@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu28520: (2016-07-15 )
MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGENVQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKDLSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNIQASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEGFQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLAGMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS
Atome Classification :
(20 SA)
.........10.....-.-..20.....--...30--.-.-......40......-..-50....-....60........70........80........90........100.......110.......120...-.-...130.......140..-....--.150.......160.......170.------......-180.......190.-.......200.......210.......220.......230.......240.......250......-.260.......270.......280.......290.......300.......310.......320...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MG
K
K
V
I
V
L
G
EIRDGEL-
R
-
N
V
T
F
E
A
I
AA--GRTIS--G-D-G
E
V
I
G
V
LIGE
N
V
Q
S
-
I
A
-
Q
E
L
I
H
Y-GAD
K
V
LTAEDPK
L
K
T
Y
TAD
G
Y
S
Q
V
M
R
G
V
IEQENPD
S
V
I
FGHTAMGKDL
S
P
K
L
A
A
R
L
Q
TGLISD
A
I
D
V
S
V
T-G-G
N
V
V
F
T
RPIYS
G
K
A
F
E
R
V
-ISTD--
P
M
I
F
A
T
IRPNNIQASEKDTSRSGSI------
E
S
I
D
V
S
-
L
T
D
L
R
T
V
I
Q
E
V
V
-
K
-KTADGVDLSE
A
K
I
I
V
AGGRGVKSKE
G
F
Q
P
L
Q
E
L
A
E
V
L
G
A
A
VGASRGAC
D
A
D
Y
C
D
Y
A
L
QIGQTG
K
V
V-TP
D
L
Y
I
ACG
I
S
G
A
I
Q
H
L
AGMSN
S
K
V
I
V
A
INKDPEA
D
I
F
K
I
ADY
G
I
V
G
D
L
F
E
V
V
P
L
L
T
E
E
F
K
QLNIHS
6
PsiBlast_PDB
87.74
39%
-16
- C4 -
2A1U
1
ETFA_HUMAN
A:
[20-332]
--
Q
S
T
L
V
I
A
E
H
A
N
D
S
L
-
A
-
P
I
T
L
N
T
I
T
A
--
A
T
R
L
G
--
G
----
E
V
S
C
L
V
A
G
T
K
C
D
K
-
V
A
-
Q
D
L
C
K
V
A
G
I
A
K
V
L
V
A
Q
H
D
V
Y
K
G
L
L
P
E
E
L
T
P
L
I
L
A
T
Q
K
Q
F
N
Y
T
H
I
C
A
G
A
S
A
F
G
K
N
L
L
P
R
V
A
A
K
L
E
V
A
P
I
S
D
I
I
A
I
K
S
P
-
D
----
T
F
V
R
T
I
Y
A
G
N
A
L
C
T
V
-
K
C
D
E
--
K
V
K
V
F
S
V
R
G
T
S
F
D
A
A
A
T
S
G
G
S
A
S
S
E
------
K
A
S
S
T
S
-
P
V
