@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu24850: (2016-07-09 )
MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITVTIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETETGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGGEIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSARDVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVEKTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC
Atome Classification :
(21 SA)
-----------------------------------------------------------------------.........10........20........30.....--.-..-40........50........60........70.....-----...80.......-.90.-.......100.......110.......120.......130.......140.......150.......160....--...170---------.......180........190.......200...-.-.--.-.-------210----.......220.......230.......240.......250.......260...-....270.......280...-....290........300.......310..-----.....320
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------MDE
I
W
F
A
G
IDLG
G
T
T
I
K
L
A
F
INQYGE
I
Q
H
K
WEVPTD--K-TG-
D
T
I
T
V
T
I
A
K
T
I
D
S
K
L
D
E
L
Q
K
P
K
H
I
I
K
Y
IGMGAPG
P
V
D
-----
M
A
A
G
V
V
Y
E
TVNL-GWKN-
Y
A
L
K
NHLETETGI
P
A
V
IENDA
N
I
A
A
L
G
E
M
W
KGAGDGA
K
D
V
I
L
V
T
LGTGVG
G
G
I
I
AN
G
E
I
V
H
GINGAGGEI
G
H
I
C--SIPEGG---------APCNCGK
T
G
-
C
I
E
T
I
A
SAT
G
I
V
R
I
A
K
E
K
IANAKK-T-
T
--
R
-L-------K
A
T
----
E
QL
S
A
R
D
V
F
E
AAGEN
D
E
I
A
L
E
V
V
D
Y
V
A
K
H
L
G
L
V
L
G
N
L
A
SSLNP
S
K
I
V
LGG
G
V
S
-
R
A
G
E
L
L
R
S
K
V
E
K
T
F
R
KCAFP-RAAQA-A
D
I
S
I
A
A
LGNDAGVIG
G
A
W
IAKNE-----WLKHQNC
34
HHSearch
78.84
46%
21
- C1 -
2QM1
5
?
A:
[4-322]
------------------------------------------------------------------------
M
D
K
K
I
I
G
I
D
L
G
G
T
T
I
K
F
A
I
L
T
T
D
G
V
V
Q
Q
K
W
S
I
E
T
N
--
I
L
E
D
G
K
H
I
V
P
S
I
I
E
S
I
R
H
R
I
D
L
Y
N
M
K
K
E
D
F
V
G
I
G
M
G
T
P
G
S
V
D
-----
I
E
K
G
T
V
V
G
A
Y
N
L
-
N
W
T
T
V
Q
P
V
K
E
Q
I
E
S
A
L
G
I
P
F
A
L
D
N
D
A
N
V
A
A
L
G
E
R
W
K
G
A
G
E
N
N
P
D
V
I
F
I
T
L
G
T
G
V
G
G
G
I
V
A
A
G
K
L
L
H
G
V
A
G
C
A
G
E
V
G
H
V
T
--
V
D
P
N
-
G
---------
F
D
C
T
C
G
K
R
G
-
C
L
E
T
V
S
S
A
T
G
V
V
R
V
A
R
H
L
S
E
E
F
A
G
D
S
-
E
L
K
Q
A
I
-------
D
D
G
----
Q
D
V
S
S
K
D
V
F
E
F
A
E
K
G
D
H
F
A
L
M
V
V
D
R
V
C
F
Y
L
G
L
A
T
G
N
L
G
N
T
L
N
P
D
S
V
V
I
G
G
G
V
S
-
A
A
G
E
F
L
R
S
R
V
E
K
Y
F
Q
E
F
T
F
P
-
Q
V
R
N
S
-
T
K
I
K
L
A
E
L
G
N
E
A
G
V
I
G
A
A
S
L
A
L
Q
F
------------
1
PsiBlast_PDB
74.69
46%
22
- C1 -
2QM1
5
?
