@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu29100: (2016-07-16 )
MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIEKEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKVQALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLCTAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSLAIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLRRLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGIVLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLSIILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISLHLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSGIGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTVFTVTLKRAAEKSA
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.....-..230-.........240.......250.......260.......270-----..-----.....280.......290......---.300.......310.......320.......330-........340.......------350-------..---------.......360.......370.......380-.......390.......400.......410.......420..----.....430---........440...-..-----..450--...-....460.......470.......480.....---.---.490...--....-500.......510.......520.......530.......540.......-550.......560.......570--.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNK
Y
R
V
R
L
F
S
V
F
V
V
C
M
I
L
V
F
C
V
L
G
L
F
L
Q
Q
L
F
ETS
D
Q
R
K
A
E
E
H
I
E
K
E
A
K
Y
L
A
S
L
L
DAGNLN
N
Q
A
N
E
K
I
I
K
DAGG
A
L
D
V
S
A
S
V
IDTDG
K
V
L
YGSNGRS
A
D
S
Q
K
V
Q
A
L
V
SGHEG
I
L
STTDN
K
L
Y
Y
G
L
S
LRSEGEKT
G
Y
V
L
L
SASEKSDGL
K
G
E
L
W
G
M
L
T
A
S
L
C
T
A
F
I
V
I
V
Y
F
Y
S
S
M
T
S
R
Y
K
R
S
I
E
S
A
T
N
V
A
T
E
L
SKGNYDARTYG
G
Y
I
RRS
D
K
L
G
H
A
M
N
S
L
A
I
D
L
M
E
M
T
R
-
T
Q
E
---
M
Q
R
D
R
L
L
T
V
I
E
N
IGS
G
L
I
M
IDG
R
G
F
I
N
L
V
N
R
S
Y
A
KQFHI
N
P
N
-----
H
M
-----
L
R
R
L
Y
H
D
AF
E
H
E
E
V
I
Q
L
V
E
D
I
F
MT---ETK
K
C
K
L
L
RL
P
I
K
I
E
R
R
Y
F
EVDGVPIMGPDDE-W-
K
G
I
V
L
V
FHDM
T
E
T
K
K
L
E
Q
------
M
---------
R
K
---------
D
F
V
A
N
V
S
H
E
LKT
P
I
T
S
I
K
G
F
T
E
T
L
L
DGAME-
D
K
E
A
L
S
E
F
L
S
I
I
L
K
E
S
E
R
L
Q
S
L
V
Q
D
L
L
D
L
S
K
I
EQQ
N
F
T
L
S
I
E----TF
E
P
A
K
M
----
L
G
E
I
E
T
L
L
K
HKADE-KG-----
I
S
L
H
L
--NVP-KDPQYVSG
D
P
Y
R
L
K
Q
V
F
L
N
L
VNN
A
L
T
YTPEG
G
---
S
---
V
A
I
N
V
KP--REK
D
-
I
Q
I
E
VADSGIGI
Q
K
E
E
I
P
R
I
F
E
R
F
Y
RVDKDRSRNSGGT
G
L
G
L
A
I
V
K
H
L
I
E
-AHEG
K
I
D
V
T
S
ELGRG
T
V
F
T
V
T
L
K
--
R
AAEKSA
57
HHSearch
71.70
28%
-33
- C2 -
4I5S
-
?
A:
[37-432]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
-
N
L
A
---
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
-----
Q
A
-----
L
E
C
N
I
L
D
I
L
D
D
D
S
Y
T
--
Y
N
D
L
I
T
K
---
T
-
P
E
I
V
L
T
R
R
D
E
Y
D
E
F
I
T
L
R
I
R
F
A
L
N
R
R
E
S
G
F
-
I
-
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
R
------
E
---------
R
R
---------
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
A
L
T
--
E
S
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
-----
S
H
L
D
V
E
----
L
T
N
F
T
A
F
----
M
N
Y
I
L
D
R
F
D
Q
I
Q
S
Q
-
Q
S
T-----
E
I
I
R
--
D
Y
P
-
D
K
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
G
---
K
---
V
T
I
T
M
Q
T
--
T
D
T
Q
-
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
---------
16
PsiBlast_PDB
67.16
28%
6
- C2 -
3A0R
1
?