E
I
S
E
W
L
D
Q
K
L
-
T
-
K
S
-
D
R
P
E
L
T
G
A
K
V
V
V
S
G
G
R
G
L
K
S
G
E
N
F
K
L
L
Y
D
L
A
D
Q
L
H
A
A
V
G
A
S
R
A
A
V
D
A
G
F
V
P
N
D
M
Q
V
G
Q
T
G
K
I
V
-
A
P
E
L
Y
I
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
T
I
V
A
I
N
K
D
P
E
A
P
I
F
Q
V
A
D
Y
G
I
V
A
D
L
F
K
V
V
P
E
M
T
E
I
L
K
K
-----
3
PsiBlast_PDB
87.64
39%
-17
- C4 -
1EFV
1
ETFA_HUMAN
A:
[2-313]
--
Q
S
T
L
V
I
A
E
H
A
N
D
S
L
-
A
-
P
I
T
L
N
T
I
T
A
--
A
T
R
L
G
--
G
----
E
V
S
C
L
V
A
G
T
K
C
D
K
-
V
A
-
Q
D
L
C
K
V
A
G
I
A
K
V
L
V
A
Q
H
D
V
Y
K
G
L
L
P
E
E
L
T
P
L
I
L
A
T
Q
K
Q
F
N
Y
T
H
I
C
A
G
A
S
A
F
G
K
N
L
L
P
R
V
A
A
K
L
E
V
A
P
I
S
D
I
I
A
I
K
S
P
-
D
----
T
F
V
R
T
I
Y
A
G
N
A
L
C
T
V
-
K
C
D
E
--
K
V
K
V
F
S
V
R
G
T
S
F
D
A
A
A
T
S
G
G
S
A
S
S
E
------
K
A
S
S
T
S
-
P
V
E
I
S
E
W
L
D
Q
K
L
-
T
-
K
S
-
D
R
P
E
L
T
G
A
K
V
V
V
S
G
G
R
G
L
K
S
G
E
N
F
K
L
L
Y
D
L
A
D
Q
L
H
A
A
V
G
A
S
R
A
A
V
D
A
G
F
V
P
N
D
M
Q
V
G
Q
T
G
K
I
V
-
A
P
E
L
Y
I
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
T
I
V
A
I
N
K
D
P
E
A
P
I
F
Q
V
A
D
Y
G
I
V
A
D
L
F
K
V
V
P
E
M
T
E
I
L
K
------
1
PsiBlast_PDB
87.45
38%
9
- C4 -
4KPU
3
?
A:
[13-337]
--
K
D
L
W
V
Y
V
E
H
Y
K
G
E
P
-
V
-
H
V
V
Y
E
L
L
G
E
--
C
R
K
L
A
D
K
C
-
N
-
Q
K
L
A
A
V
L
I
T
D
D
A
K
D
-
V
P
-
S
K
L
I
A
R
-
G
A
D
L
V
Y
V
C
Q
D
P
A
F
K
Y
Y
S
T
D
E
Y
T
N
A
F
C
E
M
I
D
E
Y
Q
P
S
S
V
F
I
G
A
T
N
D
G
R
D
L
G
P
R
I
A
A
R
V
N
T
G
L
C
A
D
C
T
I
L
D
A
E
E
D
-
G
L
I
E
W
T
R
P
A
A
G
G
N
I
M
A
T
I
-
L
C
K
E
HR
P
Q
M
-
G
T
V
R
P
K
T
F
K
A
M
E
P
D
A
S
R
T
G
E
V
I
N
Y
T
L
K
N
H
V
D
D
R
-
V
T
C
I
R
R
--
E
E
V
V
-
S
-
E
G
E
M
A
I
D
--
D
A
P
F
V
C
S
G
G
R
G
M
K
A
K
E
N
F
S
L
L
Y
D
L
A
H
A
L
G
G
A
V
G
G
S
R
A
A
V
D
E
G
F
I
E
H
P
R
Q
V
G
Q
S
G
K
T
V
-
T
P
K
I
Y
F
A
C
G
I
S
G
S
V
Q
H
K
A
G
M
S
K
S
D
T
I
V
C
I
N
K
D
P
D
A
P
M
F
E
I
S
K
Y
G
I
V
G
D
A
L
K
I
L
P
L
L
T
A
K
I
K
A
F
----
2
PsiBlast_PDB
87.08
38%
8
- C4 -
4L2I
3
?
