@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu29560: (2016-07-17 )
MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWSYEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLRAKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGSQFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWATAAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMAKVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDTPIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQIRGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVASPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTASAKIRRVELRKREEQLKANKKA
Atome Classification :
(23 SA)
.........10.......-------.20...--.....30...-...-..40........50........60-........70........80........90........100.......110.......120..-..--...---------------130---------.--.---.----...--.140.-...-.-----------..150.-.------....-----.160..----......170.......180.......190.......200.......210.......220.......230.......240..-.-..---..---250.......260.......270.-......-280-........290.......300.......310--.---.......320..-----.....330..--.....340.......350.......360.......370--.---..---.....380.......390---....---...400.......410.......420.......430.......440.......450.......460.......470..--.....480.......490.......500.......510.......520.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLKREDLIA
P
V
Q
Y
N
L
V
N
E
-------
M
E
K
F
SA--AGQ
K
T
A
L
L
WE-DES-GKQESW
S
Y
E
K
L
M
E
E
T
N
K
I
G
A
A
L
A
D
-LGFKKG
D
K
L
I
V
M
V
P
R
V
L
E
A
Y
A
V
Y
L
A
I
L
KS
G
M
V
V
I
P
C
S
E
M
L
R
A
K
D
L
E
Y
R
I
EHAEVK
G
A
I
V
Y
S
E
F
-
I
G
--
A
FR---------------DVS---------T--A---
D
----
K
L
I
--
T
L
S
IG-END-A-----------G
W
K
N
L
L
-
S
------
I
EAD-----GSQ-FK----TADTTRD
D
M
A
F
L
S
YTSGTTGQPK
G
V
V
HTH
G
W
A
F
A
H
L
KTSAG
A
W
L
DISEK
D
I
V
W
A
TAAPG
W
Q
K
W
V
W
S
P
F
L
A
V
LGSGA
T
G
F
V
Y-H-GR---F
K
---
A
E
K
Y
L
E
L
L
N
RY
K
I
N
V
F
C
CTPT
E
Y
R
-
L
M
A
K
V
E
-
G
L
--
K
RF
D
L
S
A
L
H
S
A
V
SAGEPL
N
R
E
V
I
D
V
F
Q
K
HF---
G
---
I
K
V
RDGYGQTE
S
-----
T
L
L
V
G
V
LKDT--PIKPGSMGKPTPG
N
Q
V
E
I
INEDGEICKPGEV
G
D
I
A
V
H---L---S
T
---
P
A
L
F
K
E
Y
FK
D
P
E
R
M
K
T
Q
I---RG
D
Y
---
F
LTGDRARKDEE
G
Y
F
W
F
ESRND
D
I
I
ISSG
Y
T
I
G
P
F
E
V
E
D
A
L
VKHPEVK
E
C
A
V
VA
S
P
D
E
I
R
G
S
I
V
K
A
Y
V
V
LQNHEK
R
S
D
--
E
L
V
K
M
L
Q
N
H
V
K
T
ITAPYKYP
R
E
I
E
F
V
E
SLP
K
T
A
SAK
I
R
R
V
E
L
R
K
R
E
E
Q
LKANKKA
11
PsiBlast_PDB
90.26
30%
0
- C- -
2P2Q
1
ACSA_SALTY
A:
[90-625]
----------------------------------
G
D
R
T
A
I
I
W
E
G
D
D
T
-
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
D
-
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
A
D
E
G
-
V
R
--
A
G
R
SIP
L
K
K
N
V
D
D
A
L
K
NP
N
V
T
---------
S
--
V
---
E
----
H
V
I
--
V
L
K
R
T
-
G
S
D
-
I
-----------
D
W
Q
E
G
R
-
D
LW
W
R
D
L
I
E
K
A
-----
S
P
E
-
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
Y
L
V
Y
A
A
T
T
F
K
Y
V
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
WPT
P
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
I
--
E
G
T
D
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
KEK
C
P
V
V
D
T
W
W
Q
T
E
T
GGFMI
T
P
L
P
G
A
I
E
-----
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
A
T
E
G
N
L
V
I
T
---
D
---
S
W
---
P
G
Q
A
R
T
L
F
G
D
H
E
R
F
E
Q
T
Y
---
F
S
T
F
KNM
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
