@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu24310: (2016-07-08 )
MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDPASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPDHISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKEVVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISADQIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVKSAKRTLS
Atome Classification :
(34 SA)
.........10........20......-.--.--30-........40........50........60.-.......70........80........90........100..--.-......110.......120.......130.-.--.--.-..-.140.......150......---.160.......170.......--180.........190.--......200.......210.......220.......230-----...-----...------..240.......250.......260.......270.......280.----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
A
T
IID
G
K
E
T
A
R
E
K
R
E
Q
L
A
K
E
V
E
E
L
K
-K--Q--GV-TP
G
L
A
V
I
L
IGDDPASH
S
Y
VRG
K
K
K
A
A
E
TMGM-
N
F
K
L
D
Q
FDSSL
T
E
A
E
L
L
S
I
I
D
Q
YNQDPEF
H
G
I
L
V
QLPL--PD--H-
I
S
E
K
A
V
I
E
RISPDKDVDGFHPLN
V
G
K
M
LLG-E--D--T-FL-PCT
P
H
G
I
V
E
L
L
K
KTNIDLSG---
K
E
V
V
V
VGRSNIVGK
P
V
G
Q
L
LL--N--EN
A
T
V
T
Y
CHSRTE--
N
I
T
E
HTKKA
D
I
L
V
V
A
VGRANFI
S
A
D
QIKEG
A
V
V
I
DVGV------NRL-----ENG------
K
L
CGDVEFEGAKEKA
S
F
ITPVPGGVG
P
M
T
I
T
M
LAH
N
T
V
K
S
A
K
RTLS----
46
HHSearch
87.27
51%
-57
* C4 *
3P2O
2
FOLD_CAMJE
A:
[2-284]
N
A
M
T
L
L
D
G
K
A
L
S
A
K
I
K
E
E
L
K
E
K
N
Q
F
L
K
-
S
--
K
--
G
I
-
E
S
C
L
A
V
I
L
V
G
D
N
P
A
S
Q
T
Y
V
K
S
K
A
K
A
C
E
E
C
G
I
-
K
S
L
V
Y
H
L
N
E
N
I
T
Q
N
E
L
L
A
L
I
N
T
L
N
H
D
D
S
V
H
G
I
L
V
Q
L
P
L
--
P
D
--
H
-
I
C
K
D
L
I
L
E
S
I
I
S
S
K
D
V
D
G
F
H
P
I
N
V
G
Y
L
N
L
G
-
L
E-
S
--
G
-
F
L
-
P
C
T
P
L
G
V
M
K
L
L
K
A
Y
E
I
D
L
E
G
---
K
D
A
V
I
I
G
A
S
N
I
V
G
R
P
M
A
T
M
L
L
--
N
--
A
G
A
T
V
S
V
C
H
I
K
T
K
--
D
L
S
L
Y
T
R
Q
A
D
L
I
I
V
A
A
G
C
V
N
L
L
R
S
D
M
V
K
E
G
V
I
V
V
D
V
G
I
------
N
R
L
-----
E
S
G
------
K
I
V
G
D
V
D
F
E
E
V
S
K
K
S
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
V
K
S
A
K
N
R
L
-----
1
PsiBlast_PDB
86.86
50%
-57
- C4 -
3P2O
2
FOLD_CAMJE
A:
[5-284]
---
T
L
L
D
G
K
A
L
S
A
K
I
K
E
E
L
K
E
K
N
Q
F
L
K
-
S
--
K
--
G
I
-
E
S
C
L
A
V
I
L
V
G
D
N
P
A
S
Q
T
Y
V
K
S
K
A
K
A
C
E
E
C
G
I
-
K
S
L
V
Y
H
L
N
E
N
I
T
Q
N
E
L
L
A
L
I
N
T
L
N
H
D
D
S
V
H
G
I
L
V
Q
L
P
L
--
P
D
--
H
-
I
C
K
D
L
I
L
E
S
I
I
S
S
K
D
V
D
G
F
H
P
I
N
V
G
Y
L
N
L
G
L
E
--
S
--
G
-
F
L
-
P
C
T
P
L
G
V
M
K
L
L
K
A
Y
E
I
D
L
E
G
---
K
D
A
V