A:
[13-337]
--
K
D
L
W
V
Y
V
E
H
Y
K
G
E
P
-
V
-
H
V
V
Y
E
L
L
G
E
--
C
R
K
L
A
D
K
C
-
N
-
Q
K
L
A
A
V
L
I
T
D
D
A
K
D
-
V
P
-
S
K
L
I
A
R
-
G
A
D
L
V
Y
V
C
Q
D
P
A
F
K
Y
Y
S
T
D
E
Y
T
N
A
F
C
E
M
I
D
E
Y
Q
P
S
S
V
F
I
G
A
T
N
D
G
R
D
L
G
P
R
I
A
A
R
V
N
T
G
L
C
A
D
C
T
I
L
D
A
E
E
D
-
G
L
I
E
W
T
R
P
A
A
G
G
N
I
M
A
T
I
-
L
C
K
E
HR
P
Q
M
-
G
T
V
R
P
K
T
F
K
A
M
E
P
D
A
S
R
T
G
E
V
I
N
Y
T
L
K
N
H
V
D
D
R
-
V
T
C
I
R
R
--
E
E
V
V
-
S
-
E
G
E
M
A
I
D
--
D
A
P
F
V
C
S
G
G
R
G
M
K
A
K
E
N
F
S
L
L
Y
D
L
A
H
A
L
G
G
A
V
G
G
S
R
A
A
V
D
E
G
F
I
E
H
P
R
Q
V
G
Q
S
G
K
T
V
-
T
P
K
I
Y
F
A
C
G
I
S
G
S
V
Q
H
K
A
G
M
S
K
S
D
T
I
V
C
I
N
K
D
P
D
A
P
M
F
E
I
S
K
Y
G
I
V
G
D
A
L
K
I
L
P
L
L
T
A
K
I
K
A
F
----
32
HHSearch
86.92
37%
-5
- C4 -
4L2I
3
?
A:
[12-338]
-
E
K
D
L
W
V
Y
V
E
H
Y
K
G
E
P
-
V
-
H
V
V
Y
E
L
L
G
E
--
C
R
K
L
A
--
D
K
C
N
Q
K
L
A
A
V
L
I
T
D
D
A
K
D
-
V
P
-
S
K
L
I
A
R
-
G
A
D
L
V
Y
V
C
Q
D
P
A
F
K
Y
Y
S
T
D
E
Y
T
N
A
F
C
E
M
I
D
E
Y
Q
P
S
S
V
F
I
G
A
T
N
D
G
R
D
L
G
P
R
I
A
A
R
V
N
T
G
L
C
A
D
C
T
I
L
D
A
E
-
E
D
G
L
I
E
W
T
R
P
A
A
G
G
N
I
M
A
T
I
-
L
C
K
E
H-
R
P
Q
M
G
T
V
R
P
K
T
F
K
A
M
E
P
D
A
S
R
T
G
E
V
------
I
N
Y
T
L
K
N
H
V
D
D
R
V
T
C
I
R
R
E
E
V
-
V
S
E
G
E
M
A
I
D
D
A
P
F
V
C
S
G
G
R
G
M
K
A
K
E
N
F
S
L
L
Y
D
L
A
H
A
L
G
G
A
V
G
G
S
R
A
A
V
D
E
G
F
I
E
H
P
R
Q
V
G
Q
S
G
K
T
V
-
T
P
K
I
Y
F
A
C
G
I
S
G
S
V
Q
H
K
A
G
M
S
K
S
D
T
I
V
C
I
N
K
D
P
D
A
P
M
F
E
I
S
K
Y
G
I
V
G
D
A
L
K
I
L
P
L
L
T
A
K
I
K
A
F
K
---
34
HHSearch
83.38
39%
-11
- C4 -
1EFV
1
ETFA_HUMAN
A:
[2-313]
--
Q
S
T
L
V
I
A
E
H
A
N
D
S
L
-
A
-
P
I
T
L
N
T
I
T
A
--
A
T
R
L
G
--
G
----
E
V
S
C
L
V
A
G
T
K
C
D
K
V
A
Q
-
D
L
C
K
V
A
-
G
I
A
K
V
L
V
A
Q
H
D
V
Y
K
G
L
L
P
E
E
L
T
P
L
I
L
A
T
Q
K
Q
F
N
Y
T
H
I
C
A
G
A
S
A
F
G
K
N
L
L
P
R
V
A
A
K
L
E
V
A
P
I
S
D
I
I
A
I
K
S
P
-
D
----
T
F
V
R
T
I
Y
A
G
N
A
L
C
T
V
-
K
C
D
E
--
K
V
K
V
F
S
V
R
G
T
S
F
D
A
A
A
T
S
G
G
S
-
A
S
S
------
E
K
A
S
S
T
-
S
P
V
E
I
S
E
W
L
D
Q
K
-
L
-
T
K
S
D
R
P
E
L
T
