@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu24060: (2016-07-07 )
MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLHKGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLMKKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPGLEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILPTEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKMLVSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHEGIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAIGKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTIHPHPTLSEAIGEAALAADGKAIHF
Atome Classification :
(45 SA)
.........10........20........30....-.-------.-------..40........50.......-.60...---.-..---.---.-70.-.-.-.-....80........90........100..-.....110.......120--.......130...-------.-----...140.........150.......160--...---....170......-.-180.........190.......200.......210.......220.......-.230..-.....240.......250..-..-----...260--.--...---...270----------.......280-.......290...-.-.-.-.300.......310.......320.-.-.-....330.......340.....-..350........360........370.......380.......390.......400.----......410.......420.......430.......440.......--450.......460.......470..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
T
E
Y
D
V
V
I
L
GGGT
G
G
Y
V
A
A
I
R
A
A
QLGL
K
T
A
V
V
EK-E-------K-------LG
G
T
C
LHKGCI
P
S
K
A
L
L
R
S
A
E
-
V
Y
R
T
A
R
---
E
-
A
D
---
Q
---F-GVE-T-A-G-
V
S
L
N
F
E
K
V
Q
Q
R
K
Q
A
V
V
D
K
L
A
A
G
V
N
H
L
M
KK-GKI
D
V
Y
TGYGRIL
G
P
S
IF--SPLP
G
T
I
S
V
ERGN-------G-----EEN
D
--
M
L
I
P
K
Q
V
I
I
ATGSRPRMLPGLE--VDG---KSVLT
S
D
E
A
L
Q
M
E
-E-L--PQ
S
I
I
I
VGG
G
V
I
G
I
E
W
A
S
M
L
H
DFG
V
K
V
T
V
I
E
Y
A
D
RILPTE-
D
L
E
I
S
K
E
M
-
E
S
L
L
K
K-KG
I
Q
F
ITGAKVLPDTMTKTS-D
D
-----
I
S
I
Q
AE--K--DG
E
---
T
V
T
Y
S
A
----------
E
K
M
L
V
S
IGRQ-ANI
E
G
IGLEN
T
D
I
-V-T-E-N
G
M
I
SVNESCQTKES
H
I
Y
A
I
G
D
VIG-G-L-
Q
L
A
H
VASHE
G
I
I
A
V
E
H
FAGLNP-HPL-
D
P
T
L
V
P
K
C
IYS-SPEAASVGLTE
D
E
AKANGHNVKIGK
F
P
F
M
A
I
G
K
A
L
V
YGESD
G
----
F
V
K
I
V
ADRDTD
D
I
L
G
V
H
MIG
P
H
V
T
D
M
I
S
E
A
G
L
A
K
V
LDATPWEVGQT--IHPHP
T
L
S
E
A
I
G
E
A
A
LAADGKAIHF
107
HHSearch
92.64
41%
-78
- C3 -
1EBD
2
DLDH1_GEOSE
A:
[2-455]
--
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-
G
-------
N
-------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
-
R
Y
E
Q
A
K
---
H
-
S
E
---
E
---
M
-
G
I
K
-
A
-
E
-
N
-
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
-
N
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
---------
N
T
V
R
V
V
N
G
D
--------------
S
A
Q
--
T
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
K
--
F
-
S
---
N
R
I
L
D
S
T
G
A
L
N
L
G
-
E
-
V
--
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
-
E
K
Q
M
A
A
I
I
-
K
K
R
L
K
K
-
K
G
V
E
V
V
T
N
A
L
A
K
G
A
E
E
R
--
E
-
D
G
-----
V
T
V
T
Y
E
--
A
--
N
G
E
---
T
K
T
I
D
A
----------
D
Y
V
L
V
T
V
G
R
R
-
P
N
T
D
E
L
G
L
E
Q
I
G
I
-
K
-
M
-
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
-
G
-
P
-
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
H
P
--
S
A
V
-
D
Y
V
A
I
P
A
V
V
F
S
-
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
----
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
--
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
E
V
A
L
------
23
PsiBlast_CBE
89.62
40%
-77
- C3 -
1EBD
2
DLDH1_GEOSE
B:
[1-451]
-
A
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-
G
-------
N
-------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
-
R
Y
E
Q
A
K
---
H
-
S
E
---
E
---
M
-
G
I
K
-
A
-
E
-
N
-
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
-
N
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
N
-----------
T
V
R
V
V
N
-------
G
-----
D
S
A
Q
--
T
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
K
--
F
S
N
---
R
-
I
L
D
S
T
G
A
L
N
L
G
-
E
-
V
--
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
-
E
K
Q
M
A
A
I
I
-
K
K
R
L
K
K
-
K
G
V
E
V
V
T
N
A
--
L
A
K
G
A
E
E
R
E
-
D
G
-----
V
T
V
T
Y
E
--
A
--
N
G
E
---
T
K
T
I
D
A
----------
D
Y
V
L
V
T
V
G
R
R
-
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
-
T
-
N
-
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
-
G
-
P
-
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
-
