@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu24950: (2016-07-09 )
MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAIIGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQKGNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGGQQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQAARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG
Atome Classification :
(47 SA)
.........10........20...----....--.30--.........40........50........60....-....70.........80.-----------..-----------------.....90----.----..----.....100.----.--...-.-.110......----.120.-.-.....130......----...140-----..---..--...150----....-...160.......170.-......180.......190...--....200--.-.--.-....210.......220.......230........240.....-..250.......260-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
I
A
T
E
A
V
M
K
Q
E
V
Y
Q
VN
G
M
N
LWYG----QHHA--LK---NI
N
L
S
I
Y
EN
E
V
T
A
I
IGPSGCG
K
S
T
F
I
K
T
L
N
L
M
I
Q
M-TPN
V
K
-
L
A
G
E
LNYNGSNI-----------LK-----------------DK
V
D
I
V
D
----
L
----
R
K
----NIG
M
V
FQKG----N--PF
P
-
Q
-
S
I
F
DNVAYGP----RVHGT-
K
-
N
K
K
K
L
Q
--
E
I
V
E
K
S
----
L
K
D
V
A
L
-----
W
D
---
E
V
--
K
D
R
L
H
T
----
S
ALS-LSGG
Q
Q
Q
R
L
C
I
A
R
A
LAT-NP
D
I
L
L
MDEPTSALDPI
S
T
R
K
I
--
E
E
L
I
L
E
L--K-D--
K
-
Y
T
I
V
I
V
TH
N
M
Q
Q
A
ARVSDQ
T
A
F
F
Y
M
-
G
E
L
VECDNTNKMFSNPK-DQ
R
T
L
D
Y
ISGKFG---
132
HHSearch
86.32
35%
0
- C- -
4FWI
3
?
B:
[3-266]
-----------
I
I
I
R
V
E
D
L
R
A
V
Y
L
VREG
T
I
K
A
--
A
D
---
G
I
S
L
D
I
L
E
N
S
V
T
A
I
V
G
E
S
A
S
G
K
S
T
I
I
E
A
M
T
K
T
L
P
P
-
N
G
-
R
I
-
L
S
G
R
V
L
Y
K
G
K
D
L
-----------
L
T
-------------------
M
R
E
E
E
LRKI
R
----
W
K
----
E
I
A
L
V
P
Q
A
A
----
Q
QS
L
N
P
T
M
-
K
V
I
E
H
F
K
D
T
V
----
E
A
H
G
V
-
R
W
S
H
S
E
L
I
--
E
K
A
S
E
K
----
L
R
M
V
R
L
-----
N
P
-------
E
A
V
L
N
S
----
Y
P
L
Q
-
L
S
G
G
M
K
Q
R
V
L
I
A
L
A
L
L
L
-
D
P
V
V
L
I
L
D
E
P
T
S
A
L
D
V
L
T
Q
A
H
I
--
I
Q
L
L
K
E
L
--
K
-
K
ML
K
-
I
T
L
I
F
V
T
H
D
I
A
V
A
A
E
L
A
D
K
V
A
V
I
Y
G
-
G
N
L
V
E
Y
N
S
T
F
Q
I
F
K
N
P
L
-
H
P
Y
T
R
G
L
I
N
-------
2
PsiBlast_PDB
81.71
36%
-22
- C1 -
4U02
1
?
A:
[2-238]
----------
E
P
I
I
R
I
R
N
L
H
K
W
F
G
----
P
L
H
V
--
L
K
---
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
-
Q
------
E
G
E
V
V
V
D
G
L
S
V
------------
K
-----------------
D
D
R
A
L
R
E
----
I
----
R
R
----
E
V
G
M
V
F
Q
Q
F
----
N
--
L
F
P
-
H
M
T
V
L
E
N
V
T
L
A
P
MRVR
R
W
P
R
E
-
K
-
A
E
K
K
A
L
--
E
L
L
E
R
--------
V
G
I
-----
L
D
---
Q
A
--
R
----
K
----
Y
P
A
Q
-
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
--
L
D
V
M
R
D
L
A
-
Q
-
G
--
G
-
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
-
E
E
R
T
R
S
F
L
--------
23
PsiBlast_CBE
81.31
36%
-19
- C1 -
4U02
1
?
B:
[2-238]
----------
E
P
I
I
R
I
R
N
L
H
K
W
F
G
----
P
L
H
V
--
L
K
---
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
-
Q
------
E
G
E
V
V
V
D
G
L
S
V
------------
K
-----------------
D
D
R
A
L
R
E
----
I
----
R
R
----
E
V
G
M
V
F
Q
Q
F
----
N
--
L
F
P
-
H
M
T
V
L
E
N
V
T
L
A
P
MRVR
R
W
P
R
E
-
K
-
A
E
K
K
A
L
--
E
L
L
E
R
--------
V
G
I
-----
L
D
---
Q
A
--
R
----
K
----
Y
P
A
Q
-
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
--
L
D
V
M
R
D
L
A-
Q
-
G
--
G
-
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
-
E
E
R
T
R
S
F
L
--------
21
PsiBlast_CBE
81.31
36%
-17
- C1 -
4U02
1
?
