@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu28260: (2016-07-14 )
MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEGLRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHSVDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQQRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMTVCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKSIVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKIEDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLDQIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMAAMAAIHGHFVDVRKFYQEKTVV
Atome Classification :
(20 SA)
-------------------------------....-.....10....-..-.----.-20-...------...--..30........40.......---.-50.-......------.60......--.----.70-------....---....80........90-...-----------..-..-..100.......110..---------.---------....120.......130.......140.......150.......160.......170.......180.....----..--190------....--...200.......210.......220.......230...-.-...240.-------...----------...--250--.---------.......--.260.-......270.......280..-.-....290..-------.....300.......310-------..-.....-------320.......330.......340.......350.......360------.------..---.---...370.----......380.......390.......400.......410.---..--..-..420------.--.---.--...---...430.....--.--.440..--..--....450.......-----460.......470--------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------MM
P
R
-
T
I
I
E
K
I
W
D
Q
H
I
-
V
K
-H----G-EG-KP
D
------
L
L
Y
--
I
D
L
H
L
I
H
EVT
S
P
Q
A
F
E
G
L
R
Q
K---
G
-
R
KV-RRPQN
T
------
F
ATMDHNIP--T----V
N
R
-------
F
E
I
K
---
D
E
V
A
K
R
Q
V
T
A
L
E
R
N
C
--
E
E
F
-----------
G
V
-
R
L
-
A
D
L
H
S
VDQG
I
V
H
VVGPE---------L---------GLTLPG
K
T
I
V
CGDSHTSTHGA
F
G
A
L
A
FGI
G
T
S
E
V
E
H
V
L
S
T
Q
T
L
W
Q
QRP
K
T
L
E
V
R
VDGTLQKGV
T
A
K
D
V
I
L
A
V
----
I
G
--KYG------VKFG--T
G
Y
V
I
E
Y
T
G
E
V
F
RNM
T
M
D
E
R
M
T
V
C
N
M
S
IEAGARAGLIAP-
D
-
E
V
T
F
E
Y
C
-------KNR----------KYT--P----K---------
G
E
E
F
D
K
A
--
V
E
E
W
K
-
A
LRTDPGAV
Y
D
K
S
I
V
LDGNKI-
S
-
P
M
V
T
WGINP-------
G
M
V
L
PVDSEVPAPESFSA-------E
D
-
D
K
K
E
A
-------
I
R
A
Y
E
YMGLTPHQKIE
D
I
K
V
E
H
V
F
I
GSCTN
S
R
M
T
D
L
R
Q
A
A
D
M
I------K------G
K
---
K
---
V
A
DS
V
R
A
----
I
V
VPGS
Q
S
V
K
L
Q
A
E
KE
G
L
D
Q
I
F
L
E
AG
F
E
W
R
E
SG
C
S
M
C
L
SM---NN--DV-VPE--------
G
--
E
---R--CAS---TSNRNFEGRQG--K--GAR-
T
H
--LV--
S
P
A
M
A
A
M
A
A
I
H
G
H
F
-----
V
D
V
R
K
F
Y
Q
EKTVV--------------------------------
34
HHSearch
77.17
37%
6
- C4 -
4KP1
6
LEUC_METJA
A:
[23-445]
---------------------------------
G
M
-
T
I
V
E
K
I
L
A
K
A
S
-
G
K
-
K
E---
V
S
P
G
-
D
I
V
------
M
A
N
--
I
D
V
A
M
V
H
D
I
T
G
P
L
T
V
N
T
L
K
E
Y
G--
I
-
E
K
V
-
W
N
P
E
K
I
------
V
I
L
F
D
H
Q
V
P
--
A
----
D
S
I
-------
K
--------
A
A
E
N
H
-
I
L
M
R
K
F
V
--
K
E
Q
-----------
G
I
K
Y
F
-
Y
D
I
R
---
E
G
V
C
H
Q
V
L
P
E
---------
K
---------
G
H
V
A
P
G
E
V
V
V
G
A
D
S
H
T
C
T
H
G
A
F
G
A
F
A
T
G
I
G
S
T
D
M
A
H
V
F
A
T
G
K
L
W
F
K
V
P
E
T
I
Y
F
N
I
T
G
D
L
Q
P
Y
V
T
S
K
D
V
I
L
S
I
----
I
G
--
E
V
G
------
V
D
G
A
--
T
Y
K
A
C
Q
F
G
G
E
T
V
K
K
M
S
I
A
S
R
M
T
M
T
N
M
A
I
E
M
G
G
K
T
G
I
I
E
P
-
D
-
E
K
T
I
Q
Y
V
-------
K
E
A
----------
M
K
K
--
H
----
G
---------------
