@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu27410: (2016-07-12 )
MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSGVATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKEEAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWDIGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYTPLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFKVIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAEIMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADVFKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGALRDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIGDKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNHTATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWASIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLFKIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAELKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAKLGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAGGKQPEKLEEALASVEDWVKSVL
Atome Classification :
(28 SA)
.........10........20........30........40........50...-.....-----60-----........70.----.......80........90.......-----.100.......110.......120.......130.--------.--------.....140.......150--..---------.....160-.-......170....----..-.180.......190.......200.......210...-------....220.......230.......240.....--------------------..250.......----260..--..------.------.-----------------------------------------------.270.-----.----------------.....280.......290.......300.......310...-.-...320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......-420-........430..-.....440.......450.-......460...---....470.......480.......490--........500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640......--..650-.......660.......670.......680.......690.......700.......710.......720-.......730.......740.......750.......760.......770.......780.......790.......800.......810.....--..820.......830.......840.......850.......860.......870......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKHL
T
S
A
E
V
R
Q
M
F
L
D
F
F
K
EKGHAVEPSASLVPHEDP
S
L
L
W
INS
G
V
A
T
L
K
K
Y
FDG-RVVPE-----NP-----
R
I
V
N
A
Q
K
AIRT----N
D
I
E
N
V
G
K
T
A
R
H
H
T
F
F
E
M
L
GNFS
I
G
D
-----
Y
F
K
E
E
A
I
T
W
A
W
E
F
LTSDKWIGF
D
K
E
L
L
S
V
T
VHPE
D
--------
E
--------
E
A
Y
E
F
W
A
K
KIGI
P
E
E
R
I
I
--
R
L
---------EG
N
F
W
DIG-E-GPSGPNT
E
I
F
Y
DR----GE-AYGNDPEDPELYPGGEND
R
Y
L
E
V
W
N
L
V
F
S
EFNHNPDG-------TYTPLPKKNIDTGM
G
L
E
R
M
V
S
V
I
Q
NVPTNFDT--------------------D
L
F
V
P
I
I
K
A
T
ES----ISGET--YG------K------D-----------------------------------------------NV
K
D
T
-----
A
----------------
F
K
V
I
A
D
H
I
R
T
V
A
F
AVSDGALPSNEG
R
G
Y
V
L
R
R
L
L
R
R
A
V
R
Y
A
-
K
-
T
INIHR
P
F
M
F
D
L
V
P
V
V
A
E
I
M
A
D
F
Y
P
E
V
K
E
K
A
D
F
I
A
K
V
I
K
T
E
E
E
R
F
H
E
T
L
N
E
G
L
A
I
L
S
E
M
I
K
K
EKDKGSSVISG
A
D
V
F
K
L
YDTYGF
P
V
E
L
T
E
E
YAEDENMTVDH-E
G
--
F
E
E
E
M
N
Q
Q
R
E
R
A
R
-
N
A
R
Q
DVG
S
M
Q
VQGG
A
L
R
D
V
-
T
VE
S
T
F
VGYSQT---KAD
A
N
I
I
V
L
LQD
G
Q
L
I
E
E
AHEG
E
S
V
Q
---
I
I
LDETPFYAESGGQIGDKGYLRSE
Q
A
V
V
R
I
K
D
V
QKAPNG
Q
H
V
H
E
G
V
VESGTVQK
G
L
H
V
T
A
E
V
E
D
H
M
R
SGVIKN
H
T
A
T
H
L
L
H
Q
A
L
K
D
V
L
G
T
H
V
N
QAGSLVTEN
R
L
R
F
D
F
S
H
F
G
Q
V
T
K
E
E
L
E
Q
I
E
R
I
V
N
E
K
I
W
ASI
P
V
S
I
DL
K
P
I
A
E
A
K
E
M-
G
A
M
A
L
F
--
G
EKYG-
D
I
V
R
V
V
Q
VGD
Y
S
L
E
LCGGCHVRNTAEI
G
L
F
K
I
VSESGIGAG
T
R
R
I
E
A
VTGQ
G
A
Y
V
E
MN
S
Q
I
S
V
L
K
Q
T
A
D
E
-
L
K
T
N
I
K
E
V
P
K
R
V
A
A
L
Q
A
E
L
K
D
A
QRE
N
E
S
L
L
A
K
LGNV
E
A
G
A
I
L
S
K
V
K
EVDG
V
N
V
L
A
A
KVN
A
K
D
M
N
H
L
R
T
M
V
D
E
L
K
A
KLG
S
A
V
I
V
L
G
AVQND
K
V
N
IS--AGV
T
K
D
L
I
E
KGL
H
A
G
K
L
V
K
Q
A
A
E
VCGGGGGGR
P
D
M
A
QAGGK
Q
P
E
K
L
E
E
A
L
A
S
V
E
D
W
V
K
SVL
37
HHSearch
81.43
29%
24
* C1 *
3WQY
1
SYA_ARCFU
A:
[58-903]
-
K
P
F
E
L
D
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
V
T
S
G
V
A
P
P
P
-----
A
N
-----
P
L
T
I
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
---
E
L
G
V
K
K
E
D
I
V
--------------------------------
Y
----------------------
K
E
E
P
W
A
G
G
---
G
N
A
G
P
C
L
E
A
I
V
G
---------------------------
G
L
E