I
I
G
A
S
N
I
V
G
R
P
M
A
T
M
L
L
--
N
--
A
G
A
T
V
S
V
C
H
I
K
T
K
--
D
L
S
L
Y
T
R
Q
A
D
L
I
I
V
A
A
G
C
V
N
L
L
R
S
D
M
V
K
E
G
V
I
V
V
D
V
G
I
------
N
R
L
-----
E
S
G
------
K
I
V
G
D
V
D
F
E
E
V
S
K
K
S
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
V
K
S
A
K
N
R
L
-----
3
PsiBlast_PDB
84.12
51%
-25
- C4 -
1B0A
-
FOLD_ECOLI
A:
[2-279]
-
A
A
K
I
I
D
G
K
T
I
A
Q
Q
V
R
S
E
V
A
Q
K
V
Q
A
R
I
-
A
--
A
--
G
L
R
A
P
G
L
A
V
V
L
V
G
S
N
P
A
S
Q
I
Y
V
A
S
K
R
K
A
C
E
E
V
G
F
-
V
S
R
S
Y
D
L
P
E
T
T
S
E
A
E
L
L
E
L
I
D
T
L
N
A
D
N
T
I
D
G
I
L
V
Q
L
P
L
--
P
A
--
G
-
I
D
N
V
K
V
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
V
G
R
L
C
Q
R
-
A
--
P
--
R
-
L
R
-
P
C
T
P
R
G
I
V
T
L
L
E
R
Y
N
I
D
T
F
G
---
L
N
A
V
V
I
G
A
S
N
I
V
G
R
P
M
S
M
E
L
L
--
L
--
A
G
C
T
T
T
V
T
H
R
F
T
K
--
N
L
R
H
H
V
E
N
A
D
L
L
I
V
A
V
G
K
P
G
F
I
P
G
D
W
I
K
E
G
A
I
V
I
D
V
G
I
------
N
R
L
-----
E
N
G
------
K
V
V
G
D
V
V
F
E
D
A
A
K
R
A
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
V
A
T
L
I
E
N
T
L
Q
A
C
---------
49
HHSearch
84.07
52%
-4
- C4 -
3L07
4
FOLD_FRATT
A:
[3-283]
-
A
M
I
L
I
D
G
K
S
L
S
K
D
L
K
E
R
L
A
T
Q
V
Q
E
Y
K
-
H
H
-
T
--
A
I
-
T
P
K
L
V
A
I
I
V
G
N
D
P
A
S
K
T
Y
V
A
S
K
E
K
A
C
A
Q
V
G
I
-
D
S
Q
V
I
T
L
P
E
H
T
T
E
S
E
L
L
E
L
I
D
Q
L
N
N
D
S
S
V
H
A
I
L
V
Q
L
P
L
--
P
A
--
H
-
I
N
K
N
N
V
I
Y
S
I
K
P
E
K
D
V
D
G
F
H
P
T
N
V
G
R
L
Q
L
R
-
D
K-
K
--
C
-
L
E
-
S
C
T
P
K
G
I
M
T
M
L
R
E
Y
G
I
K
T
E
G
---
A
Y
A
V
V
V
G
A
S
N
V
V
G
K
P
V
S
Q
L
L
L
--
N
--
A
K
A
T
V
T
T
C
H
R
F
T
T
--
D
L
K
S
H
T
T
K
A
D
I
L
I
V
A
V
G
K
P
N
F
I
T
A
D
M
V
K
E
G
A
V
V
I
D
V
G
I
------
N
H
V
-----
D
-
G
------
K
I
V
G
D
V
D
F
A
A
V
K
D
K
V
A
A
I
T
P
V
P
G
G
V
G
P
M
T
I
T
E
L
L
Y
N
T
F
Q
C
A
Q
E
L
------
51
HHSearch
83.88
51%
-24
- C4 -
1B0A
-
FOLD_ECOLI
A:
[2-282]
-
A
A
K
I
I
D
G
K
T
I
A
Q
Q
V
R
S
E
V
A
Q
K
V
Q
A
R
I
-
A
A
-
G
--
L
R
-
A
P
G
L
A
V
V
L
V
G
S
N
P
A
S
Q
I
Y
V
A
S
K
R
K
A
C
E
E
V
G
F
-
V
S
R
S
Y
D
L
P
E
T
T
S
E
A
E
L
L
E
L
I
D
T
L
N
A
D
N
T
I
D
G
I
L
V
Q
L
P
L
--
P
A
--
G
-
I
D
N
V
K
V
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
V
G
R
L
C
Q
R
-
A
--
P
--
R
-
L
R
-
P
C
T
P
R
G
I
V
T
L
L
E
R
Y
N
I
D
T
F
G
---
L
N
A
V
V
I
G
A
S
N
I
V
G
R
P
M
S
M
E
L
L
--
L
--
A
G
C
T
T
T
V
T
H
R
F
T
K
--
N
L
R
H
H
V
E
N
A
D
L
L
I
V
A
V
G
K
P
G
F
I
P
G
D
W
I
K
E
G
A
I
V
I
D
V
G
I
------
N
R
L
-----
E
N
G
------
K
V
V
G
D
V
V
F
E
D
A
A
K
R
A
