@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu24180: (2016-07-08 )
MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGRIVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKKDFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERAVLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMKRLIEAGADGMFTDFPEKASALLKNE
Atome Classification :
(21 SA)
.........10........20.....-...30........40........50.......----------.60........70........80.-----------....--------...90........100.---.......110....--.------..120..-.----....130.-------..-....-140.......150.....------------------------..160...--.-..---.170...----------.------.....180....---.-----..190.......--200........210.-..-----....220.......230.......240.-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
K
I
F
AHRGASGQFPE
N
T
M
L
A
F
E
KGI-EAGAD
G
I
E
L
D
V
Q
LTKDG
R
I
V
V
I
HDERLNRTTS----------L
K
G
F
V
KDTAYDEVKTANAAAGHDQ-----------AYSD--------IK
V
P
L
L
E
D
V
L
S
W
A
VK-K---
D
F
L
I
N
I
E
LKN
S
V
I
R--Y------EG
M
E
E
K
V
-
L
----
E
A
V
K
RFNV-------E
D
-
R
V
I
L
-
S
TFN
H
D
S
L
A
L
C
A
R
L
A
P
H
I
------------------------
E
R
A
V
L
T
S
D
--
V
-
L
Y
---
Q
A
--
D
R
Y
----------
I
------
A
SIPASGYHPKI---N-----SPGV
T
D
E
V
L
K
K
M
--R-NG
L
I
K
VR
P
Y
TVN
R
-
P
E
-----
D
M
K
R
L
I
E
AGADGMFTDF
P
E
K
A
S
A
L
LKNE-----
21
PsiBlast_CBE
92.80
42%
-96
- C5 -
2PZ0
2
?
B:
[12-249]
-
T
L
V
I
A
H
R
G
D
S
K
N
V
P
E
N
T
I
A
A
F
K
R
A
M
-
E
L
G
A
D
G
I
E
L
D
V
Q
L
T
K
D
G
H
L
V
V
I
H
D
E
T
V
D
R
T
T
N
----------
G
E
G
F
V
K
D
F
T
L
E
E
I
K
K
L
D
A
G
I
K
F
G
E
-----------
K
F
A
G
--------
E
R
I
P
T
L
Y
E
V
F
E
L
I
G
D
-
K
---
D
F
L
V
N
I
E
I
K
S
G
I
V
L
--
Y
------
P
G
I
E
E
K
L
-
I
----
K
A
I
K
E
Y
N
F
-------
E
E
-
R
V
I
I
-
S
S
F
N
H
Y
S
L
R
D
V
K
K
M
A
P
H
L
------------------------
K
I
G
L
L
Y
Q
C
--
G
-
L
V
---
E
P
--
W
H
M
----------
A
------
L
R
M
E
A
Y
S
L
H
P
F
Y
---
F
-----
N
--
I
I
P
E
L
V
E
G
C
--
K
-
K
N
G
V
K
L
F
P
W
T
V
D
R
-
K
E
-----
D
M
E
R
M
I
K
A
G
V
D
G
I
I
T
D
D
P
E
T
L
I
N
L
V
R
-------
1
PsiBlast_PDB
92.68
42%
-93
- C5 -
2PZ0
2
?
A:
[12-249]
-
T
L
V
I
A
H
R
G
D
S
K
N
V
P
E
N
T
I
A
A
F
K
R
A
M
-
E
L
G
A
D
G
I
E
L
D
V
Q
L
T
K
D
G
H
L
V
V
I
H
D
E
T
V
D
R
T
T
N
----------
G
E
G
F
V
K
D
F
T
L
E
E
I
K
K
L
D
A
G
I
K
F
G
E
-----------
K
F
A
G
--------
E
R
I
P
T
L
Y
E
V
F
E
L
I
G
D
-
K
---
D
F
L
V
N
I
E
I
K
S
G
I
V
L
--
Y
------
P
G
I
E
E
K
L
-
I
----
K
A
I
K
E
Y
N
F
-------
E
E
-
R
V
I
I
-
S
S
F
N
H
Y
S
L
R
D
V
K
K
M
A
P
H
L
------------------------
K
I
G
L
L
Y
Q
C
--
G
-
L
V
---
E
P
--
W
H
M
----------
A
------
L
R
M
E
A
Y
S
L
H
P
F
Y
---
F
-----
N
--
I
I
P
E
L
V
E
G
C
--
K
-
K
N
G
V
K
L
F
P
W
T
V
D
R
-
K
E
-----
D
M
E
R
M
I
K
A
G
V
D
G
I
I
T
D
D
P
E
T
L
I
N
L
V
R
-------
52
HHSearch
87.22
43%
-28
- C5 -
2PZ0
2
?
