@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu29020: (2016-07-16 )
MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHLIKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNAKDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPVVKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSLVLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYSDEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARMKHPSAV
Atome Classification :
(41 SA)
.........10........--20.--.--.---.--.--...30....-....40........50......-..60.-.......70........80........90........100.......110.......120......-.130.......140.......150.......160.......170.......180.......190--.......200.......210.......220.......230.......240......-.250........260...-------.-------...270.......280.......290.......300.......310.......320.......330.......340
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
V
K
V
A
IN
G
F
G
R
I
G
R
M
V
F
R
--
K
A
M--L--D---D--Q--
I
Q
V
V
A
I
NAS-Y
S
A
E
T
L
A
H
L
I
K
YDTIHGRYDKE-VVAGE-
D
S
L
I
VNG
K
K
V
L
L
LNSRDPKQLPWREY
D
I
D
I
V
V
EATGKFNAKDKAM
G
H
IEAGA
K
K
V
I
L
TAPGKNE
D
V
-
T
I
V
M
GVNEDQFDAER
H
V
I
I
SNASC
T
T
N
C
L
A
P
V
V
K
V
L
D
E
E
FGIESG
L
M
T
T
V
H
AYTNDQKNID
N
P
H
--
K
D
L
R
R
A
R
ACGESIIPTTT
G
A
A
K
A
L
S
L
V
L
P
H
LKGKL
H
G
L
A
L
RVPVPN
V
S
L
V
D
L
V
V
DL-KTD-V
T
A
E
E
V
N
E
A
F
K
R
A
A
-------
K
-------T
S
M
Y
G
V
L
DYSDE
P
L
V
STDYNTNP
H
S
A
V
I
D
G
L
T
T
M
V
MEDR
K
V
K
V
L
A
W
YDNEWGYS
C
R
V
V
D
L
I
R
H
V
A
A
RMKHPSAV
117
HHSearch
97.91
73%
-125
- C1 -
4DIB
1
?
A:
[4-337]
-
M
T
R
V
A
I
N
G
F
G
R
I
G
R
M
V
F
R
--
Q
A
I
--
K
--
E
---
S
--
A
--
F
E
I
V
A
I
N
A
S
-
Y
P
S
E
T
L
A
H
L
I
K
Y
D
T
V
H
G
K
F
D
G
T
-
V
E
A
F
E
-
D
H
L
L
V
D
G
K
M
I
R
L
L
N
N
R
D
P
K
E
L
P
W
T
D
L
G
V
E
V
V
I
E
A
T
G
K
F
N
S
K
E
K
A
I
L
H
V
E
A
G
A
K
K
V
I
L
T
A
P
G
K
N
E
D
V
-
T
I
V
V
G
V
N
E
D
Q
L
D
I
T
K
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
V
K
V
L
D
E
Q
F
G
I
E
N
G
L
M
T
T
V
H
A
Y
---------------
L
R
R
A
R
A
C
G
Q
S
I
I
P
T
T
T
G
A
A
K
A
L
A
K
V
L
P
H
L
N
G
K
L
H
G
M
A
L
R
V
P
T
P
N
V
S
L
V
D
L
V
V
D
V
-
K
R
D
-
V
T
V
E
A
I
N
D
A
F
K
T
V
A
-------
N
-------
G
A
L
K
G
I
V
E
F
S
E
E
P
L
V
S
I
D
F
N
T
N
T
H
S
A
I
I
D
G
L
S
T
M
V
M
G
D
R
K
V
K
V
L
A
W
Y
D
N
E
W
G
Y
S
R
R
V
V
D
L
V
T
L
V
V
D
E
L
A
-----
1
PsiBlast_PDB
92.51
74%
-119
- C1 -
4DIB
1
?
