@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu29050: (2016-07-16 )
MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHGYRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSLSKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAEIKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSVAQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPDNFDF
Atome Classification :
(91 SA)
.........10........20...-----....-.--30.---..-.....40..-......50........60........70-........80........90........100.......110......------------------.--------------------120--------------.---------------.-------.---------------.--------------------....130.......140.......150.......--160--.......170.......180.......190...----.----------..----------.----------200---------.-------.---.......210.......220.......230.......240.......250.......260....-.---..270---.........280
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTT
H
L
Q
A
K
A
TLHNGVEM
P
W
F
G
L
G
V
-----
F
Q
VE-E--
G
S
E
---
L
V
-
N
A
V
K
T
A
I
V
H
-GYRSI
D
T
A
A
I
YGNEAG
V
G
E
G
I
R
E
G
I
E
E
A-GISRE
D
L
F
I
T
S
KVWNADL
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
HWP------------------V--------------------EG---------------
K
---------------
Y
-------
K
---------------
E
--------------------
A
W
R
A
L
E
T
L
Y
KEG
R
I
K
A
I
GVSN
F
Q
I
H
H
L
E
D
L
M
T
A
A
--
E
I
K
--
P
M
I
N
QVEFHPRL
T
Q
K
E
L
I
R
Y
C
Q
NQG
I
Q
MEAWS
P
----
L
----------MQ----------G----------Q-----------L-------L---D
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
RWDLQHG
I
I
TIPKST
K
E
H
RIKENA
S
V
F
D
F
EL
T
Q
D
D
M
N
R
I
D
A
LN-E---NLR-----VGPDPDNFDF
22
PsiBlast_CBE
98.12
100%
-96
- C5 -
3B3D
1
YTBE_BACSU
B:
[38-314]
---
H
L
Q
A
K
A
T
L
H
N
G
V
E
M
P
W
F
G
L
G
V
-----
F
Q
V
E
-
E
--
G
S
E
---
L
V
-
N
A
V
K
T
A
I
V
H
-
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
R
E
G
I
E
E
A
-
G
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
V
--------------------
E
G
---------------
K
---------------
Y
-------
K
---------------
E
--------------------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
T
A
A
--
E
I
K
--
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
----
L
----------
M
Q
----------
G
----------
Q
-----------
L
-------
L
---
D
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
G
I
I
T
I
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
Q
D
D
M
N
R
I
D
A
L
N
-
E
---
N
L
R
-----
V
G
P
D
P
D
N
F
D
F
21
PsiBlast_CBE
97.45
100%
-90
- C5 -
3B3D
1
YTBE_BACSU
C:
[35-314]
M
T
T
H
L
Q
A
K
A
T
L
H
N
G
V
E
M
P
W
F
G
L
G
V
-----
F
Q
V
E
-
E
--
G
S
E
---
L
V
-
N
A
V
K
T
A
I
V
H
-
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
R
E
G
I
E
E
A
-
G
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
V
--------------------
E
G
---------------
K
---------------
Y
-------
K
---------------
E
--------------------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
T
A
A
--
E
I
K
--
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
----
L
----------
M
Q
----------
G
----------
Q
-----------
L
-------
L
---
D
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
G
I
I
T
I
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
Q
D
D
M
N
R
I
D
A
L
N
-
E
---
N
L
R
-----
V
G
P
D
P
D
N
F
D
F
101
HHSearch
96.33
100%
-89
- C5 -
3B3D
1
YTBE_BACSU
A:
[35-314]
M
T
T
H
L
Q
A
K
A
T
L
H
N
G
V
E
M
P
W
F
G
L
G
V
-----
F
Q
V
E
-
E
--
G
S
E
---
L
V
-
N
A
V
K
T
A
I
V
H
-
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
R
E
G
I
E
E
A
-
G
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
V
--------------------
E
G
---------------
K
---------------
Y
-------
K
---------------
E
--------------------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
T
A
A
--
E
I
K
--
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
----
L
----------
M
Q
----------
G
----------
Q
-----------
L
-------
L
---
D
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
G
I
I
T
I
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
Q
D
D
M
N
R
I
D
A
L
N
-
E
---
N
L
R
-----
V
G
P
D
P
D
N
F
D
F
1
PsiBlast_PDB
96.33
100%
-89
- C5 -
3B3D
1
YTBE_BACSU
A:
[35-314]
M
T
T
H
L
Q
A
K
A
T
L
H
N
G
V
E
M
P
W
F
G
L
G
V
-----
F
Q
V
E
-
E
--
G
S
E
---
L
V
-
N
A
V
K
T
A
I
V
H
-
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
R
E
G
I
E
E
A
-
G
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
V
--------------------
E
G
---------------
K
---------------
Y
-------
K
---------------
E
--------------------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
T
A
A
--
E
I
K
--
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
----
L
----------
M
Q
----------
G
----------
Q
-----------
L
-------
L
---
D
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
G
I
I
T
I
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
Q
D
D
M
N
R
I
D
A
L
N
-
E
---
N
L
R
-----
V
G
P
D
P
D
N
F
D
F
104
HHSearch
86.06