V
A
T
L
V
F
M
N
L
E
E
H
P
E
G
DIEIKG
A
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
G
T
P
T
V
Y
D
A
---------------------
I
F
P
E
V
V
D
T
I
I
D
----
N
S
N
V
S
--
F
N
------
R
------
E
D
E
R
V
R
R
I
V
A
E
S
S
K
L
A
G
I
M
G
E
L
RG
E
R
L
N
Q
L
R
K
S
V
A
D
T
V
GVS
V
E
E
L
E
G
I
V
V
P
L
E
-----
K
----------------
V
Y
S
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
-
E
-
E
L
E
L
G
L
-
D
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
E
F
D
V
---
P
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
R
L
V
E
R
-----
K
K
K
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
-
P
K
DI
Y
A
E
L
A
K
R
H
S
K
A
E
K
-
V
-
Q
E
K
K
I
--
T
L
Q
N
---
E
Y
P
A
T
E
K
L
---
Y
Y
D
D
P
TLL
E
F
E
A
E
V
I
G
V
E
-------------
G
D
F
---
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
G
K
F
E
V
V
D
V
L
E
A
D
-
G
V
V
L
H
V
V
K
G
--
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
F
G
F
R
L
Y
Q
--
G
G
V
P
P
G
R
K
I
R
V
V
Q
V
G
D
-
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
A
I
E
A
V
E
E
M
E
R
-
L
L
R
E
A
S
S
I
L
R
V
E
P
A
K
L
P
K
T
V
E
R
F
F
E
E
W
K
D
Q
R
K
E
I
E
R
L
K
S
V
I
A
D
L
W
A
D
I
L
M
E
R
A
E
E
F
D
S
M
K
V
V
A
-
E
V
V
D
A
D
M
Q
A
L
Q
K
L
A
E
R
L
A
E
K
G
-
A
-
V
G
C
L
M
A
K
G
E
G
K
V
F
V
V
--
T
F
S
G
-----
Q
K
Y
D
A
R
E
L
L
R
E
I
G
R
V
A
K
G
S
G
G
G
R
K
D
V
A
Q
G
A
V
Q
Q
L
L
D
R
E
E
M
L
D
V
I
F
R
F
L
S
E
--
17
PsiBlast_PDB
79.87
26%
27
- C1 -
3WQY
1
SYA_ARCFU
A:
[64-894]
-------
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
V
T
S
-
G
V
A
P
P
PA---
N
P
-----
L
T
I
-
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
E
---
L
G
V
K
K
E
D
I
V
Y
K
E
E
P
------------------------
W
A
-------------------------------
G
-
G
-
G
N
A
G
P
C
L
E
A
I
V
----------------------
G
G
-----
L
E
V
A
T
L
V
F
M
N
L
E
E
H
P
E
G
DIEIKG
A
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
G
T
P
T
V
Y
D
A
I
F
P
E
V
V
D
T
I
I
D
N
SNVSFNRE
D
E
R
V
R
R
I
V
A
E
S
S
K
L
A
G
I
M
G
E
L
--
R
G
E
R
L
N
Q
L
R
------
K
-----------------------------------------------
S
V
A
D
T
-----
V
GVS
V
E
E
L
E
G
I
V
V
P
L
E
K
V
Y
S
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
-
E
-
E
L
E
L
G
L
D
-
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
---
E
F
D
V
P
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
R
L
V
E
R
K
K
K
-----
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
P
K
D
--
I
Y
A
E
L
A
K
R
H
S
K
A
E
-
K
V
Q
E
------------
K
K
I
-
T
L
Q
N
E
Y
P
A
T
E
K
L
---
Y
Y
D
--------
D
P
T
L
L
E
F
E
A
E
V
I
G
V
E
GD
F
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
G
K
F
E
V
V
D
V
L
E
A
-
D
G
V
V
L
H
--
V
V
K
G
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
-
F
G
F
R
L
Y
QG
G
V
P
P
G
-
R
K
I
R
V
V
Q
V
G
D
-
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
A
I
E
A
V
E
E
M
E
R
L
L
R
E
A
S
S
I
-
L
R
V
E
P
A
K
L
P
K
T
V
E
R
F
F
E
E
W
K
D
Q
R
K
E
I
E
R
L
K
S
V
I
A
D
L
W
A
D
I
L
M
E
R
A
E
E
F
D
S
M
K
V
V
A
E
V
V
D
A
-
D
M
Q
A
L
Q
K
L
A
E
R
L
A
E
K
--
G
A
V
G
C
L
M
A
K
G
E
G
K
V
F
V
V
T
F
S
G
Q
K
Y
D
-------
A
R
E
L
L
R
E
I
G
R
V
A
K
G
S
G
G
G
R
K
D
V
A
Q
G
A
V
Q
Q
L
L
D
R
E
E
M
L
-----------
18
PsiBlast_PDB
78.46
26%
26
- C1 -
3WQZ
2
SYA_ARCFU
A:
[64-894]
-------
E
M
R
E
Y
Y
L
N
F
F
E
R
R
G
H
G
R
I
E
R
Y
P
V
V
A
R
W
R
T
D
I
Y
L
T
I
A
S
I
A
D
F
Q
P
F
V
T
S
-
G
V
A
P
P
PA---
N
P
-----
L
T
I
-
S
Q
P
C
I
R
L
----
D
D
L
D
S
V
G
R
T
G
R
H
L
T
L
F
E
M
M
A
H
H
A
F
N
Y
PGKEI
Y
W
K
N
E
T
V
A
Y
C
T
E
L
L
N
E
---
L
G
V
K
K
E
D
I
V
Y
K
E
E
P
------------------------
W
A
-------------------------------
G
-
G
-
G
N
A
G
P
C
L
E
A
I
V
----------------------
G
G
-----
L
E
V
A
T
L
V
F
M
N
L
E
E
H
P
E
G
DIEIKG
A
R
Y
R
K
M
D
N
Y
I
V
D
T
G
Y
G
L
E
R
F
V
W
A
S
K
G
T
P
T
V
Y
D
A
I
F
P
E
V
V
D
T
I
I
D
N
SNVSFNRE
D
E
R
V
R
R
I
V
A
E
S
S
K
L
A
G
I
M
G
E
L
--
R
G
ER
L
N
Q
L
R
------
K
-----------------------------------------------
S
V
A
D
T
-----
V
GVS
V
E
E
L
E
G
I
V
V
P
L
E
K
V
Y
S
L
A
D
H
T
R
C
I
L
F
M
L
G
D
G
L
V
P
S
N
A
G
A
G
Y
L
A
R
L
M
I
R
R
S
L
R
L
A
-
E
-
E
L
E
L
G
L
D
-
L
Y
D
L
V
E
M
H
K
K
I
L
G
F
---
E
F
D
V
P
L
S
T
V
Q
E
I
L
E
L
E
K
E
R
Y
R
T
T
