@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu28290: (2016-07-14 )
MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVIVGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKSLVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEARDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGYQPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKEVLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKEAVVSVAQN
Atome Classification :
(26 SA)
.........10........20........30........------40......------..-----50.-.-.-....-----..60........70........80........-90........100.......110...---....120.......130.......140.-----......150.......160.......170..-------------------.-------------------------------------------------------------...---------------.-------180..------------------------------------------......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300........310.......320...-.-...330.......340
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
K
V
Y
YNGDIKENVLAG
K
T
V
A
V
I
G
YGSQGH
A
H
A
LNLKES------GV
D
V
I
V
G
V------RQ-----G-K-S-F-
T
Q
A
Q-----EDG
H
K
V
F
S
V
K
EAAAQ
A
E
I
I
M
V
LLP
D
E
Q
Q
Q
K
V
Y
-
E
A
E
I
K
D
E
LTAGK
S
L
V
F
A
HGF
N
V
H
F
H
Q---IVPPADV
D
V
F
L
V
APKGP
G
H
L
V
R
R
T
Y
E
QG-----AG
V
P
A
L
F
A
I
Y
Q
DVTGEAR
D
K
A
L
A
Y
AKGIGGA-------------------R-------------------------------------------------------------AG
V
---------------
L
-------
E
T
-
T
F------------------------------------------KEETETDLFG
E
Q
A
V
L
C
G
G
L
S
A
L
V
K
A
G
F
E
T
L
T
EAGYQP
E
L
A
Y
F
E
C
L
H
E
L
K
L
I
V
D
L
M
Y
EEGLAG
M
R
YSISDTAQWGDFVSG
P
R
V
V
D
A
K
V
K
E
S
M
K
E
V
L
K
D
I
QNGT
F
A
K
E
W
I
V
ENQVNRPR-FNAINASEN
E
H
Q
I
E
V
V
G
R
K
L
R
E
M
M
P
-
F
-
V
KQGKK
K
E
A
V
VSVAQN
1
PsiBlast_PDB
82.33
69%
-114
- C4 -
4TSK
5
?
A:
[2-328]
-
E
K
I
Y
Y
D
A
D
I
S
I
Q
P
L
A
D
K
R
I
A
V
I
G
Y
G
S
Q
G
H
A
H
A
Q
N
L
R
D
S
------
G
F
D
V
V
I
G
L
------
R
P
-----
G
-
S
-
S
-
W
-
A
K
A
E
-----
A
D
G
F
R
V
M
A
V
G
E
A
V
E
E
S
D
V
I
M
I
L
L
P
D
E
R
Q
P
A
V
Y
-
E
R
E
I
R
P
Y
L
T
A
G
K
A
L
A
F
A
H
G
F
N
I
H
F
S
Q
---
I
Q
P
P
K
D
V
D
V
F
M
V
A
P
K
G
P
G
H
L
V
R
R
V
Y
E
A
G
-----
G
G
V
P
A
L
I
A
V
H
Q
D
A
S
G
Q
A
K
D
L
A
L
A
Y
A
R
G
I
G
A
G
-------------------
R
-------------------------------------------------------------
A
G
I
---------------
L
-------
T
T
-
T
F
------------------------------------------
R
E
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
L
S
A
L
I
K
A
G
F
E
T
L
V
E
A
G
Y
Q
P
E
I
A
Y
F
E
C
L
H
E
M
K
L
I
V
D
L
I
Y
E
G
G
L
E
Y
M
R
Y
S
I
S
D
T
A
Q
W
G
D
F
T
S
G
P
R
I
I
N
E
E
T
K
K
E
M
R
R
I
L
A
D
I
Q
S
G
A
F
A
K
S
W
I
L
E
N
Q
A
N
R
P
M
-
F
N
A
I
N
R
R
E
L
E
H
P
I
E
V
V
G
R
K
L
R
S
M
M
P
-
F
-
I
K
--------------
6
PsiBlast_PDB
82.31
55%
0
- C- -
5E4R
6
?
A:
[2-334]
-
A
K
I
Y
K
D
E
D
I
S
L
E
P
I
K
N
K
T
I
A
I
L
G
Y
G
S
Q
G
R
A
W
A
L
N
L
R
D
S
------
G
L
N
V
V
V
G
L
E-----
R
Q
-----
G
-
D
-
S
-
W
-
R
R
A
I
-----
D
D
G
F
K
P
M
Y
T
K
D
A
V
A
I
A
D
I
I
V
F
L
V
P
D
M
V
Q
K
S
L
W
-
L
N
S
V
K
D
F
M
K
K
G
A
D
L
V
F
A
H
G
F
N
I
H
F
K
I
---
I
E
P
P
K
D
S
D
V
Y
M
I
A
P
K
S
P
G
P
I
V
R
R
S
Y
E
M
G
-----
G
G
V
P
A
L
V
A
V
Y
Q
N
V
S
G
E
A
L
Q
K
A
L
A
I
A
K
G
I
G
C
A
-------------------
R
-------------------------------------------------------------
A
G
V
---------------
I
-------
E
S
-
T
F
------------------------------------------
K
E
E
T
E
T
D
L
F
G
E
Q
V
I
L
V
G
G
I
M
E
L
I
K
A
S
F
E
T
L
V
E
E
G
Y
Q
P
E
V
A
Y
F
E
T
V
N
E
L
K
L
I
V
D
L
I
Y
E
K
G
L
T
G
M
L
R
A
V
S
D
T
A
K
Y
G
G
I
T
V
G
K
F
I
I
D
K
S
V
R
D
K
M
K
I
V
L
E
R
I
R
S
G
E
F
A
R
E
W
I
K
E
Y
E
R
G
M
P
T
V
F
K
E
L
S
E
L
E
G
-
S
T
I
E
T
V
G
R
K
L
R
E
M
M
--------------------
111
HHSearch
77.12
68%
-51
- C4 -
4TSK
5
?