T
--
E
R
P
F
E
-
V
I
K
G
D
E
D
A
E
F
A
E
V
Y
E
I
E
A
D
K
I
-
E
-
P
V
F
A
C
P
H
N
V
-------
D
N
----------------------------------------------
V
K
Q
A
R
E
V
A
G
K
P
I
D
Q
V
F
I
G
S
C
T
N
G
R
L
E
D
L
R
M
A
I
K
I
I
------
E
------
K
H
G--
G
---
I
A
D
D
V
R
V
----
V
V
T
P
A
S
R
E
E
Y
L
K
A
L
K
E
G
I
I
E
K
F
L
K
Y
G
C
V
V
T
N
P
S
C
S
A
C
M
G
S
---
L
Y
--
G
V
-
L
G
P
--------
G
--
E
---
V
--
C
V
S
---
T
S
N
R
N
F
R
G
R
Q
G
S-
L
--
E
A
E
-
I
Y
--
L
A
--
S
P
I
T
A
A
A
C
A
V
K
G
E
L
-----
V
D
P
R
D
L
---------------------------------------
3
PsiBlast_PDB
74.47
33%
10
- C4 -
4KP1
6
LEUC_METJA
A:
[25-445]
------------------------------------
T
I
V
E
K
I
L
A
K
A
S
-
G
K
-
K
----
E
-
V
S
-
P
G
D
------
I
V
M
A
N
I
D
V
A
M
V
H
D
I
T
G
P
L
T
V
N
T
L
K
E
Y
---
G
I
E
K
V
-
W
N
P
E
K
I
------
V
I
L
F
D
H
Q
V
P
--
A
----
D
S
I
-------
K
A
A
E
---
N
H
I
L
M
R
K
F
V
--------
K
E
Q
-----------
G
I
-
K
Y
---
F
Y
D
I
R
E
G
V
C
H
Q
V
L
P
E
---------
K
---------
G
H
V
A
P
G
E
V
V
V
G
A
D
S
H
T
C
T
H
G
A
F
G
A
F
A
T
G
I
G
S
T
D
M
A
H
V
F
A
T
G
K
L
W
F
K
V
P
E
T
I
Y
F
N
I
T
G
D
L
Q
P
Y
V
T
S
K
D
V
I
L
S
I
----
I
G
--
E
V
G
------
V
D
G
A
--
T
Y
K
A
C
Q
F
G
G
E
T
V
K
K
M
S
I
A
S
R
M
T
M
T
N
M
A
I
E
M
G
G
K
T
G
I
I
E
P
-
D
-
E
K
T
I
Q
Y
V
-------
K
E
A
----------
M
K
K
--
H
----
G
---------
T
E
--------
R
P
F
E
-
V
I
K
G
D
E
D
A
E
F
A
E
V
Y
E
I
E
A
D
K
I
-
E
-
P
V
-----------------------------
F
A
C
-------
P
H
-
N
V
D
N
V
-------
K
Q
A
R
E
V
A
G
K
---------
P
I
D
Q
V
F
I
G
S
C
T
N
G
R
L
E
D
L
R
M
A
I
K
I
I
E
-----
K
------
H
G
---
G
---
I
A
D
D
V
R
V
----
V
V
T
P
A
S
R
E
E
Y
L
K
A
L
K
E
G
I
I
E
K
F
L
K
Y
G
C
V
V
T
N
P
S
C
S
A
C
M
G
S
---
L
Y
--
G
V
-
L
G
P
--------
G
--
E
---
V
--
C
V
S
---
T
S
N
R
N
F
R
G
R
Q
G
--
S
L-
E
A
E
-
I
Y
--
L
A
--
S
P
I
T
A
A
A
C
A
V
K
G
E
L
-----
V
D
P
R
D
L
---------------------------------------
32
HHSearch
73.36
36%
6
- C4 -
4KP2
-
HACA_METJA
A:
[1-418]
----------------------------------
M
-
T
L
V
E
K
I
L
S
K
K
V
-
G
Y
-
E
----
V
C
A
G
-
D
S
I
------
E
V
E
--
V
D
L
A
M
T
H
D
G
T
T
P
L
A
Y
K
A
L
K
E
M
---
S
-
D
S
V
-
W
N
P
D
K
I
------
V
V
A
F
D
H
N
V
P
--
P
----
N
T
V
-------
K
--------
A
A
E
M
Q
-
K
L
A
L
E
F
V
--
K
R
F
-----------
G
I
K
N
F
-
H
K
G
G
---
E
G
I
C
H
Q
I
L
A
E
---------
N
----------
Y
V
L
P
N
M
F
V
A
G
G
D
S
H
T
C
T
H
G
A
F
G
A
F
A
T
G
F
G
A
T
D
M
A
Y
I
Y
A
T
G
E
T
W
I
K
V
P
K
T
I
R
V
D
I
V
G
K
-
N
E
N
V
S
A
K
D
I
V
L
R
V
----
C
K
--
E
I
G
------
R
R
G
A
--
T
Y
M
A
I
E
Y
G
G
E
V
V
K
N
M
D
M
D
G
R
L
T
L
C
N
M
A
I
E
M
G
G
K
T
G
V
I
E
A
-
D
-
E
I
T
Y
D
Y
L
-------
K
K
E
----------
R
G
L
--
S
----
D
----------
E
D
I
A
-
K
--
L
K
K
E
R
-
I
T
V
N
R
D
E
A
N
Y
Y
K
E
I
E
I
D
I
T
D
M
-
E
-
E
Q
V
A
V
P
H
H
P
-------
D
N
----------------------------------------------
V
K
P
I
S
D
V
E
G
T
E
I
N
Q
V
F
I
G
S
C
T
N
G
R
L
S
D
L
R
E
A
A
K
Y
L
------
K
------
G
R
---
E
---
V
H
K
D
V
K
L
----
I
V
I
P
A
S
K
K
V
F
L
Q
A
L
K
E
G
I
I
D
I
F
V
K
A
G
A
M
I
C
T
P
G
C
G
P
C
L
G
A
---
H
Q
--
G
V
-
L
A
E
--------
G
--
E
---
I
--
C
L
S
---
T
T
N
R
N
F
K
G
R
M
G
H-
I
--
N
S
Y
-
I
Y
--
L
A
--
S
P
K
I
A
A
I
S
A
V
K
G
Y
I
-----
T
N
K
------------------------------------------
21
PsiBlast_CBE
72.86
33%
10
- C4 -
4NQY