72%
-78
- C5 -
3F7J
8
GR_BACSU
A:
[1-276]
M
P
T
S
L
K
D
T
V
K
L
H
N
G
V
E
M
P
W
F
G
L
G
V
-----
F
K
V
E
-
N
--
G
N
E
---
A
T
-
E
S
V
K
A
A
I
K
N
-
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
E
----
S
-
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
D
---------------
K
---------------
Y
-------
K
---------------
D
--------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
--
E
I
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
----
L
----------
M
Q
----------
G
----------
Q
-----------
L
-------
L
---
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
-
K
---
D
E
R
-----
V
G
P
N
P
D
E
L
L
F
2
PsiBlast_PDB
85.85
71%
-78
- C5 -
3F7J
8
GR_BACSU
A:
[1-276]
M
P
T
S
L
K
D
T
V
K
L
H
N
G
V
E
M
P
W
F
G
L
G
V
-----
F
K
V
E
-
N
--
G
N
E
---
A
T
-
E
S
V
K
A
A
I
K
N
-
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
E
----
S
-
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
D
---------------
K
---------------
Y
-------
K
---------------
D
--------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
--
E
I
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
----
L
----------
M
Q
----------
G
----------
Q
-----------
L
-------
L
---
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
-
K
---
D
E
R
-----
V
G
P
N
P
D
E
L
L
F
24
PsiBlast_CBE
85.65
71%
-84
- C5 -
3D3F
1
GR_BACSU
B:
[2-275]
--
T
S
L
K
D
T
V
K
L
H
N
G
V
E
M
P
W
F
G
L
G
V
-----
F
K
V
E
-
N
--
G
N
E
---
A
T
-
E
S
V
K
A
A
I
K
N
-
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
E
----
S
-
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
D
---------------
K
---------------
Y
-------
K
---------------
D
--------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
--
E
I
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
----
L
----------
M
Q
----------
G
----------
Q
-----------
L
-------
L
---
D
N
E
V
L
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Q
I
A
E
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N
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A
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W
D
L
Q
H
G
V
V
T
I
P
K
S
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E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
-
K
---
D
E
R
-----
V
G
P
N
P
D
E
L
L
F
3
PsiBlast_PDB
85.32
71%
-78
- C5 -
3D3F
1
GR_BACSU
A:
[2-275]
--
T
S
L
K
D
T
V
K
L
H
N
G
V
E
M
P
W
F
G
L
G
V
-----
F
K
V
E
-
N
--
G
N
E
---
A
T
-
E
S
V
K
A
A
I
K
N
-
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
E
----
S
-
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
D
---------------
K
---------------
Y
-------
K
---------------
D
--------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
--
E
I
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
----
L
----------
M
Q
----------
G
----------
Q
-----------
L
-------
L
---
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
-
K
---
D
E
R
-----
V
G
P
N
P
D
E
L
L
F
23
PsiBlast_CBE
85.28
71%
-79
- C5 -
3F7J
7
GR_BACSU
B:
[1-276]
M
P
T
S
L
K
D
T
V
K
L
H
N
G
V
E
M
P
W
F
G
L
G
V
-----
F
K
V
E
-
N
--
G
N
E
---
A
T
-
E
S
V
K
A
A
I
K
N
-
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
E
----
S
-
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
D
---------------
K
---------------
Y
-------
K
---------------
D
--------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
--
E
I
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
----
L
----------
M
Q
----------
G
----------
Q
-----------
L
-------
L
---
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
-
K
---
D
E
R
-----
V
G
P
N
P
D
E
L
L
F
27
PsiBlast_CBE
84.39
55%
-92
- C5 -
4FZI
2
PGFS_TRYCC
B:
[17-284]
---------
T
L
H
N
S
V
R
M
P
Q
L
G
L
G
V
-----
W
R
A
Q
-
D
--
G
A
E
---
T
A
-
N
A
V
R
W
A
I
E
A
-
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
E
----
S
-
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
K
---------------
K
---------------
F
-------
V
---------------
D
--------------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
--
K
I
R
--
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
----
L
----------
G
S
---------------------------------
I
-------
L
---
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
-
E
---
D
K
R
-----
I
G
A
D
P
D
N
F
--
102
HHSearch
81.04
51%
-96
- C5 -
1VBJ
2
PGFS_TRYBB
A:
[10-277]
------
Q
S
L
K
L
S
N
G
V
M
M
P
V
L
G
F
G
M
-----
W
K
L
Q
-
D
--
G
N
E
---
A
E
-
T
A
T
M
W
A
I
K
S
-
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
A
S
----
C
-
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
D
---------------
K
---------------
F
-------
I
---------------
D
--------------------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
--
K
V
A
--
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
----
L
----------
G
Q
----------
G
----------
H
-----------
L
-------
V
---
E
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
-