V
S
K
G
T
R
L
V
E
R
L
V
E
R
K
K
K
-----
L
E
K
D
D
L
I
E
L
Y
D
S
H
G
I
P
V
E
L
A
V
G
I
A
A
E
K
G
A
E
V
E
M
P
K
D
--
I
Y
A
E
L
A
K
R
H
S
K
A
E
-
K
V
Q
E
------------
K
K
I
-
T
L
Q
N
E
Y
P
A
T
E
K
L
---
Y
Y
D
--------
D
P
T
L
L
E
F
E
A
E
V
I
G
V
E
GD
F
V
I
L
N
R
S
A
F
Y
P
E
S
G
G
Q
D
N
D
V
G
Y
L
I
A
N
G
G
K
F
E
V
V
D
V
L
E
A
-
D
G
V
V
L
H
--
V
V
K
G
A
K
P
E
V
G
T
K
V
K
G
V
I
D
S
D
V
R
W
R
H
M
R
H
H
S
A
T
H
V
L
L
Y
S
L
Q
K
V
L
G
N
H
V
W
Q
A
G
A
R
K
E
F
S
K
A
R
L
D
V
T
H
F
R
R
P
S
E
E
E
I
K
E
I
E
M
L
A
N
R
E
I
L
A
N
K
P
I
K
W
E
W
M
D
R
I
E
A
E
R
K
-
F
G
F
R
L
Y
QG
G
V
P
P
G
-
R
K
I
R
V
V
Q
V
G
D
-
D
V
Q
A
C
G
G
T
H
C
R
S
T
G
E
I
G
M
L
K
I
L
K
V
E
S
I
Q
D
G
V
I
R
F
E
F
A
A
G
E
A
A
I
E
A
V
E
E
M
E
R
L
L
R
E
A
S
S
I
-
L
R
V
E
P
A
K
L
P
K
T
V
E
R
F
F
E
E
W
K
D
Q
R
K
E
I
E
R
L
K
S
V
I
A
D
L
W
A
D
I
L
M
E
R
A
E
E
F
D
S
M
K
V
V
A
E
V
V
D
A
-
D
M
Q
A
L
Q
K
L
A
E
R
L
A
E
K
--
G
A
V
G
C
L
M
A
K
G
E
G
K
V
F
V
V
T
F
S
G
Q
K
Y
D
-------
A
R
E
L
L
R
E
I
G
R
V
A
K
G
S
G
G
G
R
K
D
V
A
Q
G
A
V
Q
Q
L
L
D
R
E
E
M
L
-----------
40
HHSearch
74.38
50%
21
- C1 -
3HY0
4
SYA_ECOLI
A:
[1-439]
--
S
K
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
--
R
I
G
DNKGAPYA
S
D
N
F
W
Q
M
G
D
T
-
G
P
C
G
P
C
T
E
I
F
Y
D
H
----
G
D
-
H
I
W
G
G
---
P
P
G
S
P
E
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
--------------------
D
L
F
R
T
L
I
Q
A
V
A
K
----
V
T
G
A
T
--
D
---------------------------------------------------------------
L
S
N
K
-----
S
----------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
L
---
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
-
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-
E
A
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
73.86
48%
34
- C1 -
3HXZ
6
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
--
R
I
G
DNKGAPYA
S
D
N
F
W
Q
M
G
-
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
----
G
D
H
I
W
G
G
P
P
G
S
P
E
----
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
--------------------
D
L
F
R
T
L
I
Q
A
V
A
K
----
V
T
G
A
T
-----------------------------------------------------------------
D
L
S
N
K
-----
S
----------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
---
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
-
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.85
46%
6
- C1 -
1RIQ
-
SYA_AQUAE
A:
[2-453]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
-----
Y
K
-----
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
--------
E
--------
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
--
R
L
G
E-------
E
D
N
F
W
Q
M
G
-
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
----
G
E
-
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
N
F
E
I
--------------------
D
I
I
F
P
L
I
Q
F
G
E
E
----
V
S
G
K
K
--
Y
G
------
E
------
K
-----------------------------------------------
F
E
T
D
V
-----
A
----------------
L
R
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
-
E
G
--
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
---------
P
V
Y
S
H
L
K
E
L
-
G
K
T
S
A
F
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
73.77
48%
34
- C1 -
3HXZ
4
SYA_ECOLI
C:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
--
R
I
GDNKGAPYA
S
D
N
F
W
Q
M
G
-
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
----
G
D
H
I
W
G
G
P
P
G
S
P
E
----
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
--------------------
D
L
F
R
T
L
I
Q
A
V
A
K
----
V
T
G
A
T
-----------------------------------------------------------------
D
L
S
N
K
-----
S
----------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
---
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
-
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
73.65
48%
33
- C1 -
3HY0
4
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
--
R
I
G
DNKGAPYA
S
D
N
F
W
Q
M
G
-
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
----
G
D
H
I
W
G
G
P
P
G
S
P
E
----
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
--------------------
D
L
F
R
T
L
I
Q
A
V
A
K
----
V
T
G
A
T
-----------------------------------------------------------------