1
LEUC_METJA
B:
[22-442]
----------------------------------
M
-
T
I
V
E
K
I
L
A
K
A
S
-
G
K
-
K
----
E
-
V
S
-
P
G
D
------
I
V
M
AN
I
D
V
A
M
V
H
D
I
T
G
P
L
T
V
N
T
L
K
E
Y
---
G
I
E
K
V
-
W
N
P
E
K
I
------
V
I
L
F
D
----------------------------
N
H
I
L
M
R
K
F
V
--------
K
E
Q
-----------
G
I
-
K
Y
---
F
Y
D
I
R
E
G
V
C
H
Q
V
L
P
E
---------
K
---------
G
H
V
A
P
G
E
V
V
V
G
A
D
S
H
T
C
T
H
G
A
F
G
A
F
A
T
G
I
G
S
T
D
M
A
H
V
F
A
T
G
K
L
W
F
K
V
P
E
T
I
Y
F
N
I
T
G
D
L
Q
P
Y
V
T
S
K
D
V
I
L
S
I
----
I
G
--
E
V
G
------
V
D
G
A
--
T
Y
K
A
C
Q
F
G
G
E
T
V
K
K
M
S
I
A
S
R
M
T
M
T
N
M
A
I
E
M
G
G
K
T
G
I
I
E
P
-
D
-
E
K
T
I
Q
Y
V
-------
K
-
E
----------
A
M
K
--
K
----
H
---------
G
T
E
-------
R
P
F
E
-
V
I
K
G
D
E
D
A
E
F
A
E
V
Y
E
I
E
A
D
K
I
-
E
-
P
V
F
A
C
P
H
N
V
---------------------------------
D
-
N
V
K
Q
A
-------------------
R
E
V
A
G
K
P
I
D
Q
V
F
I
G
S
C
T
N
G
R
L
E
D
L
R
M
A
I
K
I
I
E-----
K
------
H
G
---
G
---
I
A
D
D
V
R
V
----
V
V
T
P
A
S
R
E
E
Y
L
K
A
L
K
E
G
I
I
E
K
F
L
K
Y
G
C
V
V
T
N
P
S
C
S
A
C
M
G
S
---
L
Y
--
G
V
-
L
G
P
--------
G
--
E
---
V
--
C
V
S
---
T
S
N
R
N
F
R
G
R
Q
G
--
S
L-
E
A
E
-
I
Y
--
L
A
--
S
P
I
T
A
A
A
C
A
V
K
G
E
L
-----
V
D
P
R
D
----------------------------------------
2
PsiBlast_PDB
72.80
33%
10
- C4 -
4NQY
1
LEUC_METJA
A:
[22-442]
----------------------------------
M
-
T
I
V
E
K
I
L
A
K
A
S
-
G
K
-
K
----
E
-
V
S
-
P
G
D
------
I
V
M
A
N
I
D
V
A
M
V
H
D
I
T
G
P
L
T
V
N
T
L
K
E
Y
---
G
I
E
K
V
-
W
N
P
E
K
I
------
V
I
L
F
D
----------------------------
N
H
I
L
M
R
K
F
V
--------
K
E
Q
-----------
G
I
-
K
Y
---
F
Y
D
I
R
E
G
V
C
H
Q
V
L
P
E
---------
K
---------
G
H
V
A
P
G
E
V
V
V
G
A
D
S
H
T
C
T
H
G
A
F
G
A
F
A
T
G
I
G
S
T
D
M
A
H
V
F
A
T
G
K
L
W
F
K
V
P
E
T
I
Y
F
N
I
T
G
D
L
Q
P
Y
V
T
S
K
D
V
I
L
S
I
----
I
G
--
E
V
G
------
V
D
G
A
--
T
Y
K
A
C
Q
F
G
G
E
T
V
K
K
M
S
I
A
S
R
M
T
M
T
N
M
A
I
E
M
G
G
K
T
G
I
I
E
P
-
D
-
E
K
T
I
Q
Y
V
-------
K
-
E
----------
A
M
K
--
K
----
H
---------
G
T
E
-------
R
P
F
E
-
V
I
K
G
D
E
D
A
E
F
A
E
V
Y
E
I
E
A
D
K
I
-
E
-
P
V
F
A
C
P
H
N
V
---------------------------------
D
-
N
V
K
Q
A
-------------------
R
E
V
A
G
K
P
I
D
Q
V
F
I
G
S
C
T
N
G
R
L
E
D
L
R
M
A
I
K
I
I
E
-----
K
------
H
G
---
G
---
I
A
D
D
V
R
V
----
V
V
T
P
A
S
R
E
E
Y
L
K
A
L
K
E
G
I
I
E
K
F
L
K
Y
G
C
V
V
T
N
P
S
C
S
A
C
M
G
S
---
L
Y
--
G
V
-
L
G
P
--------
G
--
E
---
V
--
C
V
S
---
T
S
N
R
N
F
R
G
R
Q
G
--
S
L-
E
A
E
-
I
Y
--
L
A
--
S
P
I
T
A
A
A
C
A
V
K
G
E
L
-----
V
D
P
R
D
----------------------------------------
1
PsiBlast_PDB
72.56
34%
11
- C4 -
4KP2
-
HACA_METJA
A:
[1-417]
-----------------------------------M
T
L
V
E
K
I
L
S
K
K
V
G
Y
E
-
V
----
C
-
A
G
-
D
S
I
------
E
V
E
--
V
D
L
A
M
T
H
D
G
T
T
P
L
A
Y
K
A
L
K
E
M
---
S
-
D
S
V
-
W
N
P
D
K
I
------
V
V
A
F
D
H
N
V
P
PN
T
----
V
-----------------
K
A
A
E
M
Q
K
L
A
L
E
F
-
V
--
K
R
F
-----------
G
I
-
K
---
N
F
H
K
G
G
E
G
I
C
H
Q
I
L
A
E
-------------------
N
Y
V
L
P
N
M
F
V
A
G
G
D
S
H
T
C
T
H
G
A
F
G
A
F
A
T
G
F
G
A
T
D
M
A
Y
I
Y
A
T
G
E
T
W
I
K
V
P
K
T
I
R
V
D
I
V
G
K
-
N
E
N
V
S
A
K
D
I
V
L
R
V
----
C
K
--
E
I
G
------
R
R
G
A
--
T
Y
M
A
I
E
Y
G
G
E
V
V
K
N
M
D
M
D
G
R
L
T
L
C
N
M
A
I