A:
[2-334]
-
E
K
I
Y
Y
D
A
D
I
S
I
Q
P
L
A
D
K
R
I
A
V
I
G
Y
G
S
Q
G
H
A
H
A
Q
N
L
R
D
S
------
G
F
D
V
V
I
G
L
------
R
P
-----
G
-
S
-
S
-
W
-
A
K
A
E
-----
A
D
G
F
R
V
M
A
V
G
E
A
V
E
E
S
D
V
I
M
I
L
L
P
D
E
R
Q
P
A
V
Y
E
R
-
E
I
R
P
Y
L
T
A
G
K
A
L
A
F
A
H
G
F
N
I
H
F
S
Q
---
I
Q
P
P
K
D
V
D
V
F
M
V
A
P
K
G
P
G
H
L
V
R
R
V
Y
E
A
G
-----
G
G
V
P
A
L
I
A
V
H
Q
D
A
S
G
Q
A
K
D
L
A
L
A
Y
A
R
G
I
G
A
G
-------------------
R
-------------------------------------------------------------
A
G
I
---------------
L
-------
T
T
-
T
F
------------------------------------------
R
E
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
L
S
A
L
I
K
A
G
F
E
T
L
V
E
A
G
Y
Q
P
E
I
A
Y
F
E
C
L
H
E
M
K
L
I
V
D
L
I
Y
E
G
G
L
E
Y
M
R
Y
S
I
S
D
T
A
Q
W
G
D
F
T
S
G
P
R
I
I
N
E
E
T
K
K
E
M
R
R
I
L
A
D
I
Q
S
G
A
F
A
K
S
W
I
L
E
N
Q
A
N
R
P
M
-
F
N
A
I
N
R
R
E
L
E
H
P
I
E
V
V
G
R
K
L
R
S
M
M
P
-
F
-
I
K
A
K
R
P
G
D
--------
3
PsiBlast_PDB
73.04
55%
-53
- C4 -
1NP3
-
ILVC_PSEAE
A:
[1-327]
-
M
R
V
F
Y
D
K
D
C
D
L
S
I
I
Q
G
K
K
V
A
I
I
G
Y
G
S
Q
G
H
A
H
A
C
N
L
K
D
S
------
G
V
D
V
T
V
G
L
------
R
S
-----
G
-
S
A
T
-
V
-
A
K
A
E
-----
A
H
G
L
K
V
A
D
V
K
T
A
V
A
A
A
D
V
V
M
I
L
T
P
D
E
F
Q
G
R
L
Y
-
K
E
E
I
E
P
N
L
K
K
G
A
T
L
A
F
A
H
G
F
S
I
H
Y
N
Q
---
V
V
P
R
A
D
L
D
V
I
M
I
A
P
K
A
P
G
H
T
V
R
S
E
F
V
K
G
-----
G
G
I
P
D
L
I
A
I
Y
Q
D
A
S
G
N
A
K
N
V
A
L
S
Y
A
C
G
V
G
G
G
-------------------
R
-------------------------------------------------------------
T
G
I
---------------
I
-------
E
T
-
T
F
------------------------------------------
K
D
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
C
V
E
L
V
K
A
G
F
E
T
L
V
E
A
G
Y
A
P
E
M
A
Y
F
E
C
L
H
E
L
K
L
I
V
D
L
M
Y
E
G
G
I
A
N
M
N
Y
S
I
S
N
N
A
E
Y
G
E
Y
V
T
G
P
E
V
I
N
A
E
S
R
A
A
M
R
N
A
L
K
R
I
Q
D
G
E
Y
A
K
M
F
I
T
E
G
A
A
N
Y
P
S
-
M
T
A
Y
R
R
N
N
A
A
H
P
I
E
Q
I
G
E
K
L
R
A
M
M
P
-
W
-
I
---------------
128
Fugue
73.03
56%
-53
- C4 -
1NP3
-
ILVC_PSEAE
A:
[1-327]
-
M
R
V
F
Y
D
K
D
C
D
L
S
I
I
Q
G
K
K
V
A
I
I
G
Y
G
S
Q
G
H
A
H
A
C
N
L
K
D
S
------
G
V
D
V
T
V
G
L
------
R
S
-----
G
S
A
-
T
-
V
-
A
K
A
E
-----
A
H
G
L
K
V
A
D
V
K
T
A
V
A
A
A
D
V
V
M
I
L
T
P
D
E
F
Q
G
R
L
Y
-
K
E
E
I
E
P
N
L
K
K
G
A
T
L
A
F
A
H
G
F
S
I
H
Y
N
Q
---
V
V
P
R
A
D
L
D
V
I
M
I
A
P
K
A
P
G
H
T
V
R
S
E
F
V
K
G
-----
G
G
I
P
D
L
I
A
I
Y
Q
D
A
S
G
N
A
K
N
V
A
L
S
Y
A
C
G
V
G
G
G
-------------------
R
-------------------------------------------------------------
T
G
I
---------------
I
-------
E
T
-
T
F
------------------------------------------
K
D
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
C
V
E
L
V
K
A
G
F
E
T
L
V
E
A
G
Y
A
P
E
M
A
Y
F
E
C
L
H
E
L
K
L
I
V
D
L
M
Y
E
G
G
I
A
N
M
N
Y
S
I
S
N
N
A
E
Y
G
E
Y
V
T
G
P
E
V
I
N
A
E
S
R
A
A
M
R
N
A
L
K
R
I
Q
D
G
E
Y
A
K
M
F
I
T
E
G
A
A
N
Y
P
S
-
M
T
A
Y
R
R
N
N
A
A
H
P
I
E
Q
I
G
E
K
L
R
A
M
M
P
-
W
-
I
---------------
4
PsiBlast_PDB
71.78
55%
-49
- C4 -
4KQW
8
?
