
K
M
V
E
L
L
R
E
W
K
------
I
P
L
L
I
H
Q
P
S
--
Y
N
L
L
N
R
W
V
D
K
S
G-
L
L
D
T
L
Q
N
N
G
V
G
C
I
A
F
T
P
L
A
Q
G
L
L
T
G
K
Y
L
-------------------------
L
---
T
---
E
A
N
L
-
N
S
L
----
R
L
L
N
E
M
A
Q
Q
--
R
-----
G
Q
--
S
M
A
Q
M
A
L
S
W
L
L
K
D
D
R
V
T
S
V
L
I
G
A
S
R
A
E
Q
L
E
E
N
V
Q
A
L
N
N
L
T
F
S
T
K
E
L
A
Q
I
D
Q
H
I
A
D
G
E
------
57
HHSearch
59.07
28%
4
- C3 -
4WGH
2
?
A:
[25-301]
K
K
T
V
R
F
G
E
-
Q
A
A
V
P
A
I
G
L
G
T
W
-
Y
M
G
---
E
H
AAQ----
R
Q
Q
E
V
A
---
A
L
R
A
G
I
D
H
G
L
T
V
I
D
T
A
E
M
Y
--
A
D
-------
G
G
A
E
E
V
V
G
Q
A
I
R
G
----
L
----
R
D
R
V
V
L
V
S
K
V
Y
-
P
W
-----------------
H
A
G
K
A
A
M
H
R
A
C
E
N
S
L
R
R
L
Q
T
D
Y
L
D
M
Y
L
L
H
W
-
R
G
D
I
------------------
P
L
Q
E
T
V
E
A
M
E
K
L
V
A
E
G
K
I
R
R
W
G
V
S
N
L
D
T
---
E
D
M
Q
---
A
L
W
R
TAD--
G
------
E
H
C
A
T
N
Q
V
L
--
Y
H
L
A
S
R
G
I
E
-
Y
D-
L
L
P
W
C
Q
Q
H
S
L
P
V
M
A
Y
C
P
L
A
Q
A
G
R
L
R
D
G
L
F
--------------------------------
Q
------
H
----
S
D
I
I
N
M
A
N
A
--
R
-----
G
I
--
T
V
A
Q
L
L
L
A
W
V
I
R
H
P
G
V
L
-
A
I
P
K
A
A
S
I
E
H
V
V
Q
N
A
A
A
L
D
-
I
V
L
S
G
E
E
L
A
Q
L
D
R
L
Y
P
P
P
Q
R
K
N
---
45
HHSearch
58.92
30%
59
- C3 -
1LQA
1
TAS_ECOLI
A:
[1-345]
M
Q
Y
H
R
I
P
H
S
S
L
E
V
S
T
L
G
L
G
T
M
-
T
F
G
---
E
Q
NS-----
E
A
D
A
H
A
---
Q
L
D
Y
A
V
A
Q
G
I
N
L
I
D
V
A
E
M
Y
--
P
V
PPRPETQ
G
L
T
E
T
Y
V
G
N
W
L
A
K
----
H
GS--
R
E
K
L
I
I
A
S
K
V
S
-
G
P
S
R
N
--
N
D
KG
I
---
R
P
D
Q
A
L
D
R
K
N
I
R
E
A
L
H
D
S
L
K
R
L
Q
T
D
Y
L
D
L
Y
Q
V
H
W
-
P
Q
R
P
T
NCFGKL
G
Y
S
W
T
DSAPAV
S
L
L
D
T
L
D
A
L
A
E
Y
Q
R
A
G
K
I
R
Y
I
G
V
S
N
E
T
A
---
F
G
V
M
---
R
Y
L
H
-----
L
A
D
K
H
DL
P
R
I
V
T
I
Q
N
P
--
Y
S
L
L
N
R
S
F
E
-
V
G-
L
A
E
V
S
Q
Y
E
G
V
E
L
L
A
Y
S
C
L
G
F
G
T
L
T
G
K
Y
L
N
G
A
K
--
P
-
A
G
A
R
N
T
L
F
S
R
F
T
R
Y
---
S
---
G
---
E
Q
T
Q
-
K
A
V
----
A
A
Y
V
D
I
A
R
R
--
H
-----
G
L
--
D
P
A
Q
M
A
L
A
F
V
R
R
Q
P
F
V
A
S
T
L
L
G
A
T
T
M
D
Q
L
K
T
N
I
E
S
L
H
-
L
E
L
S
E
D
V
L
A
E
I
E
A
V
H
Q
V
Y
T
Y
P
A
---
50
HHSearch
58.74
32%
50
- C3 -
1PYF