E
M
G
G
K
T
G
V
I
E
A
-
D
-
E
I
T
Y
D
Y
L
-------
K
K
E
----------
R
G
L
--
S
----
D
----------
E
D
I
A
K
L
--
K
K
E
R
I
-
T
V
N
R
D
E
-
A
N
Y
Y
K
E
I
E
I
D
I
T
D
M
-
E
-
E
Q
V
A
V
P
H
H
P
-------
D
N
V
K
P
I
S
D
----------------------------------------------
V
E
G
T
E
I
N
Q
V
F
I
G
S
C
T
N
G
R
L
S
D
L
R
E
A
A
K
Y
L
------
K
------
G
R
---
E
---
V
H
K
D
V
K
L
----
I
V
I
P
A
S
K
K
V
F
L
Q
A
L
K
E
G
I
I
D
I
F
V
K
A
G
A
M
I
C
T
P
G
C
G
P
C
L
G
A
---
H
Q
--
G
V
-
L
A
E
--------
G
--
E
---
I
--
C
L
S
---
T
T
N
R
N
F
K
G
R
M
G
--
H
I-
N
S
Y
-
I
Y
--
L
A
--
S
P
K
I
A
A
I
S
A
V
K
G
Y
I
-----
T
N
-------------------------------------------
33
HHSearch
67.63
26%
15
* C4 *
1C96
3
ACON_BOVIN
A:
[32-482]
-------------------------------
N
R
P
L
-
T
L
S
E
K
I
V
Y
G
H
L
-
D
D
-
P
ANQ
E
I
E
R
G
K
T
Y
L
------
R
L
R
--
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
G--
L
-
P
K
V
-
A
V
P
S
T
I
--------
H
C
D
H
L
I
E
--
A
----
Q
L
G
G
E
-----
K
D
L
R
R
A
K
D
I
N
Q
E
V
Y
-
N
F
L
A
T
A
G
--
A
K
Y
-----------
G
V
-
G
F
-
W
R
P
G
---
S
G
I
I
H
Q
I
I
L
E
---------
N
----------
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
----
A
G
--
I
L
T
------
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
-
N
-
H
R
M
K
K
Y
L
-------
S
K
T
----------
G
R
A
--
D
----
I
------------
A
N
L
A
--
D
E
F
K
D
-
H
L
V
P
D
P
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
-
K
-
P
H
I
N
G
P
F
T
P
-------
D
L
A
H
P
V
A
E
V
G
S
V
A
--------------------------------------
E
K
E
G
W
P
L
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
Q
A
L
A
H
-
G
L
---
K
---
C
--
K
S
Q
F
----
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
---
W
D
RK
D
I
K
K
G
E
--------
K
--
N
---
T
--
I
V
T
---
S
Y
N
R
N
F
T
G
R
N
D
AN
P
--
E
T
H
-
A
F
--
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
T
L
-----
K
F
N
P
E
----------------------------------------
24
Fugue
65.69
25%
5
- C4 -
1C96
3
ACON_BOVIN
A:
[33-479]
--------------------------------
R
P
L
-
T
L
S
E
K
I
V
Y
G
H
L
-
D
D
-
P
----
A
-
N
Q
-
E
I
E
R
GKTYL
R
L
R
--
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
---
G
-
L
P
K
-
V
A
V
-
P
S
------
T
I
H
C
D
H
L
I
E
--
A
----
Q
L
G
-------
G
E
K
D
---
L
R
R
A
K
D
I
N
Q
E
V
Y
N
F
L
--
A
T
A
-----------
G
A
-
K
Y
G
V
G
F
W
R
P
G
S
G
I
I
H
Q
I
I
L
E
---------
N
----------
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
----
A
G
--
I
L
T
------
V
K
--GG
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
N--
H
R
M
K
K
Y
L
-------
S
K
T
---------------------GR
A
D
I
A
N
L
A
D
E
F
K
D
H
----------
L
V
P
D
P
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
--
K
P
H
I
N
G
P
F
T
P
-------
D
L
A
H
P
V
A
E
V
G
S
V
A
E
K
E
G
--------------------------------------
W
P
L
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
------
Q
A
L
A
H
G
---
L
K
C
K
S
Q
F
----
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
---
W
D
R-
K
D
-
I
K
K
--------
G
E
K
N
---
T
--
I
V
T
---
S
Y
N
R
N
F
T
G
R
N
D
--
A
NP
E
T
H
-
A
F
--
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
T
L
-----
K
F
-------------------------------------------
22
Fugue
62.77
24%
24
- C4 -
1ACO
2
?
?:
[2-528]
RAKVAMSHFEPH
E
Y
I
R
Y
D
L
L
E
K
N
I
D
I
V
R
K
