@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu25560: (2016-07-10 )
MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQETKDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSALESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAKTEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQNIFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQKQIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLLQLLKRNEKNDPHY
Atome Classification :
(20 SA)
------------------------------.........10........20........30.......----------------.40...------------------.------------------.-----------------...50....------.-----.---.---.----60........------.70---------------..-..-....80........90........100......-.110........120....---...130.......---140......--.150......-------.160---.-------......-.-.170.......180.......190......---.----200.......210..---.....220......----.230.......-240-.--......250.......260.......270.......280.......290.......300.......310.......320..-......330.......340.....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------
M
V
F
D
V
W
K
S
LKKGEV
H
P
V
Y
C
L
YGK
E
T
Y
L
L
Q
E
T
V
S
R
I
R
Q
T
----------------
V
VDQET------------------K------------------D-----------------F
N
L
S
V
F
DLE------E-----D---
P
---
L
----
D
-
Q
A
IADAET------FPF---------------MG-
E
R
-
R
L
V
I
VKN
P
Y
F
LT
G
E
K
K
K
E
K
I
E
H
N
V
S
A
L
E
S
Y
I
QS-PA
P
-
Y
T
V
F
V
L
LA
P
Y
E
K
L
D
E
---
R
K
K
L
T
K
A
L
K
K
H
A
F
---
M
M
E
A
K
ELNA--KETT
D
F
T
V
N
L-------AK-----T-------
E
Q
K
TI
G
-
T
-
E
A
A
E
H
L
V
L
L
VN
G
H
L
S
S
I
F
Q
E
I
Q
K
L
C
T
F
IGD---R----EEI
T
L
D
D
V
K
M
L
V
A
R
S
---
L
E
Q
N
I
F
E
L
I
N
K
I
V
N----RKRT
E
S
L
Q
I
F
Y
-
D
L
L
-K--QNEEP
I
K
I
M
A
L
ISN
Q
F
R
L
I
L
Q
T
K
Y
F
A
EQGY
G
Q
K
Q
I
A
SNLKV
H
P
F
R
V
K
L
A
M
D
Q
A
R
LF
S
E
E
E
L
R
L
I
I
E
Q
L
A
V
M
D
Y
EMKT-GK
K
-
D
K
Q
L
L
L
E
L
F
L
L
Q
L
L
KRNEKNDPHY-
26
Fugue
90.47
100%
-130
- C2 -
3ZH9
14
YQEN_BACSU
B:
[1-339]
------------------------------
M
V
F
D
V
W
K
S
L
K
K
G
E
V
H
P
V
Y
C
L
Y
G
K
E
T
Y
L
L
Q
E
T
V
S
R
I
R
Q
T
----------------
V
V
D
Q
E
T
------------------
K
------------------
D
-----------------
F
N
L
S
V
F
D
L
E
------
E
-----
D
---
P
---
L
----
D
-
Q
A
I
A
D
A
E
T
------
F
P
F
---------------
M
G
-
E
R
-
R
L
V
I
V
K
N
P
Y
F
L
T
G
E
K
K
K
E
K
I
E
H
N
V
S
A
L
E
S
Y
I
Q
S
-
P
A
P
-
Y
T
V
F
V
L
L
A
P
Y
E
K
L
D
E
---
R
K
K
L
T
K
A
L
K
K
H
A
F
---
M
M
E
A
K
E
L
N
A
--
K
E
T
T
D
F
T
V
N
L
-------
A
K
-----
T
-------
E
Q
K
T
I
G
-
T
-
E
A
A
E
H
L
V
L
L
V
N
G
H
L
S
S
I
F
Q
E
I
Q
K
L
C
T
F
I
G
D
---
R
----
E
E
I
T
L
D
D
V
K
M
L
V
A