3
IOLS_BACSU
A:
[2-311]
-
K
K
A
K
L
G
K
S
D
L
Q
V
F
P
I
G
L
G
T
N
-
A
V
G
---
G
H
NLYPNLN
E
E
T
G
K
E
---
L
V
R
E
A
I
R
N
G
V
T
M
L
D
T
A
Y
I
Y
--
G
I
-------
G
R
S
E
E
L
I
G
E
V
L
R
E
----
F
N---
R
E
D
V
V
I
A
T
K
A
A
-
H
R
K
Q
G
--
N
-------
D
F
V
F
D
N
S
P
D
F
L
K
K
S
V
D
E
S
L
K
R
L
N
T
D
Y
I
D
L
F
Y
I
H
F
-
P
D
E
H
T
-----------------
P
K
D
E
A
V
N
A
L
N
E
M
K
K
A
G
K
I
R
S
I
G
V
S
N
F
S
L
---
E
Q
L
K
---
E
A
N
K
-----
D
------
G
L
V
D
V
L
Q
G
E
--
Y
N
L
L
N
R
E
A
E
-
K
T-
F
F
P
Y
T
K
E
H
N
I
S
F
I
P
Y
F
P
L
V
S
G
L
L
A
G
K
Y
T
E
D
T
T
F
P
E
-
G
D
L
R
N
----
E
Q
E
H
F
---
K
G
E
R
F
---
K
E
N
I
-
R
K
V
----
N
K
L
A
P
I
A
E
K
--
H
-----
N
V
--
D
I
P
H
I
V
L
A
W
Y
L
A
R
P
E
I
D
I
L
I
P
G
A
K
R
A
D
Q
L
I
D
N
I
K
T
A
D
-
V
T
L
S
Q
E
D
I
S
F
I
D
K
L
F
A
P
--------
54
HHSearch
58.12
26%
33
- C3 -
3ERP
17
?
A:
[34-351]
M
E
Y
R
R
C
G
R
S
G
V
K
L
P
A
I
S
L
G
L
W
-
H
N
F
---
G
D
TTR----
V
E
N
S
R
A
---
L
L
Q
R
A
F
D
L
G
I
T
H
F
D
L
A
N
N
Y
--
G
P
PP-----
G
S
A
E
C
N
F
G
R
I
L
Q
E
DFLP
W
----
R
D
E
L
I
I
S
T
K
A
G
-
Y
T
M
W
D
------
G
---
P
Y
G
D
W
G
S
R
K
Y
L
I
A
S
L
D
Q
S
L
K
R
M
G
L
E
Y
V
D
I
F
Y
H
H
R
-
P
D
P
E
T
-----------------
P
L
K
E
T
M
K
A
L
D
H
L
V
R
H
G
K
A
L
Y
V
G
I
S
N
Y
P
A
---
D
L
A
R
---
Q
A
I
D
-----
I
L
E
D
L
G-
T
P
C
L
I
H
Q
P
K
--
Y
S
L
F
E
R
W
V
E
-
D
G-
L
L
A
L
L
Q
E
K
G
V
G
S
I
A
F
S
P
L
A
G
G
Q
L
T
D
R
Y
L
N
------------------------
I
---
T
---
A
D
K
L
-
E
K
V
----
R
R
L
N
E
L
A
A
R
--
R
-----
G
Q
--
K
L
S
Q
M
A
L
A
W
V
L
R
N
D
N
V
T
S
V
L
I
G
A
S
K
P
S
Q
I
E
D
A
V
G
M
L
A
N
R
R
F
S
A
A
E
C
A
E
I
D
A
I
L
E
G
--------
4
PsiBlast_PDB
57.73
30%
61
- C3 -
1PZ0
2
IOLS_BACSU
A:
[2-302]
-
K
K
A
K
L
G
K
S
D
L
Q
V
F
P
I
G
L
G
T
N
-
A
V
G
---
G
H
NLYPNLN
E
E
T
G
K
E
---
L
V
R
E
A
I
R
N
G
V
T
M
L
D
T
A
Y
I
Y
--
G
I
-------
G
R
S
E
E
L
I
G
E
V
L
R
E
F
---
N
----
R
E
D
V
V
I
A
T
K
A
A
-
H
R
-
K
Q
--
G
N
--
D
----
F
V
F
D
N
S
P
D
F
L
K
K
S
V
D
E
S
L
K
R
L
N
T
D
Y
I
D
L
F
Y
I
H
F
-
P
D
E
H
T
-----------------
P
K
D
E
A
V
N
A
L
N
E
M
K
K
A
