@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu28280: (2016-07-14 )
MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEAGFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATSDIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDAGASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIENGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLTGMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRHAFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEFLSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDYRIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMSGLKNHTAVGS
Atome Classification :
(22 SA)
---------------------------------------------------.......---..10........20...-.....30-.-.....-..40........50........60--.-...---.-....70........80........90........100.......110.......120......-----.130-.---.---.-------.---..--.----..140-.....--....150.......160------.------......170.-......180...-....190........200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300...--------------------....-310.......-320-..-----...-..330.......340.....-...350.....--..360.--..-.-.--..370.-......380...----....390.......400.......410.......420.......430.......440.......450..-.....460.......------470.-......480.......490.......500.......510......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------M
R
K
I
NFF---DTTLRDGEQSPGVNL
N
T
-
Q
E
K
L
A
I
A
-
K
-
Q
L
E
R
L
-
G
A
D
I
I
EAGFPASSRGD
F
L
A
V
Q
E
I
---
A
-
R
T
I
---
K
-NC
S
V
T
G
L
A
R
C
VKG
D
I
D
A
A
W
E
A
L
K
DGAQ
P
R
I
H
V
F
I
ATS
D
I
H
L
K
H
K
L
K
M
T
R
E
Q
V
I
E
R
A
V
G
M
V
K
Y
A
-----
K
E---R---F---
P
-------
I
---
V
Q
--W----SAE---
D
A
C
RT--E
L
P
F
L
A
E
I
V
E
K
V
I
DAGA------
S
------
V
INLPDTVGY-LAPAEY
G
N
I
F
K
Y
-
M
K
E
NV-PN
I
H
K
A
K
L
S
AHCH
D
D
L
G
M
A
V
A
N
S
L
A
A
IENGA
D
Q
I
E
C
A
VNGIGERA
G
N
A
A
L
E
E
I
A
V
A
L
HTRK
D
F
Y
Q
VETGI
T
L
N
E
I
K
R
T
S
D
L
V
S
K
L
TGMAVPRN
K
A
VVGDNAFAHESGIHQDGFLK--------------------EKS
T
-
Y
E
IISP
E
L
V
G
-
V
TA-
D
A
-----
L
V
L
-GKHSG
R
H
A
F
K
D
R
L
-
T
A
LGFQ-F
D
S
E
E
I
N
K
F
F
T
--
M
F
K
E
L
T
--
E
K
-
K
-K--EI
T
D
E
D
-
L
V
S
L
I
L
E
EKVTD----
R
K
I
G
Y
E
F
L
S
L
Q
V
H
YGTSQV
P
T
A
T
L
S
LKNQ
E
N
A
Q
L
I
Q
E
AATGAG
S
V
E
A
I
Y
N
T
L
E
R
C
I
DKD
V
E
L
L
D
Y
R
IQS-NRKG
E
D
A
F
A
Q
V
Y
V
R
V
------LVNG-KESAG
R
G
I
A
Q
D
V
L
E
A
S
A
K
A
Y
L
N
A
V
N
R
Q
L
V
FQSNMSGLKNHTAVGS
1
PsiBlast_PDB
86.49
55%
-89
- C2 -
3RMJ
4
LEU1_NEIMB
A:
[12-330]
-----------------------------------------------------
R
V
I
I
F
---
D
T
T
L
R
D
G
E
Q
S
P
G
A
A
M
T
K
-
E
E
K
I
R
V
A
-
R
-
Q
L
E
K
L
-
G
V
D
I
I
E
A
G
F
A
A
A
S
P
G
D
F
E
A
V
N
A
I
---
A
-
K
T
I
---
T
-
K
S
T
V
C
S
L
S
R
A
I
E
R
D
I
R
Q
A
G
E
A
V
A
P
A
P
K
K
R
I
H
T
F
I
A
T
S
P
I
H
M
E
Y
K
L
K
M
K
P
K
Q
V
I
E
A
A
V
K
A
V
K
I
A
-----
R
E
---
Y
---
T
---
D
-------
D
---
V
E
--
F
----
S
C
E
---
D
A
L
R
S
--
E
I
D
F
L
A
E
I
C
G
A
V
I
E
A
G
A
------
T
------
T
I
N
I
P
D
T
V
G
Y
-
S
I
P
Y
K
T
E
E
F
F
R
E
-
L
I
A
K
T
-
P
N
G
G
K
V
V
W
S
A
H
C
H
N
D
L
G
L
A
V
A
N
S
L
A
A
L
K
G
G
A
R
Q
V
E
C
T
V
N
G
L
G
E
R
A
G
N
A
S
V
E
E
I
V
M
A
L
K
V
R
H
D
L
F
G
L
E
T
G
I
D
T
T
Q
I
V
P
S
S
K
L
V
S
T
I
T
G
Y
P
V
Q
P
N
K
A
I
V
G
A
N
A
F
S
----------------------------------
E
T
-
Y
E
I
M
S
A
E
S
V
G
-
W
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
86.32
54%
-88
- C2 -