A:
[6-324]
---
R
V
A
I
N
G
F
G
R
I
G
R
M
V
F
R
--
Q
A
I
--
K
--
E
---
S
--
A
--
F
E
I
V
A
I
N
A
S
-
Y
P
S
E
T
L
A
H
L
I
K
Y
D
T
V
H
G
K
F
D
G
T
-
V
E
A
F
E
-
D
H
L
L
V
D
G
K
M
I
R
L
L
N
N
R
D
P
K
E
L
P
W
T
D
L
G
V
E
V
V
I
E
A
T
G
K
F
N
S
K
E
K
A
I
L
H
V
E
A
G
A
K
K
V
I
L
T
A
P
G
K
N
E
D
V
-
T
I
V
V
G
V
N
E
D
Q
L
D
I
T
K
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
V
K
V
L
D
E
Q
F
G
I
E
N
G
L
M
T
T
V
H
A
Y
---------------
L
R
R
A
R
A
C
G
Q
S
I
I
P
T
T
T
G
A
A
K
A
L
A
K
V
L
P
H
L
N
G
K
L
H
G
M
A
L
R
V
P
T
P
N
V
S
L
V
D
L
V
V
D
V
-
K
R
D
-
V
T
V
E
A
I
N
D
A
F
K
T
V
A
-------
N
-------
G
A
L
K
G
I
V
E
F
S
E
E
P
L
V
S
I
D
F
N
T
N
T
H
S
A
I
I
D
G
L
S
T
M
V
M
G
D
R
K
V
K
V
L
A
W
Y
D
N
E
W
G
Y
S
R
R
------------------
24
PsiBlast_CBE
92.02
74%
-122
- C1 -
4DIB
2
?
C:
[6-324]
---
R
V
A
I
N
G
F
G
R
I
G
R
M
V
F
R
--
Q
A
I
--
K
--
E
---
S
--
A
--
F
E
I
V
A
I
N
A
S
-
Y
P
S
E
T
L
A
H
L
I
K
Y
D
T
V
H
G
K
F
D
G
T
-
V
E
A
F
E
-
D
H
L
L
V
D
G
K
M
I
R
L
L
N
N
R
D
P
K
E
L
P
W
T
D
L
G
V
E
V
V
I
E
A
T
G
K
F
N
S
K
E
K
A
I
L
H
V
E
A
G
A
K
K
V
I
L
T
A
P
G
K
N
E
D
V
-
T
I
V
V
G
V
N
E
D
Q
L
D
I
T
K
H
T
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
V
K
V
L
D
E
Q
F
G
I
E
N
G
L
M
T
T
V
H
A
----------------
L
R
R
A
R
A
C
G
Q
S
I
I
P
T
T
T
G
A
A
K
A
L
A
K
V
L
P
H
L
N
G
K
L
H
G
M
A
L
R
V
P
T
P
N
V
S
L
V
D
L
V
V
D
V
-
K
R
D
-
V
T
V
E
A
I
N
D
A
F
K
T
V
A
-------
N
-------
G
A
L
K
G
I
V
E
F
S
E
E
P
L
V
S
I
D
F
N
T
N
T
H
S
A
I
I
D
G
L
S
T
M
V
M
G
D
R
K
V
K
V
L
A
W
Y
D
N
E
W
G
Y
S
R
R
------------------
36
PsiBlast_CBE
91.37
61%
-104
- C1 -
4DBV
3
G3P_GEOSE
P:
[2-332]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
L
--
K
--
N
---
P
--
D
--
I
E
V
V
A
V
N
D
T
-
G
G
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
-
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
-------
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
-------
33
PsiBlast_CBE
91.21
61%
-107
- C1 -
1GD1
4
G3P_GEOSE
P:
[2-332]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
L
--
K
--
N
---
P
--
D
--
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
-
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
-------
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
-------
8
PsiBlast_PDB
91.20
61%
-108
- C1 -
2DBV
4
G3P_GEOSE
O:
[2-332]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
L
--
K
--
N
---
P
--
D
--
I
E
V
V
A
V
N
G
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
-
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
-------
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
-------
7
PsiBlast_PDB
91.08
61%
-106
- C1 -
1DBV
3
G3P_GEOSE
O:
[2-332]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
L
--
K
--
N
---
P
--
D
--
I
E
V
V
A
V
N
G
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
-
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
-------
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
-------
37
PsiBlast_CBE
91.01
61%
-105
- C1 -
3DBV
3
G3P_GEOSE
R:
[2-332]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
L
--
K
--
N
---
P
--
D
--
I
E
V
V
A
V
N
D
T
-
G
G
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
-
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
-------
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
-------
45
PsiBlast_CBE
90.98
61%
-104
- C1 -
1DBV
3
G3P_GEOSE
P:
[2-332]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
L
--
K
--
N
---
P
--
D
--
I
E
V
V
A
V
N
G
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
-
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
-------
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
-------
57
PsiBlast_CBE
90.87
61%
-101
- C1 -
1NQ5
2
G3P_GEOSE
A:
[2-332]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
L
--
K
--
N
---
P
--
D
--
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
S
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
-
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
-------
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
-------
41
PsiBlast_CBE
90.86
61%
-107
- C1 -