P
S
P
--
E
L
Y
A
E
V
R
N
W
V
E
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
-----------
9
PsiBlast_PDB
90.26
30%
0
- C- -
2P2B
2
ACSA_SALTY
A:
[90-627]
----------------------------------
G
D
R
T
A
I
I
W
E
G
D
D
T
-
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
D
-
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
A
D
E
G
-
V
R
--
A
G
R
S
I
P
L
K
K
N
V
D
D
A
L
K
NP
N
V
T
---------
S
--
V
---
E
----
H
V
I
--
V
L
K
R
T
-
G
S
D
-
I
-----------
D
W
Q
E
G
R
-
D
LW
W
R
D
L
I
E
K
A
-----
S
P
E
-
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
Y
L
V
Y
A
A
T
T
F
K
Y
V
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
WPT
P
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
I
--
E
G
T
D
R
S
S
L
R
I
L
G
S
A
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
KEK
C
P
V
V
D
T
W
W
Q
T
E
T
GGFM
I
T
P
L
P
G
A
I
E
-----
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
A
T
E
G
N
L
V
I
T
---
D
---
S
W
---
P
G
Q
A
R
T
L
F
G
D
H
E
R
F
E
Q
T
Y
---
F
S
T
F
KNM
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
P
S
P
--
E
L
Y
A
E
V
R
N
W
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
-----------
16
PsiBlast_PDB
88.74
29%
0
- C- -
1PG4
7
ACSA_SALTY
A:
[90-627]
----------------------------------
G
D
R
T
A
I
I
W
E
G
D
D
T
-
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
D
-
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
C
I
I
D
S
S
S
R
L
V
I
T
A
D
E
G
-
V
R
--
A
G
R
S
I
P
L
K
K
N
V
D
D
A
L
K
NP
N
V
T
---------
S
--
V
---
E
----
H
V
I
--
V
L
K
R
T
-
G
S
D
-
I
-----------
D
W
Q
E
G
R
-
D
LW
W
R
D
L
I
E
K
A
-----
S
P
E
-
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
Y
L
V
Y
A
A
T
T
F
K
Y
V
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
WPT
P
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
I
--
E
G
T
D
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
KEK
C
P
V
V
D
T
W
W
Q
T
E
T
GGFM
I
T
P
L
P
G
A
I
E
-----
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
A
T
E
G
N
L
V
I
T
---
D
---
S
W
---
P
G
Q
A
R
T
L
F
G
D
H
E
R
F
E
Q
T
Y
---
F
S
T
F
KNM
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
P
S
P
--
E
L
Y
A
E
V
R
N
W
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
-----------
15
PsiBlast_PDB
88.74
29%
0
- C- -
1PG3
5
ACSA_SALTY
A:
[90-626]
----------------------------------
G
D
R
T
A
I
I
W
E
G
D
D
T
-
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
D
-
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
C
I
I
D
S
S
S
R
L
V
I
T
A
D
E
G
-
V
R
--
A
G
R
S
I
P
L
K
K
N
V
D
D
A
L
K
NP
N
V
T
---------
S
--
V
---
E
----
H
V
I
--
V
L
K
R
T
-
G
S
D
-
I
-----------
D
W
Q
E
G
R
-
D
LW
W
R
D
L
I
E
K
A
-----
S
P
E
-
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
Y
L
V
Y
A
A
T
T
F
K
Y
V
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
WPT
P
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
I
--
E
G
T
D
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
KEK
C
P
V
V
D
T
W
W
Q
T
E
T
GGFM
I
T
P
L
P
G
A
I
E
-----
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
A
T
E
G
N
L
V
I
T
---
D
---
S
W
---
P
G
Q
A
R
T
L
F
G
D
H
E
R
F
E
Q
T
Y
---
F
S
T
F
KNM
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
P
S
P
--
E
L
Y
A
E
V
R
N
W
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
-----------
13
PsiBlast_PDB
88.74
29%
0
- C- -
2P2J
2
