@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu23800: (2016-07-07 )
MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIELKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIETIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVEERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSGKQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALERHS
Atome Classification :
(26 SA)
.........10........20........30........40........50........60........70........80......-..90-.........100.......110.......120.......130.......140.......150..-.....160........170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
K
I
GFVG
A
G
S
M
A
E
A
M
I
N
G
I
L
Q
SGITKP
E
H
I
Y
I
TNRSN
D
E
R
L
I
E
L
K
E
TYSVRPCRDKNEFFTHT
D
I
I
I
L
A
FKP
K
D
A
A
E
S
I
D
S
I
R
P
Y
I
-
K
D
Q
--
L
V
I
S
V
L
A
G
L
T
I
E
T
I
Q
H
YFG
R
K
L
A
V
I
R
VMPN
T
S
A
A
I
RKSATG
F
S
V
STEASKN
D
I
I
A
A
K
A
L
L
E
TIG-D
A
T
L
V
E
-
E
RHL
D
A
V
T
AIAGS
G
P
A
Y
V
Y
R
Y
I
E
A
M
E
K
A
A
Q
KVGL
D
K
E
T
A
K
A
L
I
L
Q
T
MAG
A
T
D
M
L
L
QSGK
Q
P
E
K
L
R
K
E
ITSPGG
T
T
E
A
G
L
R
A
L
Q
D
S
R
F
E
E
A
I
I
H
C
I
E
E
T
A
K
R
S
A
E
I
K
E
Q
F
A
GAALERHS
5
PsiBlast_PDB
89.68
31%
-84
- C4 -
3TRI
5
?
A:
[5-268]
--
N
I
T
F
I
G
G
G
N
M
A
R
N
I
V
V
G
L
I
A
N
G
Y
-
D
P
N
R
I
C
V
T
N
R
S
L
D
-
K
L
D
F
F
K
E
K
C
G
V
H
T
T
Q
D
N
R
Q
G
A
L
N
A
D
V
V
V
L
A
V
K
P
H
Q
I
K
M
V
C
E
E
L
K
D
I
L
-
S
E
T
K
I
L
V
I
S
L
A
V
G
V
T
T
P
L
I
E
K
W
L
G
K
A
S
R
I
V
R
A
M
P
N
T
P
S
S
V
R
A
G
A
T
G
L
F
A
N
E
T
V
D
K
D
Q
K
N
L
A
E
S
I
M
R
A
V
G
-
L
V
I
W
V
S
S
E
D
Q
I
E
K
I
A
A
L
S
G
S
G
P
A
Y
I
F
L
I
M
E
A
L
Q
E
A
A
E
Q
L
G
L
T
K
E
T
A
E
L
L
T
E
Q
T
V
L
G
A
A
R
M
A
L
E
T
E
Q
S
V
V
Q
L
R
Q
F
V
T
S
P
G
G
T
T
E
Q
A
I
K
V
L
E
S
G
N
L
R
E
L
F
I
K
A
L
T
A
A
V
N
R
A
K
E
L
-------------
49
PsiBlast_CBE
89.31
33%
-72
- C4 -
5BSE
3
?
I:
[16-276]
---
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
R
T
A
F
-
E
S
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
T
K
D
K
--
L
L
V
S
V
A
A
G
I
K
M
K
D
L
Q
E
W
A
G
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
-------------
48
PsiBlast_CBE
89.12
33%
-73
- C4 -
5BSE
3
?
J:
[16-276]
---
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
R
T
A
F
-
E
S
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
T
K
D
K
--
L
L
V
S
V
A
A
G
I
K
M
K
D
L
Q
E
W
A
G
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
-------------
50
PsiBlast_CBE
89.01
33%
-72
- C4 -
5BSE
2
?
H:
[16-276]
---
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
R
T
A
F
-
E
S
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
T
K
D
K
--
L
L
V
S
V
A
A
G
I
K
M
K
D
L
Q
E
W
A
G
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
-------------
53
PsiBlast_CBE
88.90
33%
-73
- C4 -
5BSE
1
?
E:
[16-276]
---
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
R
T
A
F
-
E
S
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
T
K
D
K
--
L
L
V
S
V
A
A
G
I
K
M
K
D
L
Q
E
W
A
G
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
-------------
22
PsiBlast_CBE
88.88
33%
-76
- C4 -
5BSH
2
?