2DBV
4
G3P_GEOSE
Q:
[2-332]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
L
--
K
--
N
---
P
--
D
--
I
E
V
V
A
V
N
G
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
-
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
-------
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
-------
49
PsiBlast_CBE
90.46
61%
-102
- C1 -
1NPT
3
G3P_GEOSE
R:
[2-332]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
L
--
K
--
N
---
P
--
D
--
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
A
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
-
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
-------
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
-------
42
PsiBlast_CBE
90.41
61%
-107
- C1 -
2DBV
4
G3P_GEOSE
P:
[2-332]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
L
--
K
--
N
---
P
--
D
--
I
E
V
V
A
V
N
G
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
-
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
-------
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
-------
118
HHSearch
90.39
62%
-100
* C1 *
3CMC
14
G3P_GEOSE
O:
[1-333]
-
A
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
L
--
K
--
N
---
P
--
D
--
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
-
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
-------
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
G
------
26
PsiBlast_CBE
90.34
61%
-102
- C1 -
3CMC
5
G3P_GEOSE
Q:
[2-332]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
L
--
K
--
N
---
P
--
D
--
I
E
V
V
A
V
N
D
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
-
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
-------
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
-------
34
PsiBlast_CBE
90.33
61%
-102
- C1 -
4DBV
3
G3P_GEOSE
R:
[2-332]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
L
--
K
--
N
---
P
--
D
--
I
E
V
V
A
V
N
D
T
-
G
G
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
-
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
-------
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
-------
35
PsiBlast_CBE
90.29
61%
-102
- C1 -
4DBV
3
G3P_GEOSE
Q:
[2-332]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
L
--
K
--
N
---
P
--
D
--
I
E
V
V
A
V
N
D
T
-
G
G
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
-
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
-------
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
-------
39
PsiBlast_CBE
90.10
61%
-105
- C1 -
3DBV
3
G3P_GEOSE
P:
[2-332]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
L
--
K
--
N
---
P
--
D
--
I
E
V
V
A
V
N
D
T
-
G
G
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
-
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
-------
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
-------
5
PsiBlast_PDB
90.04
61%
-105
- C1 -
3DBV
3
G3P_GEOSE
O:
[2-332]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
L
--
K
--
N
---
P
--
D
--
I
E
V
V
A
V
N
D
T
-
G
G
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
-
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
-------
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
-------
44
PsiBlast_CBE
90.01
61%
-105
- C1 -
1DBV
3
G3P_GEOSE
Q:
[2-332]
--
V
K
V
G
I
N
G
F
G
R
I
G
R
N
V
F
R
--
A
A
L
--
K
--
N
---
P
--
D
--
I
E
V
V
A
V
N
G
L
-
T
D
A
N
T
L
A
H
L
L
K
Y
D
S
V
H
G
R
L
D
A
E
-
V
S
V
N
G
-
N
N
L
V
V
N
G
K
E
I
I
V
K
A
E
R
D
P
E
N
L
A
W
G
E
I
G
V
D
I
V
V
E
S
T
G
R
F
T
K
R
E
D
A
A
K
H
L
E
A
G
A
K
K
V
I
I
S
A
P
A
K
N
E
D
I
-
T
I
V
M
G
V
N
Q
D
K
Y
D
P
K
A
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
F
A
K
V
L
H
E
Q
F
G
I
V
R
G
M
M
T
T
V
H
S
Y
T
N
D
Q
R
I
L
D
A
S
H
--
K
D
L
R
R
A
R
A
A
A
E
S
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
L
P
E
L
K
G
K
L
N
G
M
A
M
R
V
P
T
P
N
V
S
V
V
D
L
V
A
E
L
-
E
K
E
-
V
T
V
E
E
V
N
A
A
L
K
A
A
A
-------
E
-------
G
E
L
K
G
I
L
A
Y
S
E
E
P
L
V
S
R
D
Y
N
G
S
T
V
S
S
T
I
D
A
L
S
T
M
V
I
D
G
K
M
V
K
V
V
S
W
Y
D
N
E
T
G
Y
S
H
R
V
V
D
L
A
A
Y
I
A
S
K
-------
18
PsiBlast_PDB
86.29
54%
-103
- C1 -
1VC2
1
?