G
K
I
R
S
I
G
V
S
N
F
S
L
---
E
Q
L
K
---
E
A
N
K
-----
D
------
G
L
V
D
V
L
Q
G
E
--
Y
N
L
L
N
R
E
A
E
-
K
T-
F
F
P
Y
T
K
E
H
N
I
S
F
I
P
Y
F
P
L
V
S
G
L
L
A
G
K
Y
T
E
D
T
T
F
P
E
-
G
D
L
R
N
----
E
Q
E
H
F
---
K
---
G
---
E
R
F
K
-
E
N
I
----
R
K
V
N
K
L
A
----
P
I
A
E
K
H
N
V
--
D
I
P
H
I
V
L
A
W
Y
L
A
R
P
E
I
D
I
L
I
P
G
A
K
R
A
D
Q
L
I
D
N
I
K
T
A
D
V
-
T
L
S
Q
E
D
I
-----------------
3
PsiBlast_PDB
57.31
30%
61
- C3 -
1PYF
2
IOLS_BACSU
A:
[2-302]
-
K
K
A
K
L
G
K
S
D
L
Q
V
F
P
I
G
L
G
T
N
-
A
V
G
---
G
H
NLYPNLN
E
E
T
G
K
E
---
L
V
R
E
A
I
R
N
G
V
T
M
L
D
T
A
Y
I
Y
--
G
I
-------
G
R
S
E
E
L
I
G
E
V
L
R
E
F
---
N
----
R
E
D
V
V
I
A
T
K
A
A
-
H
R
-
K
Q
--
G
N
--
D
----
F
V
F
D
N
S
P
D
F
L
K
K
S
V
D
E
S
L
K
R
L
N
T
D
Y
I
D
L
F
Y
I
H
F
-
P
D
E
H
T
-----------------
P
K
D
E
A
V
N
A
L
N
E
M
K
K
A
G
K
I
R
S
I
G
V
S
N
F
S
L
---
E
Q
L
K
---
E
A
N
K
-----
D
------
G
L
V
D
V
L
Q
G
E
--
Y
N
L
L
N
R
E
A
E
-
K
T-
F
F
P
Y
T
K
E
H
N
I
S
F
I
P
Y
F
P
L
V
S
G
L
L
A
G
K
Y
T
E
D
T
T
F
P
E
-
G
D
L
R
N
----
E
Q
E
H
F
---
K
---
G
---
E
R
F
K
-
E
N
I
----
R
K
V
N
K
L
A
----
P
I
A
E
K
H
N
V
--
D
I
P
H
I
V
L
A
W
Y
L
A
R
P
E
I
D
I
L
I
P
G
A
K
R
A
D
Q
L
I
D
N
I
K
T
A
D
V
-
T
L
S
Q
E
D
I
-----------------
12
PsiBlast_PDB
56.42
27%
-8
- C3 -
4WGH
2
?
A:
[36-277]
------------
V
P
A
I
G
L
G
T
W
-
Y
M
G
EHA
A
Q
-------
R
Q
Q
E
V
A
---
A
L
R
A
G
I
D
H
G
L
T
V
I
D
T
A
E
M
Y
--
A
D
-------
G
G
A
E
E
V
V
G
Q
A
I
R
G
----
L
----
R
D
R
V
V
L
V
S
K
V
------------------
Y
P
W
H
A
G
K
A
A
M
H
R
A
C
E
N
S
L
R
R
L
Q
T
D
Y
L
D
M
Y
L
L
H
W
R
G
D
I
P
-------------------
L
Q
E
T
V
E
A
M
E
K
L
V
A
E
G
K
I
R
R
W
G
V
S
N
L
D
T
E
D
M
Q
A
L
W
---
R
T
A
D
-----
G
------
E
H
C
A
T
N
Q
V
L
--
Y
H
L
A
S
R
G
I
E
Y
D
--
L
L
P
W
C
Q
Q
H
S
L
P
V
M
A
Y
C
P
L
A
Q
A
G
R
L
R
D
G
L
F
Q
H
S
--
D
-
I
I
N
M
------------------------
A
-
N
A
R
---------------------
G
I
--
T
V
A
Q
L
L
L
A
W
V
I
R
H
P
G
V
L
A
I
P
K
A
A
S
-
I
E
H
V
V
Q
N
A
A
A
----------------------------
56
HHSearch
55.91
28%
22
- C3 -
5C7H
1
?
