@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu29340: (2016-07-17 )
MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFLRCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVMEGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDVLLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIVEQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI
Atome Classification :
(33 SA)
.........10.----.......20........30........40........50........60......--------..70........80......--..90........100..---.....110.........120.......130.-..-....140.......150.......160.......170.......180...-.-...190.......200.......210.......220.......230.......240.......250.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MI
E
I
K
N
I
H
K
Q
F
G
----
I
H
H
V
L
KG
I
N
L
T
V
RKG
E
V
V
T
I
IGPSGS
G
K
T
T
F
L
R
C
L
N
L
LERPDEG
I
I
S
I
HD
K
V
I
N
C
--------RFPSK
K
E
V
H
W
L
R
K
Q
T
A
M
V
F
Q
--
Q
Y
H
L
F
A
H
K
T
V
I
E
N
V
M
E
G
---
L
T
I
A
R
K
--
M
R
K
Q
D
A
Y
A
V
A
E
N
E
L
R
KVG
L
Q
D
K
L
-
N
A-Y
P
S
QLSGGQ
K
Q
RV
G
I
A
R
A
LAIHP
D
V
L
L
FDEPTAAL
D
P
E
L
V
G
E
V
L
E
V
M
L
E
I
-
V
-KTG
A
T
M
I
V
V
TH
E
M
E
F
A
R
R
VSD
Q
V
V
F
MDE
G
V
I
VEQG
T
P
E
E
V
F
R
H
T
K
K
D
R
T
R
Q
F
L
R
RV
S
P
E
YLF
E
P
K
E
H
I
KEPVI
21
PsiBlast_CBE
94.76
54%
-126
- C1 -
4YMV
1
?
A:
[1-239]
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
-----------
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
---
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
-
D
Q
-
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-----------------
2
PsiBlast_PDB
94.26
54%
-125
- C1 -
4YMT
-
?
J:
[1-239]
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
-----------
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
---
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
-
D
Q
-
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-----------------
24
PsiBlast_CBE
93.69
53%
-130
- C1 -
3C4J
4
?
B:
[24-262]
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
--------
K
-
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
22
PsiBlast_CBE
93.64
54%
-130
- C1 -
4YMU
2
?
A:
[1-239]
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
-----------
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
---
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
-
D
Q
-
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-----------------
4
PsiBlast_PDB
93.19
54%
-126
- C1 -
4YMV
1
?
J:
[1-239]
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
-----------
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
---
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
-
D
Q
-
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-----------------
3
PsiBlast_PDB
92.48
54%
-126
- C1 -
4YMU
2
?
J:
[1-239]
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
-----------
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
---
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
-
D
Q
-
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-----------------
1
PsiBlast_PDB
92.40
54%
-126
- C1 -
4YMS
-
?
J:
[1-239]
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
-----------
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
---
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
-
D
Q
-
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-----------------
5
PsiBlast_PDB
91.67
54%
-124
- C1 -
4YMW
-
?
J:
[1-239]
M
I
F
V
N
D
V
Y
K
N
F
G
----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
N
N
-----------
G
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
---
P
V
K
V
K
K
--
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
K
K
-
D
Q
-
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-----------------
28
PsiBlast_CBE
91.59
53%
-131
- C1 -
2OUK
2
?
B:
[24-262]
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
--------
K
-
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
27
PsiBlast_CBE
90.58
53%
-128
- C1 -
2OUK
1
?
C:
[24-262]
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
--------
K
-
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
7
PsiBlast_PDB
90.52
53%
-137
- C1 -
2OLJ
4
?
A:
[24-262]
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
--------
K
-
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
12
PsiBlast_PDB
90.35
52%
-119
- C1 -
4U00
3
?
A:
[4-241]
I
I
R
I
R
N
L
H
K
W
F
G
----
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
------------
D
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
--
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
---
P
M
R
V
R
R
--
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
-
R
K
-
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
-----------------
9
PsiBlast_PDB
90.34
53%
-134
- C1 -
2OUK
1
?
A:
[24-262]
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
--------
K
-
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
30
PsiBlast_CBE
90.23
53%
-132
- C1 -
2OLK
1
?
C:
[24-262]
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
--------
K
-
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
8
PsiBlast_PDB
89.81
53%
-133
- C1 -
2OLK
1
?
A:
[24-262]
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
--------
K
-
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
135
HHSearch
89.41
53%
-120
- C1 -
4U00
3
?
A:
[4-240]
I
I
R
I
R
N
L
H
K
W
F
G
----
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
D
--------
D
----
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
--
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
---
P
M
R
V
R
R
--
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
-
R
K
-
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
------------------
23
PsiBlast_CBE
89.23
53%
-129
- C1 -
3C41
3
?