D:
[2-238]
----------
E
P
I
I
R
I
R
N
L
H
K
W
F
G
----
P
L
H
V
--
L
K
---
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
-
Q
------
E
G
E
V
V
V
D
G
L
S
V
------------
K
-----------------
D
D
R
A
L
R
E
----
I
----
R
R
----
E
V
G
M
V
F
Q
Q
F
----
N
--
L
F
P
-
H
M
T
V
L
E
N
V
T
L
A
P
MRVR
R
W
P
R
E
-
K
-
A
E
K
K
A
L
--
E
L
L
E
R
--------
V
G
I
-----
L
D
---
Q
A
--
R
----
K
----
Y
P
A
Q
-
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
--
L
D
V
M
R
D
L
A-
Q
-
G
--
G
-
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
-
E
E
R
T
R
S
F
L
--------
22
PsiBlast_CBE
80.57
36%
-21
- C1 -
4U02
1
?
C:
[2-238]
----------
E
P
I
I
R
I
R
N
L
H
K
W
F
G
----
P
L
H
V
--
L
K
---
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
-
Q
------
E
G
E
V
V
V
D
G
L
S
V
------------
K
-----------------
D
D
R
A
L
R
E
----
I
----
R
R
----
E
V
G
M
V
F
Q
Q
F
----
N
--
L
F
P
-
H
M
T
V
L
E
N
V
T
L
A
P
MRVR
R
W
P
R
E
-
K
-
A
E
K
K
A
L
--
E
L
L
E
R
--------
V
G
I
-----
L
D
---
Q
A
--
R
----
K
----
Y
P
A
Q
-
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
--
L
D
V
M
R
D
L
A-
Q
-
G
--
G
-
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
-
E
E
R
T
R
S
F
L
--------
4
PsiBlast_PDB
80.47
38%
-54
- C1 -
4YMT
-
?
J:
[4-237]
---------------
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
--
L
K
---
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
-
T
------
K
G
E
V
F
I
D
G
V
K
I
-----------
N
N
-----------------
G
K
V
N
I
N
K
----
V
----
R
Q
----
K
V
G
M
V
F
Q
H
F
----
N
--
L
F
P
-
H
L
T
A
I
E
N
I
T
L
A
P
----
V
K
V
K
K
-
M
-
N
K
K
E
A
E
--
E
L
A
V
D
L
----
L
A
K
V
G
L
-----
L
D
---
K
---
K
D
Q
Y
-------
P
I
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
--
L
N
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
-
N
E
R
T
R
E
F
L
S
-------
1
PsiBlast_PDB
80.39
36%
-16
* C1 *
4U00
3
?
A:
[3-238]
-----------
P
I
I
R
I
R
N
L
H
K
W
F
G
----
P
L
H
V
--
L
K
---
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
-
Q
------
E
G
E
V
V
V
D
G
L
S
V
------------
K
-----------------
D
D
R
A
L
R
E
----
I
----
R
R
----
E
V
G
M
V
F
Q
Q
F
----
N
--
L
F
P
-
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
P
R
E
-
K
-
A
E
K
K
A
L
--
E
L
L
E
R
--------
V
G
I
-----
L
D
---
Q
A
--
R
----
K
----
Y
P
A
Q
-
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
--
L
D
V
M
R
D
L
A
-
Q
-
G
--
G
-
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
-
E
E
R
T
R
S
F
L
--------
10
PsiBlast_PDB
79.93
38%
-32
- C1 -
2OUK
1
?
A:
[34-263]
----------------------
F
G
----
S
L
E
V
--
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
------
E
G
E
I
I
I
D
G
I
N
L
-----------
K
A
-----------------
K
D
T
N
L
N
K
----
V
----
R
E
----
E
V
G
M
V
F
Q
R
F
----
N
--
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
--------
M
-
K
-
V
R
K
W
P
R
--
E
K
A
E
A
------
K
A
M
E
L
-----
L
D
---
K
V
GL
K
D
K
A
H
A
----
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
--
L
S
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
7
PsiBlast_PDB
79.75
38%
-55
- C1 -
4YMW
-
?
J:
[4-237]
---------------
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
--
L
K
---
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
-
T
------
K
G
E
V
F
I
D
G
V
K
I
-----------
N
N
-----------------
G
K
V
N
I
N
K
----
V
----
R
Q
----
K
V
G
M
V
F
Q
H
F
----
N
--
L
F
P
-
H
L
T
A
I
E
N
I
T
L
A
P
----
V
K
V
K
K
-
M
-
N
K
K
E
A
E
--
E
L
A
V
D
L
----
L
A
K
V
G
L
-----
L
D
---
K
---
K
D
Q
Y
-------
P
I
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
--
L
N
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
-
N
E
R
T
R
E
F
L
S
-------
34
PsiBlast_CBE
79.53
38%
-27
- C1 -
2OLJ
3
?
