@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu28820: (2016-07-16 )
MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTTDRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQRVTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDMIVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGLRGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLRDAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRDDYENAVKLITEVIKKLDRKTVDEITYQ
Atome Classification :
(20 SA)
.........10........20........30........40........50.-.......60........70........80........90........100.......110........120.......130.......140.......150.......160.......170.......180.......190.....--..-200........210.......220.......230.......240.......250.......260.......270.......280.......290....-.-..300..--.....310.......320.......330.......340.......350.......360
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
K
L
D
E
T
L
T
M
L
K
D
L
T
DAKGIPG
N
E
R
E
V
R
Q
V
M
K
S
Y
I
E
P
F
A
D
E
V
T
T
D
R
L
G
S
L
I
A
-
K
KTGAENG
P
K
I
M
I
A
GH
L
D
E
V
G
F
M
V
T
QITDK
G
F
I
R
F
QTV
G
G
W
W
A
Q
V
M
L
A
Q
R
V
T
I
V
TKKG-
E
I
T
G
VIGSKPPHILS
P
E
A
RKK
S
V
E
I
K
D
M
F
I
DIGAS
S
R
E
E
A
L
E
WGVLPGD
M
I
V
P
H
F
E
F
T
V
MNN
E
K
F
L
L
A
K
AWDNRIG
C
A
I
A
I
D
V
L
R
N
L
--QN-T-DHP
N
I
V
Y
GVG
T
V
Q
E
E
VGLRGAKTAAHTIQPD
I
A
F
G
V
D
VGIAGDTPGI
S
E
K
E
A
Q
S
KMGKG
P
Q
I
I
V
Y
D
A
S
M
VSHKG
L
R
D
A
V
V
A
T
A
E
EAGI
P
Y
Q
F
DAIA-G-GGTDS
G
A
--
I
H
L
TANGV
P
A
L
S
I
T
I
A
T
R
Y
I
H
T
H
A
A
M
L
HR
D
D
Y
E
N
A
V
K
L
I
T
E
V
I
K
K
L
D
R
K
T
V
D
E
ITYQ
80
HHSearch
97.42
100%
-92
- C3 -
1VHE
1
YSDC_BACSU
A:
[5-363]
--
K
L
D
E
T
L
T
M
L
K
D
L
T
D
A
K
G
I
P
G
N
E
R
E
V
R
Q
V
M
K
S
Y
I
E
P
F
A
D
E
V
T
T
D
R
L
G
S
L
I
A
-
K
K
T
G
A
E
N
G
P
K
I
M
I
A
G
H
L
D
E
V
G
F
M
V
T
Q
I
T
D
K
G
F
I
R
F
Q
T
V
G
G
W
W
A
Q
V
M
L
A
Q
R
V
T
I
V
T
K
K
G
-
E
I
T
G
V
I
G
S
K
P
P
H
I
L
S
P
E
A
R
K
K
S
V
E
I
K
D
M
F
I
D
I
G
A
S
S
R
E
E
A
L
E
W
G
V
L
P
G
D
M
I
V
P
H
F
E
F
T
V
M
N
N
E
K
F
L
L
A
K
A
W
D
N
R
I
G
C
A
I
A
I
D
V
L
R
N
L
--
Q
N
-
T
-
D
H
P
N
I
V
Y
G
V
G
T
V
Q
E
E
V
G
L
R
G
A
K
T
A
A
H
T
I
Q
P
D
I
A
F
G
V
D
V
G
I
A
G
D
T
P
G
I
S
E
K
E
A
Q
S
K
M
G
K
G
P
Q
I
I
V
Y
D
A
S
M
V
S
H
K
G
L
R
D
A
V
V
A
T
A
E
E
A
G
I
P
Y
Q
F
D
A
I
A
-
G
-
G
G
T
D
S
G
A
--
I
H
L
T
A
N
G
V
P
A
L
S
I
T
I
A
T
R
Y
I
H
T
H
A
A
M
L
H
R
D
D
Y
E
N
A
V
K
L
I
T
E
V
I
K
K
L
D
R
K
T
V
D
E
I
T
Y
Q
1
PsiBlast_PDB
96.59
96%
-92
- C3 -
1VHE
1
YSDC_BACSU
A:
[5-363]
--
K
L
D
E
T
L
T
M
L
K
D
L
T
D
A
K
G
I
P
G
N
E
R
E
V
R
Q
V
M
K
S
Y
I
E
P
F
A
D
E
V
T
T
D
R
L
G
S
L
I
A
-
K
K
T
G
A
E
N
G
P
K
I
M
I
A
G
H
L
D
E
V
G
F
M
V
T
Q
I
T
D
K
G
F
I
R
F
Q
T
V
G
G
W
W
A
Q
V
M
L
A
Q
R
V
T
I
V
T
K
K
G
-
E
I
T
G
V
I
G
S
K
P
P
H
I
L
S
P
E
A
R
K
K
S
V
E
I
K
D
M
F
I
D
I
G
A
S
S
R
E
E
A
L
E
W
G
V
L
P
G
D
M
I
V
P
H
F
E
F
T
V
M
N
N
E
K
F
L
L
A
K
A
W
D
N
R
I
G
C
A
I
A
I
D
V
L
R
N
L
--
Q
N
-
T
-
D
H
P
N
I
V
Y
G
V
G
T
V
Q
E
E
V
G
L
R
G
A
K
T
A
A
H
T
I
Q
P
D
I
A
F
G
V
D
V
G
I
A
G
D
T
P
G
I
S
E
K
E
A
Q
S
K
M
G
K
G
P
Q
I
I
V
Y
D
A
S
M
V
S
H
K
G
L
R
D
A
V
V
A
T
A
E
E
A
G
I
P
Y
Q
F
D
A
I
A
-
G
-
G
G
T
D
S
G
A
--
I
H
L
T
A
N
G
V
P
A
L
S
I
T
I
A
T
R
Y
I
H
T
H
A
A
M
L
H
R
D
D
Y
E
N
A
V
K
L
I
T
E
V
I
K
K
L
D
R
K
T
V
D
E
I
T
Y
Q
82
HHSearch
80.32
50%
-63
- C3 -
5DS0
3
?
