@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu27510: (2016-07-13 )
MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESRKWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHAVLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIEEIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDVKLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLRDAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSHVLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT
Atome Classification :
(27 SA)
.........10........20......--..30....-....40........50........60.........70........80....---.-------.---.---.-90.-----....-....100.......110..-..-....120..-.....130......--.140.......150.......160......----------.----------170.......180.......190.......200.......210....-------.--.--.220-----...---..---....230.......240.......250....--------...260.......270...----....280....-..----.290.......300.--......310-.......320......-.-330.......340.......350.......360.......370.......-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
E
R
I
Y
LDHAATS
P
M
D
E
R
V
L
E
Q
M
I
P
H
FS--GSFG
N
P
S
S
-
I
H
S
F
G
R
E
S
R
K
W
V
D
E
A
R
A
Q
I
A
A
E
IGA-A
E
Q
E
I
I
F
TSGGTEAD
N
L
A
I
M
G
T
A
L
A
---
R
-------
K
---
D
---L-G-
R
-----
H
I
I
T
-
T
K
I
E
H
H
A
V
L
H
T
C
E
K
L-EGD-G
F
-
D
I
T
Y
L
DVDQ-NGRV
S
A
K
Q
V
K
E
A
LR--DD
T
I
L
V
T
V
M
YGNNEVG
T
V
Q
P
I
E
E
I
G
E
L
L
K
E
----------
H
----------
K
A
Y
F
H
T
D
A
V
Q
A
FG
L
L
P
I
DVKNS
H
I
D
L
L
SVSGHKLNGPKGT
G
F
L
Y
ASK-------D--
V
--
K
L
-------
S
P
L
---
L
F---G
G
E
Q
E
R
K
RRAGTENVP
G
I
V
G
L
K
E
A
I
K
LSSEE--------RD
E
K
N
E
K
Y
Q
S
F
K
A
I
F
A
D
T
L
----
R
DA
G
V
A
F
E
VNG-DK----EHSL
P
H
V
L
N
L
YFPGV--S
V
E
A
L
L
V
NL-DMA
G
V
A
VSSGSACTAG-S-
V
L
P
S
H
V
L
T
A
M
FGEESDRL
T
S
S
I
R
I
S
FGLG
N
T
A
E
Q
V
K
T
A
A
K
H
V
A
D
V
V
K
RLT-----
23
PsiBlast_CBE
75.59
38%
-84
- C2 -
4EB5
5
ISCS2_ARCFU
B:
[3-373]
----
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
-
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
-
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
A
M
R
---
N
-------
A
---
R
---
K
-
G
-
K
-----
H
I
L
V
-
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
-
G
F
-
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
A
-----------
G
----------
K
A
A
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
K
-------
E
--
A
--
K
L
-------
Q
P
V
---
I
L
---
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
--------
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
V
----
L
K
I
E
E
S
Y
-
L
N
G
-
H
P
----
E
K
R
L
P
N
N
V
N
V
R
F
S
Y
I
--
E
G
E
S
I
V
L
S
L
-
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
K
-
T
-
L
Q
P
S
H
V
L
M
A
C
-
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
------
3
PsiBlast_PDB
75.49
39%
-80
- C2 -
4R5F
12
ISCS2_ARCFU
A:
[3-373]
----
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
-
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
-
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
A
M
R
---
N
-------
A
---
R
---
K
-
G
-
K
-----
H
I
L
V
-
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
-
G
F
-
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
A
-----------
G
----------
K
A
A
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
K
I
Y
G
P
K
G
V
G
A
L
W
I
R
K
-------
E
--
A
--
K
L
-------
Q
P
V
---
I
L
---
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
--------
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
V
----
L
K
I
E
E
S
Y
-
L
N
G
-
H
P
----
E
K
R
L
P
N
N
V
N
V
R
F
S
Y
I
--
E
G
E
S
I
V
L
S
L
-
D
M
A
G
I
Q
A
S
T
G
----------
Q
P
S
H
V
L
M
A
C
-
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
------
22
PsiBlast_CBE
75.01
38%
-83
- C2 -
4EB7
4
ISCS2_ARCFU
B:
[3-373]
----
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
-
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
-
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
A
M
R
---
N
-------
A
---
R
---
K
-
G
-
K
-----
H
I
L
V
-
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
-
G
F
-
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
A
-----------
G
----------
K
A
A
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
K
-------
E
--
A
--
K
L
-------
Q
P
V
---
I
L
---
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
--------
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
V
----
L
K
I
E
E
S
Y
-
L
N
G
-
H
P
----
E
K
R
L
P
N
N
V
N
V
R
F
S
Y
I
--
E
G
E
S
I
V
L
S
L
-
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
K
-
T
-
L
Q
P
S
H
V
L
M
A
C
-
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
