@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu28310: (2016-07-14 )
MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAVLPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADAMIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFHIATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAKKPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYTANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGDSKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTKGEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVAVVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQPDFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGLHEMVGVKP
Atome Classification :
(22 SA)
.........10........20........30........40-.........50.-..-....-.60-........70.......-.--80--........90........100.......110......------.120-----........130.......140.......150.......160.......170.......180.......190..-..-.-..200....-------...210-.........220.......-230........240.......250.......260........270.-...-...280.......290.......300.-.....---------.---------.310.........320.......330..--.....340.------....--..350----........----.360.......-370.....-.--..380.......390-...---..-.-...400.......410.......420.......430.......440.......450.......460.......470.......480.......490..---------.....--------500-..---.-.....510.......520.......530.....----..----540.......550.......560.......570..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGT
N
V
Q
VDSAS
A
E
C
T
Q
T
M
S
G
A
L
M
L
I
E
S
L
K
K
E
K
V
E
M
I
FGYP--GGA
V
L
P
I
Y
D
K
L
Y-NS-G
L
V
H
-
I
LP-RHEQG
A
I
HAAE
G
Y
A
RVS-G--KP--
G
V
V
I
ATSGPG
A
T
N
L
V
T
G
L
A
D
A
M
I
DSL
P
L
V
V
FT
G
Q
V
A
T
------
S
V
I------G
S
D
AFQEA
D
I
L
G
I
TMPVTKHSYQVR
Q
P
E
D
L
P
R
I
I
K
E
A
F
H
I
ATTGRPG
P
V
L
I
DIPKD
V
A
TIE
G
E
F
SYDHEMNLP-GY-Q-PTTE
P
N
Y
L
Q
-------
I
R
K
L
---
V
E
A
V
SSAKK
P
V
I
L
AGAGVL-H-G
K
A
S
E
E
L
K
N
Y
A
E
Q
QQI
P
V
A
H
T
L
L
GLGGFPAD-H
P
L
F
L
G
MAGMH
G
-
T
Y
T-ANMA
L
H
EC
D
L
L
I
S
IGARFDDRVTG-
N
L
-
K
H
F
AR---------N---------
A
K
--
I
A
H
I
DI
D
P
A
E
I
G
K
I
M
K
TQIPVVGD--
S
K
I
V
L
Q
E
L
I
------
K
QDG--KQS------
D
S
S
E
W
K
K
Q
----
L
A
E
W
K
E
EYP
L
W
-
Y
-VDNEEE-G--F
K
P
Q
K
L
I
E
Y
I
H
Q
F---TKG---
E
A
-
I
-
V
A
TDVGQHQMWSAQFYPFQKAD
K
W
VTSGGLGTMGFG
L
P
A
A
I
G
A
Q
L
AEKD
A
T
V
V
A
V
VGDGGFQ
M
T
L
Q
E
L
D
V
I
R
ELNL
P
V
K
V
V
I
LN
N
A
C
L
G
M
V
R
Q
W
Q
E
I
F
---------
Y
E
E
RY--------SE--SK---F-ASQPD
F
V
K
L
S
E
AYGIK
G
I
R
IS
S
E
A
E
A
K
E
K
L
E
E
A
----LT----SRE
P
V
V
I
D
V
R
VASEE
K
V
F
P
M
VAPGK
G
L
H
E
M
VGVKP
23
PsiBlast_CBE
90.87
46%
-13
- C5 -
1T9D
9
ILVB_YEAST
C:
[82-659]
-----------------
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
--
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
-
D
K
F
N
F
V
L
P
-
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
--
K
P
--
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
------
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
---------------------------
N
K
A
---
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
--
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
--
A
T
T
N
L
G
K
M
M
------
S
K
I
F
--
P
V
K
------
E
R
S
E
W
F
A
Q
----
I
N
K
W
K
K
E
Y
P
Y
A
-
Y
-
M
E
-
E
T
P
-
G
SK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
Y
--------
S
H
--
T
----
H
-
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
----
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
N
F
D
P
24
PsiBlast_CBE
89.55
46%
-7
- C5 -
1T9D
9
ILVB_YEAST
B:
[82-659]
-----------------
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
--
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
-
D
K
F
N
F
V
L
P
-
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
--
K
P
--
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
------
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
---------------------F
V
M
Q
S
--
I
N
K
A
---
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
--
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
--
A
T
T
N
L
G
K
M
M
------
S
K
I
F
--
P
V
K
------
E
R
S
E
W
F
A
Q
----
I
N
K
W
K
K
E
Y
P
Y
A
-
Y
-
M
E
-
E
T
P
-
G
SK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
Y
--------
S
H
--
T
----
H
-
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
----
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
N
F
D
P
30
HHSearch
89.04
47%
2
- C5 -
5FEM
8
?
