@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu28120: (2016-07-14 )
MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKGSKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLVIDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGVATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPPQEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPVGAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLEEGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGVFLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR
Atome Classification :
(49 SA)
.........10........20........30........40........50........60........70........80..--......90-.........100.......110..--.....120.......130..------.....140.......150.......160.......170..---..---...180.......190.......200.......210.......220.......230.......240....-...250.......260.......270.......280.....--..290.--.......-300.......310.....-.--.-320-.......330.......340.......350.......360.-......370.......380.......390.......400.......410.......420.......430
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRS
Y
E
K
S
K
T
A
F
K
E
A
Q
K
LMPGGVN
S
P
V
R
A
F
K
SVDMD
P
I
F
MERGKG
S
K
I
F
DIDG
N
E
Y
I
D
Y
V
LSWG
P
L
I
LGHT
N
D
R
V
V
E
S
L
K
K
V
A
E
--YGTSFGA--P
T
E
V
E
N
E
L
A
K
L
V
I
DRVP
S
V
E
I
V
R
M
--
V
SSG
T
E
A
T
M
S
A
L
R
L
ARGYTG------RN
K
I
L
K
F
E
G
C
YHGHG
D
S
L
L
I
KAGS
G
V
A
T
LGLPDSPGVPEG---IA---K
N
T
I
T
VPYN
D
L
E
S
V
K
L
A
F
Q
Q
F
G
E
D
I
A
G
V
I
VEPVAGNMGVVP
P
Q
E
G
F
L
Q
G
L
R
D
I
T
E
Q
YG
S
L
L
I
F
D
E
V
MTG
F
-
R
V
D
Y
NCAQGYFGVT
P
D
L
T
C
L
G
K
V
IGGGLPVGAYG
G
K
A
E
I
M
E
--
Q
IAP-S--GP
I
Y
Q
AG-TLSGN
P
L
A
M
T
A
G
L
E
T
L
K
Q
-L--
T
-
P
E
S
-
Y
K
N
F
I
KKG
D
R
L
E
E
G
I
S
KTAGAHGIPH
T
F
NRAG
S
M
I
G
F
F
FTN-E
P
V
I
N
Y
ETAKSS
D
L
K
L
F
A
S
Y
Y
KGMANE
G
V
FLPPSQFE
G
L
F
L
STAHT
D
E
D
I
E
N
T
I
Q
A
A
E
K
V
F
A
E
ISRR
1
PsiBlast_PDB
98.87
99%
-84
- C1 -
3BS8
1
GSA_BACSU
A:
[9-438]
M
R
S
Y
E
K
S
K
T
A
F
K
E
A
Q
K
L
M
P
G
G
V
N
S
P
V
R
A
F
K
S
V
D
M
D
P
I
F
M
E
R
G
K
G
S
K
I
F
D
I
D
G
N
E
Y
I
D
Y
V
L
S
W
G
P
L
I
L
G
H
T
N
D
R
V
V
E
S
L
K
K
V
A
E
--
Y
G
T
S
F
G
A
--
P
T
E
V
E
N
E
L
A
K
L
V
I
D
R
V
P
S
V
E
I
V
R
M
--
V
S
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
------
R
N
K
I
L
K
F
E
G
C
Y
H
G
H
G
D
S
L
L
I
K
A
G
S
G
V
A
T
L
G
L
P
D
S
P
G
V
P
E
G
---
I
A
---
K
N
T
I
T
V
P
Y
N
D
L
E
S
V
K
L
A
F
Q
Q
F
G
E
D
I
A
G
V
I
V
E
P
V
A
G
N
M
G
V
V
P
P
Q
E
G
F
L
Q
G
L
R
D
I
T
E
Q
Y
G
S
L
L
I
F
D
E
V
M
T
G
F
-
R
V
D
Y
N
C
A
Q
G
Y
F
G
V
T
P
D
L
T
C
L
G
K
V
I
G
G
G
L
P
V
G
A
Y
G
G
K
A
E
I
M
E
--
Q
I
A
P
-
S
--
G
P
I
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
L
E
T
L
K
Q
-
L
--
T
-
P
D
S
-
Y
K
N
F
I
K
K
G
D
R
L
E
E
G
I
S
K
A
A
E
A
H
G
I
P
H
T
F
N
R
A
G
S
M
I
G
F
F
F
T
N
-
E
P
V
I
N
Y
E
T
A
K
A
S
D
L
K
L
F
A
S
Y
Y
K
G
M
A
N
E
G
V
F
L
P
P
S
Q
F
E
G
L
F
L
S
T
A
H
T
D
E
D
I
E
N
T
I
Q
A
A
E
K
V
F
A
E
I
S
R
R
9
PsiBlast_PDB
82.38
58%
-76
- C1 -
2HOZ
3
GSA_SYNP6
A:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R
-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
13
PsiBlast_PDB
80.78
58%
-69
- C1 -
3FQ8
2
GSA_SYNP6
A:
[5-427]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R
-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
