@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu26800: (2016-07-11 )
MNEFMKKFSLTKPIIQAPMAGGITKPRLASAVSNQGALGSLASGYLTPDLLEQQIKEIFELTDAPFQINVFVPLGLEMPPKDQIKKWKENIPLANQVNQFTSVQEEWDDFYQKIDLILKYKVKACSFTFDLPPEDAVKELKTAGCCLIGTASTVEEALLMEERGMDIVVLQGSEAGGHRGAFLPSKGESAVGLMALIPQAADALSVPVIAAGGMIDHRGVKAALTLGAQGVQIGSAFLICHESNAHPVHKQKILEANEADTKLTTLFSGKEARGIVNKWMEENEQFETQTLPYPYQNTLTKAMRQKASLQNNHDQMSLWAGQGIRSLTEEISVKQLLNQLCQEDIKI
Atome Classification :
(20 SA)
--.........10........20........30........40.....-.---..50........60........70........80.....--...90-..--......100...---.--...110.---......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......-----280.......-290-.-.-.--.--....300..--.......310.......320......-.330.......340.....----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--
M
N
E
F
M
K
K
FSLT
K
P
I
I
QAPMAGGIT
K
P
R
L
A
S
A
VSNQGA
L
G
S
L
A
SGYL-
T
---
P
D
L
L
E
Q
Q
I
K
E
I
F
E
LTDA
P
F
Q
I
N
V
F
V
PLGLEMP
P
K
D
Q
I
K
K
--
W
K
ENI-PL--
A
N
Q
V
N
Q
F
T
S
V
Q
E
---
E
--
W
D
D
F
Y
Q
K
---
I
D
L
I
L
K
Y
K
V
K
A
C
S
F
T
FDLP
P
E
D
A
V
K
E
L
K
TAG
C
C
L
IG
T
A
S
T
V
E
E
A
L
L
M
E
ERG
M
D
I
V
V
L
QGSEAGGHRGAFLPSKGESA
V
G
L
M
A
LIPQAADALSV
P
V
I
AAGGMIDHRG
V
K
A
A
L
TLGAQ
G
V
Q
I
G
S
A
F
L
I
C
HESNAHP
V
H
K
Q
K
I
LEANEAD
T
K
L
T
T
L
FSG
K
E
A
R
G
I
V
N
K
W
-----
M
E
ENEQFETQ-TL--P-Y-
P
--
Y
--
Q
N
T
L
T
--
K
A
--
M
R
Q
K
ASLQNNH
D
Q
M
S
L
W
A
G
Q
G
I
R
S
L
T
-
E
E
I
S
V
K
Q
L
L
N
Q
L
C
Q
E
DIKI----------
35
HHSearch
78.01
31%
-99
- C2 -
3BO9
13
?
A:
[16-315]
--
R
T
R
V
T
D
L
L
E
I
E
H
P
I
L
M
G
G
M
A
-
W
A
G
T
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
G
S
G
A
M
-
K
---
P
D
D
L
R
K
A
I
S
E
L
R
Q
K
T
D
K
P
F
G
V
N
I
I
L
V
S
P
W
-------------------------------------------
A
D
D
L
---
V
K
V
C
I
E
E
K
V
P
V
V
T
F
G
A
G
N
P
-
T
K
Y
I
R
E
L
K
E
N
G
T
K
V
I
P
V
V
A
S
D
S
L
A
R
M
V
E
R
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
H
I
G
E
---------
V
T
T
F
V
L
V
N
K
V
S
R
S
V
N
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
I
V
K
A
S
I
R
D
T
V
V
T
G
A
K
L
G
H
P
A
R
V
L
R
T
P
F
-----
A
R
K
I
Q
E
M
E
F
E
-
N
P
--
M
---
Q
--
A
--
E
E
M
L
V
--
G
S
--
L
R
R
A
V
V
-
E
G
D
L
E
R
G
S
F
M
V
G
Q
S
A
G
L
I
D
-
E
I
K
P
V
K
Q
I
I
E
D
I
L
K
E
F
K
E
-----------
3
PsiBlast_PDB
76.65
36%
-0
- C2 -
4QIT
2
?