ACSA_SALTY
A:
[90-627]
----------------------------------
G
D
R
T
A
I
I
W
E
G
D
D
T
-
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
D
-
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
A
D
E
G
-
V
R
--
A
G
R
SIP
L
K
K
N
V
D
D
A
L
K
NP
N
V
T
---------
S
--
V
---
E
----
H
V
I
--
V
L
K
R
T
-
G
S
D
-
I
-----------
D
W
Q
E
G
R
-
D
LW
W
R
D
L
I
E
K
A
-----
S
P
E
-
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
Y
L
V
Y
A
A
T
T
F
K
Y
V
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
WPT
P
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
I
--
E
G
T
D
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
KEK
C
P
V
V
D
T
W
W
Q
T
E
T
GGFMI
T
P
L
P
G
A
I
E
-----
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
A
T
E
G
N
L
V
I
T
---
D
---
S
W
---
P
G
Q
A
R
T
L
F
G
D
H
E
R
F
E
Q
T
Y
---
F
S
T
F
KNM
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
P
S
P
--
E
L
Y
A
E
V
R
N
W
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
A
I
M
R
R
I
L
R
K
-----------
50
HHSearch
83.58
29%
0
- C- -
1PG4
7
ACSA_SALTY
A:
[87-632]
-----------------------------
Q
E
--
N
G
D
R
T
A
I
I
W
E
-
G
D
D
T
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
D
-
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
C
I
I
D
S
S
S
R
L
V
I
T
A
D
E
G
-
V
R
--
A
G
R
---------------
S
I
P
L
K
K
N
V
D
D
A
L
K
--
N
PNV
T
----
S
V
E
--
H
V
I
V
L
-
K
R
T
-
G
S
D
I
D
W
Q
E
GRDL
W
W
R
D
L
I
-
E
------
K
--
A
-----
S
P
E
-
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
Y
L
V
Y
A
A
T
T
F
K
Y
V
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
PNW
P
T
---
P
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
-
A
L
M
A
E
G
-
D
K
AI
E
G
T
D
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
GKE
K
---
C
P
V
V
D
T
W
W
Q
T
E
T
-----
G
G
F
M
I
T
P
L
P
G
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
A
T
E
G
N
L
V
I
T
---
D
---
S
W
---
P
G
Q
A
R
T
L
F
G
D
H
E
R
F
E
Q
T
Y
FST
F
K
N
M
---
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
P
S
P
--
E
L
Y
A
E
V
R
N
W
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
I
A
A
G
D
------
51
HHSearch
76.70
37%
-15
- C4 -
3ETC
11
?
A:
[66-559]
----------------------------
A
R
D
--
S
P
E
K
L
A
M
I
W
C
-
D
D
Y
-
G
N
E
K
I
F
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
K
-
H
G
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
I
A
E
D
-
D
V
P
E
Q
V
D
---------------
E
A
H
A
--------
E
--
C
---
G
----
D
I
P
L
K
K
A
K
V
G
G
D
V
L
-
E
-----------
G
W
I
D
F
R
-
K
------
E
L
E
E
SSPIF
E
R
P
-
T
G
----
E
V
S
T
K
N
E
D
I
C
L
V
Y
F
S
S
G
T
A
G
F
P
K
M
V
E
H
D
N
T
Y
P
L
G
H
I
-
L
T
A
K
Y
W
Q
N
V
E
D
D
G
L
H
Y
T
V
A
D
S
G
W
G
K
C
V
W
G
K
L
Y
G
Q
W
I
A
G
C
A
V
F
V
Y
-
D
Y
D
R
---
F
E
---
A
K
N
M
L
E
K
A
S
K
Y
G
V
T
T
F
C
A
P
P
T
I
Y
R
-
F
L
I
K
E
D
-
L
------
N
F
S
T
L
K
Y
A
V
V
A
G
E
P
L
N
P
E
V
F
N
R
F
L
E
F
T
---
G
---
I
K
L
M
E
G
F
G
Q
T
E
T
-----
V
V
T
I
A
T
F
P
W
M
--
E
P
K
P
G
S
I
G
K
P
T
P
G
Y
K
I
E
L
M
D
R
D
G
R
L
C
E
V
G
E
E
G
E
I
V
I
N
---
T
---
M
E
GKP
V
G
L
F
V
H
Y
G
K
D
P
E
R
T
E
E
T
W
---
H
D
G
Y
---
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
I
Q
H
P
A
V
L
E
C
A
I
T
G
V
P
D
P
V
R
G
Q
V
I
K
A
T
I
V
L
T
K
D
Y
T
P
S
D
--
S
L
K
N
E
L
Q
D
H
V
K
N
V
T
A
P
Y
K
Y
P
R
I
I
E
F
V
P
E
---------------------------
21
PsiBlast_CBE
76.54
36%
14
- C4 -
3ETC
10
?
