@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu29680: (2016-07-18 )
MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNAAYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRVFIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERIPVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGSTGTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATNVIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGEPLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVDNQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYFWFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREGFEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGDLSTMED
Atome Classification :
(23 SA)
-----------------.........10........20........30.------------.......40........50...-----..--...60----....-...--.70.-.-......80........90........100.......110.......120.......130.......140.......150.-------------..-------....--160-.-------.----.--..-----...170........180--.----..----..-------...190..----.....200----.......210.......220.......230.....-.-..240.......250......---.260.......270......-.-280---.---.---....-..290.......300.......310.......320.......330.......340......---.350--........360.......370.-.......380.......390..------.....400......--.--410--.---.......420.....-.-..430.--.......440.......450.......460.......470.......480.......490.......500.......510-..--......520.......530.......540.......550...--....560.-......570----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------MNLKALPAIEGDHNL
K
N
Y
E
E
T
Y
R
HF
D
W
A
E
A
E
K------------HFSWHETGK
L
N
A
A
Y
E
A
I
D
R
H
A
E
-----
S
F
--RKN
K
V
----
A
L
Y
Y
-KDA--KRDE-K-
Y
T
F
K
E
M
K
E
ESN
R
A
G
N
V
L
R
RYGNVEKG
D
R
V
F
I
F
MPRSP
E
L
Y
F
I
M
LG
A
I
K
I
G
A
I
A
G
P
L
F
E
A
F
M
E
G
A
V
K
D
R
LENSE
A
K
V
V
VT
T
-------------
P
E
-------
L
L
E
R--IP--V-------D----K--LP-----H
L
Q
H
-
V
F
V
VGGEAESG---
T
----
N
I
----I
N
-------
Y
D
E
AAKQE----STRL
D
I
E
W
----MDKKD
G
F
L
L
H
YTSGSTGTP
K
G
V
L
H
V
H
E
A
-
M
I
Q
QYQ-T-G
K
W
V
L
D
LKEE
D
I
Y
W
CTADPG
W
---
V
T
G
T
V
Y
G
I
F
A
P
W
LNGAT
N
V
I
-V-G-G---R---F---
S
P
E
S
-
W
Y
G
T
I
E
QLG
V
N
V
W
YSA
P
T
A
F
R
M
L
MGAG
D
E
M
A
A
KY
D
L
T
S
L
R
H
V
L
SVGEPL
N
P
E
V
I
R
W
G
H
K
V
F
---
N
KR---IH
D
T
W
W
M
TETG
S
Q
L
I
CNYP-CM-DIKPGSMGKPIPGV
E
A
A
I
VDNQ------GNELPPYRMG
N
L
A
I--K--KG---
W
---
P
S
M
M
H
T
IW-N
N
P
E
K
Y
-
E
-SYFM-P--G
G
W
Y
VSGDSAYMDEE
G
Y
F
W
FQGRVD
D
V
I
MTSGERV
G
P
F
E
V
E
S
K
L
VEHPAIAEAGVIGKPDP
V
R
G
E
I
I
K
A
F
I
A
L
REGFE
P
--
S
D
--
K
L
K
E
E
I
R
L
F
V
K
Q
G
L
A
AHAAPR
E
I
E
FKDKLPKTRS
G
K
I
M
R
R
V
L
--
K
A
W
ELNLP-AGDLSTMED----
31
HHSearch
96.07
38%
0
- C- -
1PG4
7
ACSA_SALTY
A:
[67-632]
--------------------------------------------------------------
I
K
W
Y
E
D
G
T
L
N
L
A
A
N
C
L
D
R
H
L
Q
-----
E
---
N
G
D
R
T
----
A
I
I
W
-
E
G
D
DT
S
Q
S
K
-
H
-
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
D
-
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
C
I
I
D
S
S
S
R
L
V
I
T
A
-------------
D
E
-------
G
V
R
A
--
G
R
S
-
I
P
L
K
K
N
V
D
D
----
A
--
L
K
NPNVT
S
V
E
H
-
V
I
V
L
K
R
T
G
S
D
I
D
W
Q
E
G---
R
D
----
L
W
-------
W
R
D
L
I
E
K
A
----
S
P
E
H
Q
P
E
A
----
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
-
Y
L
V
Y
A
A
T
T
-
F
K
Y
V
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
---
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
-
F
-
E
-
G
---
V
PNW
P
---
T
P
A
R
-
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
I
E
G
T
D
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
GKE
K
C
P
---
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
-
G
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
------
G
H
P
Q
E
G
A
T
E
G
N
L
V
I
--
T
--
D
S
---
W
---
P
G
Q
A
R
T
L
F
-
G
D
H
E
R
F
-
E
Q
T
Y
F
S
T
F
--
K
N
M
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
P
--
S
P
--
E
L
Y
A
E
V
R
N
W
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
--
R
K
I
A
A
G
D
---------------
39
HHSearch
82.65
33%
-21
- C3 -
4WV3
1
?