6
PsiBlast_PDB
80.77
58%
-70
- C1 -
3FQ7
2
GSA_SYNP6
A:
[5-427]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R
-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
12
PsiBlast_PDB
80.30
58%
-68
- C1 -
3FQA
3
GSA_SYNP6
A:
[5-427]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R
-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
10
PsiBlast_PDB
80.28
58%
-69
- C1 -
2HP1
3
GSA_SYNP6
A:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R
-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
25
PsiBlast_CBE
79.90
58%
-68
* C1 *
3FQ7
2
GSA_SYNP6
B:
[5-427]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
31
PsiBlast_CBE
79.78
58%
-69
- C1 -
3FQ8
2
GSA_SYNP6
B:
[5-427]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
4
PsiBlast_PDB
79.76
58%
-67
- C1 -
4GSA
2
GSA_SYNP6
A:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R
-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
125
Fugue
79.64
58%
-66
- C1 -
2GSA
2
GSA_SYNP6
A:
[6-432]
-
F
K
T
I
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
--
R
Q
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
23
PsiBlast_CBE
79.48
58%
-67
- C1 -
2GSA
2
GSA_SYNP6
B:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
7
PsiBlast_PDB
79.45
58%
-66
- C1 -
3USF
3
GSA_SYNE7
A:
[5-427]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R
-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
26
PsiBlast_CBE
79.23
58%
-66
- C1 -
2HP2
3
GSA_SYNP6
B:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
3
PsiBlast_PDB
79.16
58%
-67
- C1 -
2GSA
2
GSA_SYNP6
A:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R
-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
11
PsiBlast_PDB
79.14
58%
-70
- C1 -
2HP2
3
GSA_SYNP6
A:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R
-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
30
PsiBlast_CBE
79.13
58%
-67
- C1 -
3FQA
3
GSA_SYNP6
B:
[5-427]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
21
PsiBlast_CBE
79.06
58%
-66
- C1 -
4GSA
2
GSA_SYNP6
B:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
5
PsiBlast_PDB
78.88
58%
-69
- C1 -
3GSB
3
GSA_SYNP6
A:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R
-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
14
PsiBlast_PDB
78.78
54%
-69
- C1 -
5I92
2
?
A:
[11-434]
-----
R
S
E
T
L
F
N
N
A
Q
K
H
I
P
G
G
V
N
S
P
V
R
A
F
K
S
V
G
G
T
P
L
F
F
K
H
A
E
G
A
Y
V
L
D
E
D
D
K
R
Y
V
D
Y
V
G
S
W
G
P
M
I
L
G
H
S
H
P
D
V
L
D
A
V
R
R
Q
L
D
--
H
G
L
S
Y
G
A
--
P
T
A
L
E
V
E
M
A
D
L
V
C
S
M
V
P
S
M
E
M
V
R
M
--
V
S
S
G
T
E
A
T
M
S
A
I
R
L
A
R
G
Y
T
G
------
R
D
S
I
I
K
F
E
G
C
Y
H
G
H
S
D
S
L
L
V
K
A
G
S
---
T
F
G
V
P
N
S
P
G
V
P
A
A
---
F
A
---
K
H
T
L
T
L
P
F
N
D
I
E
A
V
R
K
T
L
G
E
V
G
K
E
V
A
C
I
I
V
E
P
V
A
G
N
M
N
C
V
P
P
A
P
G
F
L
E
G
L
R
E
A
C
D
E
H
G
V
V
L
I
F
D
E
V
M
T
G
F
-
R
V
A
L
G
G
A
Q
A
Y
Y
G
V
T
P
D
L
S
T
F
G
K
I
I
G
G
G
M
P
V
G
A
F
G
G
K
R
E
I
M
Q
--
Q
I
S
P
-
L
--
G
P
V
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
A
A
G
L
T
T
L
R
L
-
I
--
S
R
P
G
F
-
H
D
E
L
T
A
Y
T
T
R
M
L
D
G
L
Q
Q
R
A
D
A
A
G
I
P
F
V
T
T
Q
A
G
G
M
F
G
L
Y
F
S
G
A
D
A
I
V
T
F
E
D
V
M
A
S
D
V
E
R
F
K
R
F
F
H
L
M
L
D
G
G
V
Y
L
A
P
S
A
F
E
A
G
F
T
S
I
A
H
G
D
K
E
L