------
4
PsiBlast_PDB
74.74
38%
-74
- C2 -
4EB5
6
ISCS2_ARCFU
A:
[3-373]
----
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
-
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
-
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
A
M
R
---
N
-------
A
---
R
---
K
-
G
-
K
-----
H
I
L
V
-
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
-
G
F
-
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
A
-----------
G
----------
K
A
A
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
K
-------
E
--
A
--
K
L
-------
Q
P
V
---
I
L
---
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
--------
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
V
----
L
K
I
E
E
S
Y
-
L
N
G
-
H
P
----
E
K
R
L
P
N
N
V
N
V
R
F
S
Y
I
--
E
G
E
S
I
V
L
S
L
-
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
K
-
T
-
L
Q
P
S
H
V
L
M
A
C
-
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
------
5
PsiBlast_PDB
74.69
38%
-75
- C2 -
4EB7
7
ISCS2_ARCFU
A:
[3-373]
----
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
-
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
-
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
A
M
R
---
N
-------
A
---
R
---
K
-
G
-
K
-----
H
I
L
V
-
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
-
G
F
-
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
A
-----------
G
----------
K
A
A
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
K
-------
E
--
A
--
K
L
-------
Q
P
V
---
I
L
---
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
--------
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
V
----
L
K
I
E
E
S
Y
-
L
N
G
-
H
P
----
E
K
R
L
P
N
N
V
N
V
R
F
S
Y
I
--
E
G
E
S
I
V
L
S
L
-
D
M
A
G
I
Q
A
S
T
G
S
A
C
S
S
--
T
-
L
Q
P
S
H
V
L
M
A
C
-
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
------
64
HHSearch
74.55
39%
-81
- C2 -
4HVK
12
ISCS2_ARCFU
A:
[2-373]
---
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
-
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
-
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
A
M
R
---
N
-------
A
---
R
---
K
-
G
-
K
-----
H
I
L
V
-
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
-
G
F
-
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
A
G
---------------------
K
A
A
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
K
-------
E
--
A
--
K
L
-------
Q
P
V
---
I
L
---
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
--------
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
V
----
L
K
I
-
E
E
S
Y
L
N
G
-
H
P
----
E
K
R
L
P
N
N
V
N
V
R
F
S
Y
I
--
E
G
E
S
I
V
L
S
L
-
D
M
A
G
I
Q
A
S
T
G
----------
Q
P
S
H
V
L
M
A
C
-
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
------
6
PsiBlast_PDB
74.22
38%
-80
- C2 -
4HVK
12
ISCS2_ARCFU
A:
[3-373]
----
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
--
E
S
F
G
N
P
S
S
-
V
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
-
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
A
M
R
---
N
-------
A
---
R
---
K
-
G
-
K
-----
H
I
L
V
-
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
-
G
F
-
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
A
-----------
G
----------
K
A
A
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
R
K
-------
E
--
A
--
K
L
-------
Q
P
V
---
I
L
---
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
--------
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
V
----
L
K
I
E
E
S
Y
-
L
N
G
-
H
P
----
E
K
R
L
P
N
N
V
N
V
R
F
S
Y
I
--
E
G
E
S
I
V
L
S
L
-
D
M
A
G
I
Q
A
S
T
G
----------
Q
P
S
H
V
L
M
A
C
-
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
------
53
Fugue
70.46
38%
-20
- C2 -
1ECX
2
?
A:
[1-376]
-
M
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
--
E
K
Y
G
N
P
N
S
-
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
-
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
A
E
T
---
F
-------
E
---
K
---
R
-
K
-
R
-----
T
I
I
T
-
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
K
-
G
F
-
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
K
K
----------
K
NK--------
E
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
K
-------
G
--
V
--
P
I
-------
R
P
L
---
I
H
---
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
--------
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
L
----
M
N
L
G
A
--
H
I
I
T
-
P
L
----
E
I
S
L
P
N
T
L
S
V
S
F
P
N
I
--
R
G
S
T
L
Q
N
L
L
-
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
-
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
25
PsiBlast_CBE
70.16
37%
-16
- C2 -
1ECX
2
?