3RMJ
4
LEU1_NEIMB
A:
[10-330]
---------------------------------------------------
T
N
R
V
I
I
F
---
D
T
T
L
R
D
G
E
Q
S
P
G
A
A
M
T
K
-
E
E
K
I
R
V
A
-
R
-
Q
L
E
K
L
-
G
V
D
I
I
E
A
G
F
A
A
A
S
P
G
D
F
E
A
V
N
A
I
---
A
-
K
T
I
---
T
-
K
S
T
V
C
S
L
S
R
A
I
E
R
D
I
R
Q
A
G
E
A
V
A
P
A
P
K
K
R
I
H
T
F
I
A
T
S
P
I
H
M
E
Y
K
L
K
M
K
P
K
Q
V
I
E
A
A
V
K
A
V
K
I
A
-----
R
E
---
Y
---
T
---
D
-------
D
---
V
E
--
F
----
S
C
E
---
D
A
L
R
S
--
E
I
D
F
L
A
E
I
C
G
A
V
I
E
A
G
A
------
T
------
T
I
N
I
P
D
T
V
G
Y
-
S
I
P
Y
K
T
E
E
F
F
R
E
-
L
I
A
K
T
-
P
N
G
G
K
V
V
W
S
A
H
C
H
N
D
L
G
L
A
V
A
N
S
L
A
A
L
K
G
G
A
R
Q
V
E
C
T
V
N
G
L
G
E
R
A
G
N
A
S
V
E
E
I
V
M
A
L
K
V
R
H
D
L
F
G
L
E
T
G
I
D
T
T
Q
I
V
P
S
S
K
L
V
S
T
I
T
G
Y
P
V
Q
P
N
K
A
I
V
G
A
N
A
F
S
----------------------------------
E
T
-
Y
E
I
M
S
A
E
S
V
G
-
W
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
84.55
60%
-93
- C- -
3EWB
-
LEU1_LISMF
X:
[1-275]
---------------------------------------------------
L
K
K
I
Q
F
F
---
D
T
T
L
R
D
G
E
-----
N
F
D
V
-
K
E
K
I
Q
I
A
-
L
-
Q
L
E
K
L
-
G
I
D
V
I
E
A
G
F
P
I
S
S
P
G
D
F
E
C
V
K
A
I
---
A
-
K
A
I
---
K
-
H
C
S
V
T
G
L
A
R
C
V
E
G
D
I
D
R
A
E
E
A
L
K
D
A
V
S
P
Q
I
H
I
F
L
A
T
S
D
V
H
M
E
Y
K
L
K
M
S
R
A
E
V
L
A
S
I
K
H
H
I
S
Y
A
-----
R
Q
---
K
---
F
---
D
-------
V
---
V
Q
--
F
----
S
P
E
---
D
A
T
R
S
--
D
R
A
F
L
I
E
A
V
Q
T
A
I
D
A
G
A
------
T
------
V
I
N
I
P
D
T
V
G
Y
-
T
N
P
T
E
F
G
Q
L
F
Q
D
-
L
R
R
E
I
-
K
Q
F
D
D
I
I
F
A
S
H
C
H
D
D
L
G
M
A
T
A
N
A
L
A
A
I
E
N
G
A
R
R
V
E
G
T
I
N
G
I
G
E
R
A
G
N
T
A
L
E
E
V
A
V
A
L
H
I
R
K
D
F
Y
Q
A
E
T
N
I
V
L
N
Q
F
K
N
S
S
D
L
I
S
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
84.14
59%
-93
- C- -
3EWB
-
LEU1_LISMF
X:
[1-275]
---------------------------------------------------
L
K
K
I
Q
F
F
---
D
T
T
L
R
D
G
E
-----
N
F
D
V
-
K
E
K
I
Q
I
A
-
L
-
Q
L
E
K
L
-
G
I
D
V
I
E
A
G
F
P
I
S
S
P
G
D
F
E
C
V
K
A
I
---
A
-
K
A
I
---
K
-
H
C
S
V
T
G
L
A
R
C
V
E
G
D
I
D
R
A
E
E
A
L
K
D
A
V
S
P
Q
I
H
I
F
L
A
T
S
D
V
H
M
E
Y
K
L
K
M
S
R
A
E
V
L
A
S
I
K
H
H
I
S
Y
A
-----
R
Q
---
K
---
F
---
D
-------
V
---
V
Q
--
F
----
S
P
E
---
D
A
T
R
S
--
D
R
A
F
L
I
E
A
V
Q
T
A
I
D
A
G
A
------
T
------
V
I
N
I
P
D
T
V
G
Y
-
T
N
P
T
E
F
G
Q
L
F
Q
D
-
L
R
R
E
I
-
K
Q
F
D
D
I
I
F
A
S
H
C
H
D
D
L
G
M
A
T
A
N
A
L
A
A
I
E
N
G
A
R
R
V
E
G
T
I
N
G
I
G
E
R
A
G
N
T
A
L
E
E
V
A
V
A
L
H
I
R
K
D
F
Y
Q
A
E
T
N
I
V
L
N
Q
F
K
N
S
S
D
L
I
S
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
82.24
55%
-109
- C2 -
3EEG
-
?
A:
[2-279]
---------------------------------------------------
G
K
R
I
F
V
F
---
D
T
T
L
R
D
G
-------
L
N
T
-
E
E
K
I
I
V
A
-
K
-
A
L
D
E
L
-
G
V
D
V
I
E
A
G
F
P
V
S
S
P
G
D
F
N
S
V
V
E
I
---
T
-
K
A
V
---
T
-
R
P
T
I
C
A
L
T
R
A
K
E
A
D
I
N
I
A
G
E
A
L
R
F
A
K
R
S
R
I
H
T
G
I
G
S
S
D
I
H
I
E
----
S
T
R
E
N
I
L
E
M
A
V
A
A
V
K
Q
A
-----
K
K
---
V
---
V
---
H
-------
E
---
V
E
--
F
----
F
C
E
---
D
A
G
R
A
--
D
Q
A
F
L
A
R
M
V
E
A
V
I
E
A
G
A
------
D
------
V
V
N
I
P
D
T
T
G
Y
-
M
L
P
W
Q
Y
G
E
R
I
K
Y
-
L
M
D
N
V
-
S
N
I
D
K
A
I
L
S
A
H
C
H
N
D
L
G
L
A
T
A
N
S
L
A
A
L
Q
N
G
A
R
Q
V
E
C
T
I
N
G
I
G
E
R
A
G
N
T
A
L
E
E
V
V
M
A
M
E
C
H
K
E
T
L
G
L
E
T
G
I
N
H
K
K
L
V
P
I
S
H
L
V
S
T
L
M
R
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.54
55%
-110
- C2 -
3EEG
-
?