B:
[34-263]
----------------------
F
G
----
S
L
E
V
--
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
------
E
G
E
I
I
I
D
G
I
N
L
-----------
K
A
-----------------
K
D
T
N
L
N
K
----
V
----
R
E
----
E
V
G
M
V
F
Q
R
F
----
N
--
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
--------
M
-
K
-
V
R
K
W
P
R
--
E
K
A
E
A
------
K
A
M
E
L
-----
L
D
---
K
V
GL
K
D
K
A
H
A
----
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
--
L
S
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
6
PsiBlast_PDB
78.83
38%
-54
- C1 -
4YMV
1
?
J:
[4-237]
---------------
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
--
L
K
---
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
-
T
------
K
G
E
V
F
I
D
G
V
K
I
-----------
N
N
-----------------
G
K
V
N
I
N
K
----
V
----
R
Q
----
K
V
G
M
V
F
Q
H
F
----
N
--
L
F
P
-
H
L
T
A
I
E
N
I
T
L
A
P
----
V
K
V
K
K
-
M
-
N
K
K
E
A
E
--
E
L
A
V
D
L
----
L
A
K
V
G
L
-----
L
D
---
K
---
K
D
Q
Y
-------
P
I
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
--
L
N
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
-
N
E
R
T
R
E
F
L
S
-------
29
PsiBlast_CBE
78.32
38%
-36
- C1 -
2OUK
1
?
C:
[34-263]
----------------------
F
G
----
S
L
E
V
--
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
------
E
G
E
I
I
I
D
G
I
N
L
-----------
K
A
-----------------
K
D
T
N
L
N
K
----
V
----
R
E
----
E
V
G
M
V
F
Q
R
F
----
N
--
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
--------
M
-
K
-
V
R
K
W
P
R
--
E
K
A
E
A
------
K
A
M
E
L
-----
L
D
---
K
V
GL
K
D
K
A
H
A
----
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
--
L
S
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
25
PsiBlast_CBE
77.99
38%
-54
- C1 -
4YMU
2
?
A:
[4-237]
---------------
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
--
L
K
---
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
-
T
------
K
G
E
V
F
I
D
G
V
K
I
-----------
N
N
-----------------
G
K
V
N
I
N
K
----
V
----
R
Q
----
K
V
G
M
V
F
Q
H
F
----
N
--
L
F
P
-
H
L
T
A
I
E
N
I
T
L
A
P
----
V
K
V
K
K
-
M
-
N
K
K
E
A
E
--
E
L
A
V
D
L
----
L
A
K
V
G
L
-----
L
D
---
K
---
K
D
Q
Y
-------
P
I
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
--
L
N
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
-
N
E
R
T
R
E
F
L
S
-------
26
PsiBlast_CBE
77.93
38%
-26
- C1 -
3C4J
4
?
B:
[34-263]
----------------------
F
G
----
S
L
E
V
--
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
------
E
G
E
I
I
I
D
G
I
N
L
-----------
K
A
-----------------
K
D
T
N
L
N
K
----
V
----
R
E
----
E
V
G
M
V
F
Q
R
F
----
N
--
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
--------
M
-
K
-
V
R
K
W
P
R
--
E
K
A
E
A
------
K
A
M
E
L
-----
L
D
---
K
V
GL
K
D
K
A
H
A
----
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
--
L
S
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
5
PsiBlast_PDB
77.87
38%
-55
- C1 -
4YMU
2
?
J:
[4-237]
---------------
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
--
L
K
---
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
-
T
------
K
G
E
V
F
I
D
G
V
K
I
-----------
N
N
-----------------
G
K
V
N
I
N
K
----
V
----
R
Q
----
K
V
G
M
V
F
Q
H
F
----
N
--
L
F
P
-
H
L
T
A
I
E
N
I
T
L
A
P
----
V
K
V
K
K
-
M
-
N
K
K
E
A
E
--
E
L
A
V
D
L
----
L
A
K
V
G
L
-----
L
D
---
K
---
K
D
Q
Y
-------
P
I
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
--
L
N
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
-
N
E
R
T
R
E
F
L
S
-------
3
PsiBlast_PDB
77.87
38%
-54
- C1 -
4YMS
-
?
J:
[4-237]
---------------
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
--
L
K
---
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
-
T
------
K
G
E
V
F
I
D
G
V
K
I
-----------
N
N
-----------------
G
K
V
N
I
N
K
----
V
----
R
Q
----
K
V
G
M
V
F
Q
H
F
----
N
--
L
F
P
-
H
L
T
A
I
E
N
I
T
L
A
P
----
V
K
V
K
K
-
M
-
N
K
K
E
A
E
--
E
L
A
V
D
L
----
L
A
K
V
G
L
-----
L
D
---
K
---
K
D
Q
Y
-------
P
I
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
--
L
N
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
-
N
E
R
T
R
E
F
L
S
-------
8
PsiBlast_PDB
77.72
38%
-35
- C1 -
2OLJ
4
?