D
L
S
N
K
-----
S
----------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
---
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
-
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
73.57
48%
32
- C1 -
3HXZ
4
SYA_ECOLI
D:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
--
R
I
GDNKGAPYA
S
D
N
F
W
Q
M
G
-
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
----
G
D
H
I
W
G
G
P
P
G
S
P
E
----
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
--------------------
D
L
F
R
T
L
I
Q
A
V
A
K
----
V
T
G
A
T
-----------------------------------------------------------------
D
L
S
N
K
-----
S
----------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
---
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
-
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
73.50
48%
34
- C1 -
3HXZ
6
SYA_ECOLI
B:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
--
R
I
GDNKGAPYA
S
D
N
F
W
Q
M
G
-
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
----
G
D
H
I
W
G
G
P
P
G
S
P
E
----
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
--------------------
D
L
F
R
T
L
I
Q
A
V
A
K
----
V
T
G
A
T
-----------------------------------------------------------------
D
L
S
N
K
-----
S
----------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
---
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
-
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.37
48%
33
- C1 -
3HXU
5
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
--
R
I
G
DNKGAPYA
S
D
N
F
W
Q
M
G
-
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
----
G
D
H
I
W
G
G
P
P
G
S
P
E
----
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
--------------------
D
L
F
R
T
L
I
Q
A
V
A
K
----
V
T
G
A
T
-----------------------------------------------------------------
D
L
S
N
K
-----
S
----------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
---
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
-
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
73.36
46%
10
- C1 -
1YFS
1
SYA_AQUAE
B:
[3-454]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
-----
Y
K
-----
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
--------
E
--------
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
--
R
L
GE-------
E
D
N
F
W
Q
M
G
-
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
----
G
E
-
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
N
F
E
I
--------------------
D
I
I
F
P
L
I
Q
F
G
E
E
----
V
S
G
K
K
--
Y
G
------
E
------
K
-----------------------------------------------
F
E
T
D
V
-----
A
----------------
L
R
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
-
E
G
--
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
---------
P
V
Y
S
H
L
K
E
L
-
G
K
T
S
A
F
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.34
48%
34
- C1 -
3HXW
5
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
--
R
I
G
DNKGAPYA
S
D
N
F
W
Q
M
G
-
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
----
G
D
H
I
W
G
G
P
P
G
S
P
E
----
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
--------------------
D
L
F
R
T
L
I
Q
A
V
A
K
----
V
T
G
A
T
-----------------------------------------------------------------
D
L
S
N
K
-----
S
----------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
---
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
-
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.27
48%
32
- C1 -
3HXV
6
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
--
R
I
G
DNKGAPYA
S
D
N
F
W
Q
M
G
-
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
----
G
D
H
I
W
G
G
P
P
G
S
P
E
----
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
--------------------
D
L
F
R
T
L
I
Q
A
V
A
K
----
V
T
G
A
T
-----------------------------------------------------------------
D
L
S
N
K
-----
S
----------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
---
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
-
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
73.25
48%
30
- C1 -
3HXY
5
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
--
R
I
G
DNKGAPYA