A:
[5-275]
I
P
T
I
A
F
P
-
D
G
R
K
V
P
A
L
G
Q
G
T
W
-
R
M
G
---
E
N
RAK----
T
A
D
E
V
R
---
S
L
Q
T
G
L
D
L
G
M
T
L
I
D
T
A
E
M
Y
--
G
D
-------
G
A
A
E
R
I
V
G
E
A
I
K
G
----
R
----
R
D
E
A
F
V
V
S
K
V
L
-
P
S
-----------------
N
A
S
R
A
G
T
V
A
A
C
E
R
S
L
R
N
L
G
I
D
C
V
D
L
Y
L
L
H
W
-
R
G
G
Y
------------------
P
L
A
E
T
V
A
A
F
E
E
L
K
K
A
G
K
I
R
A
W
G
V
S
N
F
D
V
---
D
D
M
E
---
E
L
S
A
V
PD--
G
------
G
N
V
A
A
N
Q
V
L
--
Y
N
L
A
R
R
G
I
E
-
F
D-
L
L
P
R
C
R
A
Q
G
V
P
V
M
A
Y
S
P
L
D
E
G
R
L
L
H
D
A
-----------------------------------------------
D
L
I
H
I
A
K
A
--
H
-----
Q
A
--
T
P
A
Q
V
A
L
A
F
L
K
T
C
S
G
V
-
I
S
I
P
K
T
G
S
P
E
R
A
R
E
N
R
D
A
M
D
-
I
H
L
T
T
E
N
L
A
E
L
D
R
H
F
P
P
P
R
R
K
----
49
HHSearch
55.00
29%
57
- C3 -
3N2T
-
?
A:
[3-316]
S
D
T
I
R
I
P
G
I
D
T
P
L
S
R
V
A
L
G
T
W
-
A
I
G
---
G
W
MWGGPD-
D
D
N
G
V
R
---
T
I
H
A
A
L
D
E
G
I
N
L
I
D
T
A
P
V
Y
--
G
F
-------
G
H
S
E
E
I
V
G
R
A
L
A
E
----
K
----
P
N
K
A
H
V
A
T
K
L
G
-
L
H
W
V
G
--
E
D
--
E
KN
M
K
V
F
R
D
S
R
P
A
R
I
R
K
E
V
E
D
S
L
R
R
L
R
V
E
T
I
D
L
E
Q
I
H
W
-
P
D
D
K
T
-----------------
P
I
D
E
S
A
R
E
L
Q
K
L
H
Q
D
G
K
I
R
A
L
G
V
S
N
F
S
P
---
E
Q
M
D
---
I
F
R
E
-----
V
------
A
P
L
A
T
I
Q
P
P
--
L
N
L
F
E
R
T
I
E
-
K
D-
I
L
P
Y
A
E
K
H
N
A
V
V
L
A
Y
G
A
L
C
R
G
L
L
T
G
K
M
N
R
D
T
T
F
P
K
-
D
D
L
R
S
----
N
D
P
K
F
QK
P
N
---
F
---
E
K
Y
L
-
A
A
M
----
D
E
F
E
K
L
A
E
K
--
R
-----
G
K
--
S
V
M
A
F
A
V
R
W
V
L
D
Q
G
P
V
-
I
A
L
W
G
A
R
K
P
G
Q
V
S
G
V
K
D
V
F
G
-
W
S
L
T
D
E
E
K
K
A
V
D
D
I
L
A
R
H
-------
58
HHSearch
54.95
26%
-3
- C3 -
4Q3M
1
?