A:
[9-354]
---
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
-
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
-
A
---
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
-
R
A
--
W
L
D
Y
L
K
P
L
--
F
A
E
F
G
A
E
P
P
V
R
L
---
K
NI
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
S
R
G
V
F
E
P
E
R
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
-----
F
F
D
A
A
A
P
G
V
P
-
P
L
--
P
D
Y
-
P
--
F
--
V
Y
D
A
T
--
K
A
--
L
Q
T
A
A
L
A
R
G
N
H
D
-
F
A
A
Q
W
A
G
Q
G
A
A
L
A
-
R
E
L
P
A
A
E
L
L
R
T
L
V
E
E
--------------
24
PsiBlast_CBE
76.17
36%
3
- C2 -
4QIU
2
?
B:
[8-353]
---
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
-
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
-
A
---
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
-
R
A
--
W
L
D
Y
L
K
P
L
--
F
A
E
F
G
A
E
P
P
V
R
L
---
K
NI
Y
L
S
F
L
E
D
PTL
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
C
R
G
V
F
E
P
E
R
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
-----
F
F
D
A
A
A
P
G
V
P
-
P
L
--
P
D
Y
-
P
--
F
--
V
Y
D
A
T
--
K
A
--
L
Q
T
A
A
L
A
R
G
N
H
D
-
F
A
A
Q
W
A
G
Q
G
A
A
L
A
-
R
E
L
P
A
A
E
L
L
R
T
L
V
E
E
--------------
23
PsiBlast_CBE
75.95
36%
5
- C2 -
4QIT
2
?
B:
[9-354]
---
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
-
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
-
A
---
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
-
R
A
--
W
L
D
Y
L
K
P
L
--
F
A
E
F
G
A
E
P
P
V
R
L
---
K
NI
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
S
R
G
V
F
E
P
E
R
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
-----
F
F
D
A
A
A
P
G
V
P
-
P
L
--
P
D
Y
-
P
--
F
--
V
Y
D
A
T
--
K
A
--
L
Q
T
A
A
L
A
R
G
N
H
D
-
F
A
A
Q
W
A
G
Q
G
A
A
L
A
-
R
E
L
P
A
A
E
L
L
R
T
L
V
E
E
--------------
4
PsiBlast_PDB
75.56
36%
3
- C2 -
4QIU
2
?
A:
[8-353]
---
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
-
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
-
A
---
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
-
R
A
--
W
L
D
Y
L
K
P
L
--
F
A
E
F
G
A
E
P
P
V
R
L
---
K
NI
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
C
R
G
V
F
E
P
E
R
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
-----
F
F
D
A
A
A
P
G
V
P
-
P
L
--
P
D
Y
-
P
--
F
--
V
Y
D
A
T
--
K
A
--
L
Q
T
A
A
L
A
R
G
N
H
D
-
F
A
A
Q
W
A
G
Q
G
A
A
L
A
-
R
E
L
P
A
A
E
L
L
R
T
L
V
E
E
--------------
22
PsiBlast_CBE
75.44
36%
5
- C2 -
4Q4K
1
?
B:
[3-348]
---
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
-
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
-
A
---
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
-
R
A
--
W
L
D
Y
L
K
P
L
--
F
A
E
F
G
A
E
P
P
V
R
L
---
K
NI
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
V
F
E
P
E
R
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
-----
F
F
D
A
A
A
P
G
V
P
-
P
L
--
P
D
Y
-
P
--
F
--
V
Y
D
A
T
--
K
A
--
L
Q
T
A
A
L
A
R
G
N
H
D
-
F
A
A
Q
W
A
G
Q
G
A
A
L
A
-
R
E
L
P
A
A
E
L
L
R
T
L
V
E
E
--------------
21
PsiBlast_CBE
75.40
36%
3
- C2 -
4QIS
1
?
B:
[8-353]
---
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
-
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
-
A
---
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
-
R
A
--
W
L
D
Y
L
K
P
L
--
F
A
E
F
G
A
E
P
P
V
R
L
---
K
NI
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
V
F
E
P
E
R
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
-----
F
F
D
A
A
A
P
G
V
P
-
P
L
--
P
D
Y
-
P
--
F
--
V
Y
D
A
T
--
K
A
--
L
Q
T
A
A
L
A
R
G
N
H
D
-
F
A
A
Q
W
A
G
Q
G
A
A
L
A
-
R
E
L
P
A
A
E
L
L
R
T
L
V
E
E
--------------
31
HHSearch
75.00
37%
-1
- C2 -
4QIT
2
?