E
I
T
L
N
A
A
E
K
A
F
A
A
L
---
29
PsiBlast_CBE
78.57
58%
-78
- C1 -
2HOY
2
GSA_SYNP6
B:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
----------------------------------------
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R
-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
28
PsiBlast_CBE
78.56
58%
-73
- C1 -
2HOZ
2
GSA_SYNP6
B:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
-------
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R
-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
22
PsiBlast_CBE
77.98
58%
-67
- C1 -
3GSB
3
GSA_SYNP6
B:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
24
PsiBlast_CBE
77.07
58%
-77
- C1 -
3USF
3
GSA_SYNE7
B:
[5-427]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
----------------------------
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R
-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
27
PsiBlast_CBE
76.29
58%
-77
- C1 -
2HP1
3
GSA_SYNP6
B:
[10-432]
-----
K
S
D
E
I
F
A
A
A
Q
K
L
M
P
G
G
V
S
S
P
V
R
A
F
K
S
V
G
G
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
-----------------------------------
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
-
L
R
-
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
L
---
120
HHSearch
74.62
57%
-73
- C1 -
3FQ8
2
GSA_SYNP6
A:
[34-426]
----------------------------------
Q
P
I
V
F
D
R
V
K
D
A
Y
A
W
D
V
D
G
N
R
Y
I
D
Y
V
G
T
W
G
P
A
I
C
G
H
A
H
P
E
V
I
E
A
L
K
V
A
M
E
--
K
G
T
S
F
G
A
--
P
C
A
L
E
N
V
L
A
E
M
V
N
D
A
V
P
S
I
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
I
M
R
A
Y
T
G
------
R
D
K
I
I
K
F
E
G
C
Y
H
G
H
A
D
M
F
L
V
K
A
G
S
G
V
A
T
L
G
L
P
S
S
P
G
V
P
K
K
---
T
T
---
A
N
T
L
T
T
P
Y
N
D
L
E
A
V
K
A
L
F
A
E
N
P
G
E
I
A
G
V
I
L
E
P
I
V
G
N
S
G
F
I
V
P
D
A
G
F
L
E
G
L
R
E
I
T
L
E
H
D
A
L
L
V
F
D
E
V
I
T
G
F
-
R
I
A
Y
G
G
V
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
I
I
G
G
G
L
P
V
G
A
Y
G
G
K
R
E
I
M
Q
--
L
V
A
P
-
A
--
G
P
M
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
L
L
R
--
Q
-
P
G
T
-
Y
E
Y
L
D
Q
I
T
K
R
L
S
D
G
L
L
A
I
A
Q
E
T
G
H
A
A
C
G
G
Q
V
S
G
M
F
G
F
F
F
T
E
-
G
P
V
H
N
Y
E
D
A
K
K
S
D
L
Q
K
F
S
R
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
E
D
I
D
A
T
L
A
A
A
R
T
V
M
S
A
----
2
PsiBlast_PDB
73.20
60%
-87
- C1 -
2CFB
1
GSA_THEEB
A:
[19-411]
-----------------------------------
P
I
V
F
D
H
V
K
G
A
H
I
W
D
V
D
G
N
Q
Y
I
D
Y
V
G
S
W
G
P
A
I
V
G
H
A
H
P
E
V
I
D
A
L
H
A
A
L
E
--
K
G
T
S
F
G
A
--
P
C
L
L
E
N
I
L
A
E
M
V
I
A
A
V
P
S
V
E
M
V
R
F
--
V
N
S
G
T
E
A
C
M
A
V
L
R
L
M
R
A
Y
T
Q
------
R
E
K
V
I
K
F
E
G
C
Y
H
G
H
A
----------------------------------
A
T
L
T
A
P
Y
N
D
L
E
A
V
S
R
L
F
E
Q
Y
P
N
D
I
A
G
V
I
L
E
P
V
V
G
N
A
G
F
I
P
P
D
A
G
F
L
E
G
L
R
E
L
T
K
Q
Y
G
A
L
L
V
F
D
E
V
M
T
G
F
-
R
I
A
Y
G
G
A
Q
E
K
F
G
V
T
P
D
L
T
T
L
G
K
V
I
G
G
G
L
P
V
G
A
Y
G
G
R
A
E
I
M
K
--
M
V
A
P
-
A
--
G
P
------
T
L
S
G
N
P
L
A
M
T
A
G
I
K
T
L
E
I
-
L
--
S
R
P
G
S
-
Y
E
H
L
D
R
I
T
G
K
L
V
Q
G
L
L
D
A
A
R
E
F
G
H
E
V
C
G
G
H
I
S
G
M
F
G
L
F
F
T
A
-
G
P
V
T
N
Y
E
Q
A
K
Q
S
D
L
K
K
F
A
A
F
H
R
G
M
L
E
Q
G
I
Y
L
A
P
S
Q
F
E
A
G
F
T
S
L
A
H
T
E
A
D
I
E
R
T
I
A
A
A
R
T
V
L
S
Q
L
---
15
PsiBlast_PDB
71.90
52%
-54
- C1 -
2E7U
4
GSA_THET8
