@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu29610: (2016-07-18 )
MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSIVEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKANQVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHLYGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKLLADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDIDEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETELVKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIEEVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLENAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFGNRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA
Atome Classification :
(20 SA)
----.........10........20..-......30........40........50.-.....---.--.60........70........80.------...-....90.......---.100........110..-.....-120.......130---------------------------------..--......140.......150....---...160.......170......-----.180...----...-.190.....------..200--........----210.......220......-------.-230........240.......250....--.....260.....-..270.......280....-...290..-.....300.......310-...--.....320.......330....------...340--....----.---------------...350-.......360.....--..370..-----.......380.-......390.......400..--.......410..------------.....420.......430.......440.......450.......460.......470....-..----------.480...--....490.......500..--.....510...----.--...520.......530.......540.......550.......560
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----M
E
F
V
I
G
L
L
I
V
L
L
A
L
F
A
A
G
Y
F
F
R
K
-
K
I
Y
A
E
I
D
R
L
E
S
W
K
I
E
I
L
N
R
S
I
V
E
E
M
S
K
I
K
-
H
LKMT---G--
Q
T
E
E
F
F
E
K
W
R
E
E
W
D
E
I
V
T
A
H
M
P
K
V
------
E
E
L
-
L
Y
DAEENA
D
K
Y
R
F---KKA-
N
Q
V
L
V
H
I
D
D
L
L
T
A
-
A
E
S
S
I
-
E
K
I
L
R
E
I
S
D
L
VT----------------------------------
S
E
--
E
K
S
R
E
E
I
E
Q
V
R
E
R
Y
S
K
S
R
K
N
L
L
A
---
Y
S
H
L
Y
G
E
L
Y
D
S
L
E
K
D
L
D
E
I
W
S
G
-----
I
K
Q
F
E
E
E----TEG-G
N
Y
I
T
A
R
K
V
------
L
L
EQ---DR
N
L
E
R
L
Q
----
S
Y
I
D
D
V
P
K
L
L
A
D
C
K
Q
TVPG-------
Q
-
I
A
-
K
L
K
D
G
Y
G
E
M
K
E
KG
Y
K
L
E
H
I
--
Q
L
D
K
--
E
L
E
N
L
S
N
Q
L
K
R
A
E
-
H
V
L
M
T
ELD
I
D
E
A
S
A
I
L
Q
L
I
-
D
E
N
I
Q
S
V
Y
-
Q
Q
LEG
E
V
E
A
G
Q
S
V
L
S
KM--
P
E
L
--
I
I
A
Y
D
K
L
K
E
E
K
E
H
T
K
A
E
T
E
L
V
K
------
E
S
Y
RL---
T
A
G
E----L---------------
G
K
Q
Q
A
F
-
E
K
R
L
D
E
I
G
K
L
L
S
S
V
K
--
D
KL--
D
A
-----
E
H
V
A
Y
S
L
L
V
E
E
-
V
A
S
I
E
K
Q
I
E
E
V
K
K
E
H
A
E
--
Y
R
--
E
N
L
Q
A
L
R
K
E
E
L
Q
------------