G
A
K
V
V
V
S
G
G
R
G
L
K
S
G
E
N
F
K
L
L
Y
D
L
A
D
Q
L
H
A
A
V
G
A
S
R
A
A
V
D
A
G
F
V
P
N
D
M
Q
V
G
Q
T
G
K
I
V
-
A
P
E
L
Y
I
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
T
I
V
A
I
N
K
D
P
E
A
P
I
F
Q
V
A
D
Y
G
I
V
A
D
L
F
K
V
V
P
E
M
T
E
I
L
K
------
5
PsiBlast_PDB
81.66
39%
-24
- C4 -
2A1T
1
ETFA_HUMAN
R:
[20-332]
--
Q
S
T
L
V
I
A
E
H
A
N
D
S
L
-
A
-
P
I
T
L
N
T
I
T
A
--
A
T
R
L
G
--
G
----
E
V
S
C
L
V
A
G
T
K
C
D
K
-
V
A
-
Q
D
L
C
K
V
A
G
I
A
K
V
L
V
A
Q
H
D
V
Y
K
G
L
L
P
E
E
L
T
P
L
I
L
A
T
Q
K
Q
F
N
Y
T
H
I
C
A
G
A
S
A
F
G
K
N
L
L
P
R
V
A
A
K
L
E
V
A
P
I
S
D
I
I
A
I
K
S
P
-
D
----
T
F
V
R
T
I
Y
A
G
N
A
L
C
T
V
-
K
C
D
E
--
K
V
K
V
F
S
V
R
G
T
S
F
D
A
A
A
T
S
G
G
S
A
S
S
E
------
K
A
S
S
T
S
-
P
V
E
I
S
E
W
L
D
Q
K
L
-
T
-----
R
P
E
L
T
G
A
K
V
V
V
S
G
G
R
G
L
K
S
G
E
N
F
K
L
L
Y
D
L
A
D
Q
L
H
A
A
V
G
A
S
R
A
A
V
D
A
G
F
V
P
N
D
M
Q
V
G
Q
T
G
K
I
V
-
A
P
E
L
Y
I
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
T
I
V
A
I
N
K
D
P
E
A
P
I
F
Q
V
A
D
Y
G
I
V
A
D
L
F
K
V
V
P
E
M
T
E
I
L
K
K
-----
22
Fugue
80.81
41%
13
- C4 -
1EFP
1
ETFA_PARDE
A:
[1-307]
---
A
V
L
L
L
G
E
V
T
N
G
A
L
N
R
-
D
A
T
A
K
A
V
A
A
--
V
K
A
L
---
G
----
D
V
T
V
L
C
A
G
A
S
A
K
A
-
A
A
-
E
E
A
A
K
I
A
G
V
A
K
V
L
V
A
E
D
A
L
Y
G
H
R
L
A
E
P
T
A
A
L
I
V
G
L
A
G
--
D
Y
S
H
I
A
A
P
A
T
T
D
A
K
N
V
M
P
R
V
A
A
L
L
D
V
M
V
L
S
D
V
S
A
I
L
D
A
-
D
----
T
F
E
R
P
I
Y
A
G
N
A
I
Q
V
V
-
K
S
K
D
--
A
K
K
V
F
T
I
R
T
A
S
F
D
A
A
G
E
G
G
T
A
P
V
T
E
------
T
A
-
A
A
A
-
D
P
G
L
S
S
W
V
A
D
E
--
V
-
A
E
S
D
R
P
E
L
T
S
A
R
R
V
V
S
G
G
R
G
L
G
S
K
E
S
F
A
I
I
E
E
L
A
D
K
L
G
A
A
V
G
A
S
R
A
A
V
D
S
G
Y
A
P
N
D
W
Q
V
G
Q
T
G
K
V
V
-
A
P
E
L
Y
V
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
V
I
V
A
I
N
K
D
E
E
A
P
I
F
Q
I
A
D
Y
G
L
V
G
D
L
F
S
V
V
P
E
L
T
G
K
L
-------
33
HHSearch
79.90
30%
-4
* C4 *
1O97
1
ETFA_METME
D:
[1-318]
--
S
K
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
--
A
N
G
L
K
--
K
S
G
E
D
K
V
V
V
A
V
I
G
S
Q
A