A:
[13-338]
--
T
I
L
Y
E
Q
D
V
D
P
K
V
I
Q
G
L
K
V
G
I
I
G
Y
G
S
Q
G
H
A
H
A
L
N
L
M
D
S
------
G
V
D
V
R
V
G
L
------
R
E
-----
G
-
S
-
S
S
W
-
K
T
A
E
-----
E
A
G
L
K
V
T
D
M
D
T
A
A
E
E
A
D
V
I
M
V
L
V
P
D
E
I
Q
P
K
V
Y
-
Q
E
H
I
A
A
H
L
K
A
G
N
T
L
A
F
A
H
G
F
N
I
H
Y
G
Y
---
I
V
P
P
E
D
V
N
V
I
M
C
A
P
K
G
P
G
H
I
V
R
R
Q
F
T
E
G
-----
S
G
V
P
D
L
A
C
V
Q
Q
D
A
T
G
N
A
W
D
I
V
L
S
Y
C
W
G
V
G
G
A
-------------------
R
-------------------------------------------------------------
S
G
I
---------------
I
-------
K
A
-
T
F
------------------------------------------
A
E
E
T
E
E
D
L
F
G
E
Q
A
V
L
C
G
G
L
V
E
L
V
K
A
G
F
E
T
L
T
E
A
G
Y
P
P
E
L
A
Y
F
E
C
Y
H
E
M
K
M
I
V
D
L
M
Y
E
S
G
I
H
F
M
N
Y
S
I
S
N
T
A
E
Y
G
E
Y
Y
A
G
P
K
V
I
N
E
Q
S
R
E
A
M
K
E
I
L
K
R
I
Q
D
G
S
F
A
Q
E
F
V
D
D
C
N
N
G
H
K
R
-
L
L
E
Q
R
E
A
I
N
T
H
P
I
E
T
T
G
A
Q
I
R
S
M
F
S
-
W
-
I
---------------
22
PsiBlast_CBE
71.77
56%
-47
- C4 -
4XIY
5
ILVC_AZOVD
C:
[1-328]
-
M
K
V
Y
Y
D
K
D
C
D
L
S
I
I
Q
S
K
K
V
A
I
I
G
Y
G
S
Q
G
H
A
H
A
C
N
L
K
D
S
------
G
V
D
V
Y
V
G
L
------
R
A
-----
G
-
S
A
S
-
V
-
A
K
A
E
-----
A
H
G
L
T
V
K
S
V
K
D
A
V
A
A
A
D
V
V
M
I
L
T
P
D
E
F
Q
G
R
L
Y
-
K
D
E
I
E
P
N
L
K
K
G
A
T
L
A
F
A
H
G
F
S
I
H
Y
N
Q
---
V
V
P
R
A
D
L
D
V
I
M
I
A
P
K
A
P
G
H
T
V
R
S
E
F
V
R
G
-----
G
G
I
P
D
L
I
A
V
Y
Q
D
A
S
G
N
A
K
N
L
A
L
S
Y
A
C
G
V
G
G
G
-------------------
R
-------------------------------------------------------------
T
G
I
---------------
I
-------
E
T
-
T
F
------------------------------------------
K
D
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
C
V
E
L
V
K
A
G
F
E
T
L
V
E
A
G
Y
A
P
E
M
A
Y
F
E
C
L
H
E
L
K
L
I
V
D
L
M
F
E
G
G
I
A
N
M
N
Y
S
I
S
N
N
A
E
Y
G
E
Y
V
T
G
P
E
V
I
N
E
Q
S
R
Q
A
M
R
N
A
L
K
R
I
Q
D
G
E
Y
A
K
M
F
I
T
E
G
A
A
N
Y
P
S
-
M
T
A
Y
R
R
N
N
A
A
H
Q
I
E
V
V
G
E
K
L
R
T
M
M
P
-
W
-
I
A
--------------
21
PsiBlast_CBE
71.31
56%
-50
- C4 -
4XIY
4
ILVC_AZOVD
D:
[1-328]
-
M
K
V
Y
Y
D
K
D
C
D
L
S
I
I
Q
S
K
K
V
A
I
I
G
Y
G
S
Q
G
H
A
H
A
C
N
L
K
D
S
------
G
V
D
V
Y
V
G
L
------
R
A
-----
G
-
S
A
S
-
V
-
A
K
A
E
-----
A
H
G
L
T
V
K
S
V
K
D
A
V
A
A
A
D
V
V
M
I
L
T
P
D
E
F
Q
G
R
L
Y
-
K
D
E
I
E
P
N
L
K
K
G
A
T
L
A
F
A
H
G
F
S
I
H
Y
N
Q
---
V
V
P
R
A
D
L
D
V
I
M
I
A
P
K
A
P
G
H
T
V
R
S
E
F
V
R
G
-----
G
G
I
P
D
L
I
A
V
Y
Q
D
A
S
G
N
A
K
N
L
A
L
S
Y
A
C
G
V
G
G
G
-------------------
R
-------------------------------------------------------------
T
G
I
---------------
I
-------
E
T
-
T
F
------------------------------------------
K
D
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
C
V
E
L
V
K
A
G
F
E
T
L
V
E
A
G
Y
A
P
E
M
A
Y
F
E
C
L
H
E
L
K
L
I
V
D
L
M
F
E
G
G
I
A
N
M
N
Y
S
I
S
N
N
A
E
Y
G
E
Y
V
T
G
P
E
V
I
N
E
Q
S
R
Q
A
M
R
N
A
L
K
R
I
Q
D
G
E
Y
A
K
M
F
I
T
E
G
A
A
N
Y
P
S
-
M
T
A
Y
R
R
N
N
A
A
H
Q
I
E
V
V
G
E
K
L
R
T
M
M
P
-
W
-
I
A
--------------
115
HHSearch
71.24
54%
-48
- C4 -
4KQW
8
?
A:
[13-338]
--
T
I
L
Y
E
Q
D
V
D
P
K
V
I
Q
G
L
K
V
G
I
I
G
Y
G
S
Q
G
H
A
H
A
L
N
L
M
D
S
------
G
V
D
V
R
V
G
L
------
R
E
-----
G
-
S
-
S
-
S
W
K
T
A
E
-----
E
A
G
L
K
V
T
D
M
D
T
A
A
E
E
A
D
V
I
M
V
L
V
P
D
E
I
Q
P
K
V
Y
-
Q
E
H
I
A
A
H
L
K
A
G
N
T
L
A
F
A
H
G
F
N
I
H
Y
G
Y
---
I
V
P
P
E
D
V
N
V
I
M
C
A
P
K
G
P
G
H
I
V
R
R
Q
F
T
E
G
-----
S
G
V
P
D
L
A
C
V
Q
Q
D
A
T
G
N
A
W
D
I
V
L
S
Y
C
W
G
V
G
G
A
-------------------
R
-------------------------------------------------------------
S
G
I
---------------
I
-------
K
A
-
T
F
------------------------------------------
A
E
E
T
E
E
D
L
F
G
E
Q
A
V
L
C
G
G
L
V
E
L
V
K
A
G
F
E
T
L
T
E
A
G
Y
P
P
E
L
A
Y
F
E
C
Y
H
E
M
K
M
I
V
D
L
M
Y
E
S
G
I
H
F
M
N
Y
S
I
S
N
T
A
E
Y
G
E
Y
Y
A
G
P
K
V
I
N
E
Q
S
R
E
A
M
K
E
I
L
K
R
I
Q
D
G
S
F
A
Q
E
F
V
D
D
C
N
N
G
H
K
R
-
L
L
E
Q
R
E
A
I
N
T
H
P
I
E
T
T
G
A
Q
I
R
S
M
F
S
-
W
-
I
---------------
25
PsiBlast_CBE
70.96
55%
-48
- C4 -
4KQX
11
?