A:
[11-249]
K
T
L
V
I
A
H
R
G
D
S
K
N
V
P
E
N
T
I
A
A
F
K
R
A
M
-
E
L
G
A
D
G
I
E
L
D
V
Q
L
T
K
D
G
H
L
V
V
I
H
D
E
T
V
D
R
T
T
N
----------
G
E
G
F
V
K
D
F
T
L
E
E
I
K
K
L
D
A
G
I
K
F
G
E
-----------
K
F
A
G
--------
E
R
I
P
T
L
Y
E
V
F
E
L
I
G
D
-
K
---
D
F
L
V
N
I
E
I
K
S
G
I
V
L
--
Y
------
P
G
I
E
E
-
K
-
L
I
---
K
A
I
K
E
Y
N
F
-------
E
E
-
R
V
I
I
-
S
S
F
N
H
Y
S
L
R
D
V
K
K
M
A
P
H
L
------------------------
K
I
G
L
L
Y
Q
C
G-
L
-
V
E
---
P
W
--
H
M
A
-----------------
L
R
M
E
A
Y
S
L
H
P
F
Y
----------
F
N
I
I
P
E
L
V
E
G
C
--
K
K
N
G
-
V
K
L
F
P
W
T
V
D
R
-
K
E
-----
D
M
E
R
M
I
K
A
G
V
D
G
I
I
T
D
D
P
E
T
L
I
N
L
V
R
-------
50
HHSearch
75.18
28%
-31
* C5 *
3QVQ
15
?
A:
[9-249]
L
P
Q
V
I
A
H
R
G
S
S
G
Q
A
P
E
N
T
L
A
S
L
H
L
A
G
-
Q
Q
G
I
K
W
V
E
I
D
V
M
L
S
G
D
G
I
P
V
I
F
H
D
D
Y
L
S
R
T
T
D
----------
G
D
G
L
I
Y
K
T
P
L
A
E
L
K
Q
L
D
A
G
S
W
K
G
Q
-----------
E
Y
Q
Q
--------
E
T
I
P
T
L
L
E
A
I
E
V
I
S
Q
-
Y
---
G
M
G
L
N
L
E
L
K
P
C
E
G
L
--
E
------
E
E
T
I
A
-
A
-
S
V
---
E
V
L
K
Q
H
W
P
-------
Q
D
L
P
L
L
F
-
S
S
F
N
Y
F
A
L
V
S
A
K
A
L
W
P
E
I
------------------------
A
R
G
Y
N
V
S
A
I-
P
-
S
A
---
W
Q
--
E
R
L
-----------------
E
H
L
D
C
A
G
L
H
I
H
Q
----------
S
F
F
D
V
Q
Q
V
S
D
I
--
K
A
A
G
-
Y
K
V
L
A
F
T
I
N
D
-
E
S
-----
L
A
L
K
L
Y
N
Q
G
L
D
A
V
F
S
D
Y
P
Q
K
I
Q
S
A
I
D
S
------
6
PsiBlast_PDB
72.84
28%
-26
- C5 -
3QVQ
15
?
