@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu29590: (2016-07-18 )
MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQLLQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVTESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEAAGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGTRLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLSEIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKVLLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR
Atome Classification :
(25 SA)
-.........10....-....20.--.......30...-.....40........50.......----.----60........70...-------------.....80---....-------..---..-.90--.........100.......110.......120.-......130.....---.--.140--........150.......160.....-.---------.-170--------........180.......190.......200.......210..--.-------....-------220..---.....230.......240.......250.......260.......270..-...-..280--..-.----..----..290.......300.--......310.......320..-....-.330.......340.......350.......360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-
M
I
YLDNSSTTK
P
Y
D
E
-
V
L
N
V
Y
E
Q
--
T
SSRYFG
N
P
S
S
L
-
H
RYGA
E
T
E
Q
L
L
Q
A
A
K
N
Q
I
K
R
S
LGL----
K
----
K
Y
D
I
V
F
TSGATEANN-------------AALKG
A
----
A
L
S
K-------IK---TG-
K
H
---
I
I
A
TSIEHP
S
V
T
E
S
L
E
Q
L
K
E
L
FGF
D
I
T
Y
L
S
VNE-DG
F
V
S
I
E
D
L
K
A
AIR---P--
D
T
V
---
L
V
S
M
M
HVNNEVGSVQ
P
I
E
A
A
G
E
V
L
K
E-H---------S-
N
I
---------
L
F
H
V
D
Y
VQ
G
I
Y
KVP
L
A
I
EKAGI
D
L
C
SISG
H
K
FHGLKG
T
G
A
L
I
V--K-------EG
T
R
-------
L
I
P
L
I---TGGSQQKGIRAGTEHT
A
G
A
V
S
L
A
K
A
INLASADFDTRL
D
T
M
T
A
V
K
E
L
F
M
N
R
-
L
S
E-IE
G
V
V
--
I
N-T----PQ----MNSAP
H
I
I
N
FSVPG
I
K
--
A
E
V
L
L
H
M
L
EEQ
D
I
F
V
STTSAC-SAKE-HKP
S
K
V
L
L
EMGKGEQIAG
S
S
I
R
I
S
L
NYSQ
T
S
D
V
A
E
P
F
M
N
A
L
R
P
G
I
K
K
L
R
E
M
MR-
4
PsiBlast_PDB
77.02
35%
-44
- C1 -
1EG5
3
?
A:
[3-373]
--
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
-
V
L
E
E
M
I
V
--
F
Y
R
E
K
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
----
S
----
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
-------------
W
I
L
K
T
V
----
A
E
T
F
-------
E
K
---
R
K
-
R
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
S
M
K
-
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
---
E
--
D
T
F
---
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
K
K
K
N
---------
K
-
E
T
---------
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
--
R
-------
K
G
V
P
-------
I
R
P
L
I
---
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
-
L
M
N
-
L
-
G
A
H
--
I
I
-
T
----
P
L
----
E
I
S
L
P
N
T
L
S
V
S
F
P
N
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
-------
K
K
I
E
E
I
L
--
3
PsiBlast_PDB
74.96
36%
-48
- C1 -
1ECX
2
?
A:
[3-369]
--
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
-
V
L
E
E
M
I
V
--
F
Y
R
E
K
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
----
S
----
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
-------------
W
I
L
K
T
V
----
A
E
T
F
-------
E
K
---
R
K
-
R
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
S
-
M
K
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
---
E
--
D
T
F
---
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
K
K
K
N
---------
K
-
E
T
---------
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
--
R
-------
K
G
V
P
-------
I
R
P
L
I
---
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
-
L
M
N
-
L
-
G
A
H
--
I
I
-
T
----
P
L
----
E
I
S
L
P
N
T
L
S
V
S
F
P
N
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
-------------
22
PsiBlast_CBE
74.33
36%
-47
- C1 -
1ECX
2
?