R
S
---
L
E
Q
N
I
F
E
L
I
N
K
I
V
N
----
R
K
R
T
E
S
L
Q
I
F
Y
-
D
L
L
-
K
--
Q
N
E
E
P
I
K
I
M
A
L
I
S
N
Q
F
R
L
I
L
Q
T
K
Y
F
A
E
Q
G
Y
G
Q
K
Q
I
A
S
N
L
K
V
H
P
F
R
V
K
L
A
M
D
Q
A
R
L
F
S
E
E
E
L
R
L
I
I
E
Q
L
A
V
M
D
Y
E
M
K
T
-
G
K
K
-
D
K
Q
L
L
L
E
L
F
L
L
Q
L
L
K
R
---------
6
HHSearch
90.47
100%
-130
- C2 -
3ZH9
14
YQEN_BACSU
B:
[1-339]
------------------------------
M
V
F
D
V
W
K
S
L
K
K
G
E
V
H
P
V
Y
C
L
Y
G
K
E
T
Y
L
L
Q
E
T
V
S
R
I
R
Q
T
----------------
V
V
D
Q
E
T
------------------
K
------------------
D
-----------------
F
N
L
S
V
F
D
L
E
------
E
-----
D
---
P
---
L
----
D
-
Q
A
I
A
D
A
E
T
------
F
P
F
---------------
M
G
-
E
R
-
R
L
V
I
V
K
N
P
Y
F
L
T
G
E
K
K
K
E
K
I
E
H
N
V
S
A
L
E
S
Y
I
Q
S
-
P
A
P
-
Y
T
V
F
V
L
L
A
P
Y
E
K
L
D
E
---
R
K
K
L
T
K
A
L
K
K
H
A
F
---
M
M
E
A
K
E
L
N
A
--
K
E
T
T
D
F
T
V
N
L
-------
A
K
-----
T
-------
E
Q
K
T
I
G
-
T
-
E
A
A
E
H
L
V
L
L
V
N
G
H
L
S
S
I
F
Q
E
I
Q
K
L
C
T
F
I
G
D
---
R
----
E
E
I
T
L
D
D
V
K
M
L
V
A
R
S
---
L
E
Q
N
I
F
E
L
I
N
K
I
V
N
----
R
K
R
T
E
S
L
Q
I
F
Y
-
D
L
L
-
K
--
Q
N
E
E
P
I
K
I
M
A
L
I
S
N
Q
F
R
L
I
L
Q
T
K
Y
F
A
E
Q
G
Y
G
Q
K
Q
I
A
S
N
L
K
V
H
P
F
R
V
K
L
A
M
D
Q
A
R
L
F
S
E
E
E
L
R
L
I
I
E
Q
L
A
V
M
D
Y
E
M
K
T
-
G
K
K
-
D
K
Q
L
L
L
E
L
F
L
L
Q
L
L
K
R
---------
1
PsiBlast_PDB
90.47
100%
-130
- C2 -
3ZH9
14
YQEN_BACSU
B:
[1-339]
------------------------------
M
V
F
D
V
W
K
S
L
K
K
G
E
V
H
P
V
Y
C
L
Y
G
K
E
T
Y
L
L
Q
E
T
V
S
R
I
R
Q
T
----------------
V
V
D
Q
E
T
------------------
K
------------------
D
-----------------
F
N
L
S
V
F
D
L
E
------
E
-----
D
---
P
---
L
----
D
-
Q
A
I
A
D
A
E
T
------
F
P
F
---------------
M
G
-
E
R
-
R
L
V
I
V
K
N
P
Y
F
L
T
G
E
K
K
K
E
K
I
E
H
N
V
S
A
L
E
S
Y
I
Q
S
-
P
A
P
-
Y
T
V
F
V
L
L
A
P
Y
E
K
L
D
E
---
R
K
K
L
T
K
A
L
K
K
H
A
F
---
M
M
E
A
K
E
L
N
A
--
K
E
T
T
D
F
T
V
N
L
-------
A
K
-----
T
-------
E
Q
K
T
I
G
-
T
-
E
A
A
E
H
L
V
L
L
V
N
G
H
L
S
S
I
F
Q
E
I
Q
K
L
C
T
F
I
G
D
---
R
----
E
E
I
T
L
D
D
V
K
M
L
V
A
R
S
---
L
E
Q
N
I
F
E
L
I
N
K
I
V
N
----
R
K
R
T
E
S
L
Q
I
F
Y
-
D
L
L
-
K
--
Q
N
E
E
P
I
K
I
M
A
L
I
S
N
Q
F
R
L
I
L
Q
T
K
Y
F
A
E
Q
G
Y
G
Q
K
Q
I
A
S
N
L
K
V
H
P
F
R
V
K
L
A
M
D
Q
A
R
L
F
S
E
E
E
L
R
L
I
I
E
Q
L
A
V
M
D
Y
E
M
K
T
-
G
K
K
-
D
K
Q
L
L
L
E
L
F
L
L
Q
L
L
K
R
---------
9
HHSearch
53.16
13%
14
* C2 *
1JR3
2
DPO3X_ECOLI
A:
[27-361]
---------------------------------
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
----------------
L
N
C
E
T
G
------------------
I
TATPCGVC
D
N
C
R
E
I
E
Q
GR
F
-----------------
V
D
L
I
E
I
D
A
A
------
S
RTKV-
E
---
D
---
T
----