R
L
N
R
P
L
-
T
L
S
E
K
I
V
Y
G
H
L
-
D
D
-
P
----
A
-
N
Q
-
E
I
E
R
G
K
T
Y
L
R
L
R
--
P
D
R
V
A
M
Q
D
A
T
A
Q
M
A
M
L
Q
F
I
S
S
---
G
-
L
P
--
K
V
A
V
P
S
------
T
I
H
C
D
H
L
I
E
--
A
Q
LGG
E
K
D
-------
L
R
R
A
---
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
--
A
K
Y
-----------
G
V
-
G
F
-
W
R
P
---
G
S
G
I
I
H
Q
I
I
L
E
---------
N
----------
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
----
A
G
--
I
L
T
------
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
F
P
Y
-
N
-
H
R
M
K
K
Y
L
-------
S
K
-------------
T
--
G
----
R
---------
A
D
I
A
N
L
A
--
D
E
F
K
D
-
H
L
V
P
D
S
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
-
K
-
P
H
I
N
G
P
F
T
P
-------
D
L
A
H
P
--------------------------------------
V
A
E
V
G
S
V
A
E
K
E
G
W
P
L
D
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
------
Q
A
---
L
A
H
G
L
K
C
K
S
Q
F
----
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
WDR
K
D
--
I
K
-
K
G
E
--------
K
--
N
---
T
--
I
V
T
---
S
Y
N
R
N
F
T
G
R
N
D
--
A
--
N
P
E
-
T
H
--
A
F
V
T
S
P
E
I
V
T
A
L
A
I
A
G
T
L
KFNPE
T
D
F
L
T
G
K
D
G
K
K
F
K
L
E
A
P
D
A
D
ELPRAEFDPGQDT
Y
Q
H
P
PKDSSG
Q
R
35
HHSearch
61.89
22%
-5
- C4 -
2B3Y
4
ACOC_HUMAN
A:
[72-569]
-----------------------------------------------------------
N
-
I
E
V
------
P
F
K
--
P
A
R
V
I
L
Q
D
F
T
G
V
P
A
V
V
D
F
A
A
M
R
D
A
V
-
K
K
L
G
G
D
P
E
K
I
NPV
C
P
A
D
L
V
I
D
H
S
I
Q
--
V
----
D
F
N
RRAD
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
E
R
F
-
E
F
L
-
K
W
G
S
Q
A
F
H
-----------
N
M
-
R
I
-
I
P
P
G
---
S
G
I
I
H
Q
V
N
L
E
YLARVVFDQ
D
---------
G
Y
Y
Y
P
D
-
S
L
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
I
----
T
K
--
H
L
R
------
Q
V
G
V
--
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
-
D
-
E
V
S
I
T
Y
L
-------
V
Q
T
----------
G
R
D
--
E
E
K
L
K
Y
---------
I
K
K
Y
L
Q
A
--
V
G
M
F
R
D
F
N
D
P
S
Q
D
P
D
F
T
Q
V
V
E
L
D
L
K
T
V
-
V
-
P
C
C
S
G
P
K
R
P
-------
Q
D
K
V
A
V
S
D
M
K
K
D
F
E
S
C
L
G
-------
A
K
Q
G
F
K
G
F
QVAPEHH
N
D
H
K
T
F
I
Y
D
N
T
E
F
T
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
------
A
K
K
A
V
D
A
G
L
---
N
---
V
M
P
Y
I
K
T
----
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
N
---
S
---
G
P
-
L
P
E
P
V
V
E
A
I
T
Q
G
--
D
LV
A
V
--
G
V
L
---
S
G
N
R
N
F
E
G
R
V
H
P-
N
--
T
R
A
-
N
Y
--
L
A
--
S
P
P
L
V
I
A
Y
A
I
A
G
T
I
-----
R
I
D
F
-----------------------------------------
20
PsiBlast_PDB
61.19
25%
15
- C4 -
2B3Y
3
ACOC_HUMAN
A:
[123-563]
------------------------------------------------------------------------------------------------------------------------
I
D
H
S
I
---
Q
----
V
D
F
-------
N
R
R
A
---
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
--
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
N
M
-
R
I
-
I
P
P
G
S
---
G
I
I
H
Q
V
N
L
E
---------
Y
LARVVFDQD
G
Y
Y
Y
P
-
D
S
L
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
-----
I
T
--
K
H
L
------
R
Q
V
G
V-
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
-
D
-
E
V
S
I
T
Y
L
V
Q
T
GRD
E
E
K
L
----------
K
Y
I
--
K
----
K
---------
Y
L
Q
A
V
G
M
--
F
R
D
F
N
-
D
P
S
Q
D
P
D
--
F
T
Q
V
V
E
L
D
L
K
T
V
-
V
-
P
C
C
S
G
P
K
R
P
QDKVAVS
D
M
K
K
D
F
E
S
C
L