A
R
E
T
L
S
N
L
K
K
T
I
S
E
T
A
R
L
L
KTSNIPG
I
P
S
H
I
Q
E
M
L
E
N
A
H
H
H
I
Q
E
T
V
N
Q
L
N
ELPL
N
M
E
E
A
G
A
H
-
L
K
----------
Q
A
E
D
I
V
N
--RASR
E
S
E
E
L
V
E
Q
V
I
L
I
E
K
I
--
I
Q
F
G
N
R
FRSQN----
H
--
I
L
S
E
Q
L
K
E
A
E
R
R
F
Y
A
FDYDDS
Y
E
I
A
A
A
A
V
E
KAAPG
A
V
E
K
I
K
A
DISA
1
PsiBlast_PDB
66.80
99%
-51
- C7 -
4UXV
-
EZRA_BACSU
A:
[24-559]
----------------------------
K
I
Y
A
E
I
D
R
L
E
S
W
K
I
E
I
L
N
R
S
I
V
E
E
M
S
K
I
K
-
H
L
K
M
T
---
G
--
Q
T
E
E
F
F
E
K
W
R
E
E
W
D
E
I
V
T
A
H
M
P
K
V
------
E
E
L
-
L
Y
D
A
E
E
N
A
D
K
Y
R
F
---
K
K
A
-
N
Q
V
L
V
H
I
D
D
L
L
T
A
-
A
E
S
S
I
-
E
K
I
L
R
E
I
S
D
L
V
T
----------------------------------
S
E
--
E
K
S
R
E
E
I
E
Q
V
R
E
R
Y
S
K
S
R
K
N
L
L
A
---
Y
S
H
L
Y
G
E
L
Y
D
S
L
E
K
D
L
D
E
I
W
------------------------
Y
I
T
A
R
K
V
------
L
L
E
Q
---
D
R
N
L
E
R
L
Q
----
S
Y
I
D
D
V
P
K
L
L
A
D
C
K
Q
T
V
P
G
-------
Q
-
I
A
-
K
L
K
D
G
Y
G
E
M
K
E
K
G
Y
K
L
E
H
I
--
Q
L
D
K
--
E
L
E
N
L
S
N
Q
L
K
R
A
E
-
H
V
L
M
T
E
L
D
I
D
E
A
S
A
I
L
Q
L
I
-
D
E
N
I
Q
S
V
Y
-
Q
Q
L
E
G
E
V
E
A
G
Q
S
V
L
S
K
M
--
P
E
L
--
I
I
A
Y
D
K
L
K
E
E
K
E
H
T
K
A
E
T
E
L
V
K
------
E
S
Y
R
L
---
T
A
G
E
----
L
---------------
G
K
Q
Q
A
F
-
E
K
R
L
D
E
I
G
K
L
L
S
S
V
K
--
D
K
L
--
D
A
-----
E
H
V
A
Y
S
L
L
V
E
E
-
V
A
S
I
E
K
Q
I
E
E
V
K
K
E
H
A
E
--
Y
R
--
E
N
L
Q
A
L
R
K
E
E
L
Q
------------
A
R
E
T
L
S
N
L
K
K
T
I
S
E
T
A
R
L
L
K
T
S
N
I
P
G
I
P
S
H
I
Q
E
M
L
E
N
A
H
H
H
I
Q
E
T
V
N
Q
L
N
E
L
P
L
N
M
E
E
A
G
A
H
-
L
K
----------
Q
A
E
D
I
V
N
--
R
A
S
R
E
S
E
E
L
V
E
Q
V
I
L
I
E
K
I
--
I
Q
F
G
N
R
F
R
S
Q
N
----
H
--
I
L
S
E
Q
L
K
E
A
E
R
R
F
Y
A
F
D
Y
D
D
S
Y
E
I
A
A
A
A
V
E
K
A
A
P
G
A
V
E
K
I
K
A
D
---
13
HHSearch
65.29
99%
11
- C7 -
4UXV
-
EZRA_BACSU
A:
[24-559]
----------------------------
K
I
Y
A
E
I
D
R
L
E
S
W
K
I
E
I
L
N
R
S
I
V
E
E
M
S
K
I
K
-
H
L
K
M
T
---
G
--
Q
T
E
E
F
F
E
K
W
R
E
E
W
D
E
I
V
T
A
H
M
P
K
V
------
E
E
L
-
L
Y
D
A
E
E
N
A
D
K
Y
R
F
---
K
K
A
-
N
Q
V
L
V
H
I
D
D
L
L
T
A
-
A
E
S
S
I
-
E
K
I
L
R
E
I
S
D
L
V
T
----------------------------------
S
E
--
E
K
S
R
E
E
I
E
Q
V
R
E
R
Y
S
K
S
R
K
N
L
L
A
---
Y
S
H
L
Y
G
E
L
Y
D
S
L
E
K
D
L
D
E
I
W
------------------------
Y
I
T
A
R
K
V
------
L
L
E
Q
---
D
R
N
L
E
R
L
Q
----
S
Y
I
D
D
V
P
K
L
L
A
D
C
K
Q
T
V
P
G
-------
Q
-
I
A
-
K
L
K
D
G
Y
G
E
M
K
E
K
G
Y
K
L
E
H
I
--
Q
L
D
K
--
E
L
E
N
L
S
N
Q
L
K
R
A
E
H
V
-
L
M
T
E
L
D
I
D
E
A
S
A
I
L
Q
L
I
-
D
E
N
I
Q
S
V
Y
-
Q
Q
L
E
G
E
V
E
A
G
Q
S
V
L
S
K
M
--
P
E
L