A:
[77-652]
------------
T
S
F
V
G
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
--
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
D
K
F
N
F
-
V
L
P
-
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
--
K
P
--
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
------
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
S--T
S
R
A
Q
D
E
F
V
M
Q
S
-------
I
N
K
A
---
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
-
N
H
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
---------
E
A
R
R
A
A
A
E
GR
G
G
--
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
--
A
T
T
N
L
G
K
M
M
------
S
K
I
F
--
P
V
K
------
E
R
S
E
W
F
A
Q
----
I
N
K
W
K
K
E
Y
P
Y
A
-
Y
M
E
E
T
P
G
S
-
K
--
I
K
P
Q
T
V
I
K
K
L
S
K
V
---
A
N
D
T
GR
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
Y
--------
S
H
--
T
H
---
Q
--
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
----
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
-------
3
PsiBlast_PDB
88.97
46%
-3
- C5 -
1T9B
9
ILVB_YEAST
A:
[82-659]
-----------------
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
--
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
-
D
K
F
N
F
V
L
P
-
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
--
K
P
--
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
------
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
---------------------F
V
M
Q
S
--
I
N
K
A
---
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
--
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
--
A
T
T
N
L
G
K
M
M
------
S
K
I
F
--
P
V
K
------
E
R
S
E
W
F
A
Q
----
I
N
K
W
K
K
E
Y
P
Y
A
-
Y
-
M
E
-
E
T
P
-
G
SK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
Y
--------
S
H
--
T
----
H
-
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
----
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
N
F
D
P
26
PsiBlast_CBE
88.87
46%
1
- C5 -
1T9B
9
ILVB_YEAST
B:
[82-659]
-----------------
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
--
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
-
D
K
F
N
F
V
L
P
-
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
--
K
P
--
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
------
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
-
S
----------
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
---
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
--
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
--
A
T
T
N
L
G
K
M
M
------
S
K
I
F
--
P
V
K
------
E
R
S
E
W
F
A
Q
----
I
N
K
W
K
K
E
Y
P
Y
A
-
Y
-
M
E
-
E
T
P
-
G
SK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
Y
--------
S
H
--
T
----
H
-
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
----
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
N
F
D
P
6
PsiBlast_PDB
88.74
46%
1
- C5 -
5FEM
8
?
A:
[82-659]
-----------------
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
--
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
-
D
K
F
N
F
V
L
P
-
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
--
K
P
--
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
------
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
-
S
--------
T
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
---
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
--
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
--
A
T
T
N
L
G
K
M
M
------
S
K
I
F
--
P
V
K
------
E
R
S
E
W
F
A
Q
----
I
N
K
W
K
K
E
Y
P
Y
A
-
Y
-
M
E
-
E
T
P
-
G
SK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
Y
--------
S
H
--
T
----
H
-
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
----
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
N
F
D
P
25
PsiBlast_CBE
88.71
46%
1
- C5 -
1T9C
7
ILVB_YEAST
B:
[82-659]
-----------------
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
--
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
-
D
K
F
N
F
V
L
P
-
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
--
K
P
--
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
------
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
--------------
Q
D
E
F
V
M
Q
S
I
N
K
A
---
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
--
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
--
A
T
T
N
L
G
K
M
M
------
S
K
I
F
--
P
V
K
------
E
R
S
E
W
F
A
Q
----
I
N
K
W
K
K
E
Y
P
Y
A
-
Y
-
M
E
-
E
T
P
-
G
SK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
Y
--------
S
H
--
T
----
H
-
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
----
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
N
F
D
P
2
PsiBlast_PDB
88.59
46%
1
- C5 -
1T9A
9
ILVB_YEAST
A:
[82-659]
-----------------
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
--
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
-
D
K
F
N
F
V
L
P
-
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
--
K
P
--
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
------
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
----------
T
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
---
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
--
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
--
A
T
T
N
L
G
K
M
M
------
S
K
I
F
--
P
V
K
------
E
R
S
E
W
F
A
Q
----
I
N
K
W
K
K
E
Y
P
Y
A
-
Y
-
M
E
-
E
T
P
-
G
SK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
Y
--------
S
H
--
T
----
H
-
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
----
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
N
F
D
P
27
PsiBlast_CBE
88.50
46%
1
- C5 -
1T9A
9
ILVB_YEAST
B:
[82-659]
-----------------
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
--
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
-
D
K
F
N
F
V
L
P
-
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
--
K
P
--
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
------
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
--------------
Q
D
E
F
V
M
Q
S
I
N
K
A
---
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
--
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
--
A
T
T
N
L
G
K
M
M
------
S
K
I
F
--
P
V
K
------
E
R
S
E
W
F
A
Q
----
I
N
K
W
K
K
E
Y
P
Y
A
-
Y
-
M
E
-
E
T
P
-
G
SK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
Y
--------
S
H
--
T
----
H
-
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
----
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
N
F
D
P
21
PsiBlast_CBE
88.47
46%
3
- C5 -
5FEM
8
?