A:
[34-263]
----------------------
F
G
----
S
L
E
V
--
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
------
E
G
E
I
I
I
D
G
I
N
L
-----------
K
A
-----------------
K
D
T
N
L
N
K
----
V
----
R
E
----
E
V
G
M
V
F
Q
R
F
----
N
--
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
--------
M
-
K
-
V
R
K
W
P
R
--
E
K
A
E
A
------
K
A
M
E
L
-----
L
D
---
K
V
GL
K
D
K
A
H
A
----
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
--
L
S
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
31
PsiBlast_CBE
77.03
38%
-34
- C1 -
2OLK
1
?
D:
[34-263]
----------------------
F
G
----
S
L
E
V
--
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
------
E
G
E
I
I
I
D
G
I
N
L
-----------
K
A
-----------------
K
D
T
N
L
N
K
----
V
----
R
E
----
E
V
G
M
V
F
Q
R
F
----
N
--
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
--------
M
-
K
-
V
R
K
W
P
R
--
E
K
A
E
A
------
K
A
M
E
L
-----
L
D
---
K
V
GL
K
D
K
A
H
A
----
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
--
L
S
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
9
PsiBlast_PDB
76.95
38%
-35
- C1 -
2OLK
1
?
A:
[34-263]
----------------------
F
G
----
S
L
E
V
--
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
------
E
G
E
I
I
I
D
G
I
N
L
-----------
K
A
-----------------
K
D
T
N
L
N
K
----
V
----
R
E
----
E
V
G
M
V
F
Q
R
F
----
N
--
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
--------
M
-
K
-
V
R
K
W
P
R
--
E
K
A
E
A
------
K
A
M
E
L
-----
L
D
---
K
V
GL
K
D
K
A
H
A
----
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
--
L
S
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
13
PsiBlast_PDB
76.77
38%
-32
- C1 -
3C41
3
?
J:
[13-242]
----------------------
F
G
----
S
L
E
V
--
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
------
E
G
E
I
I
I
D
G
I
N
L
-----------
K
A
-----------------
K
D
T
N
L
N
K
----
V
----
R
E
----
E
V
G
M
V
F
Q
R
F
----
N
--
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
--------
M
-
K
-
V
R
K
W
P
R
--
E
K
A
E
A
------
K
A
M
E
L
-----
L
D
---
K
V
GL
K
D
K
A
H
A
----
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
--
L
S
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
11
PsiBlast_PDB
76.25
38%
-34
- C1 -
2Q0H
4
?
A:
[34-263]
----------------------
F
G
----
S
L
E
V
--
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
------
E
G
E
I
I
I
D
G
I
N
L
-----------
K
A
-----------------
K
D
T
N
L
N
K
----
V
----
R
E
----
E
V
G
M
V
F
Q
R
F
----
N
--
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
--------
M
-
K
-
V
R
K
W
P
R
--
E
K
A
E
A
------
K
A
M
E
L
-----
L
D
---
K
V
GL
K
D
K
A
H
A
----
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
--
L
S
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
35
PsiBlast_CBE
76.10
38%
-29
- C1 -
3C41
3
?
K:
[13-242]
----------------------
F
G
----
S
L
E
V
--
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
------
E
G
E
I
I
I
D
G
I
N
L
-----------
K
A
-----------------
K
D
T
N
L
N
K
----
V
----
R
E
----
E
V
G
M
V
F
Q
R
F
----
N
--
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
--------
M
-
K
-
V
R
K
W
P
R
--
E
K
A
E
A
------
K
A
M
E
L
-----
L
D
---
K
V
GL
K
D
K
A
H
A
----
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
--
L
S
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
12
PsiBlast_PDB
75.90
38%
-34
- C1 -
3C4J
3
?
A:
[34-263]
----------------------
F
G
----
S
L
E
V
--
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
------
E
G
E
I
I
I
D
G
I
N
L
-----------
K
A
-----------------
K
D
T
N
L
N
K
----
V
----
R
E
----
E
V
G
M
V
F
Q
R
F
----
N
--
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
--------
M
-
K
-
V
R
K
W
P
R
--
E
K
A
E
A
------
K
A
M
E
L
-----
L
D
---
K
V
GL
K
D
K
A
H
A
----
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
--
L
S
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
33
PsiBlast_CBE
75.86
38%
-35
- C1 -
2OLK
2
?
B:
[34-263]
----------------------
F
G
----
S
L
E
V
--
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
------
E
G
E
I
I
I
D
G
I
N
L
-----------
K
A
-----------------
K
D
T
N
L
N
K
----
V
----
R
E
----
E
V
G
M
V
F
Q
R
F
----
N
--
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
--------
M
-
K
-
V
R
K
W
P
R
--
E
K
A
E
A
------
K
A
M
E
L
-----
L
D
---
K
V
GL
K
D
K
A
H
A
----
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
--
L
S
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
32
PsiBlast_CBE
75.53
38%
-34
- C1 -
2OLK
1
?