A:
[3-279]
----------------------------------------------------
K
R
I
F
V
F
---
D
T
T
L
R
D
G
-------
L
N
T
-
E
E
K
I
I
V
A
-
K
-
A
L
D
E
L
-
G
V
D
V
I
E
A
G
F
P
V
S
S
P
G
D
F
N
S
V
V
E
I
---
T
-
K
A
V
---
T
-
R
P
T
I
C
A
L
T
R
A
K
E
A
D
I
N
I
A
G
E
A
L
R
F
A
K
R
S
R
I
H
T
G
I
G
S
S
D
I
H
I
E
----
S
T
R
E
N
I
L
E
M
A
V
A
A
V
K
Q
A
-----
K
K
---
V
---
V
---
H
-------
E
---
V
E
--
F
----
F
C
E
---
D
A
G
R
A
--
D
Q
A
F
L
A
R
M
V
E
A
V
I
E
A
G
A
------
D
------
V
V
N
I
P
D
T
T
G
Y
-
M
L
P
W
Q
Y
G
E
R
I
K
Y
-
L
M
D
N
V
-
S
N
I
D
K
A
I
L
S
A
H
C
H
N
D
L
G
L
A
T
A
N
S
L
A
A
L
Q
N
G
A
R
Q
V
E
C
T
I
N
G
I
G
E
R
A
G
N
T
A
L
E
E
V
V
M
A
M
E
C
H
K
E
T
L
G
L
E
T
G
I
N
H
K
K
L
V
P
I
S
H
L
V
S
T
L
M
R
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.61
34%
-4
- C2 -
4OV4
2
?
A:
[24-406]
----------------------------------------------------
K
T
I
H
I
Q
---
D
V
T
L
R
D
G
N
Q
A
L
K
R
P
W
T
I
-
D
E
K
I
E
V
F
-
D
-
L
L
V
E
L
-
N
V
D
G
I
E
V
G
F
P
S
S
N
E
T
E
F
H
T
C
Q
V
L
---
S
K
R
A
P
---
K
-
G
K
P
I
A
A
L
S
R
A
N
Q
N
E
I
A
V
T
W
E
A
I
Q
K
A
D
C
P
R
M
H
I
V
Y
P
V
S
D
F
S
I
K
H
V
L
K
I
S
E
K
E
V
L
Q
K
I
R
N
S
I
S
F
A
-----
R
S
---
I
---
V
---
G
-------
P
G
I
E
I
Q
--
F
----
S
G
E
HFG
D
A
I
E
N
---
F
A
F
T
K
E
A
F
L
T
A
I
E
A
G
A
------
N
------
I
I
N
L
P
N
T
V
E
R
-
Y
R
P
M
V
F
V
N
M
V
K
E
-
I
K
D
V
V
-
K
D
--
K
A
I
I
S
I
H
T
H
N
D
L
G
M
A
T
A
T
S
V
E
S
V
Y
V
G
A
E
Q
I
E
V
A
L
N
G
L
G
E
R
A
G
N
T
N
L
Y
E
T
A
I
A
L
H
Q
N
G
E
----
N
L
N
I
N
F
Q
R
I
Y
P
T
A
K
R
I
S
E
L
T
G
I
P
I
G
E
K
T
P
I
I
G
E
D
I
F
S
H
R
S
G
I
H
Q
-----HQ------------------
S
K
G
A
-
Y
R
T
F
S
P
E
F
V
G
R
M
D
K
-
E
T
-----
I
S
F
-
T
N
Q
S
G
H
K
A
I
E
F
L
L
-
H
Q
R
G
I
Q
-
V
S
K
E
G
I
H
H
L
F
S
--
L
A
K
S
I
S
S
R
E
N
-
N
-
R
--
E
I
T
E
A
E
-
L
V
A
L
---------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
73.46
35%
9
- C2 -
4OV4
2
?
A:
[23-408]
---------------------------------------------------
P
K
T
I
H
I
Q
---
D
V
T
L
R
D
G
N
Q
A
L
K
R
P
W
T
I
-
D
E
K
I
E
V
F
-
D
-
L
L
V
E
L
-
N
V
D
G
I
E
V
G
F
P
S
S
N
E
T
E
F
H
T
C
Q
V
L
---
S
-
K
R
A
---
P
K
G
K
P
I
A
A
L
S
R
A
N
Q
N
E
I
A
V
T
W
E
A
I
Q
K
A
D
C
P
R
M
H
I
V
Y
P
V
S
D
F
S
I
K
H
V
L
K
I
S
E
K
E
V
L
Q
K
I
R
N
S
I
S
F
A
-----
R
S
---
I
V
GP
G
---
I
-------
E
---
I
Q
--
F
----
S
G
E
---
H
F
G
D
A
IE
N
F
A
F
T
K
E
A
F
L
T
A
I
E
A
G
A
------
N
------
I
I
N
L
P
N
T
V
E
R
-
Y
R
P
M
V
F
V
N
M
V
K
E
-
I
K
D
V
V
-
K
--
D
K
A
I
I
S
I
H
T
H
N
D
L
G
M
A
T
A
T
S
V
E
S
V
Y
V
G
A
E
Q
I
E
V
A
L
N
G
L
G
E
R
A
G
N
T
N
L
Y
E
T
A
I
A
L
H
Q
N
----
G
E
N
L
N
I
N
F
Q
R
I
Y
P
T
A
K
R
I
S
E
L
T
G
I
P
I
G
E
K
T
P
I
I
G
E
D
I
F
S
H
R
S
G
I
H
Q
-----HQ------------------
S
K
G
A
-
Y
R
T
F
S
P
E
F
V
G
-
R
M
D
K
E
T
-----
I
S
F
-
T
N
Q
S
G
H
K
A
I
E
F
L
L
-
H
Q
R
G
I
Q
-
V
S
K
E
G
I