B:
[3-369]
--
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
-
V
L
E
E
M
I
V
--
F
Y
R
E
K
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
----
S
----
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
-------------
W
I
L
K
T
V
----
A
E
T
F
-------
E
K
---
R
K
-
R
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
S
-
M
K
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
---
E
--
D
T
F
---
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
K
K
K
N
---------
K
-
E
T
---------
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
--
R
-------
K
G
V
P
-------
I
R
P
L
I
---
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
-
L
M
N
-
L
-
G
A
H
--
I
I
-
T
----
P
L
----
E
I
S
L
P
N
T
L
S
V
S
F
P
N
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
-------------
R
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
-------------
2
PsiBlast_PDB
74.10
38%
26
- C1 -
3LVK
1
ISCS_ECO57
A:
[24-402]
--
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
-
V
A
E
K
M
M
Q
F
M
T
M
D
G
T
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
----
D
----
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
-------------
L
A
I
K
G
A
----
A
N
F
Y
-------
Q
K
---
K
G
-
K
H
---
I
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
E
G
F
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
---
D
--
D
T
I
---
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
R
A
-
R
---------
G
--
I
---------
I
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
R
K
-------
P
R
V
R
-------
I
E
A
Q
M
---
H
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
K
E
E
M
A
T
E
M
E
R
L
R
G
L
R
N
R
L
W
N
G
-
I
K
D
-
I
E
E
V
Y
--
L
N
-
G
----
D
L
----
E
H
G
A
P
N
I
L
N
V
S
F
N
Y
V
E
--
G
E
S
L
I
M
A
L
--
K
D
L
A
V
S
S
G
S
A
C
------
L
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
R
D
L
---
21
PsiBlast_CBE
73.92
38%
26
- C1 -
3LVJ
2
ISCS_ECO57
B:
[24-402]
--
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
-
V
A
E
K
M
M
Q
FM
T
M
D
G
T
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
----
D
----
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
-------------
L
A
I
K
G
A
----
A
N
F
Y
-------
Q
K
---
K
G
-
K
H
---
I
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
E
G
F
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
---
D
--
D
T
I
---
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
R
A
-
R
---------
G
--
I
---------
I
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
RR
K
-------
P
R
V
R
-------
I
E
A
Q
M
---
H
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
K
E
E
M
A
T
E
M
E
R
L
R
G
L
R
N
R
L
W
N
G
-
I
K
D
-
I
E
E
V
Y
--
L
N
-
G
----
D
L
----
E
H
G
A
P
N
I
L
N
V
S
F
N
Y
V
E
--
G
E
S
L
I
M
A
L
--
K
D
L
A
V
S
S
G
S
A
C
------
L
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
R
D
L
---
64
HHSearch
73.20
33%
9
- C1 -
4IXO
2
?
A:
[9-377]
-
M
I
Y
L
D
H
N
A
T
T
F
I
D
P
R
-
V
K
E
F
I
I
S
--
L
M
D
K
-
E
L
N
P
S
S
A
-
H
S
S
G
R
F
A
K
N
L
I
E
T
V
R
A
Q
I
A
T
A
L
G
I
----
T
LSSR
E
Y
D
I
T
F
T
S
S
G
T
E
G
N
N
-------------
L
I
M
K
N
F
----
Y
-
D
--------------
G
-
D
----
I
F
I
S
A
I
E
H
L
S
I
Y
N
H
I
N
Y
-----
A
P
N
I
K
V
I
S
V
N
T
-
Q
G
L
V
D
L
E
H
L
E
E
L
L
A
Q
SN
T
--
S
K
K
---
L
V
S
I
I
M
A
N
N
E
S
G
V
L
Q
D
I
A
E
I
G
K
I
T
K
K
-
Y
-----------
E
A
---------
K
F
H
S
D
L
V
Q
G
F
G
R
I
P
I
N
I
K
A
L
G
L
D
F
A
T
I
S
G
H
K
I
G
G
G
Q
G
G
A
A
L
I
S
--
S
-------
S
N
F
Q
-------
I
T
P
M
I
---
I
G
G
G
Q
E
K
S
V
R
S
G
T
E
N
V
L
A
I
A
G
F
G
L
A
S
A
L
R
T
D
N
I
S
E
N
Y
I
K
I
K
K
L
Q
E
N
L
E
K
K
-
L
K
K
-
Y
P
N
V
N
--
I
V
-
S
----
N
N
----
V
A
R
L
P
N
T
T
L
I
T
I
P
N
T
D
--
A
Q
A
K
L
I
G
F
D
L
H
N
I
C
V
S
S
G
------------
S
H
V
L
T
N
M
G
V
G
E
E
E
A
K
S
S
I
R
I
S
L
S
H
T
N
T
V
R
D
I
E
A
F
I
E
A
F
E
E
I
Y
D
V
-------
56
HHSearch
72.89
36%
12
- C1 -
1EG5
3
?