A:
[1-326]
--
M
K
V
G
I
N
G
F
G
R
I
G
R
Q
V
F
R
---
I
L
--
H
--
E
---
R
--
G
--
V
E
V
A
L
I
N
D
L
-
T
D
N
K
T
L
A
H
L
L
K
Y
D
S
T
Y
G
R
F
P
G
A
-
V
G
Y
D
E
-
E
N
L
Y
V
D
G
K
A
I
R
A
T
A
I
K
D
P
R
E
I
P
W
K
Q
A
G
V
G
V
V
V
E
S
T
G
V
F
T
D
G
E
K
A
R
A
H
L
E
A
G
A
K
K
V
I
I
T
A
P
A
K
N
E
D
I
-
T
V
V
L
G
V
N
H
E
Q
Y
D
P
A
K
H
H
I
L
S
N
A
S
C
T
T
N
S
L
A
P
V
M
K
V
L
E
K
A
F
G
V
E
K
A
L
M
T
T
V
H
S
Y
T
N
D
Q
R
L
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
L
N
I
I
P
T
T
T
G
A
A
K
A
T
A
L
V
L
P
S
L
K
G
R
F
D
G
M
A
L
R
V
P
T
P
T
G
S
I
S
D
I
T
A
L
L
-
K
R
E
-
V
T
A
E
E
V
N
A
A
L
K
A
A
A
-------
E
-------
G
P
L
K
G
I
L
A
Y
T
E
D
E
I
V
L
R
D
I
V
M
D
P
H
S
S
I
V
D
G
K
L
T
K
A
I
G
N
L
-
V
K
V
F
A
W
Y
D
N
E
W
G
Y
A
N
R
V
A
D
L
V
E
L
V
----------
13
PsiBlast_PDB
84.22
53%
-83
- C1 -
2EP7
1
G3P_AQUAE
A:
[3-340]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
--
A
S
W
--
G
--
R
---
E
--
E
--
I
E
I
V
A
I
N
D
L
-
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
-
V
E
A
K
D
-
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
D
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
K
N
P
D
I
-
T
V
V
L
G
V
N
E
E
K
Y
N
P
K
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
--
K
D
F
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
A
P
-
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
K
Y
R
E
SG
K
-------
V
Y
L
K
E
I
L
Q
Y
C
E
D
P
I
V
S
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
I
-
D
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
R
-------
58
PsiBlast_CBE
84.20
53%
-82
- C1 -
2EP7
1
G3P_AQUAE
B:
[2-340]
-
A
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
--
A
S
W
--
G
--
R
---
E
--
E
--
I
E
I
V
A
I
N
D
L
-
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
-
V
E
A
K
D
-
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
D
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
K
N
P
D
I
-
T
V
V
L
G
V
N
E
E
K
Y
N
P
K
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
--
K
D
F
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
A
P
-
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
K
Y
R
E
SG
K
-------
V
Y
L
K
E
I
L
Q
Y
C
E
D
P
I
V
S
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
I
-
D
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
R
-------
114
HHSearch
84.11
55%
-79
- C1 -
2EP7
1
G3P_AQUAE
A:
[3-340]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
--
A
S
W
--
G
--
R
---
E
--
E
--
I
E
I
V
A
I
N
D
L
-
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
-
V
E
A
K
D
-
D
S
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
D
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
K
N
P
D
I
-
T
V
V
L
G
V
N
E
E
K
Y
N
P
K
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
--
K
D
F
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
-
N
K
A
P
S
S
V
E
E
V
N
E
K
F
R
E
A
A
-------
Q
K
Y
R
E
SGK
V
Y
L
K
E
I
L
Q
Y
C
E
D
P
I
V
S
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
-
I
D
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
R
-------
113
HHSearch
79.94
48%
-65
- C1 -
4LSM
5
?
A:
[16-346]
-
T
I
K
I
G
I
N
G
F
G
R
I
G
R
M
V
F
R
--
A
A
Q
--
H
--
R
---
N
--
D
--
I
E
I
V
G
I
N
D
L
-
L
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
Y
G
G
M
-
V
E
V
R
E
-
G
A
L
V
V
N
G
K
K
I
R
V
T
S
E
R
D
P
A
N
L
K
W
N
E
V
G
A
V
V
V
V
E
S
T
G
L
F
L
T
D
E
T
A
R
K
H
I
Q
A
G
A
K
K
V
V
M
T
G
P
P
K
D
D
T
P
-
M
F
V
M
G
V
N
N
T
M
Y
K
G
--
Q
E
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
I
I
H
E
K
F
G
I
V
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
Q-
K
D
W
R
G
G
R
G
A
A
Q
N
I
I
P
S
A
T
G
A
A
K
A
V
G
K
V
I
P
A
L
N
G
R
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
A
R
L
-
E
R
P
-
A
T
Y
E
Q
I
C
A
A
I
K
A
A
S
-------
E
-------
G
E
L
K
G
I
L
G
Y
T
E
D
E
V
V
S
T
D
M
N
G
V
A
L
T
S
V
F
D
V
K
A
G
I
S
L
N
D
R
F
V
K
L
I
S
W
Y
D
N
E
T
G
Y
S
H
K
V
L
D
L
V
A
Y
I
S
A
H
-------
110
HHSearch
77.12
46%
-24
- C1 -
3CPS
1
?