R
-
D
L
L
D
N
V
Q
Y
------
A
P
A
---------------
R
G
-
R
F
-
K
V
Y
L
I
D
E
V
H
M
L
S
R
--------
H
S
F
N
A
L
L
K
T
L
E
E
-
P
P
E
-
H
V
K
F
L
L
A
T
T
--
D
P
------
Q
K
L
P
V
T
I
L
S
R
C
L
---
Q
F
H
L
K
A
L
D
V
--
E
Q
I
R
H
Q
L
E
H
I
-------
L
N
-----
E
-------
E
H
I
A
H
E
-
P
-
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
---------
Q
V
S
T
Q
A
V
S
A
M
L
G
T
L
---
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
----
A
N
G
E
R
V
M
A
L
I
N
-
E
A
A
-
A
--
R
G
I
E
W
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
------
A
A
L
G
N
D
M
A
---
A
I
E
L
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
-
A
P
--
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
F
H
P
-------
7
HHSearch
52.48
16%
-68
- C2 -
1JR3
-
HOLA_ECOLI
D:
[7-336]
--------------------------------
E
Q
L
R
A
Q
L
N
E
G
-
L
R
A
A
Y
L
L
L
G
N
D
P
L
L
L
Q
E
S
Q
D
A
V
R
Q
V
----------------
A
A
A
Q
G
F
------------------
E
------------------
E
-----------------
H
H
T
F
S
I
D
P
N
------
T
---------
D
---
W
----
N
-
A
I
F
S
L
C
Q
A
------
M
S
L
---------------
F
A
-
S
R
-
Q
T
L
L
L
L
L
P
E
N
G
P
N
-------
A
A
I
N
E
Q
L
L
T
L
T
G
L
-
L
H
D
-
D
L
L
L
I
V
R
G
N
--
K
L
S
K
AQE
N
A
A
W
F
T
A
L
A
N
R
S
V
---
Q
V
T
C
Q
T
P
E
Q
--
A
Q
L
P
R
W
V
A
A
R
-------
A
K
-----
Q
-------
L
N
L
E
L
D
-
D
-
A
A
N
Q
V
L
C
Y
C
Y
E
G
N
L
L
A
L
A
Q
A
L
E
R
L
S
L
L
W
P
D
---
G
-----
K
L
T
L
P
R
V
E
Q
A
V
N
D
A
---
A
H
F
T
P
F
H
W
V
D
A
L
L
M
----
G
K
S
K
R
A
L
H
I
L
Q
-
Q
L
R
-
L
--
E
G
S
E
P
V
I
L
L
R
T
L
Q
R
E
L
L
L
L
V
N
L
K
R
Q
S
A
-
H
T
P
L
R
A
L
F
D
K
H
R
V
W
Q
N
R
R
G
M
M
G
E
A
L
N
R
L
S
Q
T
Q
L
R
Q
A
V
Q
L
L
T
R
T
E
L
T
L
K
Q
-
D
Y
G
Q
S
V
W
A
E
L
E
G
L
S
L
L
L
C
H
K
P
L
-------
29
Fugue
49.71
11%
13
- C2 -
1JR3
2
DPO3X_ECOLI
A:
[3-368]
---------YQV
L
A
R
K
W
RPQTFADVVGQ
E
H
V
L
T
A
L
A
N
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
L
N
CETGITATPCGVC
D
N
C
R
E
I
E
------------------
Q
------------------
G
-----------------
R
F
V
D
L
I
E
I
D
AASRTK
V
-----
E
---
D
---
T
----
R
-
D
L
L
D
N
V
Q
Y
------
A
P
A
---------------
R
G
-
R
F
-
K
V
Y
L
I
D
E
V
H
M
L
S
--------
R
H
S
F
N
A
L
L
K
T
L
E
E
-
P
P
E
-
H
V
K
F
L
L
A
T
-----
T
D
---
P
Q
K
L
P
V
T
I
L
S
R
C
L
---
Q
F
H
L
K
A
L
D
V
--
E
Q
I
R
H
Q
L
E
H
I
-------
L
N
-----
E
-------
E
H
I
A
H
E
-
P
-
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
G
---
Q
------
V
S
T
Q
A
V
S
A
M
L
G
T
L
---
D
D
D
Q
A
L
S
L
V
E
A
M
V
E
----
A
N
G
E
R
V
M
A
L
I
N
-
E
A
A
-
A
--
R
G
I
E
W
E
A
L
L
V
E
M
L
G
L
L
H
R
I
A
M
V
Q
L
S
P
A
A
L
G
N
D
M
A
A
I
---------
E
L
R
M
R
E
L
A
R
T
I
P
P
T
D
I
Q
L
Y
Y
Q