B:
[82-659]
-----------------
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
--
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
-
D
K
F
N
F
V
L
P
-
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
--
K
P
--
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
------
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
-
S
--------
T
S
R
A
Q
DEFVMQS
I
N
K
A
---
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
EARRAAAEG
R
---------
G
G
--
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
--
A
T
T
N
L
G
K
M
M
------
S
K
I
F
--
P
V
K
------
E
R
S
E
W
F
A
Q
----
I
N
K
W
K
K
E
Y
P
Y
A
-
Y
-
M
E
-
E
T
P
-
G
SK
I
K
P
Q
T
V
I
K
K
L
S
K
V
AND
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
Y
--------
S
H
--
T
----
H
-
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
----
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
N
F
D
P
4
PsiBlast_PDB
88.38
46%
2
- C5 -
1T9C
7
ILVB_YEAST
A:
[82-659]
-----------------
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
--
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
-
D
K
F
N
F
V
L
P
-
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
--
K
P
--
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
------
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
-
S
---------
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
---
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
--
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
--
A
T
T
N
L
G
K
M
M
------
S
K
I
F
--
P
V
K
------
E
R
S
E
W
F
A
Q
----
I
N
K
W
K
K
E
Y
P
Y
A
-
Y
-
M
E
-
E
T
P
-
G
SK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
Y
--------
S
H
--
T
----
H
-
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
----
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
N
F
D
P
5
PsiBlast_PDB
88.14
46%
1
- C5 -
1T9D
9
ILVB_YEAST
A:
[82-659]
-----------------
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
--
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
-
D
K
F
N
F
V
L
P
-
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
--
K
P
--
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
------
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
----------
T
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
---
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
--
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
--
A
T
T
N
L
G
K
M
M
------
S
K
I
F
--
P
V
K
------
E
R
S
E
W
F
A
Q
----
I
N
K
W
K
K
E
Y
P
Y
A
-
Y
-
M
E
-
E
T
P
-
G
SK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
Y
--------
S
H
--
T
----
H
-
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
----
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
N
F
D
P
22
PsiBlast_CBE
87.95
46%
2
- C5 -
1T9D
10
ILVB_YEAST
D:
[82-659]