B:
[12-340]
-
V
T
I
L
Y
E
Q
D
V
D
P
K
V
I
Q
G
L
K
V
G
I
I
G
Y
G
S
Q
G
H
A
H
A
L
N
L
M
D
S
------
G
V
D
V
R
V
G
L
------
R
E
-----
G
-
D
-
S
D
W
-
K
T
A
E
-----
E
A
G
L
K
V
T
D
M
D
T
A
A
E
E
A
D
V
I
M
V
L
V
P
D
E
V
Q
P
K
V
Y
-
Q
E
H
I
A
A
H
L
K
A
G
N
T
L
A
F
A
H
G
F
N
I
H
Y
G
Y
---
I
V
P
P
E
D
V
N
V
I
M
C
A
P
K
G
P
G
H
I
V
R
R
Q
F
T
E
G
-----
S
G
V
P
D
L
A
C
V
Q
Q
D
A
T
G
N
A
W
D
I
V
L
S
Y
C
W
G
V
G
G
A
-------------------
R
-------------------------------------------------------------
S
G
I
---------------
I
-------
K
A
-
T
F
------------------------------------------
A
E
E
T
E
E
D
L
F
G
E
Q
A
V
L
C
G
G
L
V
E
L
V
K
A
G
F
E
T
L
T
E
A
G
Y
P
P
E
L
A
Y
F
E
C
Y
H
E
M
K
M
I
V
D
L
M
Y
E
S
G
I
H
F
M
N
Y
S
I
S
N
T
A
E
Y
G
E
Y
Y
A
G
P
K
V
I
N
E
Q
S
R
E
A
M
K
E
I
L
K
R
I
Q
D
G
S
F
A
Q
E
F
V
D
D
C
N
N
G
H
K
R
-
L
L
E
Q
R
E
A
I
N
T
H
P
I
E
T
T
G
A
Q
I
R
S
M
F
S
-
W
-
I
K
K
-------------
9
PsiBlast_PDB
70.83
53%
-34
- C4 -
4YPO
9
?
A:
[1-325]
---
M
F
Y
D
D
D
A
D
L
S
I
I
Q
G
R
K
V
G
V
I
G
Y
G
S
Q
G
H
A
H
S
L
S
L
R
D
S
------
G
V
Q
V
R
V
G
L
------
K
Q
-----
G
S
R
-
S
-
R
-
P
K
V
E
-----
E
Q
G
L
D
V
D
T
P
A
E
V
A
K
W
A
D
V
V
M
V
L
A
P
D
T
A
Q
A
E
I
F
-
A
G
D
I
E
P
N
L
K
P
G
D
A
L
F
F
G
H
G
L
N
V
H
F
G
L
---
I
K
P
P
A
D
V
A
V
A
M
V
A
P
K
G
P
G
H
L
V
R
R
Q
F
V
D
G
-----
K
G
V
P
C
L
V
A
V
E
Q
D
P
R
G
D
G
L
A
L
A
L
S
Y
A
K
A
I
G
G
T
-------------------
R
-------------------------------------------------------------
A
G
V
---------------
I
-------
K
T
-
T
F
------------------------------------------
K
D
E
T
E
T
D
L
F
G
E
Q
T
V
L
C
G
G
T
E
E
L
V
K
A
G
F
E
V
M
V
E
A
G
Y
P
A
E
L
A
Y
F
E
V
L
H
E
L
K
L
I
V
D
L
M
Y
E
G
G
L
A
R
M
Y
Y
S
V
S
D
T
A
E
F
G
G
Y
L
S
G
P
R
V
I
D
A
G
T
K
E
R
M
R
D
I
L
R
E
I
Q
D
G
S
F
V
H
K
L
V
A
D
V
E
G
G
N
K
Q
-
L
E
E
L
R
R
Q
N
A
E
H
P
I
E
V
V
G
K
K
L
R
D
L
M
S
-
W
-
V
---------------
24
PsiBlast_CBE
70.78
55%
-49
- C4 -
4KQW
8
?
B:
[13-337]
--
T
I
L
Y
E
Q
D
V
D
P
K
V
I
Q
G
L
K
V
G
I
I
G
Y
G
S
Q
G
H
A
H
A
L
N
L
M
D
S
------
G
V
D
V
R
V
G
L
------
R
E
-----
G
-
S
-
S
S
W
-
K
T
A
E
-----
E
A
G
L
K
V
T
D
M
D
T
A
A
E
E
A
D
V
I
M
V
L
V
P
D
E
I
Q
P
K
V
Y
-
Q
E
H
I
A
A
H
L
K
A
G
N
T
L
A
F
A
H
G
F
N
I
H
Y
G
Y
---
I
V
P
P
E
D
V
N
V
I
M
C
A
P
K
G
P
G
H
I
V
R
R
Q
F
T
E
G
-----
S
G
V
P
D
L
A
C
V
Q
Q
D
A
T
G
N
A
W
D
I
V
L
S
Y
C
W
G
V
G
G
A
-------------------
R
-------------------------------------------------------------
S
G
I
---------------
I
-------
K
A
-
T
F
------------------------------------------
A
E
E
T
E
E
D
L
F
G
E
Q
A
V
L
C
G
G
L
V
E
L
V
K
A
G
F
E
T
L
T
E
A
G
Y
P
P
E
L
A
Y
F
E
C
Y
H
E
M
K
M
I
V
D
L
M
Y
E
S
G
I
H
F
M
N
Y
S
I
S
N
T
A
E
Y
G
E
Y
Y
A
G
P
K
V
I
N
E
Q
S
R
E
A
M
K
E
I
L
K
R
I
Q
D
G
S
F
A
Q
E
F
V
D
D
C
N
N
G
H
K
R
-
L
L
E
Q
R
E
A
I
N
T
H
P
I
E
T
T
G
A
Q
I
R
S
M
F
S
-
W
-----------------
27
PsiBlast_CBE
70.75
53%
-37
- C4 -
4YPO
9
?