A:
[2-359]
--
N
A
D
K
S
M
E
L
M
K
T
L
M
E
A
F
G
P
S
G
F
E
R
E
V
N
A
I
C
K
E
Y
M
E
P
Y
A
D
E
V
V
V
D
K
L
G
S
V
T
F
-
I
A
K
G
N
-
D
R
P
R
I
L
M
A
G
H
T
D
E
V
G
F
I
V
S
S
I
S
K
E
G
Y
L
T
F
N
T
L
G
G
W
W
S
Q
V
L
L
G
Q
R
V
V
V
R
T
C
K
G
-
M
V
H
G
I
I
A
S
K
P
P
H
I
L
P
P
D
E
R
K
K
I
V
E
A
R
D
M
F
I
D
I
G
A
T
S
E
E
E
A
E
E
S
G
V
K
V
G
D
P
I
V
P
W
S
P
F
S
V
I
Q
N
G
R
V
A
M
G
K
A
F
D
D
R
I
G
A
F
V
L
M
E
A
I
R
R
M
--
K
D
Q
G
I
E
H
P
N
T
V
Y
G
S
A
T
V
Q
E
E
V
G
L
R
G
A
Q
T
T
A
H
V
V
D
P
D
V
A
L
V
L
E
V
D
I
A
G
D
V
P
--
K
P
H
E
A
L
T
K
M
G
K
G
P
G
L
V
T
Y
D
R
S
M
I
P
N
Q
P
L
K
E
F
V
I
N
V
A
K
Q
A
Q
I
P
L
Q
L
S
Q
M
S
-
G
-
G
G
T
D
A
G
R
I
H
M
N
--
R
A
G
C
P
S
V
V
I
T
I
P
T
R
H
I
H
S
H
V
G
L
L
S
L
K
D
T
E
N
A
I
R
L
V
I
E
L
I
K
R
L
D
L
E
T
V
E
G
F
T
--
2
PsiBlast_PDB
78.63
49%
-50
- C3 -
5DS0
3
?
A:
[4-359]
----
D
K
S
M
E
L
M
K
T
L
M
E
A
F
G
P
S
G
F
E
R
E
V
N
A
I
C
K
E
Y
M
E
P
Y
A
D
E
V
V
V
D
K
L
G
S
V
T
F
-
I
A
K
G
N
D
R
-
P
R
I
L
M
A
G
H
T
D
E
V
G
F
I
V
S
S
I
S
K
E
G
Y
L
T
F
N
T
L
G
G
W
W
S
Q
V
L
L
G
Q
R
V
V
V
R
T
C
K
G
-
M
V
H
G
I
I
A
S
K
P
P
H
I
L
P
P
D
E
R
K
K
I
V
E
A
R
D
M
F
I
D
I
G
A
T
S
E
E
E
A
E
E
S
G
V
K
V
G
D
P
I
V
P
W
S
P
F
S
V
I
Q
N
G
R
V
A
M
G
K
A
F
D
D
R
I
G
A
F
V
L
M
E
A
I
R
R
M
K
D
Q
G
-
I
-
E
H
P
N
T
V
Y
G
S
A
T
V
Q
E
E
V
G
L
R
G
A
Q
T
T
A
H
V
V
D
P
D
V
A
L
V
L
E
V
D
I
A
G
D
V
P
--
K
P
H
E
A
L
T
K
M
G
K
G
P
G
L
V
T
Y
D
R
S
M
I
P
N
Q
P
L
K
E
F
V
I
N
V
A
K
Q
A
Q
I
P
L
Q
L
S
Q
M
S
-
G
-
G
G
T
D
A
G
R
--
I
H
M
N
R
A
G
C
P
S
V
V
I
T
I
P
T
R
H
I
H
S
H
V
G
L
L
S
L
K
D
T
E
N
A
I
R
L
V
I
E
L
I
K
R
L
D
L
E
T
V
E
G
F
T
--
89
HHSearch
75.13
36%
-103
* C3 *
2WYR
2
?
