@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu24170: (2016-07-08 )
MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVSGDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMIRAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVHGNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDEAIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATILGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFDLEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQVH
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MR
K
T
V
I
V
SAART
P
F
G
K
F
G
G
V
L
K
E
V
K
A
A
E
L
G
G
I
V
M
K
E
A
L
Q
QAGVSGDDVEG
N
V
M
G
M
V
V
QAGSGQIP
S
R
Q
A
A
R
LAGMPWSV
P
S
E
T
L
N
K
V
C
A
SG
L
R
A
V
T
L
C
D
Q
M
I
RAQDA
D
I
L
V
AGG
M
E
S
MSNIPYAVPAGRWGARMGDGE
L
R
D
L
M
V
YDGL
T
C
A
F
D
E
V
H
M
A
VHGNT
A
A
K
E
Y
A
I
SRR
E
Q
D
E
W
A
L
R
S
H
A
R
AAKAADEGKFQDEIVPVNWIGRKGKPNVV
D
K
D
E
A
IRRDT
S
L
D
Q
L
A
K
LA
P
I
YASDGSITAGNAPGVNDG
A
G
A
F
V
L
MS
E
E
K
A
A
E
LGKR
P
L
A
T
I
LGFSTTGM
P
A
H
E
LAAA
P
G
F
A
I
N
K
L
L
K
KNG
L
T
V
Q
D
I
D
L
F
E
V
N
E
A
F
A
S
V
V
L
T
C
E
K
I
VG
F
D
L
E
K
V
NVNG
G
A
I
A
LGHPIGAS
G
A
R
I
L
M
T
L
V
Y
E
L
K
RRGGGL
G
V
A
A
I
CSGAAQG
D
A
V
L
V
QVH
119
HHSearch
88.95
49%
-85
- C5 -
4O9A
-
THIL_CUPNH
A:
[4-392]
---
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
K
A
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
-
8
PsiBlast_PDB
88.91
48%
-83
- C5 -
4O9C
-
THIL_CUPNH
A:
[1-391]
M
T
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
K
A
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
--
32
PsiBlast_CBE
88.89
48%
-83
- C5 -
4O9C
1
THIL_CUPNH
H:
[1-391]
M
T
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
K
A
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
--
31
PsiBlast_CBE
88.86
49%
-85
- C5 -
4O99
1
THIL_CUPNH
B:
[4-390]
----
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
C
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
K
A
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
--
30
PsiBlast_CBE
88.76
49%
-86
- C5 -
4O99
1
THIL_CUPNH
C:
[4-390]
----
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
C
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
K
A
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
--
7
PsiBlast_PDB
88.68
49%
-86
- C5 -
4O99
1
THIL_CUPNH
A:
[4-390]
----
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
C
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
K
A
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
--
33
PsiBlast_CBE
88.42
48%
-82
- C5 -
4O9C
1
THIL_CUPNH
C:
[1-391]
M
T
D
V
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
K
A
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
--
9
PsiBlast_PDB
88.04
49%
-85
- C5 -
4O9A
-
THIL_CUPNH
A:
[5-391]
----
V
I
V
S
A
A
R
T
A
V
G
K
F
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
G
V
K
P
E
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
S
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
V
L
P
G
S
R
D
G
F
R
M
G
D
A
K
L
V
D
T
M
I
V
D
G
L
W
D
V
Y
N
Q
Y
H
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
Q
R
K
G
D
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
D
S
M
S
G
L
K
P
A
F
D
K
A
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
--
2
PsiBlast_PDB
87.77
49%
-79
- C5 -
4WYR
5
THLA_CLOAB
A:
[1-390]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
Q
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
N
A
R
W
G
Y
R
M
G
N
A
K
F
V
D
E
M
I
T
D
G
L
W
D
A
F
Y
D
Y
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
-
T
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
K
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
--
109
HHSearch
87.48
46%
-84
* C5 *
2VU1
5
THIL_ZOORA
A:
[2-391]
T
P
S
I
V
I
A
S
A
A
R
T
A
V
G
S
F
N
G
A
F
A
N
T
P
A
H
E
L
G
A
T
V
I
S
A
V
L
E
R
A
G
V
A
A
G
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
E
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
C
A
H
L
-
R
G
G
V
K
M
G
D
F
K
M
I
D
T
M
I
K
D
G
L
T
D
A
F
Y
G
Y
H
M
G
T
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
F
I
V
K
G
R
K
-
G
D
I
T
V
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
A
F
D
K
E
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
D
P
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
K
R
R
G
A
R
K
G
L
A
T
L
C
I
G
G
G
M
G
V
A
M
C
I
E
S
-
24
PsiBlast_CBE
87.27
49%
-78
- C5 -
4WYR
3
THLA_CLOAB
B:
[1-390]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
Q
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
N
A
R
W
G
Y
R
M
G
N
A
K
F
V
D
E
M
I
T
D
G
L
W
D
A
F
Y
D
Y
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
-
T
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
K
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
--
3
PsiBlast_PDB
86.69
48%
-75
- C5 -
4N45
-
?
A:
[1-390]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
N
A
R
W
G
Y
R
M
G
N
A
K
F
V
D
E
M
I
T
D
G
L
W
D
A
F
N
D
Y
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
-
T
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
--
1
PsiBlast_PDB
86.55
49%
-77
- C5 -
4N44
2
?