D
A
-
F
V
-
P
A
L
S
V
N
-
G
V
D
E
L
V
V
V
K
G
S
S
I
-
D
F
D
P
D
V
F
E
A
S
V
S
A
L
I
A
A
H
N
P
S
V
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
V
Y
I
V
E
Y
Q
-
G
-
D
E
L
V
A
T
R
G
G
Y
N
Q
K
V
N
V
E
V
-
D
F
P
G
K-
S
T
V
V
L
T
I
R
P
S
V
F
K
P
L
E
G
A
G
--
S
P
V
V
------
S
N
V
D
A
P
-
S
V
Q
S
R
S
Q
N
K
D
Y
V
E
V
-
G
---
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
L
A
D
E
A
G
A
T
L
C
C
S
R
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
E
E
E
L
K
A
Q
L
-------
15
PsiBlast_PDB
79.26
30%
3
- C4 -
3CLS
1
ETFA_METME
D:
[3-316]
---
K
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
AN
G
L
K
K
S
--
G
-
E
-
D
K
V
V
V
A
V
I
G
S
Q
A
D
A
-
F
V
-
P
A
L
S
V
N
-
G
V
D
E
L
V
V
V
K
G
S
S
I
D
-
F
D
P
D
V
F
E
A
S
V
S
A
L
I
A
A
H
N
P
S
V
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
V
Y
I
V
E
Y
Q
-
G
-
D
E
L
V
A
T
R
G
G
Y
N
Q
K
V
N
V
E
V
D
F
P
G
K
--
S
T
V
V
L
T
I
R
P
S
V
F
K
P
L
E
G
--
A
G
S
P
V
V
------
S
N
V
D
A
P
-
S
V
Q
S
R
S
Q
N
K
D
Y
V
-
E
V
G
G
G
N
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
L
A
D
E
A
G
A
T
L
C
C
S
C
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
----
E
E
E
L
K
------
11
PsiBlast_PDB
78.99
30%
-0
- C4 -
1O97
1
ETFA_METME
D:
[2-315]
---
K
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
AN
G
L
K
K
S
--
G
-
E
-
D
K
V
V
V
A
V
I
G
S
Q
A
D
A
-
F
V
-
P
A
L
S
V
N
-
G
V
D
E
L
V
V
V
K
G
S
S
I
D
-
F
D
P
D
V
F
E
A
S
V
S
A
L
I
A
A
H
N
P
S
V
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
V
Y
I
V
E
Y
Q
-
G
-
D
E
L
V
A
T
R
G
G
Y
N
Q
K
V
N
V
E
V
D
F
P
G
K
--
S
T
V
V
L
T
I
R
P
S
V
F
K
P
L
E
G
--
A
G
S
P
V
V
------
S
N
V
D
A
P
-
S
V
Q
S
R
S
Q
N
K
D
Y
V
-
E
V
G
---
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
L
A
D
E
A
G
A
T
L
C
C
S
R
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
----
E
E
E
L
K
------
13
PsiBlast_PDB
78.62
30%
4
- C4 -
3CLT
1
ETFA_METME
D:
[3-316]
---
K
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
AN
G
L
K
K
S
--
G
-
E
-
D
K