A:
[14-519]
---------------------------------------------------------------------------
D
I
L
E
R
N
L
P
-----
V
---
R
A
N
K
T
----
A
L
F
T
-
P
D
------
R
-
E
-
M
T
F
R
Q
V
S
N
E
A
N
Q
V
G
N
A
L
K
G
-
L
G
V
R
F
G
E
C
V
G
L
L
T
L
D
S
A
E
W
V
T
S
F
F
G
I
V
K
L
G
A
I
A
V
G
I
N
T
L
L
K
P
P
E
Y
E
Y
I
L
R
D
C
R
A
R
V
L
I
V
H
-------------
Q
E
-------
F
L
P
L
--
I
E
--
S
I
R-----
G
----
N
--
L
P
-----
M
L
E
H
-
I
V
V
I
G
--------------
G
Y
----
L
S
-------
F
N
D
W
I
R
P
Q
----
P
T
T
L
E
A
A
Q
----
S
H
R
E
D
I
C
S
L
N
Y
S
S
G
-
T
G
G
P
K
G
I
P
H
A
H
K
D
-
Y
P
L
T
A
Q
L
W
-
G
V
N
V
L
G
L
R
E
S
D
R
T
F
A
L
A
K
L
F
F
---
T
F
G
T
G
G
N
L
I
F
P
W
Y
V
G
A
S
C
V
L
-
F
-
P
-
G
---
A
A--
R
---
V
A
S
N
-
V
L
S
T
I
S
R
F
K
P
T
I
F
Y
N
A
P
T
G
Y
A
A
A
L
A
L
K
D
--
F
S
Q
H
D
L
S
S
L
R
L
C
V
S
A
S
E
A
L
P
A
A
L
W
Y
A
W
K
E
A
T
---
G
V
D
---
I
I
D
G
I
G
C
T
E
N
F
H
I
F
I
S
N
R
P
--
G
-
D
I
R
P
G
S
S
G
K
P
V
E
G
Y
E
L
K
L
V
D
D
E
------
G
K
T
V
P
A
G
E
I
G
N
V
L
L
--
R
--
S
--------
E
T
A
A
L
S
Y
W
-
H
N
F
E
K
S
-
R
-
Q
T
F
--
Q
--
G
E
W
L
A
T
G
D
K
Y
F
V
D
A
D
G
Y
Y
W
H
A
G
R
S
D
D
M
L
K
V
G
G
I
W
V
S
P
V
E
V
E
S
T
L
I
Q
H
P
A
V
Q
E
C
A
V
I
G
C
P
D
Q
S
R
L
I
K
P
K
A
F
I
I
L
K
P
E
Q
I
P
--
S
E
--
A
L
I
R
Q
I
T
D
H
C
T
E
K
M
A
A
Y
K
R
P
R
W
I
E
F
V
T
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
--
R
S
A
A
K
L
A
---------------
21
PsiBlast_CBE
81.94
34%
-11
- C3 -
5IFI
3
?
C:
[110-643]
----------------------------------------------------------------
W
F
P
E
G
T
L
N
A
A
Y
N
C
L
D
R
H
Y
Y
-----
K
N
--
P
K
K
T
A
----
I
I
Y
E
-
A
D
E
--
P
S
E
S
-
R
E
V
S
Y
E
E
L
M
Q
E
T
C
R
V
A
N
V
L
K
S
Y
G
-
V
K
K
G
D
A
V
S
I
Y
L
P
M
T
W
Q
A
A
A
A
F
L
A
C
A
R
I
G
A
I
H
S
A
V
F
A
G
F
S
A
E
S
L
R
D
R
V
N
D
C
E
C
K
V
L
I
T
T
-------------
D
E
GRRGGKT
I
A
T
K
--
Q
I
--
V
-------
D
AALQ
Q
--
C
P
-----
L
V
E
N
-
V
L
V
L
---
R
R
T
G
---
N
----
K
V
----
P
M
TEGRDKW
W
D
E
E
C
A
K
M
----
P
A
Y
C
P
C
E
R
----
M
A
S
E
D
P
L
F
I
L
Y
T
S
----
K
P
K
G
V
V
H
S
T
A
G
Y
L
L
G
T
A
L
-
T
-
L
K
Y
V
F
D
A
H
P
D
D
R
F
A
C
M
A
D
I
G
W
---
I
T
G
H
S
Y
I
I
Y
G
P
L
A
N
G
I
T
T
A
V
-
F
-
E
-
S
---
T
---
P
VYP
T
P
S
R
-
Y
W
D
F
V
D
K
W
K
A
T
Q
L
Y
T
A
P
T
A
I
R
L
L
R
R
M
G
E
D
H
V
K
N
H
D
L
S
S
L
R
V
L
G
S
V
G
E
P
I
N
P
E
A
W
H
W
Y
N
D
F
A
---
G
K
N
QCA
I
V
D
T
Y
W
M
T
E
T
G
S
I
S
I
A
P
L
P
G
A
I
-
S
T
K
P
G
S
A
T
F
P
F
F
G
M
D
V
D
I
I
D
P
Q
TGQVLE
G
N
D
V
E
----
G
V
L
V
A
--
R
--
R
P
---
W
---
P
S
I
A
R
T
V
Y
-
R
D
H
K
R
Y
L
E
-
T
Y
M
K
-
P
Y-
P
G
Y
F
F
F
G
D
G
A
A
R
D
Y
D
G
Y
M
W
I
K
G
R
V
D
--
I
N
V
S
G
H
R
L
S
T
A
E
V
E
S
A
L
I
L
H
K
G
V
A
E
T
A
V
V
G
C
A
-------
V
Y
A
F
V
T
M
K
P
-----------
L
S
K
E
L
A
I
Q
V
R
K
V
I
G
P
F
A
A
P
K
K
I
Y
L
-----------------------------------------
3
PsiBlast_PDB
78.97
31%
11
- C3 -
3DAY
19
ACS2A_HUMAN
A:
[35-562]
--------------------------------------------------------------------
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
-----
M
E
--
K
A
G
K
R
PPSP
A
L
W
W
-
V
N
G
--
K
G
K
E
L
M
-
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
-------------
D
E
-------
V
I
Q
E
--
V
D
--
T
V
A-----
S
----
E
--
C
P
-----
S
L
R
I
-
K
L
L
V
S
E
K
S
C
D
G
---
W
----------
L
N
-------
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
V
E
----
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
-
M
-
D
A
G
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
---
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
---
F
---
D
P
L
V
-
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
---
Q
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
-
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
------
G
N
V
L
P
P
G
T
E
G
D
I
G
I
RV
K
--
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
-
A
-
A
N
I
R
----
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
--
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
--
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
------------------
55
Fugue
78.90
35%
31
- C3 -
1PG4
7
ACSA_SALTY
A:
[5-647]
HKHAIP
A
N
I
A
D
RCLIN
P
E
Q
Y
E
T
K
Y
K
Q
S
I
N
D
P
D
T
F
W
G
E
Q
G
K
I
L
D
W
I
T
P
Y
Q
K
V
K
N
T
S
FAPG
N
V
S
I
K
W
Y
E
D
G
T
L
N
L
A
A
N
C
L
D
R
H
L
Q
-----
E
N
--
G
D
R
T
A
----
I
I
W
E
G
D
D
T
--
S
Q
S
K
-
H
-
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
D
L
G
-
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
C
I
I
D
S
S
S
R
L
V
I
T
A
D
E
G
V
R
AG
R
S
I
P
L
K
K
N
-------
V
D
D
A
--
L
K
--
N
-------
P
----
N
--
V
T
-----
S
V
E
H
-
V
I
V
L
K
R
T
G
S
D
I
---
D
W
Q
E
G
R
D
----
L
W
-------
W
R
D
L
I
E
K
A
----
S
P
E
H
Q
P
E
A
----
M
N
A