B:
[2-376]
--
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
--
E
K
Y
G
N
P
N
S
-
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
-
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
A
E
T
---
F
-------
E
---
K
---
R
-
K
-
R
-----
T
I
I
T
-
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
K
-
G
F
-
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
K
K
KN--------
K
----------
E
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
K
-------
G
--
V
--
P
I
-------
R
P
L
---
I
H
---
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
--------
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
L
----
M
N
L
G
A
--
H
I
I
T
-
P
L
----
E
I
S
L
P
N
T
L
S
V
S
F
P
N
I
--
R
G
S
T
L
Q
N
L
L
-
S
G
Y
G
I
Y
V
S
T
-------------
R
H
V
L
D
A
M
-
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
10
PsiBlast_PDB
69.67
36%
-18
- C2 -
1EG5
3
?
A:
[2-376]
--
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
--
E
K
Y
G
N
P
N
S
-
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
-
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
A
E
T
---
F
-------
E
---
K
---
R
-
K
-
R
-----
T
I
I
T
-
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
K
-
G
F
-
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
K
K
K
N--------
K
----------
E
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
K
-------
G
--
V
--
P
I
-------
R
P
L
---
I
H
---
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
--------
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
L
----
M
N
L
G
A
--
H
I
I
T
-
P
L
----
E
I
S
L
P
N
T
L
S
V
S
F
P
N
I
--
R
G
S
T
L
Q
N
L
L
-
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
-
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
9
PsiBlast_PDB
69.63
37%
-20
- C2 -
1ECX
2
?
A:
[2-376]
--
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
--
E
K
Y
G
N
P
N
S
-
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
-
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
A
E
T
---
F
-------
E
---
K
---
R
-
K
-
R
-----
T
I
I
T
-
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
K
-
G
F
-
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
K
K
K
N--------
K
----------
E
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
K
-------
G
--
V
--
P
I
-------
R
P
L
---
I
H
---
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
--------
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
L
----
M
N
L
G
A
--
H
I
I
T
-
P
L
----
E
I
S
L
P
N
T
L
S
V
S
F
P
N
I
--
R
G
S
T
L
Q
N
L
L
-
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
-
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
2
PsiBlast_PDB
68.82
44%
25
- C2 -
3LVK
1
ISCS_ECO57
A:
[24-399]
---
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
MD
G
T
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
-
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
G
A
A
N
F
---
Y
-------
Q
---
K
---
K
-
G
-
K
-----
H
I
I
T
-
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
E
-
G
F
-
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
R
A
----------
R
----------
G
I
I
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
R
-------
K
P
R
V
--
R
I
-------
E
A
Q
---
M
H
---
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
K
E
E
--------
M
A
T
E
M
E
R
L
R
G
L
R
N
R
L
W
N
G
I
----
K
D
I
E
E
V
Y
-
L
N
G
-
D
L
----
E
H
G
A
P
N
I
L
N
V
S
F
N
Y
V
--
E
G
E
S
L
I
M
A
L
-
K
--
D
L
A
V
S
S
G
S
A
C
------
L
E
P
S
Y
V
L
R
A
L
-
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
------
21
PsiBlast_CBE
68.32
44%
25
- C2 -
3LVJ
2
ISCS_ECO57
B:
[24-399]
---
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
MD
G
T
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
-
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
G
A
A
N
F
---
Y
-------
Q
---
K
---
K
-
G
-
K
-----
H
I
I
T
-
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
E
-
G
F
-
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
R
A
----------
R
----------
G
I
I
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
R
-------
K
PR
V
--
R
I
-------
E
A
Q
---
M
H
---
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
K
E
E
--------
M
A
T
E
M
E
R
L
R
G
L
R
N
R
L
W
N
G
I
----
K
D
I
E
E
V
Y
-
L
N
G
-
D
L
----
E
H
G
A
P
N
I
L
N
V
S
F
N
Y
V
--
E
G
E
S
L
I
M
A
L
-
K
--
D
L
A
V
S
S
G
S
A
C
------
L
E
P
S
Y
V
L
R
A
L
-
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
------
54
Fugue
68.28
39%
13
- C2 -
4ISY
3
ISCSL_MYCTU
A:
[12-398]
--
S
A
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
V
Q
R
---
T
I
G
N
A
S
S
-
L
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
-
R
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