-----------------
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
--
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
-
D
K
F
N
F
V
L
P
-
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
--
K
P
--
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
------
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
-
S
---------
S
R
A
Q
DEFVMQS
I
N
K
A
---
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
EARRAAAEG
R
---------
G
G
--
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
--
A
T
T
N
L
G
K
M
M
------
S
K
I
F
--
P
V
K
------
E
R
S
E
W
F
A
Q
----
I
N
K
W
K
K
E
Y
P
Y
A
-
Y
-
M
E
-
E
T
P
-
G
SK
I
K
P
Q
T
V
I
K
K
L
S
K
V
AND
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
Y
--------
S
H
--
T
----
H
-
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
----
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
N
F
D
P
28
PsiBlast_CBE
87.94
46%
0
- C5 -
1N0H
9
ILVB_YEAST
B:
[82-659]
-----------------
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
--
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
-
D
K
F
N
F
V
L
P
-
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
--
K
P
--
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
------
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
-
S
---------
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
---
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
--
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
--
A
T
T
N
L
G
K
M
M
------
S
K
I
F
--
P
V
K
------
E
R
S
E
W
F
A
Q
----
I
N
K
W
K
K
E
Y
P
Y
A
-
Y
-
M
E
-
E
T
P
-
G
SK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
Y
--------
S
H
--
T
----
H
-
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
----
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
N
F
D
P
1
PsiBlast_PDB
87.27
46%
2
- C5 -
1N0H
9
ILVB_YEAST
A:
[82-659]
-----------------
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
--
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
-
D
K
F
N
F
V
L
P
-
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
--
K
P
--
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
------
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
-
S
--------
T
S
R
A
Q
D
E
F
V
M
Q
S
I
N
K
A
---
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
--
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
--
A
T
T
N
L
G
K
M
M
------
S
K
I
F
--
P
V
K
------
E
R
S
E
W
F
A
Q
----
I
N
K
W
K
K
E
Y
P
Y
A
-
Y
-
M
E
-
E
T
P
-
G
SK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
Q
G
M
V
T
Q
W
Q
S
L
F
---------
Y
E
H
R
Y
--------
S
H
--
T
----
H
-
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
----
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
V
P
V
L
P
M
V
A
G
G
S
G
L
D
E
F
I
N
F
D
P
32
HHSearch
84.76
35%
-21