C:
[34-263]
----------------------
F
G
----
S
L
E
V
--
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
------
E
G
E
I
I
I
D
G
I
N
L
-----------
K
A
-----------------
K
D
T
N
L
N
K
----
V
----
R
E
----
E
V
G
M
V
F
Q
R
F
----
N
--
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
--------
M
-
K
-
V
R
K
W
P
R
--
E
K
A
E
A
------
K
A
M
E
L
-----
L
D
---
K
V
GL
K
D
K
A
H
A
----
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
--
L
S
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
24
PsiBlast_CBE
75.44
38%
-53
- C1 -
4YMV
1
?
A:
[4-237]
---------------
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
--
L
K
---
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
-
T
------
K
G
E
V
F
I
D
G
V
K
I
-----------
N
N
-----------------
G
K
V
N
I
N
K
----
V
----
R
Q
----
K
V
G
M
V
F
Q
H
F
----
N
--
L
F
P
-
H
L
T
A
I
E
N
I
T
L
A
P
----
V
K
V
K
K
-
M
-
N
K
K
E
A
E
--
E
L
A
V
D
L
----
L
A
K
V
G
L
-----
L
D
---
K
---
K
D
Q
Y
-------
P
I
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
--
L
N
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
-
N
E
R
T
R
E
F
L
S
-------
44
PsiBlast_CBE
73.60
33%
-2
- C1 -
1B0U
4
HISP_SALTY
A:
[5-257]
-----------
N
K
L
H
V
I
D
L
H
K
R
Y
G
----
G
H
E
V
--
L
K
---
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
-
S
------
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
KDGQLK
V
A
-----------------
D
K
N
Q
L
R
L
----
L
----
R
T
----
R
L
T
M
V
F
Q
H
F
----
N
--
L
W
S
-
H
M
T
V
L
E
N
V
M
E
A
P
I---
Q
V
L
G
L
---
S
K
H
D
A
R
--
E
R
A
L
K
Y
----
L
A
K
V
G
I
-----
D
E
---
R
A
--
Q
G
K
Y
-------
P
V
H
-
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
-
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
--
L
R
I
M
Q
Q
L
--
A
-
E
--
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
-
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
-
S
P
R
L
Q
Q
F
L
K
G
S
L
----
27
PsiBlast_CBE
69.96
38%
-36
- C1 -
2Q0H
4
?
B:
[34-263]
----------------------
F
G
----
S
L
E
V
--
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-
D
------
E
G
E
I
I
I
D
G
I
N
L
-----------
K
A
-----------------
K
D
T
N
L
N
K
----
V
----
R
E
----
E
V
G
M
V
F
Q
R
F
----
N
--
L
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
--------
M
-
K
-
V
R
K
W
P
R
--
E
K
A
E
A
------
K
A
M
E
L
-----
L
D
---
K
V
GL
K
D
K
A
H
A
----
Y
P
D
S
-
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
--
L
S
V
M
K
Q
L
--
A
-
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
-
H
E
R
T
K
A
F
L
S
K
V
F
----
106
Fugue
65.77
33%
23
- C1 -
1B0U
4
HISP_SALTY
A:
[5-261]
-----------
N
K
L
H
V
I
D
L
H
K
R
Y
G
----
G
-----
H
E
VLK
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
-
S
------
E
G
A
I
I
V
N
G
---------------
Q
NI
N
L
V
R
D
KDGQLKVAD
K
N
Q
L
R
L
L
R
----
T
-----
R
-----
L
T
M
V
F
Q
H
F
----
N
--
L
W
S
-
H
M
T
V
L
E
N
V
M
E
A
P
----
I
Q
V
L
-G
L
-
S
K
H
D
A
R
--
E
R
A
L
K
Y
----
L
A
K
V
G
I
-----
D
E
---
R
A
--
Q
G
---
K
----
Y
P
V
H
-
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E-
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
--
L
R
I
M
Q
Q
L
--
A
-
E
--
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
-Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
-Q
S
P
R
L
Q
Q
F
L
K
G
S
L
K
KLE
51
PsiBlast_CBE
57.33
32%
-38
- C1 -
4AYW
1
ABCBA_HUMAN
A:
[391-598]
----------------------------------
F
Q
---
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
---
V
L
S
L
L
L
R
L
-
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
------------------------------
R
Q
L
N
P
V
W
----
L
----
R
S
----
K
I
G
T
V
S
Q
E
P
----
I
--
L
F
S
-
C
-
S
I
A
E
N
I
A
Y
G
A
----
D
D
P
S
S
-
V
-
T
A
E
E
I
Q
--
R
V
A
E
V
A
-----
N
A
V
A
F
-----
I
R
---
N
F
--
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
-
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
-
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
--
Q
E
A
L
D
R
L
--
M
-
D
--
G
-
R
T
V
L
V
I
A
H
H
L
-
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
-
G
K
I
T
E
Y
G
K
H
E
E