A
---
G
H
R
-----
Y
G
P
D
P
E
V
F
--
8
PsiBlast_PDB
80.48
51%
-96
- C5 -
1VBJ
2
PGFS_TRYBB
A:
[14-277]
----------
L
S
N
G
V
M
M
P
V
L
G
F
G
M
-----
W
K
L
Q
-
D
--
G
N
E
---
A
E
-
T
A
T
M
W
A
I
K
S
-
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
----
A
S
C
-
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
D
---------------
K
---------------
F
-------
I
---------------
D
--------------------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
--
K
V
A
--
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
----
L
----------
G
Q
----------
G
----------
H
-----------
L
-------
V
---
E
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
-
A
---
G
H
R
-----
Y
G
P
D
P
E
V
F
--
28
PsiBlast_CBE
79.72
51%
-92
- C5 -
1VBJ
2
PGFS_TRYBB
B:
[14-277]
----------
L
S
N
G
V
M
M
P
V
L
G
F
G
M
-----
W
K
L
Q
-
D
--
G
N
E
---
A
E
-
T
A
T
M
W
A
I
K
S
-
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
----
A
S
C
-
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
D
---------------
K
---------------
F
-------
I
---------------
D
--------------------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
--
K
V
A
--
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
----
L
----------
G
Q
----------
G
----------
H
-----------
L
-------
V
---
E
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
-
A
---
G
H
R
-----
Y
G
P
D
P
E
V
F
--
105
HHSearch
79.63
56%
-58
- C5 -
4GIE
2
PGFS_TRYCC
A:
[15-284]
-------
C
V
T
L
H
N
S
V
R
M
P
Q
L
G
L
G
V
-----
W
R
A
Q
-
D
--
G
A
E
---
T
A
-
N
A
V
R
W
A
I
E
A
-
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
E
----
S
-
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
K
---------------
K
---------------
F
-------
V
---------------
D
--------------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
--
K
I
R
--
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
----
L
----------
G
S
----------
G
----------
E
-----------
E
-------
A
GIL
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
-
E
---
D
K
R
-----
I
G
A
D
P
D
N
F
--
7
PsiBlast_PDB
79.31
55%
-56
- C5 -
4GIE
2
PGFS_TRYCC
A:
[17-284]
---------
T
L
H
N
S
V
R
M
P
Q
L
G
L
G
V
-----
W
R
A
Q
-
D
--
G
A
E
---
T
A
-
N
A
V
R
W
A
I
E
A
-
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
E
----
S
-
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
K
---------------
K
---------------
F
-------
V
---------------
D
--------------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
--
K
I
R
--
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
----
L
----------
G
S
----------
G
----------
E
EAG--------
I
-------
L
---
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
-
E
---
D
K
R
-----
I
G
A
D
P
D
N
F
--
6
PsiBlast_PDB
78.80
55%
-58
- C5 -
4FZI
1
PGFS_TRYCC
A:
[17-284]
---------
T
L
H
N
S
V
R
M
P
Q
L
G
L
G
V
-----
W
R
A
Q
-
D
--
G
A
E
---
T
A
-
N
A
V
R
W
A
I
E
A
-
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
E
----
S
-
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
K
---------------
K
---------------
F
-------
V
---------------
D
--------------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
--
K
I
R
--
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
----
L
----------
G
S
----------
G
----------
E
EAG--------
I
-------
L
---
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
-
E
---
D
K
R
-----
I
G
A
D
P
D
N
F
--
26
PsiBlast_CBE
73.53
56%
-20
- C5 -
4F40
10
PGFS_LEIMA
B:
[10-288]
-----
K
A
M
V
T
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
-----
W
Q
S
P
-
A
--
G
E
V
---
T
E
-
N
A
V
K
W
A
L
C
A
-
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
----
S
-
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
RGKDILS-----------
K
--------------------
E
G
---------------
K
K--------------
Y
-------
L
---------------
D
--------------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
--
T
V
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
----
L
----------
G
----------------------
K
-----------
L
-------
L
---
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
-
T
---
N
S
R
-----
Y
G
P
D
P
D
E
A
Q
F
25
PsiBlast_CBE
73.50
56%
-11
- C5 -
4G5D
1
PGFS_LEIMA
B:
[10-288]
-----
K
A
M
V
T
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
-----
W
Q
S
P
-
A
--
G
E
V
---
T
E
-
N
A
V
K
W
A
L
C
A
-
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
----
S
-
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
RG
K
D
I
L
S
-----------
K
--------------------
E
G
---------------
K
K--------------
Y
-------
L
---------------
D
--------------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
--
T
V
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
----
L
----------
G
Q
----------
G
----------
K
-----------
L
-------
L
---
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
-
T
---
N
S
R
-----
Y
G
P
D
P
D
E
A
Q
F
115
HHSearch
73.44
47%
-59
- C5 -
4MHB
8
?