* C5 *
2PAN
5
GCL_ECOLI
A:
[25-584]
---------------
A
K
M
R
A
V
D
A
A
M
Y
V
L
E
K
E
G
I
T
T
A
F
G
V
P
--
G
A
A
I
N
P
F
Y
S
A
M
R
-
K
H
G
G
I
R
H
-
I
L
A
-
R
H
V
E
G
A
S
H
M
A
E
G
Y
T
R
A
T
A
G
--
N
I
--
G
V
C
L
G
T
S
G
P
A
G
T
D
M
I
T
A
L
Y
S
A
S
A
D
S
I
P
I
L
C
I
T
G
Q
A
P
R
------
A
R
L
------
H
K
E
D
F
Q
A
V
D
I
E
A
I
A
K
P
V
S
K
M
A
V
T
V
R
E
A
A
L
V
P
R
V
L
Q
Q
A
F
H
L
M
R
S
G
R
P
G
P
V
L
V
D
L
P
F
D
V
Q
V
A
E
I
E
F
D
P
D
M
Y
E
P
L
P
-
V
Y
----
K
P
A
A
S
R
M
Q
-------
I
E
K
A
---
V
E
M
L
I
Q
A
E
R
P
V
I
V
A
G
G
G
V
I
-
N
-
A
D
A
A
A
L
L
Q
Q
F
A
E
L
T
S
V
P
V
I
P
T
L
M
G
W
G
C
I
P
D
D
-
H
E
L
M
A
G
M
V
G
L
Q
T
A
H
R
Y
-
G
N
A
T
L
L
A
S
D
M
V
F
G
I
G
N
R
F
A
N
R
H
T
G
-
S
V
-
E
K
Y
T
E
---------
G
---------
R
K
--
I
V
H
I
D
I
E
P
T
Q
I
G
R
V
L
C
P
D
L
G
I
V
S
D
--
A
K
A
A
L
T
L
L
V
------
E
V
A
Q
--
E
M
Q
K
A
GRLP
C
R
K
E
W
V
A
D
----
C
Q
Q
R
K
R
T
L
L
R
K
---
T
H
F
D
N
V
-
P
--
V
K
P
Q
R
V
Y
E
E
M
N
K
A
---
F
G
R
---
D
V
-
C
-
Y
V
T
T
I
G
L
S
Q
I
A
A
A
Q
M
L
H
V
F
K
D
R
H
W
I
N
C
G
Q
A
G
P
L
G
W
T
I
P
A
A
L
G
V
C
A
A
D
P
K
R
N
V
V
A
I
S
G
D
F
D
F
Q
F
L
I
E
E
L
A
V
G
A
Q
F
N
I
P
Y
I
H
V
L
V
N
N
A
Y
L
G
L
I
R
Q
S
Q
R
A
F
---------
D
M
D
Y
C
VQLAFENI
N
S
SE
V
N
---
G
--
Y
G
V
D
H
V
K
V
A
E
G
L
G
C
K
A
I
R
V
F
K
P
E
D
I
A
P
A
F
E
Q
A
----
K
A
L
M
A
Q
Y
R
V
P
V
V
V
E
V
I
L
E
R
V
T
N
I
------------------
7
PsiBlast_PDB
83.92
46%
5
- C5 -
1JSC
8
ILVB_YEAST
A:
[35-591]
-----------------
L
T
G
G
Q
I
F
N
E
M
M
S
R
Q
N
V
D
T
V
F
G
Y
P
--
G
G
A
I
L
P
V
Y
D
A
I
H
-
N
S
-
D
K
F
N
F
V
L
P
-
K
H
E
Q
G
A
G
H
M
A
E
G
Y
A
R
A
S
-
G
--
K
P
--
G
V
V
L
V
T
S
G
P
G
A
T
N
V
V
T
P
M
A
D
A
F
A
D
G
I
P
M
V
V
F
T
G
Q
V
P
T
------
S
A
I
------
G
T
D
A
F
Q
E
A
D
V
V
G
I
S
R
S
C
T
K
W
N
V
M
V
K
S
V
E
E
L
P
L
R
I
N
E
A
F
E
I
A
T
S
G
R
P
G
P
V
L
V
D
L
P
K
D
V
T
A
A
I
L
R
N
P
I
P
T
K
T
T
L
P
-
S
-----------
A
Q
D
E
F
V
M
Q
S
I
N
K
A
---
A
D
L
I
N
L
A
K
K
P
V
L
Y
V
G
A
G
I
L
N
H
-
A
D
G
P
R
L
L
K
E
L
S
D
R
A
Q
I
P
V
T
T
T
L
Q
G
L
G
S
F
D
Q
E
-
D
P
K
S
L
D
M
L
G
M
H
G
-
C
A
T
-
A
N
L
A
V
Q
N
A
D
L
I
I
A
V
G
A
R
F
D
D
R
V
T
G
-
N
I
-
S
K
F
A
P
E
A
R
R
A
A
A
E
G
R
---------
G
G
--
I
I
H
F
E
V
S
P
K
N
I
N
K
V
V
Q
T
Q
I
A
V
E
G
D
--
A
T
T
N
L
G
K
M
M
------
S
K
I
F
--
P
V
K
------
E
R
S
E
W
F
A
Q
----
I
N
K
W
K
K
E
Y
P
Y
A
-
Y
-
M
E
-
E
T
P
-
G
SK
I
K
P
Q
T
V
I
K
K
L
S
K
V
A
N
D
T
G
R
---
H
V
-
I
-
V
T
T
G
V
G
Q
H
Q
M
W
A
A
Q
H
W
T
W
R
N
P
H
T
F
I
T
S
G
G
L
G
T
M
G
Y
G
L
P
A
A
I
G
A
Q
V
A
K
P
E
S
L
V
I
D
I
D
G
D
A
S
F
N
M
T
L
T
E
L
S
S
A
V
Q
A
G
T
P
V
K
I
L
I
L
N
N
E
E
---------------------------------
S
H
--
T
H
-----
Q
L
N
P
D
F
I
K
L
A
E
A
M
G
L
K
G
L
R
V
K
K
Q
E
E
L
D
A
K
L
K
E
F
----
V
S
----
T
K
G
P
V
L
L
E
V
E
V
D
K
K
---------------------
8
PsiBlast_PDB
82.29
35%
-19
- C5 -
2PAN
5
GCL_ECOLI
A:
[37-576]