I:
[16-276]
---
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
R
T
A
F
-
E
S
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
T
K
D
K
--
L
L
V
S
V
A
A
G
I
K
M
K
D
L
Q
E
W
A
G
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
-------------
51
PsiBlast_CBE
88.64
33%
-73
- C4 -
5BSE
2
?
G:
[16-276]
---
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
R
T
A
F
-
E
S
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
T
K
D
K
--
L
L
V
S
V
A
A
G
I
K
M
K
D
L
Q
E
W
A
G
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
-------------
45
PsiBlast_CBE
88.63
33%
-70
- C4 -
5BSF
4
?
D:
[16-276]
---
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
R
T
A
F
-
E
S
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
T
K
D
K
--
L
L
V
S
V
A
A
G
I
K
M
K
D
L
Q
E
W
A
G
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
-------------
44
PsiBlast_CBE
88.56
33%
-72
- C4 -
5BSF
3
?
E:
[16-276]
---
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
R
T
A
F
-
E
S
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
T
K
D
K
--
L
L
V
S
V
A
A
G
I
K
M
K
D
L
Q
E
W
A
G
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
-------------
26
PsiBlast_CBE
88.53
33%
-73
- C4 -
5BSH
2
?
E:
[16-276]
---
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
R
T
A
F
-
E
S
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
T
K
D
K
--
L
L
V
S
V
A
A
G
I
K
M
K
D
L
Q
E
W
A
G
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
-------------
55
PsiBlast_CBE
88.51
33%
-71
- C4 -
5BSE
2
?
C:
[16-276]
---
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
R
T
A
F
-
E
S
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
T
K
D
K
--
L
L
V
S
V
A
A
G
I
K
M
K
D
L
Q
E
W
A
G
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
-------------
21
PsiBlast_CBE
88.39
33%
-76
- C4 -
5BSH
2
?
J:
[16-276]
---
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
R
T
A
F
-
E
S
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
T
K
D
K
--
L
L
V
S
V
A
A
G
I
K
M
K
D
L
Q
E
W
A
G
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
-------------
36
PsiBlast_CBE
88.34
33%
-71
- C4 -
5BSG
4
?
D:
[16-276]
---
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
R
T
A
F
-
E
S
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
T
K
D
K
--
L
L
V
S
V
A
A
G
I
K
M
K
D
L
Q
E
W
A
G
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
-------------
37
PsiBlast_CBE
88.33
33%
-70
- C4 -
5BSG
4
?
C:
[16-276]
---
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
R
T
A
F
-
E
S
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
T
K
D
K
--
L
L
V
S
V
A
A
G
I
K
M
K
D
L
Q
E
W
A
G
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
-------------
35
PsiBlast_CBE
88.15
33%
-73
- C4 -
5BSG
3
?
E:
[16-276]
---
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
R
T
A
F
-
E
S
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
T
K
D
K
--
L
L
V
S
V
A
A
G
I
K
M
K
D
L
Q
E
W
A
G
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
-------------
54
PsiBlast_CBE
88.14
33%
-73
- C4 -
5BSE
2
?
D:
[16-276]
---
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
R
T
A
F
-
E
S
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
T
K
D
K
--
L
L
V
S
V
A
A
G
I
K
M
K
D
L
Q
E
W
A
G
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
-------------
23
PsiBlast_CBE
88.01
33%
-75
- C4 -
5BSH
2
?
H:
[16-276]
---
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
R
T
A
F
-
E
S
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
T
K
D
K
--
L
L
V
S
V
A
A
G
I
K
M
K
D
L
Q
E
W
A
G
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
-------------
28
PsiBlast_CBE
87.99
33%
-76
- C4 -
5BSH
2
?
C:
[16-276]
---
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
I
K
T
A
--
S
N
P
A
R
R
T
A
F
-
E
S
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
T
K
D
K
--
L
L
V
S
V
A
A
G
I
K
M
K
D
L
Q
E
W
A
G
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
-------------
39
PsiBlast_CBE
87.98
33%
-71
- C4 -
5BSF
14
?
J:
[16-276]
---
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
R
T
A
F
-
E
S
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
T
K
D
K
--
L
L
V
S
V
A
A
G
I
K
M
K
D
L
Q
E
W
A
G
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
-------------
3
PsiBlast_PDB
87.96
33%
-71
- C4 -
5BSG
4
?
A:
[16-276]
---
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
I
K
T
A
I
H
S
N
P
A
R
R
T
A
F
-
E
S
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
T
K
D
K
--
L
L
V
S
V
A
A
G
I
K
M
K
D
L
Q
E
W
A
G
H
E
-
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
-
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
-------------
69
PsiBlast_CBE
84.59
31%
-136
- C4 -
2AMF
2
?