A:
[2-376]
-
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
-
V
L
E
E
M
I
V
--
F
Y
R
E
K
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
----
S
----
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
-------------
W
I
L
K
T
V
----
A
E
T
F
-------
E
K
----
R
K
R
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
S
M
-
K
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
---
E
--
D
T
F
---
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
K
K
-
K
---------
N
K
E
T
---------
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
--
R
-------
K
G
V
P
-------
I
R
P
L
I
---
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
-
L
M
N
-
L
-
G
A
H
--
I
I
-
T
----
P
L
----
E
I
S
L
P
N
T
L
S
V
S
F
P
N
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
--------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
1
PsiBlast_PDB
72.27
38%
27
- C1 -
3LVJ
2
ISCS_ECO57
A:
[24-402]
--
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
-
V
A
E
K
M
M
Q
F
M
T
M
D
G
T
F
G
N
P
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
----
D
----
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
-------------
L
A
I
K
G
A
----
A
N
F
Y
-------
Q
K
---
K
G
-
K
H
---
I
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
E
G
F
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
---
D
--
D
T
I
---
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
R
A
-
R
---------
G
--
I
---------
I
Y
H
V
D
A
T
Q
S
V
G
K
L
P
I
D
L
S
Q
L
K
V
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
R
K
-------
P
R
V
R
-------
I
E
A
Q
M
---
H
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
K
E
E
M
A
T
E
M
E
R
L
R
G
L
R
N
R
L
W
N
G
-
I
K
D
-
I
E
E
V
Y
--
L
N
-
G
----
D
L
----
E
H
G
A
P
N
I
L
N
V
S
F
N
Y
V
E
--
G
E
S
L
I
M
A
L
--
K
D
L
A
V
S
S
G
-------
S
-
L
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
G
R
F
T
T
E
E
E
I
D
Y
T
I
E
L
V
R
K
S
I
G
R
L
R
D
L
---
6
PsiBlast_PDB
71.57
32%
6
- C1 -
4EB5
6
ISCS2_ARCFU
A:
[2-376]
--
A
Y
F
D
Y
T
S
A
-
K
P
V
D
E
R
I
L
E
A
M
L
P
--
Y
M
T
E
S
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
----
G
----
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
-------------
L
A
I
I
G
Y
----
A
M
R
N
-------
A
R
---
K
G
-
K
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
Q
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
---
D
--
D
T
I
---
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
A
G
-
K
---------
A
-
A
L
-----------
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
--
R
-------
K
E
A
K
-------
L
Q
P
V
I
---
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
-
V
L
K
-
I
E
E
S
Y
--
L
N
-
G
----
H
P
----
E
K
R
L
P
N
N
V
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
K
T
-
L
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
---
68
HHSearch
71.27
31%
14
- C1 -
3A9Z
5
SCLY_RAT
A:
[19-430]
-
K
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
-
V
I
Q
A
V
T
E
--
A
M
K
E
A
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
----
K
----
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
-------------
L
V
I
H
S
T
----
V
R
C
F
H
E
Q
Q
T
L
Q-----
T
R
-
P
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
Q
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
---
P
--
T
T
C
---
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
-
L
N
Q
I
R
A
A
S
GL
P
-
R
V
---------
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
--
R
-------
G
V
G
K
-------
L
T
P
L
Y
P
ML
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
E
R
-
L
E
A
-
E
F
G
K
R
--
I
H
-
L
----
N
S
RFPG
V
E
R
L
P
N
T
C
N
F
S
I
Q
G
S
Q
LR
G
Y
M
V
L
A
Q
--
C
Q
T
L
L
A
S
V
G
A
S
C
-
H
S
D
H
E
D
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
E
G
----
7
PsiBlast_PDB
71.16
32%
4
- C1 -
4EB7
7
ISCS2_ARCFU
A:
[2-376]
--
A
Y
F
D
Y