A:
[12-348]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
L
E
S
L
E
T
A
I
I
T
L
S
K
D
G
R
I
T
E
W
N
K
K
A
E
Q
L
F
G
L
K
K
E
-----
N
V
-----
L
G
R
R
L
K
D
L
P
D
F
E
E
I
G
S
V
A
E
S
V
F
-----
E
N
K
E
P
V
F
L
N
F
-
Y
K
F
G
E
R
Y
F
N
I
R
F
S
P
F
R
N
A
K
T
Q
-
L
L
E
G
V
I
I
T
I
D
D
V
T
E
L
Y
K
Y
E
E
------
E
---------
R
K
R
R
E
R
L
S
I
L
G
E
M
T
A
R
V
A
H
E
I
R
N
P
I
T
I
I
G
G
F
I
-
M
R
M
K
K
H
L
D
-
D
P
E
T
L
K
K
Y
I
N
I
I
T
N
E
L
S
R
L
E
T
I
V
K
E
I
L
E
Y
S
K
E
R
----
V
L
E
F
T
----
E
F
N
L
N
E
L
----
I
R
E
V
Y
V
L
F
E
E
K
I
R
K
-
M
N
-----
I
D
F
C
F
--
E
T
D
-
N
E
D
L
R
V
E
A
D
R
T
R
I
K
Q
V
L
I
N
L
V
Q
N
A
I
E
A
T
G
E
N
G
---
K
---
I
K
I
T
S
E
D
--
M
Y
T
K
-
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
K
E
K
I
F
S
P
F
F
------
T
T
------
L
G
L
S
I
C
R
K
I
I
E
D
E
H
G
G
K
I
-
W
T
E
N
R
E
N
G
V
V
F
I
F
E
I
P
--
K
T
P
E
K
--
1
PsiBlast_PDB
66.30
100%
-79
* C4 *
3CWF
2
PHOR_BACSU
A:
[5-113]
--------------------------------
T
S
D
Q
R
K
A
E
E
H
I
E
K
E
A
K
Y
L
A
S
L
L
D
A
G
N
L
N
N
Q
A
N
E
K
I
I
K
D
A
G
G
A
L
D
V
S
A
S
V
I
D
T
D
G
K
V
L
Y
G
S
N
G
R
S
A
D
S
Q
K
V
Q
A
L
V
S
G
H
E
G
I
L
S
-
T
D
N
K
L
Y
Y
G
L
S
L
R
S
E
G
E
K
T
G
Y
V
L
L
S
A
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
HHSearch
66.09
33%
-86
- C2 -
4Q20
-
DIVL_CAUCR
A:
[535-758]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
A
E
R
------
L
---------
K
R
---------
D
F
V
G
N
V
S
Y
E
L
R
T
P
L
T
T
I
I
G
Y
S
E
L
L
E
R
A
D
----
S
E
R
G
R
N
H
V
A
A
V
R
A
A
A
T
Q
L
A
R
S
I
D
D
V
L
D
M
A
Q
I
D
A
G
E
M
A
L
E
I
E
----
D
I
R
V
S
D
L
----
L
L
N
A
Q
E
R
A
L
K
D
A
Q
L
-
G
G
-----
V
T
L
A
V
--
E
C
E
-
E
D
V
G
L
I
R
G
D
G
K
R
L
A
Q
T
L
D
H
L
V
E
N
A
L
R
Q
T
P
P
G
G
---
R
---
V
T
L
S
A
R
R
--
A
L
G
E
-
V
R
L
D
V
S
D
T
G
R
G
V
P
F
H
V
Q
A
H
I
F
D
R
F
V
G
R
D
------
R
G
G
P
G
L
G
L
A
L
V
K
A
L
V
E
-
L
H
G
G
W
V
A
L
E
S
E
P
G
N
G
S
T
F
T
C
H
L
P
--
E
T
Q
----
48
Fugue
65.90
30%
34
- C2 -
4I5S
-
?