-----------------------
52
PsiBlast_CBE
57.13
32%
-39
- C1 -
4AYX
2
ABCBA_HUMAN
A:
[360-572]
----------------------------------
F
Q
---
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
---
V
L
S
L
L
L
R
L
-
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
------------------------------
R
Q
L
N
P
V
W
----
L
----
R
S
----
K
I
G
T
V
S
Q
E
P
----
I
--
L
F
S
-
C
-
S
I
A
E
N
I
A
Y
G
A
----
D
D
P
S
S
-
V
-
T
A
E
E
I
Q
--
R
V
A
E
V
A
-----
N
A
V
A
F
-----
I
R
---
N
F
--
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
-
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
-
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
--
Q
E
A
L
D
R
L
--
M
-
D
--
G
-
R
T
V
L
V
I
A
H
R
L
-
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
-
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
------------------
87
PsiBlast_CBE
57.08
31%
-35
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[20-232]
----------------------------------
L
N
---
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
---
P
D
----
S
G
E
I
S
L
S
G
K
T
I
-----------
F
S
-----------------
K
N
T
N
L
P
V
----
R
----
E
R
----
R
L
G
Y
L
V
Q
E
G
----
V
--
L
F
P
-
H
L
T
V
Y
R
N
I
A
Y
G
-----
L
G
N
G
K
-
G
-
R
T
A
Q
E
R
--
Q
R
I
E
A
M
----
L
E
L
T
G
I
-----
S
E
---
L
A
--
G
R
Y
P
H
--------
E
-
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
-
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R-
E
D
M
I
A
A
L
--
R
A
N
--
G
-
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
-
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
-
D
---------------
53
PsiBlast_CBE
56.07
32%
-35
- C1 -
4AYT
2
ABCBA_HUMAN
A:
[360-567]
----------------------------------
F
Q
---
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
---
V
L
S
L
L
L
R
L
-
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
------------------------------
R
Q
L
N
P
V
W
----
L
----
R
S
----
K
I
G
T
V
S
Q
E
P
----
I
--
L
F
S
-
C
-
S
I
A
E
N
I
A
Y
G
A
----
D
D
P
S
S
-
V
-
T
A
E
E
I
Q
--
R
V
A
E
V
A
-----
N
A
V
A
F
-----
I
R
---
N
F
--
P
Q
G
F
N
T
VVGE
K
G
V
L
-
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
-
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
--
Q
E
A
L
D
R
L
--
M
-
D
--
G
-
R
T
V
L
V
I
A
H
R
L
-
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
-
G
K
I
T
E
Y
G
K
H
E
E
-----------------------
88
PsiBlast_CBE
55.12
31%
-39
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[20-237]
----------------------------------
L
N
---
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
---
P
D
----
S
G
E
I
S
L
S
G
K
T
I
-----------
F
S
-----------------
K
N
T
N
L
P
V
----
R
----
E
R
----
R
L
G
Y
L
V
Q
E
G
----
V
--
L
F
P
-
H
L
T
V
Y
R
N
I
A
Y
G
-----
L
G
N
G
K
-
G
-
R
T
A
Q
E
R
--
Q
R
I
E
A
M
----
L
E
L
T
G
I
-----
S
E
---
L
A
--
G
R
Y
P
H
--------
E
-
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
-
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
-
E
D
M
I
A
A
L
--
R
A
N
--
G
-
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
-
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
-
D
---------------
50
PsiBlast_CBE
54.09
35%
5
- C1 -
4FWI
2
?
B:
[19-256]
-----------------------
G
----
T
I
K
A
--
A
D
---
G
I
S
L
D
I
L
E
N
S
V
T
A
I
V
G
E
S
A
S
G
K
S
T
I
I
E
A
M
T
K
--
T
L
-
P
P
N
G
R
I
L
S
G
R
V
L
Y
K
G
K
D
L
-----------
L
T
-----------------
M
R
E
E
--
E
----
L
----
R
K
IRWK
E
I
A
L
V
P
Q
A
A
QQSL
N
--
P
T
--
M
-
K
V
I
E
H
F
K
D
T
V
----
E
A
H
G
V
-
R
W
S
H
S
E
L
I
--
E
K
A
S
E
K
----
L
R
M
V
R
L
-----
N
P
---
E
A
--
V
--
L
N
S
----
Y
P
L
Q
-
L
S
G
G
M
K
Q
R
V
L
I
A
L
A
L
L
L
-
D
P
V
V
L
I
L
D
E
P
T
S
A
L
D
V
L
T
Q
A
H
I
IQ
L
L
K
E
L
K
K
--
M
-
L
--
K
-
I
T
L
I
F
V
T
H
D
I
A
V
A
A
E
L
A
D
K
V
A
V
I
Y
G
-
G
N
L
V
E
Y
N
S
T
F
Q
I
F
K
N
P
------------------
93
PsiBlast_CBE
53.58
31%
-69
- C1 -
2PMK
1
A:
[21-231]
----------------------------------
L
D
---
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
------
I
P
-
E
N
G
Q
V
L
I
D
G
H
D
L
-----------
A
L
-------------------
A
D
P
N
W
----
L