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
V
A
T
L
I
E
N
T
L
Q
A
C
V
E
Y
------
21
PsiBlast_CBE
83.74
53%
-8
- C4 -
3L07
4
FOLD_FRATT
B:
[6-281]
----
L
I
D
G
K
S
L
S
K
D
L
K
E
R
L
A
T
Q
V
Q
E
Y
K
-
H
--
H
T-
A
I
-
T
P
K
L
V
A
I
I
V
G
N
D
P
A
S
K
T
Y
V
A
S
K
E
K
A
C
A
Q
V
G
I
-
D
S
Q
V
I
T
L
P
E
H
T
T
E
S
E
L
L
E
L
I
D
Q
L
N
N
D
S
S
V
H
A
I
L
V
Q
L
P
L
--
P
A
--
H
-
I
N
K
N
N
V
I
Y
S
I
K
P
E
K
D
V
D
G
F
H
P
T
N
V
G
R
L
Q
L
R
-
D
--
K
--
K
-
C
L
E
S
C
T
P
K
G
I
M
T
M
L
R
E
Y
G
I
K
T
E
G
---
A
Y
A
V
V
V
G
A
S
N
V
V
G
K
P
V
S
Q
L
L
L
--
N
--
A
K
A
T
V
T
T
C
H
R
F
T
T
--
D
L
K
S
H
T
T
K
A
D
I
L
I
V
A
V
G
K
P
N
F
I
T
A
D
M
V
K
E
G
A
V
V
I
D
V
G
I
------
N
H
V
-----
D
-
G
------
K
I
V
G
D
V
D
F
A
A
V
K
D
K
V
A
A
I
T
P
V
P
G
G
V
G
P
M
T
I
T
E
L
L
Y
N
T
F
Q
C
A
Q
--------
2
PsiBlast_PDB
83.40
53%
-5
- C4 -
3L07
4
FOLD_FRATT
A:
[6-281]
----
L
I
D
G
K
S
L
S
K
D
L
K
E
R
L
A
T
Q
V
Q
E
Y
K
-
H
--
H
T-
A
I
-
T
P
K
L
V
A
I
I
V
G
N
D
P
A
S
K
T
Y
V
A
S
K
E
K
A
C
A
Q
V
G
I
-
D
S
Q
V
I
T
L
P
E
H
T
T
E
S
E
L
L
E
L
I
D
Q
L
N
N
D
S
S
V
H
A
I
L
V
Q
L
P
L
--
P
A
--
H
-
I
N
K
N
N
V
I
Y
S
I
K
P
E
K
D
V
D
G
F
H
P
T
N
V
G
R
L
Q
L
R
-
D
--
K
--
K
-
C
L
E
S
C
T
P
K
G
I
M
T
M
L
R
E
Y
G
I
K
T
E
G
---
A
Y
A
V
V
V
G
A
S
N
V
V
G
K
P
V
S
Q
L
L
L
--
N
--
A
K
A
T
V
T
T
C
H
R
F
T
T
--
D
L
K
S
H
T
T
K
A
D
I
L
I
V
A
V
G
K
P
N
F
I
T
A
D
M
V
K
E
G
A
V
V
I
D
V
G
I
------
N
H
V
-----
D
-
G
------
K
I
V
G
D
V
D
F
A
A
V
K
D
K
V
A
A
I
T
P
V
P
G
G
V
G
P
M
T
I
T
E
L
L
Y
N
T
F
Q
C
A
Q
--------
12
PsiBlast_PDB
83.27
45%
-67
- C4 -
2C2X
-
FOLD_MYCTU
A:
[3-280]
--
A
I
M
L
D
G
K
A
T
R
D
E
I
F
G
D
L
K
Q
R
V
A
A
L
D
-
A
--
A
--
G
R
-
T
P
G
L
G
T
I
L
V
G
D
D
P
G
S
Q
A
Y
V
R
G
K
H
A
D
C
A
K
V
G
I
-
T
S
I
R
R
D
L
P
A
D
I
S
T
A
T
L
N
E
T
I
D
E
L
N
A
N
P
D
C
T
G
Y
I
V
Q
L
P
L
--
P
K
--
H
-
L
D
E
N
A
A
L
E
R
V
D
P
A
K
D
A
D
G
L
H
P
T
N
L
G
R
L
V
L
G
-
T
--
P
--
A
-
P
L
-
P
C
T
P
R
G
I
V
H
L
L
R
R
Y
D
I
S
I
A
G
---
A
H
V
V
V
I
G
R
G
V
T
V
G
R
P
L
G
L
L
L
T
RR
S
--
E
N
A
T
V
T
L
C
H
T
G
T
R
--
D
L
P
A
L
T
R
Q
A
D
I
V
V
A
A
V
G
V
A
H
L
L
T
A
D
M
V
R
P
G
A
A
V
I
D
V
G
V
------
S
R
T
-----
D
D
G
-------
L
V
G
D
V
H
P
D
-
V
W
E
L
A
G
H
V
S
P
N
P
G
G
V
G
P
L
T
R
A
F
L
L
T
N
V
V
E
L
A
E
R
-------
33
Fugue
82.98
51%
2
- C4 -
1B0A
-
FOLD_ECOLI
A:
[2-288]
-
A
A
K
I
I
D
G
K
T
I
A
Q
Q
V
R
S
E
V
A
Q
K
V
Q
A
R
I
-
A
--
A
G-
L
R
-
A
P
G
L
A
V
V
L
V
G
S
N
P
A
S
Q
I
Y
V
A
S
K
R
K
A
C
E
E
V
G
F
-
V
S
R
S
Y
D
L
P
E
T
T
S
E
A
E
L
L
E
L
I
D
T
L
N
A
D