A:
[2-332]
----
M
S
M
I
E
K
L
K
K
F
T
Q
I
P
G
I
S
G
Y
E
E
R
I
R
E
E
I
I
R
E
I
K
D
F
A
-
D
Y
K
V
D
A
I
G
N
L
I
V
-
E
L
G
E
--
G
E
E
R
I
L
F
M
A
H
M
D
E
I
G
L
L
I
T
G
I
T
D
E
G
K
L
R
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
R
H
V
N
V
V
T
E
K
G
-
I
L
D
G
V
I
G
A
T
P
P
H
L
------
K
S
V
I
P
W
Y
D
L
V
I
D
I
G
A
E
S
K
E
E
A
L
E
-
L
V
K
P
L
D
F
A
V
F
K
K
H
F
S
V
L
N
-
G
K
Y
V
S
T
R
G
L
D
D
R
F
G
V
V
A
L
I
E
A
I
K
D
L
--
V
D
-
H
-
E
L
E
G
K
V
I
F
A
F
T
V
Q
E
E
V
G
L
K
G
A
K
F
L
A
N
H
Y
Y
P
Q
Y
A
F
A
I
D
S
F
A
C
C
S
-
P
L
T
G
----
D
V
K
L
G
K
G
P
V
I
R
A
V
D
N
S
A
I
Y
S
R
D
L
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
G
V
T
G
---
G
G
T
D
A
S
A
--
F
Q
--
D
-
R
S
K
T
L
A
L
S
V
P
I
K
Y
L
H
S
E
V
E
T
L
H
L
N
D
L
E
K
L
V
K
L
I
E
A
L
A
F
E
L
-----------
7
PsiBlast_PDB
73.49
32%
-96
- C3 -
1YLO
2
?
A:
[6-345]
-------
L
S
L
L
K
A
L
S
E
A
D
A
I
A
S
S
E
Q
E
V
R
Q
I
L
L
E
E
A
A
R
L
Q
K
E
V
R
F
D
G
L
G
S
V
L
I
-
R
-
L
N
E
S
T
G
P
K
V
M
I
C
A
H
M
D
E
V
G
F
M
V
R
S
I
S
R
E
G
A
I
D
V
L
P
V
G
N
V
R
M
A
A
R
Q
L
Q
P
V
R
I
T
T
R
E
E
--------
C
K
I
P
G
L
L
--
D
G
D
R
Q
G
N
D
V
S
A
M
R
V
D
I
G
A
R
T
Y
D
E
V
M
Q
A
G
I
R
P
G
D
R
V
T
F
D
T
T
F
Q
V
L
P
H
Q
R
-
V
M
G
K
A
F
D
D
R
L
S
C
Y
L
L
V
T
L
L
R
E
L
--
H
D
-
A
-
E
L
P
A
E
V
W
L
V
A
S
S
S
E
E
V
G
L
R
G
G
Q
T
A
T
R
A
V
S
P
D
V
A
I
V
L
D
T
A
C
W
A
K
N
F
D
Y
G
A
A
N
-
H
R
Q
I
G
N
G
P
M
L
V
L
S
D
K
S
L
I
A
P
P
K
L
T
A
W
I
E
T
V
A
A
E
I
G
V
P
L
Q
A
D
M
F
S
-
N
-
G
G
T
D
G
G
A
--
V
H
L
T
G
T
G
V
P
T
L
V
M
G
P
A
T
R
H
G
H
C
A
A
S
I
A
D
C
R
D
I
L
Q
M
E
Q
L
L
S
A
L
I
Q
R
L
T
R
E
T
V
V
Q
L
T
--
8
PsiBlast_PDB
72.66
37%
-96
- C3 -
2WYR
2
?