A:
[18-353]
--
G
T
L
G
I
N
G
F
G
R
I
G
R
L
V
L
R
--
A
C
M
--
E
--
R
---
N
--
D
--
I
T
V
V
A
I
N
D
P
F
M
D
V
E
Y
M
A
Y
L
L
K
Y
D
S
V
H
G
N
F
N
G
T
-
V
E
V
S
G
--
D
L
C
I
N
G
K
V
V
K
V
F
Q
A
K
D
P
A
E
I
P
W
G
A
S
G
A
Q
I
V
C
E
S
T
G
V
F
T
T
E
E
K
A
S
L
H
L
K
G
G
A
K
K
V
I
I
S
A
P
P
K
D
N
V
P
-
M
Y
V
M
G
V
N
N
T
E
Y
D
P
S
K
F
N
V
I
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
I
I
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
S
L
T
A
N
Q
L
T
V
D
G
P
S
KG-
D
W
R
A
G
R
C
A
G
N
N
I
I
P
A
S
T
G
A
A
K
A
V
G
K
V
I
P
A
L
N
G
K
L
T
G
M
A
I
R
V
P
T
P
D
V
S
V
V
D
L
T
C
K
L
-
A
K
P
-
A
S
I
E
E
I
Y
Q
A
V
K
E
A
S
-------
N
-------
G
P
M
K
G
I
M
G
Y
T
S
D
D
V
V
S
T
D
F
I
G
C
K
Y
S
S
I
F
D
K
N
A
C
I
A
L
N
D
S
F
V
K
L
I
S
W
Y
D
N
E
S
G
Y
S
N
R
L
V
D
L
A
V
Y
V
A
S
R
G
------
103
HHSearch
76.77
54%
2
- C1 -
1RM4
3
G3PA_SPIOL
O:
[1-336]
-
K
L
K
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
--
C
W
H
--
G
--
R
---
K
DS
P
--
L
D
V
V
V
I
N
D
T
-
G
G
V
K
Q
A
S
H
L
L
K
Y
D
S
I
L
G
T
F
D
A
D
-
V
K
T
A
G
D
S
A
I
S
V
D
G
K
V
I
K
V
V
S
D
R
N
P
V
N
L
P
W
G
D
M
G
I
D
L
V
I
E
G
T
G
V
F
V
D
R
D
G
A
G
K
H
L
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
D
I
P
-
T
Y
V
V
G
V
N
E
E
G
Y
T
H
-
A
D
T
I
I
S
N
A
S
C
T
T
N
C
L
A
P
F
V
K
V
L
D
Q
K
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
C
L
N
I
V
P
T
S
T
G
A
A
K
A
V
A
L
V
L
P
N
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
-
S
K
K
-
T
F
A
E
E
V
N
A
A
F
R
E
S
A
-------
D
-------
N
E
L
K
G
I
L
S
V
C
D
E
P
L
V
S
I
D
F
R
C
T
D
V
S
S
T
I
D
S
S
L
T
M
V
M
G
D
D
M
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
A
D
I
V
A
N
K
W
Q
-----
20
PsiBlast_PDB
76.64
54%
-13
- C1 -
3B1J
3
?
A:
[1-335]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
--
C
W
F
G
R
Q
--
N
---
T
--
D
--
L
E
V
V
A
I
N
N
T
-
S
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
N
A
D
-
I
S
Y
D
E
-
N
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
I
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
-
E
K
P
-
T
I
T
E
Q
V
N
E
V
L
Q
K
A
S
-------
Q
-------
T
T
M
K
G
I
I
K
Y
S
D
L
P
L
V
S
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
D
G
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
-
A
E
L
A
A
R
-------
82
PsiBlast_CBE
75.74
54%
-20
- C1 -
3B1K
4
?
B:
[1-335]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
--
C
W
F
GR
Q
--
N
---
T
--
D
--
L
E
V
V
A
I
N
N
T
-
S
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
N
A
D
-
I
S
Y
D
E
-
N
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
I
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
-
E
K
P
-
T
I
T
E
Q
V
N
E
V
L
Q
K
A
S
-------
Q
-------
T
T
M
K
G
I
I
K
Y
S
D
L
P
L
V
S
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
D
G
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
-
A
E
L
A
A
R
-------
83
PsiBlast_CBE
75.12
54%
-18
- C1 -
3B1K
3
?