H
P
-
S
A
V
-
D
Y
V
A
I
P
A
V
V
F
S
-
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
----
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
--
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
----------
3
PsiBlast_PDB
88.84
40%
-77
- C3 -
1EBD
2
DLDH1_GEOSE
A:
[1-451]
-
A
I
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-
G
-------
N
-------
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
-
R
Y
E
Q
A
K
---
H
-
S
E
---
E
---
M
-
G
I
K
-
A
-
E
-
N
-
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
-
N
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
N
-----------
T
V
R
V
V
N
-------
G
-----
D
S
A
Q
--
T
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
K
--
F
S
N
---
R
-
I
L
D
S
T
G
A
L
N
L
G
-
E
-
V
--
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
-
E
K
Q
M
A
A
I
I
-
K
K
R
L
K
K
-
K
G
V
E
V
V
T
N
A
--
L
A
K
G
A
E
E
R
E
-
D
G
-----
V
T
V
T
Y
E
--
A
--
N
G
E
---
T
K
T
I
D
A
----------
D
Y
V
L
V
T
V
G
R
R
-
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
-
T
-
N
-
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
P
-
G
-
P
-
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
A
G
-
H
P
-
S
A
V
-
D
Y
V
A
I
P
A
V
V
F
S
-
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
----
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
--
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
----------
104
HHSearch
85.04
41%
-29
- C3 -
2EQ6
2
?
A:
[4-458]
-
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
-
T
L
H
H
L
K
---
V
-
A
E
---
G
---
F
-
G
L
K
-
A
---
K
-
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
---------
K
E
V
E
V
------------------
G
G
E
--
R
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
-
G
---
E
D
V
W
D
S
T
R
A
L
K
V
E
E
G
-
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
--
K
-
D
G
-----
L
H
V
R
L
E
PA
E
--
G
G
E
---
G
E
E
V
V
V
----------
D
K
V
L
V
A
V
G
R
K
-
P
R
T
E
G
L
G
L
E
K
A
G
V
-
K
-
V
-
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
A
F
-
D
Y
-
Q
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
---
74
PsiBlast_CBE
84.86
41%
-31
- C3 -
2EQ9
2
?
D:
[7-461]
----
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
-
T
L
H
H
L
K
---
V
-
A
E
---
G
---
F
-
G
L
K
---
A
-
K
-
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
-----------
E
V
E
V
G
--------
G
-----
E
R
Y
G
--
A
---
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
-
G
---
E
D
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
-
L
H
-----
V
R
L
E
P
A
--
E
--
G
G
E
---
G
E
E
V
V
V
----------
D
K
V
L
V
A
V
G
R
K
-
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
-
D
-
E
-
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
A
F
-
D
-
Y
Q
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
76
PsiBlast_CBE
84.76
41%
-33
- C3 -
2EQ9
2
?
A:
[7-461]
----
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
-
T
L
H
H
L
K
---
V
-
A
E
---
G
---
F
-
G
L
K
---
A
-
K
-
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
-----------
E
V
E
V
G
--------
G
-----
E
R
Y
G
--
A
---
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
-
G
---
E
D
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
-
L
H
-----
V
R
L
E
P
A
--
E
--
G
G
E
---
G
E
E
V
V
V
----------
D
K
V
L
V
A
V
G
R
K
-
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
-
D
-
E
-
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
A
F
-
D
-
Y
Q
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
71
PsiBlast_CBE
84.65
41%
-30
- C3 -
2EQ9
2
?
H:
[7-461]
----
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
-
T
L
H
H
L
K
---
V
-
A
E
---
G
---
F
-
G
L
K
---
A
-
K
-
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
-----------
E
V
E
V
G
--------
G
-----
E
R
Y
G
--
A
---
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
-
G
---
E
D
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
-
L
H
-----
V
R
L
E
P
A
--
E
--
G
G
E
---
G
E
E
V
V
V
----------
D
K
V
L
V
A
V
G
R
K
-
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
-
D
-
E
-
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
A
F
-
D
-
Y
Q
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
75
PsiBlast_CBE
84.55
41%
-31
- C3 -
2EQ9
2
?