A:
[9-356]
---
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
-
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
-
A
---
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
--
L
D
Y
L
K
-
P
L
F
A
E
F
G
A
E
P
P
V
R
L
K
N
IYL
S
--
F
L
E
D
P
T
L
---
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
S
R
G
V
F
E
P
E
R
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
-----
F
F
D
A
A
A
P
G
V
P
-
P
L
--
P
-
D
Y
P
--
F
--
V
Y
D
A
T
--
K
A
--
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
A
R
-
E
L
-
P
A
A
E
L
L
R
T
L
V
E
E
L
R
------------
2
PsiBlast_PDB
73.58
36%
4
- C2 -
4Q4K
1
?
A:
[3-348]
---
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
-
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
-
A
---
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
-
R
A
--
W
L
D
Y
L
K
P
L
--
F
A
E
F
G
A
E
P
P
V
R
L
---
K
NI
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
V
F
E
P
E
R
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
-----
F
F
D
A
A
A
P
G
V
P
-
P
L
--
P
D
Y
-
P
--
F
--
V
Y
D
A
T
--
K
A
--
L
Q
T
A
A
L
A
R
G
N
H
D
-
F
A
A
Q
W
A
G
Q
G
A
A
L
A
-
R
E
L
P
A
A
E
L
L
R
T
L
V
E
E
--------------
32
HHSearch
73.48
32%
-84
* C2 *
2Z6I
5
?
A:
[2-308]
--
K
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
-
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
G
G
N
A
-
P
---
K
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
L
S
P
F
-------------------------------------------
V
E
D
I
---
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
-
S
K
Y
M
E
R
F
H
E
A
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
K
---------
L
T
T
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
S
A
Q
H
F
G
H
A
V
R
A
I
K
N
Q
L
-----
T
R
D
F
E
L
A
E
K
D
-
A
F
K
Q--
D
-
L
E
I
F
--
E
Q
M
G
A
--
G
A
--
L
A
K
A
V
V
-
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
-
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
-----------
1
PsiBlast_PDB
73.24
36%
6
- C2 -
4QIS
1
?
A:
[9-353]
----
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
-
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
-
A
---
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
-
R
A
--
W
L
D
Y
L
K
P
L
--
F
A
E
F
G
A
E
P
P
V
R
L
---
K
NI
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
V
F
E
P
E
R
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
-----
F
F
D
A
A
A
P
G
V
P
-
P
L
--
P
D
Y
-
P
--
F
--
V
Y
D
A
T
--
K
A
--
L
Q
T
A
A
L
A
R
G
N
H
D
-
F
A
A
Q
W
A
G
Q
G
A
A
L
A
-
R
E
L
P
A
A
E
L
L
R
T
L
V
E
E
--------------
6
PsiBlast_PDB
71.50
28%
-98
- C2 -
3BO9
13
?
A:
[40-312]
---------------------------
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
G
S
G
A
M
-
K
---
P
D
D
L
R
K
A
I
S
E
L
R
Q
K
T
D
K
P
F
G
V
N
I
I
L
-----------
V
S
P
--
W
A
D
D
L
---------------------------------
V
K
V
C
I
E
E
K
V
P
V
V
T
F
G
A
G
N
P
T
K
-
Y
I
R
E
L
K
E
N
G
T
K
V
I
P
V
V
A
S
D
S
L
A
R
M
V
E
R
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
H
I
G
---------
E
V
T
T
F
V
L
V
N
K
V
S
R
S
V
N
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
I
V
K
A
S
I
R
D
T
V
V
T
G
A
K
L
G
H
P
A
R
V
L
R
T
P
F
-----
A
R
K
I
Q
E
M
E
F
E
-
N
---
P
-
M
-
Q
--
A
--
E
E
M
L
V
--
G
S
--
L
R
-
R
A
V
V
E
G
D
L
E
R
G
S
F
M
V
G
Q
S
A
G
L
I
D
-
E
I
K
P
V
K
Q
I
I
E
D
I
L
K
E
--------------
33
HHSearch
71.20
30%
-74
- C2 -
4IQL
7
?