A:
[1-335]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
--
C
W
F
G
R
Q
--
N
---
T
--
D
--
L
E
V
V
A
I
N
N
T
-
S
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
N
A
D
-
I
S
Y
D
E
-
N
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
I
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
-
E
K
P
-
T
I
T
E
Q
V
N
E
V
L
Q
K
A
S
-------
Q
-------
T
T
M
K
G
I
I
K
Y
S
D
L
P
L
V
S
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
D
G
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
-
A
E
L
A
A
R
-------
116
HHSearch
74.95
51%
4
- C1 -
4BOY
1
?
A:
[17-353]
S
M
V
R
V
A
I
N
G
F
G
R
I
G
R
N
F
M
R
--
C
W
L
--
Q
--
R
KAN
S
--
K
--
L
E
I
V
G
I
N
D
T
-
S
D
P
R
T
N
A
H
L
L
K
Y
D
S
M
L
G
I
F
Q
D
A
E
I
T
A
D
D
-
D
C
I
Y
A
G
G
H
A
V
K
C
V
S
D
R
N
P
E
N
L
P
W
S
A
W
G
I
D
L
V
I
E
A
T
G
V
F
T
S
R
E
G
A
S
K
H
L
S
A
G
A
K
K
V
L
I
T
A
P
G
K
G
N
I
P
-
T
Y
V
V
G
V
N
H
H
T
Y
D
P
-
S
E
D
I
V
S
N
A
S
C
T
T
N
C
L
A
P
I
V
K
V
L
H
E
A
F
G
I
Q
Q
G
M
M
T
T
T
H
S
Y
T
G
D
Q
R
L
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
A
M
N
I
V
P
T
S
T
G
A
A
K
A
V
G
L
V
I
P
E
L
Q
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
F
V
A
Q
V
-
E
K
P
-
T
I
A
E
Q
V
N
Q
V
I
K
E
A
S
-------
E
-------
T
T
M
K
G
I
I
H
Y
S
E
L
E
L
V
S
S
D
Y
R
G
H
N
A
S
S
I
L
D
A
S
L
T
M
V
L
G
G
N
L
V
K
V
V
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
L
D
L
A
E
H
M
A
A
H
W
------
80
PsiBlast_CBE
74.12
54%
-14
- C1 -
3B1K
4
?
H:
[1-335]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
--
C
W
F
GR
Q
--
N
---
T
--
D
--
L
E
V
V
A
I
N
N
T
-
S
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
N
A
D
-
I
S
Y
D
E
-
N
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
I
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
-
E
K
P
-
T
I
T
E
Q
V
N
E
V
L
Q
K
A
S
-------
Q
-------
T
T
M
K
G
I
I
K
Y
S
D
L
P
L
V
S
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
D
G
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
-
A
E
L
A
A
R
-------
119
HHSearch
73.98
45%
-12
- C1 -
3H9E
10
G3PT_HUMAN
O:
[6-341]
R
E
L
T
V
G
I
N
G
F
G
R
I
G
R
L
V
L
R
--
A
C
M
--
E
--
K
------
G
--
V
K
V
V
A
V
N
D
P
F
I
D
P
E
Y
M
V
Y
M
F
K
Y
D
S
T
H
G
R
Y
K
G
S
-
V
E
F
R
N
-
G
Q
L
V
V
D
N
H
E
I
S
V
Y
Q
C
K
E
P
K
Q
I
P
W
R
A
V
G
S
P
Y
V
V
E
S
T
G
V
Y
L
S
I
Q
A
A
S
D
H
I
S
A
G
A
Q
R
V
V
I
S
A
P
S
P
D
-
A
P
-
M
F
V
M
G
V
N
E
N
D
Y
N
P
G
S
M
N
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
H
E
R
F
G
I
V
E
G
L
M
T
T
V
H
S
Y
T
A
T
Q
K
T
V
D
G
P
S
R-
K
A
W
R
D
G
R
G
A
H
Q
N
I
I
P
A
S
T
G
A
A
K
A
V
T
K
V
I
P
E
L
K
G
K
L
T
G
M
A
F
R
V
P
T
P
D
V
S
V
V
D
L
T
C
R
L
-
A
Q
P
-
A
P
Y
S
A
I
K
E
A
V
K
A
A
A
-------
K
-------
G
P
M
A
G
I
L
A
Y
T
E
D
E
V
V
S
T
D
F
L
G
D
T
H
S
S
I
F
D
A
K
A
G
I
A
L
N
D
N
F
V
K
L
I
S
W
Y
D
N
E
Y
G
Y
S
H
R
V
V
D
L
L
R
Y
M
F
S
R
D
A
E
----
66
PsiBlast_CBE
73.91
52%
-14
- C1 -
3L0D
1
?