A:
[1-390]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
N
A
R
W
G
Y
R
M
G
N
A
K
F
V
D
E
M
I
T
D
G
L
W
D
A
F
N
D
Y
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
-
T
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
--
11
PsiBlast_PDB
86.48
46%
-85
- C5 -
1DLV
5
THIL_ZOORA
A:
[3-387]
----
V
I
A
S
A
A
R
T
A
V
G
S
F
N
G
A
F
A
N
T
P
A
H
E
L
G
A
T
V
I
S
A
V
L
E
R
A
G
V
A
A
G
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
E
G
Q
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
C
A
H
L
-
R
G
G
V
K
M
G
D
F
K
M
I
D
T
M
I
K
D
G
L
T
D
A
F
Y
G
Y
H
M
G
T
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
F
I
V
K
G
R
K
G
D
I
T
V
-
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
A
F
D
K
E
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
D
P
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
K
R
R
G
A
R
K
G
L
A
T
L
C
I
G
G
G
M
G
V
A
M
C
I
E
--
25
PsiBlast_CBE
86.36
48%
-79
- C5 -
4XL4
4
?
B:
[1-390]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
N
A
R
W
G
Y
R
M
G
N
A
K
F
V
D
E
M
I
T
D
G
L
W
D
A
F
N
D
Y
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
-
T
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
--
4
PsiBlast_PDB
86.22
48%
-77
- C5 -
4XL3
4
?
A:
[1-390]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
N
A
R
W
G
Y
R
M
G
N
A
K
F
V
D
E
M
I
T
D
G
L
W
D
A
F
N
D
Y
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
-
T
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
--
103
HHSearch
86.09
43%
-83
- C5 -
3SS6
6
?
A:
[4-393]
M
H
N
V
V
I
T
A
A
V
R
S
P
I
G
T
F
G
G
A
L
K
N
V
T
P
V
E
L
A
V
P
V
L
Q
E
A
V
K
R
G
G
V
E
P
H
E
V
D
E
V
I
L
G
H
C
I
Q
R
T
D
E
A
N
T
A
R
T
A
A
L
A
A
G
F
P
D
T
V
T
G
Y
T
I
Q
R
Q
C
S
S
G
M
Q
A
I
M
S
A
A
M
Q
I
Q
L
G
V
S
E
V
V
V
A
G
G
V
E
A
M
S
S
S
P
Y
A
L
K
Q
H
R
W
G
Q
R
L
Q
H
G
E
I
R
D
T
V
W
E
-
V
L
E
D
P
I
H
H
I
M
M
G
E
T
A
E
N
L
V
E
Q
Y
E
I
T
R
E
E
Q
D
E
V
A
L
R
S
H
T
L
A
L
K
A
I
E
S
G
Y
F
D
D
Q
I
V
P
I
T
I
K
-
E
R
R
K
E
V
V
F
S
K
D
E
H
P
R
A
D
I
T
A
E
K
L
A
G
L
K
P
A
F
R
K
D
G
S
V
T
A
G
N
A
S
G
L
N
D
G
S
A
V
L
V
L
M
S
E
E
K
A
K
E
K
G
L
Q
P
L
A
R
I
V
G
Y
S
V
A
G
V
D
P
K
I
M
G
I
G
P
A
P
A
I
R
K
G
L
E
K
V
D
W
S
L
E
D
A
D
L
L
E
I
N
E
A
F
A
A
Q
Y
L
A
V
E
K
E
L
D
L
D
R
E
K
V
N
V
N
G
S
G
V
G
L
G
H
P
I
G
C
T
G
A
R
I
T
V
S
L
I
H
E
L
K
R
R
G
L
E
K
G
I
A
S
L
C
V
G
G
G
I
G
V
A
L
F
I
E
A
-
15
PsiBlast_PDB
85.99
46%
-82
- C5 -
1M1T
4
THIL_ZOORA
A:
[6-390]
----
V
I
A
S
A
A
R
T
A
V
G
S
F
N
G
A
F
A
N
T
P
A
H
E
L
G
A
T
V
I
S
A
V
L
E
R
A
G
V
A
A
G
E
V
N
E
V
I
L
G
Q
V
L
P
A
G
E
G
A
N
P
A
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
C
A
H
L
-
R
G
G
V
K
M
G
D
F
K
M
I
D
T
M
I
K
D
G
L
T
D
A
F
Y
G
Y
H
M
G
T
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
P
F
I
V
K
G
R
K
G
D
I
T
V
-
D
A
D
E
Y
I
R
H
G
A
T
L
D
S
M
A
K
L
R
P
A
F
D
K
E
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
D
P
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
K
R
R
G
A
R
K
G
L
A
T
L
C
I
G
G
G
M
G
V
A
M
C
I
E
--
22
PsiBlast_CBE
85.98
49%
-79
- C5 -
4XL2
7
THLA_CLOAB
A:
[1-390]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
N
A
R
W
G
Y
R
M
G
N
A
K
F
V
D
E
M
I
T
D
G
L
W
D
A
F
N
D
Y
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
-
T
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
---------
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
--
5
PsiBlast_PDB
85.94
48%
-78
- C5 -
4XL4
7
?
A:
[1-390]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
N
A
R
W
G
Y
R
M
G
N
A
K
F
V
D
E
M
I
T
D
G
L
W
D
A
F
N
D
Y
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
-
T
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
--
26
PsiBlast_CBE
85.75
48%
-75
- C5 -
4XL3
3
?
B:
[1-390]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
N
A
R
W
G
Y
R
M
G
N
A
K
F
V
D
E
M
I
T
D
G
L
W
D
A
F
N
D
Y
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
-
T
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
--
21
PsiBlast_CBE
85.70
49%
-80
- C5 -
4XL2
7
THLA_CLOAB
B:
[1-390]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
G
I
K
P
E
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
N
A
R
W
G
Y
R
M
G
N
A
K
F
V
D
E
M
I
T
D
G
L
W
D
A
F
N
D
Y
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
K
G
R
K
G
E
-
T
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
---------
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
M
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
--