T
S
A
-
K
P
V
D
E
R
I
L
E
A
M
L
P
--
Y
M
T
E
S
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
----
G
----
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
-------------
L
A
I
I
G
Y
----
A
M
R
N
-------
A
R
---
K
G
-
K
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
Q
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
---
D
--
D
T
I
---
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
A
G
-
K
---------
A
-
A
L
-----------
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
--
R
-------
K
E
A
K
-------
L
Q
P
V
I
---
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
-
V
L
K
-
I
E
E
S
Y
--
L
N
-
G
----
H
P
----
E
K
R
L
P
N
N
V
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
-
T
-
L
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
---
58
HHSearch
71.00
32%
0
* C1 *
4HVK
12
ISCS2_ARCFU
A:
[2-377]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
-
I
L
E
A
M
L
P
--
Y
M
T
E
S
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
----
G
----
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
-------------
L
A
I
I
G
Y
A
M
R
N
A
R
K
--------------
G
-
K
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
Q
K
-
Q
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
---
D
--
D
T
I
---
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
A
G
-------------
K
A
---------
A
L
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
--
R
-------
K
E
A
K
-------
L
Q
P
V
I
---
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
-
V
L
K
-
I
E
E
S
Y
--
L
N
-
G
----
H
P
----
E
K
R
L
P
N
N
V
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
----------
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
S
--
25
PsiBlast_CBE
70.92
34%
-10
- C1 -
3VAX
2
?
B:
[22-379]
--
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
-
V
A
D
I
V
L
H
--
W
M
T
A
E
F
G
N
A
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
----
E
----
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
-------------
I
A
L
L
G
L
----
A
P
Y
G
-------
E
R
---
T
G
R
R
H
---
I
I
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
A
G
R
-
G
F
E
V
D
F
L
T
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
---
P
--
D
T
L
---
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
R
A
-
T
---------
P
-
T
Y
---------
L
-
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
L
T
T
P
-
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
--
R
RREEMDD
E
R
V
P
-------
L
E
P
I
M
---
F
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
E
A
E
---
H
A
Q
W
Q
V
A
A
Q
D
L
R
S
R
L
-
L
A
G
-
L
A
S
T
S
FQ
V
N
-
G
----
D
Q
----
D
H
V
V
P
H
I
L
N
L
S
F
E
D
V
D
--
A
E
A
F
L
V
T
L
K
D
L
-
V
A
V
A
T
G
S
A
S
-
T
S
A
S
-
F
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
--------------------------
61
HHSearch
70.87
31%
6
- C1 -
4ISY
3
ISCSL_MYCTU
A:
[12-395]
-
S
A
Y
L
D
H
A
A
T
T
P
M
H
P
A
-
A
I
E
A
M
A
A
--
V
Q
R
T
-
I
G
N
A
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
----
R
----
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
-------------
L
A
V
K
G
I
----
Y
W
A
R
-------
R
D
A
EP
H
R
-
R
R
---
I
V
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
H
E
G
A
H
V
T
W
L
P
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
H
-
D
--
D
V
A
---
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
V
A
M
E
-
F
-----------
G
V
---------
P
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
--
R
-------
R
D
V
T
-------
C
V
P
L
M
---
H
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
V
D
G
L
E
E
N
S
A
R
L
R
L
L
R
D
R
L
V
E
G
-
V
L
A
E
I
D
D
V
C
--
L
N
-
G
----
A
D
D---
P
M
R
L
A
G
N
A
H
F
T
F
R
G
C
E
--
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
----------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
---
15
PsiBlast_PDB
70.65
31%
8
- C1 -
4IXO
2
?