A:
[37-432]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
L
K
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
-
N
L
A
---
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
-----
Q
A
LECNI
L
D
I
L
D
D
D
S
Y
T
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
RRD
E
Y
D
E
F
I
T
L
R
I
R
F
A
L
N
R
R
-----------
E
S
G
F
-
I
-
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
R
------
E
---------
R
R
---------
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
A
L
T
-
E
-
S
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
S
H
-----
L
D
V
E
----
L
T
N
F
T
A
F
----
M
N
Y
I
L
D
R
F
D
Q
I
Q
S
Q
-
Q
S
-----
T
E
I
I
R
--
D
Y
P
-
D
K
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
G
---
K
---
V
T
I
T
M
Q
T
--
T
D
T
Q
-
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
---------
55
Fugue
64.65
98%
-73
- C4 -
3CWF
2
PHOR_BACSU
A:
[5-113]
--------------------------------
T
S
D
Q
R
K
A
E
E
H
I
E
K
E
A
K
Y
L
A
S
L
L
D
A
G
N
L
N
N
Q
A
N
E
K
I
I
K
D
A
G
G
A
L
D
V
S
A
S
V
I
D
T
D
G
K
V
L
Y
G
S
N
G
R
S
A
D
S
Q
K
V
Q
A
L
V
S
G
H
E
G
I
-
L
S
T
D
N
K
L
Y
Y
G
L
S
L
R
S
E
G
E
K
T
G
Y
V
L
L
S
A
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
63.88
36%
18
- C2 -
4U7O
1
?
A:
[25-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
D
N
------
D
---------
R
K
---------
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
----
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
D
N
P
A
K
Y
-----
Y
T
I
K
R
--
E
F
T
-
K
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
---
V
---
V
T
C
R
L
L
E
--
T
H
N
Q
-
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
----------
61
HHSearch
62.70
34%
25
- C2 -
4U7O
1
?
A:
[25-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
Q
Q
K
I
D
N
------
D
---------
R
K
---------
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
----
L
V
N
I
N
E
M
----
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
-
D
D
NPA
K
Y
Y
T
I
K
R
--
E
F
T
-
K
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
---
V
---
V
T
C
R
L
L
E
--
T
H
N
Q
-
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-----
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
--
Y
E
-----
58
HHSearch
62.61
28%
7
- C2 -
3A0R
1
?
A:
[9-347]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
E
S
I
L
E
S
L
E
T
A
I
I
T
L
S
K
D
G
R
I
T
E
W
N
K
K
A
E
Q
L
F
G
L
K
K
E
-----
N
V
-----
L
G
R
R
L
K
D
L
P
D
F
E
E
I
G
S
V
A
E
S
V
F
E
N
---
K
E
P
---
V
F
L
N
F
Y
K
F
G
E
R
Y
F
N
I
R
F
S
P
F
R
N
A
K
T
Q
L
L
-
E
G
V
I
I
T
I
D
D
V
T
E
L
Y
K
Y
E
E
------
E
R
K
R
R
E
R
L
S
I
L
G
---------
E
M
T
A
R
V
A
H
E
I
R
N
P
I
T
I
I
G
G
F
I
M
R
M
K
K
H
L
D
D
--
P
E
T
L
K
K
Y
I
N
I
I
T
N
E
L
S
R
L
E
T
I
V
K
E
I
L
E
Y
S
K
E
R
----
V
L
E
F
T
----
E
F
N
L
N
E
L
----
I
R
E
V
Y
V
L
F
E
E
K
I
R
K
-
M
N
-----
I
D
F
C
F
--
E
T
D
-
N
E
D
L
R
V
E
A
D
R
T
R
I
K
Q
V
L
I
N
L
V
Q
N
A
I
E
A
T
G
E
N
G
---
K
---
I
K
I
T
S
E
D
--
M
Y
T
K
-
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
K
E
K
I
F
S
P
F
F
T
T
------------
L
G
L
S
I
C
R
K
I
I
E
D
E
H
G
G
K
I
W
T
E
N
R
-
E
N
G
V
V
F
I
F
E
I
P
--
K
T
P
E
---
3
PsiBlast_PDB
62.61
36%
-27
- C2 -
4U7N
-
?
A:
[386-607]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
R
V
D
M
E
----
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
D
N
---
Y
-----
Y
T
I
K
R
--
E
F
T
-
K
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
---
V
---
V
T
C
R
L
L
E
--
T
H
N
Q
-
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
-----------
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
----------
22
PsiBlast_CBE
60.98
37%
46
- C2 -
4JAV
6
?