--
I
I
A
Y
D
K
L
K
E
E
K
E
H
T
K
A
E
T
E
L
V
K
------
E
S
Y
R
L
---
T
A
G
E
----
L
---------------
G
K
Q
Q
A
F
-
E
K
R
L
D
E
I
G
K
L
L
S
S
V
K
--
D
K
L
--
D
A
-----
E
H
V
A
Y
S
L
L
V
E
E
-
V
A
S
I
E
K
Q
I
E
E
V
K
K
E
H
A
E
--
Y
R
--
E
N
L
Q
A
L
R
K
E
E
L
Q
------------
A
R
E
T
L
S
N
L
K
K
T
I
S
E
T
A
R
L
L
K
T
S
N
I
P
G
I
P
S
H
I
Q
E
M
L
E
N
A
H
H
H
I
Q
E
T
V
N
Q
L
N
E
L
P
L
N
M
E
E
A
G
A
H
-
L
K
----------
Q
A
E
D
I
V
N
--
R
A
S
R
E
S
E
E
L
V
E
Q
V
I
L
I
E
K
I
--
I
Q
F
G
N
R
F
R
S
Q
N
----
H
--
I
L
S
E
Q
L
K
E
A
E
R
R
F
Y
A
F
D
Y
D
D
S
Y
E
I
A
A
A
A
V
E
K
A
A
P
G
A
V
E
K
I
K
A
D
---
33
Fugue
35.07
20%
-77
* C7 *
4UY3
-
EZRA_STAA1
A:
[23-216]
------------------------
M
R
S
-
N
K
R
Q
I
I
E
K
A
I
E
R
K
N
E
I
E
T
L
P
F
D
Q
N
L
A
Q
L
S
-
K
L
N
L
K
---
G
--
E
T
K
T
K
Y
D
A
M
K
K
D
N
V
E
S
T
N
K
Y
L
A
P
V
------
E
E
K
-
I
H
N
A
E
A
L
L
D
K
F
S
F
---
N
A
S
-
Q
S
E
I
D
D
A
N
E
L
M
D
S
-
Y
E
Q
S
Y
-
Q
Q
Q
L
E
D
V
N
E
I
I
A
----------------------------------
L
Y
--
K
D
N
D
E
L
Y
D
K
C
K
V
D
Y
R
E
M
K
R
D
V
L
A
---
N
R
H
Q
F
G
E
A
A
S
L
L
E
T
E
I
E
K
F
E
P
R
-----
L
E
Q
Y
E
V
L
----
K
A
D
-
G
N
Y
V
Q
A
H
N
H
------
I
A
A
L
---
N
E
Q
M
K
Q
L
R
----
S
Y
M
H
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
35.07
20%
-77
- C7 -
4UY3
-
EZRA_STAA1
A:
[23-216]
------------------------
M
R
S
-
N
K
R
Q
I
I
E
K
A
I
E
R
K
N
E
I
E
T
L
P
F
D
Q
N
L
A
Q
L
S
-
K
L
N
L
K
---
G
--
E
T
K
T
K
Y
D
A
M
K
K
D
N
V
E
S
T
N
K
Y
L
A
P
V
------
E
E
K
-
I
H
N
A
E
A
L
L
D
K
F
S
F
---
N
A
S
-
Q
S
E
I
D
D
A
N
E
L
M
D
S
-
Y
E
Q
S
Y
-
Q
Q
Q
L
E
D
V
N
E
I
I
A
----------------------------------
L
Y
--
K
D
N
D
E
L
Y
D
K
C
K
V
D
Y
R
E
M
K
R
D
V
L
A
---
N
R
H
Q
F
G
E
A
A
S
L
L
E
T
E
I
E
K
F
E
P
R
-----
L
E
Q
Y
E
V
L
----
K
A
D
-
G
N
Y
V
Q
A
H
N
H
------
I
A
A
L
---
N
E
Q
M
K
Q
L
R
----
S
Y
M
H
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
34.89
20%
-65
- C7 -
4UY3
-
EZRA_STAA1
A:
[38-214]
----------------------------------------
K
N
E
I
E
T
L
P
F
D
Q
N
L
A
Q
L
S
-
K
L
N
L
K
---
G
--
E
T
K
T
K
Y
D
A
M
K
K
D
N
V
E
S
T
N
K
Y
L
A
P
V
------
E
E
K
-
I
H
N
A
E
A
L
L
D
K
F
S
F
---
N
A
S
-
Q
S
E
I
D
D
A
N
E
L
M
D
S
-
Y
E
Q
S
Y
-
Q
Q
Q
L
E
D
V
N
E
I
I
A
----------------------------------
L
Y
--
K
D
N
D
E
L
Y
D
K
C
K
V
D
Y
R
E
M
K
R
D
V
L
A
---
N
R
H
Q
F
G
E
A
A
S
L
L
E
T
E
I
E
K
F
E
P
R
-----
L
E
Q
Y
E
V
L
----
K
A
D
-
G
N
Y
V
Q
A
H
N
H
------
I
A
A
L
---
N
E
Q
M
K
Q
L
R
----
S
Y
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
31.90
17%
36
* C9 *
5DIY
1
?