B:
[1-325]
---
M
F
Y
D
D
D
A
D
L
S
I
I
Q
G
R
K
V
G
V
I
G
Y
G
S
Q
G
H
A
H
S
L
S
L
R
D
S
------
G
V
Q
V
R
V
G
L
------
K
Q
-----
G
S
R
-
S
-
R
-
P
K
V
E
-----
E
Q
G
L
D
V
D
T
P
A
E
V
A
K
W
A
D
V
V
M
V
L
A
P
D
T
A
Q
A
E
I
F
-
A
G
D
I
E
P
N
L
K
P
G
D
A
L
F
F
G
H
G
L
N
V
H
F
G
L
---
I
K
P
P
A
D
V
A
V
A
M
V
A
P
K
G
P
G
H
L
V
R
R
Q
F
V
D
G
-----
K
G
V
P
C
L
V
A
V
E
Q
D
P
R
G
D
G
L
A
L
A
L
S
Y
A
K
A
I
G
G
T
-------------------
R
-------------------------------------------------------------
A
G
V
---------------
I
-------
K
T
-
T
F
------------------------------------------
K
D
E
T
E
T
D
L
F
G
E
Q
T
V
L
C
G
G
T
E
E
L
V
K
A
G
F
E
V
M
V
E
A
G
Y
P
A
E
L
A
Y
F
E
V
L
H
E
L
K
L
I
V
D
L
M
Y
E
G
G
L
A
R
M
Y
Y
S
V
S
D
T
A
E
F
G
G
Y
L
S
G
P
R
V
I
D
A
G
T
K
E
R
M
R
D
I
L
R
E
I
Q
D
G
S
F
V
H
K
L
V
A
D
V
E
G
G
N
K
Q
-
L
E
E
L
R
R
Q
N
A
E
H
P
I
E
V
V
G
K
K
L
R
D
L
M
S
-
W
-
V
---------------
5
PsiBlast_PDB
70.73
55%
-47
- C4 -
4KQX
10
?
A:
[14-335]
---
I
L
Y
E
Q
D
V
D
P
K
V
I
Q
G
L
K
V
G
I
I
G
Y
G
S
Q
G
H
A
H
A
L
N
L
M
D
S
------
G
V
D
V
R
V
G
L
------
R
E
-----
G
-
D
-
S
D
W
-
K
T
A
E
-----
E
A
G
L
K
V
T
D
M
D
T
A
A
E
E
A
D
V
I
M
V
L
V
P
D
E
V
Q
P
K
V
Y
-
Q
E
H
I
A
A
H
L
K
A
G
N
T
L
A
F
A
H
G
F
N
I
H
Y
G
Y
---
I
V
P
P
E
D
V
N
V
I
M
C
A
P
K
G
P
G
H
I
V
R
R
Q
F
T
E
G
-----
S
G
V
P
D
L
A
C
V
Q
Q
D
A
T
G
N
A
W
D
I
V
L
S
Y
C
W
G
V
G
G
A
-------------------
R
-------------------------------------------------------------
S
G
I
---------------
I
-------
K
A
-
T
F
------------------------------------------
A
E
E
T
E
E
D
L
F
G
E
Q
A
V
L
C
G
G
L
V
E
L
V
K
A
G
F
E
T
L
T
E
A
G
Y
P
P
E
L
A
Y
F
E
C
Y
H
E
M
K
M
I
V
D
L
M
Y
E
S
G
I
H
F
M
N
Y
S
I
S
N
T
A
E
Y
G
E
Y
Y
A
G
P
K
V
I
N
E
Q
S
R
E
A
M
K
E
I
L
K
R
I
Q
D
G
S
F
A
Q
E
F
V
D
D
C
N
N
G
H
K
R
-
L
L
E
Q
R
E
A
I
N
T
H
P
I
E
T
T
G
A
Q
I
R
S
M
F
--------------------
112
HHSearch
70.51
53%
-34
- C4 -
4YPO
9
?
A:
[1-325]
---
M
F
Y
D
D
D
A
D
L
S
I
I
Q
G
R
K
V
G
V
I
G
Y
G
S
Q
G
H
A
H
S
L
S
L
R
D
S
------
G
V
Q
V
R
V
G
L
------
K
Q
-----
G
-
S
-
R
-
S
R
P
K
V
E
-----
E
Q
G
L
D
V
D
T
P
A
E
V
A
K
W
A
D
V
V
M
V
L
A
P
D
T
A
Q
A
E
I
F
-
A
G
D
I
E
P
N
L
K
P
G
D
A
L
F
F
G
H
G
L
N
V
H
F
G
L
---
I
K
P
P
A
D
V
A
V
A
M
V
A
P
K
G
P
G
H
L
V
R
R
Q
F
V
D
G
-----
K
G
V
P
C
L
V
A
V
E
Q
D
P
R
G
D
G
L
A
L
A
L
S
Y
A
K
A
I
G
G
T
-------------------
R
-------------------------------------------------------------
A
G
V
---------------
I
-------
K
T
-
T
F
------------------------------------------
K
D
E
T
E
T
D
L
F
G
E
Q
T
V
L
C
G
G
T
E
E
L
V
K
A
G
F
E
V
M
V
E
A
G
Y
P
A
E
L
A
Y
F
E
V
L
H
E
L
K
L
I
V
D
L
M
Y
E
G
G
L
A
R
M
Y
Y
S
V
S
D
T
A
E
F
G
G
Y
L
S
G
P
R
V
I
D
A
G
T
K
E
R
M
R
D
I
L
R
E
I
Q
D
G
S
F
V
H
K
L
V
A
D
V
E
G
G
N
K
Q
-
L
E
E
L
R
R
Q
N
A
E
H
P
I
E
V
V
G
K
K
L
R
D
L
M
S
-
W
-
V
---------------
23
PsiBlast_CBE
69.96
56%
-47
- C4 -
4XIY
6
ILVC_AZOVD
B:
[1-328]
-
M
K
V
Y
Y
D
K
D
C
D
L
S
I
I
Q
S
K
K
V
A
I
I
G
Y
G
S
Q
G
H
A
H
A
C
N
L
K
D
S
------
G
V
D
V
Y
V
G
L
------
R
A
-----
G
-
S
A
S
-
V
-
A
K
A
E
-----
A
H
G
L
T
V
K
S
V
K
D
A
V
A
A
A
D
V
V
M
I
L
T
P
D
E
F
Q
G
R
L
Y
-
K
D
E
I
E
P
N
L
K
K
G
A
T
L
A
F
A
H
G
F
S
I
H
Y
N
Q
---
V
V
P
R
A
D
L
D
V
I
M
I
A
P
K
A
P
G
H
T
V
R
S
E
F
V
R
G
-----
G
G
I
P
D
L
I
A
V
Y
Q
D
A
S
G
N
A
K
N
L
A
L
S
Y
A
C
G
V
G
G
G
-------------------
R
-------------------------------------------------------------
T
G
I
---------------
I
-------
E
T
-
T
F
------------------------------------------
K
D
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
C
V
E
L
V
K
A
G
F
E
T
L
V
E
A
G
Y
A
P
E
M
A
Y
F
E
C
L
H
E
L
K
L
I
V
D
L
M
F
E
G
G
I
A
N
M
N
Y
S
I
S
N
N
A
E
Y
G
E
Y
V
T
G
P
E
V
I
N
E
Q
S
R
Q
A
M
R
N
A
L
K
R
I
Q
D
G
E
Y
A
K
M
F
I
T
E
G
A
A
N
Y
P
S
-
M
T
A
Y
R
R
N
N
A
A
H
Q
I
E
V
V
G
E
K
L
R
T
M
M
P
-
W
-
I
A
--------------
26
PsiBlast_CBE
69.53
55%
-49
- C4 -
4XDZ
10
?