----
R
R
----
Q
V
G
V
V
L
Q
D
N
----
V
--
L
L
N
-
R
-
S
I
I
D
N
I
S
L
A
-------------
N
P
G
M
S
V
--
E
K
V
I
Y
A
----
A
K
L
A
G
A
-----
H
D
F
I
S
E
L
--
R
E
G
Y
N
T
IVGE
Q
G
A
G
-
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
-
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
--
M
R
N
M
H
K
I
--
C
-
K
--
G
-
R
T
V
I
I
I
A
H
R
L
-
S
T
V
K
N
A
D
R
I
I
V
M
E
K
-
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
-----------------
49
PsiBlast_CBE
53.38
36%
-15
- C1 -
3TIF
7
Y796_METJA
A:
[19-223]
------------------------------
Y
A
--
L
K
---
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
-
T
------
E
G
E
V
Y
I
D
--
N
I
-----------
K
T
-----------------
N
D
L
D
D
D
E
----
L
T
K
I
R
R
D
----
K
I
G
F
V
F
Q
Q
F
----
N
--
L
I
P
-
L
L
T
A
L
E
N
V
E
L
-
P
----
L
I
F
K
Y
-
R
-
G
A
M
S
G
E
--
E
R
R
K
R
A
----
L
E
C
L
K
M
-----
A
----
E
L
--
E
E
R
F
A
N
----
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
--
M
Q
L
L
K
K
L
N
E
E
-
D
--
G
-
K
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
-------------------------------
94
PsiBlast_CBE
51.75
31%
-66
- C1 -
2FF7
1
A:
[25-235]
----------------------------------
L
D
---
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
------
I
P
-
E
N
G
Q
V
L
I
D
G
H
D
L
-----------
A
L
-------------------
A
D
P
N
W
----
L
----
R
R
----
Q
V
G
V
V
L
Q
D
N
----
V
--
L
L
N
-
R
-
S
I
I
D
N
I
S
L
A
-------------
N
P
G
M
S
V
--
E
K
V
I
Y
A
----
A
K
L
A
G
A
-----
H
D
F
I
S
E
L
--
R
E
G
Y
N
T
IVGE
Q
G
A
G
-
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
-
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
--
M
R
N
M
H
K
I
--
C
-
K
--
G
-
R
T
V
I
I
I
A
H
R
L
-
S
T
V
K
N
A
D
R
I
I
V
M
E
K
-
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
-----------------
47
PsiBlast_CBE
49.55
36%
-8
- C1 -
1L2T
4
Y796_METJA
A:
[19-223]
------------------------------
Y
A
--
L
K
---
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
-
T
------
E
G
E
V
Y
I
D
--
N
I
-----------
K
T
-----------------
N
D
L
D
D
D
E
----
L
T
K
I
R
R
D
----
K
I
G
F
V
F
Q
Q
F
----
N
--
L
I
P
-
L
L
T
A
L
E
N
V
E
L
-
P
----
L
I
F
K
Y
-
R
-
G
A
M
S
G
E
--
E
R
R
K
R
A
----
L
E
C
L
K
M
-----
A
----
E
L
--
E
E
R
F
A
N
----
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
--
M
Q
L
L
K
K
L
N
E
E
-
D
--
G
-
K
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
-------------------------------
46
PsiBlast_CBE
48.82
36%
-9
- C1 -
1L2T
4
Y796_METJA
B:
[19-223]
------------------------------
Y
A
--
L
K
---
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
-
T
------
E
G
E
V
Y
I
D
--
N
I
-----------
K
T
-----------------
N
D
L
D
D
D
E
----
L
TKIR
R
D
----
K
I
G
F
V
F
Q
Q
F
----
N
--
L
I
P
-
L
L
T
A
L
E
N
V
E
L
-
P
----
L
I
F
K
Y
-
R
-
G
A
M
S
G
E
--
E
R
R
K
R
A
----
L
E
C
L
K
M
-----
A
----
E
L
--
E
E
R
F
A
N
----
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
--
M
Q
L
L
K
K
L
NE
E
-
D
--
G
-
K
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
-------------------------------
91
PsiBlast_CBE
47.88
32%
22
- C1 -
2HYD
3
Y1866_STAAM
B:
[335-564]
--------
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
----
D
N
E
A
PI
L
K
---
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
-
T
------
S
G
Q
I
L
I
D
G
H
N
I
------------
K
-----------------
D
F
L
T
-
G
S
----
L
----
R
N
----
Q
I
G
L
V
Q
Q
D
N
----
I
--
L
F
S
-
D
-
T
V
K
E
N
I
L
L
G
-----
R
P
T
A
T
-
D
------
E
--
E
V
V
E
A
A
KMAN
A
H
D
F
I
M
NLPQG
Y
D
T--
E
V
--
G
E
R
--------
G
V
K
-
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
-
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
--
Q
E
A
L
D
V
L
--
S
-
K
--
D
-
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
-
G
H
I
V
E
T
G
T
H
R
E
L
I
A
--------------------
92
PsiBlast_CBE
47.72
32%
21
- C1 -
2HYD
3
Y1866_STAAM
A:
[335-564]
--------
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
----
D
N
E
A
PI
L
K
---
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
-
T
------
S
G
Q
I
L
I
D
G
H
N
I
------------
K
-----------------