B:
[49-562]
------
I
L
V
P
E
N
F
N
F
A
Y
D
-------
V
V
D
V
Y
A
R
D
S
P
E
K
L
A
M
I
W
C
-
D
D
Y
-
G
N
E
K
I
F
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
K
-
H
G
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
I
A
E
D
D
V
P
--
E
Q
V
---------------
D
E
A
---------
H
--
A
---
E
C
GDI
P
L
K
--
K
A
K
V
G
-
G
D
V
L
E
-----------
G
W
I
D
F
R
K
E
------
L
E
E
S
-----
S
P
I
-
F
E
RPTG
E
V
S
T
K
N
E
D
I
C
L
V
Y
F
S
S
G
T
A
G
F
P
K
M
V
E
H
D
N
T
Y
P
L
G
H
I
L
T
-
A
K
Y
W
Q
N
V
E
D
D
G
L
H
Y
T
V
A
D
S
G
W
G
K
C
V
W
G
K
L
Y
G
Q
W
I
A
G
C
A
V
F
V
Y
D
Y
-
D
R
---
F
E
---
A
K
N
M
L
E
K
A
S
K
Y
G
V
T
T
F
C
A
P
P
T
I
Y
R
-
F
L
I
K
-
E
-
D
L
--
S
H
Y
N
F
S
T
L
K
Y
A
V
V
A
G
E
P
L
N
P
E
V
F
N
R
F
L
E
F
T
---
G
---
I
K
L
M
E
G
F
G
Q
T
E
T
-----
V
V
T
I
A
T
F
P
W
M
--
E
P
K
P
G
S
I
G
K
P
T
P
G
Y
K
I
E
L
M
D
R
D
G
R
L
C
E
V
G
E
E
G
E
I
V
I
N
---
T
MEG
K
P
---
V
G
L
F
V
H
Y
G
K
D
P
E
R
T
E
E
T
W
---
H
D
G
Y
---
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
I
Q
H
P
A
V
L
E
C
A
I
T
G
V
P
D
P
V
R
G
Q
V
I
K
A
T
I
V
L
T
K
D
Y
T
P
S
D
--
S
L
K
N
E
L
Q
D
H
V
K
N
V
T
A
P
Y
K
Y
P
R
I
I
E
F
V
P
E
L
P
K
------------------------
25
PsiBlast_CBE
75.04
34%
23
- C4 -
3EQ6
2
ACS2A_HUMAN
B:
[34-562]
---------
P
A
K
F
N
F
A
S
D
VLDHWAD
M
E
K
A
G
K
--
R
P
P
S
P
A
L
W
W
V
-
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
-
I
Q
--
E
V
D
---------------
T
V
A
---------
S
EC
P
---
S
----
L
R
I
--
K
L
L
V
S
-
E
K
S
-
C
D----------
G
W
L
N
F
K
-
K
------
L
L
N
E
-----
A
S
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
L
G
L
K
A
K
M
D
A
G
-
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
---
F
D
---
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
-
D
L
--
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
--
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
VKP
I
---
R
P
---
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
---
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
H
D
PE
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
-------
23
PsiBlast_CBE
74.76
34%
23
- C4 -
2WD9
2
ACS2A_HUMAN
B:
[34-562]
---------
P
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
M
E
K
A
G
K
--
R
P
P
S
P
A
L
W
W
V
-
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
-
I
Q
--
E
V
D
---------------
T
V
A
---------
S
EC
P
---
S
----
L
R
I
--
K
L
L
V
S
-
E
K
S
-
C
D
----------
G
W
L
N
F
K
-
K
------
L
L
N
E
-----
A
S
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
L
G
L
K
A
K
M
D
A
G
-
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
---
F
D
---
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
-
D
L
--
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
--
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
VKP
I
---
R
P
---
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
---
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
-------
5
PsiBlast_PDB
74.66
34%
24
- C4 -
2VZE
1
ACS2A_HUMAN
A:
[34-562]
---------
P
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
M
E
K
A
G
K
--
R
P
P
S
P
A
L
W
W
V
-
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
-
I
Q
--
E
V
D
---------------
T
V
A
---------
S
EC
P
---
S
----
L
R
I
--
K
L
L
V
S
-
E
K
S
-
C
D
----------
G
W
L
N
F
K
-
K
------
L
L
N
E
-----
A
S
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
L
G
L
K
A
K
M
D
A
G
-
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
---
F
D
---
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
-
D
L
--
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
--
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
VKP
I
---
R
P
---
