@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu27160: (2016-07-12 )
MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRFDFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAHRILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGFNYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLVDRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLLSFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAFSLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHAYKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKITVKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQGRQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGVSYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRFWKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAASTRSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAHLPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQVLAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKASAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAPFRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRVENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQEESAVWLQKLQDQRRYVKDVWTGM
Atome Classification :
(83 SA)
-.........10........20......--..30........40........50........60...-.....70........80...----------.....90........100.......110...-....120.......130.......-140....-...150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330-.......340.......350.......360.......370.......380...--....390.......400.......410.......420.......430.......440.-----......450....--...460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MKQASAIPQPKTYGPLKNLPHL
E
K
E
Q
L
--
S
Q
S
L
W
R
I
A
D
ELG
P
I
F
R
FDFPGV
S
S
V
F
VSG
H
N
L
V
A
E
V
C
-
D
E
K
R
F
D
K
N
L
G
K
G
L
Q
K
V
R
E
FG----------GDG
L
F
TSWTHEP
N
W
Q
K
A
H
R
ILLPSF
S
Q
K
A
M
K
-
G
Y
H
S
M
M
L
D
I
A
T
Q
L
I
Q
K
W
SRLNPNE-EIDVA
D
D
-
M
T
R
L
T
L
D
T
IGLCGFNYRF
N
S
FYRDSQH
P
F
I
T
S
M
L
R
A
L
K
E
A
M
N
Q
S
K
RLGL
Q
D
K
M
M
V
K
T
K
L
Q
F
Q
K
D
I
E
V
M
N
S
L
V
D
R
M
I
A
E
RKANP
D
E
N
I
K
D
L
L
S
L
M
L
YAKDPVTGETLDDEN
I
R
Y
Q
I
I
T
F
L
IAGHET
T
S
G
L
L
S
F
A
I
Y
C
LLT
H
P
E
K
L
K
K
A
Q
E
E
A
D
R
VLTDD
T
P
E
Y
K
Q
I
Q
Q
L
K
Y
I
R
M
V
L
NET
L
R
LYPTAP-
A
F
S
L
Y
AKEDTVLGGEYPISKG
Q
P
V
T
V
L
I
PKLHRDQNAWGP
D
A
EDFRPERFEDP--SSIPHHAYKPFGNGQ
R
A
C
I
G
M
Q
F
A
L
Q
E
A
T
M
V
L
G
L
V
L
K
H
F
E
L
I
NHTG
Y
E
L
K
I
K
E
A
L
T
IK-----PD
D
F
K
I
T
V
KPR
K
T
--
A
A
I
N
V
Q
RKEQADIKAETKPKETKPKHG
T
P
L
L
V
L
FGSNLGTAE
G
I
A
G
E
L
A
AQGRQMGFTAETA
P
L
D
D
Y
I
GKLPEEG
A
V
V
I
V
TASYNGAPPD
N
A
A
G
F
V
E
W
L
K
E
L
EEGQLKG
V
S
Y
A
V
F
GCGN
R
S
W
A
S
T
Y
Q
R
I
P
R
L
I
D
D
M
M
K
AKGAS
R
L
T
AIGEGDAA
D
D
F
E
S
H
R
E
S
W
E
N
R
F
W
K
E
T
M
D
AF
D
I
N
E
I
A
Q
KEDRPS
L
S
I
T
F
LSEATET
P
V
A
K
A
Y
GAFE
G
I
V
LENRELQTAASTRS
T
R
H
I
E
L
EIPAGKTYKEGD
H
I
G
I
LPK
N
S
R
E
L
V
Q
R
V
L
S
RFGLQSN
H
V
I
K
VSGSA
H
M
AHLPMDR
P
I
K
V
V
D
L
L
S
S
Y
V
E
L
Q
E
P
A
S
R
L
Q
L
R
E
L
ASYTVCPP
H
Q
K
E
L
E
Q
L
VSDDG
I
Y
K
E
Q
V
L
A
K
R
L
T
M
L
D
F
L
E
DYPACE
M
P
F
E
R
F
L
A
L
LPSLK
P
R
Y
Y
SISSSP
K
V
H
A
N
I
V
S
M
T
V
G
V
V
K
ASAWSGRGEYR
G
V
A
S
N
Y
L
A
ELNTGD
A
A
A
C
F
I
RTPQSGFQMPNDPET
P
M
I
M
VGPGTG
I
A
P
F
R
G
F
I
Q
A
R
S
V
L
K
KEG
S
T
L
G
E
A
L
L
Y
FGCRRP
D
H
D
D
L
Y
R
E
E
L
D
Q
A
EQD
G
L
V
T
I
R
R
C
Y
S
R
VENE
P
K
G
Y
V
Q
H
L
L
K
Q
D
T
Q
K
L
M
T
L
I
EKG
A
H
I
Y
V
CGDGSQMAP
D
V
E
R
T
L
R
L
A
Y
E
A
E
K
AAS
Q
E
E
S
A
V
W
L
Q
K
L
Q
D
Q
R
R
Y
V
K
D
V
WTGM
76
PsiBlast_CBE
91.58
67%
-100
- C3 -
3KX5
1
CPXB_BACME
B:
[5-452]
-------
M
P
Q
P
K
T
F
G
E
L
K
N
L
P
L
L
N
T
D
K
P
--
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
-
D
E
S
R
F
D
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
----------
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
-
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
-
H
I
E
V
P
E
D
-
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
-
G
E
Q
S
D
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
E
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
--
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
-----
P
E
G
F
V
V
K
A
K
S
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
91.56
67%
-102
- C3 -
3WSP
3
CPXB_BACME
A:
[6-453]
-------
M
P
Q
P
K
T
F
G
E
L
K
N
L
P
L
L
N
T
D
K
P
--
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
-
D
E
S
R
F
D
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
----------
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
-
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
-
H
I
E
V
P
E
D
-
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
-
D
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
--
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
-----
P
E
G
F
V
V
K
A
K
S
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
91.19
67%
-102
- C3 -
1P0W
1
CPXB_BACME
B:
[5-452]
-------
M
P
Q
P
K
T
F
G
E
L
K
N
L
P
L
L
N
T
D
K
P
--
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
-
D
E
S
R
F
D
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
----------
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
-
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