A:
[8-325]
----------
L
K
K
F
T
Q
I
P
G
I
S
G
Y
E
E
R
I
R
E
E
I
I
R
E
I
K
D
F
A
D
-
Y
K
V
D
A
I
G
N
L
I
V
-
E
L
--
G
E
G
E
E
R
I
L
F
M
A
H
M
D
E
I
G
L
L
I
T
G
I
T
D
E
G
K
L
R
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
R
H
V
N
V
V
T
E
K
G
-
I
L
D
G
V
I
G
A
T
P
P
H
-
L
-----
K
S
V
I
P
W
Y
D
L
V
I
D
I
G
A
E
S
K
E
E
A
L
E
L
-
V
K
P
L
D
F
A
V
F
K
K
H
F
S
V
L
N
G
-
K
Y
V
S
T
R
G
L
D
D
R
F
G
V
V
A
L
I
E
A
I
K
D
L
--
V
D
-
H
-
E
L
E
G
K
V
I
F
A
F
T
V
Q
E
E
V
G
L
K
G
A
K
F
L
A
N
H
Y
Y
P
Q
Y
A
F
A
I
D
-
S
F
A
C
C
S
P
----
L
T
G
D
V
K
L
G
K
G
P
V
I
R
A
V
D
N
S
A
I
Y
S
R
D
L
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
-
G
V
T
-
G
-
G
G
T
D
A
S
A
--
F
Q
---
D
R
S
K
T
L
A
L
S
V
P
I
K
Y
L
H
S
E
V
E
T
L
H
L
N
D
L
E
K
L
V
K
L
I
------------------
52
PsiBlast_CBE
72.34
37%
-100
- C3 -
2WYR
2
?
C:
[8-325]
----------
L
K
K
F
T
Q
I
P
G
I
S
G
Y
E
E
R
I
R
E
E
I
I
R
E
I
K
D
F
A
D
-
Y
K
V
D
A
I
G
N
L
I
V
-
E
L
--
G
E
G
E
E
R
I
L
F
M
A
H
M
D
E
I
G
L
L
I
T
G
I
T
D
E
G
K
L
R
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
R
H
V
N
V
V
T
E
K
G
-
I
L
D
G
V
I
G
A
T
P
P
H
-
L
-----
K
S
V
I
P
W
Y
D
L
V
I
D
I
G
A
E
S
K
E
E
A
L
E
L
-
V
K
P
L
D
F
A
V
F
K
K
H
F
S
V
L
N
G
-
K
Y
V
S
T
R
G
L
D
D
R
F
G
V
V
A
L
I
E
A
I
K
D
L
--
V
D
-
H
-
E
L
E
G
K
V
I
F
A
F
T
V
Q
E
E
V
G
L
K
G
A
K
F
L
A
N
H
Y
Y
P
Q
Y
A
F
A
I
D
-
S
F
A
C
C
S
P
----
L
T
G
D
V
K
L
G
K
G
P
V
I
R
A
V
D
N
S
A
I
Y
S
R
D
L
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
-
G
V
T
-
G
-
G
G
T
D
A
S
A
--
F
Q
---
D
R
S
K
T
L
A
L
S
V
P
I
K
Y
L
H
S
E
V
E
T
L
H
L
N
D
L
E
K
L
V
K
L
I
------------------
9
PsiBlast_PDB
71.84
37%
-104
- C3 -
2CF4
2
?
A:
[8-325]
----------
L
K
K
F
T
Q
I
P
G
I
S
G
Y
E
E
R
I
R
E
E
I
I
R
E
I
K
D
F
A
D
-
Y
K
V
D
A
I
G
N
L
I
V
-
E
L
--
G
E
G
E
E
R
I
L
F
M
A
H
M
D
E
I
G
L
L
I
T
G
I
T
D
E
G
K
L
R
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
R
H
V
N
V
V
T
E
K
G
-
I
L
D
G
V
I
G
A
T
P
P
H
-
L
S
L
E
R
D
K
S
V
I
P
W
Y
D
L
V
I
D
I
G
A
E
S
K
E
E
A
L
E
L
-
V
K
P
L
D
F
A
V
F
K
K
H
F
S
V
L
N
G
-
K
Y
V
S
T
R
G
L
D
D
R
F
G
V
V
A
L
I
E
A
I
K
D
L
--
V
D
-
H
-
E
L
E
G
K
V
I
F
A
F
T
V
Q
E
E
V
G
L
K
G
A
K
F
L
A
N
H
Y
Y
P
Q
Y
A
F
A
I
D
-
S
F
A
C
C
S
P
----
L
T
G
D
V
K
L
G
K
G
P
V
I
R
A
V
D
N
S
A
I
Y
S
R
D
L
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
-
G
V
T
-
G
-
G
G
T
D
A
S
A
--
F
Q
---
D
R
S
K
T
L
A
L
S
V
P
I
K
Y
L
H
S
E
V
E
T
L
H
L
N
D
L
E
K
L
V
K
L
I
------------------
50
PsiBlast_CBE
71.70
37%
-97
- C3 -
2WYR
2
?