H
H
L
F
S
--
L
A
K
S
I
S
--
S
R
E
N
N
R
--
E
I
T
E
A
E
-
L
V
A
L
S
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
72.62
24%
2
- C2 -
3HPS
6
LEU1_MYCTU
A:
[79-641]
----------------------------------------------------------------
L
R
D
G
N
Q
A
L
I
D
P
M
S
P
-
A
R
K
R
R
M
F
-
D
-
L
L
V
R
M
-
G
Y
K
E
I
E
V
G
F
P
S
A
S
Q
T
D
F
D
F
V
R
E
I
I
E
Q
G
-
A
I
P
---
D
-
D
V
T
I
Q
V
L
T
Q
C
R
P
E
L
I
E
R
T
F
Q
A
C
S
G
A
P
R
A
I
V
H
F
Y
N
S
T
S
I
L
Q
R
R
V
V
F
R
A
N
R
A
E
V
Q
A
I
A
T
D
G
A
R
K
C
-----
V
E
Q
A
A
K
---
Y
---
P
-------
G
---
T
Q
--
W
R
F
E
Y
S
P
E
---
S
Y
T
G
T
--
E
L
E
Y
A
K
Q
V
C
D
A
V
G
E
V
I
A
------
P
TPE
R
P
I
I
F
N
L
P
A
T
V
E
M
-
T
T
P
N
V
Y
A
D
S
I
E
W
-
M
S
R
N
L
-
A
N
R
E
S
V
I
L
S
L
H
P
H
N
D
R
G
T
A
V
A
A
A
E
L
G
F
A
A
G
A
D
R
I
E
G
C
L
F
G
N
G
E
R
T
G
N
V
C
L
V
T
L
G
L
N
L
F
S
R
G
V
D
P
Q
I
D
F
S
-
N
I
D
E
I
R
R
T
V
E
Y
C
N
Q
L
---
P
V
H
E
R
H
P
Y
G
G
D
L
V
Y
T
A
F
S
G
S
H
Q
D
A
I
N
K
G
L
D
A
M
K
L
D
A
D
A
A
DCDVDDML
W
Q
V
P
-
Y
L
P
I
D
P
R
D
V
G
-
R
T
Y
-
E
A
-----
V
I
-------
K
G
G
V
A
Y
I
M
K
T
D
H
G
L
S
-
L
P
R
R
L
Q
I
E
F
S
Q
--
V
I
Q
K
I
-----------
E
V
S
P
K
E
-
M
W
D
A
F
A
E
E
Y
L
A
P
VRPL
E
R
I
R
Q
H
V
D
A
A
D
D
D
G
G
T
T
S
I
-
T
A
T
V
K
I
N
G
V
E
T
----
E
I
S
G
S
G
N
G
P
L
A
A
F
V
H
A
L
A
D
-
V
G
F
D
V
A
V
L
D
Y
Y
E
H
A
-
M
S
A
G
D
D
A
Q
A
A
A
Y
V
E
A
SVTIA---
T
S
-
K
T
V
W
G
V
G
I
A
P
S
I
T
T
A
S
L
R
A
V
V
S
A
V
N
R
-------------------
17
PsiBlast_PDB
72.52
24%
3
- C2 -
3FIG
4
LEU1_MYCTU
A:
[81-643]
----------------------------------------------------------------
L
R
D
G
N
Q
A
L
I
D
P
M
S
P
-
A
R
K
R
R
M
F
-
D
-
L
L
V
R
M
-
G
Y
K
E
I
E
V
G
F
P
S
A
S
Q
T
D
F
D
F
V
R
E
I
I
E
Q
G
-
A
I
P
---
D
-
D
V
T
I
Q
V
L
T
Q
C
R
P
E
L
I
E
R
T
F
Q
A
C
S
G
A
P
R
A
I
V
H
F
Y
N
S
T
S
I
L
Q
R
R
V
V
F
R
A
N
R
A
E
V
Q
A
I
A
T
D
G
A
R
K
C
-----
V
E
Q
A
A
K
---
Y
---
P
-------
G
---
T
Q
--
W
R
F
E
Y
S
P
E
---
S
Y
T
G
T
--
E
L
E
Y
A
K
Q
V
C
D
A
V
G
E
V
I
A
------
P
TPE
R
P
I
I
F
N
L
P
A
T
V
E
M
-
T
T
P
N
V
Y
A
D
S
I
E
W
-
M
S
R
N
L
-
A
N
R
E
S
V
I
L
S
L
H
P
H
N
D
R
G
T
A
V
A
A
A
E
L
G
F
A
A
G
A
D
R
I
E
G
C
L
F
G
N
G
E
R
T
G
N
V
C
L
V
T
L
G
L
N
L
F
S
R
G
V
D
P
Q
I
D
F
S
-
N
I
D
E
I
R
R
T
V
E
Y
C
N
Q
L
---
P
V
H
E
R
H
P
Y
G
G
D
L
V
Y
T
A
F
S
G
S
H
Q
D
A
I
N
K
G
L
D
A
M
K
L
D
A
D
A
A
DCDVDDML
W
Q
V
P
-
Y
L
P
I
D
P
R
D
V
G
-
R
T
Y
-
E
A
-----
V
I
-------
K
G
G
V
A
Y
I
M
K
T
D
H
G
L
S
-
L
P
R
R
L
Q
I
E
F
S
Q
--
V
I
Q
K
I
-----------
E
V
S
P
K
E
-
M
W
D
A
F
A
E
E
Y
L
A
P
VRPL
E
R
I
R
Q
H
V
D
A
A
D
D
D
G
G
T
T
S
I
-
T
A
T
V
K
I
N
G
V
E
T
----
E
I
S
G
S
G
N
G
P
L
A
A
F
V
H
A
L
A
D
-
V
G
F
D
V
A
V
L
D
Y
Y
E
H
A
-
M
S
A
G
D
D
A
Q
A
A
A
Y
V
E
A
SVTIAS-----
K
T
V
W
G
V
G
I
A
P
S
I
T
T
A
S
L
R
A
V
V
S
A
V
N
R
-------------------
48
Fugue
72.49
35%
12
- C2 -
4OV4
2
?