A:
[6-424]
------
S
E
A
Y
F
Q
E
A
K
R
H
I
P
G
G
V
S
S
P
V
R
A
F
K
A
V
G
G
T
P
P
F
L
V
R
G
E
G
A
Y
V
W
D
A
D
G
N
R
Y
L
D
Y
V
M
S
W
G
P
L
I
L
G
H
A
H
P
K
V
L
A
R
V
R
E
T
L
E
--
R
G
L
T
F
G
A
--
P
S
P
L
E
V
A
L
A
K
K
V
K
R
A
Y
P
F
V
D
L
V
R
F
--
V
N
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
------
R
P
Y
I
V
K
F
R
G
N
Y
H
G
H
A
D
G
L
L
V
E
A
G
S
G
A
L
T
L
G
V
P
S
S
A
G
V
P
E
E
---
Y
A
---
K
L
T
L
V
L
E
Y
N
D
P
E
G
L
R
E
V
L
K
R
R
G
E
E
I
A
A
I
I
F
E
P
V
V
G
N
A
G
V
L
V
P
T
E
D
F
L
K
A
L
H
E
-
A
K
A
Y
G
V
L
L
I
A
D
E
V
M
T
G
F
-
R
L
A
F
G
G
A
T
E
L
L
G
L
K
P
D
L
V
T
L
G
K
I
L
G
G
G
L
P
A
A
A
Y
A
G
R
R
E
I
M
E
--
K
V
A
P
-
L
--
G
P
V
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
A
A
G
L
A
T
L
E
L
-
L
E
E
N
-
P
G
Y
-
Y
A
Y
L
E
D
L
G
A
R
L
E
A
G
L
K
E
V
L
K
E
K
G
L
P
H
T
V
N
R
V
G
S
M
I
T
V
F
F
T
E
-
G
P
V
V
T
F
Q
D
A
R
R
T
D
T
E
L
F
K
R
F
F
H
G
L
L
D
R
G
I
Y
W
P
P
S
N
F
E
A
A
F
L
S
V
A
H
R
E
E
D
V
E
K
T
L
E
A
L
R
K
A
L
------
34
PsiBlast_CBE
71.21
44%
-80
- C1 -
2ZSM
4
GSA_AERPE
B:
[10-422]
----
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
--
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
--
R
G
W
L
Y
G
A
--
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
--
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
---
V
A
---
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
--
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
-
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
-
L
--
E
-
E
E
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
Y
T
I
N
R
V
E
S
M
M
Q
L
F
I
G
V
-
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
------------
16
PsiBlast_PDB
70.42
44%
-77
- C1 -
2EPJ
1
GSA_AERPE
A:
[9-422]
---
G
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
--
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
--
R
G
W
L
Y
G
A
--
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
--
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
---
V
A
---
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
--
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
-
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
-
L
--
E
-
E
E
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
Y
T
I
N
R
V
E
S
M
M
Q
L
F
I
G
V
-
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
------------
17
PsiBlast_PDB
70.22
44%
-77
- C1 -
2ZSL
1
GSA_AERPE
A:
[9-422]
---
G
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
--
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
--
R
G
W
L
Y
G
A
--
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
--
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
---
V
A
---
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
--
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
-
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
-
L
--
E
-
E
E
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
Y
T
I
N
R
V
E
S
M
M
Q
L
F
I
G
V
-
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
------------
33
PsiBlast_CBE
70.05
44%
-77
- C1 -
2ZSM
4
GSA_AERPE
C:
[10-422]
----
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
--
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
--
R
G
W
L
Y
G
A
--
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