-
H
I
E
V
P
E
D
-
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
-----
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
-
D
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
--
S
A
I
P
Q
H
A
F
K
P
W
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
-----
P
E
G
F
V
V
K
A
K
S
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
91.18
67%
-97
- C3 -
4HGJ
3
CPXB_BACME
B:
[5-452]
-------
M
P
Q
P
K
T
F
G
E
L
K
N
L
P
L
L
N
T
D
K
P
--
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
-
D
E
S
R
F
D
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
----------
G
D
G
L
A
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
-
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
-
H
I
E
V
P
E
D
-
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
-
D
D
L
L
A
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
--
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
-----
P
E
G
F
V
V
K
A
K
S
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
90.98
67%
-98
- C3 -
1JPZ
2
CPXB_BACME
A:
[8-455]
-------
M
P
Q
P
K
T
F
G
E
L
K
N
L
P
L
L
N
T
D
K
P
--
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
-
D
E
S
R
F
D
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
----------
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
-
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
-
H
I
E
V
P
E
D
-
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
---
Q
S
D
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
--
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
-----
P
E
G
F
V
V
K
A
K
S
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
90.92
67%
-103
- C3 -
2HPD
1
CPXB_BACME
B:
[5-452]
-------
M
P
Q
P
K
T
F
G
E
L
K
N
L
P
L
L
N
T
D
K
P
--
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
-
D
E
S
R
F
D
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
----------
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
-
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
-
H
I
E
V
P
E
D
-
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
-
G
E
Q
S
D
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
--
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
-----
P
E
G
F
V
V
K
A
K
S
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
90.87
67%
-103
- C3 -
2J4S
5
CPXB_BACME
B:
[5-452]
-------
M
P
Q
P
K
T
F
G
E
L
K
N
L
P
L
L
N
T
D
K
P
--
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
-
D
E
S
R
F
D
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
----------
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
-
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
-
H
I
E
V
P
E
D
-
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
-
D
D
L
L
T
H
M
L
N
G
K
D
P
-----
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
--
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
-----
P
E
G
F
V
V
K
A
K
S
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
90.82
67%
-98
- C3 -
4HGH
3
CPXB_BACME
B:
[5-452]
-------
M
P
Q
P
K
T
F
G
E
L
K
N
L
P
L
L
N
T
D
K
P
--
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
-
D
E
S
R
F
D
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
----------
G
D
G
L
A
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
-
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
-
H
I
E
V
P
E
D
-
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
-
D
D
L
L
A
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
--
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
-----
P
E
G
F
V
V
K
A
K
S
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
90.77
67%
-99
- C3 -
1ZOA
6
CPXB_BACME
B:
[8-455]
-------
M
P
Q
P
K
T
F
G
E
L
K
N
L
P
L
L
N
T
D
K
P
--
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
-
D
E
S
R
F
D
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
----------
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
-
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
-
H
I
E
V
P
E
D
-
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
-
G
E
Q
S
D
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
V
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
--
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
-----
P
E
G
F
V
V
K
A
K
S
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
90.77
67%
-100
- C3 -
2J4S
3
CPXB_BACME
A:
[5-452]
-------
M
P
Q
P
K
T
F
G
E
L
K
N
L
P
L
L
N
T
D
K
P
--
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
-
D
E
S
R
F
D
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
----------
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
-
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
-
H
I
E
V
P
E
D
-
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
-
D
D
L
L
T
H
M
L
N
G
K
D
---
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
--
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
-----
P
E
G
F
V
V
K
A
K
S
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
90.76
67%
-98
- C3 -
1BU7
7
CPXB_BACME
A:
[5-452]
-------
M
P
Q
P
K
T
F
G
E
L
K
N
L
P
L
L
N
T
D
K
P
--
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