B:
[2-473]
----
E
Y
F
R
Y
R
G
I
I
E
-------
G
F
Y
G
K
P
W
E
H
Q
E
R
L
D
M
F
E
F
M
Q
A
N
N
L
N
A
Y
I
Y
A
P
K
Q
D
L
Y
-
H
R
E
L
---------------
W
R
E
P
Y
K
---
E
E
Q
L
Q
L
F
------
K
E
L
-
I
E
K
A
G
S
C
G
I
N
F
T
F
---
A
I
S
-
P
G
L
S
L
V
Y
S
S
------
E
E
E
L
-
E
T
L
I
R
K
I
T
P
F
L
E
----------------------------------
M
G
--
V
H
S
I
G
I
F
F
D
N
V
P
F
D
L
I
H
E
E
D
R
N
S
---
Y
S
N
L
A
E
A
Q
A
D
F
L
T
R
V
L
Q
R
L
E
S
-----------------
T
I
S
-
T
P
Q
I
I
M
C
P
T
------
F
Y
C
N
---
D
P
N
L
E
Y
L
R
----
I
L
G
Q
R
L
P
K
N
I
-
D
V
F
W
T
G
P
N
-------
V
-
C
S
H
E
I
T
T
S
H
M
Q
E
V
Q
K
S
L
Q
R
P
A
T
--
L
W
D
N
--
Y
P
V
N
D
G
G
M
---------
M
P
E
L
H
I
G
P
Y
D
H
R
D
P
E
L
-
H
T
H
V
V
G
I
Y
-
A
N
P
M
A
L
P
E
A
S
K
L
P
L
Y
T
F
--
A
Q
Y
--
L
N
S
P
S
Q
Y
N
P
Q
D
S
W
R
Q
A
V
S
T
L
L
G
---------------------------------------------
E
D
N
L
S
A
M
E
K
F
Y
Q
S
-----------------
N
T
I
S
C
L
E
P
E
E
-
P
A
Y
L
T
N
L
F
K
K
V
Q
E
D
F
A
S
FR
F
E
--
Q
G
L
R
T
L
R
E
E
I
I
S
------------
M
Q
T
T
Y
S
R
L
S
T
Q
D
S
-----------------------
K
F
F
W
E
I
R
P
W
L
E
E
Y
K
L
W
T
D
Y
L
D
Q
A
M
I
T
-
F
S
----------
N
L
F
-------
A
R
E
S
L
Q
K
A
L
Q
G
R
T
Y
L
R
E
V
--
L
K
D
A
V
D
F
R
T
R
V
----
C
GD
V
V
R
N
F
L
Q
Q
V
L
R
S
T
V
S
I
E
L
Q
A
E
G
K
E
W
T
A
L
----
P
P
G
I
V
R
--------
23
HHSearch
29.34
14%
-478
- C7 -
2XS1
1
PDC6I_HUMAN
A:
[669-697]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
E
L
V
--
A
N
L
--
K
E
-----
G
T
K
F
Y
N
E
L
T
E
I
-
L
V
R
F
Q
N
K
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
29.32
34%
-440
- C7 -
2CH7
1
MCP2_THEMA
A:
[220-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
N
S
I
V
G
A
V
E
R
I
N
E
M
L
Q
N
I
A
A
A
I
E
E
Q
T
A
A
V
D
E
I
T
T
A
M
T
E
---
N
-
A
K
----------
N
A
E
E
I
T
N
---------------------------------------------------------------------------------------
30
HHSearch
28.64
10%
-100
- C3 -
3NA7
-
?
A:
[172-181]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
P
K
I
Y
S
F
Y
--------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
26.31
9%
-6
- C7 -
1HCI
-
ACTN2_HUMAN
A:
[272-746]
--------------
S
S
A
V
N
Q
E
N
E
R
L
M
E
-
E
Y
E
R
L
A
S
E
L
L
E
W
I
R
R
T
I
P
W
--
L
E
N
R
T
P
E
K
-
T
M
Q
A
M
---
Q
--
K
K
L
E
D
F
R
D
Y
R
R
K
H
K
P
P
K
V
Q
E
K
C
Q
L
------
E
I
N
-
F
N
T
L
Q
T
K
L
R
I
S
N
R
---
P
A
F
-
M
P
S
E
G
K
M
V
S
D
I
A
G
-
A
W
Q
R
L
-
E
Q
A
E
K
G
Y
E
E
W
L
L
----------------------------------
N
E
--
I
R
R