E:
[8-325]
----------
L
K
K
F
T
Q
I
P
G
I
S
G
Y
E
E
R
I
R
E
E
I
I
R
E
I
K
D
F
A
D
-
Y
K
V
D
A
I
G
N
L
I
V
-
E
L
--
G
E
G
E
E
R
I
L
F
M
A
H
M
D
E
I
G
L
L
I
T
G
I
T
D
E
G
K
L
R
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
R
H
V
N
V
V
T
E
K
G
-
I
L
D
G
V
I
G
A
T
P
P
H
-
L
-----
K
S
V
I
P
W
Y
D
L
V
I
D
I
G
A
E
S
K
E
E
A
L
E
L
-
V
K
P
L
D
F
A
V
F
K
K
H
F
S
V
L
N
G
-
K
Y
V
S
T
R
G
L
D
D
R
F
G
V
V
A
L
I
E
A
I
K
D
L
--
V
D
-
H
-
E
L
E
G
K
V
I
F
A
F
T
V
Q
E
E
V
G
L
K
G
A
K
F
L
A
N
H
Y
Y
P
Q
Y
A
F
A
I
D
-
S
F
A
C
C
S
P
----
L
T
G
D
V
K
L
G
K
G
P
V
I
R
A
V
D
N
S
A
I
Y
S
R
D
L
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
-
G
V
T
-
G
-
G
G
T
D
A
S
A
--
F
Q
---
D
R
S
K
T
L
A
L
S
V
P
I
K
Y
L
H
S
E
V
E
T
L
H
L
N
D
L
E
K
L
V
K
L
I
------------------
48
PsiBlast_CBE
71.66
37%
-98
- C3 -
2WYR
2
?
G:
[8-325]
----------
L
K
K
F
T
Q
I
P
G
I
S
G
Y
E
E
R
I
R
E
E
I
I
R
E
I
K
D
F
A
D
-
Y
K
V
D
A
I
G
N
L
I
V
-
E
L
--
G
E
G
E
E
R
I
L
F
M
A
H
M
D
E
I
G
L
L
I
T
G
I
T
D
E
G
K
L
R
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
R
H
V
N
V
V
T
E
K
G
-
I
L
D
G
V
I
G
A
T
P
P
H
-
L
S
------
V
I
P
W
Y
D
L
V
I
D
I
G
A
E
S
K
E
E
A
L
E
L
-
V
K
P
L
D
F
A
V
F
K
K
H
F
S
V
L
N
G
-
K
Y
V
S
T
R
G
L
D
D
R
F
G
V
V
A
L
I
E
A
I
K
D
L
--
V
D
-
H
-
E
L
E
G
K
V
I
F
A
F
T
V
Q
E
E
V
G
L
K
G
A
K
F
L
A
N
H
Y
Y
P
Q
Y
A
F
A
I
D
-
S
F
A
C
C
S
P
----
L
T
G
D
V
K
L
G
K
G
P
V
I
R
A
V
D
N
S
A
I
Y
S
R
D
L
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
-
G
V
T
-
G
-
G
G
T
D
A
S
A
--
F
Q
---
D
R
S
K
T
L
A
L
S
V
P
I
K
Y
L
H
S
E
V
E
T
L
H
L
N
D
L
E
K
L
V
K
L
I
------------------
43
PsiBlast_CBE
71.56
37%
-101
- C3 -
2WYR
5
?
L:
[8-325]
----------
L
K
K
F
T
Q
I
P
G
I
S
G
Y
E
E
R
I
R
E
E
I
I
R
E
I
K
D
F
A
D
-
Y
K
V
D
A
I
G
N
L
I
V
-
E
L
--
G
E
G
E
E
R
I
L
F
M
A
H
M
D
E
I
G
L
L
I
T
G
I
T
D
E
G
K
L
R
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
R
H
V
N
V
V
T
E
K
G
-
I
L
D
G
V
I
G
A
T
P
P
H
-
L
S
------
V
I
P
W
Y
D
L
V
I
D
I
G
A
E
S
K
E
E
A
L
E
L
-
V
K
P
L
D
F
A
V
F
K
K
H
F
S
V
L
N
G
-
K
Y
V
S
T
R
G
L
D
D
R
F
G
V
V
A
L
I
E
A
I
K
D
L
--
V
D
-
H
-
E
L
E
G
K
V
I
F
A
F
T
V
Q
E
E
V
G
L
K
G
A
K
F
L
A
N
H
Y
Y
P
Q
Y
A
F
A
I
D
-
S
F
A
C
C
S
P
----
L
T
G
D
V
K
L
G
K
G
P
V
I
R
A
V
D
N
S
A
I
Y
S
R
D
L
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
-
G
V
T
-
G
-
G
G
T
D
A
S
A
--
F
Q
---
D
R
S
K
T
L
A
L
S
V
P
I
K
Y
L
H
S
E
V
E
T
L
H
L
N
D
L
E
K
L
V
K
L
I
------------------
49
PsiBlast_CBE
71.50
37%
-96
- C3 -
2WYR
2
?