A:
[9-242]
L
P
Q
V
I
A
H
R
G
S
S
G
Q
A
P
E
N
T
L
A
S
L
H
L
A
G
-
Q
Q
G
I
K
W
V
E
I
D
V
M
L
S
G
D
G
I
P
V
I
F
H
D
D
Y
L
S
R
T
T
D
----------
G
D
G
L
I
Y
K
T
P
L
A
E
L
K
Q
L
D
A
G
S
W
K
G
Q
-----------
E
Y
Q
Q
--------
E
T
I
P
T
L
L
E
A
I
E
V
I
S
Q
-
Y
---
G
M
G
L
N
L
E
L
K
P
C
------------
E
G
L
E
E
E
T
-
I
A
A
S
V
E
V
L
K
Q
H
W
P
-------
Q
D
-
L
P
L
L
F
S
S
F
N
Y
F
A
L
V
S
A
K
A
L
W
P
E
I
------------------------
A
R
G
Y
N
V
S
A
--
I
-
P
S
---
A
W
--
Q
E
R
----------
L
------
E
H
L
D
C
A
G
L
H
--
I
---
H
-----
Q
S
F
F
D
V
Q
Q
V
S
D
I
--
K
-
A
A
G
Y
K
V
L
A
F
T
I
N
D
-
E
S
-----
L
A
L
K
L
Y
N
Q
G
L
D
A
V
F
S
D
Y
P
Q
K
-------------
24
PsiBlast_CBE
72.65
31%
-1
- C5 -
4R7O
2
?
E:
[20-290]
-----
A
H
R
G
A
S
G
H
A
P
E
H
T
F
A
S
Y
D
L
V
K
-
K
M
K
A
D
Y
L
E
L
D
I
Q
L
T
K
D
G
Q
L
I
A
M
H
D
T
A
V
D
R
T
T
N
----------
G
T
G
E
V
R
D
K
T
L
S
E
I
K
S
L
D
A
G
S
W
F
N
K
-----------
A
Y
P
E
KAKQEYVG
Q
K
V
P
T
L
E
E
I
F
Q
-
K
Y
G
-
R
---
S
M
K
Y
Y
I
E
T
K
S
P
D
V
---
Y
------
P
G
M
E
E
K
L
-
L
----
A
L
L
E
K
Y
N
L
IG------
S
-
R
V
M
I
-
Q
S
F
S
K
D
S
L
K
K
I
H
S
I
N
K
N
I
P
L
V
Q
L
L
W
Y
Y
PNE
N
N
E
I
VEWSGITH
E
P
K
R
V
T
N
D
--
D
-
F
Q
---
E
I
--
K
K
Y
---------------------
A
V
G
I
G
P
N
L
RND
N
-----
G
D
L
I
I
N
E
S
Y
M
K
M
A
R
Q
-
N
G
L
L
-
I
H
P
Y
T
I
N
E
-
K
P
-----
D
M
R
L
L
M
K
W
G
A
T
G
M
F
T
N
Y
P
D
R
L
H
T
V
L
K
-------
25
PsiBlast_CBE
72.38
31%
5
- C5 -
4R7O
4
?
D:
[20-290]
-----
A
H
R
G
A
S
G
H
A
P
E
H
T
F
A
S
Y
D
L
V
K
-
K
M
K
A
D
Y
L
E
L
D
I
Q
L
T
K
D
G
Q
L
I
A
M
H
D
T
A
V
D
R
T
T
N
----------
G
T
G
E
V
R
D
K
T
L
S
E
I
K
S
L
D
A
G
S
W
F
N
K
-----------
A
Y
P
E
KAKQEYVG
Q
K
V
P
T
L
E
E
I
F
Q
-
K
Y
G
-
R
---
S
M
K
Y
Y
I
E
T
K
S
P
D
V
---
Y
------
P
G
M
E
E
K
L
-
L
----
A
L
L
E
K
Y
N
L
IG
Q
N
M
S
-
S
S
-
R
V
M
I
-
Q
S
F
S
K
D
S
L
K
K
I
H
S
I
N
K
N
I
P
L
V
Q
LLW
Y
Y
P
N
ENNEIVEWSGIT
H
E
P
K
R
V
T
N
D
--
D
-
F
Q
---
E
I
--
K
K
Y
---------------------
A
V
G
I
G
P
N
L
RND
N
-----
G
D
L
I
I
N
E
S
Y
M
K
M
A
R
Q
-
N
G
L
L
-
I
H
P
Y
T
I
N
E
-
K
P
-----
D
M
R
L
L
M
K
W
G
A
T
G
M
F
T
N
Y
P
D
R
L
H
T
V
L
K
-------
2
PsiBlast_PDB
72.37
31%
5
- C5 -
4R7O
7
?