S
D
N
F
W
Q
M
G
-
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
----
G
D
H
I
W
G
G
P
P
G
S
P
E
----
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
--------------------
D
L
F
R
T
L
I
Q
A
V
A
K
----
V
T
G
A
T
-----------------------------------------------------------------
D
L
S
N
K
-----
S
----------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
---
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
-
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
73.25
48%
31
- C1 -
3HXX
3
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
--
R
I
G
DNKGAPYA
S
D
N
F
W
Q
M
G
-
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
----
G
D
H
I
W
G
G
P
P
G
S
P
E
----
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
G
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
--------------------
D
L
F
R
T
L
I
Q
A
V
A
K
----
V
T
G
A
T
-----------------------------------------------------------------
D
L
S
N
K
-----
S
----------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
---
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
-
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
72.88
48%
33
- C1 -
3HY0
4
SYA_ECOLI
B:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
--
R
I
GDNKGAPYA
S
D
N
F
W
Q
M
G
-
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
----
G
D
H
I
W
G
G
P
P
G
S
P
E
----
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
--------------------
D
L
F
R
T
L
I
Q
A
V
A
K
----
V
T
G
A
T
-----------------------------------------------------------------
D
L
S
N
K
-----
S
----------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
---
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
-
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
72.87
46%
4
- C1 -
3HTZ
-
SYA_AQUAE
A:
[2-453]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
-----
Y
K
-----
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
--------
E
--------
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
--
R
L
G
E-------
E
D
N
F
W
Q
M
G
-
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
----
G
E
-
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
N
F
E
I
--------------------
D
I
I
F
P
L
I
Q
F
G
E
E
----
V
S
G
K
K
--
Y
G
------
E
------
K
-----------------------------------------------
F
E
T
D
V
-----
A
----------------
L
R
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
-
E
G
--
F
Q
C
E
L
E
E
Q
R
E
R
A
R
----------
K
P
V
Y
S
H
L
K
E
L
-
G
K
T
S
A
F
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
72.83
46%
5
- C1 -
1YFS
1
SYA_AQUAE
A:
[3-454]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
-----
Y
K
-----
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
--------
E
--------
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
--
R
L
G
E-------
E
D
N
F
W
Q
M
G
-
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
----
G
E
-
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
N
F
E
I
--------------------
D
I
I
F
P
L
I
Q
F
G
E
E
----
V
S
G
K
K
--
Y
G
------
E
------
K
-----------------------------------------------
F
E
T
D
V
-----
A
----------------
L
R
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
-
E
G
--
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
---------
P
V
Y
S
H
L
K
E
L
-
G
K
T
S
A
F
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
72.79
48%
29
- C1 -
3HY1
4
SYA_ECOLI
A:
[3-438]
----
S
T
A
E
I
R
Q
A
F
L
D
F
F
H
S
K
G
H
Q
V
V
A
S
S
S
L
V
P
H
N
D
P
T
L
L
F
T
N
A
G
M
N
Q
F
K
D
V
F
L
G
-
L
D
K
R
N
-----
Y
S
-----
R
A
T
T
S
Q
R
C
V
R
A
GGKH
N
D
L
E
N
V
G
Y
T
A
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
L
D
A
I
L
F
A
W
L
L
L
T
S
E
K
W
F
A
L
P
K
E
R
L
W
V
T
V
Y
E
S
D
--------
D
--------
E
A
Y
E
I
W
E
K
E
V
G
I
P
R
E
R
I
I
--
R
I
G
DNKGAPYA
S
D
N
F
W
Q
M
G
-
D
T
G
P
C
G
P
C
T
E
I
F
Y
D
H
----
G
D
H
I
W
G
G
P
P
G
S
P
E
----
E
D
G
D
R
Y
I
E
I
W
N
I
V
F
M
Q
F
N
R
Q
A
D
G
-------
T
M
E
P
L
P
K
P
S
V
D
T
A
M
G
L
E
R
I
A
A
V
L
Q
H
V
N
S
N
Y
D
I
--------------------
D
L
F
R
T
L
I
Q
A
V
A
K
----
V
T
G
A
T
-----------------------------------------------------------------