F:
[8-325]
----------
L
K
K
F
T
Q
I
P
G
I
S
G
Y
E
E
R
I
R
E
E
I
I
R
E
I
K
D
F
A
D
-
Y
K
V
D
A
I
G
N
L
I
V
-
E
L
--
G
E
G
E
E
R
I
L
F
M
A
H
M
D
E
I
G
L
L
I
T
G
I
T
D
E
G
K
L
R
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
R
H
V
N
V
V
T
E
K
G
-
I
L
D
G
V
I
G
A
T
P
P
H
-
L
S
------
V
I
P
W
Y
D
L
V
I
D
I
G
A
E
S
K
E
E
A
L
E
L
-
V
K
P
L
D
F
A
V
F
K
K
H
F
S
V
L
N
G
-
K
Y
V
S
T
R
G
L
D
D
R
F
G
V
V
A
L
I
E
A
I
K
D
L
--
V
D
-
H
-
E
L
E
G
K
V
I
F
A
F
T
V
Q
E
E
V
G
L
K
G
A
K
F
L
A
N
H
Y
Y
P
Q
Y
A
F
A
I
D
-
S
F
A
C
C
S
P
----
L
T
G
D
V
K
L
G
K
G
P
V
I
R
A
V
D
N
S
A
I
Y
S
R
D
L
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
-
G
V
T
-
G
-
G
G
T
D
A
S
A
--
F
Q
---
D
R
S
K
T
L
A
L
S
V
P
I
K
Y
L
H
S
E
V
E
T
L
H
L
N
D
L
E
K
L
V
K
L
I
------------------
51
PsiBlast_CBE
71.40
37%
-97
- C3 -
2WYR
2
?
D:
[8-325]
----------
L
K
K
F
T
Q
I
P
G
I
S
G
Y
E
E
R
I
R
E
E
I
I
R
E
I
K
D
F
A
D
-
Y
K
V
D
A
I
G
N
L
I
V
-
E
L
--
G
E
G
E
E
R
I
L
F
M
A
H
M
D
E
I
G
L
L
I
T
G
I
T
D
E
G
K
L
R
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
R
H
V
N
V
V
T
E
K
G
-
I
L
D
G
V
I
G
A
T
P
P
H
-
L
S
------
V
I
P
W
Y
D
L
V
I
D
I
G
A
E
S
K
E
E
A
L
E
L
-
V
K
P
L
D
F
A
V
F
K
K
H
F
S
V
L
N
G
-
K
Y
V
S
T
R
G
L
D
D
R
F
G
V
V
A
L
I
E
A
I
K
D
L
--
V
D
-
H
-
E
L
E
G
K
V
I
F
A
F
T
V
Q
E
E
V
G
L
K
G
A
K
F
L
A
N
H
Y
Y
P
Q
Y
A
F
A
I
D
-
S
F
A
C
C
S
P
----
L
T
G
D
V
K
L
G
K
G
P
V
I
R
A
V
D
N
S
A
I
Y
S
R
D
L
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
-
G
V
T
-
G
-
G
G
T
D
A
S
A
--
F
Q
---
D
R
S
K
T
L
A
L
S
V
P
I
K
Y
L
H
S
E
V
E
T
L
H
L
N
D
L
E
K
L
V
K
L
I
------------------
53
PsiBlast_CBE
71.35
37%
-98
- C3 -
2WYR
2
?
B:
[8-325]
----------
L
K
K
F
T
Q
I
P
G
I
S
G
Y
E
E
R
I
R
E
E
I
I
R
E
I
K
D
F
A
D
-
Y
K
V
D
A
I
G
N
L
I
V
-
E
L
--
G
E
G
E
E
R
I
L
F
M
A
H
M
D
E
I
G
L
L
I
T
G
I
T
D
E
G
K
L
R
F
R
K
V
G
G
I
D
D
R
L
L
Y
G
R
H
V
N
V
V
T
E
K
G
-
I
L
D
G
V
I
G
A
T
P
P
H
-
L
S
------
V
I
P
W
Y
D
L
V
I
D
I
G
A
E
S
K
E
E
A
L
E
L
-
V
K
P
L
D
F
A
V
F
K
K
H
F
S
V
L
N
G
-
K
Y
V
S
T
R
G
L
D
D
R
F
G
V
V
A
L
I
E
A
I
K
D
L
--
V
D
-
H
-
E
L
E
G
K
V
I
F
A
F
T
V
Q
E
E
V
G
L
K
G
A
K
F
L
A
N
H
Y
Y
P
Q
Y
A
F
A
I
D
-
S
F
A
C
C
S
P
----
L
T
G
D
V
K
L
G
K
G
P
V
I
R
A
V
D
N
S
A
I
Y
S
R
D
L
A
R
K
V
W
S
I
A
E
K
N
G
I
E
I
Q
I
-
G
V
T
-
G
-
G
G
T
D
A
S
A
--
F
Q
---
D
R
S
K
T
L
A
L
S
V
P
I
K
Y
L
H
S
E
V
E
T
L
H
L
N
D
L
E
K
L
V
K
L
I
------------------
92
HHSearch
70.40
36%
-88
- C3 -
1VHO
4
?