V
V
V
A
V
I
G
S
Q
A
D
A
-
F
V
-
P
A
L
S
V
N
-
G
V
D
E
L
V
V
V
K
G
S
S
I
D
-
F
D
P
D
V
F
E
A
S
V
S
A
L
I
A
A
H
N
P
S
V
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
V
Y
I
V
E
Y
Q
-
G
-
D
E
L
V
A
T
R
G
G
Y
N
Q
K
V
N
V
E
V
D
F
P
G
K
--
S
T
V
V
L
T
I
R
P
S
V
F
K
P
L
E
G
--
A
G
S
P
V
V
------
S
N
V
D
A
P
-
S
V
Q
S
R
S
Q
N
K
D
Y
V
-
E
V
G
G
G
N
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
L
A
D
E
A
G
A
T
L
C
C
S
E
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
----
E
E
E
L
K
------
21
PsiBlast_CBE
78.32
44%
-102
- C4 -
1EFP
1
ETFA_PARDE
C:
[55-304]
---------------------------------------------------------------------
K
V
L
V
A
E
D
A
L
Y
G
H
R
L
A
E
P
T
A
A
L
I
V
G
L
A
G
D
Y
S
--
H
I
A
A
P
A
T
T
D
A
K
N
V
M
P
R
V
A
A
L
L
D
V
M
V
L
S
D
---
V
S
A
I
-
L
-
D
A
D
T
F
E
R
P
I
Y
A
G
N
A
I
Q
V
V
-
K
S
K
D
--
A
K
K
V
F
T
I
R
T
A
S
F
D
A
A
-
G
E
G
G
T
A
P
V
T
------
E
T
A
A
A
A
-
D
P
G
L
S
S
W
V
A
D
E
V
-
A
-
E
S
-
D
R
P
E
L
T
S
A
R
R
V
V
S
G
G
R
G
L
G
S
K
E
S
F
A
I
I
E
E
L
A
D
K
L
G
A
A
V
G
A
S
R
A
A
V
D
S
G
Y
A
P
N
D
W
Q
V
G
Q
T
G
K
V
V
-
A
P
E
L
Y
V
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
V
I
V
A
I
N
K
D
E
E
A
P
I
F
Q
I
A
D
Y
G
L
V
G
D
L
F
S
V
V
P
E
L
T
----------
35
HHSearch
78.28
41%
12
- C4 -
1EFP
1
ETFA_PARDE
A:
[1-307]
---
A
V
L
L
L
G
E
V
T
N
G
A
L
-
N
R
D
A
T
A
K
A
V
A
A
--
V
K
A
L
G
--
D
-----
V
T
V
L
C
A
G
A
S
A
K
A
-
A
A
E
E
A
A
K
I
A
-
G
V
A
K
V
L
V
A
E
D
A
L
Y
G
H
R
L
A
E
P
T
A
A
L
I
V
G
L
A
G
--
D
Y
S
H
I
A
A
P
A
T
T
D
A
K
N
V
M
P
R
V
A
A
L
L
D
V
M
V
L
S
D
V
S
A
I
L
D
A
-
D
----
T
F
E
R
P
I
Y
A
G
N
A
I
Q
V
V
-
K
S
K
D
--
A
K
K
V
F
T
I
R
T
A
S
F
D
A
A
G
E
G
G
--
T
A
P
V
------
T
E
T
A
A
A
-
A
D
P
G
L
S
S
W
V
A
D
E
-
V
-
A
E
S
D
R
P
E
L
T
S
A
R
R
V
V
S
G
G
R
G
L
G
S
K
E
S
F
A
I
I
E
E
L
A
D
K
L
G
A
A
V
G
A
S
R
A
A
V
D
S
G
Y
A
P
N
D
W
Q
V
G
Q
T
G
K
V
V
-
A
P
E
L
Y
V
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
V
I
V
A
I
N
K
D
E
E
A
P
I
F
Q
I
A
D
Y
G
L
V
G
D
L
F
S
V
V
P
E
L
T
G