A:
[20-290]
-----
A
H
R
G
A
S
G
H
A
P
E
H
T
F
A
S
Y
D
L
V
K
-
K
M
K
A
D
Y
L
E
L
D
I
Q
L
T
K
D
G
Q
L
I
A
M
H
D
T
A
V
D
R
T
T
N
----------
G
T
G
E
V
R
D
K
T
L
S
E
I
K
S
L
D
A
G
S
W
F
N
K
-----------
A
Y
P
E
KAKQEYVG
Q
K
V
P
T
L
E
E
I
F
Q
-
K
Y
G
-
R
---
S
M
K
Y
Y
I
E
T
K
S
P
D
V
---
Y
------
P
G
M
E
E
K
L
-
L
----
A
L
L
E
K
Y
N
L
IGQNMS-
S
S
-
R
V
M
I
-
Q
S
F
S
K
D
S
L
K
K
I
H
S
I
N
K
N
I
P
L
V
Q
L
L
W
Y
Y
P
N
ENN
E
I
V
E
WSGITH
E
P
K
R
V
T
N
D
--
D
-
F
Q
---
E
I
--
K
K
Y
---------------------
A
V
G
I
G
P
N
L
RND
N
-----
G
D
L
I
I
N
E
S
Y
M
K
M
A
R
Q
-
N
G
L
L
-
I
H
P
Y
T
I
N
E
-
K
P
-----
D
M
R
L
L
M
K
W
G
A
T
G
M
F
T
N
Y
P
D
R
L
H
T
V
L
K
-------
53
HHSearch
72.25
26%
-46
- C5 -
1ZCC
2
?
A:
[1-234]
M
T
K
I
V
S
H
R
G
A
N
R
F
A
P
E
N
T
F
A
A
A
D
L
A
L
-
Q
Q
G
A
D
Y
I
E
L
D
V
R
E
S
A
D
G
V
L
Y
V
I
H
D
E
T
L
D
R
T
T
N
----------
G
T
G
P
V
G
H
M
L
S
S
E
I
D
T
L
D
A
G
G
W
F
D
D
-----------
R
F
K
G
--------
A
I
V
P
R
L
D
A
Y
L
E
H
L
R
G
-----
R
A
G
V
Y
I
E
L
K
Y
C
D
P
--------------
A
-
K
-
V
A
---
A
L
V
R
H
L
G
M
-------
V
R
-
D
T
F
Y
-
F
S
F
S
E
E
M
R
Q
G
L
Q
S
I
A
P
E
F
------------------------
R
R
M
M
T
L
D
I
A-
K
S
P
S
---
L
V
--
G
A
V
-------------------
H
H
A
S
I
I
E
I
T
P
---
A
------
Q
M
R
R
P
G
I
I
E
A
S
--
R
K
A
G
-
L
E
I
M
V
Y
Y
G
G
D
D
M
A
-----
V
H
R
E
I
A
T
S
D
V
D
Y
I
N
L
D
R
P
D
L
F
A
A
V
R
S
G
------
55
HHSearch
72.13
33%
1
- C5 -
4R7O
7
?
A:
[15-291]
K
F
L
N
I
A
H
R
G
A
S
G
H
A
P
E
H
T
F
A
S
Y
D
L
V
K
-
K
M
K
A
D
Y
L
E
L
D
I
Q
L
T
K
D
G
Q
L
I
A
M
H
D
T
A
V
D
R
T
T
N
----------
G
T
G
E
V
R
D
K
T
L
S
E
I
K
S
L
D
A
G
S
W
F
N
K
A
Y
PEKAKQ---
E
Y
V
G
--------
Q
K
V
P
T
L
E
E
I
F
Q
K
Y
G
R
-----
S
M
K
Y
Y
I
E
T
K
S
P
D
V
---
Y
------
P
G
M
E
E
-
K
-
L
L
---
A
L
L
E
K
Y
N
L
IGQNMS-
S
S
-
R
V
M
I
-
Q
S
F
S
K
D
S
L
K
K
I
H
S
I
N
K
N
I
------------------------
P
L
V
Q
L
L
W
Y
Y
-
P
-
N
E
NN
E
I
V
--
E
W
S
GITHEPKRVT
N
D
D
F
Q
E
-
I
K
K
Y
A
V
G
I
G
P
N
L
---
R
NDNG-
D
L
I
I
N
E
S
Y
M
K
M
A
--
R
Q
N
G
-
L
L
I
H
P
Y
T
I
N
E
-
K
P
-----
D
M
R
L
L
M
K
W
G
A
T
G
M
F
T
N
Y
P
D
R
L
H
T
V
L
K
E
------
22
PsiBlast_CBE
71.72
31%
7
- C5 -
4R7O
7
?