A:
[23-408]
---------------------------------------------------
P
K
T
I
H
I
Q
---
D
V
T
L
R
D
G
N
Q
A
L
K
R
P
W
T
I
-
D
E
K
I
E
V
F
-
D
-
L
L
V
E
L
-
N
V
D
G
I
E
V
G
F
P
S
S
N
E
T
E
F
H
T
C
Q
V
L
---
S
-
K
R
A
P--
K
-
G
K
P
I
A
A
L
S
R
A
N
Q
N
E
I
A
V
T
W
E
A
I
Q
K
A
D
C
P
R
M
H
I
V
Y
P
V
S
D
F
S
I
K
H
V
L
K
I
S
E
K
E
V
L
Q
K
I
R
N
S
I
S
F
A
-----
R
S
---
I
---
V
GPG
I
-------
E
---
I
Q
--
F
----
S
G
E
HF-
G
D
A
I
E
--
N
F
A
F
T
K
E
A
F
L
T
A
I
E
A
G
A
------
N
------
I
I
N
L
P
N
T
V
E
R
-
Y
R
P
M
V
F
V
N
M
V
K
E
-
I
K
D
V
V
-
K
D
--
K
A
I
I
S
I
H
T
H
N
D
L
G
M
A
T
A
T
S
V
E
S
V
Y
V
G
A
E
Q
I
E
V
A
L
N
G
L
G
E
R
A
G
N
T
N
L
Y
E
T
A
I
A
L
H
Q
N
G
E
----
N
L
N
I
N
F
Q
R
I
Y
P
T
A
K
R
I
S
E
L
T
G
I
P
I
G
E
K
T
P
I
I
G
E
D
I
F
S
H
R
S
G
I
H
Q
H
---
Q
--------------------
S
K
G
A
-
Y
R
T
F
S
P
E
F
V
G
R
M
D
K
-
E
T
-----
I
S
F
-
T
N
Q
S
G
H
K
A
I
E
F
L
L
-
H
Q
R
G
I
Q
-
V
S
K
E
G
I
H
H
L
F
S
--
L
A
K
S
I
S
S
R
E
N
-
N
-
R
--
E
I
T
E
A
E
-
L
V
A
L
S
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
71.12
34%
6
- C2 -
4OV9
2
?
A:
[24-406]
----------------------------------------------------
K
T
I
H
I
Q
---
D
V
T
L
R
D
G
N
Q
A
L
K
R
P
W
T
I
-
D
E
K
I
E
V
F
-
D
-
L
L
V
E
L
-
N
V
D
G
I
E
V
G
F
P
S
S
N
E
T
E
F
H
T
C
Q
V
L
---
S
K
R
A
P
---
K
-
G
K
P
I
A
A
L
S
R
A
N
Q
N
E
I
A
V
T
W
E
A
I
Q
K
A
D
C
P
R
M
H
I
V
Y
P
V
S
D
F
S
I
K
H
V
L
K
I
S
E
K
E
V
L
Q
K
I
R
N
S
I
S
F
A
-----
R
S
---
I
---
V
---
G
-------
P
G
I
E
I
Q
--
F
----
S
G
E
HFG
D
A
I
E
N
---
F
A
F
T
K
E
A
F
L
T
A
I
E
A
G
A
------
N
------
I
I
N
L
P
N
T
V
E
R
-
Y
R
P
M
V
F
V
N
M
V
K
E
-
I
K
D
V
V
-
K
D
--
K
A
I
I
S
I
H
T
H
N
D
L
G
M
A
T
A
T
S
V
E
S
V
Y
V
G
A
E
Q
I
E
V
A
L
N
G
L
G
E
R
A
G
N
T
N
L
Y
E
T
A
I
A
L
H
Q
N
G
E
----
N
L
N
I
N
F
Q
R
I
Y
P
T
A
K
R
I
S
E
L
T
G
I
P
I
G
E
K
T
P
I
I
G
E
D
I
F
S
H
R
S
G
I
H
Q
-----T
L
H
Q
----------------
S
K
G
A
-
Y
R
T
F
S
P
E
F
V
G
R
M
D
K
-
E
T
-----
I
S
F
-
T
N
Q
S
G
H
K
A
I
E
F
L
L
-
H
Q
R
G
I
Q
-
V
S
K
E
G
I
H
H
L
F
S
--
L
A
K
S
I
S
S
R
E
N
-
N
-
R
--
E
I
T
E
A
E
-
L
V
A
L
---------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
70.52
27%
-90
- C2 -
3IVS
2
HOSM_SCHPO
A:
[37-409]
---------------------------------------------------
V
N
N
F
S
I
I
---
E
S
T
L
R
E
G
E
Q
F
A
N
A
F
F
D
T
-
E
K
K
I
Q
I
A
-
K
-
A
L
D
N
F
-
G
V
D
Y
I
E
L
T
S
P
V
A
S
E
Q
S
R
Q
D
C
E
A
I
---
C
-
K
L
G
---
L
-
K
C
K
I
L
T
H
I
R
C
H
M
D
D
A
R
V
A
V
E
----
T
G
V
D
G
V
D
V
V
I
G
T
-------------
T
Y
I
I
D
S
A
T
E
V
I
N
F
V
-----
K
S
---
K
---
G
---
I
-------
E
---
V
R
--
F
----
S
S
E
---
D
S
F
R
S
--
D
L
V
D
L
L
S
L
Y
K
A
V
D
K
I
G
V
------
N
------
R
V
G
I
A
D
T
V
G
C
-
A
T
P
R
Q
V
Y
D
L
I
R
T
-
L
R
G
V
V
-----
S
C
D
I
E
C
H
F
H
N
D
T
G
M
A
I
A
N
A
Y
C
A
L
E
A
G
A
T
H
I
D
T
S
I
L
G
I
G
E
R
N
G
I
T
P
L
G
A
L
L
A
R
M
Y
V
T
D
R
-
E
Y
I
T
H
K
Y
K
L
N
Q
L
R
E
L
E
N
L
V
A
D
A
V
E
V
Q
I
P
F
N
N
Y
I
T
G
M
C
A
F
T
H
K
A
G
I
H
A
K
A
I
L
A
--------------------
N
P
S
T
-
Y
E
I
L
K
P
E
D
F
G
-
M
S
R
--
Y
-----
V
H
V
G
S
R
L
T
G
W
N
A
I
K
S
R
A
-
E
Q
L
N
L
H
-
L
---
Q
A
K
E
L
T
V
--
R
I
K
K
L
A
---
V
-
R