A:
[5-335]
----
M
E
T
G
K
L
L
M
E
L
S
N
L
D
G
P
S
G
Y
E
T
N
V
V
S
Y
I
K
S
V
I
E
P
F
V
D
E
A
K
T
T
R
H
G
S
L
I
G
-
Y
K
K
G
K
-
G
I
G
K
L
A
F
F
A
H
V
D
E
I
G
F
V
V
S
K
V
E
-
G
Q
F
A
R
L
E
P
V
--------
Y
A
S
K
V
R
I
Y
T
K
N
G
-
I
E
R
G
V
I
G
M
L
A
P
H
L
Q
D
S
E
S
R
K
K
V
P
T
Y
D
E
I
F
V
D
L
S
L
C
------
E
R
G
V
R
V
G
D
I
A
V
I
D
Q
T
A
F
E
-
T
-
N
G
K
V
V
G
K
A
L
D
N
R
A
S
C
G
V
L
V
K
V
L
E
F
L
--
K
R
-
Y
-
D
H
P
W
D
V
Y
V
V
F
S
V
Q
E
E
T
G
C
L
G
A
L
T
G
A
Y
E
I
N
P
D
A
A
I
V
M
D
V
T
F
A
S
E
P
P
F
S
D
----
H
I
E
L
G
K
G
P
V
I
G
L
G
P
---
V
V
D
R
N
L
V
Q
K
I
I
E
I
A
K
K
H
N
V
S
L
Q
E
E
A
V
G
G
R
-----
T
D
F
--
V
Q
L
V
R
N
G
V
R
T
S
L
I
S
I
P
L
K
Y
M
H
T
P
V
E
M
V
D
P
R
D
V
E
E
L
A
R
L
L
S
L
V
A
V
E
L
E
----------
14
PsiBlast_PDB
69.54
35%
-85
- C3 -
1VHO
4
?
A:
[6-335]
-----
E
T
G
K
L
L
M
E
L
S
N
L
D
G
P
S
G
Y
E
T
N
V
V
S
Y
I
K
S
V
I
E
P
F
V
D
E
A
K
T
T
R
H
G
S
L
I
G
-
Y
K
K
G
K
G
I
G
K
L
A
F
F
A
-
H
V
D
E
I
G
F
V
V
S
K
V
E
G
Q
-
F
A
R
L
E
P
V
--------
Y
A
S
K
V
R
I
Y
T
K
N
G
-
I
E
R
G
V
I
G
M
L
A
P
H
L
Q
D
S
E
S
R
K
K
V
P
T
Y
D
E
I
F
V
D
L
S
L
C
E
R
------
G
V
R
V
G
D
I
A
V
--
I
D
Q
T
A
F
E
T
N
G
K
V
V
G
K
A
L
D
N
R
A
S
C
G
V
L
V
K
V
L
E
F
L
--
K
R
-
Y
-
D
H
P
W
D
V
Y
V
V
F
S
V
Q
E
E
T
G
C
L
G
A
L
T
G
A
Y
E
I
N
P
D
A
A
I
V
M
D
V
T
F
A
S
E
P
P
F
S
D
H
I
E
----
L
G
K
G
P
---
V
I
G
L
G
P
V
V
D
R
N
L
V
Q
K
I
I
E
I
A
K
K
H
N
V
S
L
Q
E
E
A
V
G
-
G
R----
T
D
F
--
V
Q
L
V
R
N
G
V
R
T
S
L
I
S
I
P
L
K
Y
M
H
T
P
V
E
M
V
D
P
R
D
V
E
E
L
A
R
L
L
S
L
V
A
V
E
L
E
----------
37
PsiBlast_CBE
68.98
38%
-11
- C3 -
3KL9
2
?