N
T
I
D
G
I
L
V
Q
L
P
L
--
P
A
---G
I
D
N
V
K
V
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
V
G
R
L
C
Q
R
-
A
--
P
---R
L
R
-
P
C
T
P
R
G
I
V
T
L
L
E
R
Y
N
I
D
T
F
G
---
L
N
A
V
V
I
G
A
S
N
I
V
G
R
P
M
S
M
E
L
L
--
L
--
A
G
C
T
T
T
V
T
H
R
F
T
K
--
N
L
R
H
H
V
E
N
A
D
L
L
I
V
A
V
G
K
P
G
F
I
P
G
D
W
I
K
E
G
A
I
V
I
D
V
G
I
------
N
R
L
-----
E
N
G
------
K
V
V
G
D
V
V
F
E
D
A
A
K
R
A
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
V
A
T
L
I
E
N
T
L
Q
A
C
V
E
Y
H
D
PQDE
45
HHSearch
82.70
46%
-66
- C4 -
2C2X
-
FOLD_MYCTU
A:
[2-280]
-
G
A
I
M
L
D
G
K
A
T
R
D
E
I
F
G
D
L
K
Q
R
V
A
A
L
D
-
A
--
A
--
G
R
-
T
P
G
L
G
T
I
L
V
G
D
D
P
G
S
Q
A
Y
V
R
G
K
H
A
D
C
A
K
V
G
I
-
T
S
I
R
R
D
L
P
A
D
I
S
T
A
T
L
N
E
T
I
D
E
L
N
A
N
P
D
C
T
G
Y
I
V
Q
L
P
L
--
P
K
--
H
-
L
D
E
N
A
A
L
E
R
V
D
P
A
K
D
A
D
G
L
H
P
T
N
L
G
R
L
V
L
G
-
T
--
P
--
A
-
P
L
-
P
C
T
P
R
G
I
V
H
L
L
R
R
Y
D
I
S
I
A
G
---
A
H
V
V
V
I
G
R
G
V
T
V
G
R
P
L
G
L
L
L
T
--
R
RS
E
N
A
T
V
T
L
C
H
T
G
T
R
--
D
L
P
A
L
T
R
Q
A
D
I
V
V
A
A
V
G
V
A
H
L
L
T
A
D
M
V
R
P
G
A
A
V
I
D
V
G
V
------
S
R
T
-----
D
-
D
------
G
L
V
G
D
V
H
P
D
-
V
W
E
L
A
G
H
V
S
P
N
P
G
G
V
G
P
L
T
R
A
F
L
L
T
N
V
V
E
L
A
E
R
-------
11
PsiBlast_PDB
82.69
46%
22
- C4 -
1A4I
1
C1TC_HUMAN
A:
[4-295]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
-
E
--
Q
V
P
G
F
-
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
-
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
A
R
G
-
D
LN
D
--
C
-
F
I
-
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
---
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
--
W
--
N
N
A
T
V
T
T
C
H
S
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y
---------------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
-----
6
PsiBlast_PDB
82.60
48%
-15
- C4 -
4B4V
4
?
A:
[23-302]
--
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
K
--
T
--
G
R
-
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
-
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
A
--
Q
-
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
A
M
G
-
E
--
A
--
A
-
Y
G
-
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
---
K
H
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
--
Q
--
A
N
A
T
V
T
I
C
H
S
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
P
R
-----
D
G
G
------
G
V
-
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
A
L
-----
24
PsiBlast_CBE
82.42
48%
-12
- C4 -
4B4U
7
?