---------------------------
L
E
K
E
G
I
T
T
A
F
G
V
P
--
G
A
A
I
N
P
F
Y
S
A
M
R
K
H
G
-
G
I
R
H
-
I
L
A
-
R
H
V
E
G
A
S
H
M
A
E
G
Y
T
R
A
T
A
G
--
N
I
--
G
V
C
L
G
T
S
G
P
A
G
T
D
M
I
T
A
L
Y
S
A
S
A
D
S
I
P
I
L
C
I
T
G
Q
A
P
R
------
A
R
L
------
H
K
E
D
F
Q
A
V
D
I
E
A
I
A
K
P
V
S
K
M
A
V
T
V
R
E
A
A
L
V
P
R
V
L
Q
Q
A
F
H
L
M
R
S
G
R
P
G
P
V
L
V
D
L
P
F
D
V
Q
V
A
E
I
E
F
D
P
D
M
Y
E
P
L
P
-
V
Y
-
K
-
P
A
A
--
S
R
M
Q
-------
I
E
K
A
---
V
E
M
L
I
Q
A
E
R
P
V
I
V
A
G
G
G
V
I
-
N
-
A
D
A
A
A
L
L
Q
Q
F
A
E
L
T
S
V
P
V
I
P
T
L
M
G
W
G
C
I
P
D
D
-
H
E
L
M
A
G
M
V
G
L
Q
T
-
A
H
R
Y
G
N
A
T
L
L
A
S
D
M
V
F
G
I
G
N
R
F
A
N
R
H
T
G
-
S
V
-
E
K
Y
T
E
---------
G
---------
R
K
--
I
V
H
I
D
I
E
P
T
Q
I
G
R
V
L
C
P
D
L
G
I
V
S
D
--
A
K
A
A
L
T
L
L
V
E
V
A
Q
E
M
Q
K
A
G
--
R
L
P
------
C
R
K
E
W
V
A
D
----
C
Q
Q
R
K
R
T
L
-
L
R
-
K
-
T
H
F
D
N
V
-
P
--
V
K
P
Q
R
V
Y
E
E
M
N
K
A
---
F
G
R
---
D
V
-
C
-
Y
V
T
T
I
G
L
S
Q
I
A
A
A
Q
M
L
H
V
F
K
D
R
H
W
I
N
C
G
Q
A
G
P
L
G
W
T
I
P
A
A
L
G
V
C
A
A
D
P
K
R
N
V
V
A
I
S
G
D
F
D
F
Q
F
L
I
E
E
L
A
V
G
A
Q
F
N
I
P
Y
I
H
V
L
V
N
N
A
Y
L
G
L
I
R
Q
S
Q
R
A
F
DMDYCVQLA
F
E
N
I
N
--------
S
S
--
E
V
---
N
-
G
Y
G
V
D
H
V
K
V
A
E
G
L
G
C
K
A
I
R
V
F
K
P
E
D
I
A
P
A
F
E
Q
A
K
A
L
M
A
Q
----
Y
R
V
P
V
V
V
E
V
--------------------------
13
PsiBlast_PDB
78.40
26%
-41
- C5 -
4RJK
9
?
A:
[17-551]
-------------------
G
A
E
L
V
V
D
C
L
V
E
Q
G
V
T
H
V
F
G
I
P
--
G
A
K
I
D
A
V
F
D
A
L
Q
-
D
K
-
G
P
E
I
-
I
V
A
-
R
H
E
Q
N
A
A
F
M
A
Q
A
V
G
R
L
T
-
G
--
K
P
--
G
V
V
L
V
T
S
G
P
G
A
S
N
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
------
A
D
R
------
L
K
R
T
H
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
K
N
I
P
E
A
V
T
N
A
F
R
I
A
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
E
V
T
N
T
K
N
V
R
A
V
A
A
P
-
K
L
-
G
-
P
A
A
D
---
D
A
-------
I
S
A
A
---
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
K
G
G
-
R
-
P
E
A
I
K
A
V
R
K
L
L
K
K
V
Q
L
P
F
V
E
T
Y
Q
A
A
G
T
L
S
R
D
L
E
D
Q
Y
F
G
R
I
G
L
F
R
-
N
Q
P
-
G
D
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
---
D
P
I
E
Y
-
D
P
-
K
F
W
N
I
---------
N
---------
G
D
R
T
I
I
H
L
D
E
I
I
A
D
I
D
H
A
Y
Q
P
D
L
E
L
I
G
D
--
I
P
S
T
I
N
H
-
I
------
E
H
D
A
--
V
K
V
------
E
F
A
E
R
E
Q
K
I
L
S
D
L
K
Q
Y
M
H
E
G
E
Q
V
-
P
-
A
D
W
K
S
D
-
R
--
A
H
P
L
E
I
V
K
E
L
R
N
A
---
V
D
D
---
H
V
-
T
-
V
T
C
D
I
G
S
H
A
I
W
M
S
R
Y
F
R
S
Y
E
P
L
T
L
M
I
S
N
G
M
Q
T
L
G
V
A
L
P
W
A
I
G
A
S
L
V
K
P
G
E
K
V
V
S
V
S
G
D
G
G
F
L
F
S
A
M
E
L
E
T
A
V
R
L
K
A
P
I
V
H
I
V
W
N
D
S
T
Y
D
M
V
-
A
F
Q
Q
L
K
---------
K
Y
N
R
T
--------
S
A
--
V
D
---
F
-
G
N
I
-
D
I
V
K
Y
A
E
S
F
G
A
T
G
L
R
V
E
S
P
D
Q
L
A
D
V
L
R
Q
G
----
M
N
----
A
E
G
P
V
I
I
D
V
P
V
D
Y
S
D
N
I
------------------
14
PsiBlast_PDB
78.08
26%
-43
- C5 -
4RJI
3
?