A:
[15-273]
-----
M
Q
T
V
K
L
N
N
G
I
A
M
P
L
L
G
F
G
V
-----
F
Q
M
T
-
N
--
T
A
E
---
C
E
-
R
A
V
I
D
A
I
E
T
-
G
Y
R
L
I
D
T
A
A
S
Y
Q
N
E
T
Q
V
G
N
A
L
K
L
----
S
-
G
I
A
R
D
E
L
F
I
T
T
K
L
W
L
Q
D
T
Y
Y
E
G
A
K
A
Q
F
E
R
S
L
N
R
L
Q
L
D
Y
V
D
L
Y
L
I
H
Q
P
------------------
Y
--------------------
G
----------------
D
---------------
V
-------
H
---------------
G
--------------------
A
W
R
A
M
E
E
L
H
Q
A
G
K
I
R
A
I
G
V
S
N
F
H
P
D
R
L
A
D
L
M
A
F
N
--
K
I
I
--
P
A
V
N
Q
I
E
V
N
P
F
N
Q
Q
L
H
A
V
P
W
M
Q
S
R
G
I
Q
P
E
A
W
A
P
----
F
----------
A
E
----------
G
----------
R
NG---------
L
-------
F
---
Q
N
P
V
L
T
A
I
G
E
K
Y
G
K
S
V
G
Q
V
V
L
R
W
I
F
Q
R
G
I
V
S
L
A
K
S
V
R
K
G
R
M
E
E
N
I
N
I
L
D
F
E
L
S
A
E
D
M
L
Q
I
A
A
L
D
-
T
---------------------
4
PsiBlast_PDB
73.39
56%
-20
- C5 -
4F40
11
PGFS_LEIMA
A:
[10-288]
-----
K
A
M
V
T
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
-----
W
Q
S
P
-
A
--
G
E
V
---
T
E
-
N
A
V
K
W
A
L
C
A
-
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
----
S
-
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
RG
K
D
I
L
S
-----------
K
--------------------
E
G
---------------
K
K--------------
Y
-------
L
---------------
D
--------------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
--
T
V
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
----
L
----------
G
----------------------
K
-----------
L
-------
L
---
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
-
T
---
N
S
R
-----
Y
G
P
D
P
D
E
A
Q
F
106
HHSearch
73.34
58%
-22
- C5 -
4F40
11
PGFS_LEIMA
A:
[13-285]
--------
V
T
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
-----
W
Q
S
P
-
A
--
G
E
V
---
T
E
-
N
A
V
K
W
A
L
C
A
-
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
----
S
-
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
------------------
R
--------------------
G
K
D
I
L
S
K
EGK-------
K
---------------
Y
-------
L
---------------
D
--------------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
--
T
V
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
----
L
----------
G
----------------------
K
-----------
L
-------
L
---
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
-
T
---
N
S
R
-----
Y
G
P
D
P
D
E
---
5
PsiBlast_PDB
72.69
56%
-12
- C5 -
4G5D
1
PGFS_LEIMA
A:
[10-288]
-----
K
A
M
V
T
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
-----
W
Q
S
P
-
A
--
G
E
V
---
T
E
-
N
A
V
K
W
A
L
C
A
-
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
----
S
-
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
RG
K
D
I
L
S
-----------
K
--------------------
E
G
---------------
K
K--------------
Y
-------
L
---------------
D
--------------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
--
T
V
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
----
L
----------
G
Q
----------
G
----------
K
-----------
L
-------
L
---
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
-
T
---
N
S
R
-----
Y
G
P
D
P
D
E
A
Q
F
16
PsiBlast_PDB
68.77
41%
-18
- C5 -
3H4G
3
AK1A1_PIG
A:
[8-301]
----------
L
H
T
G
Q
K
M
P
L
I
G
L
G
T
-----
W
K
S
E
-
P
--
G
-
Q
---
V
K
-
A
A
I
K
Y
A
L
T
V
-
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