D
F
L
T
-
G
S
----
L
----
R
N
----
Q
I
G
L
V
Q
Q
D
N
----
I
--
L
F
S
-
D
-
T
V
K
E
N
I
L
L
G
-----
R
P
T
A
T
-
D
------
E
--
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
LPQG
Y
D
T--
E
V
--
G
E
R
--------
G
V
K
-
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
-
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
--
Q
E
A
L
D
V
L
--
S
-
K
--
D
-
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
-
G
H
I
V
E
T
G
T
H
R
E
L
I
A
--------------------
90
PsiBlast_CBE
47.02
32%
22
- C1 -
2ONJ
4
Y1866_STAAM
A:
[335-564]
--------
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
----
D
N
E
A
PI
L
K
---
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
-
T
------
S
G
Q
I
L
I
D
G
H
N
I
------------
K
-----------------
D
F
L
T
-
G
S
----
L
----
R
N
----
Q
I
G
L
V
Q
Q
D
N
----
I
--
L
F
S
-
D
-
T
V
K
E
N
I
L
L
G
-----
R
P
T
A
T
-
D
------
E
--
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
NLPQG
Y
D
T--
E
V
--
G
E
R
--------
G
V
K
-
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
-
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
--
Q
E
A
L
D
V
L
--
S
-
K
--
D
-
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
-
G
H
I
V
E
T
G
T
H
R
E
L
I
A
--------------------
48
PsiBlast_CBE
46.39
36%
-16
- C1 -
3TIF
6
Y796_METJA
B:
[19-223]
------------------------------
Y
A
--
L
K
---
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
-
T
------
E
G
E
V
Y
I
D
--
N
I
-----------
K
T
-----------------
N
D
L
D
D
D
E
----
L
TKIR
R
D
----
K
I
G
F
V
F
Q
Q
F
----
N
--
L
I
P
-
L
L
T
A
L
E
N
V
E
L
-
P
----
L
I
F
K
Y
-
R
-
G
A
M
S
G
E
--
E
R
R
K
R
A
----
L
E
C
L
K
M
-----
A
----
E
L
--
E
E
R
F
A
N
----
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
--
M
Q
L
L
K
K
L
NE
E
-
D
--
G
-
K
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
-------------------------------
89
PsiBlast_CBE
46.32
32%
22
- C1 -
2ONJ
4
Y1866_STAAM
B:
[335-564]
--------
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
N
----
D
N
E
A
PI
L
K
---
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
-
T
------
S
G
Q
I
L
I
D
G
H
N
I
------------
K
-----------------
D
F
L
T
-
G
S
----
L
----
R
N
----
Q
I
G
L
V
Q
Q
D
N
----
I
--
L
F
S
-
D
-
T
V
K
E
N
I
L
L
G
-----
R
P
T
A
T
-
D
------
E
--
E
V
V
E
A
A
KMAN
A
H
D
F
I
M
NLPQG
Y
D
T--
E
V
--
G
E
R
--------
G
V
K
-
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
-
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
--
Q
E
A
L
D
V
L
--
S
-
K
--
D
-
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
-
G
H
I
V
E
T
G
T
H
R
E
L
I
A
--------------------
96
PsiBlast_CBE
38.06
31%
-35
- C1 -
3VX4
3
?
D:
[51-248]
----------------------------------
L
S
---
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
---
L
I
V
N
F
Y
E
P
N
----
K
G
I
V
R
I
N
G
N
D
L
------------------------------
K
V
I
D
K
T
A
----
L
----
R
R
----
H
I
S
Y
L
P
Q
Q
A
----
Y
--
V
F
S
-
G
-
S
I
M
D
N
L
V
L
G
A
----
K
-
E
G
T
-
S
-
Q
E
D
I
I
R
AC
E
I
A
E
I
R
-----
S
D
I
E
Q
-----
M
P
---
Q
G
--
Y
Q
T
E
L
S
----
D
G
A
G
-
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
-
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
--
I
S
N
L
L
Q
M
--
T
-
E
--
K
--
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
-
T
D
E
V
I
V
M
D
Q
-
G
K
I
V
E
-----------------------------
97
PsiBlast_CBE
38.05
31%
-36
- C1 -
3VX4
3
?
A:
[51-248]
----------------------------------
L
S
---
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
---
L
I
V
N
F
Y
E
P
N
----
K
G
I
V
R
I
N
G
N
D
L
------------------------------
K
V
I
D
K
T
A
----
L
----
R
R
----
H
I
S
Y
L
P
Q
Q
A
----
Y
--
V
F
S
-
G
-
S
I
M
D
N
L
V
L
G
A
----
K
-
E
G
T
-
S
-
Q
E
D
I
I
R
A
C
E
I
A
E
I
R
-----
S
D
I
E
Q
-----
M
P
---
Q
G
--
Y
Q
T
E
L
S
----
D
G
A
G
-
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
-
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
--
I
S
N
L
L
Q
M
--
T
-
E
--
K
--
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
-
T
D
E
V
I
V
M
D
Q
-
G
K
I
V
E
-----------------------------