G:
[20-290]
-----
A
H
R
G
A
S
G
H
A
P
E
H
T
F
A
S
Y
D
L
V
K
-
K
M
K
A
D
Y
L
E
L
D
I
Q
L
T
K
D
G
Q
L
I
A
M
H
D
T
A
V
D
R
T
T
N
----------
G
T
G
E
V
R
D
K
T
L
S
E
I
K
S
L
D
A
G
S
W
F
N
K
-----------
A
Y
P
E
KAKQEYVG
Q
K
V
P
T
L
E
E
I
F
Q
-
K
Y
G
-
R
---
S
M
K
Y
Y
I
E
T
K
S
P
D
V
---
Y
------
P
G
M
E
E
K
L
-
L
----
A
L
L
E
K
Y
N
L
I---------
R
V
M
I
-
Q
S
F
S
K
D
S
L
K
K
I
H
S
I
N
K
N
I
PLVQLLWYYPNENNEIVEWSGITH
E
P
K
R
V
T
N
D
--
D
-
F
Q
---
E
I
--
K
K
Y
---------------------
A
V
G
I
G
P
N
L
RND
N
-----
G
D
L
I
I
N
E
S
Y
M
K
M
AR
Q
-
N
G
L
L
-
I
H
P
Y
T
I
N
E
-
K
P
-----
D
M
R
L
L
M
K
W
G
A
T
G
M
F
T
N
Y
P
D
R
L
H
T
V
L
K
-------
27
PsiBlast_CBE
71.08
31%
6
- C5 -
4R7O
4
?
B:
[20-290]
-----
A
H
R
G
A
S
G
H
A
P
E
H
T
F
A
S
Y
D
L
V
K
-
K
M
K
A
D
Y
L
E
L
D
I
Q
L
T
K
D
G
Q
L
I
A
M
H
D
T
A
V
D
R
T
T
N
----------
G
T
G
E
V
R
D
K
T
L
S
E
I
K
S
L
D
A
G
S
W
F
N
K
-----------
A
Y
P
E
KAKQEYVG
Q
K
V
P
T
L
E
E
I
F
Q
-
K
Y
G
-
R
---
S
M
K
Y
Y
I
E
T
K
S
P
D
V
---
Y
------
P
G
M
E
E
K
L
-
L
----
A
L
L
E
K
Y
N
L
IGQNMS-
S
S
-
R
V
M
I
-
Q
S
F
S
K
D
S
L
K
K
I
H
S
I
N
K
N
I
P
L
V
Q
L
L
W
Y
Y
P
N
ENN
E
I
V
E
WSGITH
E
P
K
R
V
T
N
D
--
D
-
F
Q
---
E
I
--
K
K
Y
---------------------
A
V
G
I
G
P
N
L
RND
N
-----
G
D
L
I
I
N
E
S
Y
M
K
M
A
R
Q
-
N
G
L
L
-
I
H
P
Y
T
I
N
E
-
K
P
-----
D
M
R
L
L
M
K
W
G
A
T
G
M
F
T
N
Y
P
D
R
L
H
T
V
L
K
-------
26
PsiBlast_CBE
70.89
31%
5
- C5 -
4R7O
6
?
C:
[20-290]
-----
A
H
R
G
A
S
G
H
A
P
E
H
T
F
A
S
Y
D
L
V
K
-
K
M
K
A
D
Y
L
E
L
D
I
Q
L
T
K
D
G
Q
L
I
A
M
H
D
T
A
V
D
R
T
T
N
----------
G
T
G
E
V
R
D
K
T
L
S
E
I
K
S
L
D
A
G
S
W
F
N
K
-----------
A
Y
P
E
KAKQEYVG
Q
K
V
P
T
L
E
E
I
F
Q
-
K
Y
G
-
R
---
S
M
K
Y
Y
I
E
T
K
S
P
D
V
---
Y
------
P
G
M
E
E
K
L
-
L
----
A
L
L
E
K
Y
N
L
IGQN
M
S
-
S
S
-
R
V
M
I
-
Q
S
F
S
K
D
S
L
K
K
I
H
S
I
N
K
N
I
P
L
V
Q
L
L
WYY
P
N
E
N
NEIVEWSGITH
E
P
K
R
V
T
N
D
--
D
-
F
Q
---
E
I
--
K
K
Y
---------------------
A
V
G
I
G
P
N
L
RND
N
-----
G
D
L
I
I
N
E
S
Y
M
K
M
A
R
Q
-
N
G
L
L
-
I
H
P
Y
T
I
N
E
-
K
P
-----
D
M
R
L
L
M
K
W
G
A
T
G
M
F
T
N
Y
P
D
R
L
H
T
V
L
K
-------
23
PsiBlast_CBE
70.67
31%
10
- C5 -
4R7O
2
?