T
L
L
I
G
R
K
E
L
P
Y
--
A
P
-
D
R
R
M
G
V
E
M
T
L
L
R
A
L
A
F
H
P
R
M
P
L
P
E
P
27
Fugue
47.51
15%
-2
- C2 -
1JQJ
-
HOLA_ECOLI
C:
[1-333]
---------------------------M
I
R
L
Y
P
E
Q
L
R
A
Q
L
N
E
G
L
R
A
A
Y
L
L
L
G
N
D
P
L
L
L
Q
E
S
Q
D
A
V
R
Q
V
----------------
A
A
A
Q
G
F
------------------
E
------------------
E
-----------------
H
H
T
F
S
I
D
-
P
------
N
-----
T
---
D
---
W
----
N
-
A
I
F
S
L
C
Q
A
------
M
S
L
---------------
F
A
-
S
R
-
Q
T
L
L
L
L
L
P
E
N
G
P
N
A
A
I
N
E
Q
L
L
T
L
T
G
------
L
L
-
H
D
D
-
L
L
L
I
V
R
G
N
K
L
S
K
A
Q
E
---
N
A
A
W
F
T
A
L
A
N
R
S
V
---
Q
V
T
C
Q
T
P
E
Q
--
A
Q
L
P
R
W
V
A
A
R
-------
A
K
-----
Q
-------
L
N
L
E
L
D
-
D
-
A
A
N
Q
V
L
C
Y
C
Y
E
G
N
L
L
A
L
A
Q
A
L
E
R
L
S
L
L
W
P
D
---
G
----
K
-
L
T
L
P
R
V
E
Q
A
V
N
D
A
---
A
H
F
T
P
F
H
W
V
D
A
L
L
M
----
G
K
S
K
R
A
L
H
I
L
Q
-
Q
L
R
-
L
--
E
G
S
E
P
V
I
L
L
R
T
L
Q
R
E
L
L
L
L
V
N
L
K
R
Q
S
A
H
T
P
L
R
A
L
F
D
K
H
---
R
V
W
R
R
G
M
M
G
E
A
L
N
R
L
S
Q
T
Q
L
R
Q
A
V
Q
L
L
T
R
T
E
L
T
L
K
Q
-
D
Y
G
-
Q
A
E
L
--
E
G
L
S
L
L
L
C
H
----------
15
HHSearch
46.72
14%
19
- C2 -
2CHQ
1
RFCS_ARCFU
A:
[37-316]
-------------------------------------------
N
I
P
H
L
L
F
S
G
P
P
G
T
G
K
T
A
T
A
I
A
L
A
R
D
----------------
L
F
G
E
-
N
------------------
W
------------------
R
-----------------
D
N
F
I
E
M
N
A
S
------
D
ERGID
V
---
V
---
R
----
H
-
K
I
K
E
F
A
R
T
------
A
P
I
---------------
G
G
A
P
F
-
K
I
I
F
L
D
E
A
D
A
L
T
A
--------
D
A
Q
A
A
L
R
R
T
M
E
M
-
Y
S
K
-
S
C
R
F
I
L
S
C
N
--
Y
------
V
S
R
I
I
E
P
I
Q
S
R
C
A
---
V
F
R
F
K
P
V
P
K
--
E
A
M
K
K
R
L
L
E
I
-------
C
E
-----
K
-------
E
G
V
K
I
T
-
E
-
D
G
L
E
A
L
I
Y
I
S
G
G
D
F
R
K
A
I
N
A
L
Q
G
A
A
A
I
G
E
----------
V
V
D
A
D
T
I
Y
Q
I
T
A
T
A
---
R
P
E
E
M
T
E
L
I
Q
T
A
L
K
----
G
N
F
M
E
A
R
E
L
L
D
-
R
L
M
-
V
E-
Y
G
M
S
G
E
D
I
V
A
Q
L
F
R
E
I
I
S
M
P
-
I
K
----------------------------------
D
S
L
K
V
Q
L
I
D
K
L
G
E
V
D
F
R
L
T
E
-
G
A
N
--
E
R
I
Q
L
D
A
Y
L
A
Y
L
S
T
L
---------
11
HHSearch
46.46
16%
33
- C2 -
1SXJ
4
RFC3_YEAST
C:
[37-333]
----------------------------------
V
R
K
F
V
D
E
-
G
K
L
P
H
L
L
F
Y
G
P
P
G
T
G
K
T
S
T
I
V
A
L
A
R
E
----------------
I
Y
G
K
-
N
------------------
Y
------------------
S
-----------------
N
M
V
L
E
L
N
A
S
------
D
D
R
G
I
D
V
---
V
---
R
----
N
-
Q
I
K
D
F
A
S
T
------
R
Q
I
---------------
F
S
K
G
F
-
K
L
I
I
L
D
E
A
D
A
M
T
N
--------
A
A
Q
N
A
L
R
R
V
I
E
R
-
Y
T
K
-
N
T
R
F
C
V
L
A
N
--
Y
------
A
H
K
L
T
P
A
L
L
S
Q
C
T
---
R
F
R
F
Q
P
L
P
Q
--
E
A
I
E
R
R
I
A
N
V
-------
L
V
-----
H
-------
E
K
L
K
L
S
-