G
A
K
Q
G
F
K
G
FQVAPEH
H
N
-
D
H
K
T
F
-------
I
--
Y
D
N
T
E
F
T
----
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
------
G
L
---
N
---
V
M
P
Y
I
K
T
----
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
----
N
S
--
G
P
-
L
P
E
P
V
V
E
A
I
T
Q
G
--
D
---
L
--
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
--
P
--
N
T
R
A
N
Y
--
L
A
--
S
P
P
L
V
I
A
Y
A
I
A
G
----------------------------------------------------
19
PsiBlast_PDB
60.37
25%
14
- C4 -
2B3X
3
ACOC_HUMAN
A:
[123-563]
------------------------------------------------------------------------------------------------------------------------
I
D
H
S
I
---
Q
----
V
D
F
-------
N
R
R
A
---
D
S
L
Q
K
N
Q
D
L
E
F
E
R
N
R
--
E
R
F
E
F
L
K
W
G
S
Q
A
F
H
N
M
-
R
I
-
I
P
P
G
S
---
G
I
I
H
Q
V
N
L
E
---------
Y
LARVVFDQD
G
Y
Y
Y
P
-
D
S
L
V
G
T
D
S
H
T
T
M
I
D
G
L
G
I
L
G
W
G
V
G
G
I
E
A
E
A
V
M
L
G
Q
P
I
S
M
V
L
P
Q
V
I
G
Y
R
L
M
G
K
P
H
P
L
V
T
S
T
D
I
V
L
T
-----
I
T
--
K
H
L
------
R
Q
V
G
V-
V
G
K
F
V
E
F
F
G
P
G
V
A
Q
L
S
I
A
D
R
A
T
I
A
N
M
C
P
E
Y
G
A
T
A
A
F
F
P
V
-
D
-
E
V
S
I
T
Y
L
V
Q
T
GRD
E
E
K
L
----------
K
Y
I
--
K
----
K
---------
Y
L
Q
A
V
G
M
--
F
R
D
F
N
-
D
P
S
Q
D
P
D
--
F
T
Q
V
V
E
L
D
L
K
T
V
-
V
-
P
C
C
S
G
P
K
R
P
QDKVAVS
D
M
K
K
D
F
E
S
C
L
G
A
K
Q
G
F
K
G
FQVAPEH
H
N
-
D
H
K
T
F
-------
I
--
Y
D
N
T
E
F
T
----
L
A
H
G
S
V
V
I
A
A
I
T
S
C
T
N
T
S
N
P
S
V
M
L
G
A
G
L
L
A
K
K
A
V
D
A
------
G
L
---
N
---
V
M
P
Y
I
K
T
----
S
L
S
P
G
S
G
V
V
T
Y
Y
L
Q
E
S
G
V
M
P
Y
L
S
Q
L
G
F
D
V
V
G
Y
G
C
M
T
C
I
G
----
N
S
--
G
P
-
L
P
E
P
V
V
E
A
I
T
Q
G
--
D
---
L
--
V
A
V
G
V
L
S
G
N
R
N
F
E
G
R
V
H
--
P
--
N
T
R
A
N
Y
--
L
A
--
S
P
P
L
V
I
A
Y
A
I
A
G
----------------------------------------------------
36
HHSearch
59.42
23%
5
- C4 -
1L5J
2
ACNB_ECOLI
A:
[379-828]
-------------------------------
D
R
G
F
-
S
L
A
Q
K
M
V
G
R
A
C
-
G
V
K
G
----
I
R
P
G
-
A
Y
C
------
E
P
K
--
M
T
S
V
G
S
Q
D
T
T
G
P
M
T
R
D
E
L
K
D
L
---
A
-
C
L
G
-
F
S
A
D
L
V
------
M
Q
S
F
C
H
T
A
A
--
Y
----
P
K
P
-------
V
--------
D
V
N
T
H
-
H
T
L
P
D
F
I
M
-
N
R
G
-----------
G
V
-
S
L
--
R
P
G
---
D
G
V
I
H
S
W
L
N
R
--------------------
M
L
L
P
D
T
V
G
T
G
G
D
S
H
T
R
F
P
I
G
---
I
S
F
P
A
G
S
G
L
V
A
F
A
A
A
T
G
V
M
P
L
D
M
P
E
S
V
L
V
R
F
K
G
K
M
Q
P
G
I
T
L
R
D
L
V
H
A
I
P
L
Y
A
I
K
Q
G
L
L
T
VEKKGK
K
N
I
F
--
S
G
R
I
L
E
I
E
--
G
L
P
D
L
K
V
E
Q
A
F
E
L
T
D
A
S
A
E
R
S
A
A
G
C
T
I
K
L
-
N
K
E
P
I
I
E
Y
L
-------
N
S
N
I
V
L
L
K
W
M
I
A
E
G
Y
G
D
R
R
----
T
L
E
R
R
-----
I
Q
G
M
E
K
W
--
L
A
N
P
E
-
L
L
E
A
D
A
D
A
E
Y
A
A
V
I
D
I
D
L
A
D
I
K
E
-
P
I
L
C
A
P
N
D
P
-------
D
D
----------------------------------------------
A
R
P
L
S
A
V
Q
G
E
K
I
D
E
V
F
I
G
S
C
M
T
-
N
I
G
H
F
R
A
A
G
K
L
L
------
D
------
A
H
---
K
---
G
Q
L
P
T
R
L
----
W
V
A
P
P
T
R
M
D
A
A
Q
L
T
E
E
G
Y
Y
S
V
F
G
K
S
G
A
R
I
E
I
P
G
C
S
L
C
M
G
N
---
Q
---
A
R
-
V
A
D
--------
G
--
A
---
T
--
V
V
S
---
T
S
T
R
N
F
P
N
R
L
G
--
T
--
G
A
N
-
V
F
--
L
A
--
S
A
E
L
A
A
V
A
A
L
I
G
K
L
-----
P
T
P
E
E
Y
Q
T
-------------------------------------
7
PsiBlast_PDB
59.28
28%
-23
- C4 -
5ACN
2
ACON_PIG
A:
[144-476]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
I
H
Q
I
I
L
E