F:
[20-290]
-----
A
H
R
G
A
S
G
H
A
P
E
H
T
F
A
S
Y
D
L
V
K
-
K
M
K
A
D
Y
L
E
L
D
I
Q
L
T
K
D
G
Q
L
I
A
M
H
D
T
A
V
D
R
T
T
N
----------
G
T
G
E
V
R
D
K
T
L
S
E
I
K
S
L
D
A
G
S
W
F
N
K
-----------
A
Y
P
E
KAKQEYVG
Q
K
V
P
T
L
E
E
I
F
Q
-
K
Y
G
-
R
---
S
M
K
Y
Y
I
E
T
K
S
P
D
V
---
Y
------
P
G
M
E
E
K
L
-
L
----
A
L
L
E
K
Y
N
L
I---------
R
V
M
I
-
Q
S
F
S
K
D
S
L
K
K
I
H
S
I
N
K
N
I
PLVQLLWYYPNENNEIVEWSGITH
E
P
K
R
V
T
N
D
--
D
-
F
Q
---
E
I
--
K
K
Y
---------------------
A
V
G
I
G
P
N
L
RND
N
-----
G
D
L
I
I
N
E
S
Y
M
K
M
AR
Q
-
N
G
L
L
-
I
H
P
Y
T
I
N
E
-
K
P
-----
D
M
R
L
L
M
K
W
G
A
T
G
M
F
T
N
Y
P
D
R
L
H
T
V
L
K
-------
70
Fugue
70.18
25%
-71
- C5 -
1ZCC
2
?
A:
[1-240]
M
T
K
I
V
S
H
R
G
A
N
R
F
A
P
E
N
T
F
A
A
A
D
L
A
L
-
Q
Q
G
A
D
Y
I
E
L
D
V
R
E
S
A
D
G
V
L
Y
V
I
H
D
E
T
L
D
R
T
T
N
----------
G
T
G
P
V
G
H
M
L
S
S
E
I
D
T
L
D
A
G
G
W
F
D
D
-----------
R
F
K
G
--------
A
I
V
P
R
L
D
A
Y
L
E
H
L
-
R
-
G
---
R
A
G
V
Y
I
E
L
K
Y
C
D
--------------
P
A
K
V
-
A
----
A
L
V
R
H
L
G
M
-------
V
R
-
D
T
F
Y
-
F
S
F
S
E
E
M
R
Q
G
L
Q
S
I
A
P
E
F
------------------------
R
R
M
M
T
L
D
I
--
A
-
K
S
---
P
S
--
L
V
G
----------
A
------
V
H
H
A
S
I
I
E
I
T
-----
P
-----
A
Q
M
R
R
P
G
I
I
E
A
S
--
R
-
K
A
G
L
E
I
M
V
Y
Y
G
G
D
D
M
A
-----
V
H
R
E
I
A
T
S
D
V
D
Y
I
N
L
D
R
P
D
L
F
A
A
V
R
S
G
M
A
E
L
L
L
59
HHSearch
69.28
28%
1
- C5 -
3L12
5
?