B:
[5-248]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
S
K
E
L
E
R
L
K
R
I
D
R
M
---------
K
T
---------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
----
K
V
D
L
C
D
L
----
V
E
S
A
V
N
A
I
K
E
F
A
S
S
-
H
N
-----
V
N
V
L
F
E
S
N
V
P
-
C
-
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
D
K
Y
V
K
V
I
L
D
E
--
K
D
G
G
-
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D-------
60
HHSearch
60.84
30%
-96
- C2 -
4BIX
3
CPXA_ECOLI
A:
[61-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
G
A
S
F
N
Q
V
V
T
A
L
E
R
M
M
T
---------------------------------------------------------------------------------------------------------------------------------------------------
S
---------
Q
Q
---------
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
------
E
S
K
E
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
-
A
L
V
S
E
----
T
I
K
A
N
Q
L
----
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
-
M
G
-----
K
S
L
T
V
--
N
F
P
-
P
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
--------
I
E
V
G
F
A
V
--
D
K
D
G
-
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
--------
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
--
L
Y
K
R
---
7
PsiBlast_PDB
60.63
37%
51
- C2 -
4JAV
6
?
A:
[3-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
T
E
S
K
E
L
E
R
L
K
R
I
D
R
M
---------
K
T
---------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
----
K
V
D
L
C
D
L
----
V
E
S
A
V
N
A
I
K
E
F
A
S
S
-
H
N
-----
V
N
V
L
F
E
S
N
V
P
-
C
-
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
D
K
Y
V
K
V
I
L
D
E
--
K
D
G
G
-
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D-------
2
PsiBlast_PDB
60.52
33%
32
- C2 -
4I5S
-
?
A:
[77-432]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
R
S
G
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
QALEC
N
I
-----
L
D
I
L
D
D
D
S
Y
T
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
RRD
E
Y
D
E
F
I
T
L
R
I
R
F
A
L
N
R
R
--
E
S
G
F
I
-----------
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
R
------
E
---------
R
R
---------
L
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
A
L
T
-
E
S
V
A
P
S
-
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
-----
S
H
L
D
V
E
L
T
N
F
T
A
F
M
N
Y
I
----
L
D
R
F
D
Q
I
Q
S
Q
Q
S
T
----------
E
I
I
R
--
D
Y
P
-
D
K
S
V
W
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
P
D
G
G
---
K
---
V
T
I
T
M
Q
T
--
T
D
T
Q
-
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
A
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
---------
23
PsiBlast_CBE
60.42
37%
31
- C2 -
3DGE
2
?
B:
[14-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRIDR-
M
---------
K
T
---------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
----
K
V
D
L
C
D
L
----
V
E
S
A
V
N
A
I
K
E
F
A
S
S
-
H
N
-----
V
N
V
L
F
ES
N
V
P
-
C
-
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
DKY
V
K
V
I
L
D
E
--
K
D
G
G
-
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
KD
R
A
-----
6
PsiBlast_PDB
59.94
37%
26
- C2 -
3DGE
3
?
A:
[14-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KR
I
D
R
-
M
---------
K
T
---------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
----
K
V
D
L
C
D
L
----
V
E
S
A
V
N
A
I
K
E
F
A
S
S
-
H
N
-----
V
N
V
L
F
E
S
N
V
P
-
C
-
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
D
K
Y
V
K
V
I
L
D
E
--
K
D
G
G
-
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
KD
R
A
-----
5
PsiBlast_PDB
58.34
37%
36
- C2 -
2C2A
2
?
A:
[3-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
T
E
S
K
E
L
E
R
L
K
R
I
D
R
M
---------
K
T
---------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
----
K
V
D
L
C
D
L
----
V
E
S
A
V
N
A
I
K
E
F
A
S
S
-
H
N
-----
V
N
V
L
F
E
S
N
V
P
-
C
-
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
D
K
Y
V
K
V
I
L
D
E
--
K
D
G
G
-
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
---------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
KD
R
A
-----
8
PsiBlast_PDB
57.89
37%
38
- C2 -
4JAS
2
?