A:
[10-319]
------------------------------------------------------------------------------
G
I
D
L
G
G
T
T
I
K
F
A
I
L
T
T
D
G
V
V
Q
Q
K
W
S
I
E
T
N
IL
E
-
D
G
-
K
H
I
V
P
S
I
I
E
S
I
R
H
R
I
D
L
Y
N
M
K
K
E
D
F
V
G
I
G
M
G
T
P
G
S
V
D
-----
I
E
K
G
T
V
V
G
A
Y
N
L
-
N
W
T
T
V
Q
P
V
K
E
Q
I
E
S
A
L
G
I
P
F
A
L
D
N
D
A
N
V
A
A
L
G
E
R
W
K
G
A
G
E
N
N
P
D
V
I
F
I
T
L
G
T
G
V
G
G
G
I
V
A
A
G
K
L
L
H
G
V
A
G
C
A
G
E
V
G
H
V
T
--
V
D
P
N
G
----------
F
D
C
T
C
G
K
R
G
-
C
L
E
T
V
S
S
A
T
G
V
V
R
V
A
R
H
L
S
E
E
F
A
G
-
D
-
S
--
E
-
L
-------
K
Q
A
I
D
D
G
Q
D
V
S
S
K
D
V
F
E
F
A
E
K
G
D
H
F
A
L
M
V
V
D
R
V
C
F
Y
L
G
L
A
T
G
N
L
G
N
T
L
N
P
D
S
V
V
I
G
G
G
V
S
-
A
A
G
E
F
L
R
S
R
V
E
K
Y
F
Q
E
F
T
F
P
-
Q
V
R
N
S
-
T
K
I
K
L
A
E
L
G
N
E
A
G
V
I
G
A
A
S
L
A
---------------
25
PsiBlast_CBE
74.47
35%
-48
- C1 -
3VGK
1
?
D:
[6-312]
------------------------------------------------------------------------------
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
K
V
A
T
P
--
P
-
T
A
-
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
E
-----
G
H
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
-----
D
K
R
A
T
V
L
F
A
P
N
I
-
D
W
R
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
--
V
V
P
D
G
----------
L
L
C
G
C
G
S
Q
G
-
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
-
A
N
A
T
P
-
E
-
N
--
A
-
A
VLLGLGD
G
S
V
----
D
G
I
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
-
D
E
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
-
G
E
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
L
A
R
Q
-------------
41
HHSearch
73.71
35%
-34
- C1 -
3VGL
4
?
A:
[2-313]
--------------------------------------------------------------------------
G
L
T
I
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
K
V
A
T
P
--
P
-
T
A
-
E
G
I
V
D
A
I
C
A
A
V
A
G
A
-----
S
E
G
H
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
-----
D
K
R
A
T
V
L
F
A
P
N
I
-
D
W
R
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
--
V
V
P
D
-
G
---------
L
L
C
G
C
G
S
Q
G
-
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
A
N
A
T
P
E
-
N
A
A
V
L
L
G
L
G
D-----
G
S
V
----
D
G
I
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
-
D
E
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
G
E
W
R
P
H
-
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
L
A
R
Q
G
------------
23
PsiBlast_CBE
73.49
35%
-47
- C1 -
3VGK
1
?
F:
[6-312]
------------------------------------------------------------------------------
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
K
V
A
T
P
--
P
-
T
A
-
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
E
-----
G
H
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
-----
D
K
R
A
T
V
L
F
A
P
N
I
-
D
W
R
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
--
V
V
P
D
G
----------
L
L
C
G
C
G
S
Q
G
-
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
-
A
N
A
T
P
-
E
-
N
--
A
-
A
VLLGLGD
G
S
V
----
D
G
I
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
-
D
E
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
-
G
E
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
L
A
R
Q
-------------
4
PsiBlast_PDB
73.18
35%
-43
- C1 -
3VGM
3
?