L
E
R
L
E
H
L
A
E
K
F
R
Q
K
A
S
T
H
E
T
---
W
A
-------
Y
G
K
E
Q
I
L
L
Q
--------------
K
D
----
Y
E
S
-
A
S
L
T
E
V
R
A
L
------
L
R
K
H
---
E
A
F
E
S
D
L
A
----
A
H
Q
D
R
V
E
Q
I
A
A
I
A
Q
E
L
N
E
L
------------------
D
Y
H
D
A
V
N
V
N
D
R
C
Q
--
K
I
C
D
--
Q
W
D
R
L
G
T
L
T
Q
K
R
R
-
E
A
L
E
R
M
E
K
L
L
E
T
---
I
D
Q
L
-
H
L
E
F
A
K
R
A
-
A
P
F
N
N
W
M
E
G
A
M
E
D
L
Q
D
----------------
M
F
I
V
H
S
I
E
E
I
Q
S
L
I
------
T
A
H
E
Q
---
F
K
A
T
----
L
---------------
P
E
A
D
G
E
-
R
Q
S
I
M
A
I
Q
N
E
V
E
K
V
I
--
Q
S
Y
--
N
I
-----
R
I
S
S
S
N
P
Y
S
T
V
T
M
D
E
L
R
T
K
W
D
K
V
K
Q
L
V
P
I
--
R
D
--
Q
S
L
Q
E
E
L
A
R
Q
H
A
------------
N
E
R
L
R
R
Q
F
A
A
Q
A
N
A
I
G
P
W
I
Q
N
K
M
E
E
I
A
R
S
S
------------
I
Q
I
T
G
A
L
E
D
Q
M
N
Q
L
K
Q
Y
E
H
N
-
I
I
----------
N
Y
K
N
N
I
D
--
K
L
E
G
D
H
Q
L
I
Q
E
A
L
V
F
D
N
K
H
--
T
N
Y
T
----------------
M
E
H
I
R
V
G
W
E
L
L
L
T
T
I
A
R
T
I
N
E
V
E
T
Q
I
L
T
R
D
--------------
34
Fugue
25.59
17%
67
- C8 -
5EK8
2
?
A:
[1-668]
M
S
T
K
T
K
T
I
F
D
E
I
K
A
A
L
V
L
K
V
I
D
S
P
L
G
R
-
K
L
I
E
E
K
A
E
K
Q
V
S
K
T
Q
E
A
I
T
K
P
I
E
Q
L
N
K
A
T
G
Q
L
L
F
S
---
D
--
T
N
K
P
L
H
N
I
E
L
E
V
W
D
R
D
V
G
T
P
S
D
Y
L
G
K
G
V
T
D
Q
N
G
-
R
F
E
I
Y
Y
D
P
E
K
A
G
F
---
K
D
A
P
D
L
E
L
R
V
I
D
N
R
V
T
F
-
D
S
D
N
Q
-
P
V
Y
T
N
R
I
A
Y
I
I
K
G
G
D
NVTQKTYDF
G
T
L
T
V
PYWPYDPNSPFARIFMP
N
P
--
E
E
T
P
D
D
Y
S
V
G
R
K
F
Q
A
Y
A
S
A
N
V
L
T
P
I
K
A
K
H
T
I
A
N
T
L
N
P
K
E
P
S
L
T
Q
I
Q
A
D
Y
PPN
L
T
I
N
L
D
R
E
KPGY
T
R
S
-
D
E
Y
F
V
L
R
V
L
NGMNPC
L
L
K
R
S
KS
D
P
N
Q
F
K
M
S
F
I
WD
N
Y
E
K
D
T
E
H
D
L
H
N
V
E
A
Y
F
V
L
K
DG
K
L
F
P
T
-
M
I
-
T
I
Q
S
R
Y
P
D
S
L
A
P
H
S
P
L
K
D
R
--
E
V
Y
T
--
P
--
N
D
G
E
K
W
L
Q
A
K
-
R
I
F
R
T
A
A
L
F
D
-
G
E
A
I
E
H
Y
A
-
K
A
H
V
Q
M
E
Q
-
Y
A
V
A
C
F
R
N
L
R
K
N
P
I
R
L
M
LT
P
H
L
KS
I
I
N
I
N
R
R
G
D
D
L
L
V
E
P
N
L
G
L
F
V
T
N
GPLT
Y
P
G
F
L
Q
---
M
C
T
E
----
V
V
A
T
YDWKD
W
Q
P
R
Q
P
I
C
D
D
H
K
Y
-
A
K
A
A
N
L
Y
W
Q
I
L
T
E
Y
V
--
D
A
F
--
F
A
-----
K
H
--
Q
Q
A
I
A
D
E
-
W
V
E
I
R
R
F
S
E
D
L
V
E
H
S
M
P
--
Y
Q
PI
E
G
I
M
A
N
T
D
S
D
Y
E
WYDTGELDKPDL
P
R
A
T
F
N
G
K
T
K
V
I
----
R
P
I
T
N
S
N
Q
P
S
-
A
T
D
I
D
N
L
K
Q
C
C
R
H
I
I
F
H
T
T
L
W
H
T
W
V
N
D
S
Q
S
D
E
G
G
E
-
L
A
YNSLALRNGS
F
G
S
E
T
D
P
--
N
I
A
P
D
P
I
E
A
T
N
Q
V
Y
I
F
S
V
L
N
G
I
K
Y
G
L
L
V
K
N
E
D
DDVP
E
--
E
L
R
T
A
L
L
N
R
K
D
Q
F
A
E
L
G
I
D
-----------------
I
G
N
I
R
T
L
I
N
I
37
Fugue