B:
[22-347]
M
S
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
--
A
I
I
--
E
--
S
---
G
--
R
QD
I
E
V
V
A
L
N
D
L
-
G
S
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
C
F
P
G
T
-
V
Q
V
V
G
-
D
A
I
D
I
---
L
I
K
V
F
A
E
R
D
P
A
Q
L
P
W
K
A
L
D
I
D
I
A
L
E
C
T
G
I
F
T
A
R
D
K
A
S
A
H
L
D
A
G
A
K
R
V
L
V
S
A
P
S
E
G
A
D
L
-
T
V
V
Y
G
V
N
H
-
Q
F
L
S
K
E
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
M
H
--
R
D
L
Y
R
A
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
T
A
-
K
R
S
-
T
T
I
E
E
I
N
T
A
I
R
T
A
A
-------
Q
-------
G
S
L
K
G
I
L
D
Y
T
D
E
K
L
V
S
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
T
K
V
I
D
G
Q
L
C
R
V
L
V
W
Y
D
N
E
W
G
F
S
N
R
M
C
D
---------------
108
HHSearch
73.53
53%
4
- C1 -
1HDG
3
G3P_THEMA
O:
[1-331]
--
A
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
--
I
I
Y
--
E
RK
N
---
P
--
D
--
I
E
V
V
A
I
N
D
L
-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
-
V
E
Y
T
E
-
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
-
T
V
V
I
G
C
N
E
D
Q
L
K
P
-
E
H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
-
E
K
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
-------
E
-------
G
R
L
K
G
I
I
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
--------
17
PsiBlast_PDB
73.26
52%
-12
- C1 -
3L0D
1
?
A:
[22-347]
M
S
V
R
V
A
I
N
G
F
G
R
I
G
R
N
I
L
R
--
A
I
I
--
E
--
S
---
G
--
R
QD
I
E
V
V
A
L
N
D
L
-
G
S
V
E
T
N
A
H
L
L
R
Y
D
S
V
H
G
C
F
P
G
T
-
V
Q
V
V
G
-
D
A
I
D
I
---
L
I
K
V
F
A
E
R
D
P
A
Q
L
P
W
K
A
L
D
I
D
I
A
L
E
C
T
G
I
F
T
A
R
D
K
A
S
A
H
L
D
A
G
A
K
R
V
L
V
S
A
P
S
E
G
A
D
L
-
T
V
V
Y
G
V
N
H
-
Q
F
L
S
K
E
H
H
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
Q
V
L
H
N
T
V
G
I
E
K
G
F
M
T
T
I
H
S
Y
T
G
D
Q
P
V
L
D
T
M
H
--
R
D
L
Y
R
A
R
A
A
A
L
S
M
I
P
T
S
T
G
A
A
K
A
V
G
L
V
L
P
E
L
K
G
L
L
D
G
V
S
I
R
V
P
T
P
N
V
S
V
V
D
L
T
F
T
A
-
K
R
S
-
T
T
I
E
E
I
N
T
A
I
R
T
A
A
-------
Q
-------
G
S
L
K
G
I
L
D
Y
T
D
E
K
L
V
S
C
D
F
N
H
N
P
H
S
A
I
F
H
N
D
Q
T
K
V
I
D
G
Q
L
C
R
V
L
V
W
Y
D
N
E
W
G
F
S
N
R
M
C
D
---------------
84
PsiBlast_CBE
73.16
54%
-9
- C1 -
3B1J
3
?