A:
[17-307]
V
V
R
V
I
G
H
R
G
A
R
G
V
M
P
E
N
T
L
E
G
F
A
F
T
L
-
A
A
G
V
R
A
L
E
F
D
V
V
M
T
A
D
G
V
P
V
V
T
H
N
H
H
L
A
N
A
M
T
RDGQGHWLTG
A
E
R
Q
V
A
E
M
T
Y
A
E
I
R
A
L
D
V
G
G
L
D
G
R
T
V
Y
G
R
R
F
PD
Q
A
F
L
T
G
--------
I
H
V
P
R
L
G
E
L
L
D
L
C
A
G
-
Y
GDQ
A
P
Y
L
L
L
E
L
K
S
D
P
A
L
--
M
HD
H
A
A
R
A
E
M
V
A
-
A
-
V
L
---
A
D
V
R
R
Y
R
M
-------
E
P
-
R
T
V
M
-
H
S
F
D
W
A
L
L
G
E
C
R
R
Q
A
P
D
L
------------------------
P
T
S
Y
L
S
Q
L
P-
E
---GPD
Y
D
--
R
M
T
----------
E
S
L
P
Q
A
V
A
S
A
G
G
Q
L
W
C
P
Y
F
----------
L
D
V
T
P
E
L
V
A
E
A
--
H
D
L
G
-
L
I
V
L
T
W
T
V
N
E
-
P
E
-----
D
I
R
R
M
A
T
T
G
V
D
G
I
V
T
D
Y
P
G
R
T
Q
R
I
L
I
D
------
51
HHSearch
67.91
23%
-37
- C5 -
3KS6
7
?
A:
[2-243]
M
T
R
I
A
S
H
R
G
G
T
L
E
F
G
D
S
T
P
H
G
F
T
A
T
A
-
A
M
A
L
E
E
V
E
F
D
L
H
P
T
A
D
G
A
I
V
V
H
H
D
P
T
L
D
A
T
T
D
----------
M
T
G
A
I
V
D
M
T
L
A
K
V
K
T
A
T
I
R
Y
G
----------------
A
G
--------
S
H
P
M
T
L
E
E
L
C
A
L
Y
V
D
-
S
---
H
V
N
F
R
C
E
I
K
P
G
V
D
G
LP
Y
------
E
G
F
V
A
-
L
-
V
I
---
A
G
L
E
R
H
S
M
-------
L
E
-
R
T
T
F
-
S
S
F
L
L
A
S
M
D
E
L
W
K
A
T
T
R
P
------------------------
R
L
W
L
V
S
P
S
V
-
L
-
Q
Q
---
L
G
P
G
A
V
I
----------
E
T
A
----
I
A
H
S
I
H
E
I
G
V
H
I
----------
D
T
A
D
A
G
L
M
A
Q
V
--
Q
A
A
G
-
L
D
F
G
C
W
A
A
H
T
-
P
S
-----
Q
I
T
K
A
L
D
L
G
V
K
V
F
T
T
D
R
P
T
L
A
I
A
L
R
T
E
------
7
PsiBlast_PDB
67.71
26%
-36
- C5 -
2OTD
1
?
A:
[8-235]
--
R
I
V
A
H
R
G
G
G
K
L
A
P
E
N
T
L
A
A
I
D
V
G
A
-
K
Y
G
H
K
M
I
E
F
D
A
K
L
S
K
D
G
E
I
F
L
L
H
D
D
N
L
E
R
T
S
N
----------
G
W
G
V
A
G
E
L
N
W
Q
D
L
L
R
V
D
A
G
S
W
Y
S
K
-----------
A
F
K
G
--------
E
P
L
P
L
L
S
Q
V
A
E
R
C
R
E
-
H
---
G
M
M
A
N
I
E
I
K
P
T
T
G
T
--
G
------
P
L
T
G
K
M
V
A
L
----
A
A
R
Q
L
W
A
G
-------
M
T
-
P
P
L
L
-
S
S
F
E
I
D
A
L
E
A
A
Q
Q
A
A
P
E
L
------------------------
P
R
G
L
L
L
D
E
--
W
-
R
D
---
D
W
--
R
E
L
----------
T
------
A
R
L
G
C
V
S
I
H
--
L
---
N
-----
H
K
L
L
D
K
A
R
V
M
Q
L
--
K
-
D
A
G
L
R
I
L
V
Y
T
V
N
K
-
P
Q
-----
H
A
A
E
L
L
R
W
G
V
D
C
I
C
T
D
-----------------
54
HHSearch
67.27
32%
-21
- C5 -
4OEC
1
?