A:
[17-551]
-------------------
G
A
E
L
V
V
D
C
L
V
E
Q
G
V
T
H
V
F
G
I
P
--
G
A
K
I
D
A
V
F
D
A
L
Q
-
D
K
-
G
P
E
I
-
I
V
A
-
R
H
E
Q
N
A
A
F
M
A
Q
A
V
G
R
L
T
-
G
--
K
P
--
G
V
V
L
V
T
S
G
P
G
A
S
N
L
A
T
G
L
L
T
A
N
T
E
G
D
P
V
V
A
L
A
G
N
V
I
R
------
A
D
R
------
L
K
R
T
H
Q
S
L
D
N
A
A
L
F
Q
P
I
T
K
Y
S
V
E
V
Q
D
V
K
N
I
P
E
A
V
T
N
A
F
R
I
A
S
A
G
Q
A
G
A
A
F
V
S
F
P
Q
D
V
V
N
E
V
T
N
T
K
N
V
R
A
V
A
A
P
-
K
L
-
G
-
P
A
A
D
---
D
A
-------
I
S
A
A
---
I
A
K
I
Q
T
A
K
L
P
V
V
L
V
G
M
K
G
G
-
R
-
P
E
A
I
K
A
V
R
K
L
L
K
K
V
Q
L
P
F
V
E
T
Y
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A
A
G
T
L
S
R
D
L
E
D
Q
Y
F
G
R
I
G
L
F
R
-
N
Q
P
-
G
D
L
L
L
E
Q
A
D
V
V
L
T
I
G
Y
---
D
P
I
E
Y
-
D
P
-
K
F
W
N
I
---------
N
---------
G
D
R
T
I
I
H
L
D
E
I
I
A
D
I
D
H
A
Y
Q
P
D
L
E
L
I
G
D
--
I
P
S
T
I
N
H
-
I
------
E
H
D
A
--
V
K
V
------
E
F
A
E
R
E
Q
K
I
L
S
D
L
K
Q
Y
M
H
E
G
E
---------
S
D
-
R
--
A
H
P
L
E
I
V
K
E
L
R
N
A
---
V
D
D
---
H
V
-
T
-
V
T
C
D
I
G
S
H
A
I
W
M
S
R
Y
F
R
S
Y
E
P
L
T
L
M
I
S
N
G
M
Q
T
L
G
V
A
L
P
W
A
I
G
A
S
L
V
K
P
G
E
K
V
V
S
V
S
G
D
G
G
F
L
F
S
A
M
E
L
E
T
A
V
R
L
K
A
P
I
V
H
I
V
W
N
D
S
T
Y
D
M
V
-
A
F
Q
Q
L
K
---------
K
Y
N
R
T
--------
S
A
--
V
D
---
F
-
G
N
I
-
D
I
V
K
Y
A
E
S
F
G
A
T
G
L
R
V
E
S
P
D
Q
L
A
D
V
L
R
Q
G
----
M
N
----
A
E
G
P
V
I
I
D
V
P
V
D
Y
S
D
N
I
------------------
38
HHSearch
75.11
32%
-6
- C5 -
5AHK
5
?
A:
[21-573]
-----------------
M
K
A
S
D
A
V
A
K
I
L
A
D
N
N
V
L
Y
G
F
E
L
I
--
G
G
M
I
T
H
L
V
D
S
I
N
-
L
L
G
K
T
K
L
-
V
S
M
-
H
H
E
Q
G
A
A
F
A
A
S
A
V
S
R
V
T
-
H
HK
T
L
--
G
L
A
L
A
T
S
G
P
G
A
T
N
L
I
T
G
I
A
D
C
W
L
D
S
H
P
C
I
F
L
T
G
Q
V
N
T
------
H
E
L
KGKRDI
R
Q
Q
G
F
Q
E
L
D
S
V
A
L
V
T
S
I
T
K
Y
A
Y
Q
I
K
S
A
D
E
L
V
P
C
L
R
K
A
I
Q
I
A
K
E
G
R
P
G
P
V
L
L
D
I
P
M
D
I
Q
R
A
D
I
D
E
A
L
L
N
N
------------
P
S
I
A
M
S
D
-------
L
D
F
I
---
I
N
K
L
Q
N
A
K
K
P
L
L
L
I
G
G
G
A
V
-
N
-
S
S
G
F
Q
K
W
L
E
Q
I
E
L
R
G
I
P
Y
V
A
S
L
K
G
A
E
K
I
K
A
--
S
D
L
Y
L
G
M
L
G
A
Y
G
-
T
R
A
-
A
N
H
A
V
Q
N
C
D
L
L
L
V
L
G
S
R
M
D
V
R
Q
T
G
-
A
Q
P
E
D
F
A
R
---------
N
---------
A
E
--
I
I
Q
I
D
L
Q
E
G
Q
L
N
N
R
V
I
A
D
F
S
Y
Q
I
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--
L
S
E
Y
F
S
R
F
S
------
P
L
Q
I
--
P
V
N
N-----
D
W
S
V
W
T
A
L
----
L
K
E
---
K
F
R
V
T
F
I
-
D
E
Y
T
T
W
-
N
--
L
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F
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L
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Q
L
N
K
L