A:
[6-312]
------------------------------------------------------------------------------
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
K
V
A
T
P
--
P
-
T
A
-
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
E
-----
G
H
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
-----
D
K
R
A
T
V
L
F
A
P
N
I
-
D
W
R
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
--
V
V
P
D
G
----------
L
L
C
G
C
G
S
Q
G
-
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
-
A
N
A
T
P
-
E
-
N
--
A
-
A
V
L
L
G
L
G
D
G
S
V
----
D
G
I
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
-
D
E
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
-
G
E
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
L
A
R
Q
-------------
2
PsiBlast_PDB
72.75
35%
-48
- C1 -
3VGK
1
?
A:
[6-312]
------------------------------------------------------------------------------
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
K
V
A
T
P
--
P
-
T
A
-
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
E
-----
G
H
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
-----
D
K
R
A
T
V
L
F
A
P
N
I
-
D
W
R
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
--
V
V
P
D
G
----------
L
L
C
G
C
G
S
Q
G
-
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
-
A
N
A
T
P
-
E
-
N
--
A
-
A
V
L
L
G
L
G
D
G
S
V
----
D
G
I
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
-
D
E
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
-
G
E
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
L
A
R
Q
-------------
27
PsiBlast_CBE
72.54
35%
-52
- C1 -
3VGK
2
?
B:
[6-312]
------------------------------------------------------------------------------
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
K
V
A
T
P
--
P
-
T
A
-
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
E
-----
G
H
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
-----
D
K
R
A
T
V
L
F
A
P
N
I
-
D
W
R
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
--
V
V
P
D
G
----------
L
L
C
G
C
G
S
Q
G
-
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
-
A
N
A
T
P
-
E
-
N
--
A
-
A
V
L
L
G
L
G
D
G
S
V
----
D
G
I
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
-
D
E
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
-
G
E
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
L
A
R
Q
-------------
36
HHSearch
72.50
26%
-42
- C1 -
1Z05
7
?
A:
[106-415]
------------------------------------------------------------------------
L
G
W
Q
F
L
S
M
R
L
G
R
G
Y
L
T
I
A
L
H
E
L
G
G
E
V
L
I
D
T
K
I
D
I
H
--
E
-
I
D
Q
D
D
V
L
A
R
L
L
F
E
I
E
E
F
F
Q
T
Y
A
A
Q
L
D
R
V
T
S
I
A
I
T
L
P
G
L
V
N
-----
S
E
Q
G
I
V
L
Q
M
P
H
Y
-
N
V
K
N
-
L
A
L
G
P
E
I
Y
K
A
T
G
L
P
V
F
V
A
N
D
T
R
A
W
A
L
A
E
K
L
F
G
H
S
Q
D
V
D
N
S
V
L
I
S
I
H
H
G
L
G
A
G
I
V
L
D
G
R
V
L
Q
G
R
H
G
N
I
G
E
L
G
H
I
Q
--
I
D
P
Q
-
G
---------
K
R
C
H
C
G
N
Y
G
-
C
L
E
T
V
A
S
S
Q
A
I
R
D
Q
V
T
A
R
I
Q
A
G
E
P
-
S
-
C
----
L
-------
A
T
V
----
E
E
I
S
I
E
D
I
C
A
A
A
A
D
G
D
P
L
A
V
D
V
I
Q
Q
L
G
R
Y
L
G
A
A
I
A
I
V
I
N
L
F
N
P
E
K
I
L
I
G
G
V
I
N
-
Q
A
K
S
I
L
Y
P
S
I
E
Q
C
I
R
E
Q
S
L
P
-
V
Y
H
Q
D
-
L
K
L
V
E
S
R
F
Y
K
Q
A
T
M
P
G
A
A
L
I
K
Q
--------------
24
PsiBlast_CBE
72.35
35%
-48
- C1 -
3VGK
2
?