P
-
N
A
E
K
A
L
I
E
L
S
N
G
D
M
R
R
V
L
N
V
L
Q
S
C
K
A
T
L
D
N
PD-
E
----
D
E
I
S
D
D
V
I
Y
E
C
C
G
A
P
---
R
P
S
D
L
K
A
V
L
K
S
I
L
E
----
D
D
W
G
T
A
H
Y
T
L
N
-
K
V
R
-
S
A
-
K
G
L
A
L
I
D
L
I
E
G
I
V
K
I
L
E
D
Y
E
L
----------------------------------
Q
N
E
E
T
R
V
H
L
L
T
K
L
A
D
I
E
Y
S
I
S
K
-
G
G
--
N
D
Q
I
Q
G
S
A
V
I
G
A
I
K
A
S
F
E
N
------
12
HHSearch
46.39
13%
-3
- C2 -
1SXJ
3
RFC5_YEAST
E:
[27-351]
-----------------------------------
K
S
L
S
D
Q
P
R
D
L
P
H
L
L
L
Y
G
P
N
G
T
G
K
K
T
R
C
M
A
L
L
E
S
----------------
I
F
G
P
G
V
------------------
Y
------------------
R
NVVSS------------
P
Y
H
L
E
I
T
P
S
-------ND
R
--
I
---
V
---
I
----
Q
-
E
L
L
K
E
V
A
Q
MEQ------------------------
R
Y
-
K
C
V
I
I
N
E
A
N
S
L
T
K
--------
D
A
Q
A
A
L
R
R
T
M
E
K
-
Y
S
K
-
N
I
R
L
I
M
V
C
D
--
S
M
------
S
P
I
I
A
P
I
K
S
Q
C
L
---
L
I
R
C
P
A
P
S
D
--
S
E
I
S
T
I
L
S
D
V
-------
V
T
-----
N
-------
E
R
I
Q
L
E
T
K
-
D
I
L
K
R
I
A
Q
A
S
N
G
N
L
R
V
S
L
L
M
L
E
S
M
A
L
N
N
E
-----------
L
A
L
K
S
S
S
P
I
I
K
P
D
---
W
I
I
V
I
H
K
L
T
R
K
I
V
K
ERS
V
N
S
L
I
E
C
R
A
V
L
Y
-
D
L
L
-
A
--
H
C
I
P
A
N
I
I
L
K
E
L
T
F
S
L
L
----------------------------------
D
V
E
T
L
N
T
T
N
K
S
S
I
I
E
Y
S
S
V
F
D
E
R
L
S
L
-
G
N
--
K
A
I
F
H
L
E
G
F
I
A
K
V
M
C
----------
17
HHSearch
46.37
16%
10
- C2 -
1SXJ
4
RFC4_YEAST
B:
[32-320]
---------------------------------
R
L
Q
Q
I
A
K
D
G
-
N
M
P
H
M
I
I
S
G
M
P
G
I
G
K
T
T
S
V
H
C
L
A
H
E
----------------
L
L
G
R
-
S
------------------
Y
------------------
A
-----------------
D
G
V
L
E
L
N
A
S
------
D
-----
D
R--
G
---
I
----
D
-
V
V
R
N
Q
I
K
H
F
A
Q
K
K
L
H
L
P
---------------
P
G
-
K
H
-
K
I
V
I
L
D
E
A
D
S
M
T
A
--------
G
A
Q
Q
A
L
R
R
T
M
E
L
-
Y
S
N
-
S
T
R
F
A
F
A
C
N
--
Q
S
------
N
K
I
I
E
P
L
Q
S
Q
C
A
---
I
L
R
Y
S
K
L
S
D
--
E
D
V
L
K
R
L
L
Q
I
-------
I
K
-----
L
-------
E
D
V
K
Y
T
-
N
-
D
G
L
E
A
I
I
F
T
A
E
G
D
M
R
Q
A
I
N
N
L
Q
S
T
V
A
G
H
G
----------
L
V
N
A
D
N
V
F
K
I
V
D
S
P
------
H
P
L
I
V
K
K
M
L
L
A
----
S
N
L
E
D
S
I
Q
I
L
R
T
D
L
W
-
K
--
K
G
Y
S
S
I
D
I
V
T
T
S
F
R
V
T
K
N
L
A
Q
V
K
E
S
----------------------------------
V
R
L
E
M
I
K
E
I
G
L
T
H
M
R
I
L
E
-
G
V
G
--
T
Y
L
Q
L
A
S
M
L
A
K
I
H
K
L
N
--------
13
HHSearch
45.95
14%
-9
- C2 -
1SXJ
3
RFC2_YEAST
D:
[49-352]
----------------------------------
L
K
K
T
L
K
S
-
A
N
L
P
H
M
L
F
Y
G
P
P
G
T
G
K
T
S
T
I
L
A
L
T
K
E
----------------
L
Y
G
P
D
L
------------------
M
------------------
K
-----------------
S
R
I
L
E
L
N
A
S
------
D
-----
E
R--
G
---
I
----
S
-
I
V
R
E
K
V
K
N
------
F
A
R
L
T
V