A:
[21-324]
--
M
N
R
I
C
E
L
L
G
I
E
H
P
I
I
S
G
G
M
V
-
W
C
S
G
W
K
L
A
S
A
V
S
N
C
G
G
L
G
L
I
G
A
G
S
M
-
H
---
P
D
N
L
E
H
H
I
R
S
C
K
A
A
T
D
K
P
F
G
V
N
V
P
L
L
Y
P
E
-------------------------------------------
M
D
K
I
---
M
E
I
I
M
R
E
H
V
P
V
V
V
T
S
A
G
S
P
-
K
V
W
T
A
K
L
K
A
A
G
S
K
V
I
H
V
V
S
S
A
T
F
A
R
K
S
E
A
A
G
V
D
A
I
V
A
E
G
F
E
A
G
G
H
N
G
R
E
-------
E
T
T
T
L
C
L
I
P
E
V
V
D
A
V
N
I
P
V
V
A
A
G
G
I
A
S
G
R
A
V
A
A
A
L
A
L
G
A
D
A
V
Q
V
G
T
R
F
A
L
S
E
E
S
S
A
H
E
D
F
K
A
H
C
R
R
S
V
E
G
D
T
M
L
S
L
K
A
-
V
S
P
T
R
L
L
K
N
K
F
-----
Y
Q
D
V
F
A
A
E
Q
R
-
G
A
--
S
-
V
-
E
--
E
--
L
R
E
L
L
--
G
R
G
R
A
K
Q
G
I
F
-
E
G
D
L
H
E
G
E
L
E
I
G
Q
A
V
S
Q
I
S
-
H
A
E
T
V
A
E
I
M
V
D
L
V
D
G
Y
K
R
-----------
9
PsiBlast_PDB
66.95
28%
-76
- C2 -
2Z6I
5
?
A:
[5-302]
--
I
T
E
L
L
K
---
I
D
Y
P
I
F
Q
G
G
M
A
W
-
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
G
G
N
A
-
P
---
K
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
-----
L
S
P
--------
F
V
E
D
I
---------------------------------
V
D
L
V
I
E
E
G
V
K
V
V
T
-
T
G
A
G
N
P
S
K
Y
M
E
R
F
H
E
A
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
K
L
T
T
---------
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
S
A
Q
H
F
G
H
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
K
D
A
F
K
Q
------
D
-
L
-
E
--
I
--
F
E
Q
M
G
--
A
G
--
A
L
A
K
A
V
V
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
-
K
E
E
T
A
E
E
I
L
K
D
L
-----------------
5
PsiBlast_PDB
63.16
29%
-73
- C2 -
2Z6J
5
?
A:
[14-302]
--------------
P
I
F
Q
G
G
M
A
W
-
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
G
G
N
A
-
P
---
K
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
-----------
L
S
P
--
F
V
E
D
I
---------------------------------
V
D
L
V
I
E
E
G
V
K
V
V
T
-
T
G
A
G
N
P
S
K
Y
M
E
R
F
H
E
A
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
K
L
T
T
---------
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
S
A
Q
---
H
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
K
D
A
F
-------------------
E
Q
M
G
--
A
G
--
A
L
A
K
A
V
V
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
-
K
E
E
T
A
E
E
I
L
K
D
L
-----------------
25
PsiBlast_CBE
62.82
32%
-52
- C2 -
4IQL
6
?