B:
[7-461]
----
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
-
T
L
H
H
L
K
---
V
-
A
E
---
G
---
F
-
G
L
K
---
A
-
K
-
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
-----------
E
V
E
V
G
--------
G
-----
E
R
Y
G
--
A
---
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
-
G
---
E
D
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
-
L
H
-----
V
R
L
E
P
A
--
E
--
G
G
E
---
G
E
E
V
V
V
----------
D
K
V
L
V
A
V
G
R
K
-
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
-
D
-
E
-
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
A
F
-
D
-
Y
Q
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
78
PsiBlast_CBE
84.40
41%
-33
- C3 -
2EQ8
2
?
D:
[7-461]
----
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
-
T
L
H
H
L
K
---
V
-
A
E
---
G
---
F
-
G
L
K
---
A
-
K
-
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
-----------
E
V
E
V
G
--------
G
-----
E
R
Y
G
--
A
---
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
-
G
---
E
D
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
-
L
H
-----
V
R
L
E
P
A
--
E
--
G
G
E
---
G
E
E
V
V
V
----------
D
K
V
L
V
A
V
G
R
K
-
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
-
D
-
E
-
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
A
F
-
D
-
Y
Q
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
70
PsiBlast_CBE
84.37
41%
-29
- C3 -
2EQ9
2
?
J:
[7-461]
----
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
-
T
L
H
H
L
K
---
V
-
A
E
---
G
---
F
-
G
L
K
---
A
-
K
-
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
-----------
E
V
E
V
G
--------
G
-----
E
R
Y
G
--
A
---
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
-
G
---
E
D
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
-
L
H
-----
V
R
L
E
P
A
--
E
--
G
G
E
---
G
E
E
V
V
V
----------
D
K
V
L
V
A
V
G
R
K
-
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
-
D
-
E
-
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
A
F
-
D
-
Y
Q
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
69
PsiBlast_CBE
84.12
41%
-32
- C3 -
2EQ9
2
?
K:
[7-461]
----
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
-
T
L
H
H
L
K
---
V
-
A
E
---
G
---
F
-
G
L
K
---
A
-
K
-
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
-----------
E
V
E
V
G
--------
G
-----
E
R
Y
G
--
A
---
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
-
G
---
E
D
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
-
L
H
-----
V
R
L
E
P
A
--
E
--
G
G
E
---
G
E
E
V
V
V
----------
D
K
V
L
V
A
V
G
R
K
-
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
-
D
-
E
-
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
A
F
-
D
-
Y
Q
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
2
PsiBlast_PDB
84.06
44%
-17
- C3 -
2YQU
4
?
A:
[2-455]
----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
-
E
-------
K
A------
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
-
R
I
Y
E
A
K
---
K
-
G
----
L
---
L
-
G
A
K
-
V
-
K
-
G
-
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
-
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
---------
K
V
L
V
E
E
-
T
-------
G
-----
E
E
-----
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
--
V
D
Y
---
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
--
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
A
A
-
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
G
-
A
R
-----
V
E
L
E
G
-------
G
E
---
V
L
--
E
A
----------
D
R
V
L
V
A
V
G
R
R
-
P
Y
T
E
G
L
S
L
E
N
A
G
L
-
S
-
T
D
E
-
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
-
G
-
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
-
H
-
V
-
D
Y
Q
A
I
P
S
V
V
Y
T
-
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
--
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
L
20
PsiBlast_PDB
83.89
41%
-30
- C3 -
2EQ8
2
?
A:
[7-461]
----
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
-
T
L
H
H
L
K
---
V
-
A
E
---
G
---
F
-
G
L
K
---
A
-
K
-
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
-----------
E
V
E
V
G
--------
G
-----
E
R
Y
G
--
A
---
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
-
G
---
E
D
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
-
L
H
-----
V
R
L
E
P
A
--
E
--
G
G
E
---
G
E
E
V
V
V
----------
D
K
V
L
V
A
V
G
R
K
-
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
-
D
-
E
-
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
A
F
-
D
-
Y
Q
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
19
PsiBlast_PDB
83.88
41%
-31
- C3 -
2EQ6
2
?