-------------------
N
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
----
A
G
--
I
L
T
------
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
---------
F
P
Y
N
H
------
R
M
K
----------
K
Y
L
--
S
----
K
---------
T
G
R
A
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
P
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
-
K
-
P
H
I
N
G
P
F
T
P
-------
D
L
A
H
P
V
-
A
E
V
---------------------
G
S
-------
V
A
E
K
E
G
W
P
L
-------
D
I
R
V
G
--
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
-------
Q
---
A
---
L
A
H
G
L
K
C
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W--
D
R
--
K
D
-
I
K
K
--------
G
--
E
---
K
N
T
I
V
T
---
S
Y
N
R
N
F
T
G
R
N
D
--
A
--
N
P
E
-
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
14
PsiBlast_PDB
59.19
28%
-22
- C4 -
1NIS
2
ACON_BOVIN
A:
[144-476]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
I
H
Q
I
I
L
E
-------------------
N
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
----
A
G
--
I
L
T
------
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
---------
F
P
Y
N
H
------
R
M
K
----------
K
Y
L
--
S
----
K
---------
T
G
R
A
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
S
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
-
K
-
P
H
I
N
G
P
F
T
P
-------
D
L
A
H
P
V
-
A
E
V
---------------------
G
S
-------
V
A
E
K
E
G
W
P
L
-------
D
I
R
V
G
--
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
-------
Q
---
A
---
L
A
H
G
L
K
C
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W--
D
R
--
K
D
-
I
K
K
--------
G
--
E
---
K
N
T
I
V
T
---
S
Y
N
R
N
F
T
G
R
N
D
--
A
--
N
P
E
-
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
5
PsiBlast_PDB
59.19
28%
-21
- C4 -
1C97
3
ACON_BOVIN
A:
[143-475]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
I
H
Q
I
I
L
E
-------------------
N
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
----
A
G
--
I
L
T
------
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
---------
F
P
Y
N
H
------
R
M
K
----------
K
Y
L
--
S
----
K
---------
T
G
R
A
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
P
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
-
K
-
P
H
I
N
G
P
F
T
P
-------
D
L
A
H
P
V
-
A
E
V
---------------------
G
S
-------
V
A
E
K
E
G
W
P
L
-------
D
I
R
V
G
--
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
-------
Q
---
A
---
L
A
H
G
L
K
C
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W--
D
R
--
K
D
-
I
K
K
--------
G
--
E
---
K
N
T
I
V
T
---
S
Y
N
R
N
F
T
G
R
N
D
--
A
--
N
P
E
-
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
8
PsiBlast_PDB
59.14
28%
-23
- C4 -
6ACN
2
ACON_PIG
A:
[144-476]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
I
H
Q
I
I
L
E
-------------------
N
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
----
A
G
--
I
L
T
------
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
---------
F
P
Y
N
H
------
R
M
K
----------
K
Y
L
--
S
----
K
---------
T
G
R
A
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
P
G
C
H
Y
D
Q
V
I
E
I
N
L
S
E
L
-
K
-
P
H
I
N
G
P
F
T
P
-------
D
L
A
H
P
V
-
A
E
V
---------------------
G
S
-------
V
A
E
K
E
G
W
P
L
-------
D
I
R
V
G
--