B:
[23-302]
--
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
K
--
T
--
G
R
-
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
-
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
A
--
Q
-
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
A
M
G
-
E
--
A
--
A
-
Y
G
-
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
---
K
H
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
--
Q
--
A
N
A
T
V
T
I
C
H
S
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
P
R
-----
D
G
G
------
G
V
-
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
A
L
-----
44
HHSearch
82.19
49%
-19
- C4 -
4A5O
2
FOLD_PSEAE
A:
[4-285]
-
T
A
Q
L
I
D
G
K
A
I
A
A
N
L
R
Q
Q
I
A
Q
R
V
T
E
R
R
-
Q
Q
-
G
--
L
R
-
V
P
G
L
A
V
I
L
V
G
T
D
P
A
S
Q
V
Y
V
A
H
K
R
K
D
C
E
E
V
G
F
-
L
S
Q
A
Y
D
L
P
A
E
T
S
Q
D
D
L
L
A
L
I
D
R
L
N
D
D
P
A
I
D
G
I
L
V
Q
L
P
L
--
P
A
--
H
-
L
D
A
S
L
L
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
I
G
R
L
A
Q
R
-
M
--
P
--
L
-
L
R
-
P
C
T
P
K
G
I
M
T
L
L
A
S
T
G
A
D
L
Y
G
---
M
D
A
V
V
V
G
A
S
N
I
V
G
R
P
M
A
L
E
L
L
--
L
--
G
G
C
T
V
T
V
T
H
R
F
T
R
--
D
L
A
D
H
V
S
R
A
D
L
V
V
V
A
A
G
K
P
G
L
V
K
G
E
W
I
K
E
G
A
I
V
I
D
V
G
I
------
N
R
Q
-----
A
D
G
------
R
L
V
G
D
V
E
Y
E
V
A
A
Q
R
A
S
W
I
T
P
V
P
G
G
V
G
P
M
T
R
A
C
L
L
E
N
T
L
H
A
A
E
H
L
H
-----
10
PsiBlast_PDB
82.10
46%
20
- C4 -
1DIG
2
C1TC_HUMAN
A:
[4-295]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
-
E
--
Q
VP
G
F
-
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
-
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
A
R
G
-
D
LN
D
--
C
-
F
I
-
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
---
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
--
W
--
N
N
A
T
V
T
T
C
H
S
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y
---------------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
-----
8
PsiBlast_PDB
82.02
46%
20
- C4 -
1DIA
2
C1TC_HUMAN
A:
[4-295]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
-
E
--
Q
VP
G
F
-
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
-
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
A
R
G
-
D
LN
D
--
C
-
F
I
-
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
---
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
--
W
--
N
N
A
T
V
T
T
C
H
S
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y
---------------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
-----
23
PsiBlast_CBE
81.98
48%
-9
- C4 -
4B4V
3
?
B:
[23-302]
--
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
K
--
T
--
G
R
-
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
-
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
A
--
Q
-
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
A
M
G
-
E
--
A
--
A
-
Y
G
-
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
---
K
H
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
--
Q
--
A
N
A
T
V
T
I
C
H
S
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
P
R
-----
D
G
G
------
G
V
-
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
A
L
-----
13
PsiBlast_PDB
81.93
45%
-62
- C4 -
2C2Y
-
FOLD_MYCTU
A:
[3-280]
--
A
I
M
L
D
G
K
A
T
R
D
E
I
F
G
D
L
K
Q
R
V
A
A
L
D
-
A
--
A
--
G
R
-
T
P
G
L
G
T
I
L
V
G
D
D
P
G
S
Q
A
Y
V
R
G
K
H
A
D
C
A
K
V
G
I
-
T
S
I
R
R
D
L
P
A
D
I
S
T
A
T
L
N
E
T
I
D
E
L
N
A
N
P
D
C
T
G
Y
I
V
Q
L
P
L
--
P
K
--
H
-
L
D
E
N
A
A
L
E
R
V
D
P
A
K
D
A
D
G
L
H
P
T
N
L
G
R
L
V
L
G
-
T
--
P
--
A
-
P
L
-
P
C
T
P
R
G
I
V
H
L
L
R
R
Y
D
I
S
I
A
G
---
A
H
V
V
V
I
G
R
G
V
T
V
G
R
P
L
G
L
L
L
T
RR
S
--
E
N
A
T
V
T
L
C
H
T
G
T
R
--
D
L
P
A
L
T
R
Q
A
D
I
V
V
A
A
V
G
V
A
H
L
L
T
A
D
M
V
R
P
G
A
A
V
I
D
V
G
V
------
S
R
T
-----
D
D
G
-------
L
V
G
D
V
H
P
D
-
V
W
E
L
A
G
H
V
S
P
N
P
G
G
V
G
P
L
T
R
A
F
L
L
T
N
V
V
E
L
A
E
R
-------
4
PsiBlast_PDB
81.93
49%
-19
- C4 -
4A5O
2
FOLD_PSEAE
A:
[4-282]
-
T
A
Q
L
I
D
G
K
A
I
A
A
N
L
R
Q
Q
I
A
Q
R
V
T
E
R
R
-
Q
--
Q
--
G
L
R
V
P
G
L
A
V
I
L
V
G
T
D
P
A
S
Q
V
Y
V
A
H
K
R
K
D
C
E
E
V
G
F
-
L
S
Q
A
Y
D
L
P
A
E
T
S
Q
D
D
L
L
A
L
I
D
R
L
N
D
D
P
A
I
D
G
I
L
V
Q
L
P
L
--
P
A
--
H
-
L
D
A
S
L
L
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
I
G
R
L
A
Q
R
-
M
--
P
--
L
-
L
R
-
P
C
T
P
K
G
I
M
T
L
L
A
S
T
G
A
D
L
Y
G
---
M
D
A
V
V
V
G
A
S
N
I
V
G
R
P
M
A
L
E
L
L
--
L
--
G
G
C
T
V
T
V
T
H
R
F
T
R
--
D
L
A
D
H
V
S
R
A
D
L
V
V
V
A
A
G
K
P
G
L
V
K
G
E
W
I
K
E
G
A
I
V
I
D
V
G
I
------
N
R
Q
-----
A
D
G
------
R
L
V
G
D
V
E
Y
E
V
A
A
Q
R
A
S
W
I
T
P
V
P
G
G
V
G
P
M
T
R
A
C
L
L
E
N
T
L
H
A
A
E
--------
7
PsiBlast_PDB
81.90
48%
-15
- C4 -
4B4W
4
?
A:
[23-302]
--
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
K
--
T
--
G
R
-
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
-