A:
[7-461]
----
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
-
T
L
H
H
L
K
---
V
-
A
E
---
G
---
F
-
G
L
K
---
A
-
K
-
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
-----------
E
V
E
V
G
--------
G
-----
E
R
Y
G
--
A
---
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
-
G
---
E
D
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
-
L
H
-----
V
R
L
E
P
A
--
E
--
G
G
E
---
G
E
E
V
V
V
----------
D
K
V
L
V
A
V
G
R
K
-
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
-
D
-
E
-
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
A
F
-
D
-
Y
Q
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
72
PsiBlast_CBE
83.81
41%
-30
- C3 -
2EQ9
2
?
G:
[7-461]
----
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
-
T
L
H
H
L
K
---
V
-
A
E
---
G
---
F
-
G
L
K
---
A
-
K
-
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
-----------
E
V
E
V
G
--------
G
-----
E
R
Y
G
--
A
---
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
-
G
---
E
D
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
-
L
H
-----
V
R
L
E
P
A
--
E
--
G
G
E
---
G
E
E
V
V
V
----------
D
K
V
L
V
A
V
G
R
K
-
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
-
D
-
E
-
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
A
F
-
D
-
Y
Q
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
12
PsiBlast_PDB
83.48
41%
-19
- C3 -
4M52
4
DLDH_MYCTU
A:
[4-466]
--
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-
K
-------
Y
-------
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
H
I
F
T
K
---
D
-
A
K
---
A
---
F
-
G
I
--
S
-
G
-
E
-
V
T
F
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
G
V
H
F
L
M
K
K
-
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
---------
T
L
L
V
D
L
N
D
-------
G
-----
G
T
E
S
--
V
T
F
-
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
G
T
S
--
L
S
A
----
N
V
V
T
Y
E
E
Q
I
L
S
R
-
E
-
L
--
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
-
D
A
D
V
S
K
E
I
-
E
K
Q
F
K
K
-
L
G
V
T
I
L
T
A
T
K
V
--
E
S
I
A
D
G
G
-
S
Q
-----
V
T
V
T
V
T
--
K
--
D
G
V
---
A
Q
E
L
K
A
----------
E
K
V
L
Q
A
I
G
F
A
-
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
-
T
-
D
-
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
-
L
-
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
-
L
T
L
G
D
H
R
M
L
P
R
A
T
F
C
-
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
----
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
--
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
H
G
L
V
G
H
M
I
N
F
80
PsiBlast_CBE
83.36
41%
-31
- C3 -
2EQ6
2
?
B:
[7-461]
----
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
-
T
L
H
H
L
K
---
V
-
A
E
---
G
---
F
-
G
L
K
---
A
-
K
-
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
-----------
E
V
E
V
G
--------
G
-----
E
R
Y
G
--
A
---
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
-
G
---
E
D
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
-
L
H
-----
V
R
L
E
P
A
--
E
--
G
G
E
---
G
E
E
V
V
V
----------
D
K
V
L
V
A
V
G
R
K
-
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
-
D
-
E
-
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
A
F
-
D
-
Y
Q
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
79
PsiBlast_CBE
83.23
41%
-31
- C3 -
2EQ8
2
?
B:
[7-461]
----
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
-
T
L
H
H
L
K
---
V
-
A
E
---
G
---
F
-
G
L
K
---
A
-
K
-
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
-----------
E
V
E
V
G
--------
G
-----
E
R
Y
G
--
A
---
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
-
G
---
E
D
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
-
L
H
-----
V
R
L
E
P
A
--
E
--
G
G
E
---
G
E
E
V
V
V
----------
D
K
V
L
V
A
V
G
R
K
-
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
-
D
-
E
-
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
A
F
-
D
-
Y
Q
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
21
PsiBlast_CBE
83.20
44%
-16
- C3 -
2YQU
6
?
B:
[2-455]
----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
-
E
-------
K
A------
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
-
R
I
Y
E
A
K
---
K
-
G
----
L
---
L
-
G
A
K
-
V
-
K
-
G
-
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
-
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
---------
K
V
L
V
E
E
-
T
-------
G
-----
E
E
-----
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
--
V
D
Y
---
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
--
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
A
A
-
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
G
-
A
R
-----
V
E
L
E
G
-------
G
E
---
V
L
--
E
A
----------
D
R
V
L
V
A
V
G
R
R
-
P
Y
T
E
G
L
S
L
E
N
A
G
L
-
S
-
T
D
E
-
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
-
G
-
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
-
H
-
V
-
D
Y
Q
A
I
P
S
V
V
Y
T
-
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
--
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
L
77
PsiBlast_CBE
83.08
41%
-30
- C3 -
2EQ8
2
?