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
-------
Q
---
A
---
L
A
H
G
L
K
C
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W--
D
R
--
K
D
-
I
K
K
--------
G
--
E
---
K
N
T
I
V
T
---
S
Y
N
R
N
F
T
G
R
N
D
--
A
--
N
P
E
-
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
15
PsiBlast_PDB
58.93
28%
-22
- C4 -
1NIT
2
ACON_BOVIN
A:
[144-476]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
I
H
Q
I
I
L
E
-------------------
N
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
----
A
G
--
I
L
T
------
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
---------
F
P
Y
N
H
------
R
M
K
----------
K
Y
L
--
S
----
K
---------
T
G
R
A
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
S
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
-
K
-
P
H
I
N
G
P
F
T
P
-------
D
L
A
H
P
V
-
A
E
V
---------------------
G
S
-------
V
A
E
K
E
G
W
P
L
-------
D
I
R
V
G
--
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
-------
Q
---
A
---
L
A
H
G
L
K
C
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W--
D
R
--
K
D
-
I
K
K
--------
G
--
E
---
K
N
T
I
V
T
---
S
Y
N
R
N
F
T
G
R
N
D
--
A
--
N
P
E
-
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
18
PsiBlast_PDB
58.89
28%
-21
- C4 -
8ACN
2
ACON_BOVIN
A:
[144-476]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
I
H
Q
I
I
L
E
-------------------
N
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
----
A
G
--
I
L
T
------
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
---------
F
P
Y
N
H
------
R
M
K
----------
K
Y
L
--
S
----
K
---------
T
G
R
A
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
S
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
-
K
-
P
H
I
N
G
P
F
T
P
-------
D
L
A
H
P
V
-
A
E
V
---------------------
G
S
-------
V
A
E
K
E
G
W
P
L
-------
D
I
R
V
G
--
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
-------
Q
---
A
---
L
A
H
G
L
K
C
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W--
D
R
--
K
D
-
I
K
K
--------
G
--
E
---
K
N
T
I
V
T
---
S
Y
N
R
N
F
T
G
R
N
D
--
A
--
N
P
E
-
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------
13
PsiBlast_PDB
58.87
28%
-22
- C4 -
1AMJ
2
ACON_BOVIN
A:
[144-476]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
I
H
Q
I
I
L
E
-------------------
N
Y
A
Y
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
G
I
C
I
G
V
G
G
A
D
A
V
D
V
M
A
G
I
P
W
E
L
K
C
P
K
V
I
G
V
K
L
T
G
S
L
S
G
W
T
S
P
K
D
V
I
L
K
V
----
A
G
--
I
L
T
------
V
K
G
G
--
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
T
I
C
N
M
G
A
E
I
G
A
T
T
S
V
---------
F
P
Y
N
H
------
R
M
K
----------
K
Y
L
--
S
----
K
---------
T
G
R
A
D
I
A
N
L
A
D
E
F
K
D
H
L
V
P
D
S
G
C
H
Y
D
Q
L
I
E
I
N
L
S
E
L
-
K
-
P
H
I
N
G
P
F
T
P
-------
D
L
A
H
P
V
-
A
E
V
---------------------
G
S
-------
V
A
E
K
E
G
W
P
L
-------
D
I
R
V
G
--
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
A
V
A
------
K
-------
Q
---
A
---
L
A
H
G
L
K
C
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Q
V
L
R
D
V
G
G
I
V
L
A
N
A
C
G
P
C
I
G
Q
W--
D
R
--
K
D
-
I
K
K
--------
G
--
E
---
K
N
T
I
V
T
---
S
Y
N
R
N
F
T
G
R
N
D
--
A
--
N
P
E
-
T
H
A
F
V
T
--
S
P
E
I
V
T
A
L
A
I
A
G
----------------------------------------------------