--
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
---
V
A
---
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
--
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
-
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
-
L
--
E
-
E
E
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
Y
T
I
N
R
V
E
S
M
M
Q
L
F
I
G
V
-
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
------------
18
PsiBlast_PDB
70.02
44%
-74
- C1 -
2ZSM
2
GSA_AERPE
A:
[6-422]
L
A
S
G
E
K
S
R
M
L
F
E
R
T
K
E
L
F
P
G
G
V
N
S
P
V
R
A
--
A
V
K
P
Y
P
F
Y
V
K
R
G
E
G
A
Y
L
Y
T
V
D
G
A
R
I
V
D
L
V
L
A
Y
G
P
L
I
L
G
H
K
H
P
R
V
L
E
A
V
E
E
A
L
A
--
R
G
W
L
Y
G
A
--
P
G
E
A
E
V
L
L
A
E
K
I
L
G
Y
V
K
R
G
G
M
I
R
F
--
V
N
S
G
T
E
A
T
M
T
A
I
R
L
A
R
G
Y
T
G
------
R
D
L
I
L
K
F
D
G
C
Y
H
G
S
H
D
A
V
L
V
A
A
G
------
G
V
P
T
S
A
G
V
P
E
A
---
V
A
---
R
L
T
L
V
T
P
Y
N
D
V
E
A
L
E
R
V
F
A
E
Y
G
D
R
I
A
G
V
I
V
E
P
V
I
A
N
A
G
V
I
P
P
R
R
E
F
L
A
A
L
Q
R
L
S
R
E
S
G
A
L
L
I
L
D
E
V
V
T
G
F
-
R
L
G
L
E
G
A
Q
G
Y
F
N
I
E
G
D
I
I
V
L
G
K
I
I
G
G
G
F
P
V
G
A
V
A
G
S
R
E
V
M
S
--
L
L
T
P
-
Q
--
G
K
V
F
N
A
G
-
T
F
N
A
H
P
I
T
M
A
A
G
L
A
T
L
K
A
-
L
--
E
-
E
E
P
V
Y
S
V
S
R
E
A
A
K
A
L
E
E
A
A
S
E
V
L
D
R
T
G
L
P
Y
T
I
N
R
V
E
S
M
M
Q
L
F
I
G
V
-
E
E
V
S
N
A
A
Q
A
R
K
A
D
K
K
F
Y
V
K
L
H
E
E
M
L
R
R
G
V
F
I
A
P
S
N
L
E
A
V
F
T
G
L
P
H
Q
G
E
A
L
E
I
A
V
E
------------
45
PsiBlast_CBE
64.78
31%
-65
- C1 -
4AO9
3
BFAT_VARPD
B:
[44-438]
------
S
Q
R
Q
F
E
A
Q
A
R
Y
M
P
G
A
N
S
R
S
V
L
F
Y
A
P
F
---
P
L
T
I
A
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
M
Q
--
G
G
I
N
L
T
G
--
H
N
L
L
E
G
R
L
A
R
L
I
C
E
R
F
P
Q
I
E
Q
L
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
------
R
R
K
I
V
V
F
S
G
G
Y
H
G
-------------
G
V
L
G
F
G
A
R
P
S
-
P
T
T
---
V
P
---
F
D
F
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
R
-
L
A
P
H
G
L
A
N
-
K
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
--
L
F
D
P
R
T
--
G
P
L
A
H
S
G
-
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
-
L
F-
T
-
P
E
A
-
A
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
M
Q
F
T
G
I
G
S
L
M
N
A
H
F
V
Q
-
G
D
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
--
V
V
L
S
L
P
L
T
D
A
D
I
D
R
Y
V
A
A
-----------
117
HHSearch
64.25
52%
-53
- C1 -
2E7U
4
GSA_THET8
A:
[34-424]
----------------------------------
T
P
P
F
L
V
R
G
E
G
A
Y
V
W
D
A
D
G
N
R
Y
L
D
Y
V
M
S
W
G
P
L
I
L
G
H
A
H
P
K
V
L
A
R
V
R
E
T
L
E
--
R
G
L
T
F
G
A
--
P
S
P
L
E
V
A
L
A
K
K
V
K
R
A
Y
P
F
V
D
L
V
R
F
--
V
N
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
------
R
P
Y
I
V
K
F
R
G
N
Y
H
G
H
A
D
G
L
L
V
E
A
G
S
G
A
L
T
L
G
V
P
S
S
A
G
V
P
E
E
---
Y
A
---
K
L
T
L
V
L
E
Y
N
D
P
E
G
L
R
E
V
L
K
R
R
G
E
E
I
A
A
I
I
F
E
P
V
V
G
N
A
G
V
L
V
P
-
T
E
D
F
L
K
A
L
H
E
A
K
A
Y
G
V
L
L
I
A
D
E
V
M
T
G
F
-
R
L
A
F
G
G
A
T
E
L
L
G
L
K
P
D
L
V
T
L
G
K
I
L
G
G
G
L
P
A
A
A
Y
A
G
R
R
E
I
M
E
--
K
V
A
P
-
L
--
G
P
V
Y
Q
A
G
-
T
L
S
G
N
P
L
A
M
A
A
G
L
A
T
L
E
L
L
E
--
E
N
P
G
Y
-
Y
A
Y
L
E
D
L
G
A
R
L
E
A
G
L
K
E
V
L
K
E
K
G
L
P
H
T
V
N
R
V
G
S
M
I
T
V
F
F
T
E
-
G
P
V
V
T
F
Q
D
A
R
R
T
D
T
E
L
F
K
R
F
F
H
G
L
L
D
R
G
I
Y
W
P
P
S
N
F
E
A
A
F
L
S
V
A
H
R
E
E
D
V
E
K
T
L
E
A