E:
[7-461]
----
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
-------
E
-------
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
-
T
L
H
H
L
K
---
V
-
A
E
---
G
---
F
-
G
L
K
---
A
-
K
-
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
-
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
-----------
E
V
E
V
G
--------
G
-----
E
R
Y
G
--
A
---
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
-
G
---
E
D
V
W
D
S
T
R
A
L
K
V
E
-
E
G
L
--
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
-
D
P
E
T
A
A
L
L
-
R
R
A
L
E
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
E
K
K
K
D
G
-
L
H
-----
V
R
L
E
P
A
--
E
--
G
G
E
---
G
E
E
V
V
V
----------
D
K
V
L
V
A
V
G
R
K
-
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
-
D
-
E
-
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
R
-
P
-
P
-
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
A
G
K
D
--
S
A
F
-
D
-
Y
Q
V
P
S
V
V
Y
T
-
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
----
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
--
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
22
PsiBlast_CBE
81.86
44%
-17
- C3 -
2EQ7
3
?
B:
[2-452]
----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
-
E
-------
K
A------
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
-
R
I
Y
E
A
K
---
K
-
G
----
L
---
L
-
G
A
K
-
V
-
K
-
G
-
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
-
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
---------
K
V
L
V
E
E
-
T
-------
G
-----
E
E
-----
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
--
V
D
Y
---
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
--
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
-
D
L
E
V
S
R
A
A
-
E
R
V
F
K
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
K
G
-
A
R
-----
V
E
L
E
G
-------
G
E
---
V
L
--
E
A
----------
D
R
V
L
V
A
V
G
R
R
-
P
Y
T
E
G
L
S
L
E
N
A
G
L
-
S
-
T
D
E
-
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
R
-
G
-
P
-
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
V
R
G
F
G
-
H
-
V
-
D
Y
Q
A
I
P
S
V
V
Y
T
-
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
----
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
--
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
---
13
PsiBlast_PDB
81.43
41%
-17
- C3 -
2A8X
3
DLDH_MYCTU
A:
[2-464]
--
T
H
Y
D
V
V
V
L
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
S
T
A
I
V
E
P
-
K
-------
Y
-------
W
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
R
N
A
E
L
V
H
I
F
T
K
---
D
-
A
K
---
A
---
F
-
G
I
--
S
-
G
-
E
-
V
T
F
D
Y
G
I
A
Y
D
R
S
R
K
V
A
E
G
R
V
A
G
V
H
F
L
M
K
K
-
N
K
I
T
E
I
H
G
Y
G
T
F
A
D
A
N
---------
T
L
L
V
D
L
N
D
-------
G
-----
G
T
E
S
--
V
T
F
-
D
N
A
I
I
A
T
G
S
S
T
R
L
V
P
G
T
S
--
L
S
A
----
N
V
V
T
Y
E
E
Q
I
L
S
R
-
E
-
L
--
P
K
S
I
I
I
A
G
A
G
A
I
G
M
E
F
G
Y
V
L
K
N
Y
G
V
D
V
T
I
V
E
F
L
P
R
A
L
P
N
E
-
D
A
D
V
S
K
E
I
-
E
K
Q
F
K
K
-
L
G
V
T
I
L
T
A
T
K
V
--
E
S
I
A
D
G
G
-
S
Q
-----
V
T
V
T
V
T
--
K
--
D
G
V
---
A
Q
E
L
K
A
----------
E
K
V
L
Q
A
I
G
F
A
-
P
N
V
E
G
Y
G
L
D
K
A
G
V
A
L
-
T
-
D
-
R
K
A
I
G
V
D
D
Y
M
R
T
N
V
G
H
I
Y
A
I
G
D
V
N
G
-
L
-
L
-
Q
L
A
H
V
A
E
A
Q
G
V
V
A
A
E
T
I
A
G
A
E
T
-
L
T
L
G
D
H
R
M
L
P
R
A
T
F
C
-
Q
P
N
V
A
S
F
G
L
T
E
Q
Q
A
R
N
E
G
Y
D
V
V
V
A
K
F
P
F
T
A
N
A
K
A
H
G
V
G
D
P
S
G
----
F
V
K
L
V
A
D
A
K
H
G
E
L
L
G
G
H
L
V
G
H
D
V
A
E
L
L
P
E
L
T
L
A
Q
R
W
D
L
T
A
S
E
L
A
R
N
--
V
H
T
H
P
T
M
S
E
A
L
Q
E
C
F
H
G
L
V
G
H
M
I
N
F