E:
[6-312]
------------------------------------------------------------------------------
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
K
V
A
T
P
--
P
-
T
A
-
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
E
-----
G
H
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
-----
D
K
R
A
T
V
L
F
A
P
N
I
-
D
W
R
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
--
V
V
P
D
G
----------
L
L
C
G
C
G
S
Q
G
-
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
-
A
N
A
T
P
-
E
-
N
--
A
-
A
VLLGLGD
G
S
V
----
D
G
I
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
-
D
E
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
-
G
E
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
L
A
R
Q
-------------
22
PsiBlast_CBE
72.29
35%
-48
- C1 -
3VGK
1
?
G:
[6-312]
------------------------------------------------------------------------------
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
K
V
A
T
P
--
P
-
T
A
-
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
E
-----
G
H
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
-----
D
K
R
A
T
V
L
F
A
P
N
I
-
D
W
R
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
--
V
V
P
D
G
----------
L
L
C
G
C
G
S
Q
G
-
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
-
A
N
A
T
P
-
E
-
N
--
A
-
A
VLLGLGD
G
S
V
----
D
G
I
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
-
D
E
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
-
G
E
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
L
A
R
Q
-------------
21
PsiBlast_CBE
71.60
35%
-42
- C1 -
3VGK
1
?
H:
[6-312]
------------------------------------------------------------------------------
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
K
V
A
T
P
--
P
-
T
A
-
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
E
-----
G
H
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
-----
D
K
R
A
T
V
L
F
A
P
N
I
-
D
W
R
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
--
V
V
P
D
G
----------
L
L
C
G
C
G
S
Q
G
-
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
-
A
N
A
T
P
-
E
-
N
--
A
-
A
VLLGLGD
G
S
V
----
D
G
I
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
-
D
E
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
-
G
E
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
L
A
R
Q
-------------
3
PsiBlast_PDB
70.94
35%
-35
- C1 -
3VGL
4
?
A:
[6-312]
------------------------------------------------------------------------------
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
K
V
A
T
P
--
P
-
T
A
-
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
E
-----
G
H
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
-----
D
K
R
A
T
V
L
F
A
P
N
I
-
D
W
R
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
--
V
V
P
D
G
----------
L
L
C
G
C
G
S
Q
G
-
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
-
A
N
A
T
P
-
E
-
N
--
A
-
A
V
L
L
G
L
G
D
G
S
V
----
D
G
I
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
-
D
E
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
-
G
E
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
L
A
R
Q
-------------
5
PsiBlast_PDB
70.27
29%
-119
- C1 -
1Z05
7
?
A:
[172-415]
---------------------------------------------------------------------------------------------------------------------------------------------
I
A
I
T
L
P
G
L
V
N
-----
S
E
Q
G
I
V
L
Q
M
P
H
Y
-
N
V
K
N
-
L
A
L
G
P
E
I
Y
K
A
T
G
L
P
V
F
V
A
N
D
T
R
A
W
A
L
A
E
K
L
F
G
H
S
Q
D
V
D
N
S
V
L
I
S
I
H
H
G
L
G
A
G
I
V
L
D
G
R
V
L
Q
G
R
H
G
N
I
G
E
L
G
H
I
Q
--
I
D
P
Q
G
K
---------
R
-
C
H
C
G
N
Y
G
-
C
L
E
T
V
A
S
S
Q
A
I
R
D
Q
V
T
A
R
I
-
Q
A
G
E
-
P
-
S
--
C
-
L
-------
A
T
V
----
E
E
I
S
I
E
D
I
C
A
A
A
A
D
G
D
P
L
A
V
D
V
I
Q
Q
L
G
R
Y
L
G
A
A
I
A
I
V
I
N
L
F
N
P
E
K
I
L
I
G
G
V
I
N
-
Q
A
K
S
I
L
Y
P
S
I
E
Q
C
I
R
E
Q
S
L
P
-
V
Y
H
Q
D
-
L
K
L
V
E
S
R
F
Y
K
Q
A
T
M
P
G
A
A
L
I
K
Q
--------------
26
PsiBlast_CBE
70.25
35%
-44
- C1 -
3VGK
1
?