24.59
18%
88
* C8 *
1QOY
-
HLYE_ECOLI
A:
[-4-298]
----------------------------------------------------------------------------------------------------------------
S
M
A
E
---
I
V
A
-
D
K
T
V
E
V
V
K
N
A
I
E
T
-
A
D
G
A
L
-
D
L
Y
N
K
Y
L
D
Q
V
I
P
----------------------------------
W
Q
T
F
D
E
T
I
K
E
L
S
R
F
K
Q
E
Y
S
------
Q
A
---
A
S
V
L
V
G
D
I
K
T
L
L
M
D
S
Q
D
K
Y
F
E
A
-----
T
Q
T
V
Y
E
W
----
C
G
V
-
A
T
Q
L
L
A
A
Y
I
------
L
L
F
D
---
E
Y
N
E
K
K
A
S
----
A
Q
K
D
I
L
I
K
V
L
D
D
G
I
T
K
L
N
E
-------
A
-
Q
K
-
S
L
L
V
S
S
Q
S
F
N
N
A
S
G
K
L
L
A
L
D
S
Q
L
T
N
--
D
F
S
E
K
S
S
Y
F
Q
S
Q
V
-
D
K
I
R
K
E
A
Y
A
G
A
A
A
G
V
V
V
G
P
-
F
G
L
I
I
S
-
Y
-
S
I
A
A
G
V
V
E
G
-----
K
L
I
--
P
E
L
-----
K
N
K
L
K
S
V
Q
N
F
F
T
T
L
S
N
T
V
K
------
Q
A
N
K
D
---
I
D
A
A
----
K
---------------
L
K
L
T
T
E
-
I
A
A
I
G
E
I
K
T
E
T
E
T
T
R
--
F
Y
V
--
D
Y
-----
D
D
L
M
L
S
L
L
K
E
A
-
A
K
K
M
I
N
T
C
N
E
Y
Q
K
R
H
G
K
--
K
T
--
L
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
23.76
10%
23
- C8 -
4HPQ
-
?
C:
[2-411]
-------------------------
N
E
-
A
V
I
E
K
L
L
E
N
S
R
K
F
L
T
G
A
K
L
I
C
Q
E
S
N
D
H
L
T
-
T
T
K
L
R
---
I
--
R
E
W
Q
K
F
Q
S
K
L
H
F
V
L
D
C
I
Q
Q
Q
T
K
F
L
------
S
E
I
-
L
L
R
E
G
I
G
R
N
L
I
E
E
---
E
W
S
-
Q
T
V
L
V
R
L
V
N
D
M
K
F
-
W
Q
N
E
I
-
T
K
M
M
N
K
L
D
N
I
T
N
----------------------------------
E
I
--
D
Q
Q
H
N
S
--------------------------
K
L
G
D
F
I
S
R
D
----------------------------
S
S
H
I
L
D
S
K
------
L
N
E
I
---
P
T
I
R
K
Q
V
E
----
N
I
T
R
Q
Y
Q
T
M
L
A
K
V
Q
S
Q
L
V
E
S------
R
-
M
K
-
G
L
R
D
E
F
S
E
E
F
T
N
E
A
D
Q
L
E
Q
--
E
L
A
D
--
F
L
K
S
F
T
D
H
F
D
K
C
S
-
A
L
S
S
R
S
V
S
P
E
D
A
Q
N
L
F
E
I
V
-
E
R
D
D
K
D
L
A
-
A
I
N
S
L
L
Q
D
A
A
I
D
V
A
S
F
V
--
R
K
V
--
N
M
L
L
D
E
R
D
A
D
K
A
K
M
Q
A
T
L
S
K
L
L
------
T
E
L
R
K
---
H
E
E
Y
----
I
---------------
S
V
F
E
G
I
-
S
A
L
I
Q
K
F
K
A
S
C
L
E
D
I
--
R
Q
T
--
R
N
-----
L
L
D
F
Y
A
N
F
E
R
S
-
Y
H
N
L
L
K
E
V
K
R
R
K
E
T
A
A
K
--
L
S
--
Q
I
L
K
S
C
E
T
Q
L
E
Q
------------
I
N
T
A
D
L
R
E
R
Q
M
F
L
L
E
---------------------------------------------------------------------------------------------------
N
G
----
N
--
Y
L
P
E
T
I
W
P
D
E
I
G
S
L
S
P
L
Y
T
L
N
Y
E
V
R
---------------------
15
HHSearch
21.96
11%
95
- C7 -
4UXV
-
EZRA_BACSU
A:
[24-429]
--------------------------------
K
I
Y
A
E
I
D
R
L
--------
E
S
W
K
I
E
I
L
-
N
R
S
I
V
E