E:
[5-256]
--
K
I
G
I
I
G
V
G
K
M
A
S
A
I
I
K
G
L
K
Q
T
-----
P
H
E
L
I
I
S
G
S
S
L
E
R
S
K
E
I
A
E
Q
L
A
L
P
Y
A
M
S
H
Q
D
L
I
D
Q
V
D
L
V
I
L
G
I
K
P
Q
-
L
F
E
T
V
--
L
K
P
L
H
-
F
K
Q
--
P
I
I
S
M
A
A
G
I
S
L
Q
R
L
A
T
F
V
G
Q
D
L
P
L
L
R
I
M
P
N
M
N
A
Q
I
L
Q
S
S
T
A
L
T
G
N
A
L
V
S
Q
E
L
Q
A
R
V
R
D
L
T
D
S
F
G
-
S
T
F
D
I
S
-
E
K
D
F
D
T
F
T
A
L
A
G
S
S
P
A
Y
I
Y
L
F
I
E
A
L
A
K
A
G
V
K
N
G
I
P
K
A
K
A
L
E
I
V
T
Q
T
V
L
A
S
A
S
N
L
K
T
S
S
Q
S
P
H
D
F
I
D
A
I
C
S
P
G
G
T
T
I
A
G
L
M
E
L
E
R
L
G
L
T
A
T
V
S
S
A
I
D
K
T
I
D
K
A
----------------
71
PsiBlast_CBE
84.48
31%
-133
- C4 -
2AMF
3
?
C:
[5-256]
--
K
I
G
I
I
G
V
G
K
M
A
S
A
I
I
K
G
L
K
Q
T
-----
P
H
E
L
I
I
S
G
S
S
L
E
R
S
K
E
I
A
E
Q
L
A
L
P
Y
A
M
S
H
Q
D
L
I
D
Q
V
D
L
V
I
L
G
I
K
P
Q
-
L
F
E
T
V
--
L
K
P
L
H
-
F
K
Q
--
P
I
I
S
M
A
A
G
I
S
L
Q
R
L
A
T
F
V
G
Q
D
L
P
L
L
R
I
M
P
N
M
N
A
Q
I
L
Q
S
S
T
A
L
T
G
N
A
L
V
S
Q
E
L
Q
A
R
V
R
D
L
T
D
S
F
G
-
S
T
F
D
I
S
-
E
K
D
F
D
T
F
T
A
L
A
G
S
S
P
A
Y
I
Y
L
F
I
E
A
L
A
K
A
G
V
K
N
G
I
P
K
A
K
A
L
E
I
V
T
Q
T
V
L
A
S
A
S
N
L
K
T
S
S
Q
S
P
H
D
F
I
D
A
I
C
S
P
G
G
T
T
I
A
G
L
M
E
L
E
R
L
G
L
T
A
T
V
S
S
A
I
D
K
T
I
D
K
A
----------------
70
PsiBlast_CBE
83.93
31%
-137
- C4 -
2AMF
3
?
D:
[5-256]
--
K
I
G
I
I
G
V
G
K
M
A
S
A
I
I
K
G
L
K
Q
T
-----
P
H
E
L
I
I
S
G
S
S
L
E
R
S
K
E
I
A
E
Q
L
A
L
P
Y
A
M
S
H
Q
D
L
I
D
Q
V
D
L
V
I
L
G
I
K
P
Q
-
L
F
E
T
V
--
L
K
P
L
H
-
F
K
Q
--
P
I
I
S
M
A
A
G
I
S
L
Q
R
L
A
T
F
V
G
Q
D
L
P
L
L
R
I
M
P
N
M
N
A
Q
I
L
Q
S
S
T
A
L
T
G
N
A
L
V
S
Q
E
L
Q
A
R
V
R
D
L
T
D
S
F
G
-
S
T
F
D
I
S
-
E
K
D
F
D
T
F
T
A
L
A
G
S
S
P
A
Y
I
Y
L
F
I
E
A
L
A
K
A
G
V
K
N
G
I
P
K
A
K
A
L
E
I
V
T
Q
T
V
L
A
S
A
S
N
L
K
T
S
S
Q
S
P
H
D
F
I
D
A
I
C
S
P
G
G
T
T
I
A
G
L
M
E
L
E
R
L
G
L
T
A
T
V
S
S
A
I
D
K
T
I
D
K
A
----------------
11
PsiBlast_PDB
83.61
31%
-139
- C4 -
2AMF
3
?