E
D
P
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
Y
L
V
Y
A
A
T
-
T
-
F
K
Y
V
F
D
Y
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
---
V
T
G
H
S
Y
L
L
Y
G
P
L
A
C
G
A
T
T
L
M
-
F
-
E
-
G
VPN
W
---
P
---
T
P
A
R
-
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
D
K
A
I
E
G
T
D
R
S
S
L
R
I
L
G
S
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
---
G
K
E
K
C
P
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
P
L
P
G
A
I
-
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
P
A
L
V
D
N
E
------
G
H
P
Q
E
G
A
T
E
G
N
L
V
I
--
T
--
D
S
---
W
---
P
G
Q
A
R
T
L
F
-
G
D
H
E
R
F
-
E
-
Q
T
Y
F
-
S
TF
K
N
M
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
P
--
S
P
--
E
L
Y
A
E
V
R
N
W
V
R
K
E
I
G
P
L
A
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
--
R
K
I
A
A
G
D
A
D
P
G
V
V
E
K
L
L
E
E
K
Q
A
23
PsiBlast_CBE
78.55
31%
11
- C3 -
3EQ6
2
ACS2A_HUMAN
B:
[35-562]
--------------------------------------------------------------------
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
-----
M
E
--
K
A
G
K
R
PPSP
A
L
W
W
-
V
N
G
--
K
G
K
E
L
M
-
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
-------------
D
E
-------
V
I
Q
E
--
V
D
--
T
VA-----
S
----
E
--
C
P
-----
S
L
R
I
-
K
L
L
V
S
E
K
S
C
D
G
---
W
----------
L
N
-------
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
V
E
----
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
-
M
-
D
A
G
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
---
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
---
F
---
D
P
L
V
-
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
---
Q
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
-
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
------
G
N
V
L
P
P
G
T
E
G
D
I
G
I
RV
K
--
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
-
A
-
A
N
I
R
----
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
--
H
D
PE
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
RD
K
E
W
K
------------------
2
PsiBlast_PDB
78.26
31%
10
- C3 -
3C5E
7
ACS2A_HUMAN
A:
[35-562]
--------------------------------------------------------------------
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
-----
M
E
--
K
A
G
K
R
PPSP
A
L
W
W
-
V
N
G
--
K
G
K
E
L
M
-
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
-------------
D
E
-------
V
I
Q
E
--
V
D
--
T
V
A-----
S
----
E
--
C
P
-----
S
L
R
I
-
K
L
L
V
S
E
K
S
C
D
G
---
W
----------
L
N
-------
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
V
E
----
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
-
M
-
D
A
G
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
---
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
---
F
---
D
P
L
V
-
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
---
Q
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
-
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
------
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
V
K
--
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
-
A
-
A
N
I
R
----
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
--
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
------------------
25
PsiBlast_CBE
78.11
31%
11
- C3 -
2VZE
1
ACS2A_HUMAN
B:
[35-562]
--------------------------------------------------------------------
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
-----
M
E
--
K
A
G
K
R
PPSP
A
L
W
W
-
V
N
G
--
K
G
K
E
L
M
-
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
-------------
D
E
-------
V
I
Q
E
--
V
D
--
T
V
A-----
S
----
E
--
C
P
-----
S
L
R
I
-
K
L
L
V
S
E
K
S
C
D
G
---
W
----------
L
N
-------
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
V
E
----
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
-
M
-
D
A
G
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
---
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
---
F
---
D
P
L
V
-
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
---
Q
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
-
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
------
G
N
V
L
P
P
G
T
E
G
D
I
G
I
RV
K
--
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
-
A
-
A
N
I
R
----
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
--
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
------------------
5
PsiBlast_PDB
78.09
31%
10
- C3 -
3EQ6
2
ACS2A_HUMAN
A:
[35-562]
--------------------------------------------------------------------
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
-----
M
E
--
K
A
G
K
R
PPSP
A
L