S
K
P
S
K
H
D
L
E
NYP
C
P
-
P
Y
-
K
I
I
I
L
D
E
A
D
S
M
T
A
--------
D
A
Q
S
A
L
R
R
T
M
E
T
-
Y
S
G
-
V
T
R
F
C
L
I
C
N
--
Y
V
------
T
R
I
I
D
P
L
A
S
Q
C
S
---
K
F
R
F
K
A
L
D
A
--
S
N
A
I
D
R
L
R
F
I
-------
S
E
-----
Q
-------
E
N
V
K
C
D
-
D
-
G
V
L
E
R
I
L
D
I
S
A
G
D
L
R
R
G
I
T
L
L
Q
S
A
S
K
G
A
Q
Y
L
GD
G
----
K
N
I
T
S
T
Q
V
E
E
L
A
G
V
V
---
P
H
D
I
L
I
E
I
V
E
K
V
K
S
----
G
D
F
D
E
I
K
K
Y
V
N
-
T
F
M
-
K
--
S
G
W
S
A
A
S
V
V
N
Q
L
H
E
Y
Y
I
T
N
D
N
----------------------------------
F
D
T
N
F
K
N
Q
I
S
W
L
L
F
T
T
D
S
R
L
N
N
-
G
T
--
N
E
H
I
Q
L
L
N
L
L
V
K
I
S
Q
----------
10
HHSearch
44.00
13%
-3
- C2 -
1A5T
1
HOLB_ECOLI
A:
[11-326]
-------------------------------
F
E
K
L
V
A
S
Y
Q
A
G
R
G
H
H
A
L
L
I
Q
A
L
P
G
M
G
D
D
A
L
I
Y
A
L
S
R
Y
----------------
L
L
C
Q
Q
P
QGHKSCGHC
R
G
C
Q
L
M
Q
A
G
T
------------------
H
-----------------
P
D
Y
Y
T
L
A
P
E
KGKN--
T
LG
V
--
D
---
A
---
V
----
R
-
E
V
T
E
K
L
N
E
------
H
A
R
---------------
L
G
-
G
A
-
K
V
V
W
V
T
D
A
A
L
L
T
D
--------
A
A
A
N
A
L
L
K
T
L
E
E
-
P
P
A
-
E
T
W
F
F
L
A
T
R
--
E
P
------
E
R
L
L
A
T
L
R
S
R
C
R
---
L
H
Y
L
A
P
P
P
E
--
Q
Y
A
V
T
W
L
S
R
------------------------
E
V
T
M
S
-
Q
-
D
A
L
L
A
A
L
R
L
S
A
G
S
P
G
A
A
L
A
L
F
Q
G
D
---------
N
----
W
Q
A
R
E
T
L
C
Q
A
L
A
Y
S
V
---
P
S
G
D
W
Y
S
L
L
A
A
L
N
H
-------------------------
E
Q
A
P
A
R
L
H
W
L
A
T
L
L
M
D
A
L
K
R
-----------------
V
T
N
V
D
V
P
G
L
V
A
E
L
A
N
H
L
S
P
S
R
L
Q
A
I
L
G
D
V
C
H
I
R
E
Q
L
M
S
V
T
G
I
-
N
R
E
L
L
I
T
D
L
L
L
R
I
E
H
Y
L
Q
P
G
-----
16
HHSearch
43.70
14%
12
- C2 -
1IQP
1
RFCS_PYRFU
A:
[37-324]
----------------------------------
L
K
H
Y
V
K
T
-
G
S
M
P
H
L
L
F
A
G
P
P
G
V
G
K
T
T
A
A
L
A
L
A
R
E
----------------
L
F
G
E
-
N
------------------
W
------------------
R
-----------------
H
N
F
L
E
L
N
A
S
------
D
-----
E
R
--
G
I
N
V
I
----
R
E
K
V
K
E
F
A
R
T
------
K
P
I
---------------
G
G
A
S
F
-
K
I
I
F
L
D
E
A
D
A
L
T
Q
--------
D
A
Q
Q
A
L
R
R
T
M
E
M
-
F
S
S
-
N
V
R
F
I
L
S
C
N
--
Y
S
------
S
K
I
I
E
P
I
Q
S
R
C
A
---
I
F
R
F
R
P
L
R
D
--
E
D
I
A
K
R
L
R
Y
I
-------
A
E
-----
N
-------
E
G
L
E
L
T
-
E
-
E
G
L
Q
A
I
L
Y
I
A
E
G
D
M
R
R
A
I
N
I
L
Q
A
A
A
A
L
D
K
----------
K
I
T
D
E
N
V
F
M
V
A
S
R
A
---
R
P
E
D
I
R
E
M
M
L
L
A
L
K
----
G
N
F
L
K
A
R
E
K
L
R
-
E
I
L
L
K
--
Q
G
L
S
G
E
D
V
L
V
Q
M
H
K
E
V
F
N
L
-----------------------------------
P
I
E
E
P
K
K
V
L
L
A
D
K
I
G
E
Y
N
F
R
L
V
E
-
G
A
N
--
E
I
I
Q
L
E
A
L
L
A
Q
F
T
L
I
---------
30
Fugue
42.93
14%
14
- C2 -
1IQP
1
RFCS_PYRFU
A:
[2-327]
SEEI
R
E
V
K
V
L
EKP
W
V
E
K
Y