---
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---
V
A
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-
Y
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L
D
V
G
N
N
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M
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A
A
H
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L
R
L
N
A
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Q
A
M
H
H
S
G
G
L
G
S
M
G
F
A
I
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A
A
I
G
A
C
Y
A
G
-
K
K
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I
I
V
I
T
G
D
G
G
A
Q
L
N
I
Q
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L
D
I
I
A
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D
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L
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I
L
T
I
V
M
N
N
H
S
L
G
M
V
R
G
F
Q
E
M
Y
---------
F
E
G
R
N
--------
S
S
--
T
Y
---
W
N
G
Y
T
S
Q
F
K
K
I
G
E
A
Y
R
V
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K
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I
S
M
Q
A
F
S
S
A
L
E
S
F
----
L
E
----
S
P
R
P
L
L
L
E
V
S
M
S
D
A
R
E
C
R
P
R
L
--------------
29
PsiBlast_CBE
71.53
32%
4
- C5 -
5AHK
5
?
B:
[35-581]
---------------------------------
N
V
L
Y
G
F
E
LI
G
G
M
I
T
H
L
V
D
S
I
N
-
L
L
-
G
K
T
K
-
L
V
S
M
H
H
E
Q
G
A
A
F
A
A
S
A
V
S
R
V
T
-
H
--
H
K
T
L
G
L
A
L
A
T
S
G
P
G
A
T
N
L
I
T
G
I
A
D
C
W
L
D
S
H
P
C
I
F
L
T
G
Q
V
N
T
HELKGK
R
D
I
------
R
Q
Q
G
F
Q
E
L
D
S
V
A
L
V
T
S
I
T
K
Y
A
Y
Q
I
K
S
A
D
E
L
V
P
C
L
R
K
A
I
Q
I
A
K
E
G
R
P
G
P
V
L
L
D
I
P
M
D
I
Q
R
A
D
I
D
E
A
L
L
N
------------------
I
A
-------
M
S
D
L
D
F
I
I
N
K
L
Q
N
A
K
K
P
L
L
L
I
G
G
G
A
V
-
N
-
S
S
G
F
Q
K
W
L
E
Q
I
E
L
R
G
I
P
Y
V
A
S
L
K
G
A
E
K
I
K
A
S
-
D
-
L
Y
L
G
M
L
G
A
Y
G
-
T
R
A
-
A
N
H
A
V
Q
N
C
D
L
L
L
V
L
G
S
R
M
D
V
R
Q
T
G
A
Q
P
-
E
D
F
A
R
---------
N
---------
A
E
--
I
I
Q
I
D
L
Q
E
G
Q
L
N
N
------
R
V
I
A
D
FS
Y
Q
I
E
L
S
E
Y
F
------
S
R
F
S
PL
Q
I
P
------
V
N
N
D
W
S
V
W
----
T
A
L
L
K
E
K
F
R
V
T
-
F
-
I
D
E
Y
T
T
W
N
--
L
S
P
F
G
L
F
T
Q
L
N
K
L
---
T
E
R
---
V
A
-
L
D
Y
I
L
D
V
G
N
N
Q
M
W
A
A
H
T
L
R
L
N
A
Q
Q
A
M
H
H
S
G
G
L
G
S
M
G
F
A
I
P
A
A
I
G
A
C
Y
A
G
K
K
P
I
I
V
-
I
T
G
D
G
G
A
Q
L
N
I
Q
E
L
D
I
I
A
R
D
K
L
P
I
L
T
I
V
M
N
N
H
S
L
G
M
V
R
G
F
--------------------------
S
S
--
T
Y
WNG
Y
-
T
S
Q
--
F
K
K
I
G
E
A
Y
R
V
E
S
K
T
I
I
S
M
Q
A
F
S
S
A
L
E
S
F
----
L
E
----
S
P
R
P
L
L
L
E
V
S
M
S
D
A
R
E
C
R
P
R
L
E
Y
G
R
A
I
D
Q
------