K
G
I
Y
W
A
---
R
-------
R
---
D
A
EP
H
-
R
-
R
-----
R
I
V
T
-
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
-
V
E
H
E
G
A
-
H
V
T
W
L
P
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
H
D
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
V
A
M
E
----------
F
----------
G
V
P
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
R
-------
D
--
V
--
T
C
-------
V
P
L
---
M
H
---
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
V
D
G
--------
L
E
E
N
S
A
R
L
R
L
L
R
D
R
L
V
E
G
V
----
L
A
E
I
D
D
V
C
L
N
G
A
D
D
----
P
M
R
L
A
G
N
A
H
F
T
F
R
G
C
--
E
G
D
A
L
L
M
L
L
-
D
A
N
G
I
E
C
S
T
G
S
----------
P
S
H
V
L
I
A
M
-
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
ALA
1
PsiBlast_PDB
68.24
44%
26
- C2 -
3LVJ
2
ISCS_ECO57
A:
[24-399]
---
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
A
E
K
M
M
Q
F
M
T
MD
G
T
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
-
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
G
A
A
N
F
---
Y
-------
Q
---
K
---
K
-
G
-
K
-----
H
I
I
T
-
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
E
-
G
F
-
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
R
A
----------
R
----------
G
I
I
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
R
-------
K
P
R
V
--
R
I
-------
E
A
Q
---
M
H
---
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
K
E
E
--------
M
A
T
E
M
E
R
L
R
G
L
R
N
R
L
W
N
G
I
----
K
D
I
E
E
V
Y
-
L
N
G
-
D
L
----
E
H
G
A
P
N
I
L
N
V
S
F
N
Y
V
--
E
G
E
S
L
I
M
A
L
-
K
--
D
L
A
V
S
S
G
-------
S
-
L
E
P
S
Y
V
L
R
A
L
-
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
------
70
HHSearch
67.50
40%
13
* C2 *
4ISY
3
ISCSL_MYCTU
A:
[12-392]
--
S
A
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
I
E
A
M
A
A
V
Q
R
--
T
-
I
G
N
A
S
S
-
L
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
-
R
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
K
G
I
Y
W
A
---
R
-------
R
D
A
E
P
---
H
-
R
-
R
-----
R
I
V
T
-
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
H
E
-
G
A
-
H
V
T
W
L
P
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
H
D
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
V
A
M
E
----------
F
----------
G
V
P
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
R
R
-------
D
--
V
--
T
C
-------
V
P
L
---
M
H
---
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
V
D
G
--------
L
E
E
N
S
A
R
L
R
L
L
R
D
R
L
V
E
G
V
----
L
A
E
I
D
D
V
C
L
N
G
-
A
D
D---
P
M
R
L
A
G
N
A
H
F
T
F
R
G
C
--
E
G
D
A
L
L
M
L
L
-
D
A
N
G
I
E
C
S
T
G
S
----------
P
S
H
V
L
I
A
M
-
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
------
66
HHSearch
67.41
37%
-3
- C2 -
1EG5
3
?
A:
[2-376]
--
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
L
E
E
M
I
V
F
Y
R
--
E
K
Y
G
N
P
N
S
-
A
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
-
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
A
E
T
---
F
-------
E
-------
K
-
R
-
K
-----
R
T
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
K
-
G
F
-
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
K
K
----------
K
NK--------
E
T
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
R
K
-------
G
--
V
--
P
I
-------
R
P
L
---
I
H
---
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
--------
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
L
----
M
N
L
--
G
A
H
I
I
T
-
P
L
----
E
I
S
L
P
N
T
L
S
V
S
F
P
N
I
--
R
G
S
T
L
Q
N
L
L
-
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
-
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
7
PsiBlast_PDB
65.63
41%
3
- C2 -
3VAX
1
?
A:
[23-379]
----
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
W
M
T
--
A
E
F
G
N
A
G
S
-
R
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
-
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
L
G
L
A
P
Y
---
G
-------
E
---
R
---
T
-
G
-
R
R----
H
I
I
T
-
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
-
A
G
R
-
G
F
-
E
V
D
F
L
T
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
--
P
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
R
A
----------
T
----------
P
T
Y
L
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
L
-
T
T
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
R
R
R
EEMDDE
R
--
V
--
P
L
-------
E
P
I
---
M
F
---
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
E
A
E
--------
H
A
Q
W
Q
V
A
A
Q
D
L
R
S
R
L
L
A
G
L
------
A
S
T
S
F
Q
V
N
G
-
D
Q
----
D
H
V
V
P
H
I
L
N
L
S
F
E
D
V
--
D
A
E
A
F
L
V
T
L
K
D
L
--
V
A
V
A
T
G
S
A
S
T
S
A
-
S
-
F
T
P
S
H
V
L
R
A
M
-
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
--------------------------
24
PsiBlast_CBE
65.06
41%
6
- C2 -
3VAX
2
?