RPQRLDDIVGQ
E
H
I
V
K
R
L
K
H
Y
V
K
T
G
S
M
P
H
L
L
F
A
G
P
P
G
V
G
K
T
T
A
A
L
A
L
A
R
E
----------------
L
F
G
E
N
W
------------------
R
------------------
H
N
F
L
E
-------------
L
N
A
S
D
E
R
G
I
------
N
-----
V
---
I
---
R
----
E
-
K
V
K
E
F
A
R
T
------
K
P
I
---------------
G
G
-
A
S
F
K
I
I
F
L
D
E
A
D
A
L
T
--------
Q
D
A
Q
Q
A
L
R
R
T
M
E
M
-
F
S
S
-
N
V
R
F
I
L
S
C
N
Y
--------
S
S
K
I
I
E
P
I
Q
S
R
C
A
---
I
F
R
F
R
P
L
R
D
--
E
D
I
A
K
R
L
R
Y
I
-------
A
E
-----
N
-------
E
G
L
E
L
T
-
E
-
E
G
L
Q
A
I
L
Y
I
A
E
G
D
M
R
R
A
I
N
I
L
Q
A
A
A
A
---
L
---
D
----
K
K
I
T
D
E
N
V
F
M
V
A
S
R
A
---
R
P
E
D
I
R
E
M
M
L
L
A
L
K
----
G
N
F
L
K
A
R
E
K
L
R
-
E
I
L
-
L
--
K
Q
--------------------------
G
L
S
G
E
D
V
L
V
Q
M
H
K
E
V
F
N
L
P
I
--------
E
E
P
K
K
V
L
L
A
D
K
I
G
E
Y
N
F
R
L
V
E
-
G
A
--
N
E
I
I
Q
L
E
A
L
L
A
Q
F
T
L
I
G
K
K
------
8
HHSearch
40.51
13%
9
- C2 -
2GNO
3
?
A:
[7-299]
--------------------------------
E
T
L
K
R
I
I
E
K
S
E
-
G
I
S
I
L
I
N
G
E
D
L
S
Y
P
R
E
V
S
L
E
L
P
E
Y
----------------
V
E
K
F
P
P
------------------
K
------------------
A
-----------------
S
D
V
L
E
I
D
P
E
GE----
N
-----
I
G
I
D
D
---
I
----
R
-
T
I
K
D
F
L
N
Y
------
S
P
E
---------------
L
Y
-
T
R
-
K
Y
V
I
V
H
D
C
E
R
M
T
Q
--------
Q
A
A
N
A
F
L
K
A
L
E
E
-
P
P
E
-
Y
A
V
I
V
L
N
T
R
--
R
W
------
H
Y
L
L
P
T
I
K
S
R
V
F
---
R
V
V
V
N
V
P
K
E
F
R
D
L
V
K
E
K
I
G
D
L
-------
W
E
E
L
P
L
L
E
-------
R
D
F
K
T
A
-
L
-
E
A
Y
K
L
G
A
E
K
L
S
G
L
M
E
-
S
L
K
V
L
E
T
E
-------------------
K
L
L
K
K
V
L
S
K
G
L
E
-
G
Y
L
A
C
R
E
L
L
E
R
F
S
K
----
V
E
S
K
E
F
F
A
L
F
D
-
Q
V
T
-
N
T
I
T
G
K
D
A
F
L
L
I
Q
R
L
T
R
I
I
---
L
H
E
N
T
W
E
S
--
V
E
D
Q
K
S
V
S
F
L
--------
D
S
I
L
R
V
K
I
A
N
L
N
N
K
L
T
L
M
N
I
L
A
I
H
R
E
R
K
R
-------------------------------
22
HHSearch
39.59
14%
1
- C2 -
1NJG
3
DPO3X_ECOLI
A:
[38-248]
-------------------------------------
G
L
S
L
G
R
I
H
H
A
Y
L
F
S
G
T
R
G
V
G
K
T
S
I
A
R
L
L
A
K
G
----------------
L
N
C
E
T
G
------------------
I
T-----------------
A
TPCGVC
D
N
C
R
E
I
E
Q
GRF
V
D
L
I
E
I
D
A
A
------
S
RTK
V
-
E
---
D
---
T
----
R
-
D
L
L
D
N
V
Q
Y
------
A
P
A
---------------
R
G
-
R
F
-
K
V
Y
L
I
D
E
V
H
M
L
S
R
--------
H
S
F
N
A
L
L
K
T
L
E
E
-
P
P
E
-
H
V
K
F
L
L
A
T
T
--
D
P
------
Q
K
L
P
V
T
I
L
S
R
C
L
---
Q
F
H
L
K
A
L
D
V
--
E
Q
I
R
H
Q
L
E
H
I
-------
L
N
-----
E
-------
E
H
I
A
H
E
-
P
-
R
A
L
Q
L
L
A
R
A
A
E
G
S
L
R
D
A
L
S
L
T
D
Q
A
I
A
S
G
D
---------
G
Q
V
S
T
Q
A
V
S
A
M
L
------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
38.98
12%
3
- C2 -
3PVS
1