C:
[6-312]
------------------------------------------------------------------------------
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
L
S
T
F
K
V
A
T
P
--
P
-
T
A
-
E
G
I
V
D
A
I
C
A
A
V
A
G
A
S
E
-----
G
H
D
V
E
A
V
G
I
G
A
A
G
Y
V
D
-----
D
K
R
A
T
V
L
F
A
P
N
I
-
D
W
R
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
--
V
V
P
D
G
----------
L
L
C
G
C
G
S
Q
G
-
C
W
E
Q
Y
A
S
G
R
A
L
V
R
Y
A
K
Q
R
-
A
N
A
T
P
-
E
-
N
--
A
-
A
VLLGLGD
G
S
V
----
D
G
I
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
-
D
E
G
E
L
V
L
D
P
I
R
K
S
F
R
R
W
L
I
G
-
G
E
W
R
P
H
A
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
L
A
R
Q
-------------
40
HHSearch
69.21
30%
-49
* C1 *
2AA4
1
NANK_ECOLI
A:
[1-289]
--------------------------------------------------------------------------
M
T
T
L
A
I
D
I
G
G
T
K
L
A
A
A
L
I
G
A
D
G
Q
I
R
D
R
R
E
L
P
T
P
--
A
-
S
---
Q
T
P
E
A
L
R
D
A
L
S
A
L
V
S
P
L
---
Q
A
H
A
Q
R
V
A
I
A
S
T
G
I
I
R
-----
D
G
S
L
L
A
L
N
P
H
N
L
G
G
L
L
H
-
F
P
L
V
K
T
L
E
Q
L
T
N
L
P
T
I
A
I
N
D
A
Q
A
A
A
W
A
E
F
Q
A
L
D
-
G
D
I
T
D
M
V
F
I
T
V
S
T
G
V
G
G
G
V
V
S
G
C
K
L
L
T
G
P
G
G
L
A
G
H
I
G
H
T
L
--
A
D
P
H
-
G
---------
P
V
C
G
C
G
R
T
G
-
C
V
E
A
I
A
S
G
R
G
I
A
A
A
A
Q
G
E
L
A
----------------------------
G
A
D
A
K
T
I
F
T
R
A
G
Q
G
D
E
Q
A
Q
Q
L
I
H
R
S
A
R
T
L
A
R
L
I
A
D
I
K
A
T
T
D
C
Q
C
V
V
V
G
G
S
V
G
-
L
A
-
E
G
Y
L
A
L
V
E
T
Y
L
A
Q
E
P
-
A
---
A
F
H
-
V
D
L
L
A
A
H
Y
R
H
D
A
G
L
L
G
A
A
L
L
A
Q
G
E
------------
59
Fugue
68.46
25%
2
- C1 -
1Z05
8
?