E
M
S
KI
K
H
L
K
M
T
G
Q
T
E
E
F
F
E
K
W
R
E
E
-
W
D
E
I
------
V
T
A
H
M
P
K
V
E
E
L
L
Y
D
A
E
E
---
N
A
D
-
K
Y
R
F
K
K
A
N
Q
V
L
V
H
-
I
D
D
L
L
-
T
A
A
E
S
S
I
E
K
I
L
R
----------------------------------
E
I
--
S
D
L
V
T
S
E
E
K
S
R
E
E
I
E
Q
V
R
E
R
Y
S
K
---
S
R
K
N
L
L
A
Y
S
H
L
Y
G
E
L
Y
D
S
L
E
K
D
-----
L
D
E
I
W
-------------------------
Y
I
T
A
---
R
K
V
L
L
E
Q
D
----
R
N
L
E
R
L
Q
S
Y
I
D
D
----
V
P
K
-------
L
-
L
A
-
D
C
K
---------------
Q
--
T
V
P
G
--
Q
I
A
K
L
K
D
G
Y
G
E
M
K
-
E
-
K
G
Y
K
L
E
H
I
Q
L
D
K
E
L
E
N
L
-
S
N
Q
L
K
R
A
E
H
V
L
M
T
E
L
---------
D
I
--
D
E
A
--
S
A
I
L
Q
L
I
D
E
N
I
Q
S
V
Y
Q
Q
L
E
G
E
V
------
E
A
G
Q
S
---
V
L
S
K
M
P
E
L
I
---------------
I
A
Y
D
K
L
-
K
E
E
K
E
H
T
K
A
E
T
E
L
V
K
--
E
S
Y
RL
T
A
G----
E
L
G
K
Q
Q
A
F
E
K
R
-
L
D
E
I
G
K
L
L
S
S
V
K
D
K
L
D
A
--
E
H
--
V
A
Y
S
L
L
V
E
E
V
A
S
------------
I
E
K
Q
I
E
E
V
K
K
E
H
A
E
Y
R
E
N
L
Q
A
L
R
---------
K
E
E
L
Q
A
R
E
T
L
S
N
L
K
K
T
I
S
E
T
---------------------------------------------------------------------------------------------------------------------
41
Fugue
21.85
21%
-41
- C7 -
2OQQ
-
HY5_ARATH
A:
[1-42]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
A
Y
-
L
S
E
L
E
N
R
V
K
D
L
E
N
K
N
S
E
--
L
E
--
E
R
L
S
T
L
Q
N
E
N
Q
M
------------
L
R
H
I
L
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
21.83
34%
-217
- C7 -
3JA6
-
MCP2_THEMA
G:
[440-488]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
N
S
I
V
G
A
V
E
R
I
N
E
M
L
Q
N
I
A
A
A
I
E
E
Q
T
A
A
V
D
E
I
T
T
A
M
T
E
---
N
-
A
K
----------
N
A
E
E
I
T
N
---------------------------------------------------------------------------------------
35
Fugue
21.43
9%
77
- C8 -
2NRJ
-
HBLA_BACCE
A:
[2-341]
-----------------------------------------------------------------------------------------------------
L
-
S
E
I
E
Q
T
N
N
G
D
T
A
L
SAN
E
A
R
M
K
E
T
L
Q
K
A
G
L
F
A
K
S
M
N
A
Y
S
Y
M
L
I
K
N
P
D
V
N
F
E
G
I
----------------------------------
T
I
--
N
G
Y
V
D
L
P
G
R
I
V
Q
D
Q
K
N
A
R
A
H
A
V
T
---
W
D
T
---
K
V
K
K
Q
L
L
D
T
L
N
G
I
V
E
Y
-----
D
T
T
F
D
N
Y
----
Y
E
T
M
V
E
A
I
N
T
G
D
-------
G
E
T
L
---
K
E
G
I
T
D
L
R
----
G
E
I
Q
Q
N
Q
K
Y
A
Q
Q
L
I
E
E
L
T
K
-------
L
-
R
D
-
S
I
G
H
D
V
R
A
F
G
S
N
K
E
L
L
Q
S
I
--
L
K
N
Q
GA
D
V
D
A
D
Q
K
R
L
E
E
V
L
-
G
S
V
N
Y
Y
K
Q
L
E
G
F
N
V
-----M
K
G
A
I
L
G
L
P
-
I
I
G
G
I
I
V
G
V
A
R
D
N
L
G
K
L
--
E