B:
[23-379]
----
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
W
M
T
--
A
E
F
G
N
A
G
S
-
R
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
-
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
L
G
L
A
P
Y
---
G
-------
E
---
R
---
T
-
G
-
R
R----
H
I
I
T
-
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
-
A
G
R
-
G
F
-
E
V
D
F
L
T
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
--
P
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
R
A
----------
T
----------
P
T
Y
L
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
L
-
T
T
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
R
R
REEMDDE
R
--
V
--
P
L
-------
E
P
I
---
M
F
---
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
E
A
E
--------
H
A
Q
W
Q
V
A
A
Q
D
L
R
S
R
L
L
A
G
L
------
A
S
T
S
F
Q
V
N
G
-
D
Q
----
D
H
V
V
P
H
I
L
N
L
S
F
E
D
V
--
D
A
E
A
F
L
V
T
L
K
D
L
--
V
A
V
A
T
G
S
A
S
T
S
A
-
S
-
F
T
P
S
H
V
L
R
A
M
-
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
--------------------------
69
HHSearch
64.44
42%
4
- C2 -
3VAX
1
?
A:
[22-379]
---
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
A
D
I
V
L
H
W
M
T
--
A
E
F
G
N
A
G
S
-
R
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
-
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
L
G
L
A
P
Y
---
G
-------
E
---
R
---
T
-
G
R
R
-----
H
I
I
T
-
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
-
A
G
R
-
G
F
-
E
V
D
F
L
T
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
--
P
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
R
A
----------
T
----------
P
T
Y
L
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
L
T
T
-
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
R
R
-------
R
--
E
--
E
M
DDERVPL
E
P
I
---
M
F
---
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
E
A
E
--------
H
A
Q
W
Q
V
A
A
Q
D
L
R
S
R
L
L
A
G
L
----
A
S
T
--
S
F
Q
V
N
G
-
D
Q
----
D
H
V
V
P
H
I
L
N
L
S
F
E
D
V
--
D
A
E
A
F
L
V
T
L
-
K
-
D
L
V
A
V
A
T
G
S
A
S
T
S
A
-
S
-
F
T
P
S
H
V
L
R
A
M
-
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
--------------------------
77
HHSearch
63.70
34%
4
- C2 -
3A9Z
5
SCLY_RAT
A:
[18-428]
-
R
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
-
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
-
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
---
F
H
E
Q
Q
T
L
Q--------
T
-
R
-
P
-----
H
F
I
T
-
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
Q
-
V
A
-
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
----------
L
N
Q
I
R
A
A
S
GL
P
R
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
G
-------
V
--
G
--
K
L
-------
T
P
L
---
Y
P
MLF
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
--------
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
E
R
L
----
E
A
E
-
F
G
K
R
I
H
L
-
N
S
RFPG
V
E
R
L
P
N
T
C
N
F
S
I
Q
G
S
QL
R
G
Y
M
V
L
A
Q
---
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
-
H
E
D
R
P
S
P
V
L
L
S
C
-
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
------
31
PsiBlast_CBE
60.84
32%
13
- C2 -
3A9X
5
SCLY_RAT
B:
[19-428]
--
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
-
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
-
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
F
H
E
Q
-------
Q
---
T
---
L
Q---T
R
P
--
H
F
I
T
-
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
-
V
E
D
-
Q
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
G
L
P
----------
R
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
G
-------
V
--
G
--
K
L
-------
T
P
L
Y
P
M
L
F
---
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
E
R
L
E
A
E
F
G
K
R
I
HLNS
R
F
P
G
V
--------------
E
R
L
P
N
T
C
N
F
S
I
Q
G
S
--
Q
L
R
G
Y
M
V
L
A
-
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
-
D
R
P
S
P
V
L
L
S
C
-
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
------
12
PsiBlast_PDB
60.83
32%
10
- C2 -
3A9Z
5
SCLY_RAT
A:
[19-428]
--
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