A:
[6-244]
R
V
I
V
L
G
H
R
G
Y
M
S
N
Y
P
E
N
T
L
L
A
F
R
K
A
V
-
E
A
G
A
D
G
I
E
L
D
V
W
L
T
K
D
G
R
V
V
V
M
H
D
E
T
I
D
R
T
S
N
----------
M
K
G
R
Q
K
D
M
T
L
E
E
L
K
K
A
D
V
G
Q
------------------
G
--------
E
R
I
P
T
L
E
E
V
F
E
A
I
P
R
-----
N
A
L
V
N
V
E
L
K
D
R
D
A
-------------
A
R
-
E
-
V
A
---
E
I
V
A
E
N
N
--------
P
E
-
R
V
M
I
-
S
S
F
D
I
D
A
L
R
E
Y
R
K
Y
D
D
E
T
------------------------
T
M
G
L
L
I
D
R
E-
E
V
V
P
L--
I
P
--
K
L
K
-----------------
D
E
L
N
L
W
S
V
N
V
P
M
---
E
AIPLI
G
L
E
K
T
L
Q
A
L
H
W
V
--
R
S
L
G
-
L
K
V
V
L
W
T
E
N
D
-
V
L
FYKDD
N
L
A
K
L
K
G
-
L
F
E
V
V
I
A
N
D
V
V
R
M
I
E
Y
L
K
K
------
58
HHSearch
66.58
36%
49
- C5 -
2OOG
10
?
A:
[23-279]
R
F
T
T
I
A
H
R
G
A
S
G
Y
A
P
E
H
T
F
Q
A
Y
D
K
S
H
N
E
L
K
A
S
Y
I
E
I
D
L
Q
R
T
K
D
G
H
L
V
A
M
H
D
E
T
V
N
R
T
T
N
----------
G
H
G
K
V
E
D
Y
T
L
D
E
L
K
Q
L
D
A
G
S
W
F
N
K
K
Y
PKYARA---
S
Y
K
N
--------
A
K
V
P
T
L
D
E
I
L
E
R
Y
G
P
-----
N
A
N
Y
Y
I
E
T
K
S
P
D
V
---
Y
------
P
G
M
E
E
-
Q
-
L
L
---
A
S
L
K
K
H
H
L
LN
N
N
K
L
K
N
G
-
H
V
M
I
-
Q
S
F
S
D
E
S
L
K
K
I
H
R
Q
N
K
H
V
------------------------
P
L
V
K
L
V
D
K
GE
L
-
Q
Q
---
F
N
D
-
Q
R
L
----------
K
E
-----
I
R
S
Y
A
I
G
L
G
P
D
Y
----------
T
D
L
T
E
Q
N
T
H
H
L
--
K
D
L
G
-
F
I
V
H
P
Y
T
V
N
E
-
K
A
-----
D
M
L
R
L
N
K
Y
G
V
D
G
V
F
T
N
F
A
D
K
Y
K
E
V
I
K
-------
62
HHSearch
62.21
31%
-4
- C5 -
1VD6
1
?
A:
[7-223]
R
P
L
R
L
G
H
R
G
A
P
L
K
A
K
E
N
T
L
E
S
F
R
L
A
L
-
E
A
G
L
D
G
V
E
L
D
V
W
P
T
R
D
G
V
F
A
V
R
H
D
P
D
T
P
---------------
L
G
P
V
F
Q
V
D
Y
A
D
L
K
A
Q
----------------------
E
--------
P
D
L
P
R
L
E
E
V
L
A
L
K
E
A
F
P
---
Q
A
V
F
N
V
E
L
K
S
F
P
G
L
--
G
------
E
E
A
A
R
-
R
-
L
A
---
A
L
L
R
G
----------
R
E
-
G
V
W
V
-
S
S
F
D
P
L
A
L
L
A
L
R
K
A
A
P
G
L
------------------------
P
L
G
F
L
M
A
E
D-
H
-
S
A
---
L
-----
L
-----------------
P
C
L
G
V
E
A
V
H
P
H
H
----------
A
L
V
T
E
E
A
V
A
G
W
--
R
K
R
G
-
L
F
V
V
A
W
T
V
N
E
-
E
G
-----
E
A
R
R
L
L
A
L
G
L
D
G
L
I
G
D
R
P
E
V
L
L
P
L
G
--------