----
T
L
A
M
D
D
-
V
D
R
V
L
R
E
Y
H
A
---------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
63.77
24%
23
- C2 -
1SR9
3
LEU1_MYCTU
A:
[18-643]
TIVKPAGPPRVGQPSWNP
Q
R
A
S
SMPVNRYRPFAEEVEPIRLRNRTWPDRVI
D
R
A
P
L
W
C
---
A
V
D
L
R
D
G
N
Q
A
L
I
---
D
P
M
S
P
A
R
K
R
R
M
F
-
D
L
L
V
R
M
G
Y
K
E
I
E
V
G
F
P
S
A
S
Q
T
D
F
D
F
V
R
E
I
---
I
-
E
Q
G
AIP
D
-
D
V
T
I
Q
V
L
T
Q
C
R
P
E
L
I
E
R
T
F
Q
A
C
S
G
A
P
R
A
I
V
H
F
Y
N
S
T
S
I
L
Q
R
R
V
V
F
R
A
N
R
A
E
V
Q
A
I
A
T
D
G
A
R
K
C
-----
V
E
---
Q
---
A
---
A
K
Y
PGTQ
W
R
---
F
E
--
Y
----
S
P
E
---
S
Y
T
G
T
--
E
L
E
Y
A
K
Q
V
C
D
A
V
G
E
V
I
A
PTPE
R
P
I
------
I
F
N
L
P
A
T
V
-
E
M
T
T
P
N
V
Y
A
D
S
I
E
W
M
S
R
-
N
L
-
A
N
R
E
S
V
I
L
S
L
H
P
H
N
D
R
G
T
A
V
A
A
A
E
L
G
F
A
A
G
A
D
R
I
E
G
C
L
F
G
N
G
E
R
T
G
N
V
C
L
V
T
L
G
L
N
L
F
S
R
G
----
V
D
P
Q
I
D
F
S
N
I
D
E
I
R
R
T
V
E
Y
C
N
Q
L
P
V
H
E
R
H
P
Y
G
G
D
L
V
Y
T
A
F
S
G
S
H
Q
D
A
I
N
K
--------------------
G
L
D
A
M
K
L
D
A
D
A
A
D
C
D
-
V
D
D
M
L
W
Q
V
P
YL
P
I
D
-
P
R
D
V
G
R
T
Y
E
A
V
I
K
-
G
G
V
A
Y
I
M
K
T
D
H
G
L
S
L
P
R
R
--
L
Q
I
E
F
S
--
Q
V
-
I
-
Q
K
I
E
V
S
P
K
E
M
W
D
A
F
A
E
E
Y
L
A
P
V
----
R
P
L
E
R
I
R
Q
H
V
D
A
A
D
D
D
G
G
T
T
S
I
T
A
T
V
K
I
--
N
G
V
E
T
E
I
S
G
S
G
N
G
P
L
A
A
F
V
H
A
L
A
D
-
V
G
F
D
V
A
V
L
D
Y
Y
E
H
A
M
S
-
A
G
D
D
A
Q
A
A
A
Y
V
E
A
------
S
V
T
I
S
K
T
V
W
G
V
G
I
A
P
S
I
T
T
A
S
L
R
A
V
V
S
A
V
N
R
A
A
-----------------
9
PsiBlast_PDB
61.23
29%
-7
- C2 -
3A9I
2
HOSC_THET2
A:
[2-375]
----------------------------------------------------
R
E
W
K
I
I
---
D
S
T
L
R
E
G
E
Q
F
E
K
A
N
F
S
T
-
Q
D
K
V
E
I
A
-
K
-
A
L
D
E
F
-
G
I
E
Y
I
E
V
T
T
P
V
A
S
P
Q
S
R
K
D
A
E
V
L
---
A
-
S
L
G
---
L
-
K
A
K
V
V
T
H
I
Q
C
---
R
L
D
A
A
K
V
A
V
E
T
G
V
Q
G
I
D
L
L
F
G
T
S
K
Y
L
------
D
I
P
R
--
I
I
E
E
A
K
E
V
I
A
Y
I
-----
R
E
---
A
---
A
---
P
-------
H
---
V
E
V
R
F
----
S
A
E
---
D
T
F
R
S
--
E
E
Q
D
L
L
A
V
Y
E
A
V
A
P
Y
-
V
------
D
------
R
V
G
L
A
D
T
V
G
V
-
A
T
P
R
Q
V
Y
A
L
V
R
E
-
V
R
R
V
V
G
P
R
V
---
D
I
E
F
H
G
H
N
D
T
G
C
A
I
A
N
A
Y
E
A
I
E
A
G
A
T
H
V
D
T
T
I
L
G
I
G
E
R
N
G
I
T
P
L
G
G
F
L
A
R
M
Y
T
L
Q
P
E
Y
-
V
R
R
K
Y
K
L
E
M
L
P
E
L
D
R
M
V
A
R
M
V
G
V
E
I
P
F
N
N
Y
I
T
G
E
T
A
F
S
H
K
A
G
M
H
L
K
A
I
Y
I
--------------------
N
P
E
A
-
Y
E
P
Y
P
P
E
V
F
G
-
V
K
------------------------------
G
L
H
-
Y
G
E
E
E
L
H
R
V
T
Q
--
H
I
K
A
L
A
--
D
--
R
-
G
--
Q
L
T
L
E
E
-
L
-
D
R
I
L
R
E
W
I
T
--------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
59.42
28%
-2
- C2 -
3HPX
3
LEU1_MYCTU
A:
[79-385]
----------------------------------------------------------------
L
R
D
G
N
Q
A
L
I
D
P
M
S
P
-
A
R
K
R
R
M
F
-
D
-
L
L
V
R
M
-
G
Y
K
E
I
E
V
G
F
P
S
A
S
Q
T
D
F
D
F
V
R
E
I
I
E
Q
G
-
A
I
P
---
D
-
D
V
T
I
Q
V
L
T
Q
C
R
P
E
L
I
E
R
T
F
Q
A
C
S
G
A
P
R
A
I
V
H
F
Y
N
S
T
S
I
L
Q
R
R
V
V
F
R
A
N
R
A
E
V
Q
A
I
A
T
D
G
A
R
K
C
-----
V
E
Q
A
A
K
---
Y
---
P
-------
G
---
T
Q
--
W
R
F
E
Y
S
P
E
---
S
Y
T
G
T
--
E
L
E
Y
A
K
Q
V
C
D
A
V
G
E
V
I
A
------
P
TPER
P
I
I
F
N
L
P
A
T
V
E
M
-
T
T
P
N
V
Y
A
D
S
I
E
W
-
M
S
R
N