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
---
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
-------
6
PsiBlast_PDB
74.44
34%
26
- C4 -
3EQ6
2
ACS2A_HUMAN
A:
[34-562]
---------
P
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
M
E
K
A
G
K
--
R
P
P
S
P
A
L
W
W
V
-
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
-
I
Q
--
E
V
D
---------------
T
V
A
---------
S
EC
P
---
S
----
L
R
I
--
K
L
L
V
S
-
E
K
S
-
C
D
----------
G
W
L
N
F
K
-
K
------
L
L
N
E
-----
A
S
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
L
G
L
K
A
K
M
D
A
G
-
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
---
F
D
---
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
-
D
L
--
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
--
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
VKP
I
---
R
P
---
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
---
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
-------
1
PsiBlast_PDB
74.30
34%
24
- C4 -
2WD9
1
ACS2A_HUMAN
A:
[34-562]
---------
P
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
M
E
K
A
G
K
--
R
P
P
S
P
A
L
W
W
V
-
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
-
I
Q
--
E
V
D
---------------
T
V
A
---------
S
EC
P
---
S
----
L
R
I
--
K
L
L
V
S
-
E
K
S
-
C
D
----------
G
W
L
N
F
K
-
K
------
L
L
N
E
-----
A
S
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
L
G
L
K
A
K
M
D
A
G
-
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
---
F
D
---
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
-
D
L
--
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
--
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
VKP
I
---
R
P
---
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
---
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
-------
2
PsiBlast_PDB
74.28
34%
22
- C4 -
3B7W
6
ACS2A_HUMAN
A:
[34-562]
---------
P
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
M
E
K
A
G
K
--
R
P
P
S
P
A
L
W
W
V
-
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
-
I
Q
--
E
V
D
---------------
T
V
A
---------
S
EC
P
---
S
----
L
R
I
--
K
L
L
V
S
-
E
K
S
-
C
D
----------
G
W
L
N
F
K
-
K
------
L
L
N
E
-----
A
S
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
L
G
L
K
A
K
M
D
A
G
-
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
---
F
D
---
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
-
D
L
--
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
--
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
VKP
I
---
R
P
---
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
---
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
-------
27
PsiBlast_CBE
74.23
34%
23
- C4 -
2VZE
1
ACS2A_HUMAN
B:
[34-562]
---------
P
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
M
E
K
A
G
K
--
R
P
P
S
P
A
L
W
W
V
-
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
-
I
Q
--
E
V
D
---------------
T
V
A
---------
S
EC
P
---
S
----
L
R
I
--
K
L
L
V
S
-
E
K
S
-
C
D
----------
G
W
L
N
F
K
-
K
------
L
L
N
E
-----
A
S
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
L
G
L
K
A
K
M
D
A
G
-
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
---
F
D
---
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
-
D
L
--
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
--
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
VKP
I
---
R
P
---
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
---
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
-------
22
PsiBlast_CBE
74.16
34%
24
- C4 -
2WD9
2
ACS2A_HUMAN
C:
[34-562]
---------
P
A
K
F
N
F
A
S
D
VLDHWAD
M
E
K
A
G
K
--
R
P
P
S
P
A
L
W