D
L
S
N
K
-----
S
----------------
L
R
V
I
A
D
H
I
R
S
C
A
F
L
I
A
D
G
V
M
P
S
N
E
N
R
G
Y
V
L
R
R
I
I
R
R
A
V
R
H
G
-
N
-
M
L
G
A
K
E
T
F
F
Y
K
L
V
G
P
L
I
D
V
M
G
S
A
G
E
D
L
K
R
Q
Q
A
Q
V
E
Q
V
L
K
T
E
E
E
Q
F
A
R
T
L
E
R
G
L
A
L
L
D
E
E
L
A
K
---
L
S
G
D
T
L
D
G
E
T
A
F
R
L
Y
D
T
Y
G
F
P
V
D
L
T
A
D
V
C
R
E
R
N
I
K
V
D
E
-
A
G
--
F
E
A
A
M
E
E
Q
R
R
R
A
R
-
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
72.72
46%
6
- C1 -
1YFR
3
SYA_AQUAE
A:
[3-454]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
-----
Y
K
-----
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
--------
E
--------
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
--
R
L
G
E-------
E
D
N
F
W
Q
M
G
-
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
----
G
E
-
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
N
F
E
I
--------------------
D
I
I
F
P
L
I
Q
F
G
E
E
----
V
S
G
K
K
--
Y
G
------
E
------
K
-----------------------------------------------
F
E
T
D
V
-----
A
----------------
L
R
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
-
E
G
--
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
---------
P
V
Y
S
H
L
K
E
L
-
G
K
T
S
A
F
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
72.46
46%
8
- C1 -
1YGB
1
SYA_AQUAE
A:
[3-454]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
-----
Y
K
-----
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
--------
E
--------
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
--
R
L
G
E-------
E
D
N
F
W
Q
M
G
-
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
----
G
E
-
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
N
F
E
I
--------------------
D
I
I
F
P
L
I
Q
F
G
E
E
----
V
S
G
K
K
--
Y
G
------
E
------
K
-----------------------------------------------
F
E
T
D
V
-----
A
----------------
L
R
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
-
E
G
--
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
---------
P
V
Y
S
H
L
K
E
L
-
G
K
T
S
A
F
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
71.98
46%
10
- C1 -
1YFT
1
SYA_AQUAE
A:
[3-454]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
-----
Y
K
-----
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
--------
E
--------
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
--
R
L
G
E-------
E
D
N
F
W
Q
M
G
-
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
----
G
E
-
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
N
F
E
I
--------------------
D
I
I
F
P
L
I
Q
F
G
E
E
----
V
S
G
K
K
--
Y
G
------
E
------
K
-----------------------------------------------
F
E
T
D
V
-----
A
----------------
L
R
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
-
E
G
--
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
---------
P
V
Y
S
H
L
K
E
L
-
G
K
T
S
A
F
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
71.54
46%
7
- C1 -
1YFR
4
SYA_AQUAE
B:
[3-454]
---
L
S
A
H
E
I
R
E
L
F
L
S
F
F
E
K
K
G
H
T
R
V
K
S
A
P
L
V
P
E
N
D
P
T
L
L
F
V
N
A
G
M
V
P
F
K
N
V
F
L
G
-
L
E
K
R
P
-----
Y
K
-----
R
A
T
S
C
Q
K
C
L
R
V
SGKH
N
D
L
E
Q
V
G
Y
T
S
R
H
H
T
F
F
E
M
L
G
N
F
S
F
G
D
-----
Y
F
K
K
E
A
I
E
Y
A
W
E
F
V
T
--
E
V
L
K
L
P
K
E
K
L
Y
V
S
V
Y
K
D
D
--------
E
--------
E
A
Y
R
I
W
N
E
H
I
G
I
P
S
E
R
I
W
--
R
L
GE-------
E
D
N
F
W
Q
M
G
-
D
V
G
P
C
G
P
S
S
E
I
Y
V
D
R
----
G
E
-
E
Y
E
G
D
------------
E
R
Y
L
E
I
W
N
L
V
F
M
Q
Y
N
R
D
E
N
G
-------
V
L
T
P
L
P
H
P
N
I
D
T
G
M
G
L
E
R
I
A
S
V
L
Q
G
K
N
S
N
F
E
I
--------------------
D
I
I
F
P
L
I
Q
F
G
E
E
----
V
S
G
K
K
--
Y
G
------
E
------
K
-----------------------------------------------
F
E
T
D
V
-----
A
----------------
L
R
V
I
A
D
H
L
R
A
I
T
F
A
I
S
D
G
V
I
P
S
N
E
G
R
G
Y
V
I
R
R
I
L
R
R
A
M
R
F
G
-
Y
-
K
L
G
I
E
N
P
F
L
Y
K
G
V
D
L
V
V
D
I
M
K
E
P
Y
P
E
L
E
L
S
R
E
F
V
K
G
I
V
K
G
E
E
K
R
F
I
K
T
L
K
A
G
M
E
Y
I
Q
E
V
I
Q
K
A
L
E
E
G
R
K
T
L
S
G
K
E
V
F
T
A
Y
D
T
Y
G
F
P
V
D
L
I
D
E
I
A
R
E
K
G
L
G
I
D
L
-
E
G
--
F
Q
C
E
L
E
E
Q
R
E
R
A
R
K
H
---------
P
V
Y
S
H
L
K
E
L
-
G
K
T
S
A
F
V
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
65.25
45%
17
- C1 -
4XEM
6
?