RARA_ECOLI
A:
[40-306]
---------------------------------
P
L
P
R
A
I
E
A
G
H
-
L
H
S
M
I
L
W
G
P
P
G
T
G
K
T
T
L
A
E
V
I
A
R
Y
----------------
A
N
A
D
-----------------------------------------------------------
V
E
R
I
S
A
V
TSG---
V
-----
K
---
E
---
I
----
R
-
E
A
I
E
R
A
R
Q
------
N
R
N
---------------
A
G
-
R
R
-
T
I
L
F
V
D
E
V
H
R
F
--------------
A
F
L
P
H
I
E
D
---
G
-
T
I
T
F
I
G
A
T
T
---
E
N
P
---
S
F
E
L
N
S
A
L
L
S
R
A
R
---
V
Y
L
L
K
S
L
S
T
--
E
D
I
E
Q
V
L
T
Q
A
-------
M
E
-----
D
KTRGYGG
Q
D
I
V
L
P
-
D
-
E
T
R
R
A
I
A
E
L
V
N
G
D
A
R
R
A
L
N
T
L
E
M
M
A
D
M
A
E
V
---
D
DSGK
R
V
L
K
P
E
L
L
T
E
I
A
G
E
R
SAR
K
G
D
R
F
Y
D
L
I
S
A
L
H
K
S
V
R
G
S
A
P
D
A
A
L
Y
W
Y
A
-
R
I
I
-
T
--
A
G
G
D
P
L
Y
V
A
R
R
C
L
----------------------------------------------------------------------------------------------
14
HHSearch
38.41
10%
-35
- C2 -
3U61
4
DPA44_BPT4
B:
[38-321]
----------------------------------
F
K
S
I
T
S
K
G
K
I
P
H
I
I
L
H
S
P
S
P
G
T
G
K
T
T
V
A
K
A
L
C
H
D
----------------
V
N
-----------------------------------------------------------
A
D
M
M
F
V
N
G
S
------
D
-----
C
---
K
---
I
D
F
V
R
G
-
P
L
T
N
F
A
S
A
------
A
S
F
---------------
D
G
-
R
Q
-
K
V
I
V
I
D
E
F
D
R
S
G
L
-------
A
E
S
Q
R
H
L
R
S
F
M
E
A
-
Y
S
S
-
N
C
S
I
I
I
T
A
N
--
N
------
I
D
G
I
I
K
P
L
Q
S
R
C
R
---
V
I
T
F
G
Q
P
T
D
--
E
D
K
I
E
M
M
K
Q
M
I
R
R
L
T
E
I
C
K
-----
H
-------
E
G
I
A
I
A
-
D
M
K
V
V
A
A
L
V
K
K
N
F
P
D
F
R
K
T
I
G
E
L
D
S
Y
S
S
K
G
V
------------
L
D
A
----------------
I
D
D
V
L
E
S
L
K
N
----
K
D
V
K
Q
L
R
A
L
A
P
-
K
Y
A
------
A
D
Y
S
W
F
V
G
K
L
A
E
E
------------------------------------
I
Y
S
R
V
T
P
Q
S
I
I
R
M
Y
E
I
V
G
E
N
N
Q
Y
H
G
I
-
A
A
--
N
T
E
L
H
L
A
Y
L
F
I
Q
L
A
C
E
M
--------
23
HHSearch
38.05
10%
-68
- C2 -
3BOS
13
?
A:
[50-240]
------------------------------------------
D
G
V
Q
A
I
Y
L
W
G
P
V
K
S
G
R
T
H
L
I
H
A
A
C
A
R
----------------
A
N
E
L
---------------------------------------
E
-----------------
R
R
S
F
Y
I
P
L
G
------
I
-------------
H
----
A
-
S
I
S
T
A
L
L
--------
E
G
---------------
L
E
-
Q
F
-
D
L
I
C
I
D
D
V
D
A
V
A
G
H
P
------
L
W
E
E
A
I
F
D
L
Y
N
R
V
A
E
Q
K
R
G
S
L
I
V
S
A
S
A
-
S
P
M
E
---
A
G
F
V
L
P
D
L
V
S
R
M
H
W
G
L
T
Y
Q
L
Q
P
M
M
D
--
D
E
K
L
A
A
L
Q
R
R
-------
A
A
-----
M
-------
R
G
L
Q
L
P
-
E
-
D
V
G
R
F
L
L
N
R
M
A
R
D
L
R
T
L
F
D
V
L
D
R
L
D
K
A
S
M
V
H
--
Q
----
R
K
L
T
I
P
F
V
K
E
M
L
------------------------------------------------------------------------------------------------------------------------------------------------------