A:
[2-264]
-
H
S
V
K
L
N
N
-
N
Y
E
M
P
I
I
G
L
G
T
F
-
R
S
K
------------
K
N
D
A
Y
N
---
A
V
K
A
A
L
E
G
G
Y
R
H
I
D
T
A
M
I
Y
--
G
N
----------
E
E
E
V
G
R
A
I
K
D
----
S
NIP-
R
E
E
I
F
V
T
T
K
L
W
-
N
T
-----------------
D
Q
G
Y
E
K
T
L
E
A
F
N
T
S
L
K
N
L
G
L
D
Y
I
D
L
Y
L
I
H
W
-
F
K
G
Y
D
-----------------
N
A
L
S
T
Y
R
A
F
E
T
L
Y
E
E
G
K
V
K
A
I
G
V
S
N
F
N
V
---
H
H
L
M
---
Y
L
M
E
-----
N
AK----
I
P
P
M
V
N
Q
V
E
--
T
H
V
T
L
Q
N
H
--
F
--
L
H
D
Y
C
K
K
N
N
I
Q
L
E
A
Y
A
P
L
M
S
H
Q
I
K
D
L
L
S
----------------------------------------
N
----
E
T
M
A
K
I
A
K
K
--
H
-----
D
K
--
T
I
P
Q
I
A
I
R
W
L
I
E
R
E
I
--
V
V
I
P
K
S
I
T
P
E
R
I
V
Q
N
F
D
V
F
D
-
F
T
L
D
E
E
D
M
K
S
I
R
S
V
N
T
G
K
K
------
11
PsiBlast_PDB
54.75
26%
61
- C3 -
3ERP
16
?
A:
[34-342]
M
E
Y
R
R
C
G
R
S
G
V
K
L
P
A
I
S
L
G
L
W
H
N
F
G
DT-
T
R
-------
V
E
N
S
R
A
---
L
L
Q
R
A
F
D
L
G
I
T
H
F
D
L
A
N
N
Y
GP
P
P
-------
G
S
A
E
C
N
F
G
R
I
L
Q
E
----
D
FLPW
R
D
E
L
I
I
S
T
K
A
G
Y
T
M
W
D
G
--
P
Y
--
G
---
D
W
---
G
S
R
K
Y
L
I
A
S
L
D
Q
S
L
K
R
M
G
L
E
Y
V
D
I
F
Y
H
H
R
-
P
D
P
E
T
-----------------
P
L
K
E
T
M
K
A
L
D
H
L
V
R
H
G
K
A
L
Y
V
G
I
S
N
Y
P
A
---
D
L
A
R
---
Q
A
I
D
I
L
E
D
L
G
------
T
P
C
L
I
H
Q
P
K
--
Y
S
L
F
E
R
W
V
E
-
D
G-
L
L
A
L
L
Q
E
K
G
V
G
S
I
A
F
S
P
L
A
G
G
Q
L
T
D
R
Y
L
N
----------------------------------
I
T
-
A
D
K
L
E
K
V
R
R
L
N
E
L
A
----
A
R
R
---
G
Q
--
K
L
S
Q
M
A
L
A
W
V
L
R
N
D
N
V
T
S
V
L
I
G
A
S
K
P
S
Q
I
E
D
A
V
G
M
L
A
N
R
R
F
S
A
A
E
C
-----------------
48
HHSearch
54.61
30%
61
- C3 -
1PZ1
1
GS69_BACSU
A:
[1-314]
M
E
Y
T
S
I
A
D
T
G
I
E
A
S
R
I
G
L
G
T
W
-
A
I
G
---
G
T
MWGGTD-
E
K
T
S
I
E
---
T
I
R
A
A
L
D
Q
G
I
T
L
I
D
T
A
P
A
Y
--
G
F
-------
G
Q
S
E
E
I
V
G
K
A
I
K
E
----
Y
MK--
R
D
Q
V
I
L
A
T
K
T
A
-
L
D
W
K
N
--
N
-------
Q
L
F
R
H
A
N
R
A
R
I
V
E
E
V
E
N
S
L
K
R
L
Q
T
D
Y
I
D
L
Y
Q
V
H
W
-
P
D
P
L
V
-----------------
P
I
E
E
T
A
E
V
M
K
E
L
Y
D
A
G
K
I
R
A
I
G
V
S
N
F
S
I
---
E
Q
M
D