A:
[9-371]
-
M
I
Y
L
D
H
N
A
T
T
F
I
D
P
R
-
V
K
E
F
I
I
S
--
L
M
D
K
E
L
-
N
P
S
S
A
-
H
S
S
G
R
F
A
K
N
L
I
E
T
V
R
A
Q
I
A
T
A
L
G
I
TLSS
R
----
E
Y
D
I
T
F
T
S
S
G
T
E
G
N
N
-------------
L
I
M
K
N
F
----
Y
----------------
D
-
G
D
---
I
F
I
S
A
I
E
H
L
S
I
Y
N
H
I
N
-----
Y
A
P
N
I
K
V
I
S
V
N
T
-
Q
G
L
V
D
L
E
H
L
E
E
L
L
A
---
Q
--
S
N
T
S
K
K
L
V
S
I
I
M
A
N
N
E
S
G
V
L
Q
D
I
A
E
I
G
K
I
T
K
K
-
Y
---------
E
--
A
---------
K
F
H
S
D
L
V
Q
G
F
G
R
I
P
I
N
I
K
A
L
G
L
D
F
A
T
I
S
G
H
K
I
G
G
G
Q
G
G
A
A
L
I
S
--
S
-------
S
N
F
Q
-------
I
T
P
M
I
---
I
G
G
G
Q
E
K
S
V
R
S
G
T
E
N
V
L
A
I
A
G
F
G
L
A
S
A
L
R
T
D
N
I
S
E
N
Y
I
K
I
K
K
L
Q
E
N
L
E
K
K
-
L
K
K
-
Y
P
N
V
N
--
I
V
-
S
----
N
N
----
V
A
R
L
P
N
T
T
L
I
T
I
P
N
T
D
--
A
Q
A
K
L
I
G
F
D
L
H
N
I
C
V
S
S
G
------------
S
H
V
L
T
N
M
G
V
G
E
E
E
A
K
S
S
I
R
I
S
L
S
H
T
N
T
V
R
D
I
E
A
F
I
E
A
F
-------------
9
PsiBlast_PDB
70.23
34%
-11
- C1 -
3VAX
1
?
A:
[22-379]
--
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
-
V
A
D
I
V
L
H
--
W
M
T
A
E
F
G
N
A
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
----
E
----
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
-------------
I
A
L
L
G
L
----
A
P
Y
G
-------
E
R
---
T
G
R
R
H
---
I
I
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
A
G
R
-
G
F
E
V
D
F
L
T
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
---
P
--
D
T
L
---
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
R
A
-
T
---------
P
-
T
Y
---------
L
-
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
L
T
T
P
-
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
--
R
R
R
EEMDD
E
R
V
P
-------
L
E
P
I
M
---
F
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
E
A
E
---
H
A
Q
W
Q
V
A
A
Q
D
L
R
S
R
L
-
L
A
G
-
L
A
S
T
S
F
Q
V
N
-
G
----
D
Q
----
D
H
V
V
P
H
I
L
N
L
S
F
E
D
V
D
--
A
E
A
F
L
V
T
L
K
D
L
-
V
A
V
A
T
G
S
A
S
-
T
S
A
S
-
F
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
--------------------------
5
PsiBlast_PDB
70.22
32%
9
- C1 -
4R5F
12
ISCS2_ARCFU
A:
[2-376]
--
A
Y
F
D
Y
T
S
A
-
K
P
V
D
E
R
I
L
E
A
M
L
P
--
Y
M
T
E
S
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
----
G
----
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
-------------
L
A
I
I
G
Y
----
A
M
R
N
-------
A
R
---
K
G
-
K
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
Q
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
---
D
--
D
T
I
---
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
A
G
-
K
---------
A
-
A
L
-----------
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
K
I
Y
G
P
K
G
V
G
A
L
W
I
--
R
-------
K
E
A
K
-------
L
Q
P
V
I
---
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
-
V
L
K
-
I
E
E
S
Y
--
L
N
-
G
----
H
P
----
E
K
R
L
P
N
N
V
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
----------
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
---
23
PsiBlast_CBE
70.15
32%
10
- C1 -
4EB7
4
ISCS2_ARCFU
B:
[2-376]
--
A
Y
F
D
Y
T
S
A
-
K
P
V
D
E
R
I
L
E
A
M
L
P
--
Y
M
T
E
S
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
----
G
----
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
-------------
L
A
I
I
G
Y
----
A
M
R
N
-------
A
R
---
K
G
-
K
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
Q
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
---
D
--
D
T
I
---
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
A
G
-
K
---------
A
-
A
L
-----------
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
--
R
-------
K
E
A
K
-------
L
Q
P
V
I
---
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
-
V
L
K
-
I
E
E
S
Y
--
L
N
-
G
----
H
P
----
E
K
R
L
P
N
N
V
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
K
T
-
L
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
---
47
Fugue
69.89
31%
6
- C1 -
4ISY
3
ISCSL_MYCTU
A:
[12-398]