P
L
--
L
A
E
L
R
Q
T
V
D
Y
K
V
T
L
N
R
V
V
G
V
A
Y
------
S
N
I
N
E
M
H
K
A
L
D
D
----
A
---------------
I
N
A
L
T
Y
M
S
T
Q
W
H
D
L
D
S
Q
Y
S
G
V
L
--
G
H
I
--
E
N
A
A
Q
KA
D
Q
N
K
F
K
F
L
K
P
N
-
L
N
A
A
K
D
S
W
K
T
L
R
T
D
A
V
T
--
L
K
--
E
G
I
K
E
L
K
V
E
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
21.43
9%
-50
- C7 -
1VCS
-
VTI1A_MOUSE
A:
[1-100]
------------------------------------------------------------------
G
--
S
S
G
S
S
G
E
G
Y
E
Q
D
F
A
V
L
T
A
E
----
I
------
T
S
K
-
I
A
R
V
P
R
----
L
P
P
---
D
E
K
-
K
Q
M
V
A
N
V
E
K
Q
L
E
E
-
A
R
E
L
L
-
E
Q
M
D
L
E
V
R
E
I
P
P
----------------------------------
Q
S
R-
G
M
Y
S
N
R
M
R
S
Y
K
Q
E
M
G
K
L
E
T
D
F
K
R
---
S
R
I
A
S
G
P
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
21.00
11%
18
- C6 -
3U3I
-
?
A:
[1-479]
----
M
E
N
K
I
E
------
V
N
N
K
D
E
M
N
K
W
F
-
E
E
F
K
K
G
N
G
L
V
D
--
T
F
T
N
S
Y
S
F
C
E
S
V
P
N
L
D
-
R
F
V
F
Q
---
M
--
A
S
A
T
---------------------------------
D
D
A
Q
K
D
S
I
Y
A
---
S
A
L
-
V
E
A
T
K
F
C
A
P
I
Y
E
C
-
A
W
V
S
S
-
T
G
I
V
K
K
G
L
E
W
F
E
----------------------------------
K
-----
N
A
G
T
I
K
S
W
D
E
S
Y
T
E
L
K
V
E
V
P
K
---------------
I
E
Q
L
A
D
Y
Q
Q
A
-----
A
L
K
W
R
K
D
----
I
G
------------------
F
R
V
---
N
A
N
T
T
A
L
S
----
H
K
V
L
A
--------
E
Y
K
V
P
G
-------
E
I
V
M
-
S
V
K
E
M
L
S
D
M
I
R
R
R
N
L
I
L
R
E
--
H
V
E
W
--
C
R
E
F
V
K
G
K
Y
I
M
A
F
-
N
P
P
W
G
D
I
N
K
S
G
R
S
G
I
-
A
L
V
-
A
T
G
L
A
K
L
A
-
E
T
E
K
G
V
F
D
E
A
K
K
T
V
E
A
L
--
N
G
Y
--
L
N
K
-
H
K
D
E
V
D
K
A
S
A
D
S
M
I
T
N
L
L
------
K
H
I
A
K
---
A
Q
E
L
----
Y
---------------
K
N
S
S
A
L
-
R
A
Q
G
A
Q
I
D
T
A
F
S
S
Y
Y
W
L
Y
K
A
--
G
V
-----
T
P
E
T
F
P
T
V
S
Q
F
-
L
F
E
L
G
K
Q
----------------------
P
R
G
T
K
K
------------
M
K
K
A
L
L
S
T
P
L
K
W
G
K
K
L
Y
E
L
F
A
D
D
R
I
Y
M
H
P
A
V
L
T
-----
A
G
R
I
S
E
M
G
V
C
F
G
T
I
P
V
A
N
P
D
D
A
A
Q
G
S
G
----------
H
T
K
S
I
L
N
LR
T
N
T
E
T
N
N
P
C
A
K
T
I
V
K
L
F
E
I
--
Q
K
T
G
F
N
I
Q
D
M
D
----
I
--
V
A
S
E
H
L
L
H
Q
S
L
V
G
K
Q
S
P
F
Q
N
A
Y
N
V
K
G
N
A
T
S
A
---------------
19
HHSearch
20.73
10%
-123
- C7 -
4RH7
-
DYHC2_HUMAN
A:
[2282-2366]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
--
S
E
-----
L
K
E
K
F
Q
S
R
T
S
E
-
A
A
K
L
E
A
E
V
S
K
A
Q
E
T
I
K
A
--
A
E
--
V
L
I
N
Q
L
D
R
E
H
K
R
------------
W
N
A
Q
V
V
E
I
T
E
E
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------