K
L
-------
12
PsiBlast_PDB
77.87
30%
7
- C4 -
3CLU
1
ETFA_METME
D:
[3-316]
---
K
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
AN
G
L
K
K
S
--
G
-
E
-
D
K
V
V
V
A
V
I
G
S
Q
A
D
A
-
F
V
-
P
A
L
S
V
N
-
G
V
D
E
L
V
V
V
K
G
S
S
I
D
-
F
D
P
D
V
F
E
A
S
V
S
A
L
I
A
A
H
N
P
S
V
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
V
Y
I
V
E
Y
Q
-
G
-
D
E
L
V
A
T
R
G
G
Y
N
Q
K
V
N
V
E
V
D
F
P
G
K
--
S
T
V
V
L
T
I
R
P
S
V
F
K
P
L
E
G
--
A
G
S
P
V
V
------
S
N
V
D
A
P
-
S
V
Q
S
R
S
Q
N
K
D
Y
V
-
E
V
G
G
G
N
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
L
A
D
E
A
G
A
T
L
C
C
S
K
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
----
E
E
E
L
K
------
7
PsiBlast_PDB
77.83
44%
-104
- C4 -
1EFP
1
ETFA_PARDE
A:
[55-304]
---------------------------------------------------------------------
K
V
L
V
A
E
D
A
L
Y
G
H
R
L
A
E
P
T
A
A
L
I
V
G
L
A
G
D
Y
S
--
H
I
A
A
P
A
T
T
D
A
K
N
V
M
P
R
V
A
A
L
L
D
V
M
V
L
S
D
---
V
S
A
I
-
L
-
D
A
D
T
F
E
R
P
I
Y
A
G
N
A
I
Q
V
V
-
K
S
K
D
--
A
K
K
V
F
T
I
R
T
A
S
F
D
A
A
-
G
E
G
G
T
A
P
V
T
------
E
T
A
A
A
A
-
D
P
G
L
S
S
W
V
A
D
E
V
-
A
-
E
S
-
D
R
P
E
L
T
S
A
R
R
V
V
S
G
G
R
G
L
G
S
K
E
S
F
A
I
I
E
E
L
A
D
K
L
G
A
A
V
G
A
S
R
A
A
V
D
S
G
Y
A
P
N
D
W
Q
V
G
Q
T
G
K
V
V
-
A
P
E
L
Y
V
A
V
G
I
S
G
A
I
Q
H
L
A
G
M
K
D
S
K
V
I
V
A
I
N
K
D
E
E
A
P
I
F
Q
I
A
D
Y
G
L
V
G
D
L
F
S
V
V
P
E
L
T
----------
14
PsiBlast_PDB
77.73
30%
4
- C4 -
3CLR
2
ETFA_METME
D:
[3-316]
---
K
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
AN
G
L
K
K
S
--
G
-
E
-
D
K
V
V
V
A
V
I
G
S
Q
A
D
A
-
F
V
-
P
A
L
S
V
N
-
G
V
D
E
L
V
V
V
K
G
S
S
I
D
-
F
D
P
D
V
F
E
A
S
V
S
A
L
I
A
A
H
N
P
S
V
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
V
Y
I
V
E
Y
Q
-
G
-
D
E
L
V
A
T
R
G
G
Y
N
Q
K
V
N
V
E
V
D
F
P
G
K
--
S
T
V
V
L
T
I
R
P
S
V
F
K
P
L
E
G
--
A
G
S
P
V
V
------
S
N
V
D
A
P
-
S
V
Q
S
R
S
Q
N
K
D
Y
V
-
E
V
G
G
G
N
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
L
A
D
E
A
G
A
T
L
C
C
S
A