B:
[2-325]
-
A
K
I
Y
K
D
E
D
I
S
L
E
P
I
K
N
K
T
I
A
I
L
G
Y
G
S
Q
G
R
A
W
A
L
N
L
R
D
S
------
G
L
N
V
V
V
G
L
E-----
R
Q
-----
G
-
D
-
S
-
W
-
R
R
A
I
-----
D
D
G
F
K
P
M
Y
T
K
D
A
V
A
I
A
D
I
I
V
F
L
V
P
D
M
V
Q
K
S
L
W
-
L
N
S
V
K
D
F
M
K
K
G
A
D
L
V
F
A
H
G
F
N
I
H
F
K
I
---
I
E
P
P
K
D
S
D
V
Y
M
I
A
P
K
S
P
G
P
I
V
R
R
S
Y
E
M
G
-----
G
G
V
P
A
L
V
A
V
Y
Q
N
V
S
G
E
A
L
Q
K
A
L
A
I
A
K
G
I
G
C
A
-------------------
R
-------------------------------------------------------------
A
G
V
---------------
I
-------
E
S
-
T
F
------------------------------------------
K
E
E
T
E
T
D
L
F
G
E
Q
V
I
L
V
G
G
I
M
E
L
I
K
A
S
F
E
T
L
V
E
E
G
Y
Q
P
E
V
A
Y
F
E
T
V
N
E
L
K
L
I
V
D
L
I
Y
E
K
G
L
T
G
M
L
R
A
V
S
D
T
A
K
Y
G
G
I
T
V
G
K
F
I
I
D
K
S
V
R
D
K
M
K
I
V
L
E
R
I
R
S
G
E
F
A
R
E
W
I
K
E
Y
E
R
G
M
P
T
V
F
K
E
L
S
E
L
E
G
-
S
T
I
E
T
V
G
R
K
L
R
E
M
M
--------------------
110
HHSearch
69.51
56%
-17
- C4 -
1NP3
-
ILVC_PSEAE
A:
[1-327]
-
M
R
V
F
Y
D
K
D
C
D
L
S
I
I
Q
G
K
K
V
A
I
I
G
Y
G
S
Q
G
H
A
H
A
C
N
L
K
D
S
------
G
V
D
V
T
V
G
L
------
R
S
-----
G
-
S
-
A
-
T
V
A
K
A
E
-----
A
H
G
L
K
V
A
D
V
K
T
A
V
A
A
A
D
V
V
M
I
L
T
P
D
E
F
Q
G
R
L
Y
K
E
-
E
I
E
P
N
L
K
K
G
A
T
L
A
F
A
H
G
F
S
I
H
Y
N
Q
---
V
V
P
R
A
D
L
D
V
I
M
I
A
P
K
A
P
G
H
T
V
R
S
E
F
V
K
G
-----
G
G
I
P
D
L
I
A
I
Y
Q
D
A
S
G
N
A
K
N
V
A
L
S
Y
A
C
G
V
G
G
G
-------------------
R
-------------------------------------------------------------
T
G
I
---------------
I
-------
E
T
-
T
F
------------------------------------------
K
D
E
T
E
T
D
L
F
G
E
Q
A
V
L
C
G
G
C
V
E
L
V
K
A
G
F
E
T
L
V
E
A
G
Y
A
P
E
M
A
Y
F
E
C
L
H
E
L
K
L
I
V
D
L
M
Y
E
G
G
I
A
N
M
N
Y
S
I
S
N
N
A
E
Y
G
E
Y
V
T
G
P
E
V
I
N
A
E
S
R
A
A
M
R
N
A
L
K
R
I
Q
D
G
E
Y
A
K
M
F
I
T
E
G
A
A
N
Y
P
S
-
M
T
A
Y
R
R
N
N
A
A
H
P
I
E
Q
I
G
E
K
L
R
A
M
M
P
-
W
-
I
---------------
7
PsiBlast_PDB
69.26
55%
-49
- C4 -
4XDZ
11
?
A:
[2-325]
-
A
K
I
Y
K
D
E
D
I
S
L
E
P
I
K
N
K
T
I
A
I
L
G
Y
G
S
Q
G
R
A
W
A
L
N
L
R
D
S
------
G
L
N
V
V
V
G
L
E-----
R
Q
-----
G
-
D
-
S
-
W
-
R
R
A
I
-----
D
D
G
F
K
P
M
Y
T
K
D
A
V
A
I
A
D
I
I
V
F
L
V
P
D
M
V
Q
K
S
L
W
-
L
N
S
V
K
D
F
M
K
K
G
A
D
L
V
F
A
H
G
F
N
I
H
F
K
I
---
I
E
P
P
K
D
S
D
V
Y
M
I
A
P
K
S
P
G
P
I
V
R
R
S
Y
E
M
G
-----
G
G
V
P
A
L
V
A
V
Y
Q
N
V
S
G
E
A
L
Q
K
A
L
A
I
A
K
G
I
G
C
A
-------------------
R
-------------------------------------------------------------
A
G
V
---------------
I
-------
E
S
-
T
F
------------------------------------------
K
E
E
T
E
T
D
L
F
G
E
Q
V
I
L
V
G
G
I
M
E
L
I
K
A
S
F
E
T
L
V
E
E
G
Y
Q
P
E
V
A
Y
F
E
T
V
N
E
L
K
L
I
V
D
L
I
Y
E
K
G
L
T
G
M
L
R
A
V
S
D
T
A
K
Y
G
G
I
T
V
G
K
F
I
I
D
K
S
V
R
D
K
M
K
I
V
L
E
R
I
R
S
G
E
F
A
R
E
W
I
K
E
Y
E
R
G
M
P
T
V
F
K
E
L
S
E
L
E
G
-
S
T
I
E
T
V
G
R
K
L
R
E
M
M
--------------------
113
HHSearch
69.14
54%
-50
- C4 -
4XDZ
11
?