-
S
A
Y
L
D
H
A
A
T
T
P
M
H
P
A
-
A
I
E
A
M
A
A
--
V
Q
-
R
T
I
G
N
A
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
----
R
----
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
-------------
L
A
V
K
G
I
----
Y
W
A
R
-------
R
D
---
A
E
-
P
H
RR
R
I
V
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
H
E
G
A
H
V
T
W
L
P
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
---
S
H
D
D
V
A
---
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
V
A
M
E
-
F
-----------
G
V
---------
P
M
H
S
D
A
I
Q
A
V
G
Q
L
P
L
D
F
G
A
S
G
L
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
--
R
-------
R
D
V
T
-------
C
V
P
L
M
---
H
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
V
D
G
L
E
E
N
S
A
R
L
R
L
L
R
D
R
L
V
E
G
V
L
A
E
-
I
D
D
V
C
--
L
N
G
A
----
D
D
----
P
M
R
L
A
G
N
A
H
F
T
F
R
G
C
E
--
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
----------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
L
A
46
Fugue
69.70
35%
30
- C1 -
1ECX
2
?
A:
[1-376]
M
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
-
V
L
E
E
M
I
V
--
F
Y
R
E
K
Y
G
N
P
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
----
S
----
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
-------------
W
I
L
K
T
V
----
A
E
T
F
-------
E
K
---
R
K
-
R
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
S
M
-
K
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
---
E
--
D
T
F
---
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
K
K
-
K
N--------
K
-
E
T
---------
L
V
H
V
D
A
V
Q
T
I
G
K
I
P
F
S
L
E
K
L
E
V
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
--
R
-------
K
G
V
P
-------
I
R
P
L
I
---
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
L
R
S
K
L
V
S
G
-
L
M
N
-
L
-
G
A
H
--
I
I
-
T
----
P
L
----
E
I
S
L
P
N
T
L
S
V
S
F
P
N
I
R
--
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
--------------
T
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
24
PsiBlast_CBE
69.64
32%
9
- C1 -
4EB5
5
ISCS2_ARCFU
B:
[2-376]
--
A
Y
F
D
Y
T
S
A
-
K
P
V
D
E
R
I
L
E
A
M
L
P
--
Y
M
T
E
S
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
----
G
----
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
-------------
L
A
I
I
G
Y
----
A
M
R
N
-------
A
R
---
K
G
-
K
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
Q
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
---
D
--
D
T
I
---
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
A
G
-
K
---------
A
-
A
L
-----------
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
--
R
-------
K
E
A
K
-------
L
Q
P
V
I
---
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
-
V
L
K
-
I
E
E
S
Y
--
L
N
-
G
----
H
P
----
E
K
R
L
P
N
N
V
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
K
T
-
L
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
---
8
PsiBlast_PDB
69.61
32%
8
- C1 -
4HVK
12
ISCS2_ARCFU
A:
[2-376]
--
A
Y
F
D
Y
T
S
A
-
K
P
V
D
E
R
I
L
E
A
M
L
P
--
Y
M
T
E
S
F
G
N
P
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
----
G
----
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
-------------
L
A
I
I
G
Y
----
A
M
R
N
-------
A
R
---
K
G
-
K
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
Q
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
---
D
--
D
T
I
---
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
A
G
-
K
---------
A
-
A
L
-----------
H
I
D
A
T
A
S
V
G
Q
I
E
V
D
V
E
K
I
G
A
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
--
R
-------
K
E
A
K
-------
L
Q
P
V
I
---
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
R
D
R
I
I
D
N
-
V
L
K
-
I
E
E
S
Y
--
L
N
-
G
----
H
P
----
E
K
R
L
P
N
N
V
N
V
R
F
S
Y
I
E
--
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
----------
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
---
62
HHSearch
69.55
34%
-6
- C1 -
3VAX
1
?