B:
[1-335]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
--
C
W
F
GR
Q
--
N
---
T
--
D
--
L
E
V
V
A
I
N
N
T
-
S
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
N
A
D
-
I
S
Y
D
E
-
N
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
I
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
-
E
K
P
-
T
I
T
E
Q
V
N
E
V
L
Q
K
A
S
-------
Q
-------
T
T
M
K
G
I
I
K
Y
S
D
L
P
L
V
S
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
D
G
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
-
A
E
L
A
A
R
-------
111
HHSearch
72.70
49%
-0
- C1 -
3PYM
3
G3P3_YEAST
A:
[1-331]
-
M
V
R
V
A
I
N
G
F
G
R
I
G
R
L
V
M
R
--
I
A
L
--
S
--
R
---
P
--
N
--
V
E
V
V
A
L
N
D
P
F
I
T
N
D
Y
A
A
Y
M
F
K
Y
D
S
T
H
G
R
Y
A
G
E
-
V
S
H
D
D
-
K
H
I
I
V
D
G
K
K
I
A
T
Y
Q
E
R
D
P
A
N
L
P
W
G
S
S
N
V
D
I
A
I
D
S
T
G
V
F
K
E
L
D
T
A
Q
K
H
I
D
A
G
A
K
K
V
V
I
T
A
P
S
S
T
-
A
P
-
M
F
V
M
G
V
N
E
E
K
Y
T
S
-
D
L
K
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
I
N
D
A
F
G
I
E
E
G
L
M
T
T
V
H
S
L
T
A
T
Q
K
T
V
D
G
P
S
H-
K
D
W
R
G
G
R
T
A
S
G
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
V
L
P
E
L
Q
G
K
L
T
G
M
A
F
R
V
P
T
V
D
V
S
V
V
D
L
T
V
K
L
-
N
K
E
-
T
T
Y
D
E
I
K
K
V
V
K
A
A
A
-------
E
-------
G
K
L
K
G
V
L
G
Y
T
E
D
A
V
V
S
S
D
F
L
G
D
S
H
S
S
I
F
D
A
S
A
G
I
Q
L
S
P
K
F
V
K
L
V
S
W
Y
D
N
E
Y
G
Y
S
T
R
V
V
D
L
V
E
H
V
A
K
--------
81
PsiBlast_CBE
70.00
54%
-10
- C1 -
3B1K
4
?
G:
[1-335]
M
T
I
R
V
A
I
N
G
F
G
R
I
G
R
N
F
L
R
--
C
W
F
GR
Q
--
N
---
T
--
D
--
L
E
V
V
A
I
N
N
T
-
S
D
A
R
T
A
A
H
L
L
E
Y
D
S
V
L
G
R
F
N
A
D
-
I
S
Y
D
E
-
N
S
I
T
V
N
G
K
T
M
K
I
V
C
D
R
N
P
L
N
L
P
W
K
E
W
D
I
D
L
V
I
E
S
T
G
V
F
V
T
A
E
G
A
S
K
H
I
Q
A
G
A
K
K
V
L
I
T
A
P
G
K
G
E
G
V
G
T
Y
V
I
G
V
N
D
S
E
Y
R
H
E
D
F
A
V
I
S
N
A
S
C
T
T
N
C
L
A
P
V
A
K
V
L
H
D
N
F
G
I
I
K
G
T
M
T
T
T
H
S
Y
T
L
D
Q
R
I
L
D
A
S
H
--
R
D
L
R
R
A
R
A
A
A
V
N
I
V
P
T
T
T
G
A
A
K
A
V
A
L
V
I
P
E
L
K
G
K
L
N
G
I
A
L
R
V
P
T
P
N
V
S
V
V
D
L
V
V
Q
V
-
E
K
P
-
T
I
T
E
Q
V
N
E
V
L
Q
K
A
S
-------
Q
-------
T
T
M
K
G
I
I
K
Y
S
D
L
P
L
V
S
S
D
F
R
G
T
D
E
S
S
I
V
D
S
S
L
T
L
V
M
D
G
D
L
V
K
V
I
A
W
Y
D
N
E
W
G
Y
S
Q
R
V
V
D
L
-
A
E
L
A
A
R
-------
15
PsiBlast_PDB
69.45
53%
11
- C1 -
1HDG
3
G3P_THEMA
O:
[2-326]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
II
Y
E
R
--
K
--
N
---
P
--
D
--
I
E
V
V
A
I
N
D
L
-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
-
V
E
Y
T
E
-
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
-
T
V
V
I
G
C
N
E
D
Q
L
K
P
E
-
H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
-
E
K
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
-------
E
-------
G
R
L
K
G
I
I
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
-------------
62
PsiBlast_CBE
69.39
53%
6
- C1 -
1HDG
3
G3P_THEMA
Q:
[2-326]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
II
Y
E
R
--
K
--
N
---
P
--
D
--
I
E
V
V
A
I
N
D
L
-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
-
V
E
Y
T
E
-
N
S
L
I
V
D
G
K
E
I
K
V
F
A
E
P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
-
T
V
V
I
G
C
N
E
D
Q
L
K
P
E
-
H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
--
K
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
-
E
K
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
-------
E
-------
G
R
L
K
G
I
I
G
Y
N
D
E
P
I
V
S
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
-------------