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
A
--
Q
-
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
A
M
G
-
E
--
A
--
A
-
Y
G
-
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
---
K
H
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
--
Q
--
A
N
A
T
V
T
I
C
H
S
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
P
R
-----
D
G
G
------
G
V
-
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
A
L
-----
5
PsiBlast_PDB
81.81
48%
-13
- C4 -
4B4U
9
?
A:
[23-302]
--
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
K
--
T
--
G
R
-
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
-
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
A
--
Q
-
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
A
M
G
-
E
--
A
--
A
-
Y
G
-
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
---
K
H
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
--
Q
--
A
N
A
T
V
T
I
C
H
S
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
P
R
-----
D
G
G
------
G
V
-
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
A
L
-----
50
HHSearch
81.63
47%
23
- C4 -
1A4I
1
C1TC_HUMAN
A:
[2-294]
A
P
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
-
E
Q
V
P
--
G
F
-
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
-
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
--
D
S
EN
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
A
R
G
-
D
LN
D
--
C
-
F
I
-
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
---
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
--
W
--
N
N
A
T
V
T
T
C
H
S
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y
---------------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
------
9
PsiBlast_PDB
81.56
46%
20
- C4 -
1DIB
2
C1TC_HUMAN
A:
[4-295]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
-
E
--
Q
VP
G
F
-
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
-
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
A
R
G
-
D
LN
D
--
C
-
F
I
-
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
---
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
--
W
--
N
N
A
T
V
T
T
C
H
S
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y
---------------
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
-----
28
PsiBlast_CBE
81.43
46%
23
- C4 -
1A4I
1
C1TC_HUMAN
B:
[4-295]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
-
E
--
Q
VP
G
F
-
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
-
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
A
R
G
-
D
LN
D
--
C
-
F
I
-
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
---
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
--
W
--
N
N
A
T
V
T
T
C
H
S
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y
V
PDDKK
P
N
G
R-----
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
-----
43
HHSearch
81.41
48%
-14
- C4 -
4B4U
9
?
A:
[22-301]
-
M
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
-
A
K
-
T
--
G
R
-
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
-
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
A
--
Q
-
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
A
M
G
-
E
--
A
--
A
-
Y
G
-
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
---
K
H
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
--
Q
--
A
N
A
T
V
T
I
C
H
S
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
P
R
-----
D
-
G
------
G
G
V
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
A
------
22
PsiBlast_CBE
81.35
48%
-9
- C4 -
4B4W
3
?
B:
[23-302]
--
A
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
K
--
T
--
G
R
-
T
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
-
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
A
--
Q
-
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
A
M
G
-
E
--
A
--
A
-
Y
G
-
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
---
K
H
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
--
Q
--
A
N
A
T
V
T
I
C
H
S
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
------
H
P
R
-----
D
G
G
------
G
V
-
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
A
L
-----
26
PsiBlast_CBE
80.97
46%
21
- C4 -
1DIB
1
C1TC_HUMAN
B:
[4-295]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
-
E
--
Q
VP
G
F
-
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
-
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
A
R
G
-
D
LN
D
--
C
-
F
I
-
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
---
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
--
W
--
N
N
A
T
V
T
T
C
H
S
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y
V
PDDKK
P
N
G
R-----
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
-----
30
PsiBlast_CBE
80.90
39%
-20
- C4 -
4CJX
2
?