W
W
-
V
N
G
--
K
G
K
E
L
M
-
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
-------------
D
E
-------
V
I
Q
E
--
V
D
--
T
V
A-----
S
----
E
--
C
P
-----
S
L
R
I
-
K
L
L
V
S
E
K
S
C
D
G
---
W
----------
L
N
-------
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
V
E
----
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
-
M
-
D
A
G
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
---
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
---
F
---
D
P
L
V
-
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
---
Q
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
-
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
------
G
N
V
L
P
P
G
T
E
G
D
I
G
I
RV
K
--
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
-
A
-
A
N
I
R
----
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
--
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
------------------
27
PsiBlast_CBE
77.92
31%
9
- C3 -
2WD9
2
ACS2A_HUMAN
B:
[35-562]
--------------------------------------------------------------------
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
-----
M
E
--
K
A
G
K
R
PPSP
A
L
W
W
-
V
N
G
--
K
G
K
E
L
M
-
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
-------------
D
E
-------
V
I
Q
E
--
V
D
--
T
V
A-----
S
----
E
--
C
P
-----
S
L
R
I
-
K
L
L
V
S
E
K
S
C
D
G
---
W
----------
L
N
-------
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
V
E
----
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
-
M
-
D
A
G
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
---
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
---
F
---
D
P
L
V
-
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
---
Q
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
-
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
------
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
V
K
--
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
-
A
-
A
N
I
R
----
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
--
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
------------------
7
PsiBlast_PDB
77.82
31%
11
- C3 -
2WD9
1
ACS2A_HUMAN
A:
[35-562]
--------------------------------------------------------------------
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
-----
M
E
--
K
A
G
K
R
PPSP
A
L
W
W
-
V
N
G
--
K
G
K
E
L
M
-
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
-------------
D
E
-------
V
I
Q
E
--
V
D
--
T
V
A-----
S
----
E
--
C
P
-----
S
L
R
I
-
K
L
L
V
S
E
K
S
C
D
G
---
W
----------
L
N
-------
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
V
E
----
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
-
M
-
D
A
G
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
---
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
---
F
---
D
P
L
V
-
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
---
Q
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
-
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
------
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
V
K
--
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
-
A
-
A
N
I
R
----
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
--
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
------------------
4
PsiBlast_PDB
77.63
31%
9
- C3 -
2VZE
1
ACS2A_HUMAN
A:
[35-562]
--------------------------------------------------------------------
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
-----
M
E
--
K
A
G
K
R
PPSP
A
L
W
W
-
V
N
G
--
K
G
K
E
L
M
-
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
-------------
D
E
-------
V
I
Q
E
--
V
D
--
T
V
A-----
S
----
E
--
C
P
-----
S
L
R
I
-
K
L
L
V
S
E
K
S
C
D
G
---
W
----------
L
N
-------
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
V
E
----
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
-
M
-
D
A
G
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
---
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
---
F
---
D
P
L
V
-
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
---
Q
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
-
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
------
G
N
V
L
P
P
G
T
E
G
D
I
G
I
R
V
K
--
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
-
A
-
A
N
I
R
----
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
--
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
------------------
26
PsiBlast_CBE
77.60
31%
12
- C3 -
2WD9
2
ACS2A_HUMAN
C:
[35-562]
--------------------------------------------------------------------