L
R
K
A
L
------
46
PsiBlast_CBE
64.24
31%
-63
- C1 -
4AO9
2
BFAT_VARPD
A:
[44-438]
------
S
Q
R
Q
F
E
A
Q
A
R
Y
M
P
G
A
N
S
R
S
V
L
F
Y
A
P
F
---
P
L
T
I
A
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
M
Q
--
G
G
I
N
L
T
G
--
H
N
L
L
E
G
R
L
A
R
L
I
C
E
R
F
P
Q
I
E
Q
L
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
------
R
R
K
I
V
V
F
S
G
G
Y
H
G
-------------
G
V
L
G
F
G
A
R
P
S
-
P
T
T
---
V
P
---
F
D
F
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
R
-
L
A
P
H
G
L
A
N
-
K
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
--
L
F
D
P
R
T
--
G
P
L
A
H
S
G
-
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
-
L
F-
T
-
P
E
A
-
A
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
M
Q
F
T
G
I
G
S
L
M
N
A
H
F
V
Q
-
G
D
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
--
V
V
L
S
L
P
L
T
D
A
D
I
D
R
Y
V
A
A
-----------
44
PsiBlast_CBE
63.30
31%
-62
- C1 -
4AOA
3
BFAT_VARPD
A:
[44-438]
------
S
Q
R
Q
F
E
A
Q
A
R
Y
M
P
G
A
N
S
R
S
V
L
F
Y
A
P
F
---
P
L
T
I
A
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
M
Q
--
G
G
I
N
L
T
G
--
H
N
L
L
E
G
R
L
A
R
L
I
C
E
R
F
P
Q
I
E
Q
L
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
------
R
R
K
I
V
V
F
S
G
G
Y
H
G
-------------
G
V
L
G
F
G
A
R
P
S
-
P
T
T
---
V
P
---
F
D
F
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
R
-
L
A
P
H
G
L
A
N
-
K
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
--
L
F
D
P
R
T
--
G
P
L
A
H
S
G
-
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
-
L
F-
T
-
P
E
A
-
A
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
M
Q
F
T
G
I
G
S
L
M
N
A
H
F
V
Q
-
G
D
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
--
V
V
L
S
L
P
L
T
D
A
D
I
D
R
Y
V
A
A
-----------
43
PsiBlast_CBE
63.30
31%
-64
- C1 -
4AOA
2
BFAT_VARPD
B:
[44-438]
------
S
Q
R
Q
F
E
A
Q
A
R
Y
M
P
G
A
N
S
R
S
V
L
F
Y
A
P
F
---
P
L
T
I
A
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
M
Q
--
G
G
I
N
L
T
G
--
H
N
L
L
E
G
R
L
A
R
L
I
C
E
R
F
P
Q
I
E
Q
L
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
------
R
R
K
I
V
V
F
S
G
G
Y
H
G
-------------
G
V
L
G
F
G
A
R
P
S
-
P
T
T
---
V
P
---
F
D
F
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
R
-
L
A
P
H
G
L
A
N
-
K
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
--
L
F
D
P
R
T
--
G
P
L
A
H
S
G
-
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
-
L
F-
T
-
P
E
A
-
A
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
M
Q
F
T
G
I
G
S
L
M
N
A
H
F
V
Q
-
G
D
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
--
V
V
L
S
L
P
L
T
D
A
D
I
D
R
Y
V
A
A
-----------
53
PsiBlast_CBE
63.29
32%
-70
- C1 -
2YKX
6
?
C:
[62-447]
-----------
E
R
A
R
R
S
M
P
G
G
N
T
R
S
I
L
F
H
R
P
F
---
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
--
V
G
L
N
L
S
T
--
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
----------
P
T
N
---
A
P
---
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
-
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
-
I
Y-
T
-
R
Q
A
-
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
L
Q
F
T
G
L
G
S
L
G
T
I
H
F
S
R
-
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
------------------
50
PsiBlast_CBE
62.78
32%
-69
- C1 -
2YKY
11
?