D:
[6-354]
-------
F
S
K
I
K
E
V
T
E
L
A
A
V
S
G
H
E
A
P
V
R
A
Y
L
R
E
K
L
T
P
H
V
D
E
V
V
T
D
G
L
G
G
I
F
G
I
K
H
S
E
A
V
D
A
P
R
V
L
V
A
S
H
M
D
E
V
G
F
M
V
S
E
I
K
P
D
G
T
F
R
V
V
E
I
G
G
W
N
P
M
V
V
S
S
Q
R
F
K
L
L
T
R
D
G
H
E
I
P
V
I
S
G
---------------
P
A
I
A
D
I
V
F
D
G
G
F
A
D
K
A
E
A
E
S
F
G
I
R
P
G
D
T
I
V
P
D
S
S
A
I
L
T
A
N
E
K
N
I
I
S
K
A
W
D
N
R
Y
G
V
L
M
V
S
E
L
A
E
A
L
--
S
G
-
Q
-
K
L
G
N
E
L
Y
L
G
S
N
V
Q
E
E
V
G
L
R
G
A
H
T
S
T
T
K
F
D
P
E
V
F
L
A
V
D
C
S
P
A
G
D
V
Y
G
-----
G
Q
G
K
I
G
D
G
T
L
I
R
F
Y
D
P
G
H
L
L
L
P
G
M
K
D
F
L
L
T
T
A
E
E
A
G
I
K
Y
Q
Y
-
Y
C
G
-
K
-
G
G
T
D
A
G
A
--
A
H
L
K
N
G
G
V
P
S
T
T
I
G
V
C
A
R
Y
I
H
S
H
Q
T
L
Y
A
M
D
D
F
L
E
A
Q
A
F
L
Q
A
L
V
K
K
L
D
R
S
T
V
D
L
I
K
H
-
36
PsiBlast_CBE
68.89
38%
-12
- C3 -
3KL9
2
?
E:
[6-354]
-------
F
S
K
I
K
E
V
T
E
L
A
A
V
S
G
H
E
A
P
V
R
A
Y
L
R
E
K
L
T
P
H
V
D
E
V
V
T
D
G
L
G
G
I
F
G
I
K
H
S
E
A
V
D
A
P
R
V
L
V
A
S
H
M
D
E
V
G
F
M
V
S
E
I
K
P
D
G
T
F
R
V
V
E
I
G
G
W
N
P
M
V
V
S
S
Q
R
F
K
L
L
T
R
D
G
H
E
I
P
V
I
S
G
---------------
P
A
I
A
D
I
V
F
D
G
G
F
A
D
K
A
E
A
E
S
F
G
I
R
P
G
D
T
I
V
P
D
S
S
A
I
L
T
A
N
E
K
N
I
I
S
K
A
W
D
N
R
Y
G
V
L
M
V
S
E
L
A
E
A
L
--
S
G
-
Q
-
K
L
G
N
E
L
Y
L
G
S
N
V
Q
E
E
V
G
L
R
G
A
H
T
S
T
T
K
F
D
P
E
V
F
L
A
V
D
C
S
P
A
G
D
V
Y
G
-----
G
Q
G
K
I
G
D
G
T
L
I
R
F
Y
D
P
G
H
L
L
L
P
G
M
K
D
F
L
L
T
T
A
E
E
A
G
I
K
Y
Q
Y
-
Y
C
G
-
K
-
G
G
T
D
A
G
A
--
A
H
L
K
N
G
G
V
P
S
T
T
I
G
V
C
A
R
Y
I
H
S
H
Q
T
L
Y
A
M
D
D
F
L
E
A
Q
A
F
L
Q
A
L
V
K
K
L
D
R
S
T
V
D
L
I
K
H
-
39
PsiBlast_CBE
68.79
38%
-11
- C3 -
3KL9
2
?
B:
[6-354]
-------
F
S
K
I
K
E
V
T
E
L
A
A
V
S
G
H
E
A
P
V
R
A
Y
L
R
E
K
L
T
P
H
V
D
E
V
V
T
D
G
L
G
G
I
F
G
I
K
H
S
E
A
V
D
A
P
R
V
L
V
A
S
H
M
D
E
V
G
F
M
V
S
E
I
K
P
D
G
T
F
R
V
V
E
I
G
G
W
N
P
M
V
V
S
S
Q
R
F
K
L
L
T
R
D
G
H
E
I
P
V
I
S
G
---------------
P
A
I
A
D
I
V
F
D
G
G
F
A
D
K
A
E
A
E
S
F
G
I
R
P
G
D
T
I
V
P
D
S
S
A
I
L
T
A
N
E
K
N
I
I
S
K
A
W
D
N
R
Y
G
V
L
M
V
S
E
L
A
E
A
L
--
S
G
-
Q
-
K
L
G
N
E
L
Y
L
G
S
N
V
Q
E
E
V
G
L
R
G
A
H
T
S
T
T
K
F
D
P
E
V
F
L
A
V
D
C
S
P
A
G
D
V
Y
G
-----
G
Q
G
K
I
G
D
G
T
L
I
R
F
Y
D
P
G
H
L
L
L
P
G
M
K
D
F
L
L
T
T
A
E
E
A
G
I
K
Y
Q
Y
-
Y
C
G
-
K
-
G
G
T
D
A
G
A
--
A
H
L
K
N
G
G
V
P
S
T
T
I
G
V
C
A
R
Y
I
H
S
H
Q
T
L
Y
A
M
D
D
F
L
E
A
Q
A
F
L
Q
A
L
V
K
K
L
D
R
S
T
V
D
L
I
K
H
-