Q
E
T
V
G
P
G
K
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
A
F
E
RGDNP
F
P
K
N
-----
A
--------------------
D
G
---------------
T
IRYDATH--------
Y
-------
K
---------------
D
--------------------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
--
S
V
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
----
L
----------
G
S
----------
S
----------
D
RAWRDPNEPV-
L
-------
L
---
E
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
-
K
---
N
L
R
---------------
117
HHSearch
68.72
40%
-36
- C5 -
3H7U
2
AKRC9_ARATH
A:
[24-307]
----
A
I
T
F
F
K
L
N
T
G
A
K
F
P
S
V
G
L
G
T
-----
W
Q
A
S
-
P
---
G
L
---
V
G
-
D
A
V
A
A
A
V
K
I
-
G
Y
R
H
I
D
C
A
Q
I
Y
G
N
E
K
E
I
G
A
V
L
K
K
L
F
E
D
R
-
V
V
K
R
E
D
L
F
I
T
S
K
L
W
C
T
D
H
D
P
Q
D
V
P
E
A
L
N
R
T
L
K
D
L
Q
L
E
Y
V
D
L
Y
L
I
H
W
P
------------------
A
--------------------
R
I
K
K
GSVGIKPENLLPV
D
---------------
I
-------
P
---------------
S
--------------------
T
W
K
A
M
E
A
L
Y
D
S
G
K
A
R
A
I
G
V
S
N
F
S
T
K
K
L
A
D
L
L
E
L
A
--
R
V
P
--
P
A
V
N
Q
V
E
C
H
P
S
W
R
Q
T
K
L
Q
E
F
C
K
S
K
G
V
H
L
S
A
Y
S
P
----
L
----------
G
S
----------
P
----------
G
-----------
T
TWLKSDV
L
---
K
N
P
I
L
N
M
V
A
E
K
L
G
K
S
P
A
Q
V
A
L
R
W
G
L
Q
M
G
H
S
V
L
P
K
S
T
N
E
G
R
I
K
E
N
F
N
V
F
D
W
S
I
P
D
Y
M
F
A
K
F
A
E
I
E
-
Q
---------------------
17
PsiBlast_PDB
68.60
41%
-16
- C5 -
3FX4
5
AK1A1_PIG
A:
[8-297]
----------
L
H
T
G
Q
K
M
P
L
I
G
L
G
T
-----
W
K
S
E
-
P
--
G
-
Q
---
V
K
-
A
A
I
K
Y
A
L
T
V
-
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
Q
E
T
V
G
P
G
K
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
A
F
ERGDNP
F
P
K
N
-----
A
--------------------
D
G
---------------
T
I
R
Y
D
ATH--------
Y
-------
K
---------------
D
--------------------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
--
S
V
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
----
L
----------
G
S
----------
S
----------
D
RAWRDPNEPV-
L
-------
L
---
E
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
-
K
---
N
L
R
---------------
54
PsiBlast_CBE
68.25
41%
-34
- C5 -
4GAB
3
AK1BA_HUMAN
A:
[7-297]
----------
L
S
T
K
A
K
M
P
I
V
G
L
G
T
-----
W
K
S
P
-
L
--
G
-
K
---
V
K
-
E
A
V
K
V
A
I
D
A
-
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
E
K
I
Q
E
K
-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
KSGDDL
F
P
K
D
DKG
N
A
I
--------------------
G
G
---------------
K
AT-------------
F
-------
L
---------------
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL
K
Y
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
----
L
----------
G
S
----------
P
DRPWAKPEDP
S
-----------
L
-------
L
---
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
L
S
F
N
-
R
---
N
W
R
---------------
55
PsiBlast_CBE
68.19
41%
-36
- C5 -
4GA8
2
AK1BA_HUMAN
A:
[7-297]
----------
L
S
T
K
A
K
M
P
I
V
G
L
G
T
-----
W
K
S
P
-
L
--
G
-
K
---
V
K
-
E
A
V
K
V
A
I
D
A
-
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
E
K
I
Q
E
K
-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
KSGDDL
F
P
K
D
DKG
N
A
I
--------------------
G
G
---------------
K
AT-------------
F
-------
L
---------------
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S