A:
[24-404]
--
T
L
T
A
S
E
I
R
Q
R
F
I
D
F
F
K
R
N
E
H
T
Y
V
H
S
S
A
T
I
P
L
D
D
P
T
L
L
F
A
N
A
G
M
N
Q
F
K
P
I
F
L
N
-
T
I
D
P
S
HPMAK
L
S
-----
R
A
A
N
T
Q
K
C
I
R
A
G----
D
L
D
D
V
G
K
D
V
Y
H
H
T
F
F
E
M
L
G
S
W
S
F
G
D
-----
Y
F
K
E
L
A
C
K
M
A
L
E
L
L
T
--
Q
E
F
G
I
P
I
E
R
L
Y
V
T
Y
F
G
G
D
EAAGLEAD
L
--------
E
C
K
Q
I
W
Q
N
-
L
G
L
D
D
T
K
I
L
--
P
G
N
M-------
K
D
N
F
W
E
M
G
D
T
-
G
P
C
G
P
C
S
E
I
H
Y
D
R
----
I
G
-
G
R
D
A
-----
A
H
L
V
N
Q
D
D
P
N
V
L
E
I
W
N
L
V
F
I
Q
Y
N
R
E
A
D
G
-------
I
L
K
P
L
P
K
K
S
I
D
T
G
M
G
L
E
R
L
V
S
V
L
Q
N
K
M
S
N
Y
D
T
--------------------
D
L
F
V
P
Y
F
E
A
I
Q
K
----
G
T
G
A
R
P-
Y
T
------
G
KVGAED
A
-----------------------------------------------
D
G
I
D
M
-----
A
----------------
Y
R
V
L
A
D
H
A
R
T
I
T
V
A
L
A
D
G
G
R
P
D
N
T
G
R
G
Y
V
L
R
R
I
L
R
R
A
V
R
Y
A
-
H
E
K
L
N
A
S
R
G
F
F
A
T
L
V
D
V
V
V
Q
S
L
G
D
A
F
P
E
L
K
K
D
P
D
M
V
K
D
I
I
N
E
E
E
V
Q
F
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
64.50
43%
22
- C1 -
4XEO
6
SYAC_HUMAN
A:
[25-408]
---
L
T
A
S
E
I
R
Q
R
F
I
D
F
F
K
R
N
E
H
T
Y
V
H
S
S
A
T
I
P
L
D
D
P
T
L
L
F
A
N
A
G
M
N
Q
F
K
P
I
F
L
N
-
T
I
D
P
S
-----
H
P
MAKLS
R
A
A
N
T
Q
K
C
I
R
A
GGKH
N
-
L
D
D
V
G
K
D
V
Y
H
H
T
F
F
E
M
L
G
S
W
S
F
G
D
-----
Y
F
K
E
L
A
C
K
M
A
L
E
L
L
T
Q
E
--
F
G
I
P
I
E
R
L
Y
V
T
Y
F
G
G
D
--------
E
AAGLEAD
L
E
C
K
Q
I
W
-
Q
N
L
G
L
D
D
T
K
I
L
P
G
N
M
---------
K
D
N
F
W
E
M
G
-
D
T
G
P
C
G
P
C
S
E
I
H
Y
D
R
IGGR
D
A
-
A
H
L
V
N
Q
D
D
P
N
V
---------
L
E
I
W
N
L
V
F
I
Q
Y
N
R
E
A
D
G
-------
I
L
K
P
L
P
K
K
S
I
D
T
G
M
G
L
E
R
L
V
S
V
L
Q
N
K
M
S
N
Y
D
T
--------------------
D
L
F
V
P
Y
F
E
A
I
Q
K
----
G
T
G
A
R
PY
T
G
------
K
------
V
-----------------------------------------------
G
A
E
D
A
DG
I
D
M
A
----------------
Y
R
V
L
A
D
H
A
R
T
I
T
V
A
L
A
D
G
G
R
P
D
N
T
G
R
G
Y
V
L
R
R
I
L
H
R
A
V
R
Y
A
H
E
-
K
L
N
A
S
R
G
F
F
A
T
L
V
D
V
V
V
Q
S
L
G
D
A
F
P
E
L
K
K
D
P
D
M
V
K
D
I
I
N
E
E
E
V
Q
F
L
K
T
L
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
64.49
43%
16
- C1 -
4XEM
6
?