C:
[62-447]
-----------
E
R
A
R
R
S
M
P
G
G
N
T
R
S
I
L
F
H
R
P
F
---
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
--
V
G
L
N
L
S
T
--
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
----------
P
T
N
---
A
P
---
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
-
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
-
I
Y-
T
-
R
Q
A
-
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
L
Q
F
T
G
L
G
S
L
G
T
I
H
F
S
R
-
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
------------------
55
PsiBlast_CBE
62.75
32%
-71
- C1 -
2YKX
8
?
A:
[62-447]
-----------
E
R
A
R
R
S
M
P
G
G
N
T
R
S
I
L
F
H
R
P
F
---
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
--
V
G
L
N
L
S
T
--
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
----------
P
T
N
---
A
P
---
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
-
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
-
I
Y-
T
-
R
Q
A
-
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
L
Q
F
T
G
L
G
S
L
G
T
I
H
F
S
R
-
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
------------------
52
PsiBlast_CBE
62.34
32%
-69
- C1 -
2YKY
11
?
A:
[62-447]
-----------
E
R
A
R
R
S
M
P
G
G
N
T
R
S
I
L
F
H
R
P
F
---
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
--
V
G
L
N
L
S
T
--
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
----------
P
T
N
---
A
P
---
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
-
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
-
I
Y-
T
-
R
Q
A
-
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
L
Q
F
T
G
L
G
S
L
G
T
I
H
F
S
R
-
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
------------------
54
PsiBlast_CBE
61.63
32%
-69
- C1 -
2YKX
5
?
B:
[62-447]
-----------
E
R
A
R
R
S
M
P
G
G
N
T
R
S
I
L
F
H
R
P
F
---
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
--
V
G
L
N
L
S
T
--
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
----------
P
T
N
---
A
P
---
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
-
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
-
I
Y-
T
-
R
Q
A
-
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
L
Q
F
T
G
L
G
S
L
G
T
I
H
F
S
R
-
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
------------------
61
PsiBlast_CBE
61.59
32%
-69
- C1 -
2YKU
9
?
A:
[62-447]
-----------
E
R
A
R
R
S
M
P
G
G
N
T
R
S
I
L
F
H
R
P
F
---
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
--
V
G
L
N
L
S
T
--
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
----------
P
T
N
---
A
P
---
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
-
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
-
I
Y-
T
-
R
Q
A
-
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
L
Q
F
T
G
L
G
S
L
G
T
I
H
F
S
R
-
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
------------------
59
PsiBlast_CBE
61.57
32%
-70
- C1 -
2YKU
6
?
C:
[62-447]
-----------
E
R
A
R
R
S
M
P
G
G
N
T
R
S
I
L
F
H
R
P
F
---
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
--
V
G
L
N
L
S
T
--
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
----------
P
T
N
---
A
P
---
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
-
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
-
I
Y-
T
-
R
Q
A
-
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
L
Q
F
T
G
L
G
S
L
G
T
I
H
F
S
R
-
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
------------------
51
PsiBlast_CBE
60.92
32%
-69
- C1 -
2YKY
16
?
B:
[62-447]
-----------
E
R
A
R
R
S
M
P
G
G
N
T
R
S
I
L
F
H
R
P
F
---
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
--
V
G
L
N
L
S
T
--
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
----------
P
T
N
---
A
P
---
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
-
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
-
I
Y-
T
-
R
Q
A
-
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
L
Q
F
T
G
L
G
S
L
G
T
I
H
F
S
R
-
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
------------------
60
PsiBlast_CBE
60.56
32%
-68
- C1 -
2YKU
10
?