A:
[34-429]
D
H
I
K
Q
I
N
A
G
R
V
Y
K
L
I
D
Q
KGPIS
R
I
D
L
S
K
E
S
ELA
P
A
S
I
T
K
I
T
R
E
L
I
D
A
HLIHETT
V
Q
E
A
I
S
R
G
R
P
A
V
G
L
QTN
N
L
G
W
Q
F
L
S
M
R
L
G
R
G
Y
L
T
I
A
L
H
E
L
G
G
E
V
L
I
D
T
K
I
D
I
H
E-
I
-
D
Q
-
D
D
V
L
A
R
L
L
F
E
I
E
E
F
F
Q
T
Y
A
A
Q
L
D
R
V
T
S
I
A
I
T
L
P
G
L
V
N
-----
S
E
Q
G
I
V
L
Q
M
P
H
Y
-
N
V
K
N
-
L
A
L
G
P
E
I
Y
K
A
T
G
L
P
V
F
V
A
N
D
T
R
A
W
A
L
A
E
K
L
F
G
H
S
Q
D
V
D
N
S
V
L
I
S
I
H
H
G
L
G
A
G
I
V
L
D
G
R
V
L
Q
G
R
H
G
N
I
G
E
L
G
H
I
---
Q
I
D
P
Q
G
---------
K
R
C
H
C
G
N
Y
G
-
C
L
E
T
V
A
S
S
Q
A
I
R
D
Q
V
T
A
R
I
Q
A
-
G
E
-
P
-
S
--
C
-
L
-------
A
T
V
----
E
E
I
S
I
E
D
I
C
A
A
A
A
D
G
D
P
L
A
V
D
V
I
Q
Q
L
G
R
Y
L
G
A
A
I
A
I
V
I
N
L
F
N
P
E
K
I
L
I
G
G
V
I
N
-
Q
A
K
S
I
L
Y
P
S
I
E
Q
C
I
R
E
Q
S
L
P
-
V
Y
H
Q
D
-
L
K
L
V
E
S
R
F
Y
K
Q
A
T
M
P
G
A
A
L
I
K
Q
A
L
Y
D
G
L
L
L
M
K
V
V
E
G
35
HHSearch
67.55
26%
-19
- C1 -
1Z6R
1
MLC_ECOLI
A:
[83-397]
------------------------------------------------------------------------
E
A
W
H
Y
L
S
L
R
I
S
R
G
E
I
F
L
A
L
R
D
L
S
S
K
L
V
V
E
E
S
Q
E
L
A
--
L
-
K
D
D
L
P
L
L
D
R
I
I
S
H
I
D
Q
F
F
I
R
H
Q
K
K
L
E
R
L
T
S
I
A
I
T
L
P
G
I
I
D
-----
T
E
N
G
I
V
H
R
M
P
F
Y
E
D
V
K
E
-
M
P
L
G
E
A
L
E
Q
H
T
G
V
P
V
Y
I
Q
H
D
I
S
A
W
T
M
A
E
A
L
F
G
A
S
R
G
A
R
D
V
I
Q
V
V
I
D
H
N
V
G
A
G
V
I
T
D
G
H
L
L
H
A
G
S
S
S
L
V
E
I
G
H
T
Q
--
V
D
P
Y
-
G
---------
K
R
C
Y
C
G
N
H
G
-
C
L
E
T
I
A
S
V
D
S
I
L
E
L
A
Q
L
R
L
N
Q
S
M
S
-
S
-
M
----
L
--------
H
G
----
Q
P
L
T
V
D
S
L
C
Q
A
A
L
R
G
D
L
L
A
K
D
I
I
T
G
V
G
A
H
V
G
R
I
L
A
I
M
V
N
L
F
N
P
Q
K
I
L
I
G
S
P
L
S
-
K
A
A
D
I
L
F
P
V
I
S
D
S
I
R
Q
Q
A
L
P
-
A
Y
S
Q
H
-
I
S
V
E
S
T
Q
F
S
N
Q
G
T
M
A
G
A
A
-
L
V
K
D
A
-----
M
Y
N
G
---
44
HHSearch
65.90
30%
-31
- C1 -
4DB3
5
NAGK_VIBVU
A:
[24-326]
--------------------------------------------------------------------------
A
M
Y
Y
G
F
D
V
G
G
T
K
I
E
F
G
A
F
N
E
K
L
E
R
V
A
T
E
R
V
P
T
P
--
T
-
D
D
----
Y
P
L
L
L
E
T
I
A
G
L
V
A
K
Y
D
Q
E
F
A
C
E
G
K
I
G
L
G
L
P
G
M
E
D
-----
A
D
D
A
T
V
L
T
V
N
V
P
-
A
A
K
G
-
K
P
L
R
A
D
L
E
A
K
I
G
R
S
V
K
I
E
N
D
A
N
C
F
A
L
S
E
A
W
D
E
E
L
Q
D
A
P
S
V
M
G
L
I
L
G
T
G
F
G
G
G
L
I
Y
E
G
K
V
F
S
G
R
N
N
V
A
G
E
L
G
H
M
R
--
L
P
L
D
A
W
F
H
L
GDNAPL
L
G
C
G
C
G
K
K
G
-
C
L
D
S
Y
L
S
G
R
G
F
E
L
L
Y
A
H
Y
Y
G
E
---------------------------
E
K
K
A
I
D
I
I
K
A
N
A
A
G
D
E
K
A
A
E
H
V
E
R
F
M
E
L
L
A
I
C
F
G
N
I
F
T
A
N
D
P
H
V
V
A
L
G
G
G
L
S
-
N
F
-
E
L
I
Y
E
E
M
P
K
R
V
P
K
Y
L
L
S
-
V
-
A
K
C
-
P
K
I
I
K
A
K
H
G
D
S
G
G
V
R
G
A
A
F
L
N
I
K
-------------
29
PsiBlast_CBE
65.81
31%
-73
- C1 -
3VOV
3
?