A:
[22-379]
--
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
-
V
A
D
I
V
L
H
--
W
M
T
A
E
F
G
N
A
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
----
E
----
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
-------------
I
A
L
L
G
L
----
A
P
Y
G
-------
E
R
---
T
G
R
R
H
---
I
I
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
A
G
-
R
G
F
E
V
D
F
L
T
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
---
P
--
D
T
L
---
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
R
A
-
T
-----------
P
T
---------
Y
L
H
V
D
A
A
Q
G
Y
G
K
V
P
G
D
L
T
T
-
P
I
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
--
R
-------
R
R
E
E
MDDERVP
L
E
P
I
M
---
F
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
E
A
E
H
A
Q
W
Q
V
A
A
Q
D
L
R
S
R
L
L
A
G
-
L
A
S
-
T
-
S
F
Q
--
V
N
-
G
----
D
Q
----
D
H
V
V
P
H
I
L
N
L
S
F
E
D
V
D
--
A
E
A
F
L
V
T
L
K
-
D
L
V
A
V
A
T
G
S
A
S
-
T
S
A
S
-
F
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G
--------------------------
12
PsiBlast_PDB
69.41
30%
3
- C1 -
3A9Z
5
SCLY_RAT
A:
[20-428]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
-
V
I
Q
A
V
T
E
--
A
M
K
E
A
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
----
K
----
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
F
H
E
Q
Q
T
L
Q
----------------------
T
R
-
P
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
Q
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
---
P
--
T
T
C
---
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
-
L
---------
N
-
Q
I
R
A
A
S
GL
P
R
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
--
R
GVG----
K
L
T
P
-------
L
Y
P
M
L
---
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
E
R
-
L
E
A
-
E
F
G
K
R
--
I
H
-
L
NSRF
P
G
----
V
E
R
L
P
N
T
C
N
F
S
I
Q
G
S
Q
--
L
R
G
Y
M
V
L
A
Q
C
Q
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
-
D
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
------
11
PsiBlast_PDB
67.31
30%
9
- C1 -
3A9X
3
SCLY_RAT
A:
[20-428]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
-
V
I
Q
A
V
T
E
--
A
M
K
E
A
W
G
N
P
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
----
K
----
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
F
H
E
Q
Q
T
L
Q
G
------------------EG-
T
R
-
P
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
Q
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
---
P
--
T
T
C
---
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
-
L
---------
N
-
Q
I
R
A
A
S
G
L
P
R
V
L
V
H
T
D
A
A
Q
A
L
G
K
R
R
V
D
V
E
D
L
G
V
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
--
R
GVG----
K
L
T
P
-------
L
Y
P
M
L
---
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
R
D
Y
L
E
E
R
-
L
E
A
-
E
F
G
K
R
--
I
H
-
L
NSRF
P
G
----
V
E
R
L
P
N
T
C
N
F
S
I
Q
G
S
Q
--
L
R
G
Y
M
V
L
A
Q
C
Q
T
L
L
A
S
V
G
A
--------------------
P
V
D
V
A
R
N
A
V
R
L
S
V
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
L
------