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
-----
M
E
--
K
A
G
K
R
PPSP
A
L
W
W
-
V
N
G
--
K
G
K
E
L
M
-
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
-------------
D
E
-------
V
I
Q
E
--
V
D
--
T
VA-----
S
----
E
--
C
P
-----
S
L
R
I
-
K
L
L
V
S
E
K
S
C
D
G
---
W
----------
L
N
-------
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
V
E
----
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
-
M
-
D
A
G
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
---
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
---
F
---
D
P
L
V
-
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
---
Q
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
-
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
------
G
N
V
L
P
P
G
T
E
G
D
I
G
I
RV
K
--
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
-
A
-
A
N
I
R
----
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
--
H
D
PE
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
RD
K
E
W
K
------------------
35
HHSearch
77.33
31%
14
- C3 -
3C5E
7
ACS2A_HUMAN
A:
[32-562]
-----------------------------------------------------------------
E
V
P
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
M
E
K
A
G
K
---
R
P
P
S
P
----
A
L
W
W
-
V
N
G
K-
G
K
E
L
-
M
-
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
-------------
D
E
-------
V
I
Q
E
--
V
D
--
T
V
A-----
S
----
E
--
C
P
-----
S
L
R
I
-
K
L
L
V
S
E
K
S
C
-----
D
----
G
W
----
L
N
-------
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
V
E
----
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
-
M
-
D
A
G
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
---
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
-
H
L
L
-
P
---
K
---
F
---
D
P
L
V
-
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
Q
Q
D
L
---
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
L
T
C
M
V
S
K
T
--
M
-
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
------
G
N
V
L
P
P
G
T
E
G
D
I
G
I
--
R
--
V
K
P
I
R
P
---
I
G
I
F
S
G
Y
V
-
D
N
P
D
K
T
-
A
-
A
N
I
--
R
--
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
HD
P
E
--
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
--
R
D
K
E
W
K
----------------
1
PsiBlast_PDB
77.12
31%
10
- C3 -
3B7W
6
ACS2A_HUMAN
A:
[35-562]
--------------------------------------------------------------------
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
-----
M
E
--
K
A
G
K
R
PPSP
A
L
W
W
-
V
N
G
--
K
G
K
E
L
M
-
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
-------------
D
E
-------
V
I
Q
E
--
V
D
--
T
V
A-----
S
----
E
--
C
P
-----
S
L
R
I
-
K
L
L
V
S
E
K
S
C
D
G
---
W
----------
L
N
-------
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
V
E
----
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
-
M
-
D
A
G
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
---
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
---
F
---
D
P
L
V
-
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
---
Q
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
-
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
------
G
N
V
L
P
P
G
T
E
G
D
I
G
I
RV
K
--
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
-
A
-
A
N
I
R
----
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
--
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
------------------
24
PsiBlast_CBE
77.02
31%
12
- C3 -
2VZE
2
ACS2A_HUMAN
C:
[35-562]
--------------------------------------------------------------------
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
-----
M
E
--
K
A
G
K
R
PPSP
A
L
W
W
-
V
N
G
--
K
G
K
E
L
M
-
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
-------------
D
E
-------
V
I
Q
E
--
V
D
--
T
VA-----
S
----
E
--
C
P
-----
S
L
R
I
-
K
L
L
V
S
E
K
S
C
D
G
---
W
----------
L
N
-------
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
V
E
----
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
-
M
-
D
A
G
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
---
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
---
F
---
D
P
L
V
-
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
---
Q
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
-
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
------
G
N
V
L
P
P
G
T
E
G
D
I
G
I
RV
K
--
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
-
A
-
A
N
I
R
----
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
--
H
D
PE
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
RD
K
E
W
K
------------------
29
PsiBlast_CBE
76.83
32%
10
- C3 -
4WV3
1
?