-
D
E
S
R
F
D
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
----------
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
-
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
-
H
I
E
V
P
E
D
-
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
-
D
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
--
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
-----
P
E
G
F
V
V
K
A
K
S
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
90.73
67%
-104
- C3 -
1P0X
1
CPXB_BACME
B:
[5-452]
-------
M
P
Q
P
K
T
F
G
E
L
K
N
L
P
L
L
N
T
D
K
P
--
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
-
D
E
S
R
F
D
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
----------
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
-
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
-
H
I
E
V
P
E
D
-
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
-----
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
G
E
Q
S
-
D
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
--
S
A
I
P
Q
H
A
F
K
P
Y
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
-----
P
E
G
F
V
V
K
A
K
S
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
90.64
67%
-103
- C3 -
1ZO4
11
CPXB_BACME
B:
[8-455]
-------
M
P
Q
P
K
T
F
G
E
L
K
N
L
P
L
L
N
T
D
K
P
--
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
-
D
E
S
R
F
D
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
----------
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
-
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
-
H
I
E
V
P
E
D
-
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
-
G
E
Q
S
D
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
S
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
--
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
-----
P
E
G
F
V
V
K
A
K
S
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
90.62
67%
-102
- C3 -
2HPD
1
CPXB_BACME
A:
[5-452]
-------
M
P
Q
P
K
T
F
G
E
L
K
N
L
P
L
L
N
T
D
K
P
--
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
-
D
E
S
R
F
D
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
----------
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
-
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
-
H
I
E
V
P
E
D
-
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
-
G
E
Q
S
D
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
--
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
-----
P
E
G
F
V
V
K
A
K
S
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
90.60
67%
-95
- C3 -
1JPZ
2
CPXB_BACME
B:
[8-455]
-------
M
P
Q
P
K
T
F
G
E
L
K
N
L
P
L
L
N
T
D
K
P
--
V
Q
A
L
M
K
I
A
D
E
L
G
E
I
F
K
F
E
A
P
G
R
V
T
R
Y
L
S
S
Q
R
L
I
K
E
A
C
-
D
E
S
R
F
D
K
N
L
S
Q
A
L
K
F
V
R
D
F
A
----------
G
D
G
L
F
T
S
W
T
H
E
K
N
W
K
K
A
H
N
I
L
L
P
S
F
S
Q
Q
A
M
K
-
G
Y
H
A
M
M
V
D
I
A
V
Q
L
V
Q
K
W
E
R
L
N
A
D
E
-
H
I
E
V
P
E
D
-
M
T
R
L
T
L
D
T
I
G
L
C
G
F
N
Y
R
F
N
S
F
Y
R
D
Q
P
H
P
F
I
T
S
M
V
R
A
L
D
E
A
M
N
K
L
Q
R
A
N
P
D
D
P
A
Y
D
E
N
K
R
Q
F
Q
E
D
I
K
V
M
N
D
L
V
D
K
I
I
A
D
R
K
A
S
-
G
E
Q
S
D
D
L
L
T
H
M
L
N
G
K
D
P
E
T
G
E
P
L
D
D
E
N
I
R
Y
Q
I
I
T
F
L
I
A
G
H
E
T
T
S
G
L
L
S
F
A
L
Y
F
L
V
K
N
P
H
V
L
Q
K
A
A
E
E
A
A
R
V
L
V
D
P
V
P
S
Y
K
Q
V
K
Q
L
K
Y
V
G
M
V
L
N
E
A
L
R
L
W
P
T
A
P
-
A
F
S
L
Y
A
K
E
D
T
V
L
G
G
E
Y
P
L
E
K
G
D
E
L
M
V
L
I
P
Q
L
H
R
D
K
T
I
W
G
D
D
V
E
E
F
R
P
E
R
F
E
N
P
--
S
A
I
P
Q
H
A
F
K
P
F
G
N
G
Q
R
A
C
I
G
Q
Q
F
A
L
H
E
A
T
L
V
L
G
M
M
L
K
H
F
D
F
E
D
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
-----
P
E
G
F
V
V
K
A
K
S
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
90.59
67%
-96
- C3 -
1ZO9
9
CPXB_BACME
B:
[8-455]
-------
M
P
Q
P
K
T
F
G
E
L
K
N
L
P
L
L
N
T
D
K
P
--
V
Q
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M
K
I
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D
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L
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A
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-
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F
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N
L
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Q
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L
K
F
V
R
D
F
A
----------
G
D
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N
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A
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--
S
A
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A
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N
G
Q
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A
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I
G
Q
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A
L
H
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L
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M
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L
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H
F
D
F
E
D
H
T
N
Y
E
L
D
I
K
E
T
L
T
L
K
-----
P
E
G
F
V
V
K
A
K
S
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------