---
T
F
R
A
-----
V
------
A
P
L
H
T
I
Q
P
P
--
Y
N
L
F
E
R
E
M
E
-
E
S-
V
L
P
Y
A
K
D
N
K
I
T
T
L
L
Y
G
S
L
C
R
G
L
L
T
G
K
M
T
E
E
Y
T
F
-
E
G
D
D
L
R
N
----
H
D
P
K
F
---
Q
---
K
PR
F
K
E
Y
L
-
S
A
V
----
N
Q
L
D
K
L
A
K
T
R
-
Y
-----
G
K
--
S
V
I
H
L
A
V
R
W
I
L
D
Q
P
G
A
D
I
A
L
W
G
A
R
K
P
G
Q
L
E
A
L
S
E
I
T
G
-
W
T
L
N
S
E
D
Q
K
D
I
N
T
I
L
E
N
T
I
------
9
PsiBlast_PDB
54.50
29%
41
- C3 -
3N6Q
1
GPR_ECOLI
A:
[13-331]
M
Q
Y
R
Y
C
G
K
S
G
L
R
L
P
A
L
S
L
G
L
W
-
H
N
F
---
G
H
-------
V
N
A
L
E
S
Q
R
A
I
L
R
K
A
F
D
L
G
I
T
H
F
D
L
A
N
N
Y
--
G
P
PP-----
G
S
A
E
E
N
F
G
R
L
L
R
E
DFAA
Y
----
R
D
E
L
I
I
S
T
K
A
G
Y
D
M
W
P
G
PY
G
S
--
G
---
G
-----
S
R
K
Y
L
L
A
S
L
D
Q
S
L
K
R
M
G
L
E
Y
V
D
I
F
Y
S
H
R
-
V
D
E
N
T
-----------------
P
M
E
E
T
A
S
A
L
A
H
A
V
Q
S
G
K
A
L
Y
V
G
I
S
S
Y
S
P
---
E
R
T
Q
K
M
V
E
L
L
R
-----
E
------
W
K
I
P
L
L
I
H
Q
P
S
Y
N
L
L
N
R
W
V
D
-
K
S
G
L
L
D
T
L
Q
N
N
G
V
G
C
I
A
F
T
P
L
A
Q
G
L
L
T
G
K
Y
L
-----------------------------
L
---
T
E
A
N
L
N
S
L
----
R
L
L
N
E
M
A
----
Q
-----
Q
R
GQ
S
M
A
Q
M
A
L
S
W
L
L
K
D
D
R
V
T
S
V
L
I
G
A
S
R
A
E
Q
L
E
E
N
V
Q
A
L
N
N
L
T
F
S
T
K
E
L
A
Q
I
D
Q
H
-----------
8
PsiBlast_PDB
54.14
29%
45
- C3 -
4AUB
2
GPR_ECOLI
A:
[33-351]
M
Q
Y
R
Y
C
G
K
S
G
L
R
L
P
A
L
S
L
G
L
W
-
H
N
F
---
G
H
-------
V
N
A
L
E
S
Q
R
A
I
L
R
K
A
F
D
L
G
I
T
H
F
D
L
A
N
N
Y
--
G
P
PP-----
G
S
A
E
E
N
F
G
R
L
L
R
E
DFAA
Y
----
R
D
E
L
I
I
S
T
K
A
G
Y
D
M
W
P
G
PY
G
S
--
G
---
G
-----
S
R
K
Y
L
L
A
S
L
D
Q
S
L
K
R
M
G
L
E
Y
V
D
I
F
Y
S
H
R
-
V
D
E
N
T
-----------------
P
M
E
E
T
A
S
A
L
A
H
A
V
Q
S
G
K
A
L
Y
V
G
I
S
S
Y
S
P
---
E
R
T
Q
K
M
V
E
L
L
R
-----
E
------
W
K
I
P
L
L
I
H
Q
P
S
Y
N
L
L
N
R
W
V
D
-
K
S
G
L
L
D
T
L
Q
N
N
G
V
G
C
I
A
F
T
P
L
A
Q
G
L
L
T
G
K
-------------------------------
L
---
T
E
A
N
L
N
S
L
----
R
L
L
N
E
M
A
----
Q
-----
Q
R
GQ
S
M
A
Q
M
A
L
S
W
L
L
K
D
D
R
V
T
S
V
L
I
G
A
S
R
A
E
Q
L
E
E
N
V
Q
A
L
N
N
L
T
F
S
T
K
E
L
A
Q
I
D
Q
H
-----------