B:
[25-316]
--
A
V
V
I
D
G
R
A
V
A
K
A
I
Q
K
E
L
T
E
E
V
A
L
L
E
-
R
--
R
YK
G
R
-
R
P
G
L
S
T
I
I
C
G
K
R
K
D
S
Q
T
Y
V
R
L
K
R
K
A
A
A
A
C
G
F
R
N
F
S
V
-
E
L
P
A
N
V
T
Q
E
A
L
E
R
E
V
I
R
L
N
E
E
E
A
C
H
S
I
V
V
Q
L
P
L
--
P
P
--
H
-
I
D
K
V
A
A
L
S
K
I
K
P
E
K
D
A
D
C
L
L
P
V
N
V
G
Q
L
H
I
R
-
E
--
R
NP
A
-
I
V
-
P
C
T
A
S
A
V
M
E
L
L
R
C
S
G
V
E
I
C
G
---
K
R
V
V
V
L
G
R
G
D
I
A
G
L
P
V
A
T
L
L
A
--
N
--
E
D
A
T
V
T
V
V
H
S
A
T
P
LC
D
I
A
D
I
V
R
A
S
D
I
V
V
S
A
A
G
Q
P
G
L
V
R
G
E
W
I
K
L
G
A
A
V
I
D
V
G
T
TPVADP
S
K
V
-----
P
G
Y
------
R
L
V
G
D
V
C
F
D
V
A
R
K
R
A
A
Y
I
T
P
V
P
G
G
V
G
P
V
T
V
S
M
L
L
K
N
T
L
T
M
F
K
R
S
V
-----
15
PsiBlast_PDB
80.21
39%
-15
- C4 -
4CJX
4
?
A:
[25-316]
--
A
V
V
I
D
G
R
A
V
A
K
A
I
Q
K
E
L
T
E
E
V
A
L
L
E
-
R
--
R
Y
K
G
R
-
R
P
G
L
S
T
I
I
C
G
K
R
K
D
S
Q
T
Y
V
R
L
K
R
K
A
A
A
A
C
G
F
R
N
F
S
V
-
E
L
P
A
N
V
T
Q
E
A
L
E
R
E
V
I
R
L
N
E
E
E
A
C
H
S
I
V
V
Q
L
P
L
--
P
P
--
H
-
I
D
K
V
A
A
L
S
K
I
K
P
E
K
D
A
D
C
L
L
P
V
N
V
G
Q
L
H
I
R
-
E
--
R
NP
A
-
I
V
-
P
C
T
A
S
A
V
M
E
L
L
R
C
S
G
V
E
I
C
G
---
K
R
V
V
V
L
G
R
G
D
I
A
G
L
P
V
A
T
L
L
A
--
N
--
E
D
A
T
V
T
V
V
H
S
A
T
P
L
C
D
I
A
D
I
V
R
A
S
D
I
V
V
S
A
A
G
Q
P
G
L
V
R
G
E
W
I
K
L
G
A
A
V
I
D
V
G
T
T
P
V
A
DP
S
K
V
-----
P
G
Y
------
R
L
V
G
D
V
C
F
D
V
A
R
K
R
A
A
Y
I
T
P
V
P
G
G
V
G
P
V
T
V
S
M
L
L
K
N
T
L
T
M
F
K
R
S
V
-----
27
PsiBlast_CBE
80.15
46%
21
- C4 -
1DIA
1
C1TC_HUMAN
B:
[4-295]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
-
E
--
Q
VP
G
F
-
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
-
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
A
R
G
-
D
LN
D
--
C
-
F
I
-
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
---
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
--
W
--
N
N
A
T
V
T
T
C
H
S
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y
V
PDDKK
P
N
G
R-----
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
-----
25
PsiBlast_CBE
80.06
46%
21
- C4 -
1DIG
2
C1TC_HUMAN
B:
[4-295]
--
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
-
E
--
Q
VP
G
F
-
T
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
-
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
A
R
G
-
D
LN
D
--
C
-
F
I
-
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
---
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
--
W
--
N
N
A
T
V
T
T
C
H
S
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
------
N
Y
V
PDDKK
P
N
G
R-----
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
-----
47
HHSearch
78.54
41%
6
- C4 -
4CJX
4
?