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
----
E
E
E
L
K
------
10
PsiBlast_PDB
77.61
30%
1
- C4 -
1O96
1
ETFA_METME
B:
[2-315]
---
K
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
A
N
G
L
K
K
S
--
G
-
E
-
D
K
V
V
V
A
V
I
G
S
Q
A
D
A
-
F
V
-
P
A
L
S
V
N
-
G
V
D
E
L
V
V
V
K
G
S
S
I
D
-
F
D
P
D
V
F
E
A
S
V
S
A
L
I
A
A
H
N
P
S
V
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
V
Y
I
V
E
Y
Q
-
G
-
D
E
L
V
A
T
R
G
G
Y
N
Q
K
V
N
V
E
V
D
F
P
G
K
--
S
T
V
V
L
T
I
R
P
S
V
F
K
P
L
E
G
--
A
G
S
P
V
V
------
S
N
V
D
A
P
-
S
V
Q
S
R
S
Q
N
K
D
Y
V
-
E
V----
D
I
D
I
T
T
V
D
F
I
M
S
I
G
R
G
I
G
E
E
T
N
V
E
Q
F
R
E
L
A
D
E
A
G
A
T
L
C
C
S
R
P
I
A
D
A
G
W
L
P
K
S
R
Q
V
G
Q
S
G
K
V
V
G
S
C
K
L
Y
V
A
M
G
I
S
G
S
I
Q
H
M
A
G
M
K
H
V
P
T
I
I
A
V
N
T
D
P
G
A
S
I
F
T
I
A
K
Y
G
I
V
A
D
I
F
D
I
----
E
E
E
L
K
------
4
PsiBlast_PDB
61.51
39%
-44
- C4 -
1T9G
-
ETFA_HUMAN
R:
[20-203]
--
Q
S
T
L
V
I
A
E
H
A
N
D
S
L
-
A
-
P
I
T
L
N
T
I
T
A
--
A
T
R
L
G
--
G
----
E
V
S
C
L
V
A
G
T
K
C
D
K
-
V
A
-
Q
D
L
C
K
V
A
G
I
A
K
V
L
V
A
Q
H
D
V
Y
K
G
L
L
P
E
E
L
T
P
L
I
L
A
T
Q
K
Q
F
N
Y
T
H
I
C
A
G
A
S
A
F
G
K
N
L
L
P
R
V
A
A
K
L
E
V
A
P
I
S
D
I
I
A
I
K
S
P
-
D
----
T
F
V
R
T
I
Y
A
G
N
A
L
C
T
V
-
K
C
D
E
--
K
V
K
V
F
S
V
R
G
T
S
F
D
A
A
A
T
S
G
G
S
A
S
S
E
------
K
A
S
S
T
S
-
P
V
E
I
S
E
W
L
D
Q
K
------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
57.16
30%
-20
- C4 -
1O95
-
ETFA_METME
D:
[2-189]
---
K
I
L
V
I
A
E
H
R
R
N
D
L
-
R
-
P
V
S
L
E
L
I
G
A
AN
G
L
K
K
S
--
G
-
E
-
D
K
V
V
V
A
V
I
G
S
Q
A
D
A
-
F
V
-
P
A
L
S
V
N
-
G
V
D
E
L
V
V
V
K
G
S
S
I
D
-
F
D
P
D
V
F
E
A
S
V
S
A
L
I
A
A
H
N
P
S
V
V
L
L
P
H
S
V
D
S
L
G
Y
A
S
S
L
A
S
K
T
G
Y
G
F
A
T
D
V
Y
I
V
E
Y
Q
-
G
-
D
E
L
V
A
T
R
G
G
Y
N
Q
K
V
N
V
E
V
D
F
P
G
K
--
S
T
V
V
L
T
I
R
P
S
V
F
K
P
L
E
G
--
A
G
S
P
V
V
------
S
N
V
D
A
P
-
S
V
Q
S
R
S
Q
N
K
D
Y
V
-----------------------------------------------------------------------------------------------------------------------------------------