B:
[10-514]
--------------------------------------------------------------------------
Y
N
A
V
D
I
L
E
R
-----
N
L
PV
R
A
N
K
T
----
A
L
F
T
-
P
D
------
R
-
E
-
M
T
F
R
Q
V
S
N
E
A
N
Q
V
G
N
A
L
K
G
L
G
-
V
R
F
G
E
C
V
G
L
L
T
L
D
S
A
E
W
V
T
S
F
F
G
I
V
K
L
G
A
I
A
V
G
I
N
T
L
L
K
P
P
E
Y
E
Y
I
L
R
D
C
R
A
R
V
L
I
V
H
-------------
Q
E
-------
F
L
P
L
--
I
E
--
S
-------
I
----
R
GN
L
P
-----
M
L
E
H
-
I
V
V
I
G
E
G
P
Q
E
G
---------
Y
----
L
S
-------
F
N
D
W
I
R
P
Q
----
P
T
T
L
E
A
A
Q
----
S
H
R
E
D
I
C
S
L
N
Y
S
S
G
T
T
G
G
P
K
G
I
P
H
A
H
K
D
-
Y
P
L
T
A
Q
-
L
W
G
V
N
V
L
G
L
R
E
S
D
R
T
F
A
L
A
K
L
F
F
---
T
F
G
T
G
G
N
L
I
F
P
W
Y
V
G
A
S
C
V
L
-
F
-
P
-
G
---
A
---
A
---
R
V
A
S
N
V
L
S
T
I
S
R
F
K
P
T
I
F
Y
N
A
P
T
G
Y
A
A
A
L
A
L
K
D
--
F
S
Q
H
D
L
S
S
L
R
L
C
V
S
A
S
E
A
L
P
A
A
L
W
Y
A
W
K
E
A
T
---
G
V
D
---
I
I
D
G
I
G
C
T
E
N
F
H
I
F
I
S
N
R
P
--
G
-
D
I
R
P
G
S
S
G
K
P
V
E
G
Y
E
L
K
L
V
D
D
E
------
G
K
T
V
P
A
G
E
I
G
N
V
L
L
--
R
--
S
E
---
T
---
A
A
L
S
Y
--
W
-
H
N
F
E
K
S
-
R
-
Q
T
F
Q
----
G
E
W
L
A
T
G
D
K
Y
F
V
D
A
D
G
Y
Y
W
H
A
G
R
S
D
D
M
L
K
V
G
G
I
W
V
S
P
V
E
V
E
S
T
L
I
Q
H
P
A
V
Q
E
C
A
V
I
G
C
P
D
---
L
I
K
P
K
A
F
I
I
L
K
P
-
Q
I
P
--
S
E
--
A
L
I
R
Q
I
T
D
H
C
T
E
K
M
A
A
Y
K
R
P
R
W
I
E
F
V
T
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
--
R
S
--------------------
22
PsiBlast_CBE
76.67
31%
7
- C3 -
3GPC
2
ACS2A_HUMAN
B:
[35-562]
--------------------------------------------------------------------
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
-----
M
E
--
K
A
G
K
R
PPSP
A
L
W
W
-
V
N
G
--
K
G
K
E
L
M
-
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
-------------
D
E
-------
V
I
Q
E
--
V
D
--
T
V
A-----
S
----
E
--
C
P
-----
S
L
R
I
-
K
L
L
V
S
E
K
S
C
D
G
---
W
----------
L
N
-------
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
V
E
----
T
G
S
Q
E
A
S
A
I
Y
F
T
S
---
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
-
M
-
D
A
G
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
---
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
---
F
---
D
P
L
V
-
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
---
Q
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
-
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
------
G
N
V
L
P
P
G
T
E
G
D
I
G
I
RV
K
--
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
-
A
-
A
N
I
R
----
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
--
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
------------------
9
PsiBlast_PDB
76.62
32%
10
- C3 -
4WV3
1
?