A:
[5-256]
--
K
I
G
I
I
G
V
G
K
M
A
S
A
I
I
K
G
L
K
Q
T
-----
P
H
E
L
I
I
S
G
S
S
L
E
R
S
K
E
I
A
E
Q
L
A
L
P
Y
A
M
S
H
Q
D
L
I
D
Q
V
D
L
V
I
L
G
I
K
P
Q
-
L
F
E
T
V
--
L
K
P
L
H
-
F
K
Q
--
P
I
I
S
M
A
A
G
I
S
L
Q
R
L
A
T
F
V
G
Q
D
L
P
L
L
R
I
M
P
N
M
N
A
Q
I
L
Q
S
S
T
A
L
T
G
N
A
L
V
S
Q
E
L
Q
A
R
V
R
D
L
T
D
S
F
G
-
S
T
F
D
I
S
-
E
K
D
F
D
T
F
T
A
L
A
G
S
S
P
A
Y
I
Y
L
F
I
E
A
L
A
K
A
G
V
K
N
G
I
P
K
A
K
A
L
E
I
V
T
Q
T
V
L
A
S
A
S
N
L
K
T
S
S
Q
S
P
H
D
F
I
D
A
I
C
S
P
G
G
T
T
I
A
G
L
M
E
L
E
R
L
G
L
T
A
T
V
S
S
A
I
D
K
T
I
D
K
A
----------------
72
PsiBlast_CBE
83.53
31%
-134
- C4 -
2AMF
3
?
B:
[5-256]
--
K
I
G
I
I
G
V
G
K
M
A
S
A
I
I
K
G
L
K
Q
T
-----
P
H
E
L
I
I
S
G
S
S
L
E
R
S
K
E
I
A
E
Q
L
A
L
P
Y
A
M
S
H
Q
D
L
I
D
Q
V
D
L
V
I
L
G
I
K
P
Q
-
L
F
E
T
V
--
L
K
P
L
H
-
F
K
Q
--
P
I
I
S
M
A
A
G
I
S
L
Q
R
L
A
T
F
V
G
Q
D
L
P
L
L
R
I
M
P
N
M
N
A
Q
I
L
Q
S
S
T
A
L
T
G
N
A
L
V
S
Q
E
L
Q
A
R
V
R
D
L
T
D
S
F
G
-
S
T
F
D
I
S
-
E
K
D
F
D
T
F
T
A
L
A
G
S
S
P
A
Y
I
Y
L
F
I
E
A
L
A
K
A
G
V
K
N
G
I
P
K
A
K
A
L
E
I
V
T
Q
T
V
L
A
S
A
S
N
L
K
T
S
S
Q
S
P
H
D
F
I
D
A
I
C
S
P
G
G
T
T
I
A
G
L
M
E
L
E
R
L
G
L
T
A
T
V
S
S
A
I
D
K
T
I
D
K
A
----------------
13
PsiBlast_PDB
79.28
35%
-81
- C4 -
2AG8
1
?
A:
[27-262]
------------------------------
I
Y
I
A
N
R
G
A
E
K
R
E
-
R
L
E
K
E
L
G
V
E
T
S
A
T
L
P
E
L
H
S
D
-
D
V
L
I
L
A
V
K
P
Q
D
M
E
A
A
C
K
N
I
R
--
T
-
N
G
A
--
L
V
L
S
V
A
A
G
L
S
V
G
T
L
S
R
Y
L
G
G
T
R
R
I
V
R
V
M
P
N
T
P
G
K
I
G
L
G
V
S
G
M
Y
A
E
A
E
V
S
E
T
D
R
R
I
A
D
R
I
M
K
S
V
G
L
T
V
W
L
D
D
-
E
E
K
M
H
G
I
T
G
I
S
G
S
G
P
A
Y
V
F
Y
L
L
D
A
L
Q
N
A
A
I
R
Q
G
F
D
M
A
E
A
R
A
L
S
L
A
T
F
K
G
A
V
A
L
A
E
Q
T
G
E
D
F
E
K
L
Q
K
N
V
T
S
K
G
G
T
T
H
E
A
V
E
A
F
R
R
H
R
V
A
E
A
I
S
E
G
V
C
A
C
V
R
R
S
Q
E
M
E
R
Q
Y
---------