B:
[21-242]
--
M
N
R
I
C
E
L
L
G
I
E
H
P
I
I
S
G
G
M
V
W
-
C
S
G
W
K
L
A
S
A
V
S
N
C
G
G
L
G
L
I
G
A
G
S
M
-
H
---
P
D
N
L
E
H
H
I
R
S
C
K
A
A
T
D
K
P
F
G
V
N
V
--
P
L
--
L
Y
P
E
M
D
K
I
M
E
II
M
R
E
H
V
-
P
V
--
V
----------------------------------------
V
T
S
A
G
S
P
K
V
W
T
A
K
L
K
A
A
G
S
K
V
I
H
V
V
S
S
A
T
F
A
R
K
S
E
A
A
G
V
D
A
I
V
A
E
G
F
E
A
G
G
H
-------
N
G
R
E
E
T
T
T
L
C
L
I
P
E
V
V
D
A
V
N
I
P
V
V
A
A
G
G
I
A
S
G
R
A
V
A
A
A
L
A
L
G
A
D
A
V
Q
V
G
T
R
F
A
L
S
E
E
S
S
A
H
E
D
F
K
A
H
C
R
R
S
V
E
G
D
T
M
L
S
----------------------------------------------------------------------------------------------------------------
55
Fugue
61.97
27%
2
- C2 -
2GJL
1
2NPD_PSEAE
A:
[3-326]
VF
R
T
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
-
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
Q
P
S
---
P
E
A
L
A
A
E
I
A
R
C
R
E
L
T
D
R
P
F
G
V
N
L
T
L
L
P
T
Q
K
P
V
P
---------------------------------------
Y
A
E
Y
---
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
N
-
D
P
G
E
H
I
A
E
F
R
R
H
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
-------
E
D
D
I
P
G
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
I
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
-----
S
Q
E
V
L
A
I
E
A
R
-
G
G
--
A
-
G
-
Y
--
A
DI
A
A
L
V
S
--
G
Q
--
R
G
R
Q
V
Y
Q
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
-
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
RQR
L
E
G
M
L
A
10
PsiBlast_PDB
61.74
32%
-52
- C2 -
4IQL
7
?
A:
[21-242]
--
M
N
R
I
C
E
L
L
G
I
E
H
P
I
I
S
G
G
M
V
W
-
C
S
G
W
K
L
A
S
A
V
S
N
C
G
G
L
G
L
I
G
A
G
S
M
-
H
---
P
D
N
L
E
H
H
I
R
S
C
K
A
A
T
D
K
P
F
G
V
N
V
--
P
L
--
L
Y
P
E
M
D
K
I
M
E
I
I
M
R
E
H
V
-
P
V
--
V
----------------------------------------
V
T
S
A
G
S
P
K
V
W
T
A
K
L
K
A
A
G
S
K
V
I
H
V
V
S
S
A
T
F
A
R
K
S
E
A
A
G
V
D
A
I
V
A
E
G
F
E
A
G
G
H
-------
N
G
R
E
E
T
T
T
L
C
L
I
P
E
V
V
D
A
V
N
I
P
V
V
A
A
G
G
I
A
S
G
R
A
V
A
A
A
L
A
L
G
A
D
A
V
Q
V
G
T
R
F
A
L
S
E
E
S
S
A
H
E
D
F
K
A
H
C
R
R
S
V
E
G
D
T
M
L
S
----------------------------------------------------------------------------------------------------------------
34
HHSearch
61.15
29%
-26
- C2 -
2GJL
1
2NPD_PSEAE
A:
[5-315]
--
R
T
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
-
W
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
Q
P
S
---
P
E
A
L
A
A
E
I
A
R
C
R
E
L
T
D
R
P
F
G
V
N
L
T
L
L
P
T
Q
K
P
---------------------------------------
V
P
Y
A
E
Y
---
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
N
D
P
-
G
E
H
I
A
E
F
R
R
H
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
E
D
-------
D
I
P
G
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
I
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
-----
S
Q
E
V
L
A
I
E
A
R
G
G
A
--
G
-
Y
-
A
--
D
--
I
A
A
L
V
S
G
Q
R
--
G
R
Q
V
Y
Q
-
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
-
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
-----------
8
PsiBlast_PDB
60.60
27%
-8
- C2 -
2GJN
2
2NPD_PSEAE
A:
[6-312]
---
T
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
-
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
--
L
-
T
QPS
P
E
A
L
A
A
E
I
A
R
C
R
E
L
T
D
R
P
F
G
V
N
------
L
T
L
L
P
T
Q
K
P
V
P
--
Y
A
E
-----------------------------
Y
R
A
---
A
--
I
I
E
A
G
I
R
V
V
E
T
A
G
N
D
P
G
E
H
-
I
A
E
F
R
R
H
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
-------
P
G
E
D
D
I
P
G
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
I
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
-----
S
Q
E
V
L
A
I
E
A
R
G
G
A
--
G
-
Y
-
A
--
D
--
I
A
A
L
V
--
S
G
--
Q
R
G
R
Q
V
Y
Q
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
--------------