A:
[10-514]
--------------------------------------------------------------------------
Y
N
A
V
D
I
L
E
R
-----
N
L
PV
R
A
N
K
T
----
A
L
F
T
-
P
D
------
R
-
E
-
M
T
F
R
Q
V
S
N
E
A
N
Q
V
G
N
A
L
K
G
L
G
-
V
R
F
G
E
C
V
G
L
L
T
L
D
S
A
E
W
V
T
S
F
F
G
I
V
K
L
G
A
I
A
V
G
I
N
T
L
L
K
P
P
E
Y
E
Y
I
L
R
D
C
R
A
R
V
L
I
V
H
-------------
Q
E
-------
F
L
P
L
--
I
E
--
S
-------
I
----
R
GN
L
P
-----
M
L
E
H
-
I
V
V
I
G
-----
G
---------
Y
----
L
S
-------
F
N
D
W
I
R
P
Q
----
P
T
T
L
E
A
A
Q
----
S
H
R
E
D
I
C
S
L
N
Y
S
S
G
-
T
G
G
P
K
G
I
P
H
A
H
K
D
-
Y
P
L
T
A
Q
-
L
W
G
V
N
V
L
G
L
R
E
S
D
R
T
F
A
L
A
K
L
F
F
---
T
F
G
T
G
G
N
L
I
F
P
W
Y
V
G
A
S
C
V
L
-
F
-
P
-
G
---
A
---
A
---
R
V
A
S
N
V
L
S
T
I
S
R
F
K
P
T
I
F
Y
N
A
P
T
G
Y
A
A
A
L
A
L
K
D
--
F
S
Q
H
D
L
S
S
L
R
L
C
V
S
A
S
E
A
L
P
A
A
L
W
Y
A
W
K
E
A
T
---
G
V
D
---
I
I
D
G
I
G
C
T
E
N
F
H
I
F
I
S
N
R
P
--
G
-
D
I
R
P
G
S
S
G
K
P
V
E
G
Y
E
L
K
L
V
D
D
E
------
G
K
T
V
P
A
G
E
I
G
N
V
L
L
--
R
--
S
E
---
T
---
A
A
L
S
Y
--
W
-
H
N
F
E
K
S
-
R
-
Q
T
F
Q
----
G
E
W
L
A
T
G
D
K
Y
F
V
D
A
D
G
Y
Y
W
H
A
G
R
S
D
D
M
L
K
V
G
G
I
W
V
S
P
V
E
V
E
S
T
L
I
Q
H
P
A
V
Q
E
C
A
V
I
G
C
P
D
Q
S
R
L
I
K
P
K
A
F
I
I
L
K
P
E
Q
I
P
--
S
E
--
A
L
I
R
Q
I
T
D
H
C
T
E
K
M
A
A
Y
K
R
P
R
W
I
E
F
V
T
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
--
R
S
--------------------
28
PsiBlast_CBE
75.36
32%
-8
- C3 -
3ETC
10
?
B:
[55-562]
----------------------------------------------------------------------
F
N
F
A
Y
D
V
V
D
V
Y
A
R
-----
D
S
--
P
E
K
L
A
----
M
I
W
C
-
D
D
Y
--
G
N
E
K
-
I
-
F
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
K
H
G
-
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
I
-------------
A
E
---------
D
D
--
V
P
E
Q
V
-------
D
----
E
---
A
-----
H
A
E
C
-
G
D
I
P
L
K
K
A
K
V
G
---
G
----
D
V
LEGW
I
D
-------
F
R
K
E
L
E
E
S
----
S
P
I
F
E
R
P
T
GEVS
T
K
N
E
D
I
C
L
V
Y
F
S
S
G
T
A
G
F
P
K
M
V
E
H
D
N
T
Y
-
P
L
G
H
I
L
-
T
-
A
K
Y
W
Q
N
V
E
D
D
G
L
H
Y
T
V
A
D
S
G
W
G
K
C
V
W
G
K
L
Y
G
---
Q
W
I
A
G
C
A
V
F
V
-
Y
-
D
Y
D
---
R
---
F
---
E
A
K
N
-
M
L
E
K
A
S
K
Y
G
V
T
T
F
C
A
P
P
T
I
Y
R
F
L
I
---
K
E
D
L
S
H
Y
N
F
S
T
L
K
Y
A
V
V
A
G
E
P
L
N
P
E
V
F
N
R
F
L
E
F
T
---
G
I
K
---
L
M
E
G
F
G
Q
T
E
T
-
V
V
T
I
A
T
F
P
-
W
M
-
E
P
K
P
G
S
I
G
K
P
T
P
G
Y
K
I
E
L
M
D
R
D
------
G
R
L
C
E
V
G
E
E
G
E
I
V
I
--
N
TM
E
G
---
K
---
P
V
G
L
F
V
H
Y
G
K
D
P
E
R
T
-
E
-
E
T
W
H
----
D
G
Y
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
I
Q
H
P
A
V
L
E
C
A
I
T
G
V
P
D
P
V
R
G
Q
V
I
K
A
T
I
V
L
T
K
D
Y
T
P
--
S
D
--
S
L
K
N
E
L
Q
D
H
V
K
N
V
T
A
P
Y
K
Y
P
R
I
I
E
F
V
P
E
L
P
K
-----------------------------------
8
PsiBlast_PDB
75.13
32%
-11
- C3 -
3ETC
11
?