A:
[25-404]
---
L
T
A
S
E
I
R
Q
R
F
I
D
F
F
K
R
N
E
H
T
Y
V
H
S
S
A
T
I
P
L
D
D
P
T
L
L
F
A
N
A
G
M
N
Q
F
K
P
I
F
L
N
-
T
I
D
P
S
-----
H
P
MAKLS
R
A
A
N
T
Q
K
C
I
R
A
G----
D
L
D
D
V
G
K
D
V
Y
H
H
T
F
F
E
M
L
G
S
W
S
F
G
D
-----
Y
F
K
E
L
A
C
K
M
A
L
E
L
L
T
Q
E
--
F
G
I
P
I
E
R
L
Y
V
T
Y
F
G
G
D
--------
E
AAGLEAD
L
E
C
K
Q
I
W
-
Q
N
L
G
L
D
D
T
K
I
L
P
G
N
M
---------
K
D
N
F
W
E
M
G
-
D
T
G
P
C
G
P
C
S
E
I
H
Y
D
R
IGGR
D
A
-
A
H
L
V
N
Q
D
D
P
N
V
---------
L
E
I
W
N
L
V
F
I
Q
Y
N
R
E
A
D
G
-------
I
L
K
P
L
P
K
K
S
I
D
T
G
M
G
L
E
R
L
V
S
V
L
Q
N
K
M
S
N
Y
D
T
--------------------
D
L
F
V
P
Y
F
E
A
I
Q
K
----
G
T
G
A
R
PY
T
G
------
K
------
V
-----------------------------------------------
G
A
E
D
A
DG
I
D
M
A
----------------
Y
R
V
L
A
D
H
A
R
T
I
T
V
A
L
A
D
G
G
R
P
D
N
T
G
R
G
Y
V
L
R
R
I
L
R
R
A
V
R
Y
A
H
E
-
K
L
N
A
S
R
G
F
F
A
T
L
V
D
V
V
V
Q
S
L
G
D
A
F
P
E
L
K
K
D
P
D
M
V
K
D
I
I
N
E
E
E
V
Q
F
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
64.28
43%
30
- C1 -
4XEO
8
SYAC_HUMAN
B:
[25-405]
---
L
T
A
S
E
I
R
Q
R
F
I
D
F
F
K
R
N
E
H
T
Y
V
H
S
S
A
T
I
P
L
D
D
P
T
L
L
F
A
N
A
G
M
N
Q
F
K
P
I
F
L
N
-
T
I
D
P
S
-----
H
P
MAKLS
R
A
A
N
T
Q
K
C
I
R
A
-----
D
L
D
D
V
G
K
D
V
Y
H
H
T
F
F
E
M
L
G
S
W
S
F
G
D
-----
Y
F
K
E
L
A
C
K
M
A
L
E
L
L
T
Q
E
--
F
G
I
P
I
E
R
L
Y
V
T
Y
F
G
G
D
--------
E
AAGLEAD
L
E
C
K
Q
I
W
-
Q
N
L
G
L
D
D
T
K
I
L
P
G
N
M
---------
K
D
N
F
W
E
M
G
-
D
T
G
P
C
G
P
C
S
E
I
H
Y
D
R
IGGR
D
A
-
A
H
L
V
N
Q
D
D
P
N
V
---------
L
E
I
W
N
L
V
F
I
Q
Y
N
R
E
A
D
G
-------
I
L
K
P
L
P
K
K
S
I
D
T
G
M
G
L
E
R
L
V
S
V
L
Q
N
K
M
S
N
Y
D
T
--------------------
D
L
F
V
P
Y
F
E
A
I
Q
K
----
G
T
G
A
R
PY
T
G
------
K
------
V
-----------------------------------------------
G
A
E
D
A
DG
I
D
M
A
----------------
Y
R
V
L
A
D
H
A
R
T
I
T
V
A
L
A
D
G
G
R
P
D
N
T
G
R
G
Y
V
L
R
R
I
L
H
R
A
V
R
Y
A
H
E
-
K
L
N
A
S
R
G
F
F
A
T
L
V
D
V
V
V
Q
S
L
G
D
A
F
P
E
L
K
K
D
P
D
M
V
K
D
I
I
N
E
E
E
V
Q
F
L
K
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------