W
V
-
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
-
I
Q
--
E
V
D
---------------
T
V
A
---------
S
EC
P
---
S
----
L
R
I
--
K
L
L
V
S
-
E
K
S
-
C
D----------
G
W
L
N
F
K
-
K
------
L
L
N
E
-----
A
S
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
L
G
L
K
A
K
M
D
A
G
-
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
---
F
D
---
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
-
D
L
--
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
--
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
VKP
I
---
R
P
---
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
---
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
H
D
PE
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
-------
3
PsiBlast_PDB
74.02
34%
24
- C4 -
3C5E
7
ACS2A_HUMAN
A:
[34-562]
---------
P
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
M
E
K
A
G
K
--
R
P
P
S
P
A
L
W
W
V
-
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
-
I
Q
--
E
V
D
---------------
T
V
A
---------
S
EC
P
---
S
----
L
R
I
--
K
L
L
V
S
-
E
K
S
-
C
D
----------
G
W
L
N
F
K
-
K
------
L
L
N
E
-----
A
S
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
L
G
L
K
A
K
M
D
A
G
-
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
---
F
D
---
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
-
D
L
--
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
--
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
VKP
I
---
R
P
---
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
---
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
-------
10
PsiBlast_PDB
73.67
30%
-7
- C4 -
2P2F
3
ACSA_SALTY
A:
[90-622]
----------------------------------
G
D
R
T
A
I
I
W
E
G
D
D
T
-
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
D
-
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
A
D
E
G
-
V
R
--
A
G
R
SIP
L
K
K
N
V
D
D
A
L
K
NP
N
V
T
---------
S
--
V
---
E
----
H
V
I
--
V
L
K
R
T
-
G
S
D
-
I
-----------
D
W
Q
E
G
R
-
D
LW
W
R
D
L
I
E
K
A
-----
S
P
E
-
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
Y
L
V
Y
A
A
T
T
F
K
Y
V
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
WPT
P
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
I
--
E
G
T
D
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
KEK
C
P
V
V
D
T
W
W
Q
T
E
T
GGFM
I
T
P
L
P
G
A
I
E
-----
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
A
T
E
G
N
L
V
I
T
---
D
---
S
W
---
P
G
Q
A
R
T
L
F
G
D
H
E
R
F
E
Q
T
Y
---
F
S
T
F
KNM
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
P
S
P
--
E
L
Y
A
E
V
R
N
W
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
-----------
26
PsiBlast_CBE
73.48
34%
23
- C4 -
2VZE
2
ACS2A_HUMAN
C:
[34-562]
---------
P
A
K
F
N
F
A
S
D
VLDHWAD
M
E
K
A
G
K
--
R
P
P
S
P
A
L
W
W
V
-
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
-
I
Q
--
E
V
D
---------------
T
V
A
---------
S
EC
P
---
S
----
L
R
I
--
K
L
L
V
S
-
E
K
S
-
C
D----------
G
W
L
N
F
K
-
K
------
L
L
N
E
-----
A
S
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
L
G
L
K
A
K
M
D
A
G
-
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
---
F
D
---
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
-
D
L
--
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
--
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
VKP
I
---
R
P
---
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
---
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
H
D
PE
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
-------
14
PsiBlast_PDB
73.47
29%
-8
- C4 -
2P2M
1
ACSA_SALTY
A:
[90-622]
----------------------------------
G
D
R
T
A
I
I
