@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu26740: (2016-07-11 )
MSSKEKKSVTILTESQLSSRAFKDEAYEFYKELRKSQALYPLSLGALGKGWLISRYDDAIHLLKNEKLKKNYENVFTAKEKRPALLKNEETLTKHMLNSDPPDHNRLRTLVQKAFTHRMILQLEDKIQHIADSLLDKVQPNKFMNLVDDYAFPLPIIVISEMLGIPLEDRQKFRVWSQAIIDFSDAPERLQENDHLLGEFVEYLESLVRKKRREPAGDLISALIQAESEGTQLSTEELYSMIMLLIVAGHETTVNLITNMTYALMCHHDQLEKLRQQPDLMNSAIEEALRFHSPVELTTIRWTAEPFILHGQEIKRKDVIIISLASANRDEKIFPNADIFDIERKNNRHIAFGHGNHFCLGAQLARLEAKIAISTLLRRCPNIQLKGEKKQMKWKGNFLMRALEELPISF
Atome Classification :
(64 SA)
.........10........20........30........40....-....-50........60.......----.70....---....80.--.......90...--.....100.......110.......120.......130.....-.--.140..-......150.......160.......170.......180---....-....--190-........200.......210.......220....-...-230.......240.......250.......260.......270.......280.......290....--...-300.........310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSKEK
K
S
V
T
I
L
T
E
S
QLSSRA
F
K
D
E
A
Y
E
F
Y
K
E
L
R
KSQAL
Y
P
L
SLG-ALGK-G
W
L
I
SRY
D
D
A
I
H
L
L
K
N
E
K
L
----
K
K
N
Y
E
N
V
---
F
TAKEKR--
P
A
LLK
N
E
E
T
L
T
K
--
H
M
LNSDPP
D
H
N
R
L
R
T
L
V
Q
K
A
F
T
H
R
M
I
L
Q
L
E
D
K
I
Q
H
I
A
D
S
L
L
D
K-V--Q
P
-
N
K
F
-
M
N
L
V
D
DYAFP
L
P
I
I
V
I
S
E
M
LGIP
L
E
D
R
Q
K
F
R
V
W
S
Q
A
I
I----DFSD-A
P
E
R
--
L
Q
--EN
D
H
L
L
G
E
F
V
E
Y
L
E
S
L
V
R
K
KRREP
A
G
D
L
I
S
A
L
I
QA-ESE-GTQL
S
T
E
E
L
Y
S
M
I
M
L
L
I
VAGH
E
T
T
V
N
L
I
TN
M
T
Y
A
L
M
CH
H
D
Q
L
E
K
L
R
QQP
D
L
M
N
S
A
I
E
E
A
L
RFHSPV
E
--
L
T
T
-
I
--
R
WTAE
P
F
I
LHGQEIKRK
D
V
I
I
I
S
LASANRDEKIFPNA
D
I
F
D
I
ERKNN
R
H
I
A
FGHGN
H
F
C
L
G
A
Q
L
A
R
L
E
A
K
I
A
I
S
T
L
L
R
RCPN
I
Q
LKGEKK
Q
M
K
WK
G
N
F
L
M
R
A
L
E
ELPISF
10
PsiBlast_PDB
83.59
41%
-12
- C4 -
2BVJ
3
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
D
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
38
PsiBlast_CBE
83.15
41%
-13
- C4 -
4BF4
3
PIKC_STRVZ
B:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
23
PsiBlast_CBE
83.11
41%
-12
- C4 -
4UMZ
2
PIKC_STRVZ
B:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
6
PsiBlast_PDB
83.01
41%
-12
- C4 -
3ZK5
2
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
22
PsiBlast_CBE
82.96
41%
-14
- C4 -
2WHW
4
PIKC_STRVZ
B:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
40
PsiBlast_CBE
82.92
41%
-11
- C4 -
3ZPI
6
PIKC_STRVZ
B:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
2
PsiBlast_PDB
82.80
41%
-14
- C4 -
2WI9
2
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
9
PsiBlast_PDB
82.73
41%
-15
- C4 -
4UMZ
2
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
39
PsiBlast_CBE
82.68
41%
-14
- C4 -
4B7S
6
PIKC_STRVZ
B:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
32
PsiBlast_CBE
82.67
41%
-15
- C4 -
4BF4
1
PIKC_STRVZ
H:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
LA
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
1
PsiBlast_PDB
82.66
41%
-13
- C4 -
2WHW
2
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
33
PsiBlast_CBE
82.64
41%
-18
- C4 -
4BF4
17
PIKC_STRVZ
G:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
LA
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
15
PsiBlast_PDB
82.64
41%
-14
- C4 -
4B7D
3
PIKC_STRVZ
A:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
D
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
37
PsiBlast_CBE
82.63
41%
-14
- C4 -
4BF4
2
PIKC_STRVZ
C:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
LA
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
25
PsiBlast_CBE
82.62
41%
-18
- C4 -
4BF4
17
PIKC_STRVZ
O:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
LA
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W
21
PsiBlast_CBE
82.61
41%
-17
- C4 -
2WI9
5
PIKC_STRVZ
B:
[44-425]
---------------------
F
A
A
D
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
T
P
-
E
G
N
E
-
V
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
F
----
S
K
D
W
R
N
S
---
T
T
P
--------
L
T
E
A
E
A
A
L
N
H
--
N
M
L
E
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
I
V
D
G
L
V
D
A
-
M
L
A
A
P
-
D
G
R
-
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
P
D
R
A
A
F
R
V
W
T
D
A
F
V
-----
F
P
D
-
D
P
A
Q
--
A
Q
--
T
A
---
M
A
E
M
S
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
G
E
D
L
L
S
A
L
V
R
T
-
S
D
E
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
L
D
G
A
V
E
E
M
L
R
Y
E
G
P
V
E
--
S
A
T
-
Y
--
R
F
P
V
E
P
V
D
L
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
D
T
A
G
H
L
A
F
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
W