B:
[62-447]
-----------
E
R
A
R
R
S
M
P
G
G
N
T
R
S
I
L
F
H
R
P
F
---
P
L
V
I
A
Q
G
T
G
S
R
F
Q
D
V
D
G
H
A
Y
V
N
F
L
G
E
Y
T
A
G
L
F
G
H
S
H
P
V
I
R
A
A
V
E
R
A
L
A
--
V
G
L
N
L
S
T
--
Q
T
E
N
E
A
L
F
A
E
A
V
C
D
R
F
P
S
I
D
L
V
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
A
T
A
T
A
I
T
G
------
R
K
T
V
L
A
F
D
G
G
Y
H
G
G
----
L
L
N
F
A
S
G
H
A
----------
P
T
N
---
A
P
---
Y
H
V
V
L
G
V
Y
N
D
V
E
G
T
A
D
L
L
K
R
H
G
H
D
C
A
A
I
L
V
E
P
M
L
G
A
G
G
C
V
P
A
E
R
A
F
L
D
L
L
R
A
E
A
S
R
C
G
A
L
L
I
F
D
E
V
M
T
S
--
R
L
S
G
G
G
A
Q
E
M
L
G
I
S
A
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
R
D
L
M
E
--
R
F
D
P
-
A
RD
G
A
F
A
H
A
G
-
T
F
N
N
N
I
L
T
M
S
A
G
H
A
A
L
T
Q
-
I
Y-
T
-
R
Q
A
-
A
S
D
L
S
A
S
G
D
R
F
R
A
N
L
N
R
I
A
V
E
N
Q
A
P
L
Q
F
T
G
L
G
S
L
G
T
I
H
F
S
R
-
A
P
I
R
S
A
G
D
V
R
A
A
D
Q
Q
L
K
E
L
F
F
F
H
M
L
R
K
G
I
Y
L
A
P
R
G
M
Y
A
L
S
L
E
I
A
D
A
G
R
D
------------------
110
HHSearch
59.45
31%
-62
- C1 -
4AO9
2
BFAT_VARPD
A:
[69-448]
----------------------------------
F
P
L
T
I
A
R
G
E
G
A
A
L
W
D
A
D
G
H
R
Y
A
D
F
I
A
E
Y
T
A
G
V
Y
G
H
S
A
P
E
I
R
D
A
V
I
E
A
M
Q
--
G
G
I
N
L
T
G
--
H
N
L
L
E
G
R
L
A
R
L
I
C
E
R
F
P
Q
I
E
Q
L
R
F
--
T
N
S
G
T
E
A
N
L
M
A
L
T
A
A
L
H
F
T
G
------
R
R
K
I
V
V
F
S
G
G
Y
H
G
G
V
L
G
F
G
A
R
P
S
P
----------
T
T
-------
V
P
---
F
D
F
L
V
L
P
Y
N
D
A
Q
T
A
R
A
Q
I
E
R
H
G
P
E
I
A
V
V
L
V
E
P
M
Q
G
A
S
G
C
I
P
G
Q
P
D
F
L
Q
A
L
R
E
S
A
T
Q
V
G
A
L
L
V
F
D
E
V
M
T
S
R
--
L
A
P
H
G
L
A
N
K
L
G
I
R
S
D
L
T
T
L
G
K
Y
I
G
G
G
M
S
F
G
A
F
G
G
R
A
D
V
M
A
--
L
F
D
P
R
T
--
G
P
L
A
H
S
G
-
T
F
N
N
N
V
M
T
M
A
A
G
Y
A
G
L
T
K
L
F
--
T
-
P
E
A
-
A
G
A
L
A
E
R
G
E
A
L
R
A
R
L
N
A
L
C
A
N
E
G
V
A
M
Q
F
T
G
I
G
S
L
M
N
A
H
F
V
Q
-
G
D
V
R
S
S
E
D
L
A
A
V
D
G
R
L
R
Q
L
L
F
F
H
L
L
N
E
D
I
Y
S
S
P
R
G
F
V
V
L
S
--
L
P
L
T
D
A
D
I
D
R
Y
V
A
A
I
G
S
F
I
G
G
H
G
A
-
90
PsiBlast_CBE
27.87
32%
3
- C1 -
4JF1
9
ARGD_SALTY
B:
[36-329]
----------------------------
Y
A
P
A
D
F
I
P
V
---
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
T
S
N
V
F
--
T
N
E
P
A
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
R
V
L
F
--
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPF
K
T
K
I
I
A
F
H
N
A
F
H
G
--
Q
S
L
F
--------
T
V
S
V
G
G
Q
P
K
Y
S
D
G
---
F
G
PKP
A
D
I
I
H
V
P
F
N
D
L
H
A
V
K
A
V
M
D
---
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
V
G
S
-
H
--
G
S
T
Y
------
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
-
I
N
-
T
-
P
E
V
-
L
Q
G
I
H
T
K
------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
27.45
35%
10
- C1 -
1VEF
2
ARGD_THET8
B:
[9-301]
------
W
R
-
A
L
L
E
A
E
K
T
L
D
S
G
V
------
Y
N
K
H
D
L
---
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
--
T
L
M
A
M
P
Q
TL
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
-
E
L
N
R
V
FP
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
G
------
R
K
K
---
F
V
A
A
M
R
G
F
-------
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
R
E
P
FLP
L
V
---
E
P
V
E
F
I
P
Y
N
D
V
E
A
L
K
R
A
V
D
---
E
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
V
P
L
G
V
----
A
V
M
R
E
--
E
V
A
R
-
S
--
M
P
K
G
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
-
L
---------------------------------------------------------------------------------------------------------------------