A:
[24-315]
-
E
A
V
V
I
D
G
R
A
V
A
K
A
I
Q
K
E
L
T
E
E
V
A
L
L
E
-
R
R
Y
K
--
G
R
-
R
P
G
L
S
T
I
I
C
G
K
R
K
D
S
Q
T
Y
V
R
L
K
R
K
A
A
A
A
C
G
F
-
R
N
F
S
V
E
L
P
A
N
V
T
Q
E
A
L
E
R
E
V
I
R
L
N
E
E
E
A
C
H
S
I
V
V
Q
L
P
L
--
P
P
--
H
-
I
D
K
V
A
A
L
S
K
I
K
P
E
K
D
A
D
C
L
L
P
V
N
V
G
Q
L
H
I
R
-
E
RN
P
--
A
-
I
V
-
P
C
T
A
S
A
V
M
E
L
L
R
C
S
G
V
E
I
C
G
---
K
R
V
V
V
L
G
R
G
D
I
A
G
L
P
V
A
T
L
L
A
--
N
--
E
D
A
T
V
T
V
V
H
S
A
T
P
L
C
D
I
A
D
I
V
R
A
S
D
I
V
V
S
A
A
G
Q
P
G
L
V
R
G
E
W
I
K
L
G
A
A
V
I
D
V
G
T
------
T
P
V
-----
A
D
P
SKVPG
Y
R
L
V
G
D
V
C
F
D
V
A
R
K
R
A
A
Y
I
T
P
V
P
G
G
V
G
P
V
T
V
S
M
L
L
K
N
T
L
T
M
F
K
R
S
------
16
PsiBlast_PDB
77.24
37%
-40
- C4 -
3NGL
1
FOLD_THEAC
A:
[3-270]
----
I
L
R
G
E
E
I
A
E
K
K
A
E
N
L
H
G
I
I
E
----
R
--
S
--
G
L
-
E
P
S
L
K
L
I
Q
I
G
D
N
E
A
A
S
I
Y
A
R
A
K
I
R
R
G
K
K
I
G
I
-
A
V
D
L
E
K
Y
D
D
-
I
S
M
K
D
L
L
K
R
I
D
D
L
A
K
D
P
Q
I
N
G
I
M
I
E
N
P
L
--
P
K
--
G
-
F
D
Y
Y
E
I
V
R
N
I
P
Y
Y
K
D
V
D
A
L
S
P
Y
N
Q
G
L
I
A
L
N
-
R
--
E
--
F
-
L
V
-
P
A
T
P
R
A
V
I
D
I
M
-----
D
Y
Y
G
YHE
N
T
V
T
I
V
N
R
S
P
V
V
G
R
P
L
S
M
M
L
L
--
N
--
R
N
Y
T
V
S
V
C
H
S
K
T
K
--
D
I
G
S
M
T
R
S
S
K
I
V
V
V
A
V
G
R
P
G
F
L
N
R
E
M
V
T
P
G
S
V
V
I
D
V
G
I
------
N
Y
V
------
N
D
------
K
V
V
G
D
A
N
F
E
D
L
S
E
Y
V
E
A
I
T
P
V
P
G
G
V
G
P
I
T
A
T
N
I
L
E
N
V
V
K
A
A
E
--------
31
PsiBlast_CBE
74.70
37%
-39
- C4 -
3NGL
1
FOLD_THEAC
C:
[3-270]
----
I
L
R
G
E
E
I
A
E
K
K
A
E
N
L
H
G
I
I
E
----
R
--
S
--
G
L
-
E
P
S
L
K
L
I
Q
I
G
D
N
E
A
A
S
I
Y
A
R
A
K
I
R
R
G
K
K
I
G
I
-
A
V
D
L
E
K
Y
D
D
-
I
S
M
K
D
L
L
K
R
I
D
D
L
A
K
D
P
Q
I
N
G
I
M
I
E
N
P
L
--
P
K
--
G
-
F
D
Y
Y
E
I
V
R
N
I
P
Y
Y
K
D
V
D
A
L
S
P
Y
N
Q
G
L
I
A
L
N
-
R
--
E
--
F
-
L
V
-
P
A
T
P
R
A
V
I
D
I
M
-----
D
Y
Y
G
YHE
N
T
V
T
I
V
N
R
S
P
V
V
G
R
P
L
S
M
M
L
L
--
N
--
R
N
Y
T
V
S
V
C
H
S
K
T
K
--
D
I
G
S
M
T
R
S
S
K
I
V
V
V
A
V
G
R
P
G
F
L
N
R
E
M
V
T
P
G
S
V
V
I
D
V
G
I
------
N
Y
V
------
N
D
------
K
V
V
G
D
A
N
F
E
D
L
S
E
Y
V
E
A
I
T
P
V
P
G
G
V
G
P
I
T
A
T
N
I
L
E
N
V
V
K
A
A
E
--------