K:
[3-241]
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
--------
K
-
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
13
PsiBlast_PDB
88.99
52%
-118
- C1 -
4U02
1
?
A:
[4-241]
I
I
R
I
R
N
L
H
K
W
F
G
----
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
K
------------
D
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
--
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
---
P
M
R
V
R
R
--
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
-
R
K
-
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
-
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
-----------------
26
PsiBlast_CBE
88.88
53%
-128
- C1 -
2OUK
2
?
D:
[24-262]
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
--------
K
-
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
6
PsiBlast_PDB
88.74
53%
-121
- C1 -
3C41
3
?
J:
[3-241]
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
--------
K
-
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
10
PsiBlast_PDB
88.07
53%
-127
- C1 -
2Q0H
4
?
A:
[24-262]
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
--------
K
-
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
29
PsiBlast_CBE
87.97
53%
-126
- C1 -
2OLK
1
?
D:
[24-262]
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
--------
K
-
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
25
PsiBlast_CBE
87.84
53%
-132
- C1 -
2Q0H
4
?
B:
[24-262]
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
--------
K
-
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
11
PsiBlast_PDB
87.00
53%
-125
- C1 -
3C4J
3
?
A:
[24-262]
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
--------
K
-
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
31
PsiBlast_CBE
86.91
53%
-126
- C1 -
2OLK
2
?
B:
[24-262]
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
--------
K
-
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
32
PsiBlast_CBE
85.94
53%
-123
- C1 -
2OLJ
3
?
B:
[24-262]
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
--
I
N
L
--------
K
-
A
K
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
---
P
M
K
V
R
K
--
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
14
PsiBlast_PDB
78.56
50%
-26
- C1 -
1B0U
4
HISP_SALTY
A:
[7-254]
-
L
H
V
I
D
L
H
K
R
Y
G
----
G
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
KDGQL
K
V
A
D
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
--
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
E
A
---
P
I
Q
V
L
G
--
L
S
K
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
-
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
-
A
-
E
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
-------------------
79
PsiBlast_CBE
47.91
39%
-10
- C1 -
4MKI
4
ECFA2_CALS4
A:
[27-241]
--------------------
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
D
--------
K
K
V
S
L
K
D
I
---
R
K
Q
V
G
L
V
F
Q
YP
E
Y
Q
L
F
-
E
E
T
V
F
K
D
I
A
F
G
P
S
N
L
G
L
S
E
E
--
E
V
K
E
R
V
Y
E
A
M
E
----
I
V
G
I
S
K
E
L
A
D
K
-
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
-
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
A
E
R
---------------------------
78
PsiBlast_CBE
47.74
39%
-16
- C1 -
4MKI
4
ECFA2_CALS4
B:
[27-241]
--------------------
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
D
I
T
D
--------
K
K
V
S
L
K
D
I
---
R
K
Q
V
G
L
V
F
Q
YP
E
Y
Q
L
F
-
E
E
T
V
F
K
D
I
A
F
G
P
S
N
L
G
L
S
E
E
--
E
V
K
E
R
V
Y
E
A
M
E
----
I
V
G
I
S
K
E
L
A
D
K
-
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
-
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
A
E
R
---------------------------
76
PsiBlast_CBE
44.78
34%
14
- C1 -
3TIF
7
Y796_METJA
B:
[1-221]
M
V
K
L
K
N
V
T
K
T
Y
K
MGEE
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
-
D
N
I
K
T
N
--------
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
---
L
I
F
K
Y
R
GA
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
-
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
-
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
--------------------------------------------
72
PsiBlast_CBE
44.31
34%
13
- C1 -
1L2T
4
Y796_METJA
B:
[1-221]
M
I
K
L
K
N
V
T
K
T
Y
K
MGEE
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
-
D
N
I
K
T
N
--------
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
---
L
I
F
K
Y
R
GA
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
-
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
-
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
--------------------------------------------
77
PsiBlast_CBE
42.88
34%
17
- C1 -
3TIF
7
Y796_METJA
A:
[1-221]
M
V
K
L
K
N
V
T
K
T
Y
K
M
GE
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
-
D
N
I
K
T
N
--------
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
---
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
-
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
-
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
--------------------------------------------
73
PsiBlast_CBE
42.34
34%
13
- C1 -
1L2T
4
Y796_METJA
A:
[1-221]
M
I
K
L
K
N
V
T
K
T
Y
K
M
GE
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
-
D
N
I
K
T
N
--------
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
---
L
I
F
K
Y
R
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
-
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
-
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
--------------------------------------------