C:
[5-296]
------------------------------------------------------------------------------
G
L
D
L
G
G
T
K
I
A
A
G
V
F
D
G
K
-
R
L
L
S
K
V
V
V
P
T
P
--
K
-
E
G
-
G
E
R
V
A
E
A
L
A
E
A
A
E
R
A
E
R
E
A
G
V
R
G
--
E
A
I
G
L
G
T
P
G
P
L
D
-----
F
R
R
G
V
I
---------
Q
D
-
F
P
I
R
R
I
L
E
E
A
T
G
R
P
V
F
L
E
N
D
A
N
A
A
A
L
A
E
H
H
L
G
A
A
Q
G
E
E
S
S
L
Y
L
T
V
S
T
G
I
G
G
G
V
V
L
G
G
R
V
L
R
G
E
R
G
Q
G
G
E
L
G
H
L
T
--
L
L
P
-
G
G
---------
P
A
C
G
C
G
L
E
G
-
C
L
E
A
L
A
A
G
R
A
L
E
R
D
A
T
Y
A
F
Q
R
P
V
D
-
T
--------------------------
R
E
L
F
R
L
F
Q
A
G
D
P
K
A
E
R
L
V
L
Q
A
A
R
Y
V
G
I
G
L
A
S
L
V
K
A
F
D
P
G
V
V
V
L
G
G
G
V
A
L
N
A
P
E
G
Y
W
E
A
L
L
E
A
Y
R
R
--
Y
L
-
Q
G
W
E
A
-
P
P
L
R
R
A
R
L
G
A
E
A
G
L
L
G
A
A
L
T
A
Y
L
E
------------
16
PsiBlast_PDB
30.87
31%
-13
- C1 -
3LM9
4
SCRK_BACSU
A:
[7-183]
------------------------------------------------------------------------------
G
I
E
A
G
G
T
K
F
V
C
A
V
G
R
E
D
G
T
I
I
D
R
I
E
F
P
T
K
--
M
-
P
D
-
E
T
I
E
K
V
I
Q
Y
F
S
Q
F
S
L
----------
Q
A
I
G
I
G
S
F
G
P
V
D
NDKTS
Q
T
Y
G
T
I
T
A
T
P
K
A
-
G
W
R
H
-
Y
P
F
L
Q
T
V
K
N
E
M
K
I
P
V
G
F
S
T
D
V
N
A
A
A
L
G
E
F
L
F
G
E
A
K
G
L
D
S
C
L
Y
I
T
I
G
T
G
I
G
A
G
A
I
V
E
G
R
L
L
Q
G
L
S
H
P
--
E
M
G
H
I
Y
IR
R
H
P
D
D
V
---------
Y
Q
G
K
C
P
Y
H
G
D
C
F
E
G
L
A
S
G
P
A
I
---------------------------------------------------------------------------------------------------------------------------------------------------------