L
-
A
N
R
E
S
V
I
L
S
L
H
P
H
N
D
R
G
T
A
V
A
A
A
E
L
G
F
A
A
G
A
D
R
I
E
G
C
L
F
G
N
G
E
R
T
G
N
V
C
L
V
T
L
G
L
N
L
F
S
R
G
V
D
P
Q
I
D
F
S
-
N
I
D
E
I
R
R
T
V
E
Y
C
N
Q
L
---
P
V
H
E
R
H
P
Y
G
G
D
L
V
Y
T
A
F
S
G
S
H
Q
D
A
I
N
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
58.02
28%
2
- C2 -
3MI3
4
HOSM_SCHPO
A:
[34-391]
---------------------------------------------------
L
S
R
V
N
N
F
S
I
I
E
S
T
L
R
E
G
E
Q
F
A
N
A
F
F
D
T
-
E
K
K
I
Q
I
A
-
K
-
A
L
D
N
F
-
G
V
D
Y
I
E
L
T
S
P
V
A
S
E
Q
S
R
Q
D
C
E
A
I
---
C
-
K
L
G
---
L
-
K
C
K
I
L
T
H
I
R
C
H
M
D
D
A
R
V
A
V
E
T
G
V
D
G
----
V
D
V
V
I
G
T
S
-----------
M
T
Y
I
I
D
S
A
T
E
V
I
N
F
V
-----
K
S
---
K
---
G
---
I
-------
E
---
V
R
--
F
----
S
S
E
---
D
S
F
R
S
--
D
L
V
D
L
L
S
L
Y
K
A
V
D
K
I
G
V
------
N
------
R
V
G
I
A
D
T
V
G
C
-
A
T
P
R
Q
V
Y
D
L
I
R
T
-
L
R
-----
G
V
V
S
C
D
I
E
C
H
F
H
N
D
T
G
M
A
I
A
N
A
Y
C
A
L
E
A
G
A
T
H
I
D
T
S
I
L
G
I
G
E
R
N
G
I
T
P
L
G
A
L
L
A
R
M
Y
V
T
D
R
E
Y
-
I
T
H
K
Y
K
L
N
Q
L
R
E
L
E
N
L
V
A
D
A
V
E
V
Q
I
P
F
N
N
Y
I
T
G
M
C
A
F
T
H
K
A
G
I
H
A
K
A
I
L
A
--------------------
N
P
S
T
-
Y
E
I
L
K
P
E
D
F
G
-
M
S
R
-
Y
V
-----
H
V
G
-
S
R
L
T
G
W
N
A
I
K
S
R
-----------
A
E
Q
L
N
L
H
L
T
D
A
Q
A
K
E
L
T
--
V
R
-
I
-
K
--
K
L
A
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
57.51
28%
6
- C2 -
3IVU
3
HOSM_SCHPO
A:
[34-391]
---------------------------------------------------
L
S
R
V
N
N
F
S
I
I
E
S
T
L
R
E
G
E
Q
F
A
N
A
F
F
D
T
-
E
K
K
I
Q
I
A
-
K
-
A
L
D
N
F
-
G
V
D
Y
I
E
L
T
S
P
V
A
S
E
Q
S
R
Q
D
C
E
A
I
---
C
-
K
L
G
---
L
-
K
C
K
I
L
T
H
I
R
C
H
M
D
D
A
R
V
A
V
E
T
G
V
D
G
----
V
D
V
V
I
G
T
S
Q
Y
L
R
K
Y
S
H
--
D
M
T
Y
I
I
D
S
A
T
E
V
I
N
F
V
-----
K
S
---
K
---
G
---
I
-------
E
---
V
R
--
F
----
S
S
E
---
D
S
F
R
S
--
D
L
V
D
L
L
S
L
Y
K
A
V
D
K
I
G
V
------
N
------
R
V
G
I
A
D
T
V
G
C
-
A
T
P
R
Q
V
Y
D
L
I
R
T
-
L
R
-----
G
V
V
S
C
D
I
E
C
H
F
H
N
D
T
G
M
A
I
A
N
A
Y
C
A
L
E
A
G
A
T
H
I
D
T
S
I
L
G
I
G
E
R
N
G
I
T
P
L
G
A
L
L
A
R
M
Y
V
T
D
R
E
Y
-
I
T
H
K
Y
K
L
N
Q
L
R
E
L
E
N
L
V
A
D
A
V
E
V
Q
I
P
F
N
N
Y
I
T
G
M
C
A
F
T
H
K
A
G
I
-----------------------------
S
T
-
Y
E
I
L
K
P
E
D
F
G
-
M
S
R
-
Y
V
-----
H
V
G
-
S
R
L
T
G
W
N
A
I
K
S
R
-----------
A
E
Q
L
N
L
H
L
T
D
A
Q
A
K
E
L
T
--
V
R
-
I
-
K
--
K
L
A
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
57.28
29%
-12
- C2 -
2ZYF
2
HOSC_THET2
A:
[1-320]
---------------------------------------------------
M
R
E
W
K
I
I
---
D
S
T
L
R
E
G
E
Q
F
E
K
A
N
F
S
T
-
Q
D
K
V
E
I
A
-
K
-
A
L
D
E
F
-
G
I
E
Y
I
E
V
T
T
P
V
A
S
P
Q
S
R
K
D
A
E
V
L
---
A
-
S
L
G
---
L
-
K
A
K
V
V
T
H
I
Q
C
---
R
L
D
A
A
K
V
A
V
E
T
G
V
Q
G
I
D
L
L
F
G
T
S
K
------
G
R
D
I
P
R
--
I
I
E
E
A
K
E
V
I
A
Y
I
-----
R
E
---
A
---
A
---
P
-------
H
---
V
E
V
R
F
----
S
A
E
---
D
T
F
R
S
--
E
E
Q
D
L
L
A
V
Y
E
A
V
A
P
Y
-
V
------
D
------
R
V
G
L
A
D
T
V
G
V
-
A
T
P
R
Q
V
Y
A
L
V
R
E
-
V
R
R
V
V
G
P
R
V
---
D
I
E
F
H
G
H
N
D
T
G
C
A
I
A
N
A
Y
E
A
I
E
A
G
A
T
H
V
D
T
T
I
L
G
I
G
E
R
N
G
I
T
P
L
G
G
F
L
A
R
M
Y
T
L
Q
P
E
Y
-
V
R
R
K