A:
[2-329]
-
A
K
I
Y
K
D
E
D
I
S
L
E
P
I
K
N
K
T
I
A
I
L
G
Y
G
S
Q
G
R
A
W
A
L
N
L
R
D
S
------
G
L
N
V
V
V
G
L
------
E
R
-----
Q
-
G
-
D
-
S
W
R
R
A
I
-----
D
D
G
F
K
P
M
Y
T
K
D
A
V
A
I
A
D
I
I
V
F
L
V
P
D
M
V
Q
K
S
L
W
-
L
N
S
V
K
D
F
M
K
K
G
A
D
L
V
F
A
H
G
F
N
I
H
F
K
I
---
I
E
P
P
K
D
S
D
V
Y
M
I
A
P
K
S
P
G
P
I
V
R
R
S
Y
E
M
G
-----
G
G
V
P
A
L
V
A
V
Y
Q
N
V
S
G
E
A
L
Q
K
A
L
A
I
A
K
G
I
G
C
A
-------------------
R
-------------------------------------------------------------
A
G
V
---------------
I
-------
E
S
-
T
F
------------------------------------------
K
E
E
T
E
T
D
L
F
G
E
Q
V
I
L
V
G
G
I
M
E
L
I
K
A
S
F
E
T
L
V
E
E
G
Y
Q
P
E
V
A
Y
F
E
T
V
N
E
L
K
L
I
V
D
L
I
Y
E
K
G
L
T
G
M
L
R
A
V
S
D
T
A
K
Y
G
G
I
T
V
G
K
F
I
I
D
K
S
V
R
D
K
M
K
I
V
L
E
R
I
R
S
G
E
F
A
R
E
W
I
K
E
Y
E
R
G
M
P
T
-
V
F
K
E
L
S
E
L
E
G
S
T
I
E
T
V
G
R
K
L
R
E
M
M
F
R
G
-
M
---------------
107
HHSearch
61.65
51%
-53
- C4 -
5E4R
6
?
A:
[2-476]
-
A
K
I
Y
K
D
E
D
I
S
L
E
P
I
K
N
K
T
I
A
I
L
G
Y
G
S
Q
G
R
A
W
A
L
N
L
R
D
S
------
G
L
N
V
V
V
G
L
------
E
R
-----
Q
-
G
-
D
-
S
W
R
R
A
I
-----
D
D
G
F
K
P
M
Y
T
K
D
A
V
A
I
A
D
I
I
V
F
L
V
P
D
M
V
Q
K
S
L
W
-
L
N
S
V
K
D
F
M
K
K
G
A
D
L
V
F
A
H
G
F
N
I
H
F
K
I
---
I
E
P
P
K
D
S
D
V
Y
M
I
A
P
K
S
P
G
P
I
V
R
R
S
Y
E
M
G
-----
G
G
V
P
A
L
V
A
V
Y
Q
N
V
S
G
E
A
L
Q
K
A
L
A
I
A
K
G
I
G
C
A
RA
G
V
I
E
S
T
F
K
E
E
T
E
T
D
L
F
G
E
Q
VILV
G
G
I
M
E
L
I
K
A
S
F
E
T
L
V
E
E
GYQ
P
E
V
A
Y
F
E
T
V
N
E
L
K
L
I
V
D
L
I
Y
E
KG
L
T
G
M
L
R
A
V
S
D
T
A
K
Y
G
G
I
T
V
G
K
F
I
I
D
K
S
V
R
D
K
M
K
I
V
L
E
R
I
R
S
G
E
F
A
R
E
W
I
K
E
Y
E
R
GM
P
T
V
F
K
E
L
S
E
L
E
G
S
T
I
E
T
V
G
R
K
L
R
E
M
M
F
R
GM-------
L
F
G
E
Q
V
I
L
V
G
G
I
M
E
L
I
K
A
S
F
E
T
L
V
E
E
G
Y
Q
P
E
V
A
Y
F
E
T
V
N
E
L
K
L
I
V
D
L
I
Y
E
K
G
L
T
G
M
L
R
A
V
S
D
T
A
K
Y
G
G
I
T
V
G
K
F
I
I
D
K
S
V
R
D
K
M
K
I
V
L
E
R
I
R
S
G
E
F
A
R
E
W
I
K
E
Y
E
R
G
M
P
T
-
V
F
K
E
L
S
E
L
E
G
S
T
I
E
T
V
G
R
K
L
R
E
M
M
F
-
R
G
M
---------------
10
PsiBlast_PDB
59.29
47%
27
- C4 -
4XDY
9
?
A:
[1-328]
-
M
E
I
L
H
D
E
D
V
D
D
S
I
L
R
D
K
T
I
A
V
M
G
Y
G
A
Q
G
D
A
Q
A
N
C
L
K
D
S
------
G
I
N
V
V
I
G
E
T
EILGG
N
K
-----
N
-
P
-
S
-
W
-
E
K
A
K
-----
E
D
G
F
E
V
L
P
I
D
K
A
A
E
K
G
D
V
V
H
I
L
L
P
D
E
V
Q
P
A
I
Y
-
E
N
Q
I
K
P
Q
L
K
A
G
K
A
L
C
F
S
H
G
F
N
I
C
F
K
R
---
I
V
P
P
E
D
V
D
V
I
M
V
A
P
K
A
P
G
T
E
E
R
K
A
Y
L
E
G
-----
F
G
V
P
G
L
V
A
V
K
Q
N
P
S
G
E
A
R
E
V
A
L
A
M
T
K
A
M
H
W
T
-------------------
K
-------------------------------------------------------------
A
G
I
---------------
L
-------
E
C
-
T
F
------------------------------------------
E
Q
E
T
Y
E
D
L
F
G
E
Q
C
V
L
C
G
G
L
V
E
L
M
R
N
G
F
E
V
L
V
E
A
G
Y
P
P
E
M
A
Y
F
E
C
V
H
E
M
K
L
I
V
D
L
V
W
Q
G
G
I
K
R
M
A
E
V
I
S
N
T
A
E
Y
G
M
W
A
V
G
H
Q
I
I
G
P
E
V
K
E
K
M
K
E
A
L
K
R
V
E
N
G
E
F
A
N
E
W
V
D
E
Y
K
R
G
I
P
F
-
L
K
A
S
R
E
K
M
G
E
H
Q
V
E
T
V
G
A
E
I
R
K
L
---------------------
28
PsiBlast_CBE
59.24
47%
26
- C4 -
4XDY
9
?