W
E
G
D
D
T
-
S
Q
S
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
D
-
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
R
I
I
D
S
S
S
R
L
V
I
T
A
D
E
G
-
V
R
--
A
G
A
SIP
L
K
K
N
V
D
D
A
L
K
NP
N
V
T
---------
S
--
V
---
E
----
H
V
I
--
V
L
K
R
T
-
G
S
D
-
I
-----------
D
W
Q
E
G
R
-
D
LW
W
R
D
L
I
E
K
A
-----
S
P
E
-
H
Q
----
P
E
A
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
Y
L
V
Y
A
A
T
T
F
K
Y
V
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
-
E
-
G
V
---
P
N
WPT
P
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
I
--
E
G
T
D
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
KEK
C
P
V
V
D
T
W
W
Q
T
E
T
GGFMI
T
P
L
P
G
A
I
E
-----
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
G
H
P
Q
E
G
A
T
E
G
N
L
V
I
T
---
D
---
S
W
---
P
G
Q
A
R
T
L
F
G
D
H
E
R
F
E
Q
T
Y
---
F
S
T
F
KNM
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
P
S
P
--
E
L
Y
A
E
V
R
N
W
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
-----------
4
PsiBlast_PDB
73.18
34%
25
- C4 -
3DAY
19
ACS2A_HUMAN
A:
[34-562]
---------
P
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
M
E
K
A
G
K
--
R
P
P
S
P
A
L
W
W
V
-
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
-
I
Q
--
E
V
D
---------------
T
V
A
---------
S
EC
P
---
S
----
L
R
I
--
K
L
L
V
S
-
E
K
S
-
C
D
----------
G
W
L
N
F
K
-
K
------
L
L
N
E
-----
A
S
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
L
G
L
K
A
K
M
D
A
G
-
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
---
F
D
---
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
-
D
L
--
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
--
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
VKP
I
---
R
P
---
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
---
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
--
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
-------
7
PsiBlast_PDB
73.12
34%
21
- C4 -
3GPC
2
ACS2A_HUMAN
A:
[34-562]
---------
P
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
M
E
K
A
G
K
--
R
P
P
S
P
A
L
W
W
V
-
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
-
I
Q
--
E
V
D
---------------
T
V
A
---------
S
EC
P
---
S
----
L
R
I
--
K
L
L
V
S
-
E
K
S
-
C
D
----------
G
W
L
N
F
K
-
K
------
L
L
N
E
-----
A
S
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
--
G
L
P
K
M
A
E
H
S
Y
S
S
L
G
L
K
A
K
M
D
A
G
-
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
---
F
D
---
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
-
D
L
--
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
---
L
D
I
R
E
S
Y
G
Q
T
E
T
-----
G
L
T
C
M
V
S
K
T
M
--
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
VKP
I
---
R
P
---
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
A
A
N
I
---
R
G
D
F
---
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
-------
24
PsiBlast_CBE
72.76
34%
20
- C4 -
3GPC
2
ACS2A_HUMAN
B:
[34-562]
---------
P
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
M
E
K
A
G
K
--
R
P
P
S
P
A
L
W
W
V
-
N
G
K
-
G
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
D
E
V
-
I
Q
--
E
V
D
---------------
T
V
A
---------
S
EC
P
---
S
----
L
R
I
--
K
L
L
V
S
-
E
K
S
-
C
D
----------
G
W
L
N
F
K
-
K
------
L
L
N
E
-----
A
S
T
T
H
H
----
C
V
E
T
G
S
Q
E
A
S
A
I
Y
F
T
S
---
G
L
P
K
M
A
E
H
S
Y
S
S
L
G
L
K
A
K
M
D
A
G
-
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
-
L
L
P
K
---
F
D
---
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
-
M
L
L
Q
-
Q
-
D
L
--
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
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-------