Y
K
L
E
M
L
P
E
L
D
R
M
V
A
R
M
V
G
V
E
I
P
F
N
N
Y
I
T
G
E
T
A
F
S
H
K
A
G
M
H
L
K
A
I
Y
I
--------------------
N
P
E
A
-
Y
E
P
Y
P
P
E
V
F
G
-
V
K
R
-
K
L
-----
I
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
56.09
28%
5
- C2 -
3IVT
3
HOSM_SCHPO
A:
[34-391]
---------------------------------------------------
L
S
R
V
N
N
F
S
I
I
E
S
T
L
R
E
G
E
Q
F
A
N
A
F
F
D
T
-
E
K
K
I
Q
I
A
-
K
-
A
L
D
N
F
-
G
V
D
Y
I
E
L
T
S
P
V
A
S
E
Q
S
R
Q
D
C
E
A
I
---
C
-
K
L
G
---
L
-
K
C
K
I
L
T
H
I
R
C
H
M
D
D
A
R
V
A
V
E
T
G
V
D
G
----
V
D
V
V
I
G
T
S
Q
Y
L
R
K
Y
S
H
G
K
D
M
T
Y
I
I
D
S
A
T
E
V
I
N
F
V
-----
K
S
---
K
---
G
---
I
-------
E
---
V
R
--
F
----
S
S
E
---
D
S
F
R
S
--
D
L
V
D
L
L
S
L
Y
K
A
V
D
K
I
G
V
------
N
------
R
V
G
I
A
D
T
V
G
C
-
A
T
P
R
Q
V
Y
D
L
I
R
T
-
L
R
-----
G
V
V
S
C
D
I
E
C
H
F
H
N
D
T
G
M
A
I
A
N
A
Y
C
A
L
E
A
G
A
T
H
I
D
T
S
I
L
G
I
G
E
R
N
G
I
T
P
L
G
A
L
L
A
R
M
Y
V
T
D
R
E
Y
-
I
T
H
K
Y
K
L
N
Q
L
R
E
L
E
N
L
V
A
D
A
V
E
V
Q
I
P
F
N
N
Y
I
T
G
M
C
A
F
T
H
K
A
G
I
H
A
K
A
I
L
A
--------------------
N
P
S
T
-
Y
E
I
L
K
P
E
D
F
G
-
M
S
R
-
Y
V
-----
H
V
G
-
S
R
L
T
G
W
N
A
I
K
S
R
-----------
A
E
Q
L
N
L
H
L
T
D
A
Q
A
K
E
L
T
--
V
R
-
I
-
K
--
K
L
A
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
54.02
30%
28
- C2 -
3BLF
2
?
A:
[19-334]
-----------------------------------------------------
R
L
E
I
L
---
D
V
T
L
R
D
G
E
Q
T
R
G
V
S
F
S
T
-
S
E
K
L
N
I
A
-
K
F
L
L
Q
K
L
-
N
V
D
R
V
E
I
A
S
A
R
V
S
K
G
E
L
E
T
V
Q
K
I
M
E
W
A
-
A
T
E
---
Q
-
L
T
E
R
I
E
I
L
G
F
V
D
G
N
K
T
V
D
W
--
I
K
D
S
G
A
K
V
L
N
L
L
T
K
G
S
L
H
H
L
E
K
Q
L
G
K
T
P
K
E
F
F
T
D
V
S
F
V
I
E
Y
A
I
K
S
G
L
K
I
---
N
---
V
---
Y
-------
L
---
E
D
--
W
----
S
-----
N
G
F
R
N
--
S
P
D
Y
V
K
S
L
V
E
H
L
S
K
E
H
I
------
E
------
R
I
F
L
P
D
T
L
G
V
-
L
S
P
E
E
T
F
Q
G
V
D
S
-
L
I
Q
K
Y
-
P
D
I
H
---
F
E
F
H
G
H
N
D
Y
D
L
S
V
A
N
S
L
Q
A
I
R
A
G
V
K
G
L
H
A
S
I
N
G
L
G
E
R
A
G
N
T
P
L
E
A
L
V
T
T
I
H
D
K
S
N
---
S
K
T
N
I
N
E
I
A
I
T
E
A
S
R
L
V
E
V
F
S
G
K
R
I
S
A
N
R
P
I
V
G
E
D
V
F
T
---------------------------------
N
L
Y
-
A
N
P
I
L
P
E
R
F
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
52.95
30%
29
- C2 -
3BLI
3
?
A:
[19-334]
-----------------------------------------------------
R
L
E
I
L
---
D
V
T
L
R
D
G
E
Q
T
R
G
V
S
F
S
T
-
S
E
K
L
N
I
A
-
K
F
L
L
Q
K
L
-
N
V
D
R
V
E
I
A
S
A
R
V
S
K
G
E
L
E
T
V
Q
K
I
M
E
W
A
-
A
T
E
---
Q
-
L
T
E
R
I
E
I
L
G
F
V
D
G
N
K
T
V
D
W
--
I
K
D
S
G
A
K
V
L
N
L
L
T
K
G
S
L
H
H
L
E
K
Q
L
G
K
T
P
K
E
F
F
T
D
V
S
F
V
I
E
Y
A
I
K
S
G
L
K
I
---
N
---
V
---
Y
-------
L
---
E
D
--
W
----
S
-----
N
G
F
R
N
--
S
P
D
Y
V
K
S
L
V
E
H
L
S
K
E
H
I
------
E
------
R
I
F
L
P
D
T
L
G
V
-
L
S
P
E
E
T
F
Q
G
V
D
S
-
L
I
Q
K
Y
-
P
D
I
H
---
F
E
F
H
G
H
N
D
Y
D
L
S
V
A
N
S
L
Q
A
I
R
A
G
V
K
G
L
H
A
S
I
N
G
L
G
E
R
A
G
N
T
P
L
E
A
L
V
T
T
I
H
D
K
S
N
---
S
K
T
N
I
N
E
I
A
I
T
E
A
S
R
L
V
E
V
F
S
G
K
R
I
S
A
N
R
P
I
V
G
E
D
V
F
T
Q
T
A
G
V
----------------------------
N
L
Y
-
A
N
P
I
L
P
E
R
F
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------