B:
[1-328]
-
M
E
I
L
H
D
E
D
V
D
D
S
I
L
R
D
K
T
I
A
V
M
G
Y
G
A
Q
G
D
A
Q
A
N
C
L
K
D
S
------
G
I
N
V
V
I
G
E
TEILGG
N
K
-----
N
-
P
-
S
-
W
-
E
K
A
K
-----
E
D
G
F
E
V
L
P
I
D
K
A
A
E
K
G
D
V
V
H
I
L
L
P
D
E
V
Q
P
A
I
Y
-
E
N
Q
I
K
P
Q
L
K
A
G
K
A
L
C
F
S
H
G
F
N
I
C
F
K
R
---
I
V
P
P
E
D
V
D
V
I
M
V
A
P
K
A
P
G
T
E
E
R
K
A
Y
L
E
G
-----
F
G
V
P
G
L
V
A
V
K
Q
N
P
S
G
E
A
R
E
V
A
L
A
M
T
K
A
M
H
W
T
-------------------
K
-------------------------------------------------------------
A
G
I
---------------
L
-------
E
C
-
T
F
------------------------------------------
E
Q
E
T
Y
E
D
L
F
G
E
Q
C
V
L
C
G
G
L
V
E
L
M
R
N
G
F
E
V
L
V
E
A
G
Y
P
P
E
M
A
Y
F
E
C
V
H
E
M
K
L
I
V
D
L
V
W
Q
G
G
I
K
R
M
A
E
V
I
S
N
T
A
E
Y
G
M
W
A
V
G
H
Q
I
I
G
P
E
V
K
E
K
M
K
E
A
L
K
R
V
E
N
G
E
F
A
N
E
W
V
D
E
Y
K
R
G
I
P
F
-
L
K
A
S
R
E
K
M
G
E
H
Q
V
E
T
V
G
A
E
I
R
K
L
---------------------
108
HHSearch
58.97
47%
26
- C4 -
4XDY
9
?
A:
[1-331]
-
M
E
I
L
H
D
E
D
V
D
D
S
I
L
R
D
K
T
I
A
V
M
G
Y
G
A
Q
G
D
A
Q
A
N
C
L
K
D
S
------
G
I
N
V
V
I
G
E
------
T
E
ILGGN
K
-
N
-
P
-
S
W
E
K
A
K
-----
E
D
G
F
E
V
L
P
I
D
K
A
A
E
K
G
D
V
V
H
I
L
L
P
D
E
V
Q
P
A
I
Y
-
E
N
Q
I
K
P
Q
L
K
A
G
K
A
L
C
F
S
H
G
F
N
I
C
F
K
R
---
I
V
P
P
E
D
V
D
V
I
M
V
A
P
K
A
P
G
T
E
E
R
K
A
Y
L
E
G
-----
F
G
V
P
G
L
V
A
V
K
Q
N
P
S
G
E
A
R
E
V
A
L
A
M
T
K
A
M
H
W
T
-------------------
K
-------------------------------------------------------------
A
G
I
---------------
L
-------
E
C
-
T
F
------------------------------------------
E
Q
E
T
Y
E
D
L
F
G
E
Q
C
V
L
C
G
G
L
V
E
L
M
R
N
G
F
E
V
L
V
E
A
G
Y
P
P
E
M
A
Y
F
E
C
V
H
E
M
K
L
I
V
D
L
V
W
Q
G
G
I
K
R
M
A
E
V
I
S
N
T
A
E
Y
G
M
W
A
V
G
H
Q
I
I
G
P
E
V
K
E
K
M
K
E
A
L
K
R
V
E
N
G
E
F
A
N
E
W
V
D
E
Y
K
R
G
I
P
F
-
L
K
A
S
R
E
K
M
G
E
H
Q
V
E
T
V
G
A
E
I
R
K
L
F
A
-
Q
-----------------
14
PsiBlast_PDB
42.92
34%
22
- C4 -
3FR8
4
ILV5_ORYSJ
A:
[55-278]
-----------------
K
Q
I
G
V
I
G
W
G
S
Q
G
P
A
Q
A
Q
N
L
R
D
S
L
A
E
A
KS
D
I
V
V
K
I
G
L
------
R
K
-----
G
S
K
-
S
-
F
-
D
E
A
R
A
A
GFT
E
E
S
G
T
L
G
D
I
W
E
T
V
S
G
S
D
L
V
L
L
L
I
S
D
A
A
Q
A
D
N
Y
-
E
-
K
I
F
S
H
M
K
P
N
S
I
L
G
L
S
H
G
F
L
L
G
H
L
Q
S
A
G
L
D
F
P
K
N
I
S
V
I
A
V
C
P
K
G
M
G
P
S
V
R
R
L
Y
V
Q
G
K
E
ING
A
G
I
N
S
S
F
A
V
H
Q
D
V
D
G
R
A
T
D
V
A
L
G
W
S
V
A
L
G
S
P
-------------------
F
---------------------------------------------------------------
T
---------------
F
-------
A
T
-
T
L
------------------------------------------
E
Q
E
Y
K
S
D
I
F
G
E
R
G
I
L
L
G
A
V
H
G
I
V
E
A
L
F
R
R
Y
T
E
Q
G
M
D
E
E
M
A
Y
-------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
42.63
34%
24
- C4 -
3FR8
4
ILV5_ORYSJ
B:
[55-278]
-----------------
K
Q
I
G
V
I
G
W
G
S
Q
G
P
A
Q
A
Q
N
L
R
D
S
LAEAKS
D
I
V
V
K
I
G
L
------
R
K
-----
G
S
K
-
S
-
F
-
D
E
A
R
AAGFT
E
E
S
G
T
L
G
D
I
W
E
T
V
S
G
S
D
L
V
L
L
L
I
S
D
A
A
Q
A
D
N
Y
-
E
-
K
I
F
S
H
M
K
P
N
S
I
L
G
L
S
H
G
F
L
L
G
H
L
Q
S
A
G
L
D
F
P
K
N
I
S
V
I
A
V
C
P
K
G
M
G
P
S
V
R
R
L
Y
V
Q
G
K
EIN
G
A
G
I
N
S
S
F
A
V
H
Q
D
V
D
G
R
A
T
D
V
A
L
G
W
S
V
A
L
G
S
P
-------------------
F
---------------------------------------------------------------
T
---------------
F
-------
A
T
-
T
L
------------------------------------------
E
Q
E
Y
K
S
D
I
F
G
E
R
G
I
L
L
G
A
V
H
G
I
V
E
A
L
F
R
R
Y
T
E
Q
G
M
D
E
E
M
A
Y
-------------------------------------------------------------------------------------------------------------------------