-
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
-
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
F
H
E
Q
-------
Q
---
T
---
L
Q---T
R
P
--
H
F
I
T
-
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
-
V
E
D
-
Q
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
GL
P
----------
R
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
G
-------
V
--
G
--
K
L
-------
T
P
L
Y
P
M
L
F
---
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
E
R
L
E
A
E
F
G
K
R
I
HLNS
R
F
P
G
V
--------------
E
R
L
P
N
T
C
N
F
S
I
Q
G
S
--
Q
L
R
G
Y
M
V
L
A
-
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
-
D
R
P
S
P
V
L
L
S
C
-
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
------
11
PsiBlast_PDB
59.82
32%
26
- C2 -
3A9X
3
SCLY_RAT
A:
[19-428]
--
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
-
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
-
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
F
H
E
Q
-------
Q
---
T
---
L
Q
G
--EG
T
R
P
H
F
I
T
-
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
-
V
E
D
-
Q
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
G
L
P
----------
R
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
G
-------
V
--
G
--
K
L
-------
T
P
L
Y
P
M
L
F
---
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
E
R
L
E
A
E
F
G
K
R
I
HLNS
R
F
P
G
V
--------------
E
R
L
P
N
T
C
N
F
S
I
Q
G
S
--
Q
L
R
G
Y
M
V
L
A
-
Q
C
Q
T
L
L
A
S
V
G
A
---------------------
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
------
29
PsiBlast_CBE
59.13
32%
39
- C2 -
3A9Z
3
SCLY_RAT
B:
[19-428]
--
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
-
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
-
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
F
H
E
Q
--------------------T
R
P
--
H
F
I
T
-
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
-
V
E
D
-
Q
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
G
L
P
----------
R
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
G
-------
V
--
G
--
K
L
-------
T
P
L
Y
P
M
L
F
---
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
E
R
L
E
A
E
F
G
K
R
I
HLNS
R
F
P
G
V
--------------
E
R
L
P
N
T
C
N
F
S
I
Q
G
S
--
Q
L
R
G
Y
M
V
L
A
-
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
-
D
R
P
S
P
V
L
L
S
C
-
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
------
30
PsiBlast_CBE
58.70
32%
38
- C2 -
3A9Y
4
SCLY_RAT
B:
[19-428]
--
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
I
Q
A
V
T
E
A
M
K
--
E
A
W
G
N
P
S
S
-
S
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
-
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
F
H
E
Q
-------
Q
------------T
R
P
--
H
F
I
T
-
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
-
V
E
D
-
Q
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
G
L
P
----------
R
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
R
G
-------
V
--
G
--
K
L
-------
T
P
L
Y
P
M
L
F
---
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
E
R
L
E
A
E
F
G
K
R
I
HLNS
R
F
P
G
V
--------------
E
R
L
P
N
T
C
N
F
S
I
Q
G
S
--
Q
L
R
G
Y
M
V
L
A
-
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
-
D
R
P
S
P
V
L
L
S
C
-
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
------
32
PsiBlast_CBE
41.95
31%
-24
- C2 -
1T3I
3
CSD_SYNY3
B:
[30-259]
---
V
Y
L
D
N
A
A
T
S
Q
K
P
R
A
V
L
E
K
L
M
H
Y
Y
E
--
N
D
N
A
N
V
---
A
H
Q
L
S
V
R
A
T
D
A
Y
E
A
V
R
N
K
V
A
K
F
I
N
A
R
S
P
R
E
I
V
Y
T
R
N
A
T
E
A
I
N
L
V
A
Y
S
W
G
M
N
---
N
-------
L
---
K
---
A
-
G
-
D
-----
E
I
I
T
-
T
V
M
E
H
H
S
N
L
V
P
W
Q
M
V
-
A
A
K
T
G
A
-
V
L
K
F
V
Q
L
D
E
-
Q
E
S
F
D
L
E
H
F
K
T
L
L
S
--
E
K
T
K
L
V
T
V
V
H
I
S
N
T
L
G
C
V
N
P
A
E
E
I
A
Q
L
A
H
Q
----------
A
----------
G
A
K
V
L
V
D
A
C
Q
S
A
P
H
Y
P
L
D
V
Q
L
I
D
C
D
W
L
V
A
S
G
H
K
M
C
A
P
T
G
I
G
F
L
Y
G
K
E
-------
E
--
I
L
E
A
M
-------
P
P
F
---
F
G
---
G
G
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------