A:
[13-249]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LKR
I
D
R
M
---------
K
T
---------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
----
K
V
D
L
C
D
L
----
V
E
S
A
V
N
A
I
K
E
F
A
S
S
-
H
N
-----
V
N
V
L
F
E
S
N
V
P
-
C
-
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
D
K
Y
V
K
V
I
L
D
E
--
K
D
G
G
-
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
S
L
T
Y
E
V
P
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
R
------
9
PsiBlast_PDB
57.36
37%
31
- C2 -
4JAU
1
?
A:
[7-247]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
L
E
R
L
K
R
I
D
R
M
---------
K
T
---------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
----
K
V
D
L
C
D
L
----
V
E
S
A
V
N
A
I
K
E
F
A
S
S
-
H
N
-----
V
N
V
L
F
E
S
N
V
P
-
C
-
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
---
P
D
K
Y
V
K
V
I
L
D
E
--
K
D
G
G
-
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
---------
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K--------
21
PsiBlast_CBE
55.58
36%
30
- C2 -
4U7O
1
?
B:
[37-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
A
W
K
-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
------
T
R
V
D
M
E
----
L
V
N
I
N
E
M
F
N
Y
V
L
D
R
F
D
M
I
L
K
K
D
D
N
P
A
K
Y
-----
Y
T
I
K
R
--
E
F
T
-
K
R
D
L
W
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
P
D
G
G
---
V
---
V
T
C
R
L
L
E
--
T
H
N
Q
-
V
I
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
A
R
---
Q
G
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
----------
78
HHSearch
54.51
40%
-55
* C2 *
3SL2
2
A:
[3-153]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
I
V
R
F
----
M
S
L
I
I
D
R
F
E
M
T
K
-
E
-
Q
-------
E
F
I
R
--
N
L
P
-
D
R
D
L
Y
V
E
I
D
Q
D
K
I
T
Q
V
L
D
N
I
I
S
N
A
L
K
Y
S
P
E
G
G
---
H
---
V
T
F
S
I
D
V
NE
E
E
E
L
-
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
V
E
K
V
F
D
R
F
Y
R
V
D
------
L
G
G
T
G
L
G
L
A
I
A
K
E
M
V
Q
-
A
H
G
G
D
I
W
A
D
S
I
E
G
K
G
T
T
I
T
F
T
L
P
--
Y
K
E
----
29
PsiBlast_CBE
54.28
36%
-35
- C2 -
4BIY
3
CPXA_ECOLI
C:
[70-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
T
------
S
---------
Q
Q
---------
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
-
E
----
T
I
K
A
N
Q
L
----
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
-
M
G
-----
K
S
L
T
V
--
N
F
P
-
P
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
---
V
G
F
A
V
-----
D
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
---------
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
--------------------------
67
HHSearch
54.00
36%
62
- C2 -
2C2A
2
?
A:
[18-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
------
M
---------
K
T
---------
E
F
I
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
Q
I
N
R
E
----
K
V
D
L
C
D
L
----
V
E
S
A
V
N
A
I
K
E
F
A
S
S
-
H
N
-----
V
N
V
L
F
--
E
S
N
V
P
C
P
V
E
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
A
P
D
K
Y
---
V
K
V
I
L
D
E
--
K
D
G
G
-
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
---------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
--
K
D
R
A
---
13
PsiBlast_PDB
53.29
36%
-34
- C2 -
4BIX
3
CPXA_ECOLI
A:
[70-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
T
------
S
---------
Q
Q
---------
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
-
E
----
T
I
K
A
N
Q
L
----
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
-
M
G
-----
K
S
L
T
V
--
N
F
P
-
P
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
---
V
G
F
A
V
-----
D
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
--------
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
--------------------------
14
PsiBlast_PDB
53.01
36%
-39
- C2 -
4BIY
3
CPXA_ECOLI
A:
[70-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
A
L
E
R
M
M
T
------
S
---------
Q
Q
---------
R
L
L
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
R
S
G
E
-
S
K
E
-----
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
N
Q
Q
K
N
A
L
V
S
-
E
----
T
I
K
A
N
Q
L
----
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
-
M
G
-----
K
S
L
T
V
--
N
F
P
-
P
G
P
W
P
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
H
T
K
I
---
E
---
V
G
F
A
V
-----
D
K
D
G
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
---------
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
--------------------------