A:
[55-559]
----------------------------------------------------------------------
F
N
F
A
Y
D
V
V
D
V
Y
A
R
-----
D
S
--
P
E
K
L
A
----
M
I
W
C
-
D
D
Y
--
G
N
E
K
-
I
-
F
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
K
H
G
-
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
I
-------------
A
E
---------
D
D
--
V
P
E
Q
V
-------
D
----
E
---
A
-----
H
A
E
C
-
G
D
I
P
L
K
K
A
K
V
G
---
G
----
D
V
LEGW
I
D
-------
F
R
K
E
L
E
E
S
----
S
P
I
F
E
R
P
T
GEVS
T
K
N
E
D
I
C
L
V
Y
F
S
S
G
T
A
G
F
P
K
M
V
E
H
D
N
T
Y
-
P
L
G
H
I
L
-
T
-
A
K
Y
W
Q
N
V
E
D
D
G
L
H
Y
T
V
A
D
S
G
W
G
K
C
V
W
G
K
L
Y
G
---
Q
W
I
A
G
C
A
V
F
V
-
Y
-
D
Y
D
---
R
---
F
---
E
A
K
N
-
M
L
E
K
A
S
K
Y
G
V
T
T
F
C
A
P
P
T
I
Y
R
F
L
I
---
K
E
D
L
---
N
F
S
T
L
K
Y
A
V
V
A
G
E
P
L
N
P
E
V
F
N
R
F
L
E
F
T
---
G
I
K
---
L
M
E
G
F
G
Q
T
E
T
-
V
V
T
I
A
T
F
P
-
W
M
-
E
P
K
P
G
S
I
G
K
P
T
P
G
Y
K
I
E
L
M
D
R
D
------
G
R
L
C
E
V
G
E
E
G
E
I
V
I
--
N
TM
E
G
---
K
---
P
V
G
L
F
V
H
Y
G
K
D
P
E
R
T
-
E
-
E
T
W
H
----
D
G
Y
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
I
Q
H
P
A
V
L
E
C
A
I
T
G
V
P
D
P
V
R
G
Q
V
I
K
A
T
I
V
L
T
K
D
Y
T
P
--
S
D
--
S
L
K
N
E
L
Q
D
H
V
K
N
V
T
A
P
Y
K
Y
P
R
I
I
E
F
V
P
E
--------------------------------------
6
PsiBlast_PDB
75.10
31%
11
- C3 -
3GPC
2
ACS2A_HUMAN
A:
[35-562]
--------------------------------------------------------------------
A
K
F
N
F
A
S
D
V
L
D
H
W
A
D
-----
M
E
--
K
A
G
K
R
PPSP
A
L
W
W
-
V
N
G
--
K
G
K
E
L
M
-
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
G
-------------
D
E
-------
V
I
Q
E
--
V
D
--
T
V
A-----
S
----
E
--
C
P
-----
S
L
R
I
-
K
L
L
V
S
E
K
S
C
D
G
---
W
----------
L
N
-------
F
K
K
L
L
N
E
A
----
S
T
T
H
H
C
V
E
----
T
G
S
Q
E
A
S
A
I
Y
F
T
S
G
--
G
L
P
K
M
A
E
H
S
Y
S
S
-
L
G
L
K
A
K
-
M
-
D
A
G
W
T
G
L
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
---
I
L
N
I
L
C
S
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L
-
L
-
P
---
K
---
F
---
D
P
L
V
-
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
---
Q
Q
D
L
S
S
Y
K
F
P
H
L
Q
N
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
---
I
R
E
S
Y
G
Q
T
E
T
G
--
L
T
C
M
V
S
K
T
M
-
K
I
K
P
G
Y
M
G
T
A
A
S
C
Y
D
V
Q
I
I
D
D
K
------
G
N
V
L
P
P
G
T
E
G
D
I
G
I
RV
K
--
P
I
---
R
---
P
I
G
I
F
S
G
Y
V
D
N
P
D
K
T
-
A
-
A
N
I
R
----
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
E
V
V
K
A
F
V
V
L
A
S
Q
F
L
S
--
H
D
P
E
Q
L
T
K
E
L
Q
Q
H
V
K
S
V
T
A
P
Y
K
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
------------------
34
HHSearch
72.69
31%
-5
- C3 -
3ETC
11
?
A:
[54-559]
---------------------------------------------------------------------
N
F
N
F
A
Y
D
V
V
D
V
Y
A
R
-----
D
---
S
P
E
K
L
----
A
M
I
W
-
C
D
D
Y-
G
N
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K
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Y
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A
A
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H
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-------------
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-------
D
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--
E
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-----
A
----
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--
C
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-----
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A
K
V
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--
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---
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----
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----
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-------
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SPIF
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----
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---
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---
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---
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------
N
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N
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---
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------
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N
--
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---
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----
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A
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E
--------------------------------------